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Pelvic organ prolapse

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https://www.readbyqxmd.com/read/29241922/single-incision-anterior-apical-mesh-and-sacrospinous-ligament-fixation-in-pelvic-prolapse-surgery-at-36-months-follow-up
#1
Tsia-Shu Lo, Ahlam Mahmoud Al-Kharabsheh, Yiap Loong Tan, Leng Boi Pue, Wu-Chiao Hsieh, Ma Clarissa Uy-Patrimonio
OBJECTIVE: To compare the clinical efficacy, recurrence, complications and quality of life changes 3 years after Elevate-A/single incision mesh surgery anterior apical (SIM A) and sacrospinous ligament fixation (SSF) in the management of pelvic organ prolapse (POP). MATERIALS AND METHODS: A prospective cohort study, 139 women, underwent transvaginal surgery for anterior and/or apical POP > stage 2, 69 patients had SIM A and 70 patients had SSF. The objective cure was defined as POP ≤ stage 1 anterior, apical according to POP-Q...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29241914/estrogen-receptor-and-laminin-genetic-polymorphism-among-women-with-pelvic-organ-prolapse
#2
Bothaina Nakad, Fuad Fares, Naiel Azzam, Benjamin Feiner, Ariel Zilberlicht, Yoram Abramov
OBJECTIVE: Laminin is a connective tissue component. The LAMC1 gene encodes for gamma-1 chain of laminin, which is associated with familial clustering of POP. The ERα gene which encodes for cellular estrogen receptor has also been associated with POP. The aim of this study was to evaluate a possible correlation between polymorphism in these genes and the risk for developing POP. MATERIALS AND METHODS: Blood samples were drawn from 33 women with advanced POP (study group) and 33 women without POP (control group)...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29237928/correlations-between-mitofusin-2-expression-in-fibroblasts-and-pelvic-organ-prolapse-an-in-vitro-study
#3
Ye Lu, Hua-Yun Chen, Xiao-Qing Wang, Jing-Xue Wang
BACKGROUND: Both Mitofusin 2 (Mfn2) and pelvic organ prolapse (POP) are related to aging. The aim of the present study was to investigate the variations of Mfn2 expression in the uterosacral ligaments of patients with and/or without POP and their correlations with the expression of procollagen. METHODS: Fibroblasts were cultured using tissue specimens that were harvested from the uterosacral ligaments of POP and non-POP (NPOP) patients (n = 10 for each group) from September 2016 to December 2016...
December 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29233247/pelvic-organ-prolapse-in-a-fighter-pilot-with-alpha-1-antitrypsin-deficiency
#4
Kerry Buckley, Jami Gann, Heather Barbier, Joy Greer
BACKGROUND: Few researchers have studied symptomatic younger to middle-aged women with pelvic organ prolapse. The association between highly strenuous activity and prolapse symptoms is largely theoretical. It is also known that a genetic component likely contributes to early-onset pelvic organ prolapse, but prevention and treatment with respect to this has not been explored. Service restrictions differ for active duty women who are diagnosed with symptomatic pelvic organ prolapse. CASE REPORT: We present a case of a 33-yr-old Gravida 1 Para 1 fighter pilot who developed symptomatic pelvic organ prolapse after a vaginal delivery...
January 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29232268/pelvic-organ-prolapse-repair-using-the-uphold-vaginal-support-system-5-year-follow-up
#5
Päivi Rahkola-Soisalo, Tomi S Mikkola, Daniel Altman, Christian Falconer
OBJECTIVE: This study aimed to assess the long-term (5 years) outcomes of the Uphold Vaginal Support System for symptomatic vaginal apical prolapse with or without anterior colporraphy. METHODS: In total, 164 (81.2%) of 202 women operated on in 24 centers were reached for follow-up. Outcomes were assessed by using the Pelvic Organ Prolapse Quantification, the Pelvic Floor Distress Inventory 20, and the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire questionnaires...
December 11, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29232267/concomitant-anterior-repair-preoperative-prolapse-severity-and-anatomic-prolapse-outcomes-after-vaginal-apical-procedures
#6
Charles W Nager, Cara L Grimes, Tracy L Nolen, Clifford Y Wai, Linda Brubaker, Peter C Jeppson, Tracey S Wilson, Anthony G Visco, Matthew D Barber, Gary Sutkin, Peggy Norton, Charles R Rardin, Lily Arya, Dennis Wallace, Susan F Meikle
OBJECTIVE: The aim of the study was to compare anterior and overall prolapse prevalence at 1 year in surgical participants with or without concomitant anterior repair (AR) at the time of sacrospinous ligament fixation (SSLF) or uterosacral ligament suspension (ULS). METHODS: This is a secondary analysis of two surgical trials; concomitant AR was performed at surgeon's discretion. Anterior anatomic success was defined as pelvic organ prolapse quantification of prolapse point Ba ≤0 and overall success was defined as pelvic organ prolapse quantification points Ba, Bp, and C ≤0 at 12 months...
December 11, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29230415/hypoxia-induces-apoptosis-through-hif-1%C3%AE-signaling-pathway-in-human-uterosacral-ligaments-of-pelvic-organ-prolapse
#7
Xinrui Zhao, Congcong Ma, Rui Li, Jing Xue, Lidong Liu, Peishu Liu
The purpose of this study is to evaluate the expression of hypoxia-inducible factor-1α (HIF-1α) in women uterosacral ligament tissues with pelvic organ prolapse and women with normal uterine support structures and illuminate its relationship with apoptosis. Samples were collected from 38 women with pelvic organ prolapse and 31 age matched controls. The expression levels of HIF-1α and BNIP3 in the uterosacral ligaments were measured using immunohistochemistry, qRT-PCR, and Western blot. To assess apoptosis we performed TUNEL assay and Western blot analyses...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29217925/prevalence-and-factors-associated-with-pelvic-organ-prolapse-among-pedestrian-back-loading-women-in-bench-maji-zone
#8
Andualem Henok
Background: It is common to see women carrying heavy loads on their back in developing countries including Ethiopia. This may have an effect on pelvic organ prolapse. The objective of this study was to determine prevalence and factors associated with pelvic organ prolapse among pedestrian back-loading women in Bench-MajiZone, 2016. Methods: The study was conducted in Bench-MajiZone, Southwest Ethiopia, from January to March 2016. Cross-sectional study design was employed...
May 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29214325/anterior-colporrhaphy-a-standard-operation-systematic-review-of-the-technical-aspects-of-a-common-procedure-in-randomized-controlled-trials
#9
REVIEW
Ksenia Halpern-Elenskaia, Wolfgang Umek, Barbara Bodner-Adler, Engelbert Hanzal
INTRODUCTION: Anterior colporrhaphy (AC) is considered a standard procedure and is performed all over the world. However, not a single step of the procedure has ever been truly standardized and the rates of failure show a wide range in the literature from 0% up to 92%. The aim of this systematic review was to evaluate the differences in technique and procedure worldwide. METHODS: We performed a systematic literature search up to March 2016 using the MeSH terms "(anterior AND (colporrhaph* or colporhaph* or repair* or cystocel*)" using Preferred Reporting Items for Sytematic Reviews and Meta-Analyses (PRISMA)...
December 6, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/29212782/trials-of-transvaginal-mesh-devices-for-pelvic-organ-prolapse-a-systematic-database-review-of-the-us-fda-approval-process
#10
Carl J Heneghan, Ben Goldacre, Igho Onakpoya, Jeffrey K Aronson, Tom Jefferson, Annette Pluddemann, Kamal R Mahtani
INTRODUCTION: Transvaginal mesh devices are approved in the USA by the Food and Drug Administration (FDA), through the 510(k) system. However, there is uncertainty about the benefit to harm balance of mesh approved for pelvic organ prolapse. We, therefore, assessed the evidence at the time of approval for transvaginal mesh products and the impact of safety studies the FDA mandated in 2012 because of emerging harms. METHODS: We used FDA databases to determine the evidence for approval of transvaginal mesh...
December 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/29207889/primary-carcinosarcoma-of-the-vagina-associated-with-differentiated-squamous-intraepithelial-neoplasia-in-a-patient-with-complete-uterine-prolapse-case-report-and-review-of-the-literature
#11
Emina Babarović, Karla Sladoljev, Ena Perin, Marko Klarić, Ružica Karnjuš-Begonja, Tamara Sinožić, Morana Dinter, Lana Glavan Gačanin, Senija Eminović
Vaginal carcinosarcomas (VCSs) are rare and clinically aggressive neoplasms. Primary vaginal malignancies are among the rarest malignant tumors, so clear management guidelines and optimal therapy, especially in the presence of significant pelvic organ prolapse, has not been determined. Here, we present a case of primary VCS closely associated with differentiated squamous intraepithelial neoplasia (DSIN), from which it appeared to have arisen in a postmenopausal patient with complete uterine prolapse. The unusual presentation of our case with DSIN in the adjacent vaginal epithelium with possible diagnostic pitfalls emphasizes the need for systemic presentation of these cases to help pathologists and clinicians know that such lesions can initially present in a patient with complete uterine prolapse...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29207080/effect-of-puerarin-on-collagen-metabolism-of-fibroblasts-in-pelvic-tissue-of-women-with-pelvic-organ-prolapse
#12
Yang Li, Li Hong, Cheng Liu, Jie Min, Shasha Hong, Ming Hu, Yang Zhao, Qing Yang, Jianming Tang, Songming He
The aim of the present study was to investigate the protective effect of puerarin on pelvic organ prolapse (POP) and the underlying mechanisms that regulate the metabolism of human parametrial ligament fibroblasts (HPLFs). HPLFs obtained from the pelvic tissue of patients with (n=10) or without (n=8) POP during hysterectomy were isolated by enzymatic digestion and subsequently identified by immunocytochemistry in a previous study of the authors. Following this, cultured HPLFs were treated with 0.01, 0.10 or 1...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29198547/pelvic-organ-prolapse
#13
EDITORIAL
Huann-Cheng Horng, Fa-Kung Lee, Peng-Hui Wang
No abstract text is available yet for this article.
November 30, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29189386/postoperative-voiding-dysfunction-the-preferred-method-for-catheterization
#14
Colleen D McDermott, Victoria Ryan, Ariel Pulver, Marianne Boutet
OBJECTIVES: Bladder drainage can be achieved by clean intermittent self-catheterization (CISC), transurethral indwelling catheterization (TIC), or with a suprapubic tube (SPT). The primary objective of this study was to determine patient preference for catheter type in the management of potential voiding dysfunction after pelvic organ prolapse (POP) surgery. METHODS: Between 2012 and 2016, patients scheduled for POP surgery were recruited into the study. Before surgery, patients were informed of the potential for postoperative voiding dysfunction and the catheter choices were discussed...
November 17, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29184855/dealing-with-complex-overactive-bladder-syndrome-patient-profiles-with-focus-on-fesoterodine-in-or-out-of-the-eau-guidelines
#15
REVIEW
John Heesakkers, Montserrat Espuña Pons, Philip Toozs Hobson, Emmanuel Chartier-Kastler
Overactive bladder (OAB) syndrome is a common, complex, and challenging condition. To assist the management of these patients, the European Association of Urology (EAU) updates its guidelines annually. This review reports the presentations from the symposium titled "Dealing with complex OAB patient profiles: in or out of the EAU guidelines?" held at the 32nd EAU Annual Congress in March 2017 in London. The symposium focused on three groups of OAB patients: women who may also suffer pelvic organ prolapse, stress urinary incontinence, the genitourinary syndrome of menopause (GSM); patients at risk of cognitive impairment; and elderly patients...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/29175132/dutch-women-s-attitudes-towards-hysterectomy-and-uterus-preservation-in-surgical-treatment-of-pelvic-organ-prolapse
#16
Mèlanie N van IJsselmuiden, Renée J Detollenaere, Maaike B E Gerritse, Kirsten B Kluivers, Marlies Y Bongers, Hugo W F van Eijndhoven
OBJECTIVE: To investigate Dutch women's attitudes and preferences towards hysterectomy or uterus preservation in surgical treatment of pelvic organ prolapse. STUDY DESIGN: Women's attitude was assessed by a structured questionnaire in one university hospital and one non-university teaching hospital in the Netherlands. Between December 2013 and November 2014, 102 women referred with prolapse complaints, without previous prolapse surgery, responded to the questionnaire received by mail prior to gynaecological consultation...
November 21, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29175131/sacrocolpopexy-with-polyvinylidene-fluoride-mesh-for-pelvic-organ-prolapse-mid-term-comparative-outcomes-with-polypropylene-mesh
#17
Raffaele Balsamo, Ester Illiano, Alessandro Zucchi, Franca Natale, Antonio Carbone, Marco De Sio, Elisabetta Costantini
OBJECTIVE: The aim of this study was to compare the surgical, anatomical, and functional outcomes of sacrocolpopexy (SCP) using polyvinylidene fluoride (PVDF) mesh versus SCP using the standard polypropylene (PP) mesh. STUDY DESIGN: This was a retrospective single centre case-control study including female patients who underwent laparoscopic or abdominal SCP for POP with either PP (Cousin Biotech®) or PVDF (DynaMesh®-PRS) mesh between March 2005 and May 2015. Anatomical outcomes were assessed by the Pelvic Organ Prolapse Quantification (POP-Q) system...
November 22, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29170793/clinical-predictors-and-risk-factors-for-vaginal-mesh-extrusion
#18
Usah Khrucharoen, Patkawat Ramart, Judy Choi, Diana Kang, Ja-Hong Kim, Shlomo Raz
PURPOSES: Our study aims to enhance the accuracy of the clinical diagnosis in patients with vaginal mesh extrusion following transvaginal mesh placement for pelvic organ prolapse using significant clinical parameters and risk factors. METHODS: All patients who underwent vaginal mesh removal were retrospectively reviewed from January 2000 to May 2014. Eligible patients were divided into two groups according to the presence of vaginal mesh extrusion. RESULTS: A total of 862 patients, 798 were included...
November 24, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29170509/measuring-tissue-displacement-of-the-anterior-vaginal-wall-using-the-novel-aspiration-technique-in-vivo
#19
Barbara Röhrnbauer, Cornelia Betschart, Daniele Perucchini, Michael Bajka, Daniel Fink, Caroline Maake, Edoardo Mazza, David Amos Scheiner
Little is known about the mechanical properties of pelvic floor structures and their role in the course and treatment of pelvic organ prolapse (POP). We hypothesize that in vivo mechanical properties of the vaginal wall are related to the appearance of POP and pre-and post-operative states. We used a suction device for intravaginal application, the aspiration device, to evaluate two in vivo mechanical parameters of the anterior vaginal wall, the load dependent tissue displacement and the initial displacement, by image analysis in pre- and post-menopausal women with (POP) and without (control) cystocele (POP: pre-menopausal: N = 6, post-menopausal: N = 19, control: pre-menopausal: N = 17, post-menopausal: N = 6)...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29169582/history-of-cervical-insufficiency-increases-the-risk-of-pelvic-organ-prolapse-and-stress-urinary-incontinence-in-parous-women
#20
David Sheyn, Kateena L Addae-Konaedu, Alison M Bauer, Konyinsola I Dawodu, David N Hackney, Sherif A El-Nashar
OBJECTIVE: A likely contributor to pelvic floor disorders is injury and degradation of connective tissue components such as collagen and elastin, leading to weakening of the pelvic floor. Prior studies have found similar connective tissue component changes in women with cervical insufficiency (CI). However, the connection between pelvic floor disorders and cervical insufficiency has not previously been evaluated. Our objective was to determine whether a history of cervical insufficiency is associated with an increased risk of pelvic organ prolapse and stress urinary incontinence after controlling for confounders...
January 2018: Maturitas
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