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Takayasu disease

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https://www.readbyqxmd.com/read/28224216/vascular-surgery-the-main-risk-factor-for-mortality-in-146-takayasu-arteritis-patients
#1
Nilton Salles Rosa Neto, Samuel Katsuyuki Shinjo, Maurício Levy-Neto, Rosa Maria Rodrigues Pereira
Takayasu arteritis (TA) is an idiopathic chronic inflammatory disease that affects the aorta and its main branches. According to disease involvement, patients may require surgical treatment mainly due ischemic lesions in association with medical therapy. We evaluated the impact of vascular interventions in a cohort of TA patients. Medical records from 146 TA patients were reviewed. Clinical features, medical, and surgical treatment were revised and disease activity was determined by clinical, laboratorial, and imaging parameters...
February 21, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28210635/combined-spinal-epidural-for-vaginal-delivery-in-a-parturient-with-takayasu-s-arteritis
#2
Sean Patrick Clifford, Paul Brian Mick, Brian Matthew Derhake
Takayasu's arteritis is a rare, progressive panendarteritis involving all layers of the arterial wall. This disease includes variable involvement of the aorta and its major branches. The most common complication with this condition is severe, uncontrolled hypertension, often leading to end organ dysfunction. We describe the management of a 27-year-old woman diagnosed with Takayasu's arteritis that presented in labor with intense pain and underwent a combined spinal-epidural for anesthetic management. Per literature review, a combined spinal-epidural technique for planned vaginal delivery has not been described for a laboring Takayasu patient...
October 2016: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28188021/-vascular-lesions-in-patient-with-takayasu-arteritis-and-massive-elevated-lipoprotein-a-levels-residual-involvement-or-premature-aterosclerosis
#3
José Carlos Alarcón García, Santiago Rodríguez Suárez, Ovidio Muñiz Grijalvo, Salvador García Morillo
Lipoprotein (a) [Lp(a)] is a lipoprotein defined by presenting a specific apolipoprotein, ApoA, linked to the ApoB-100 by different types of chemical bonds, including a disulfide bridge. Despite their atherogenic mechanism is not fully understood, its importance has been demonstrated in the development of premature aterosclerosis. Multiple studies have shown its role as a cardiovascular risk factor associated with heart disease and stroke. We report the case of a patient with a diagnosis of Takayasu arteritis in which a massive elevation of Lp(a) was detected...
February 7, 2017: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/28185705/cardiovascular-magnetic-resonance-imaging-pattern-at-the-time-of-diagnosis-of-treatment-na%C3%A3-ve-patients-with-connective-tissue-diseases
#4
Sophie Mavrogeni, George Markousis-Mavrogenis, Loukia Koutsogeorgopoulou, Theodoros Dimitroulas, Konstantinos Bratis, George D Kitas, Petros Sfikakis, Maria Tektonidou, Georgia Karabela, Efthymios Stavropoulos, Gikas Katsifis, Kyriaki A Boki, Anastasia Kitsiou, Vasiliki Filaditaki, Elias Gialafos, Sotiris Plastiras, Vasiliki Vartela, Genovefa Kolovou
BACKGROUND-AIM: Cardiac involvement at diagnosis of connective tissue disease (CTD) has been described by echocardiography. We hypothesized that cardio-vascular magnetic resonance (CMR) detects occult lesions at CTD diagnosis. PATIENTS-METHODS: CMR was performed early after diagnosis in 78 treatment-naïve CTDs (aged 43±11, 59F/19M) without cardiac involvement [5 Takayasu arteritis (TA), 4 Churg Strauss syndrome (CSS), 5 Wegener granulomatosis (WG), 16 systemic lupus erythematosus (SLE), 12 rheumatoid arthritis (RA), 8 mixed connective tissue diseases (MCTD), 12 ankylosing spondylitis (AS), 3 polymyalgia rheumatica (PMR), 8 systemic sclerosis (SSc) and 5 dermatomyositis (DM)]...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28179177/advantage-of-high-b-value-diffusion-weighted-imaging-for-differentiation-of-hemangioblastoma-from-brain-metastases-in-posterior-fossa
#5
Shumpei Onishi, Takanori Hirose, Takeshi Takayasu, Ryo Nosaka, Manish Kolakshyapati, Taiichi Saito, Yuji Akiyama, Kazuhiko Sugiyama, Kaoru Kurisu, Fumiyuki Yamasaki
OBJECTIVE: It is sometimes difficult to make differential diagnosis between brain metastases and hemangioblastoma in posterior fossa. We assessed whether high b-value diffusion weighted image (DWI) at b-4000 could differentiate these tumors. METHODS: We acquired DWI at 3T magnetic resonance imaging (MRI) with b = 1000 and b = 4000 s/mm(2) in histologically confirmed 12 patients of hemangioblastoma without von-Hippel Lindau disease and 16 patients of brain metastases originating at posterior fossa...
February 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28160070/single-nucleotide-polymorphisms-of-il12b-are-associated-with-takayasu-arteritis-in-chinese-han-population
#6
Xiaoting Wen, Si Chen, Ping Li, Jing Li, Ziyan Wu, Yuan Li, Liubing Li, Hui Yuan, Xinping Tian, Fengchun Zhang, Yongzhe Li
Takayasu arteritis (TA) is a rare autoimmune disease of unknown etiology. Genome-wide association studies (GWAS) have demonstrated association between genetic variants of IL12B and IL6 and TA. Since TA has been reported with ethnic heterogeneity, we sought to investigate whether the single-nucleotide-polymorphisms (SNPs) reported in these studies are associated with TA in the Chinese Han population. A multi-center study involving 412 patients with TA and 597 healthy controls was conducted. Sequenom MassArray iPLEX platform was used to determine the frequencies of SNPs in the IL12B and IL6 region...
February 3, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28157108/the-prevalence-of-constipation-and-irritable-bowel-syndrome-in-parkinson-s-disease-patients-according-to-rome-iii-diagnostic-criteria
#7
Takayasu Mishima, Jiro Fukae, Shinsuke Fujioka, Kotoe Inoue, Yoshio Tsuboi
BACKGROUND: Gastrointestinal symptoms are one of the most common non-motor features of Parkinson's disease (PD). Recently, a report from Taiwan revealed that irritable bowel syndrome (IBS) may be associated with an increased risk of developing PD; however, the prevalence of IBS in PD patients has not been fully evaluated. Rome III criteria are widely assessed with a questionnaire to determine functional gastrointestinal disorders. OBJECTIVE: We assessed the prevalence of constipation and IBS in PD patients in our cohort using Rome III criteria...
January 30, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28157107/the-cross-sectional-area-of-paraspinal-muscles-predicts-the-efficacy-of-deep-drain-stimulation-for-camptocormia
#8
Waka Sakai, Shunya Nakane, Eiichirou Urasaki, Keisuke Toyoda, Eisaku Sadakata, Akiko Nagaishi, Takayasu Fukudome, Yuzo Yamakawa, Hidenori Matsuo
BACKGROUND: Camptocormia, a disturbance of posture, is a well-described clinical feature of PD and other parkinsonian syndromes. Previous reports have shown that DBS of the subthalamic nucleus (STN) or globus pallidus internus is effective in treating camptocormia. However, the efficacy of DBS for camptocormia varies. OBJECTIVE: To determine a clinical marker for selecting an appropriate therapy for camptocormia, a disabling manifestation of Parkinson's disease (PD) that has a variable response to systemic and local therapies...
January 30, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28116918/standard-and-biological-treatment-in-large-vessel-vasculitis-guidelines-and-current-approaches
#9
Francesco Muratore, Nicolò Pipitone, Carlo Salvarani
Giant cell arteritis and Takayasu arteritis are the two major forms of idiopathic large vessel vasculitis. High doses of glucocorticoids are effective in inducing remission in both conditions, but relapses and recurrences are common, requiring prolonged glucocorticoid treatment with the risk of the related adverse events. Areas covered: In this article, we will review the standard and biological treatment strategies in large vessel vasculitis, and we will focus on the current approaches to these diseases. Expert commentary: The results of treatment trials with conventional immunosuppressive agents such as methotrexate, azathioprine, mycophenolate mofetil, and cyclophosphamide have overall been disappointing...
February 6, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28109928/fdg-uptake-by-prosthetic-arterial-grafts-in-large-vessel-vasculitis-is-not%C3%A2-specific-for-active-disease
#10
Taryn Youngstein, Enrico Tombetti, Jaita Mukherjee, Tara D Barwick, Adil Al-Nahhas, Emyr Humphreys, Julian Nash, Jacqueline Andrews, Elena Incerti, Elisabetta Tombolini, Annalaura Salerno, Silvia Sartorelli, Giuseppe A Ramirez, Maurizio Papa, Maria Grazia Sabbadini, Luigi Gianolli, Francesco De Cobelli, Federico Fallanca, Elena Baldissera, Angelo A Manfredi, Maria Picchio, Justin C Mason
OBJECTIVES: This study investigated the incidence and clinical significance of arterial graft-associated uptake of fluorodeoxyglucose in large-vessel vasculitis (LVV). BACKGROUND: The role of (18)F-labeled fluorodeoxyglucose-positron emission tomography/computed tomography ([(18)F]FDG-PET/CT) in the management of LVV remains to be defined. Although [(18)F]FDG uptake at arterial graft sites raises concerns regarding active arteritis or infection, its clinical significance in LVV has never been formally studied...
January 11, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28106684/sudden-death-due-to-unusual-complication-of-takayasu-arteritis-an-autopsy-case
#11
Maher Jedidi, Youssef Chkirbene, Nihed Abdessayed, Tasnim Masmoudi, Mohamed Mahjoub, Souheil Mlayeh, Mohamed Ben Dhiab, Mohamed Kamel Souguir, Mohamed Taher Yacoubi
Takayasu arteritis is an uncommon inflammatory disease with usually a good prognosis. However, sometimes, the evolution can be fatal essentially by a coronary arteries involvement. We present a case of a 19-year-old woman who died suddenly from cardiogenic shock complicating an unknown Takayasu arteritis.At the autopsy, the aorta showed a significant thickening of the wall. The coronary arteries were slightly thickened and did not show any occlusion. Microscopic examination of the aorta showed an abundant granulomatous and a lymphoplasmacytic infiltrate...
January 18, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28105135/takayasu-s-arteritis-presenting-with-common-carotid-artery-dissection-a-rare-case-report
#12
Ruonan Hao, Jie Zhang, Zhicheng Ma, Ming Xiao, Lei Zhou, Nan Kang, Xiaoyu Liang, Fuxin Li
Takayasu's arteritis (TA) is a rare, idiopathic, chronic inflammatory disease associated with cell-mediated inflammation and involving predominantly the aorta and its primary branches. TA results in stenosis, occlusion or aneurysmal degeneration of large arteries pathologically. However, the incidence of dissection in arteries is low. As one of the primary causes of aortic dissection-associated ischemic stroke in young adults, only a limited number of TA cases presenting with aortic dissection have been published to date...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28101023/pyoderma-gangrenosum-and-erythema-nodosum-revealing-takayasu-s-arteritis
#13
Jonas Loetscher, Susanna Fistarol, Ulrich A Walker
We report a Caucasian female who presented with simultaneous erythema nodosum and pyoderma gangrenosum due to underlying Takayasu's arteritis. Takayasu's arteritis is a chronic large vessel vasculitis of unknown cause. The disease has a worldwide distribution but is most commonly seen in Asian populations. There is a strong predilection for young females. The clinical presentation is variable, but mostly derives from stenosis or occlusion of affected arteries, resulting in claudication and ischemia. Skin manifestations are observed in up to 28% of patients with Takayasu's arteritis, with erythema nodosum reported more frequently in Caucasians...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28098123/typhoid-associated-acute-kidney-injury-masquerading-as-a-relapse-of-takayasu-arteritis
#14
Revanasiddappa Manjunath, Anupama Kaul, Raj Kumar Sharma, Dharmendra Singh Bhadauria, Narayan Prasad, Amit Gupta
Renal dysfunction is common in Takayasu arteritis. Uncommonly, renal failure in a case of Takayasu arteritis can be due to an unrelated disease, and if the disease is a rare complication, it is even more difficult to diagnose. We report a 21-year-old male with type IV Takayasu arteritis presenting with fever and renal failure, who was diagnosed to have enteric fever- related glomerulonephritis which was successfully treated.
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28067080/-recent-advances-in-the-treatment-of-large-vessel-vasculitides
#15
Melinda Zsuzsanna Szabó, Emese Kiss
Giant cell arteritis and Takayasu arteritis classified to large vessel vasculitides have similar histopathology in the vascular wall proposing that these entities can be different phenotypes on a spectrum of a single disorder. Glucocorticoids are the mainstay of therapy combined with cyclophosphamide, azatioprine and mycofenolate mofetil, when it is required. However, a significant proportion of patients are glucocorticoid-dependent despite of the conventional disease-modifying antirheumatic drugs and suffer from serious side effects of the steroids, therefore alternate options for more effective disease management are needed...
January 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28064210/characteristics-of-autoantibodies-targeting-14-3-3-proteins-and-their-association-with-clinical-features-in-newly-diagnosed-giant-cell-arteritis
#16
Anne Kistner, Marc B Bigler, Kathrin Glatz, Simon B Egli, Fabian S Baldin, Florian A Marquardsen, Matthias Mehling, Katharina M Rentsch, Daniel Staub, Markus Aschwanden, Mike Recher, Thomas Daikeler, Christoph T Berger
OBJECTIVES: Autoantibodies are useful biomarkers for diagnosing and monitoring treatment in some autoimmune diseases. Antibodies against isoforms of 14-3-3 protein have been proposed as biomarkers for the presence of aortic aneurysm in large-vessel vasculitis (LVV). Here, we aimed to evaluate the diagnostic role and potential immunopathological involvement of anti-14-3-3 antibodies in newly diagnosed LVV patients. METHODS: Antibodies against three isoforms of 14-3-3 (γ, ε and ζ) were measured in 90 subjects: 48 GCA and 3 Takayasu's arteritis (TA) patients, and 39 controls (non-inflammatory and inflammatory diseases), using a multiplexed bead-based immunoassay and immunoprecipitation studies...
January 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28052936/klhl3-knockout-mice-reveal-the-physiological-role-of-klhl3-and-the-pathophysiology-of-phaii-caused-by-mutant-klhl3
#17
Emi Sasaki, Koichiro Susa, Takayasu Mori, Kiyoshi Isobe, Yuya Araki, Yuichi Inoue, Yuki Yoshizaki, Fumiaki Ando, Yutaro Mori, Shintaro Mandai, Moko Zeniya, Daiei Takahashi, Naohiro Nomura, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara
Mutations in the with-no-lysine kinase 1 (WNK1), WNK4, kelch-like 3 (KLHL3), and cullin3 (CUL3) genes are known to cause the hereditary disease pseudohypoaldosteronism type II (PHAII). It was recently demonstrated that this results from the defective degradation of WNK1 and WNK4 by the KLHL3/CUL3 ubiquitin ligase complex. However, the other physiological in vivo roles of KLHL3 remain unclear. Therefore, here we generated KLHL3(-/-) mice that expressed β-galactosidase (β-gal) under the endogenous KLHL3 promoter...
January 4, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28031639/takayasu-arteritis-with-multiple-coronary-artery-fistulas-to-bronchial-arteries
#18
Kanber Ocal Karabay, Emine Altuntas, Ender Uysal, Ahmet Ozkara, Vedat Aytekin
Takayasu arteritis (TA) is an inflammatory disease that commonly occurs in young females. Coronary involvement occurs rarely and mostly with stenosis. Here, we present a case of TA associated with fistulas between the coronary arteries and the bronchial arteries.
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28018468/posterior-reversible-encephalopathy-syndrome-caused-by-presumed-takayasu-arteritis
#19
Ki Wuk Lee, Sang Taek Lee, Heeyeon Cho
Takayasu arteritis (TA) is a chronic inflammatory disease of unknown etiology that affects mainly the aorta, main aortic branches, and pulmonary arteries. Diverse neurological manifestations of TA have rarely been reported in children. Posterior reversible encephalopathy syndrome (PRES) is a neuroradiological condition that presents with headache, seizure, visual disturbances, and characteristic lesions on imaging. Inflammatory condition and severe hypertension in TA can cause PRES. We report of a 5-year-old girl with presumed TA who presented with PRES and chronic total occlusion in the renal artery...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28011738/coronary-artery-and-supra-aortic-vessel-revascularization-without-aortic-clamping-for-takayasu-arteritis
#20
Hiroaki Osada, Naoki Kanemitsu, Kaori Kato, Kazuo Yamanaka
Takayasu arteritis (TA) is a rare idiopathic large-vessel vasculitis involving the aorta and its major branches. Coronary artery disease and its surgical management in patients with TA is also a rare clinical entity. We report the case of a 73-year-old woman with TA and 3-vessel coronary artery disease in whom we performed off-pump coronary artery bypass graft concomitant with supra-aortic vessel revascularization.
December 22, 2016: Interactive Cardiovascular and Thoracic Surgery
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