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apnea and endocrinology

Şule Yıldırım, Fatih Köksal Binnetoğlu, Fatih Battal, Hakan Aylanç, Nazan Kaymaz, Mustafa Tekin, Naci Topaloğlu, Zuhal Aşık
INTRODUCTION: We aimed to evaluate the relation between QT variables and left ventricular geometry in athletes and obese children. MATERIAL AND METHODS: This study included 209 children and adolescents. Thirty-eight of them were obese, 140 were athletes and 31 were normal weighted. Children with history of functional and structural cardiovascular diseases (acquired and congenital), chronic systemic diseases, hypertension, sleep apnea, endocrinological disorders were excluded...
February 2016: Acta Médica Portuguesa
Azita Tavasoli, Shabnam Jalilolghadr, Shiva Lotfi
OBJECTIVE: This study was conducted to investigate the sleep symptoms and polysomnographic patterns of obstructive sleep apnea in overweight and obese children. MATERIALS & METHODS: Overweight or obese children aging 6-18 yr old referred during 2010 to Endocrinology Clinic of Ghods Hospital in Ghazvin, central Iran were enrolled in the study. Polysomnography was done for the diagnosis of obstructive sleep apnea and the BEARS and Children's Sleep Habits questionnaires were used to survey sleep behaviors...
2016: Iranian Journal of Child Neurology
Mads Christian Johannes Barloese
Cluster headache is characterized by unilateral attacks of severe pain accompanied by cranial autonomic features. Apart from these there are also sleep-related complaints and strong chronobiological features. The interaction between sleep and headache is complex at any level and evidence suggests that it may be of critical importance in our understanding of primary headache disorders. In cluster headache several interactions between sleep and the severe pain attacks have already been proposed. Supported by endocrinological and radiological findings as well as the chronobiological features, predominant theories revolve around central pathology of the hypothalamus...
2015: Journal of Headache and Pain
Puhong Zhang, Rui Zhang, Fang Zhao, Emma Heeley, Ching L Chai-Coetzer, Jing Liu, Bo Jing, Ping Han, Qifu Li, Liao Sun, Yufeng Li, Shengying Dong, Xiaozhen Jiang, Chunhua Zhang, Jinhui Lu, Xingduan Guo, Lixin Guo, R Doug Mcevoy, Linong Ji
Data on the prevalence of obstructive sleep apnea in subjects with type 2 diabetes mellitus in China is scarce. We conducted a multi-centre, cross-sectional study involving 12 hospitals from six regional cities to investigate the prevalence of obstructive sleep apnea in hospitalized patients with type 2 diabetes mellitus and to explore the association between obstructive sleep apnea and related risk factors, diabetic complications and comorbidities in China. Each hospital recruited at least 70 consecutive patients with type 2 diabetes mellitus who were admitted to the endocrinology ward...
February 2016: Journal of Sleep Research
Ibrahim Erdim, Teoman Akcay, Rasim Yilmazer, Omer Erdur, Fatma Tulin Kayhan
OBJECTIVE: To investigate whether there is an association between metabolic syndrome and obstructive sleep apnea syndrome (OSAS) in obese adolescents. METHODS: In total, 240 pubertal children or prepubertal children older than 11 y recruited consecutively from the pediatric endocrinology unit, obesity clinic. Patients with tonsillar and adenoid hypertrophy (grade 3/4), systemic illnesses, or chronic drug usage were excluded. After anthropometric measurement and laboratory study, patients were divided into two groups according to metabolic syndrome (MS): MS and non-MS...
December 15, 2015: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
F Ceccato, E Bernkopf, C Scaroni
Obstructive sleep apnea syndrome (OSAS) is a chronic condition with a high prevalence (up to 7 % of the general population) characterized by frequent episodes of upper airway collapse while sleeping. Left untreated, OSAS can cause severe complications, including systemic hypertension, cardiovascular disease, stroke, and abnormal glucose metabolism. This review aims to summarize the close links between OSAS, endocrinology, and metabolism. In patients with metabolic syndrome, OSAS is an independent risk factor for the onset of type 2 diabetes and a worsening glycemic control...
August 2015: Journal of Endocrinological Investigation
Pinaki Dutta, Abhishek Hajela, Ashish Pathak, Anil Bhansali, Bishan Das Radotra, Rakesh Kumar Vashishta, Márta Korbonits, Niranjan Khandelwal, Rama Walia, Naresh Sachdeva, Paramjeet Singh, Rajagopalan Murlidharan, Jagtar Singh Devgun, Kanchan Kumar Mukherjee
AIM: The diagnosis and treatment of acromegaly, a rare and possibly curable disease, has undergone a paradigm shift in the past few decades. Our aim was to study the changing trends in clinical presentation, management and outcome of the disease in the last fifteen years. METHODOLOGY: 271 consecutive patients with acromegaly treated at the Departments of Endocrinology and Neurosurgery, PGIMER, Chandigarh, between 2000 and 2014, were included in the study. Clinical and hormonal profiles, comorbidities, treatment modalities, outcome and mortality data were evaluated...
May 2015: Neurology India
Marcio C Mancini
Obesity is a major public health problem, is associated with increased rates of mortality risk and of developing several comorbidities, and lessens life expectancy. Bariatric surgery is the most effective treatment for morbidly obese patients, reducing risk of developing new comorbidities, health care utilization and mortality. The establishment of centers of excellence with interdisciplinary staff in bariatric surgery has been reducing operative mortality in the course of time, improving surgical safety and quality...
December 2014: Arquivos Brasileiros de Endocrinologia e Metabologia
Juliana Alves de Sousa Caixêta, Alex Martins Saramago, Marcia Lourdes de Cácia Pradella-Hallinan, Gustavo Antônio Moreira, Sergio Tufik, Reginaldo Raimundo Fujita
BACKGROUND: Sleep-disordered breathing is caused by the interaction of multiple factors, including tonsillar hypertrophy, retrognathia, maxillary atresia, neuromuscular abnormalities, activation of inflammatory mediator cascades, and obesity. The prevalence and severity of obesity among children and adolescents increased worldwide during recent decades and has thus become a public health concern. The aim of this study is to assess the metabolic and anthropometric changes associated with sleep-disordered breathing in obese children...
March 2015: Sleep & Breathing, Schlaf & Atmung
Tamara Brainard
A 36-year-old active duty male with migraine headaches presented for evaluation of poorly controlled hypertension. The workup included an endocrinological examination, which revealed a moderately elevated urine normetanephrine level, suggesting the possibility of a pheochromocytoma. The evaluation also included a sleep study for possible obstructive sleep apnea (OSA) because of a history of snoring, apneic episodes, and daytime somnolence. The sleep study confirmed the diagnosis of OSA. The patient was treated with continuous positive airway pressure therapy and a plasma normetanephrine level demonstrated improvement, but persistent elevation...
January 2014: Military Medicine
Richard S Legro, Silva A Arslanian, David A Ehrmann, Kathleen M Hoeger, M Hassan Murad, Renato Pasquali, Corrine K Welt
OBJECTIVE: The aim was to formulate practice guidelines for the diagnosis and treatment of polycystic ovary syndrome (PCOS). PARTICIPANTS: An Endocrine Society-appointed Task Force of experts, a methodologist, and a medical writer developed the guideline. EVIDENCE: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence...
December 2013: Journal of Clinical Endocrinology and Metabolism
Mary A Nevin
The prevalence of obesity in the pediatric population has dramatically increased in the last 30 years. While the adverse health effects of obesity have long been recognized in adults, many of these complications are now understood to begin in early childhood. Obese children and adolescents are significantly more likely than their peers of healthy weight to suffer from obstructive sleep apnea and metabolic syndrome. In turn, affected individuals may experience myriad serious clinical sequelae; neuro-cognitive, psychiatric, cardiovascular, and endocrinologic complications have each been extensively documented...
October 2013: Pediatric Annals
Carlos Zamarrón, Luis Valdés Cuadrado, Rodolfo Alvarez-Sala
Obstructive sleep apnea syndrome (OSAS) is a highly prevalent sleep disorder, characterized by repeated disruptions of breathing during sleep. This disease has many potential consequences including excessive daytime sleepiness, neurocognitive deterioration, endocrinologic and metabolic effects, and decreased quality of life. Patients with OSAS experience repetitive episodes of hypoxia and reoxygenation during transient cessation of breathing that provoke systemic effects. Furthermore, there may be increased levels of biomarkers linked to endocrine-metabolic and cardiovascular alterations...
2013: Pulmonary Medicine
Jenny Berini, Valeria Spica Russotto, Paolo Castelnuovo, Stefania Di Candia, Luigi Gargantini, Graziano Grugni, Lorenzo Iughetti, Luigi Nespoli, Luana Nosetti, Giovanni Padoan, Alba Pilotta, Giuliana Trifirò, Giuseppe Chiumello, Alessandro Salvatoni
CONTEXT: Adenotonsillar tissue hypertrophy and obstructive sleep apnea have been reported during short-term GH treatment in children with Prader-Willi syndrome (PWS). OBJECTIVE: We conducted an observational study to evaluate the effects of long-term GH therapy on sleep-disordered breathing and adenotonsillar hypertrophy in children with PWS. DESIGN: This was a longitudinal observational study. PATIENTS AND METHODS: We evaluated 75 children with genetically confirmed PWS, of whom 50 fulfilled the criteria and were admitted to our study...
September 2013: Journal of Clinical Endocrinology and Metabolism
M J Aguilar Cordero, A M Sánchez López, N Mur Villar, A Sánchez Marenco, R Guisado Barrilao
Recent studies show an alarming increase in the rate of overweight / obesity among the infant - juvenile population. Obesity in childhood is associated with a significant number of complications, such as sleep apnea syndrome, insulin resistance and type 2 diabetes, hypertension, cardiovascular disease and some cancers. It is estimated that the prevalence of sleep apnea in children is 2-3% in the general population, while in obese adolescents, varies between 13% and 66%, according to various studies. It is associated with impairment of neurocognitive function, behavior, cardiovascular system, metabolic disorders and growth...
May 2013: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Aya Sakai, Hirohisa Toga, Osamu Tachibana, Takaki Miwa
Acromegaly is caused by excessive secretion of growth hormone (GH) and presents with a variety of clinical manifestations, including facial disfigurement and abnormally large hands and feet, as well as diabetes mellitus, hypertension, and sleep-disordered breathing (SDB). Although SDB is known to be associated with serious symptoms, there have been few study reports, and no clear consensus has been reached regarding the method of assessment of individual treatments. We report herein on the results of surgical intervention with transsphenoidal surgery (TSS) for acromegaly and assessment of the treatment effect after the intervention...
May 2013: Nihon Jibiinkoka Gakkai Kaiho
Antonio Bianchi, Ferdinando Valentini, Raffaella Iuorio, Maurizio Poggi, Roberto Baldelli, Marina Passeri, Antonella Giampietro, Linda Tartaglione, Sabrina Chiloiro, Marialuisa Appetecchia, Patrizia Gargiulo, Andrea Fabbri, Vincenzo Toscano, Alfredo Pontecorvi, Laura De Marinis
BACKGROUND: Pegvisomant (PEGV) is widely used, alone or with somatostatin analogs (SSA), for GH-secreting pituitary tumors poorly controlled by SSAs alone. No information is available on specific indications for or relative efficacies of PEGV+SSA versus PEGV monotherapy. Aim of our study was to characterize real-life clinical use of PEGV vs. PEGV+SSA for SSA-resistant acromegaly (patient selection, long-term outcomes, adverse event rates, doses required to achieve control). METHODS: A retrospective analysis of data collected in 2005-2010 in five hospital-based endocrinology centers in Rome was performed...
June 21, 2013: Journal of Experimental & Clinical Cancer Research: CR
Maria Korpal-Szczyrska, Dorota Birkholz, Maja Okońska, Małgorzata Pawłowicz, Józef Szczyrski
UNLABELLED: An 11-year old girl with multihormonal pituitary deficiency previously cured from craniopharyngioma was admitted to the endocrinology Department because of pathological daytime sleepiness. At the age of 7 she had undergone brain tumor surgery with adjuvant radiotherapy (complete dose of 5400 cGy). She had been given replacement therapy of thyroid hormone, cortisol and adiuretin. At the age of 10 years she had started growth hormone (rGH) treatment. After a period of four months of rGH replacement therapy the girl's mother had observed symptoms of excessive daytime sleepiness with a tendency to escalation...
2012: Pediatric Endocrinology, Diabetes, and Metabolism
Turkan Mete, Yavuz Yalcin, Dilek Berker, Bulent Ciftci, Selma Guven Firat, Oya Topaloglu, Halise Cinar Yavuz, Serdar Guler
Obstructive sleep apnea syndrome (OSAS) is a widespread disorder characterized by recurrent, partial, or complete episodes of apnea due to upper airway tract obstruction during sleep. OSAS frequency is likely to increase in hypothyroidism because of obesity, macroglossia, dysfunctional upper respiratory tractus (URT) musculature, deposition of mucopolysaccharides in URT tissues, and decreased ventilatory control. This study examines the relationship between OSAS and thyroid disease in OSAS subjects. This study includes 150 polysomnographically diagnosed OSAS patients (50 mild, 50 moderate, 50 severe OSAS cases) treated at Endocrinology and Metabolism Department of Ankara Numune Training and Research Hospital between January 2010 and May 2011 and 32 non-OSAS control subjects...
December 2013: Endocrine
T Mete, Y Yalcin, D Berker, B Ciftci, S F Guven, O Topaloglu, H C Yavuz, S Guler
BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is a widespread disorder characterized by recurrent, partial or complete episodes of apnea due to upper airway tract obstruction during sleeping period. Deficiency of vitamin D has roles in development of many diseases. Association between presence and severity of OSAS and vitamin D has recently gained research interest. AIM: The aim of our study was to investigate the association between serum 25-hydroxy [25 (OH)] vitamin D levels and severity of disease in patients with OSAS...
October 2013: Journal of Endocrinological Investigation
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