Gene G Chai, Quyen Tu, Menino O Cotta, Michelle J Bauer, Ross Balch, Charles Okafor, Tracy Comans, Peter Kruger, Jason Meyer, Kiran Shekar, Kara Brady, Cheryl Fourie, Natalie Sharp, Luminita Vlad, David Whiley, Jacobus P J Ungerer, Brett C Mcwhinney, Andras Farkas, David L Paterson, Julia E Clark, Krispin Hajkowicz, Sainath Raman, Seweryn Bialasiewicz, Jeffrey Lipman, Brian M Forde, Patrick N A Harris, Luregn J Schlapbach, Lachlan Coin, Jason A Roberts, Adam D Irwin
PURPOSE: Early recognition and effective treatment of sepsis improves outcomes in critically ill patients. However, antibiotic exposures are frequently suboptimal in the intensive care unit (ICU) setting. We describe the feasibility of the Bayesian dosing software Individually Designed Optimum Dosing Strategies (ID-ODS™), to reduce time to effective antibiotic exposure in children and adults with sepsis in ICU. METHODS: A multi-centre prospective, non-randomised interventional trial in three adult ICUs and one paediatric ICU...
March 13, 2024: Intensive Care Medicine