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Takayasu disease

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https://www.readbyqxmd.com/read/28067080/-recent-advances-in-the-treatment-of-large-vessel-vasculitides
#1
Melinda Zsuzsanna Szabó, Emese Kiss
Giant cell arteritis and Takayasu arteritis classified to large vessel vasculitides have similar histopathology in the vascular wall proposing that these entities can be different phenotypes on a spectrum of a single disorder. Glucocorticoids are the mainstay of therapy combined with cyclophosphamide, azatioprine and mycofenolate mofetil, when it is required. However, a significant proportion of patients are glucocorticoid-dependent despite of the conventional disease-modifying antirheumatic drugs and suffer from serious side effects of the steroids, therefore alternate options for more effective disease management are needed...
January 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28064210/characteristics-of-autoantibodies-targeting-14-3-3-proteins-and-their-association-with-clinical-features-in-newly-diagnosed-giant-cell-arteritis
#2
Anne Kistner, Marc B Bigler, Kathrin Glatz, Simon B Egli, Fabian S Baldin, Florian A Marquardsen, Matthias Mehling, Katharina M Rentsch, Daniel Staub, Markus Aschwanden, Mike Recher, Thomas Daikeler, Christoph T Berger
OBJECTIVES: Autoantibodies are useful biomarkers for diagnosing and monitoring treatment in some autoimmune diseases. Antibodies against isoforms of 14-3-3 protein have been proposed as biomarkers for the presence of aortic aneurysm in large-vessel vasculitis (LVV). Here, we aimed to evaluate the diagnostic role and potential immunopathological involvement of anti-14-3-3 antibodies in newly diagnosed LVV patients. METHODS: Antibodies against three isoforms of 14-3-3 (γ, ε and ζ) were measured in 90 subjects: 48 GCA and 3 Takayasu's arteritis (TA) patients, and 39 controls (non-inflammatory and inflammatory diseases), using a multiplexed bead-based immunoassay and immunoprecipitation studies...
January 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28052936/klhl3-knockout-mice-reveal-the-physiological-role-of-klhl3-and-the-pathophysiology-of-phaii-caused-by-mutant-klhl3
#3
Emi Sasaki, Koichiro Susa, Takayasu Mori, Kiyoshi Isobe, Yuya Araki, Yuichi Inoue, Yuki Yoshizaki, Fumiaki Ando, Yutaro Mori, Shintaro Mandai, Moko Zeniya, Daiei Takahashi, Naohiro Nomura, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara
Mutations in the with-no-lysine kinase 1 (WNK1), WNK4, kelch-like 3 (KLHL3), and cullin3 (CUL3) genes are known to cause the hereditary disease pseudohypoaldosteronism type II (PHAII). It was recently demonstrated that this results from the defective degradation of WNK1 and WNK4 by the KLHL3/CUL3 ubiquitin ligase complex. However, the other physiological in vivo roles of KLHL3 remain unclear. Therefore, here we generated KLHL3(-/-) mice that expressed β-galactosidase (β-gal) under the endogenous KLHL3 promoter...
January 4, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28031639/takayasu-arteritis-with-multiple-coronary-artery-fistulas-to-bronchial-arteries
#4
Kanber Ocal Karabay, Emine Altuntas, Ender Uysal, Ahmet Ozkara, Vedat Aytekin
Takayasu arteritis (TA) is an inflammatory disease that commonly occurs in young females. Coronary involvement occurs rarely and mostly with stenosis. Here, we present a case of TA associated with fistulas between the coronary arteries and the bronchial arteries.
December 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28018468/posterior-reversible-encephalopathy-syndrome-caused-by-presumed-takayasu-arteritis
#5
Ki Wuk Lee, Sang Taek Lee, Heeyeon Cho
Takayasu arteritis (TA) is a chronic inflammatory disease of unknown etiology that affects mainly the aorta, main aortic branches, and pulmonary arteries. Diverse neurological manifestations of TA have rarely been reported in children. Posterior reversible encephalopathy syndrome (PRES) is a neuroradiological condition that presents with headache, seizure, visual disturbances, and characteristic lesions on imaging. Inflammatory condition and severe hypertension in TA can cause PRES. We report of a 5-year-old girl with presumed TA who presented with PRES and chronic total occlusion in the renal artery...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28011738/coronary-artery-and-supra-aortic-vessel-revascularization-without-aortic-clamping-for-takayasu-arteritis
#6
Hiroaki Osada, Naoki Kanemitsu, Kaori Kato, Kazuo Yamanaka
Takayasu arteritis (TA) is a rare idiopathic large-vessel vasculitis involving the aorta and its major branches. Coronary artery disease and its surgical management in patients with TA is also a rare clinical entity. We report the case of a 73-year-old woman with TA and 3-vessel coronary artery disease in whom we performed off-pump coronary artery bypass graft concomitant with supra-aortic vessel revascularization.
December 22, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28010147/adaptive-optics-imaging-in-retinal-vasculitis
#7
Padmamalini Mahendradas, Ruchi Vala, Ankush Kawali, Mukund C Akkali, Rohit Shetty
PURPOSE: To study the sheathing of retinal vasculitis in various systemic autoimmune diseases using adaptive optics imaging (AOI). METHODS: Prospective, observational case series with six patients: Behçet disease (n = 1); systemic lupus erythematosus (n = 1); idiopathic retinal vasculitis (n = 2); granulomatosis with polyangiitis (n = 1); and Takayasu aorta arteritis (n = 1). Fundus photograph (FP), fundus fluorescein angiography (FFA) were done in all cases at presentation...
December 23, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27994990/refractory-case-of-takayasu-arteritis-in-a-young-woman-a-clinical-challenge
#8
Mudassar Ahmed, Salman Mansoor, Salman Assad, Shahar Y Khan, Rizwanullah Khan, Usman Ghani, Taimur Mansoor, Aasim Rehman
Takayasu arteritis (TA) is an idiopathic chronic inflammatory vasculitis of the aorta and its main branches, which if not treated can lead to severe vascular damage and fatal vascular events. Glucocorticoids (GCs) are the mainstay of the therapy of TA but a significant proportion of patients tend to experience flare-ups when their GCs are tapered. We report a case of a 42-year-old female with TA, diagnosed according to the 1990 American College of Rheumatology Criteria for TA. Cardiovascular assessment showed normal carotid upstrokes with bilateral carotid bruits and soft right and left subclavian bruits with weak peripheral pulses...
November 9, 2016: Curēus
https://www.readbyqxmd.com/read/27989502/profiles-of-serum-cytokine-levels-in-takayasu-arteritis-patients-potential-utility-as-biomarkers-for-monitoring-disease-activity
#9
Natsuko Tamura, Yasuhiro Maejima, Daisuke Tezuka, Chisato Takamura, Shunji Yoshikawa, Takashi Ashikaga, Kenzo Hirao, Mitsuaki Isobe
BACKGROUND: Takayasu arteritis (TA) is an autoimmune arteritis of unknown etiology. Currently, the erythrocyte sedimentation rate (ESR) and serum C-reactive protein (CRP) levels are widely used to monitor disease activity of TA. However, sometimes it is difficult to reflect inflammatory symptoms in either CRP or ESR values, especially in TA patients with immunosuppressive therapies. Therefore, higher-accuracy biomarkers for evaluating disease activity need to be explored. METHODS AND RESULTS: We examined 21 Japanese patients diagnosed with TA; 17 TA patients were treated with prednisone with or without additional immunosuppressive therapies and the remaining 4 patients were treated with infliximab, a human monoclonal anti-tumor necrosis factor (TNF)-α antibody...
December 15, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27988436/a-scoping-review-of-the-use-of-non-biologic-disease-modifying-anti-rheumatic-drugs-in-the-management-of-large-vessel-vasculitis
#10
REVIEW
Durga Prasanna Misra, Aman Sharma, Tamilarasu Kadhiravan, Vir Singh Negi
Takayasu's arteritis (TA) and Giant cell arteritis (GCA) comprise the large vessel vasculitides (LVV). Patients with LVV are treated with disease-modifying anti-rheumatic drugs (DMARDs), both conventional (cDMARDs) and biologic (bDMARDs). We undertook a scoping review to assess the effectiveness of cDMARDs in TA and GCA. We could identify 11 studies in TA and 18 studies in GCA. There were only 3 randomized controlled trials on methotrexate, one on hydroxychloroquine and two on cyclosporine in GCA, the others being case series (including all studies on TA)...
December 15, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27978898/-risk-factors-for-long-term-result-of-endovascular-treatment-for-auto-immune-disease-related-abdominal-aorta-pseudo-aneurysm
#11
W Ye, X Di, Q Liu, Y J Li, Y H Zheng, R Zeng, X J Song, Z L Liu, C W Liu
Objective: To summarize results of endovascular treatment for auto-immune disease related abdominal aorta pseudo-aneurysm(AIPA), and to analysis clinical predictors of long term major adverse clinical events(MACE). Methods: Retrospectively collected endovascular treatment for AIPA cases in Peking Union Medical College Hospital within 2000 to 2015. Twenty-nine cases with AIPA treated by endovascular therapy were enrolled in this study. Twenty five cases were male, range from 23 to 67 years old, mean age was (39...
December 6, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27965905/stroke-as-the-sole-manifestation-of-takayasu-arteritis-in-a-15-year-old-boy-with-latent-tuberculosis
#12
Espen Benjaminsen, Anne Reigstad, Vanja Cengija, Vibke Lilleby, Maria Carlsson
Introduction. Takayasu arteritis is a rare disease affecting the aorta and its main branches, causing arterial claudication and end-organ ischemia, including stroke. The etiology is unknown but is believed to be autoimmune. An association between Takayasu arteritis and tuberculosis has been suggested, but the possible relation is unclear. Case Presentation. A 15-year-old Somali boy was diagnosed with latent tuberculosis. He had a lesion in the right lung, and both the tuberculin skin test by the Mantoux method and Quantiferon GOLD test turned out positive...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27957366/severe-corticosteroid-induced-ocular-hypertension-requiring-bilateral-trabeculectomies-in-a-patient-with-takayasu-s-arteritis
#13
Anna Maria Gruener, Pranev Sharma, Sally Ameen, Faisal Ahmed
We present a rare case of severe corticosteroid-induced ocular hypertension (OHT) after prolonged systemic corticosteroid use in a young woman with Takayasu's arteritis. As she did not sufficiently respond to ocular antihypertensive therapies, bilateral enhanced trabeculectomies were required to normalize her intraocular pressures. The systemic side effects of corticosteroids are well known, yet steroid-induced OHT and glaucoma remain silent causes of ocular morbidity. This case highlights the importance of IOP-monitoring in visually asymptomatic patients on systemic corticosteroids...
2016: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/27935894/-outcomes-of-surgical-management-of-patients-with-nonspecific-aortoarteritis-with-isolated-lesion-of-brachiocephalic-arteries
#14
F Sh Bakhritdinov, A S Suyumov, N U Sharapov
The authors analysed herein the results of examination and surgical treatment of patients presenting with Takayasu aortoarteritis with an isolated lesion of the aortic arch branches. Discrepancy between the degree of ischaemia, dissemination, and localization of lesions, as well as ambiguity of neurological manifestations suggests large compensatory possibilities of the cerebral circulation in this disease. The revealed peculiarities of lesions of the brachiocephalic arteries characteristic the pathology concerned were as follows: high incidence of lesions of subclavian arteries (mainly in the second and third segments), utterly rare involvement of the brachiocephalic trunk, a stenosisng pattern of lesion of carotid arteries with predominant localization in the common carotid artery, not involving it into the process of bifurcation...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27924855/the-efficacy-of-mycophenolate-mofetil-for-the-treatment-of-chinese-takayasu-s-arteritis
#15
Jing Li, Yunjiao Yang, Jiuliang Zhao, Mengtao Li, Xinping Tian, Xiaofeng Zeng
To investigate the therapeutic effect of mycophenolate mofetil(MMF) on Chinese Takayasu's arteritis(TAK) patients. Thirty consecutive TAK outpatients were prospectively enrolled during 2013 to 2015. MMF combined with glucocorticoid was the primary treatment regimen. If clinical stable disease could not be reached, another traditional immunosuppressive agent could be added. All patients were evaluated and followed up every 3 months and vascular image studies by Doppler ultrasonography were repeated every 6 months...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27908308/remarkable-damage-along-with-poor-quality-of-life-in-takayasu-arteritis-cross-sectional-results-of-a-long-term-followed-up-multicentre-cohort
#16
Ahmet Omma, Burak Erer, Omer Karadag, Neslihan Yilmaz, Fatma Alibaz-Oner, Fatih Yildiz, Melike Kalfa, Gezmis Kimyon, Sedat Kiraz, Haner Direskeneli, Eren Erken, Kenan Aksu, Ahmet Mesut Onat, Ahmet Gül, Lale Ocal, Murat Inanc, Sevil Kamali
OBJECTIVES: We aimed to assess the outcome of a large Takayasu arteritis (TAK) cohort using the vasculitis damage index (VDI) and quality of life (QoL) scale, tools which have been validated for vasculitis. METHODS: Disease activity, damage and QoL were cross-sectionally evaluated in 165 TAK patients from 6 centres. SF-36 were applied to 51 age-matched healthy controls (HC). Persistent activity for ≥6 months was considered as treatment resistance (r-TAK). The correlation between VDI, clinical characteristics and mental (MCS)/physical (PCS) component scores of SF-36 were analysed...
November 10, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27903831/dietary-mung-bean-protein-reduces-hepatic-steatosis-fibrosis-and-inflammation-in-male-mice-with-diet-induced-nonalcoholic-fatty-liver-disease
#17
Hitoshi Watanabe, Yuka Inaba, Kumi Kimura, Shun-Ichiro Asahara, Yoshiaki Kido, Michihiro Matsumoto, Takayasu Motoyama, Nobuhiko Tachibana, Shuichi Kaneko, Mitsutaka Kohno, Hiroshi Inoue
BACKGROUND: As the prevalence of nonalcoholic fatty liver disease (NAFLD), including steatosis and nonalcoholic steatohepatitis, is increasing, novel dietary approaches are required for the prevention and treatment of NAFLD. OBJECTIVE: We evaluated the potential of mung bean protein isolate (MuPI) to prevent NAFLD progression. METHODS: In Expts. 1 and 2, the hepatic triglyceride (TG) concentration was compared between 8-wk-old male mice fed a high-fat diet (61% of energy from fat) containing casein, MuPI, and soy protein isolate and an MuPI-constituent amino acid mixture as a source of amino acids (18% of energy) for 4 wk...
November 30, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27867673/central-retinal-artery-occlusion-in-takayasu-s-arteritis-as-the-first-presentation-of-the-disease
#18
Hande Guclu, Vuslat Pelitli Gurlu, Sadık Altan Ozal, Orkut Guclu
Takayasu's arteritis (TA) is a chronic inflammatory granulomatous vasculitis which affects large and medium arterial vessels. The disease involves especially subclavian arteries and aortic branches but it can consist of any arteries. The major pathology is granulomatous panarteritis with intima proliferation and defects of the elastic lamina of the vessels. We present a case of central retinal artery occlusion in TA as the first presentation of the disease. To the best of our knowledge, the present case is the first case that demonstrates central retinal artery occlusion as an initial manifestation in TA...
2016: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/27817935/takayasu-arteritis-masquerading-as-stable-angina-in-a-29-year-old-man
#19
Lei Wang, Teng Ma, Yun-Tao Zhao
Takayasu arteritis is a form of vasculitis that involves the aorta, its major branches, and the pulmonary arteries. Coronary artery involvement is not uncommon, and most frequently includes the ostia and proximal segments. Early diagnosis of Takayasu arteritis is difficult since it is a rare disease and is accompanied by various nonspecific clinical symptoms. However, recent advances in imaging modalities-including magnetic resonance angiography, computed tomography (CT), sonography, and fluoro-deoxyglucose positron emission tomography (FDG-PET)/CT Isobe (2013) [2]-have facilitated earlier and more accurate diagnoses of this condition...
October 29, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27814989/a-curious-case-of-septic-shock
#20
Arjun Lakshman, Charanpreet Singh, Manphool Singhal, Sanjay Jain, Navneet Sharma, Savita Kumari, Subhash Varma
BACKGROUND: Takayasu arteritis, also known as "pulseless disease," causes proximal occlusion of the lumen of large arteries of the neck and arm, leading to impalpable pulses and "pseudohypotension." This may misdirect the management plan for a patient in the emergency setting if the presence of vascular occlusion is not previously known. CASE REPORT: We describe a young woman who presented to the emergency department (ED) with fever. On evaluation, she had shock, which was not responsive to a fluid bolus...
November 1, 2016: Journal of Emergency Medicine
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