Jennifer H Madenspacher, Eric D Morrell, Jeffrey G McDonald, Bonne M Thompson, Yue Li, Konstantin G Birukov, Anna A Birukova, Renee D Stapleton, Aidin Alejo, Peer W Karmaus, Julie M Meacham, Prashant Rai, Carmen Mikacenic, Mark M Wurfel, Michael B Fessler
Cholesterol-25-hydroxylase (CH25H), the biosynthetic enzyme for 25-hydroxycholesterol (25HC), is most highly expressed in the lung, but its role in lung biology is poorly defined. Recently, we reported that Ch25h is induced in monocyte-derived macrophages recruited to the airspace during resolution of lung inflammation and that 25HC promotes Liver X Receptor (LXR)-dependent clearance of apoptotic neutrophils by these cells. Ch25h and 25HC are, however, also robustly induced by lung-resident cells during the early hours of lung inflammation, suggesting additional cellular sources and targets...
February 23, 2023: JCI Insight