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histological growth pattern

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https://www.readbyqxmd.com/read/28532541/-analysis-of-growth-curve-type-in-pulmonary-nodules-with%C3%A2-different-characteristics
#1
Xinyue Wang, Rongcheng Han, Fangfang Guo, Xinling Li, Wensong Zheng, Qing Wang, Wenjing Song, Tielian Yu, Ying Wang
BACKGROUND: Background and objective Follow up by computed tomography (CT) and growth evaluation are routine methods for the differential diagnosis of indeterminate pulmonary nodules in clinical practice. Pulmonary nodules with diverse biological behaviors may show different growth patterns and velocities. The aim of this study is to identify the volume growth curve of both benign and malignant pulmonary nodules. This work also intends to determine these nodules' growth patterns and provide evidence for the establishment of a follow-up strategy...
May 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28530072/-factors-predicting-overall-and-disease-free-survival-after-surgery-for-invasive-bladder-cancer
#2
Eli Fried, Vladimir Yutkin, Dov Pode, Amos Shapiro, Guy Hidas, Ilan Gielchinsky, Ezekiel H Landau, Shilo Rosenberg, Mordechai Duvdevani, Ofer N Gofrit
OBJECTIVES: To evaluate the prognosis of patients who underwent surgery for invasive bladder cancer and to search for prognostic factors. METHODS: The files of all the patients who underwent radical or partial cystectomy for invasive bladder cancer between 1992 and 2014 were reviewed. The effect of various prognostic factors was evaluated by uni- and multivariate analyses. RESULTS: A total of 160 patients were included in the study and were followed for a median period of 25...
November 2016: Harefuah
https://www.readbyqxmd.com/read/28529749/chondroblastic-osteosarcoma-arising-in-the-maxilla-mimicking-the-radiographic-and-histological-characteristics-of-cemento-osseous-lesions-a-case-report
#3
Bin-Bin Li, Jian-Yun Zhang, Yan Gao
Osteosarcomas of the jaw are comparatively rare and represent only 2-10% of all osteosarcomas. We herein present a rare case of an osteosarcoma exhibiting the radiographic and histological characteristics of cemento-osseous lesions in the alveolar ridge of the maxilla. A 53-year-old male patient presented with the complaint of gradual swelling of the left maxilla over 4 years. Radiography revealed an ill-defined radioopaque mass, intimately associated with the apices of the involved teeth, without a periosteal reaction...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28528680/prognostic-factors-of-adenoid-cystic-carcinoma-of-the-head-and-neck-in-carbon-ion-radiotherapy-the-impact-of-histological-subtypes
#4
Hiroaki Ikawa, Masashi Koto, Ryo Takagi, Daniel K Ebner, Azusa Hasegawa, Kensuke Naganawa, Toshinao Takenouchi, Toshitaka Nagao, Takeshi Nomura, Takahiko Shibahara, Hiroshi Tsuji, Tadashi Kamada
PURPOSE: The aim of this study was to evaluate the effect of histological subtypes of head and neck adenoid cystic carcinoma (ACC) on the results of carbon-ion radiotherapy (CIRT). MATERIAL AND METHODS: Of the 113 patients with ACC who were treated with CIRT between December 2006 and July 2013, 100 patients with identified histological subtypes were enrolled in this study. CIRT at a total dose of 57.6 or 64.0Gy (RBE) was administered in 16 fractions. Histological grading was defined as the presence or absence of a solid growth pattern...
May 18, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28522441/encouraging-activity-for-r-chop-in-advanced-stage-nodular-lymphocyte-predominant-hodgkin-lymphoma
#5
Michelle A Fanale, Chan Yoon Cheah, Amy Rich, L Jeffrey Medeiros, Chao-Ming Lai, Yasuhiro Oki, Jorge E Romaguera, Luis Fayad, F B Hagemeister, Felipe Samaniego, Maria A Rodriguez, Sattva S Neelapu, Hun J Lee, Loretta Nastoupil, Nathan Fowler, Francesco Turturro, Jason Westin, Michael Wang, Peter McLaughlin, Chelsea Pinnix, Sarah Milgrom, Bouthaina Dabaja, Sandra B Horowitz, Anas Younes
Nodular lymphocyte Hodgkin lymphoma (NLPHL) is a rare disease for which the optimal therapy is unknown. We hypothesized R-CHOP could decrease rates of relapse and transformation. We retrospectively reviewed patients with NLPHL diagnosed between 1995 and 2015 confirmed by central pathologic review. Fifty-nine had sufficient treatment and follow-up data for analysis. We described progression-free (PFS), overall survival (OS) and histologic transformation according to treatment strategy and explorede prognostic factors for PFS and OS...
May 18, 2017: Blood
https://www.readbyqxmd.com/read/28517044/intercentrum-versus-pleurocentrum-growth-in-early-tetrapods-a-paleohistological-approach
#6
Marylène Danto, Florian Witzmann, Stephanie E Pierce, Nadia B Fröbisch
A variety of vertebral centrum morphologies have evolved within early tetrapods which range from multipartite centra consisting of intercentra and pleurocentra in stem-tetrapods, temnospondyls, seymouriamorphs, and anthracosaurs up to monospondylous centra in lepospondyls. With the present study, we aim to determine the formation of both intercentrum and pleurocentrum and asked whether these can be homologized based on their bone histology. Both intercentra and pleurocentra ossified endochondrally and periosteal bone was subsequently deposited on the outer surface of the centra...
May 18, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28512040/meningiomas-adjacent-to-major-venous-sinuses-clinical-outcome-and-recurrence
#7
Judith Anthofer, Rahel Seidel-Schulz, Alexander Brawanski, Karl-Michael Schebesch
INTRODUCTION: Surgical treatment of meningiomas next to venous sinuses is difficult because of their irregular growth patterns and infiltration into the venous sinuses, therefore making gross total resection impossible in some patients. In this study, we evaluated the postoperative clinical and neurological course of this tumor subgroup. METHODS: This study included 141 consecutive patients with meningioma located within 20 mm to a major venous sinus. We reviewed patient charts and surgical reports for demographics, histology, and clinical and neurological performance pre- and postoperatively and during follow-up...
May 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28506733/variant-morphology-in-upper-urinary-tract-urothelial-carcinoma-a-fourteen-year-case-series-of-biopsy-and-resection-specimens
#8
Hiroyuki Hayashi, Steven Mann, Chia-Sui Kao, David Grignon, Muhammad T Idrees
Upper urinary tract urothelial carcinoma exhibiting variant morphology, especially in higher-grade tumors, is a recognized phenomenon but has not been comparatively studied in biopsy versus resection material. We studied the morphologic patterns and clinicopathological features, and provide a comparison between biopsy and resection specimens. Consultation cases were evaluated separately to investigate for possible consultation bias. A total of 383 in-house cases from 352 patients including 314 resection specimens and 69 biopsies from 2001-2014 were reviewed from a single institution...
May 12, 2017: Human Pathology
https://www.readbyqxmd.com/read/28496398/growth-of-thalamocortical-fibers-to-the-somatosensory-cortex-in-the-human-fetal-brain
#9
Željka Krsnik, Visnja Majić, Lana Vasung, Hao Huang, Ivica Kostović
Thalamocortical (TH-C) fiber growth begins during the embryonic period and is completed by the third trimester of gestation in humans. Here we determined the timing and trajectories of somatosensory TH-C fibers in the developing human brain. We analyzed the periods of TH-C fiber outgrowth, path-finding, "waiting" in the subplate (SP), target selection, and ingrowth in the cortical plate (CP) using histological sections from post-mortem fetal brain [from 7 to 34 postconceptional weeks (PCW)] that were processed with acetylcholinesterase (AChE) histochemistry and immunohistochemical methods...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28488786/gadoxetic-acid-enhanced-magnetic-resonance-imaging-reflects-co-activation-of-%C3%AE-catenin-and-hepatocyte-nuclear-factor-4%C3%AE-in-hepatocellular-carcinoma
#10
Azusa Kitao, Osamu Matsui, Norihide Yoneda, Kazuto Kozaka, Satoshi Kobayashi, Wataru Koda, Tetsuya Minami, Dai Inoue, Kotaro Yoshida, Taro Yamashita, Tatsuya Yamashita, Shuichi Kaneko, Hiroyuki Takamura, Tetsuo Ohta, Hiroko Ikeda, Yasunori Sato, Yasuni Nakanuma, Kenichi Harada, Ryuichi Kita, Toshifumi Gabata
AIM: The aim of this study is to clarify the correlation of the co-activation of β-catenin and hepatocyte nuclear factor (HNF) 4α with the findings of gadoxetic acid enhanced MRI, organic anion transporting polypeptide (OATP) 1B3 expression and histological differentiation grade in hepatocellular carcinoma (HCC). METHODS: Surgically resected 196 HCC in 174 patients were enrolled in this study. HCC were classified into four groups by immunohistochemical expression of β-catenin, glutamine synthetase (GS) and HNF4α: β-catenin/GS (positive: +) HNF4α (+), β-catenin/GS (+) HNF4α (negative: -), β-catenin/GS (-) HNF4α (+) and β-catenin/GS (-) HNF4α (-)...
May 10, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28484537/dorsally-exophytic-glioblastoma-arising-from-the-medulla-oblongata-in-an-adult-presenting-as-4-th-ventricular-mass
#11
Kuntal Kanti Das, Guru Prasad Bettaswamy, Anant Mehrotra, Sushila Jaiswal, Awadhesh Kumar Jaiswal, Sanjay Behari
Brainstem gliomas are relatively rare in adults (<2% of all gliomas). Exophytic gliomas are focal brainstem lesions, which project into the 4(th) ventricle or cerebellopontine angles. These exophytic lesions are usually of low-grade histology (pilocytic astrocytoma or ganglioglioma) and have a relatively better outcome compared with brainstem gliomas as a whole. Glioblastoma is the commonest primary glial cell neoplasm and mostly occurs in the supratentorial compartment. It is rather uncommon in the brainstem and seldom has been described as having an exophytic growth pattern...
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28481062/preclinical-transgenic-and-patient-derived-xenograft-models-recapitulate-the-radiological-features-of-human-adamantinomatous-craniopharyngioma
#12
Jessica K R Boult, John R Apps, Annett Hölsken, J Ciaran Hutchinson, Carreno Gabriela, Laura S Danielson, Laura M Smith, Tobias Bäuerle, Rolf Buslei, Michael Buchfelder, Alex K Virasami, Alexander Koers, Owen J Arthurs, Thomas S Jacques, Louis Chesler, Juan Pedro Martinez-Barbera, Simon P Robinson
AIM: To assess the clinical relevance of transgenic and patient-derived xenograft models of adamantinomatous craniopharyngioma (ACP) using serial magnetic resonance imaging (MRI) and high resolution post-mortem micro-computed tomography (μ-CT), with correlation with histology and human ACP imaging. METHODS: The growth patterns and radiological features of tumours arising in Hesx1(Cre/+) ;Ctnnb1(l) °(x(ex3)/+) transgenic mice, and of patient-derived ACP xenografts implanted in the cerebral cortex, were monitored longitudinally in vivo with anatomical and functional MRI, and by ex vivo μ-CT at study end...
May 8, 2017: Brain Pathology
https://www.readbyqxmd.com/read/28475519/genomic-assessment-of-blitz-nevi-suggests-classification-as-a-subset-of-blue-nevus-rather-than-spitz-nevus-clinical-histopathologic-and-molecular-analysis-of-18-cases
#13
Maria C Isales, Alexandra M Haugh, Jeffrey Bubley, Anna E Verzì, Bin Zhang, Emily Kudalkar, Christina Y Lee, Pedram Yazdan, Joan Guitart, Pedram Gerami
Blitz nevi/tumors are a distinct subset of melanocytic neoplasia which show mixed morphologic features of Spitz and blue nevus. Genomically, most blue nevi have GNAQ or GNA11 mutations while most Spitzoid neoplasms have either an HRAS mutation or translocations involving MET, ROS, BRAF, ALK1, NTRK1, and RET. The criteria used for the assessment of malignancy in blue and Spitzoid lesions are different, and these lesions have different prognostic markers. In this study, we assess the clinical, morphological, and genomic changes in 18 cases of Blitz nevi/tumors to better characterize this subset of neoplasms and determine their optimal genomic classification...
April 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28472963/experimental-approach-to-igf-1-therapy-in-ccl4-induced-acute-liver-damage-in-healthy-controls-and-mice-with-partial-igf-1-deficiency
#14
Luis A Morales-Garza, Juan E Puche, Gabriel A Aguirre, Úrsula Muñoz, Mariano García-Magariño, Rocío G De la Garza, Inma Castilla-Cortazar
BACKGROUND: Cell necrosis, oxidative damage, and fibrogenesis are involved in cirrhosis development, a condition in which insulin-like growth factor 1 (IGF-1) levels are diminished. This study evaluates whether the exogenous administration of low doses of IGF-1 can induce hepatoprotection in acute carbon tetrachloride (CCl4)-induced liver damage compared to healthy controls (Wt Igf (+/+)). Additionally, the impact of IGF-1 deficiency on a damaged liver was investigated in mice with a partial deficit of this hormone (Hz Igf1 (+/-))...
May 4, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28472133/stretch-force-guides-finger-like-pattern-of-bone-formation-in-suture
#15
Bo-Hai Wu, Xiao-Xing Kou, Ci Zhang, Yi-Mei Zhang, Zhen Cui, Xue-Dong Wang, Yan Liu, Da-Wei Liu, Yan-Heng Zhou
Mechanical tension is widely applied on the suture to modulate the growth of craniofacial bones. Deeply understanding the features of bone formation in expanding sutures could help us to improve the outcomes of clinical treatment and avoid some side effects. Although there are reports that have uncovered some biological characteristics, the regular pattern of sutural bone formation in response to expansion forces is still unknown. Our study was to investigate the shape, arrangement and orientation of new bone formation in expanding sutures and explore related clinical implications...
2017: PloS One
https://www.readbyqxmd.com/read/28467498/spatial-regulation-of-bone-morphogenetic-proteins-bmps-in-postnatal-articular-and-growth-plate-cartilage
#16
Presley Garrison, Shanna Yue, Jeffrey Hanson, Jeffrey Baron, Julian C Lui
Articular and growth plate cartilage both arise from condensations of mesenchymal cells, but ultimately develop important histological and functional differences. Each is composed of three layers-the superficial, mid and deep zones of articular cartilage and the resting, proliferative and hypertrophic zones of growth plate cartilage. The bone morphogenetic protein (BMP) system plays an important role in cartilage development. A gradient in expression of BMP-related genes has been observed across growth plate cartilage, likely playing a role in zonal differentiation...
2017: PloS One
https://www.readbyqxmd.com/read/28467018/histological-analysis-of-hyalinised-keloidal-collagen-formation-in-earlobe-keloids-over-time-collagen-hyalinisation-starts-in-the-perivascular-area
#17
Noriko M Matsumoto, Wei-Xia Peng, Masayo Aoki, Satoshi Akaishi, Ryuji Ohashi, Rei Ogawa, Zenya Naito
Keloids grow and do not regress. They are characterised histologically by hyalinised keloidal collagen (HKC). HKC amounts vary, and the mechanism by which they form is unclear. To clarify how HKCs form and whether their formation associates with specific clinical features, we studied the histological findings of earlobe keloids and compared them with respective clinical features. A total of 50 earlobe keloids from 43 patients were used for histological analysis of keloid size (mm(2) ), HKC area (mm(2) ) and HKC area ratio (%)...
May 3, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28464030/screening-candidate-micrornas-mirnas-in-different-lambskin-hair-follicles-in-hu-sheep
#18
Wen Gao, Wei Sun, Jinfeng Yin, Xiaoyang Lv, Jianjun Bao, Jiarui Yu, Lihong Wang, Chengyan Jin, Liang Hu
Hu sheep lambskin is a unique white lambskin from China that exhibits three types of flower patterns, including small waves, medium waves, and large waves, with small waves considered the best quality. However, our understanding of the molecular mechanism underlying flower pattern formation in Hu sheep lambskin is limited. The aim of the present study was to further explore the relevance between candidate microRNAs (miRNAs) and developmental characteristics of hair follicles and screen miRNAs for later functional validation...
2017: PloS One
https://www.readbyqxmd.com/read/28454692/maternal-vascular-malperfusion-of-the-placental-bed-associated-with-hypertensive-disorders-in-the-boston-birth-cohort
#19
Blandine Bustamante Helfrich, Nymisha Chilukuri, Huan He, Sandra R Cerda, Xiumei Hong, Guoying Wang, Colleen Pearson, Irina Burd, Xiaobin Wang
INTRODUCTION: The associations of maternal conditions, before or during pregnancy, with placental lesions have not been adequately studied in populations. METHODS: In the Boston Birth Cohort, we evaluated associations between three maternal medical conditions (hypertensive disorders [HDs], gestational/pre-gestational diabetes and obesity), and placental histological findings, using a standardized classification system proposed by the Amsterdam Placental Workshop Group...
April 2017: Placenta
https://www.readbyqxmd.com/read/28448960/utility-of-genomic-analysis-in-differentiating-synchronous-and-metachronous-lung-adenocarcinomas-from-primary-adenocarcinomas-with-intrapulmonary-metastasis
#20
Jad Saab, Hamid Zia, Susan Mathew, Michael Kluk, Navneet Narula, Helen Fernandes
Distinguishing synchronous and metachronous primary lung adenocarcinomas from adenocarcinomas with intrapulmonary metastasis is essential for optimal patient management. In this study, multiple lung adenocarcinomas occurring in the same patient were evaluated using comprehensive histopathologic evaluation supplemented with molecular analysis. The cohort included 18 patients with a total of 52 lung adenocarcinomas. Eleven patients had a new diagnosis of multiple adenocarcinomas in the same lobe (n=5) or different lobe (n=6)...
June 2017: Translational Oncology
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