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https://www.readbyqxmd.com/read/28219366/bacteriology-of-the-conjunctiva-in-pre-cataract-surgery-patients-with-occluded-nasolacrimal-ducts-and-the-operation-outcomes-in-japanese-patients
#1
Yuko Hayashi, Takeshi Miyamoto, Shuko Fujita, Katsuo Tomoyose, Nobuyuki Ishikawa, Masahide Kokado, Takayoshi Sumioka, Yuka Okada, Shizuya Saika
BACKGROUND: Contamination of the conjunctiva in association with nasolacrimal duct obstruction is by all accounts a risk factor for infectious endophthalmitis post-cataract surgery. METHODS: All patients who underwent cataract day surgery routinely received nasolacrimal duct syringing with normal saline at the Wakayama Medical University Hospital, Japan, from 2011 to 2013. The microorganisms isolated from conjunctival swab samples of patients with occluded nasolacrimal ducts and their susceptibility to antibiotics, as well as the operation outcomes in all the patients were retrospectively investigated...
February 20, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28215861/effects-of-anthelmintic-treatment-and-feed-supplementation-on-parasite-infections-and-morbidity-parameters-in-cambodian-cattle
#2
Veronique Dermauw, Sothy Meas, Bunthon Chea, Thierry Onkelinx, San Sorn, Davun Holl, Johannes Charlier, Jozef Vercruysse, Pierre Dorny
Helminth infections are the cause of morbidity in Cambodian cattle but other factors such as nutritional deficiencies and concurrent diseases may enhance the effects of parasites. The present study aimed to investigate the impact of anthelmintic treatment, feed supplementation, or both on gastrointestinal strongyle (GIS) and trematode infections as well as on morbidity parameters in Cambodian village cattle. At the beginning of the dry season, cattle populations in six villages were randomly assigned to a group: (A) receiving anthelmintic treatment (ivermectin+clorsulon) at week 0; (P) feed pellet supplementation during week 0-13 or both (AP)...
February 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28209324/japanese-guidelines-for-allergic-conjunctival-diseases-2017
#3
REVIEW
Etsuko Takamura, Eiichi Uchio, Nobuyuki Ebihara, Shigeaki Ohno, Yuichi Ohashi, Shigeki Okamoto, Naoki Kumagai, Yoshiyuki Satake, Jun Shoji, Yayoi Nakagawa, Kenichi Namba, Kazumi Fukagawa, Atsuki Fukushima, Hiroshi Fujishima
The definition, classification, pathogenesis, test methods, clinical findings, criteria for diagnosis, and therapies of allergic conjunctival disease are summarized based on the Guidelines for Clinical Management of Allergic Conjunctival Disease (Second Edition) revised in 2010. Allergic conjunctival disease is defined as "a conjunctival inflammatory disease associated with a Type I allergy accompanied by some subjective or objective symptoms." Allergic conjunctival disease is classified into allergic conjunctivitis, atopic keratoconjunctivitis, vernal keratoconjunctivitis, and giant papillary conjunctivitis...
February 10, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28207432/spontaneous-canalicular-plug-erosion-after-punctal-plug-placement
#4
Xinxin Zhang, Maya Bitar, Richard M Davis
PURPOSE: To describe a case of keratoconjunctivitis sicca treated with punctal plug placement with the first reported complication of subsequent plug erosion through the canaliculus and extrusion through the lid. METHODS: Punctal plugs were placed in a patient with Sjogren syndrome for treatment of keratoconjunctivitis sicca. More than 12 years later, the plug was noted to have eroded through the canaliculus and extruded through the conjunctiva and lid. RESULTS: The extruded plug was removed, and punctal cautery was performed on 2 other puncta with improved symptom control...
February 15, 2017: Cornea
https://www.readbyqxmd.com/read/28203050/normal-flora-of-conjunctiva-and-lid-margin-as-well-as-its-antibiotic-sensitivity-in-patients-undergoing-cataract-surgery-at-phramongkutklao-hospital
#5
Ravee Ratnumnoi, Narumon Keorochana, Chavalit Sontisombat
OBJECTIVE: This study aimed to evaluate the normal flora of conjunctiva and lid margin, as well as its antibiotic sensitivity. DESIGN: This was a prospective cross-sectional study. PATIENTS AND METHODS: A prospective study was conducted on 120 patients who underwent cataract surgery at the Phramongkutklao Hospital from September 2014 to October 2014. Conjunctival and lid margin swabs were obtained from patients before they underwent cataract surgery...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28170093/topical-treatments-for-blepharokeratoconjunctivitis-in-children
#6
REVIEW
Michael O'Gallagher, Catey Bunce, Melanie Hingorani, Frank Larkin, Stephen Tuft, Annegret Dahlmann-Noor
BACKGROUND: Blepharokeratoconjunctivitis (BKC) is a type of inflammation of the surface of the eye and eyelids that involves changes of the eyelids, dysfunction of the meibomian glands, and inflammation of the conjunctiva and cornea. Chronic inflammation of the cornea can lead to scarring, vascularisation and opacity. BKC in children can cause significant symptoms including irritation, watering, photophobia and loss of vision from corneal opacity, refractive error or amblyopia.Treatment of BKC is directed towards modification of meibomian gland disease and the bacterial flora of lid margin and conjunctiva, and control of ocular surface inflammation...
February 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28165428/proteomic-analysis-of-various-rat-ocular-tissues-after-ischemia-reperfusion-injury-and-possible-relevance-to-acute-glaucoma
#7
Hsin-Yi Chen, Hsiu-Chuan Chou, Shing-Jyh Chang, En-Chi Liao, Yi-Ting Tsai, Yu-Shan Wei, Ji-Min Li, Li-Hsun Lin, Meng-Wei Lin, Ying-Jen Chen, Yu-Sheng Chen, Chih-Chun Lin, Yi-Shiuan Wang, Mei-Lan Ko, Hong-Lin Chan
Glaucoma is a group of eye diseases that can cause vision loss and optical nerve damage. To investigate the protein expression alterations in various intraocular tissues (i.e., the cornea, conjunctiva, uvea, retina, and sclera) during ischemia-reperfusion (IR) injury, this study performed a proteomic analysis to qualitatively investigate such alterations resulting from acute glaucoma. The IR injury model combined with the proteomic analysis approach of two-dimensional difference gel electrophoresis (2D-DIGE) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was used to monitor the protein expression alterations in two groups of specimens (an IR injury group and a control group)...
February 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28165063/heavy-chain-hyaluronan-pentraxin-3-from-amniotic-membrane-suppresses-inflammation-and-scarring-in-murine-lacrimal-gland-and-conjunctiva-of-chronic-graft-versus-host-disease
#8
Yoko Ogawa, Hua He, Shin Mukai, Toshihiro Imada, Shigeru Nakamura, Chen-Wei Su, Megha Mahabole, Scheffer C G Tseng, Kazuo Tsubota
Chronic graft-versus-host disease (cGVHD) is a major complication of hematopoietic stem cell transplantation. Dry eye disease is the prominent ocular sequel of cGVHD and is caused by excessive inflammation and fibrosis in the lacrimal glands. Heavy chain-Hyaluronan/Pentraxin 3 (HC-HA/PTX3) is a complex purified from human amniotic membrane (AM) and known to exert anti-inflammatory and anti-scarring actions. In this study, we utilized a mouse model of cGVHD to examine whether HC-HA/PTX3 could attenuate dry eye disease elicited by cGVHD...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28160124/-long-term-results-of-the-compatibility-of-a-coralline-hydroxyapatite-implant-as-eye-replacement
#9
R Thiesmann, A Anagnostopoulos, B Stemplewitz
BACKGROUND: Coralline hydroxyapatite has been used since 1983 as volume replacement. Through 2001, a total of 200 hydroxyapatite implants were used in our department. OBJECTIVE: This prospective study was undertaken to measure the subjective and objective long-term tolerance of this implant. MATERIALS AND METHODS: In 2012, a total of 20 patients were examined, who were enucleated or eviscerated between 1993 and 2001 (average follow-up 16...
February 3, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28152584/a-wide-temporal-window-for-conjunctival-papillae-development-ensures-the-formation-of-a-complete-sclerotic-ring
#10
Karyn Jourdeuil, Tamara Anne Franz-Odendaal
BACKGROUND: The conjunctival papillae are epithelial thickenings of the conjunctiva that are required for the induction of underlying bones (the scleral ossicles). These transient papillae develop and become inductively active over an extended temporal period (HH 30-36, 6.5-10 dpf). While their inductive capacity was discovered in the mid-1900s, little is known about their development. RESULTS: Through a series of timed surgical ablations followed by in situ hybridization for Bmp2, we show that the ring of conjunctival papillae is not altered if the conjunctival epithelium is ablated either prior to or shortly after papillae induction (i...
February 2, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28149490/occurrence-of-chlamydophila-felis-feline-herpesvirus-1-and-calcivirus-in-domestic-cats-of-iran
#11
Nadi Maazi, Shahram Jamshidi, Payman Kayhani, Hassan Momtaz
BACKGROUND AND OBJECTIVES: Feline herpesvirus-1, feline calicivirus and Chlamydophila felis are the main causes of feline upper respiratory tract disease. This study was conducted to identify of FeHV-1, FCV and C. felis infections in domestic cat population and also to estimate the prevalence of each specific infection in Iran. MATERIALS AND METHODS: The ocular conjunctiva and oropharyngeal specimens obtained from 80 cats were examined using PCR and reverse transcription PCR...
October 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/28146368/roles-of-il-6-in-ocular-inflammation-a-review
#12
Hassan Ghasemi
PURPOSE: This review represents the current in vitro, in vivo animal and human researches on the roles of IL-6 in inflammatory ocular disorders. Data sources were literature reviewed using PubMed, Medline, and ISI Databases (since 1981 to late 2016). Search items included interleukine-6 (IL-6); chemokine; cytokine, alone or in combination with serum, aqueous, vitreous, eye, ocular, ophthalmic, and review. RESULTS: IL-6 is found to be involved in ocular inflammation...
February 1, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28139882/oxidized-low-density-lipoprotein-lipid-and-calcium-aggregates-reveal-oxidative-stress-and-inflammation-in-the-conjunctiva-of-glaucoma-patients
#13
Minna Helin-Toiviainen, Seppo Rönkkö, Kai Kaarniranta, Tuomo Puustjärvi, Petri Rekonen, Minna Ollikainen, Hannu Uusitalo
PURPOSE: Conjunctival specimens from primary open-angle glaucoma (POAG), exfoliation glaucoma (ExG) patients and controls were histologically analysed for oxidized low-density lipoprotein (ox-LDL), lipid and calcium aggregates. Our goal was to use them as biomarkers of oxidative stress and inflammation and to evaluate their correlation with glaucoma and impact on surgical outcome. METHODS: Conjunctival samples were obtained from POAG (n = 14) and ExG (n = 17) patients and from control subjects (n = 11) operated for macular hole, retinal detachment or strabismus...
January 31, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28138334/atopic-keratoconjunctivitis-complicated-by-kocuria-koreensis-keratitis-the-first-case
#14
Noriko Inada, Jun Shoji, Satoru Yamagami
BACKGROUND: Patients with atopic dermatitis have a predisposition to Staphylococcus aureus and a Herpes simplex virus infection. The treatment of atopic diseases with steroid and immunosuppressive agents induces opportunistic infection. However, there is a concern regarding visual prognosis in patients with atopic keratoconjunctivitis (AKC) complicated with infectious keratitis. We report an unusual case of an atopic shield ulcer with Kocuria keratitis. CASE PRESENTATION: A 51-year-old Japanese man presented with a 14-day history of eye pain and visual loss in his left eye...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28129025/outcomes-of-levator-advancement-and-m%C3%A3-ller-muscle-conjunctiva-resection-for-the-repair-of-upper-eyelid-ptosis
#15
G N Thomas, J Chan, G Sundar, S Amrith
Both the Müller muscle-conjunctiva resection (MMCR) and levator advancement (LA) procedures can be used to manage ptosis in patients with good levator function. The aim of this article is to evaluate the efficacy and cosmetic outcomes of the two procedures. The clinical records of 29 consecutive eyelids of 26 patients undergoing MMCR and 30 eyelids of 23 patients undergoing LA were analysed. Eleven (42%) in the LA group and 9 (39%) in the MMCR group were male. The preoperative eyelid measurements were significantly different in the LA compared to the MMCR groups, in terms of palpebral aperture (PA) (6...
February 2017: Orbit
https://www.readbyqxmd.com/read/28119075/topical-ocular-treatment-with-monoclonal-antibody-fab-fragments-targeting-japanese-cedar-pollen-cry-j-1-inhibits-japanese-cedar-pollen-induced-allergic-conjunctivitis-in-mice
#16
Nobuaki Mizutani, Takeshi Nabe, Shin Yoshino
Fab fragments (Fabs) of antibodies having the ability only to bind to specific allergens lack effector functions due to the absence of the Fc portion. In the present study, we examined whether IgG1 monoclonal antibody (mAb) Fabs targeting Japanese cedar pollen (JCP) Cry j 1 were able to regulate JCP-induced allergic conjunctivitis in mice. BALB/c mice actively sensitized with JCP were repeatedly challenged by topical administration of JCP eye drops. Fabs prepared by the digestion of anti-JCP IgG1 mAbs (P1-3 and P1-8) with papain were applied to the eye 15min before the JCP challenges followed by measurement of the clinical conjunctivitis score...
January 21, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28115508/eye-drop-inoculation-leads-to-sublethal-leptospirosis-in-mice
#17
Joseph Pierce Sullivan, Nisha Nair, Hari-Hara Potula, Maria Gomes-Solecki
Leptospirosis is potentially a fatal zoonosis acquired by contact of skin and mucosal surfaces with soil and water contaminated with infected urine. We analyzed the outcome of infection of C3H-HeJ mice with Leptospira interrogans serovar Copenhageni, using an enzootic mode of transmission, the conjunctival route. Infection led to weight loss and L. interrogans dissemination from blood to urine. However, the sequence of these events occurred later and were not as clearly separated in time given that spirochete detection overlapped in both tissues...
January 23, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28114570/sustained-subconjunctival-delivery-of-infliximab-protects-the-cornea-and-retina-following-alkali-burn-to-the-eye
#18
Chengxin Zhou, Marie-Claude Robert, Vassiliki Kapoulea, Fengyang Lei, Anna M Stagner, Frederick A Jakobiec, Claes H Dohlman, Eleftherios I Paschalis
Purpose: Tumor necrosis factor (TNF)-α is upregulated in eyes following corneal alkali injury and contributes to corneal and also retinal damage. Prompt TNF-α inhibition by systemic infliximab ameliorates retinal damage and improves corneal wound healing. However, systemic administration of TNF-α inhibitors carries risk of significant complications, whereas topical eye-drop delivery is hindered by poor ocular bioavailability and the need for patient adherence. This study investigates the efficacy of subconjunctival delivery of TNF-α antibodies using a polymer-based drug delivery system (DDS)...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28114364/eyelash-epilation-in-the-absence-of-trichiasis-results-of-a-population-based-prevalence-survey-in-the-western-division-of-fiji
#19
Colin Macleod, Chelsea Yalen, Robert Butcher, Umesh Mudaliar, Kinisimere Natutusau, Mere Rainima-Qaniuci, Chris Haffenden, Conall Watson, Naomi Cocks, Luisa Cikamatana, Chrissy H Roberts, Michael Marks, Eric Rafai, David C W Mabey, Mike Kama, Anthony W Solomon
BACKGROUND: The WHO definition of trachomatous trichiasis (TT) is "at least one eyelash touching the globe, or evidence of recent epilation of in-turned eyelashes", reflecting the fact that epilation is used as a self-management tool for TT. In Fiji's Western Division, a high TT prevalence (8.7% in those aged ≥15 years) was reported in a 2012 survey, yet a 2013 survey found no TT and Fijian ophthalmologists rarely see TT cases. Local anecdote suggests that eyelash epilation is a common behaviour, even in the absence of trichiasis...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28112872/development-of-decellularised-conjunctiva-as-a-substrate-for-the-ex-vivo-expansion-of-conjunctival-epithelium
#20
Shivani Kasbekar, Stephen B Kaye, Rachel L Williams, Rosalind Mk Stewart, Sophie Leow-Dyke, Paul Rooney
PURPOSE: To develop a method to decellularise human conjunctiva. To characterise the tissue in terms of its DNA content, tensile strength, collagen denaturation, basement membrane, extracellular matrix components and its potential to support conjunctival epithelial growth. METHODS: Human conjunctival tissues were subjected to a decellularisation process involving hypotonic detergent and nuclease buffers. Variations in sodium dodecyl sulphate (SDS) concentration (0...
January 23, 2017: Journal of Tissue Engineering and Regenerative Medicine
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