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https://www.readbyqxmd.com/read/29931538/alk5-runx1-signaling-mediated-by-extracellular-vesicles-promotes-vascular-repair-in-acute-respiratory-distress-syndrome
#1
Trushil Shah, Shanshan Qin, Mona Vashi, Dan N Predescu, Niranjan Jeganathan, Cristina Bardita, Balaji Ganesh, Salvatore diBartolo, Louis F Fogg, Robert A Balk, Sanda A Predescu
BACKGROUND: Pulmonary endothelial cells' (ECs) injury and apoptotic death are necessary and sufficient for the pathogenesis of the acute respiratory distress syndrome (ARDS), regardless of epithelial damage. Interaction of dysfunctional ECs with circulatory extracellular vesicles (EVs) holds therapeutic promise in ARDS. However, the presence in the blood of long-term ARDS survivors of EVs with a distinct phenotype compared to the EVs of non-surviving patients is not reported. With a multidisciplinary translational approach, we studied EVs from the blood of 33 patients with moderate-to-severe ARDS...
June 22, 2018: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/29931222/a-diffuse-leptomeningeal-glioneuronal-tumor-without-diffuse-leptomeningeal-involvement-detailed-molecular-and-clinical-characterization
#2
Jennifer H Kang, Anne F Buckley, Seema Nagpal, Nancy Fischbein, Katherine B Peters
Prior to their provisional WHO classification as a distinct entity in 2016, diffuse leptomeningeal glioneuronal tumors (DLGNT) were often regarded as diffuse leptomeningeal presentations of oligodendrogliomas or extraventricular neurocytomas. Their classification as a distinct entity partly relies on their pattern of growth, but DLGNTs without radiological leptomeningeal involvement have been described. In a patient with a DLGNT of the spinal cord without evidence of leptomeningeal involvement, we review in depth the clinical course and the histologic and molecular features of the neoplasm, in the context of other reported cases without diffuse leptomeningeal involvement...
June 20, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29915627/anti-inflammatory-biologics-and-anti-tumoral-immune-therapies-associated-colitis-a-focused-review-of-literature
#3
REVIEW
Weixun Zhou, Yan Huang, Jinping Lai, Jun Lu, Michael Feely, Xiuli Liu
An increasing number of drugs including monoclonal antibodies and small molecules, either anti-inflammatory or immunity-enhancing, have been developed to treat human diseases and the number of medications in these classes is likely to expand in the future. The two most commonly used categories of such therapies are the anti-inflammatory group (anti- tumor necrosis factor (TNF) α, anti-interleukins/interleukin receptors, and anti-integrin bodies) and the anti-tumoral agents (immune checkpoint inhibitors, anti-CD20, and anti-endothelial growth factor)...
June 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29907330/blood-flow-patterns-and-pressure-loss-in-the-ascending-aorta-a-comparative-study-on-physiological-and-aneurysmal-conditions
#4
Utku Gülan, Christelle Calen, Firat Duru, Markus Holzner
An aortic aneurysm is defined as a balloon-shaped bulging of all three histologic components of the aortic vessel walls (intima, media and adventitia). This dilation results from vessel weakening owing to remodeling, i.e. due to cystic degeneration of the Tunica media (Marfan), progression of atherosclerosis or presence of a bicuspid aortic valve. The growth rate of the aortic diameter varies from patient to patient and may progress until the aneurysm ultimately ruptures. The role of hemodynamics, i.e. blood flow patterns, and shear stresses that are supposed to intensify during aneurysm growth are not yet fully understood, but thought to play a key role in the enlargement process...
June 8, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29904242/noninvasive-imaging-of-hepatocellular-carcinoma-from-diagnosis-to-prognosis
#5
REVIEW
Han-Yu Jiang, Jie Chen, Chun-Chao Xia, Li-Kun Cao, Ting Duan, Bin Song
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a major public health problem worldwide. Hepatocarcinogenesis is a complex multistep process at molecular, cellular, and histologic levels with key alterations that can be revealed by noninvasive imaging modalities. Therefore, imaging techniques play pivotal roles in the detection, characterization, staging, surveillance, and prognosis evaluation of HCC. Currently, ultrasound is the first-line imaging modality for screening and surveillance purposes...
June 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29894894/excess-deposition-of-collagen-in-mammary-glands-of-tamoxifen-treated-holstein-heifers-is-associated-with-impaired-mammary-growth
#6
H L M Tucker, J Holdridge, C L M Parsons, R M Akers
It is established that the ovary and estrogen are essential to bovine mammary development with the onset of puberty. Recent studies have shown that ovariectomy in the very early prepubertal period, well before onset of puberty, also dramatically impairs mammary growth. Similarly, prepubertal heifers treated with the antiestrogen tamoxifen (TAM) also exhibit markedly impaired mammary growth in correspondence with reduced estrogen receptor α (ESR1) expression. Our objective was to evaluate the effect of TAM on the mammary stroma and specifically to determine if the reported decrease in mammary development was related to changes in TAM-induced alterations in the stroma surrounding the mammary parenchyma...
May 18, 2018: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29892415/enamel-formation-and-growth-in-non-mammalian-cynodonts
#7
Rachel N O'Meara, Wendy Dirks, Agustín G Martinelli
The early evolution of mammals is associated with the linked evolutionary origin of diphyodont tooth replacement, rapid juvenile growth and determinate adult growth. However, specific relationships among these characters during non-mammalian cynodont evolution require further exploration. Here, polarized light microscopy revealed incremental lines, resembling daily laminations of extant mammals, in histological sections of enamel in eight non-mammalian cynodont species. In the more basal non-probainognathian group, enamel extends extremely rapidly from cusp to cervix...
May 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29886587/-histologic-subtyping-of-poorly-differentiated-solid-lung-cancer-with-molecular-testing-for-epidermal-growth-factor-receptor-mutation-and-alk-gene-rearrangement-an-analyses-of-167-cases
#8
F Fang, Y X Wang, S T Hu, L Yang, J Di, D G Liu, N Lyu
Objective: To study the histological subtyping of poorly differentiated solid lung cancer by using immunohistochemistry and mucin staining along with analysis of epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) gene rearrangement. Methods: Among 827 cases of non-small cell lung cancer at Beijing Hospital from April 2014 to April 2017, 167 cases of solid poorly differentiated lung cancer were identified and histopathologically subtyped by mucin staining (D-PAS) and immunohistochemistry using 10 antibodies (CK7, vimentin, Ki-67, CK5/6, p40, TTF1, Napsin A, CD56, chromogranin A, and synaptophysin)...
June 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29884466/-dicer1-mutated-solid-trabecular-thyroid-papillary-carcinoma-in-an-11-year-old-child
#9
Lucie Ravella, Jonathan Lopez, Françoise Descotes, Jean-Christophe Lifante, Catherine David, Myriam Decaussin-Petrucci
We report the case of an 11-year-old patient diagnosed with a solid variant of papillary thyroid carcinoma. Papillary thyroid carcinoma (PTC) is the most common thyroid cancer, representing 80-90% of all newly diagnosed thyroid cancers. Among the many variants described, solid/trabecular variant of papillary thyroid carcinoma is a rare entity and account for 3% of thyroid cancers. It is more common in children and young adults, and it is seen in higher proportion in post radiation papillary thyroid carcinoma cases...
June 5, 2018: Annales de Pathologie
https://www.readbyqxmd.com/read/29882997/clinical-relevance-of-pd-l1-expression-in-gallbladder-cancer-a-potential-target-for-therapy
#10
Azfar Neyaz, Nuzhat Husain, Swati Kumari, Sameer Gupta, Saumya Shukla, Sanya Arshad, Nidhi Anand, Arun Chaturvedi
INTRODUCTION: Gallbladder carcinoma has limited therapeutic options and a poor outcome with conventional therapy. Program death ligand (PD-L1) has been used as a potential target for immune checkpoint inhibitors in various solid neoplasms. PD-L1 expression has been studied in very few cases of gallbladder cancer. MATERIALS AND METHODS: 174 cases of gallbladder carcinoma were evaluated for PD-L1 expression using SP263 clone in tissue microarray. Clinico-pathological characteristics and survival data were correlated with PD-L1 expression analysed at different cut-offs of ≥1%, ≥10% and ≥50% in tumour cells and tumour infiltrating lymphocytes (TILs)...
June 8, 2018: Histopathology
https://www.readbyqxmd.com/read/29869156/histology-proven-recurrence-in-the-lateral-or-central-neck-after-systematic-neck-dissection-for-medullary-thyroid-cancer
#11
Andreas Machens, Kerstin Lorenz, Henning Dralle
PURPOSE: To delineate risk factors for, and examine temporal patterns of, histology-proven recurrent medullary thyroid cancer (MTC) after compartment-oriented surgery. METHODS: Multivariate Cox regression on overall, node, and soft tissue infiltrate recurrence per previously dissected neck compartment. RESULTS: Mean follow-up for the 203 (and 158) patients with central (and ipsilateral lateral) neck dissection was 56.1 months. On multivariate Cox regression, tumor size > 20 mm predicted overall and node recurrence in the central neck, whereas extranodal growth predicted overall and node recurrence in the ipsilateral lateral neck...
June 5, 2018: Endocrine
https://www.readbyqxmd.com/read/29867527/the-reparative-abilities-of-menstrual-stem-cells-modulate-the-wound-matrix-signals-and-improve-cutaneous-regeneration
#12
Jimena Cuenca, Alice Le-Gatt, Valentina Castillo, Jose Belletti, Macarena Díaz, Mónica Kurte G, Paz L Gonzalez, Francisca Alcayaga-Miranda, Christina M A P Schuh, Fernando Ezquer, Marcelo Ezquer, Maroun Khoury
Considerable advances have been made toward understanding the cellular and molecular mechanism of wound healing, however, treatments for chronic wounds remain elusive. Emerging concepts utilizing mesenchymal stem cells (MSCs) from umbilical cord, adipose tissue and bone marrow have shown therapeutical advantages for wound healing. Based on this positive outcome, efforts to determine the optimal sources for MSCs are required in order to improve their migratory, angiogenic, immunomodulatory, and reparative abilities...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29863543/conjunctival-squamous-neoplasia-staging-and-initial-treatment
#13
Claudine Bellerive, Jesse L Berry, Ashley Polski, Arun D Singh
PURPOSE: To evaluate the clinical relevance of the American Joint Committee on Cancer (AJCC) classification in the initial management of squamous neoplasia of the conjunctiva. METHODS: This retrospective study enrolled 95 histopathologically proven cases of treatment-naive conjunctival squamous neoplasia. Tumors were classified into 4 histological groups: conjunctival intraepithelial neoplasia (CIN) with mild dysplasia (grade 1/3), moderate dysplasia (grade 2/3), severe dysplasia (grade 3/3 or carcinoma in situ), and invasive squamous cell carcinoma (SCC)...
May 31, 2018: Cornea
https://www.readbyqxmd.com/read/29851703/acquired-cystic-disease-associated-renal-cell-carcinoma-acd-rcc-a-multiinstitutional-study-of-40-cases-with-clinical-follow-up
#14
Christopher G Przybycin, Holly L Harper, Jordan P Reynolds, Cristina Magi-Galluzzi, Jane K Nguyen, Angela Wu, Ankur R Sangoi, Peter S Liu, Saleem Umar, Rohit Mehra, Xiaochun Zhang, Roni M Cox, Jesse K McKenney
The incidence of renal cell carcinoma (RCC) is known to be higher in patients with end-stage renal disease, including those with acquired cystic kidney disease due to dialysis. Acquired cystic disease (ACD)-associated RCC was recently incorporated into the 2016 WHO Classification of Tumors of the Urinary System and Male Genital Tract as a distinct entity and is reportedly the most common RCC arising in end-stage renal disease. In this study, we sought to further describe clinicopathologic findings in a large series of ACD-RCC, emphasizing histologic features, immunophenotype, clinical outcome, and patterns of disease spread...
May 30, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29848736/epidemiological-characteristics-egfr-status-and-management-patterns-of-advanced-non-small-cell-lung-cancer-patients-the-greek-reason-observational-registry-study
#15
MULTICENTER STUDY
Konstantinos N Syrigos, Vasilis Georgoulias, Konstantinos Zarogoulidis, Paris Makrantonakis, Andriani Charpidou, Christos Christodoulou
BACKGROUND/AIM: Real-world evidence regarding the prevalence of epidermal growth factor receptor (EGFR) mutation-positive status (M+) and the clinicopathological characteristics associated with the presence of EGFR mutations in advanced non-small cell lung cancer (NSCLC) is scarce, especially among Caucasian populations. The present study aimed to bridge this gap, as well as to record treatment patterns and outcomes in routine-care settings. PATIENTS AND METHODS: REASON (NCT01153399) was a prospective study of patients with stage IIIB/IV NSCLC and known EGFR mutation status...
June 2018: Anticancer Research
https://www.readbyqxmd.com/read/29795083/-intraoperative-fluorescence-diagnostics-in-surgery-of-intracranial-meningiomas-analysis-of-101-cases
#16
A A Potapov, S A Goryaynov, G V Danilov, D M Chelushkin, V A Okhlopkov, V N Shimanskiy, Sh T Beshplav, V K Poshataev, L V Shishkina, N E Zakharova, A Spallone, T A Savel'eva, V B Loshchenov
Fluorescence diagnostics has been extensively applied in surgery of malignant brain gliomas. However, the use of this technique in surgery of intracranial meningiomas has remained controversial. OBJECTIVE: The study objective was to assess the sensitivity of 5-aminolevulinic acid-based (5-ALA) fluorescence diagnostics in surgery of brain meningiomas and to clarify the clinical and biological factors that may influence the fluorescent effect. MATERIAL AND METHODS: The study consistently included 101 patients with intracranial meningiomas of various locations who were operated on using 5-ALA...
2018: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/29793421/dietary-aquaculture-by-product-hydrolysates-impact-on-the-transcriptomic-response-of-the-intestinal-mucosa-of-european-seabass-dicentrarchus-labrax-fed-low-fish-meal-diets
#17
Alexandre Leduc, Céline Zatylny-Gaudin, Marie Robert, Erwan Corre, Gildas Le Corguille, Hélène Castel, Antoine Lefevre-Scelles, Vincent Fournier, Enric Gisbert, Karl B Andree, Joël Henry
BACKGROUND: Aquaculture production is expected to double by 2030, and demands for aquafeeds and raw materials are expected to increase accordingly. Sustainable growth of aquaculture will require the development of highly nutritive and functional raw materials to efficiently replace fish meal. Enzymatic hydrolysis of marine and aquaculture raw materials could bring new functionalities to finished products. The aim of this study was to determine the zootechnical and transcriptomic performances of protein hydrolysates of different origins (tilapia, shrimp, and a combination of the two) in European seabass (Dicentrarchux labrax) fed a low fish meal diet (5%), for 65 days...
May 24, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29793116/patterns-of-invasive-growth-in-malignant-gliomas-the-hippocampus-emerges-as-an-invasion-spared-brain-region
#18
Awais A Mughal, Lili Zhang, Artem Fayzullin, Andres Server, Yuping Li, Yingxi Wu, Rainer Glass, Torstein Meling, Iver A Langmoen, Trygve B Leergaard, Einar O Vik-Mo
BACKGROUND: Widespread infiltration of tumor cells into surrounding brain parenchyma is a hallmark of malignant gliomas, but little data exist on the overall invasion pattern of tumor cells throughout the brain. METHODS: We have studied the invasive phenotype of malignant gliomas in two invasive mouse models and patients. Tumor invasion patterns were characterized in a patient-derived xenograft mouse model using brain-wide histological analysis and magnetic resonance (MR) imaging...
May 21, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29783798/-prognosis-related-clinicopathologic-characteristics-of-figo-stage-%C3%A2-m%C3%A3-llerian-adenosarcoma-of-uterus
#19
Y Wang, A J Liu, X Chen, X Song
Objective: To investigate the clinicopathological features of FIGO stage Ⅰ uterine Müllerian adenosarcoma and clinical prognosis. Methods: Fifteen cases of uterine Müllerian adenosarcoma at FIGO stage Ⅰ were collected at PLA General Hospital from 2005 to 2017. Twelve cases with complete follow-up data were divided into 2 groups: group A (7 patients with survival) and group B(5 patients of death or tumor progression). Clinicopathologic features were compared between the two groups. Results: The median age of the patients was 43 years and 56 years, and the tumor size was 4...
May 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29770932/clinical-and-pathologic-characteristics-of-pulmonary-carcinoid-tumors-in-central-and-peripheral-locations
#20
George Papaxoinis, Angela Lamarca, Anne Marie Quinn, Wasat Mansoor, Daisuke Nonaka
Pulmonary carcinoid tumors occur in both central and peripheral locations, and some differences in clinico-pathological features have long been observed. We investigated a large number of resected carcinoid tumors with the aim to further define the characteristics of tumors from both locations. One hundred sixty-six resected carcinoid tumors of the lung were analyzed for a variety of clinical and pathologic features, including histology subtype, mitotic rate, Ki67 index, necrosis, invasive pattern, architectural pattern, cell morphology, sustentacular cells, neuroendocrine hyperplasia, and orthopedia homeobox protein (OTP) and TTF-1 immunohistochemical expressions...
May 16, 2018: Endocrine Pathology
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