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https://www.readbyqxmd.com/read/29676801/prolonged-prenatal-hypoxia-selectively-disrupts-collecting-duct-patterning-and-postnatal-function-in-male-mouse-offspring
#1
Sarah L Walton, Reetu R Singh, Melissa H Little, Josephine Bowles, Joan Li, Karen M Moritz
KEY POINTS SUMMARY: In this study we investigated whether hypoxia during late pregnancy impairs kidney development in mouse offspring, and also whether this has long-lasting consequences affecting kidney function in adulthood. Hypoxia disrupted growth of the kidney, particularly the collecting duct network, in juvenile male offspring. By mid-late adulthood, these mice developed early signs of kidney disease, notably a compromised response to water deprivation. Female offspring showed no obvious signs of impaired kidney development and did not develop kidney disease, suggesting a underlying protection mechanism from the hypoxia insult...
April 20, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29675587/a-case-of-gastric-neuroendocrine-neoplasm-with-mixed-grade-a-distinct-type-of-high-grade-well-differentiated-neuroendocrine-neoplasm
#2
Elia Guadagno, Gaetano Luglio, Alessandro Iacobelli, Giorgio Borrelli, Antonio Castaldi, Gaetano De Rosa, Marialaura Del Basso De Caro
Grade 3 neuroendocrine tumor (NET G3) is a rare new entity that has recently been introduced in the classification of neuroendocrine neoplasms of the pancreas. It is a well-differentiated form, with a high proliferative activity (Ki67 > 20%), and it represents a category whose prognosis is intermediate between NET G2 and poorly differentiated neuroendocrine carcinoma (NEC G3). In sites other than the pancreas, this new category is by far less coded. Herein is reported a case of NET G3 of the stomach, the 13th described in literature...
April 19, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/29669189/multi-method-approach-to-the-early-postnatal-growth-of-the-mandible-in-mice-from-a-zone-of-robertsonian-polymorphism
#3
Jessica Martínez-Vargas, Francesc Muñoz-Muñoz, María José López-Fuster, Jorge Cubo, Jacint Ventura
The western European house mouse (Mus musculus domesticus) shows high karyotypic diversity owing to Robertsonian translocations. Morphometric studies conducted with adult mice suggest that karyotype evolution due to these chromosomal reorganizations entails variation in the form and the patterns of morphological covariation of the mandible. However, information is much scarcer regarding the effect of these rearrangements on the growth pattern of the mouse mandible over early postnatal ontogeny. Here we compare mandible growth from the second to the eighth week of postnatal life between two ontogenetic series of mice from wild populations, with the standard karyotype and with Robertsonian translocations respectively, reared under the same conditions...
April 18, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29666970/histopathological-and-molecular-predictors-of-growth-patterns-and-recurrence-in-craniopharyngiomas-a-systematic-review
#4
REVIEW
Josephine R Coury, Brittany N Davis, Christoforos P Koumas, Giovanna S Manzano, Amir R Dehdashti
Craniopharyngiomas (CPs) are rare, benign tumors derived from Rathke's pouch, known for their high recurrence rates and associated morbidity and mortality. Despite significant investigation on risk factors for recurrence, a lack of consensus persists. Recent research suggests that specific histopathological and molecular characteristics are prognostic for disease progression. In this systematic review, we analyzed and consolidated key features of CPs that contribute to increased recurrence rates. This systematic review was performed in accordance with PRISMA guidelines...
April 17, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29665134/the-role-of-bmp2-in-the-maturation-and-maintenance-of-the-murine-knee-joint
#5
Laura W Gamer, Steven Pregizer, Jackson Gamer, Marina Feigenson, Andreia Ionescu, Qing Li, Lin Han, Vicki Rosen
Bone morphogenetic proteins (BMPs) are key regulators of skeletal development, growth and repair. While BMP signaling is required for synovial joint formation and is also involved in preserving joint function after birth, the role of specific BMP ligands in adult joint homeostasis remains unclear. The purpose of this study was to define the role of Bmp2 in the morphogenesis and maintenance of the knee joint. To do this, we first created Bmp2-LacZ and Gdf5-LacZ knock-in mice and compared their expression patterns in the developing and postnatal murine knee joint...
April 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29662006/hyperinsulinemia-promotes-esophageal-cancer-development-in-a-surgically-induced-duodeno-esophageal-reflux-murine-model
#6
Diletta Arcidiacono, Arben Dedja, Cinzia Giacometti, Matteo Fassan, Daniele Nucci, Simona Francia, Federico Fabris, Alice Zaramella, Emily J Gallagher, Mauro Cassaro, Massimo Rugge, Derek LeRoith, Alfredo Alberti, Stefano Realdon
Hyperinsulinemia could have a role in the growing incidence of esophageal adenocarcinoma (EAC) and its pre-cancerous lesion, Barrett's Esophagus, a possible consequence of Gastro-Esophageal Reflux Disease. Obesity is known to mediate esophageal carcinogenesis through different mechanisms including insulin-resistance leading to hyperinsulinemia, which may mediate cancer progression via the insulin/insulin-like growth factor axis. We used the hyperinsulinemic non-obese FVB/N (Friend leukemia virus B strain) MKR (muscle (M)-IGF1R-lysine (K)-arginine (R) mouse model to evaluate the exclusive role of hyperinsulinemia in the pathogenesis of EAC related to duodeno-esophageal reflux...
April 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29661717/primary-breast-carcinomas-with-neuroendocrine-features-clinicopathological-features-and-analysis-of-tumor-growth-patterns-in-36-cases
#7
Canan Kelten Talu, Cem Leblebici, Tulin Kilicaslan Ozturk, Ezgi Hacihasanoglu, Sevim Baykal Koca, Zuhal Gucin
Primary breast carcinoma with neuroendocrine features (NEBC) is an uncommon tumor. In the classification of WHO 2012, these tumors were categorized as: 1- neuroendocrine tumor, well-differentiated; 2- neuroendocrine carcinoma, poorly differentiated/small cell carcinoma; and 3- invasive breast carcinoma with neuroendocrine differentiation. In this study, we reviewed NEBC except poorly differentiated/small cell carcinoma variant in order to define the morphological growth patterns and cytonuclear details of these tumors...
April 4, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29661289/a-nomogram-to-predict-lymph-node-metastasis-before-resection-in-intrahepatic-cholangiocarcinoma
#8
Ze-Wu Meng, Xiu-Quan Lin, Jin-Hai Zhu, Sheng-Hua Han, Yan-Ling Chen
BACKGROUND: In this study, we developed and validated a nomogram to predict lymph node metastasis before surgery in patients with intrahepatic cholangiocarcinoma (ICC). METHODS: Using the data from January 2006 to January 2015, we enrolled a total of 218 eligible patients with clinicopathologically confirmed ICC as a primary cohort to develop the nomogram. After various variables before surgery were analyzed by multivariable logistic regression, we combined the preoperative carbohydrate antigen 19-9, primary site of tumor, lymphonodus size on computed tomography imaging, tumor growth pattern, and (if applicable) histologic grade to make two different predictive nomograms...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29650547/-in-vivo-growth-of-60-non-screening-detected-lung-cancers-a-computed-tomography-study
#9
Onno M Mets, Kaman Chung, Pieter Zanen, Ernst T Scholten, Wouter B Veldhuis, Bram van Ginneken, Mathias Prokop, Cornelia M Schaefer-Prokop, Pim A de Jong
Current pulmonary nodule management guidelines are based on nodule volume doubling time, which assumes exponential growth behaviour. However, this is a theory that has never been validated in vivo in the routine-care target population. This study evaluates growth patterns of untreated solid and subsolid lung cancers of various histologies in a non-screening setting.Growth behaviour of pathology-proven lung cancers from two academic centres that were imaged at least three times before diagnosis (n=60) was analysed using dedicated software...
April 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29627048/pathology-of-primary-tracheobronchial-malignancies-other-than-adenoid-cystic-carcinomas
#10
REVIEW
Darroch Moores, Paresh Mane
Most primary tracheal tumors are malignant. Malignancy of larynx and bronchi are much more likely than trachea. Tracheal tumors are most likely due to direct extension for surrounding tumors. Squamous cell carcinoma and adenoid cystic carcinoma make up about two-thirds of adult primary tracheal tumors. Because of their predominantly local growth pattern, malignant salivary gland-type tumors show a better outcome than other histologic types.
May 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29624900/air-bronchogram-in-pleomorphic-carcinoma-of-the-lung-is-associated-with-favorable-prognosis
#11
Hideko Onoda, Tokuhiro Kimura, Hiroyuki Tao, Kazunori Okabe, Tsuneo Matsumoto, Eiji Ikeda
BACKGROUND: Pleomorphic carcinoma (PC) of the lung is a rare histological type of lung carcinoma. The association between computed tomography (CT) findings and histology with outcome remains unclear. We examined the relationships between CT features and histopathologic findings, and evaluated the impact of CT features and other clinicopathologic factors on survival. METHODS: Thirty-five consecutive patients with PC of the lung who underwent surgery between October 2010 and December 2015 were enrolled in this study...
April 6, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29622080/targeted-therapy-and-immunotherapy-in-the-treatment-of-non-small-cell-lung-cancer
#12
REVIEW
Girish S Shroff, Patricia M de Groot, Vassiliki A Papadimitrakopoulou, Mylene T Truong, Brett W Carter
The treatment strategy in advanced non-small cell lung cancer (NSCLC) has evolved from empirical chemotherapy to a personalized approach based on histology and molecular markers of primary tumors. Targeted therapies are directed at the products of oncogenic driver mutations. Immunotherapy facilitates the recognition of cancer as foreign by the host immune system, stimulates the immune system, and alleviates the inhibition that allows the growth and spread of cancer cells. The authors describes the role of targeted therapy and immunotherapy in the treatment of NSCLC, patterns of disease present on imaging studies, and immune-related adverse events encountered with immunotherapy...
May 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29611160/stress-induced-changes-in-the-aged-rat-adrenal-cortex-histological-and-histomorphometric-study
#13
Sherif Mohamed Zaki, Fayza Abdelraouf Abdelgawad, Ehab Abdel Aziz El-Shaarawy, Rasha Abdel Khalek Radwan, Basma Emad Aboul-Hoda
BACKGROUND: Stress exposure exerts direct effects on the morphology and functionality of the adrenal cortex. In addition, aging effects growth, differentiation, apoptosis and cellularity of the cortex. The missing data is the combined effect of stress and aging on the adrenal cortex. The aim of this study was to demonstrate the structural changes in the adrenal cortex following the exposure to stress in the adult and aged albino rats. MATERIAL AND METHODS: 40 rats were divided into groups I, II (adult and senile)...
April 3, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29604293/immune-cell-production-of-interleukin-17-induces-stem-cell-features-of-pancreatic-intraepithelial-neoplasia-cells
#14
Yu Zhang, Michelle Zoltan, Erick Riquelme, Hanwen Xu, Ismet Sahin, Susana Castro-Pando, Maria Fernanda Montiel, Kyle Chang, Zhengyu Jiang, Jianhua Ling, Sonal Gupta, William Horne, Melissa Pruski, Huamin Wang, Shao-Cong Sun, Guillermina Lozano, Paul Chiao, Anirban Maitra, Steven D Leach, Jay K Kolls, Eduardo Vilar Sanchez, Timothy C Wang, Jennifer M Bailey, Florencia McAllister
BACKGROUND & AIMS: Little is known about how the immune system affects stem cell features of pancreatic cancer cells. Immune cells that produce interleukin 17 A (IL17A) in the chronically inflamed pancreas (chronic pancreatitis) contribute to PanIN initiation and progression. We investigated the effects of IL17A signaling exerts on pancreatic cancer progenitor cells and the clinical relevance of this phenomena. METHODS: We performed studies with Mist1Cre;LSLKras;Rosa26mTmG (KCiMist ;G) and Kras(G12D); Trp53(R172H); Pdx1-Cre (KPC) mice (which upon tamoxifen induction spontaneously develop pancreatic intraepithelial neoplasias, PanINs) and control littermates...
March 28, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29601841/intratumoral-and-peritumoral-lymphovascular-invasion-detected-by-d2-40-immunohistochemistry-correlates-with-metastasis-in-primary-cutaneous-merkel-cell-carcinoma
#15
Rami N Al-Rohil, Denái R Milton, Priyadharsini Nagarajan, Jonathan L Curry, Laurence Feldmeyer, Carlos A Torres-Cabala, Doina Ivan, Victor G Prieto, Michael T Tetzlaff, Phyu P Aung
Primary cutaneous Merkel cell carcinoma (MCC) is an aggressive neuroendocrine malignancy in which lymphovascular invasion (LVI) correlates with more aggressive phenotype. The prognostic significance of LVI detected by D2-40 immunohistochemistry (IHC) in MCC remains controversial. We aimed to determine how LVI detected by D2-40 IHC compares with LVI detected by hematoxylin-eosin (H&E) staining in predicting MCC metastasis. Clinical and histopathologic features of MCCs diagnosed and treated during 2002-2015 were assembled and included 58 MCC tumors from 58 patients...
March 27, 2018: Human Pathology
https://www.readbyqxmd.com/read/29600037/editorial-on-growth-patterns-of-pulmonary-metastases-should-we-adjust-resection-techniques-to-primary-histology-and-size
#16
EDITORIAL
Stefano M M Basso, Sandro C Sulfaro, Paolo Ubiali
No abstract text is available yet for this article.
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29599626/benign-sebaceous-epithelioma-with-carcinoid-like-trabecular-cell-arrangement
#17
Shuji Suzuki, Kazunari Sugita, Tatsushi Shiomi, Osamu Yamamoto
A case of 75-year-old woman with sebaceous epithelioma was reported. The histological features were distinct in that it had a sinusoidal and carcinoid-like growth pattern, which has been reported in its malignant counterpart. Immunostaining for adipophilin was positive in the area with lipid-laden vacuolated cells, but the rest of tumor, which had cord-like nests, was negative. MIB index was 2%. CK5/6 and p40 were positive in the cord-like nesting areas. CK7, CK20, alpha SMA, and epithelial membrane antigen were negative in both the cord-like nesting areas and the adipose-like areas...
March 2018: Yonago Acta Medica
https://www.readbyqxmd.com/read/29594028/on-cribriform-prostate-cancer
#18
REVIEW
Charlotte F Kweldam, Theodorus van der Kwast, Geert J van Leenders
The management of newly diagnosed prostate cancer is challenging because of its heterogeneity in histology, genetics and clinical outcome. The clinical outcome of patients with Gleason score 7 prostate cancer varies greatly. Improving risk assessment in this group is of particular interest, as Gleason score 7 prostate cancer on biopsy is an important clinical threshold for active treatment. Architecturally, four Gleason grade 4 growth patterns are recognized: ill-formed, fused, glomeruloid and cribriform. The aim of this review is to describe the role of cribriform growth in prostate cancer with respect to diagnosis, prognosis and molecular pathology...
February 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29593791/histopathological-characterization-and-whole-exome-sequencing-of-ectopic-thyroid-fetal-architecture-in-a-functional-ectopic-gland-from-adult-patient
#19
Rosalinda Yasato Camargo, Cristina Takami Kanamura, Celso Ubirajara Friguglietti, Célia Regina Nogueira, Sonia Iorcansky, Alfio José Tincani, Ana Karina Bezerra, Ester Brust, Fernanda Christtanini Koyama, Anamaria Aranha Camargo, Fernanda Orpinelli R Rego, Pedro Alexandre Favoretto Galante, Geraldo Medeiros-Neto, Ileana Gabriela Sanchez Rubio
Ectopic thyroid results from a migration defect of the developing gland during embryogenesis causing congenital hypothyroidism. But it has also been detected in asymptomatic individuals. This study aimed to investigate the histopathological, functional, and genetic features of human ectopic thyroids. Six samples were histologically examined, and the expression of the specific thyroid proteins was assessed by immunohistochemistry. Two samples were submitted to whole exome sequencing. An oropharynx sample showed immature fetal architecture tissue with clusters or cords of oval thyrocytes and small follicles; one sample exhibited a normal thyroid pattern while four showed colloid goiter...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29590013/response-to-comment-on-the-growth-pattern-of-neandertals-reconstructed-from-a-juvenile-skeleton-from-el-sidr%C3%A3-n-spain
#20
Antonio Rosas, Luis Ríos, Almudena Estalrrich, Helen Liversidge, Antonio García-Tabernero, Rosa Huguet, Hugo Cardoso, Markus Bastir, Carles Lalueza-Fox, Marco de la Rasilla, Christopher Dean
The comment by DeSilva challenges our suggestion that brain growth of the El Sidrón J1 Neandertal was still incomplete at 7.7 years of age. Evidence suggests that endocranial volume is likely to represent less than 90% adult size at El Sidrón as well as Neandertal male plus Krapina samples, in line with further evidence from endocranial surface histology and dural sinus groove size.
March 9, 2018: Science
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