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histological growth pattern

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https://www.readbyqxmd.com/read/29453963/significance-of-spread-through-air-spaces-in-resected-pathological-stage-i-lung-adenocarcinoma
#1
Gouji Toyokawa, Yuichi Yamada, Tetsuzo Tagawa, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Yoshinao Oda, Yoshihiko Maehara
BACKGROUND: Spread through air spaces (STAS) is a recently described invasive pattern of lung cancer, which spreads within air spaces beyond the edge of the main tumor. In the current study, we investigated the significance of STAS in patients with pathological stage I adenocarcinoma. METHODS: STAS was assessed in a total of 276 patients with resected pathological stage I adenocarcinoma. STAS was classified as either no STAS, low STAS (1-4 single cells or clusters of STAS), or high STAS (≥5 single cells or clusters of STAS) using a 20x objective and a 10x ocular lens...
February 14, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29439708/possible-relationship-between-fibrosis-of-igg4-related-thymitis-and-the-profibrotic-cytokines-transforming-growth-factor-beta-1-interleukin-1-beta-and-interferon-gamma-a-case-report
#2
Atsuko Masunaga, Fumihiro Ishibashi, Eitetsu Koh, Takashi Oide, Yasuo Sekine, Kenzo Hiroshima
BACKGROUND: IgG4-related disease often forms a mass and the affected lesion is clinically removed because the mass cannot be differentiated from a neoplasm. Affected lesions commonly occur in the pancreas, hepatobiliary tract, kidney, and retroperitoneum. However, the lesion rarely occurs in the thymus. A histological worldwide consensus of IgG4-related disease proposed that pathological diagnosis of IgG4-related disease should meet more than two of three major features: 1) dense lymphoplasmacytic infiltration with greater than 40% IgG4+/IgG+ plasma cells, 2) storiform fibrosis; and 3) obliterative phlebitis...
January 17, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29435023/primary-malignant-perivascular-epithelioid-cell-neoplasm-pecoma-of-the-bone-mimicking-granular-cell-tumor-in-core-biopsy-a-case-report-and-literature-review
#3
Sam Sadigh, Preya Shah, Kristy Weber, Ronnie Sebro, Paul J Zhang
The present study investigated the case of a 46-year-old female with primary malignant perivascular epithelioid cell neoplasm (PEComa) of the femur. The patient presented with a 5-month history of right distal thigh pain following trauma. Radiographs of the right distal femur revealed a mixed lytic and sclerotic lesion with subtle areas of cortical destruction and soft tissue extension, consistent with an aggressive tumor. A core biopsy revealed an epithelioid tumor with granular cell features, but a definitive diagnosis could not be made...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433159/prognostic-utility-of-histological-growth-patterns-of-colorectal-lung-oligometastases
#4
Son Jae Yeong, Min Gyoung Pak, Hyoun Wook Lee, Seung Yeon Ha, Mee Sook Roh
Background: Patients with resectable colorectal lung oligometastases demonstrate a heterogeneous oncological outcome. However, the parameters for predicting tumor aggressiveness have not yet been fully investigated in colorectal lung metastases (CLM). This study was performed to determine the prognostic value of histological growth patterns in patients who underwent surgery for CLM. Materials and Methods: The study included 92 patients who were diagnosed with CLM among the first resection cases...
February 12, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29424427/three-molecular-pathways-model-colorectal-carcinogenesis-in-lynch-syndrome
#5
Aysel Ahadova, Richard Gallon, Johannes Gebert, Alexej Ballhausen, Volker Endris, Martina Kirchner, Albrecht Stenzinger, John Burn, Magnus von Knebel Doeberitz, Hendrik Bläker, Matthias Kloor
Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes. MMR deficiency has long been regarded as a secondary event in the pathogenesis of Lynch syndrome colorectal cancers. Recently, this concept has been challenged by the discovery of MMR-deficient crypt foci in the normal mucosa. We aimed to reconstruct colorectal carcinogenesis in Lynch syndrome by collecting molecular and histology evidence from Lynch syndrome adenomas and carcinomas. We determined the frequency of MMR deficiency in adenomas from Lynch syndrome mutation carriers by immunohistochemistry and by systematic literature analysis...
February 9, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29409666/growth-factors-fgf8-and-fgf2-and-their-receptor-fgfr1-transcriptional-factors-msx-1-and-msx-2-and-apoptotic-factors-p19-and-rip5-participate-in-the-early-human-limb-development
#6
Tina Becic, Darko Kero, Katarina Vukojevic, Snjezana Mardesic, Mirna Saraga-Babic
The expression pattern of fibroblast growth factors FGF8 and FGF2 and their receptor FGFR1, transcription factors MSX-1 and MSX-2, as well as cell proliferation (Ki-67) and cell death associated caspase-3, p19 and RIP5 factors were analyzed in histological sections of eight 4th-9th-weeks developing human limbs by immunohistochemistry and semi-thin sectioning. Increasing expression of all analyzed factors (except FGF8) characterized both the multilayered human apical ectodermal ridge (AER), sub-ridge mesenchyme (progress zone) and chondrocytes in developing human limbs...
February 3, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/29409495/pd-1-axis-expression-in-musculoskeletal-tumors-and-antitumor-effect-of-nivolumab-in-osteosarcoma-model-of-humanized-mouse
#7
Bingxin Zheng, Tingting Ren, Yi Huang, Kunkun Sun, Shidong Wang, Xing Bao, Kuisheng Liu, Wei Guo
BACKGROUND: Immune checkpoint inhibitors have led to a breakthrough in solid tumor immunotherapy, but related studies on musculoskeletal tumors are few, especially for PD-L2. METHODS: We examined expression of three molecular effectors of the PD-1 axis in 234 patients with musculoskeletal tumors, including osteosarcoma, chondrosarcoma, synovial sarcoma, and giant cell tumor. Survival analyses and potential mechanisms were investigated in osteosarcoma per the Gene Expression Omnibus (GEO) and immunohistochemistry analyses...
February 6, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29398438/angiogenesis-research-in-mouse-mammary-cancer-based-on-contrast-enhanced-ultrasonography-exploratory-study
#8
Ming Wang, Hai-Liang Feng, Yu-Qin Liu, He Liu, Yu-Xin Jiang, Qing-Li Zhu, Qing Dai, Jian-Chu Li
RATIONALE AND OBJECTIVES: The objective of this study was to investigate the contrast-enhanced ultrasound (CEUS) characteristics of tumor angiogenesis in mouse mammary cancer. MATERIALS AND METHODS: Twenty-four mice were examined with ultrasound and CEUS at 2-12 days after implantation. Four to five mice were assessed daily, and one to three mice were then sacrificed for histology. All of the histologic slides were reviewed and correlated with CEUS findings. RESULTS: A total of 46 cases of ultrasound examination had been performed in 24 mice...
February 2, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29396786/histopathology-ditch-the-slides-because-digital-and-3d-are-on-show
#9
Ilaria Jansen, Marit Lucas, C Dilara Savci-Heijink, Sybren L Meijer, Henk A Marquering, Daniel M de Bruin, Patricia J Zondervan
Due to the growing field of digital pathology, more and more digital histology slides are becoming available. This improves the accessibility, allows teleconsultations from specialized pathologists, improves education, and might give urologist the possibility to review the slides in patient management systems. Moreover, by stacking multiple two-dimensional (2D) digital slides, three-dimensional volumes can be created, allowing improved insight in the growth pattern of a tumor. With the addition of computer-aided diagnosis systems, pathologist can be guided to regions of interest, potentially reducing the workload and interobserver variation...
February 2, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29391927/rat-model-of-anal-sphincter-injury-and-two-approaches-for-stem-cell-administration
#10
Jacobo Trébol, Tihomir Georgiev-Hristov, Luz Vega-Clemente, Ignacio García-Gómez, Ana Carabias-Orgaz, Mariano García-Arranz, Damián García-Olmo
AIM: To establish a rat model of anal sphincter injury and test different systems to provide stem cells to injured area. METHODS: Adipose-derived stem cells (ASCs) were isolated from BDIX rats and were transfected with green fluorescent protein (GFP) for cell tracking. Biosutures (sutures covered with ASCs) were prepared with 1.5 x 10 6 GFP-ASCs, and solutions of 10 6 GFP-ASCs in normal saline were prepared for injection. Anorectal normal anatomy was studied on Wistar and BDIX female rats...
January 26, 2018: World Journal of Stem Cells
https://www.readbyqxmd.com/read/29383295/alteration-of-the-ki-67-proliferative-index-following-surgical-resection-with-or-without-radiation-therapy-of-intracranial-meningiomas
#11
Amir H Faraji, Daniel A Tonetti, John C Flickinger, Johnathan A Engh
The Ki-67 proliferative index is a widely accepted assay for cycling cells within tumor specimens of multiple histological subtypes. While it is not a substitute for the World Health Organization (WHO) grading, the Ki-67 proliferative index is thought to correlate with the biological activity of selected tumors. In the case of intracranial meningiomas, many lesions may be resected multiple times, with radiation therapy juxtaposed between surgical procedures. A retrospective review of 3,900 consecutive patients undergoing intracranial surgical resection at the University of Pittsburgh Medical Center over a five year period was undertaken...
November 23, 2017: Curēus
https://www.readbyqxmd.com/read/29382006/pure-acinic-cell-carcinoma-of-the-breast-a-case-report-and-literature-review
#12
Hongmei Li, Fuzhi Wang, Pingrong Shen, Feng Zhou
RATIONALE: Acinic cell carcinoma (AcCC) of the breast is a rare histological type of malignant epithelial neoplasm exhibiting acinic cell differentiation. PATIENT CONCERNS: A 52-year-old woman presented to the hospital with a palpable mass over the upper outer quadrant of the right breast. DIAGNOSES: Physical examination revealed an irregular mass in the lateral upper quadrant of the left breast, approximately 1.5 cm in diameter. Histologically, the tumor cells were round to oval, had displaced nuclei with striking single nucleoli and basophilic cytoplasm, and contained large coarse cytoplasmic granules...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29374706/the-mesenchymal-epithelial-and-epithelial-mesenchymal-cellular-plasticity-of-liver-metastases-with-digestive-origin
#13
Amalia Raluca Ceausu, Alexandru Ciolofan, Anca Maria Cimpean, Adina Magheti, Ovidiu Mederle, Marius Raica
BACKGROUND: Few data are available regarding the epithelial to mesenchymal transition (EMT) /mesenchymal to epitheilal transition (MET) in the liver metastasis of digestive cancers. The aim of this study was to establish EMT/MET metastatic tumor cell plasticity according to the histological growth pattern of liver metastases. MATERIALS AND METHODS: Biopsies from 25 patients with liver metastasis (desmoplastic, replacement and pushing type) were evaluated. Double immunostaining of E-cadherin/vimentin, keratin 8,18/vimentin and E-cadherin/ keratin 8,18 were performed...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29367756/pax3-foxo1-drives-mir-486-5p-and-represses-mir-221-contributing-to-pathogenesis-of-alveolar-rhabdomyosarcoma
#14
Jason A Hanna, Matthew R Garcia, Alicia Lardennois, Patrick J Leavey, Dino Maglic, Alexandre Fagnan, Jonathan C Go, Jordan Roach, Yong-Dong Wang, David Finkelstein, Mark E Hatley
Rhabdomyosarcoma is the most common soft-tissue sarcoma in childhood and histologically resembles developing skeletal muscle. Alveolar rhabdomyosarcoma (ARMS) is an aggressive subtype with a higher rate of metastasis and poorer prognosis. The majority of ARMS tumors (80%) harbor a PAX3-FOXO1 or less commonly a PAX7-FOXO1 fusion gene. The presence of either the PAX3-FOXO1 or PAX7-FOXO1 fusion gene foretells a poorer prognosis resulting in clinical re-classification as either fusion-positive (FP-RMS) or fusion-negative RMS (FN-RMS)...
January 25, 2018: Oncogene
https://www.readbyqxmd.com/read/29363129/developmental-patterns-and-variation-among-early-theropods
#15
C T Griffin
Understanding ontogenetic patterns is important in vertebrate paleontology because the assessed skeletal maturity of an individual often has implications for paleobiogeography, species synonymy, paleobiology, and body size evolution of major clades. Further, for many groups the only means of confidently determining ontogenetic status of an organism is through the destructive process of histological sampling. Although the ontogenetic patterns of Late Jurassic and Cretaceous dinosaurs are better understood, knowledge of the ontogeny of the earliest dinosaurs is relatively poor because most species-level growth series known from these groups are small (usually, maximum of n ~ 5) and incomplete...
January 23, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29359023/primary-biliary-cholangitis-metachronously-complicated-with-combined-hepatocellular-carcinoma-cholangiocellular-carcinoma-and-hepatocellular-carcinoma
#16
Ryuta Ide, Akihiko Oshita, Takashi Nishisaka, Hideki Nakahara, Shiomi Aimitsu, Toshiyuki Itamoto
Primary biliary cholangitis (PBC) is a progressive cholestatic liver disease characterized by the presence of highly specific antimitochondrial antibodies, portal inflammation and lymphocyte-dominated destruction of the intrahepatic bile ducts, which leads to cirrhosis. While its pathogenesis remains unclear, PBC that shows histological progression to fibrosis carries a high risk of carcinogenesis; the same is true of viral liver diseases. In patients with PBC, the development of hepatocellular carcinoma (HCC) is rare; the development of combined hepatocellular carcinoma and cholangiocellular carcinoma (cHCC-CCC) is extraordinary...
December 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/29351089/aggressive-variants-of-papillary-thyroid-carcinoma-hobnail-tall-cell-columnar-and-solid
#17
Meryl C Nath, Lori A Erickson
Papillary thyroid carcinomas are the most common endocrine cancer and are usually associated with good survival. However, some variants of papillary thyroid carcinomas may behave more aggressively than classic papillary thyroid carcinomas. The tall cell variant of papillary thyroid carcinoma is the most common aggressive variant of papillary thyroid carcinoma. The aggressive behavior has been ascribed to the histologic subtype and/or to the clinicopathologic features, an issue that remains controversial. The columnar variant of papillary thyroid carcinoma can be aggressive, particularly in older patients, with larger tumors showing a diffusely infiltrative growth pattern and extrathyroidal extension...
January 18, 2018: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/29339213/nrp-2-in-tumor-lymphangiogenesis-and-lymphatic-metastasis
#18
Jingwen Wang, Yuhong Huang, Jun Zhang, Boyi Xing, Wei Xuan, Honghai Wang, He Huang, Jiayu Yang, Jianwu Tang
Neuropilin-2 (NRP-2) not only functions as a receptor for semaphorins, a family of neural axon guidance factors, but also interacts with VEGFs, a family of vascular endothelial growth factors. As an independent receptor or a co-receptor, NRP-2 binds to ligands VEGF-C/D, activates the VEGF-C/D-NRP-2 signaling axis, and further regulates lymphangiogenesis-associated factors in both lymphatic endothelial cells (LECs) and some tumor cells during tumor progression. Via VEGF-C/D-NRP-2 axis, NRP-2 induces LEC proliferation, reconstruction and lymphangiogenesis and subsequently promotes tumor cell migration, invasion and lymphatic metastasis...
January 12, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29339175/primary-thymic-adenocarcinomas-a-clinicopathological-and-immunohistochemical-study-of-16-cases-with-emphasis-on-the-morphological-spectrum-of-differentiation
#19
Neda Kalhor, Cesar A Moran
Sixteen cases of primary thymic adenocarcinoma are presented. The patients are 9 men and 7 women between the ages of 22 and 68 years (average: 45 years) who presented with non-specific symptoms including cough, chest pain, and dyspnea. Diagnostic imaging revealed the presence of an anterior mediastinal mass, which was surgically removed in all of the patients. Histologically, none of the tumors was encapsulated and showed different growth patterns including mucinous, non-mucinous, and papillary features. The majority of cases showed mixed growth pattern and the tumor was limited to the mediastinum with only a few cases extending to lymph nodes or pericardium...
January 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29323728/3d-reconstruction-of-prostate-cancer-architecture-with-serial-immunohistochemical-sections-hallmarks-of-tumour-growth-tumour-compartmentalization-and-implications-for-grading-and-heterogeneity
#20
Yuri Tolkach, Stefan Thomann, Glen Kristiansen
BACKGROUND: Conventional morphology of the prostate cancer (PCA) considers only two-dimensional architecture of the tumour. Our aim was to examine the feasibility of 3D-reconstruction of tumour morphology based on multiple consecutive histological sections and to decipher relevant features of PCA architecture. METHODS: Seventy-five consecutive histological sections (5μm) of a typical prostate adenocarcinoma (Gleason-Score 3+4=7) were immunostained (Pan-Cytokeratin) and scanned for further 3D reconstructions with Fiji / ImageJ software...
January 11, 2018: Histopathology
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