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histological growth pattern

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https://www.readbyqxmd.com/read/28221183/the-effect-of-plasma-rich-in-growth-factors-on-pattern-hair-loss-a-pilot-study
#1
Eduardo Anitua, Ander Pino, Nahikari Martinez, Gorka Orive, Daniel Berridi
BACKGROUND: Autologous growth factors have proved to promote tissue regeneration in various medical fields. Recent findings suggest that platelet rich plasma may also play an important role in hair follicle restoration. OBJECTIVE: The objective of this study was to evaluate the safety and clinical efficacy of plasma rich in growth factors (PRGFs) for the treatment of androgenetic alopecia (AGA). MATERIALS AND METHODS: Five PRGF injections were administered over 19 patients with AGA...
February 17, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28208222/a-case-of-aggressive-solid-pseudopapillary-neoplasm-comparison-of-clinical-and-pathologic-features-with-non-aggressive-cases
#2
Yukihiro Watanabe, Kojun Okamoto, Katsuya Okada, Masayasu Aikawa, Isamu Koyama, Hiroshi Yamaguchi
Solid pseudopapillary neoplasms (SPNs) may have an aggressive clinical course, but clinical predictors of this condition have not been thoroughly evaluated. We performed a retrospective study of 11 cases of SPN managed in our hospital between January 2007 and April 2015. Of these 11 cases, we encountered a single case with an aggressive clinical course. Histological, immunohistochemical, and clinical features were compared to identify predictors of poor prognosis. The 11 patients comprised four women and seven men with a median age of 41 years (range, 26-58 years)...
February 16, 2017: Pathology International
https://www.readbyqxmd.com/read/28192747/biology-and-patterns-of-response-to-egfr-inhibition-in-squamous-cell-cancers-of-the-lung-and-head-neck
#3
REVIEW
Rosalyn A Juergens, Scott V Bratman, Ming-Sound Tsao, Scott A Laurie, M Sara Kuruvilla, Albiruni R A Razak, Aaron R Hansen
The identification of common molecular aberrations that drive cancer progression has led to targeted therapies that improve treatment efficacy in many tumor types. Epidermal growth factor receptor (EGFR) inhibitors have been used to treat both lung and head and neck cancers with squamous cell histology. These tumors often show high EGFR expression and/or increased gene copy number, but low incidence of the activating kinase domain mutations common to adenocarcinomas of the lung. In this manuscript, we review clinical trial data on EGFR-inhibitors in the treatment of squamous cell carcinoma (SqCC) of the lung and head and neck (SCCHN), including both efficacy and biomarker analyses...
January 17, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28190927/hepatocellular-adenoma-with-severe-fatty-change-in-a-male-spontaneously-diabetic-torii-rat
#4
Eriko Taniai-Riya, Katsuhiro Miyajima, Kochi Kakimoto, Takeshi Ohta, Yuzo Yasui, Yusuke Kemmochi, Akiko Anagawa-Nakamura, Kaoru Toyoda, Akemi Takahashi, Toshiyuki Shoda
The Spontaneously Diabetic Torii (SDT) rat is a rat model of nonobese type 2 diabetes mellitus, and hepatocellular adenomas have not been reported in this model. We report a hepatocellular adenoma with severe fatty change in a male 42-week-old SDT rat fed a high-fat diet. At necropsy, the animal had a whitish nodular mass of approximately 2 cm in diameter in the right medial lobe. Histologically, the mass was well demarcated from the surrounding tissues, slightly compressing the adjacent hepatic parenchyma and widely compartmented by fibrous connective tissues...
January 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28188750/kras-and-pik3ca-mutations-in-colorectal-adenocarcinomas-correlate-with-aggressive-histological-features-and-behavior
#5
Sejin Jang, Mineui Hong, Mi Kyung Shin, Byung Chun Kim, Hyung-Sik Shin, Eunsil Yu, Seung-Mo Hong, Jihun Kim, Sung Min Chun, Tae-Im Kim, Kyung-Chan Choi, Young Woong Ko, Jeong Won Kim
Tumor budding (TB) in colorectal carcinoma (CRC) is related to epithelial-mesenchymal transition (EMT) and has been recently characterized as an indicator of poor prognosis along with lymphovascular tumor emboli (LVE), perineural invasion (PNI), and an infiltrative growth pattern. Mutations in the genes of the Ras-MAPK and PI3K pathways are associated with EMT and an aggressive CRC phenotype and have been used in patient stratification for anti-EGF receptor therapies; however, the impact of these mutations on CRC morphology and behavior remains unclear...
February 8, 2017: Human Pathology
https://www.readbyqxmd.com/read/28183840/imaging-characteristics-of-pediatric-diffuse-midline-gliomas-with-histone-h3-k27m-mutation
#6
M S Aboian, D A Solomon, E Felton, M C Mabray, J E Villanueva-Meyer, S Mueller, S Cha
BACKGROUND AND PURPOSE: The 2016 World Health Organization Classification of Tumors of the Central Nervous System includes "diffuse midline glioma with histone H3 K27M mutation" as a new diagnostic entity. We describe the MR imaging characteristics of this new tumor entity in pediatric patients. MATERIALS AND METHODS: We retrospectively reviewed imaging features of pediatric patients with midline gliomas with or without the histone H3 K27 mutation. We evaluated the imaging features of these tumors on the basis of location, enhancement pattern, and necrosis...
February 9, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28159752/studies-of-an-androgen-binding-protein-knockout-corroborate-a-role-for-salivary-abp-in-mouse-communication
#7
Amanda G Chung, Phillip M Belone, Barbora Vošlajerová Bímová, Robert M Karn, Christina M Laukaitis
The house mouse Androgen-binding protein (Abp) gene family is comprised of 64 paralogs, 30 Abpa and 34 Abpbg, encoding the alpha (ABPA) and betagamma (ABPBG) protein subunits that are disulfide-bridged to form dimers in secretions. Only 14 Abp genes are expressed in distinct patterns in the lacrimal (11) and submandibular glands (3). We created a knockout mouse line lacking two of the three genes expressed in submandibular glands, Abpa27 and Abpbg27, by replacing them with the neomycin resistance gene. The knockout genotype (-/-) showed no Abpa27 or Abpbg27 transcripts in submandibular gland cDNA libraries and there was a concomitant lack of protein expression of ABPA27 and ABPBG27 in the -/- genotype saliva, shown by elimination of these two proteins from the saliva proteome and the loss of cross-reactive material in the acinar cells of the submandibular glands...
February 3, 2017: Genetics
https://www.readbyqxmd.com/read/28145465/molecular-morphological-and-survival-analysis-of-177-resected-pancreatic-ductal-adenocarcinomas-pdacs-identification-of-prognostic-subtypes
#8
Anna Melissa Schlitter, Angela Segler, Katja Steiger, Christoph W Michalski, Carsten Jäger, Björn Konukiewitz, Nicole Pfarr, Volker Endris, Markus Bettstetter, Bo Kong, Ivonne Regel, Jörg Kleeff, Günter Klöppel, Irene Esposito
Pancreatic ductal adenocarcinoma (PDAC) has generally a poor prognosis, but recent data suggest that there are molecular subtypes differing in clinical outcome. This study examines the association between histopathologic heterogeneity, genetic profile, and survival. Tumor histology from 177 resected PDAC patients with follow-up data was subclassified according to predominant growth pattern, and four key genes were analyzed. PDACs were classified as conventional (51%), combined with a predominant component (41%), variants and special carcinomas (8%)...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28144985/socs3-immunohistochemical-expression-seems-to-support-the-2005-and-2014-international-society-of-urological-pathology-isup-modified-gleason-grading-system
#9
Francesco Pierconti, Maurizio Martini, Tonia Cenci, Gian Luigi Petrone, Riccardo Ricci, Emilio Sacco, Pier Francesco Bassi, Luigi Maria Larocca
BACKGROUND: In the 2014, The International Society of Urological Pathology (ISUP) consensus conference update the grading of prostate, last revised in 2005. In this study we evaluate the SOCS3 immunohistochemical protein expression in different Gleason prostatic adenocarcinoma: classical Gleason grade 3, classical Gleason grade 3 upgraded to Gleason grade 4 according to the ISUP modifications and classical and modified Gleason grade 4. The major conclusions were: (i) Cribriform glands should be assigned a Gleason pattern 4, regardless of morphology; (ii) Glomeruloid glands should be assigned a Gleason pattern 4, regardless of morphology; (iii) Grading of mucinous carcinoma of the prostate should be based on its underlying growth pattern rather than all as pattern 4; and (iv) Intraductal carcinoma of the prostate without invasive carcinoma should not assigned Gleason grade and a comment about aggressive carcinoma probably associated should be made...
February 1, 2017: Prostate
https://www.readbyqxmd.com/read/28126352/preclinical-evaluation-of-luffa-operculata-cogn-and-its-main-active-principle-in-the-treatment-of-bacterial-rhinosinusitis
#10
Leonardo Silva, Henrique Olival Costa, Flávia Coelho de Souza, Elaine Monteiro Cardoso Lopes, Suely Mitoi Ykko Ueda
INTRODUCTION: The prevalence of rhinosinusitis is quite high. Despite the widespread use of antibiotics for rhinosinusitis, there are other forms of treatment, including phytotherapy. One of the most widely used herbal medicines for treatment of rhinosinusitis is Luffa operculata. OBJECTIVE: This study aimed to evaluate the efficacy of topical nasal solution of the aqueous extract of L. operculata, determining the toxicity to its use and identifying the active principles presented in the aqueous extract...
December 26, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28123467/correlation-between-microvascular-characteristics-and-the-expression-of-mvd-igf-1-and-stat3-in-the-development-of-colonic-polyps-carcinogenesis
#11
Hong Liu, Jing Wu, Xiang-Chun Liu, Nan Wei, Kui-Liang Liu, Yan-Hui Ma, Hong Chang, Quan Zhou
The aim of the present study was to investigate the correlation between vascular characteristics under narrow band imaging (NBI) and the expression of angiogenic factors of colorectal carcinoma and adenoma, and to evaluate the feasibility of NBI in vivo visualizing angiogenesis. Patients with colorectal polyps, which were pathologically confirmed as early carcinoma and adenoma, were recruited and examined by NBI. The vascular pattern was classified into type I (invisible or faintly visible vasculature), type II (clearly visible microvasculature that is regularly arranged in a round, oval honeycomb-like pattern) and type III (clearly visible microvasculature that is irregularly arranged in size and caliber or has irregular winding)...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28114909/low-glycemic-index-diet-exercise-and-vitamin-d-to-reduce-breast-cancer-recurrence-dedica-design-of-a-clinical-trial
#12
Livia S A Augustin, Massimo Libra, Anna Crispo, Maria Grimaldi, Michele De Laurentiis, Massimo Rinaldo, Massimiliano D'Aiuto, Francesca Catalano, Giuseppe Banna, Francesco Ferrau', Rosalba Rossello, Diego Serraino, Ettore Bidoli, Samuele Massarut, Guglielmo Thomas, Davide Gatti, Ernesta Cavalcanti, Monica Pinto, Gabriele Riccardi, Edward Vidgen, Cyril W C Kendall, David J A Jenkins, Gennaro Ciliberto, Maurizio Montella
BACKGROUND: Mechanisms influencing breast cancer (BC) development and recurrence include hyperglycemia, hyperinsulinemia, high insulin-like growth factor-1, high circulating estrogen, inflammation and impaired cellular differentiation/apoptosis. A lifestyle program that targets all the above mechanisms may be warranted. Low glycemic index (GI) foods produce lower post-prandial glucose and insulin responses and have been associated with lower BC risk. Moderate physical activity post-diagnosis reduces BC recurrence and mortality, partly explained by reduced insulin and estrogen levels...
January 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28107191/epidermal-growth-factor-receptor-egfr-mutations-in-non-small-cell-lung-cancer-nsclc-of-yunnan-in-southwestern-china
#13
Yongchun Zhou, Yanlong Yang, Chenggang Yang, Yunlan Chen, Changshao Yang, Yaxi Du, Guangqiang Zhao, Yinjin Guo, Lianhua Ye, Yunchao Huang
To investigate the Epidermal Growth Factor Receptor (EGFR) mutation status in non-small cell lung cancer (NSCLC) in Yunnan province in southwestern China, we detected EGFR mutation by Amplification Refractory Mutation System (ARMS) polymerase chain reaction (PCR) using DNA samples from 447 pathologically confirmed NSCLC specimens (175 tissue, 256 plasma and 16 cytologic samples). The relationship between EGFR mutations and demographic and clinical factors were further explored. Subgroup analyses according to sample type (tissue and plasma) and histological type (adenocarcinoma) were done...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28079792/amplification-of-her2-and-top2a-and-deletion-of-top2a-genes-in-a-series-of-taiwanese-breast-cancer
#14
Jim-Ray Chen, Hui-Ping Chien, Kuo-Su Chen, Cheng-Cheng Hwang, Huang-Yang Chen, Kun-Yan Yeh, Tsan-Yu Hsieh, Liang-Che Chang, Yuan-Chun Hsu, Ren-Jie Lu, Chung-Ching Hua
BACKGROUND: The prognostic relevance of topoisomerase II alpha (TOP2A) copy number change remains not well established. This study is aimed to investigate the frequency and pattern of TOP2A aberrations; to correlate TOP2A alterations with human epidermal growth factor receptor 2 (HER2) status and clinicopathological parameters, and further to explore prognostic value of TOP2A and HER2 status in breast cancer in Taiwan. METHODS: We analyzed tissue samples from 311 invasive carcinomas in tissue microarrays for TOP2A and HER2 status by fluorescent in situ hybridization...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28073374/successful-multimodal-treatment-of-intraoral-salivary-duct-carcinoma-in-a-patient-with-multiple-lymph-node-metastases-a-case-report
#15
Shuichi Imaue, Kei Tomihara, Takeru Hamashima, Gakuto Tomizawa, Kuninori Nomura, Masakiyo Sasahara, Makoto Noguchi
BACKGROUND: Salivary duct carcinoma (SDC) is a high-grade salivary gland malignancy that is associated with an aggressive clinical behavior and poor prognosis. Herein, we report on a long surviving case of SDC of the minor salivary gland with multiple lymph node metastases (LNMs). CASE PRESENTATION: An 83-year-old woman presented with a history of lymphadenopathy in the right side of the neck and recent onset and rapid growth of a mass in the right buccal region...
January 10, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28072974/-clinicopathologic-features-of-mammary-analogue-secretory-carcinoma-of-salivary-glands
#16
X P Zhang, H Ni, X Wang, H Chen, S S Shi, B Yu, X J Zhou, Q Rao
Objective: To investigate the clinicopathological features of mammary analogue secretory carcinoma (MASC) of salivary glands, and its diagnosis, differential diagnosis, immunohistochemistry and molecular pathology. Methods: Seventeen cases of MASC were enrolled, with 9 cases of salivary acinar cell carcinoma and 18 cases of adenoid cystic carcinoma as control groups from Nanjing General Hospital from 1997 to 2014 were included in this retrospective study, combined with immunohistochemistry and molecular detection of ETV6-NTRK3 gene fusion...
January 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28056854/establishing-a-xenograft-mouse-model-of-peritoneal-dissemination-of-gastric-cancer-with-organ-invasion-and-fibrosis
#17
Mitsuyoshi Okazaki, Sachio Fushida, Shinichi Harada, Tomoya Tsukada, Jun Kinoshita, Katsunobu Oyama, Tomoharu Miyashita, Itasu Ninomiya, Tetsuo Ohta
BACKGROUND: The clinical prognosis of gastric cancer with peritoneal dissemination is poor because of its chemoresistance and rich fibrosis. While several gastric cancer cell lines have been used to establish models of peritoneal dissemination by intraperitoneal injection, most peritoneal tumors that form adopt a medullary pattern in microscopic appearance. This histological finding for the model differs from that in the clinical situation. This study was performed to demonstrate the contribution of human peritoneal mesothelial cells (HPMCs) to fibrotic tumor formation and to establish a new xenograft model with high potential for peritoneal dissemination with organ invasion and extensive fibrosis...
January 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28038793/histologic-characteristics-of-thymic-adenocarcinomas-clinicopathologic-study-of-a-nine-case-series-and-a-review-of-the-literature
#18
Ah-Young Kwon, Joungho Han, Jinah Chu, Yong Soo Choi, Byeong-Ho Jeong, Myung-Ju Ahn, Yong Chan Ahn
Primary thymic adenocarcinoma is an extraordinarily rare malignancy; only 49 cases have been reported in the medical literature to date. Because of its rarity, clinical and pathologic characteristics of thymic adenocarcinoma are unclear. We present nine cases of primary thymic adenocarcinoma and discuss clinicopathologic findings in the context of the existing literature. Two-hundred twenty-six thymic carcinoma cases were diagnosed at Samsung Medical Center in Korea, from January, 2001 to July, 2016. Nine of these 226 cases were primary thymic adenocarcinomas...
November 15, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28034727/diagnosing-colorectal-medullary-carcinoma-interobserver-variability-and-clinicopathological-implications
#19
Lik Hang Lee, Rhonda K Yantiss, Eran Sadot, Bing Ren, Marcela Santos Calvacanti, Jaclyn F Hechtman, Sinisa Ivelja, Be Huynh, Yue Xue, Tatiana Shitilbans, Hamza Guend, Zsofia K Stadler, Martin R Weiser, Efsevia Vakiani, Mithat Gonen, David S Klimstra, Jinru Shia
Colorectal medullary carcinoma, recognized by the World-Health-Organization as a distinct histologic subtype, is commonly regarded as a specific entity with an improved prognosis and unique molecular pathogenesis. A fundamental but as-yet unaddressed question, however, is whether it can be diagnosed reproducibly. In this study, by analyzing 80 colorectal adenocarcinomas whose dominant growth pattern was solid (thus encompassing medullary carcinoma and its mimics), we provided a detailed description of the morphological spectrum from "classic medullary histology" to non-medullary poorly-differentiated histologies and demonstrated significant overlapping between categories...
December 26, 2016: Human Pathology
https://www.readbyqxmd.com/read/28031838/stromal-micropapillary-predominant-lung-adenocarcinoma-a-rare-histological-phenotype-with-poor-prognosis
#20
Takamitsu Hayakawa, Shogo Tajima, Masaru Tsukui, Yusuke Takanashi, Hiroshi Neyatani, Kazuhito Funai
An extremely rare case of stromal micropapillary predominant lung adenocarcinoma is presented in this study. A 70-year-old woman visited our hospital because of an abnormal shadow on chest X-ray. Chest computed tomography revealed a nodule in the left lower lobe and a mass in the left upper lobe. She underwent an exploratory thoracotomy owing to the suspicion of advanced lung cancer. Pathological examination of the left lower lobe nodule revealed tumour cells with more than half the tumour cells showing stromal micropapillary pattern (SMP), consisting of tumour cells invading the fibrotic stroma...
November 2016: Respirology Case Reports
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