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https://www.readbyqxmd.com/read/29341972/ocular-surface-and-tear-film-characteristics-in-a-sclerodermatous-chronic-graft-versus-host-disease-mouse-model
#1
Jingliang He, Mio Yamane, Shinsuke Shibata, Masaki Fukui, Eisuke Shimizu, Tetsuya Yano, Shin Mukai, Yutaka Kawakami, Shaowei Li, Kazuo Tsubota, Yoko Ogawa
PURPOSE: To report the characteristics of the ocular surface in a previously established sclerodermatous chronic graft-versus-host disease (cGVHD) mouse model. METHODS: The ocular surface features and tear film parameters of the mouse model were assessed by histopathology, immunohistochemistry, electron microscopy, quantitative polymerase chain reaction, and flow cytometry. RESULTS: The mice exhibited loss of body weight and decreased tear secretion (P < 0...
January 16, 2018: Cornea
https://www.readbyqxmd.com/read/29338721/infectious-keratoconjunctivitis-in-semi-domesticated-eurasian-tundra-reindeer-rangifer-tarandus-tarandus-microbiological-study-of-clinically-affected-and-unaffected-animals-with-special-reference-to-cervid-herpesvirus-2
#2
Javier Sánchez Romano, Torill Mørk, Sauli Laaksonen, Erik Ågren, Ingebjørg H Nymo, Marianne Sunde, Morten Tryland
BACKGROUND: Infectious keratoconjunctivitis (IKC) is one of the most common ocular diseases in ruminants worldwide. In addition to keratitis and conjunctivitis, animals with IKC can develop uveitis, corneal ulcer, and in severe cases, blindness. The bacteria Moraxella spp. has been described as the primary causative agent of infectious bovine keratoconjunctivitis (IBK) in cattle (Bos taurus), while Chlamydia spp. and Mycoplasma conjunctivae are considered the main causative agents of IKC in sheep (Ovis aries)...
January 16, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29336627/clinical-severity-classification-using-automated-conjunctival-hyperemia-analysis-software-in-patients-with-superior-limbic-keratoconjunctivitis
#3
Junki Kurita, Jun Shoji, Noriko Inada, Tsuyoshi Yoneda, Tamaki Sumi, Masahiko Kobayashi, Yasuhiro Hoshikawa, Atsuki Fukushima, Satoru Yamagami
PURPOSE: Digitization of clinical observation is necessary for assessing the severity of superior limbic keratoconjunctivitis (SLK). This study aimed to use a novel quantitative marker to examine hyperemia in patients with SLK. MATERIALS AND METHODS: We included six eyes of six patients with both dry eye disease and SLK (SLK group) and eight eyes of eight patients with Sjögren syndrome (SS group). We simultaneously obtained the objective finding scores by using slit-lamp examination and calculated the superior hyperemia index (SHI) with an automated conjunctival hyperemia analysis software by using photographs of the anterior segment...
January 16, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29321155/plasminogen-replacement-therapy-for-the-treatment-of-children-and-adults-with-congenital-plasminogen-deficiency
#4
Amy D Shapiro, Charles Nakar, Joseph M Parker, Gary R Albert, John E Moran, Karen Thibaudeau, Neelam Thukral, Brandon M Hardesty, Pierre Laurin, Per Morten Sandset
Congenital plasminogen deficiency is caused by mutation(s) in PLG, the gene coding for production of the zymogen plasminogen, and is an ultra-rare disorder associated with abnormal accumulation or growth of fibrin-rich pseudomembranous lesions on mucous membranes, such as the conjunctiva, gingiva, and linings of the airways and genitourinary tract. Left untreated, these lesions may impair normal tissue and organ function, and impact quality of life. Plasminogen replacement therapy should provide an effective treatment of the clinical manifestations of congenital plasminogen deficiency...
January 10, 2018: Blood
https://www.readbyqxmd.com/read/29320451/the-pathogenesis-of-staphylococcus-aureus-eye-infections
#5
REVIEW
Richard J O'Callaghan
Staphylococcus aureus is a major pathogen of the eye able to infect the tear duct, eyelid, conjunctiva, cornea, anterior and posterior chambers, and the vitreous chamber. Of these infections, those involving the cornea (keratitis) or the inner chambers of the eye (endophthalmitis) are the most threatening because of their potential to cause a loss in visual acuity or even blindness. Each of these ocular sites is protected by the constitutive expression of a variety of antimicrobial factors and these defenses are augmented by a protective host response to the organism...
January 10, 2018: Pathogens
https://www.readbyqxmd.com/read/29319641/significance-of-early-postoperative-eyelid-position-on-late-postoperative-result-in-mueller-s-muscle-conjunctival-resection-and-external-levator-advancement-surgery
#6
Jennifer Danesh, Shoaib Ugradar, Robert Goldberg, Naresh Joshi, Daniel B Rootman
PURPOSE: The purpose of this study was to determine whether advancement of the levator aponeurosis in external levator resection surgery or Mueller's muscle and conjunctiva in Mueller's muscle conjunctival resection (MMCR) surgery has a differential effect on variation in eyelid position during the postoperative period. METHODS: In this retrospective observational cohort study, 2 groups of patients were defined. The first underwent MMCR surgery without tarsectomy by surgeon 1...
January 9, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29319444/use-of-2-octyl-cyanoacrylate-for-wound-closure-in-a-modified-roberts-bistner-procedure-for-eyelid-agenesis-in-five-cats-nine-eyes
#7
Zoe Reed, Clinton J Doering, Paul M Barrett
CASE DESCRIPTION 5 cats (9 eyes) were evaluated for surgical correction of bilateral eyelid agenesis. CLINICAL FINDINGS All eyes lacked > 25% of the temporal upper eyelid, and all cats had clinical signs attributable to chronic ocular exposure. Abnormalities were limited to the ocular surface in the 4 female cats, whereas the sole male cat had additional abnormalities consistent with anterior segment dysgenesis. TREATMENT AND OUTCOME A modified Roberts-Bistner procedure involving 2-octyl cyanoacrylate (2OCA) was performed on 9 eyes; 1 eye was enucleated...
January 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29313597/vitamin-d-and-vitamin-d-receptor-in-patients-with-ophthalmic-pterygium
#8
Cristina Maxia, Daniela Murtas, Michela Corrias, Ignazio Zucca, Luigi Minerba, Franca Piras, Cristiana Marinelli, Maria Teresa Perra
Pterygium, an ultraviolet radiation (UV)-related disease, is a relatively benign process, but since it displays tumor-like features, it has been proposed to be a neoplastic- like growth disorder. Vitamin D performs a number of functions in addition to calcium homeostasis, as inhibition of cell proliferation, activation of apoptotic pathways, and inhibition of angiogenesis. Since the antitumor actions of vitamin D are mediated primarily through the nuclear vitamin D receptor (VDR), the aim of the present study was to investigate vitamin D status in patients with pterygium and in control subjects, and VDR immunohistochemical expression in samples of pterygium and normal conjunctiva in order to evaluate a possible role of vitamin D pathway in the pathogenesis of the disease...
October 30, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29303873/case-report-xen-ab-interno-gel-stent-use-in-a-refractory-glaucoma-patient-with-previous-filtration-surgeries
#9
Simrenjeet Sandhu, Michael W Dorey
This case study reports the successful implantation of the Xen ab interno gel stent in a 44-year-old male with refractory chronic open angle glaucoma. The patient had multiple unsuccessful filtration surgeries including a trabeculectomy and two Ahmed glaucoma valves placed superotemporally and inferonasally OD. The patients intraocular pressure was reduced from 29▒mm Hg preoperatively to 17▒mm Hg 1 year after surgery, without any ocular complications. The Xen gel stent may be considered as a possible intervention to lower IOP in patients with refractory glaucoma, despite previous filtration surgeries if the superonasal conjunctiva is spared and healthy...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29297092/conjunctival-melanoma-association-of-cyclooxygenase-2-tumor-expression-to-prognosis
#10
Rita Pinto-Proença, Mariana Santos, Cristina Fonseca, Júlia Fernandes, Maria Filomena Gaspar, Rui Proença
PURPOSE: Conjunctival melanoma is a rare but potentially lethal tumor. Its biologic profile is still largely unknown, with recent studies aiming at establishing histopathological and genetic tumor profiles. The aim of this study was to analyze the association between clinicopathological characteristics and tumor expression of cyclooxygenase-2 (COX-2) to prognosis, assessing its usefulness as a possible prognostic marker. METHODS: Case series of 50 patients from 1991 to 2008 with pathologically proven conjunctival melanoma...
January 2, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29296557/use-of-biodegradable-collagen-glycosaminoglycan-copolymer-matrix-implant-to-reduce-postoperative-fibrosis-in-strabismus-surgery
#11
Thiago Gonçalves Dos Santos Martins, Ana Luiza Fontes de Azevedo Costa, Antonio Carlos Centelhas, Diogo Gonçalves Dos Santos Martins
The occurrence of restrictive strabismus after conjunctival surgeries is widely described in the literature. Fibrosis causes adherence of the conjunctiva to the Tenon's capsule, intermuscular membrane, adipose orbital tissue, sclera, and extraocular muscle tissue. Fibrosis causes adherence of the conjunctiva to the Tenon's capsule, intermuscular membrane, adipose orbital tissue, sclera, and extraocular muscle tissue. We report a case of the use of a biodegradable collagen-glycosaminoglycan copolymer matrix implant (Ologen®) as an alternative adjuvant, used as a spacer to mechanically separate the subconjunctival and episcleral tissues to prevent fibrosis in a patient undergoing a surgical correction for a strabismus with a restrictive component due to previous surgeries of pterygium excision...
October 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29288088/telangiectasias-in-ataxia-telangiectasia-clinical-significance-role-of-atm-deficiency-and-potential-pathophysiological-mechanisms
#12
M H D Schoenaker, N J H Van Os, M Van der Flier, M Van Deuren, M M Seyger, A M R Taylor, C M R Weemaes, M A A P Willemsen
Ataxia Telangiectasia (AT) is named after the two key clinical features that characterize its classical phenotype, namely a progressive cerebellar gait disorder (ataxia) and vascular anomalies (telangiectasias) visible in the conjunctivae and skin. AT is an autosomal recessively inherited disorder, caused by mutations in the ATM gene that encodes the ATM protein. While the ataxia is subject of many publications, the telangiectasias are under emphasised. We here describe the observation that the absence or presence of ATM protein and the level of residual ATM kinase activity are related to the occurrence of telangiectasias and describe the clinical consequences of these vascular malformations...
December 26, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29285278/relationship-between-expression-of-cyclooxygenase-2-and-neovascularization-in-human-pterygia
#13
Dongwei Liu, Chang Peng, Zhengxuan Jiang, Liming Tao
In present study, we are to test the relationship between cyclooxygenase 2 (COX-2) and angiogenesis in pterygium tissues from a group of Chinese patients. Here forty-five primary pterygium tissues and twenty-three normal bulbar conjunctival tissues were obtained during ophthalmologic surgeries. The primary pterygium samples were treated for the immunohistochemical evaluation of COX-2, CD31 and vascular endothelial growth factor (VEGF) antibodies for different tissues. In order to evaluate the relationship between COX-2 and neovascularization, a statistical analysis was performed using the SPSS 13...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29283151/unusual-intraconal-localization-of-orbital-giant-cell-angiofibroma
#14
Meryem Altin Ekin, Seyda Karadeniz Ugurlu, Fulya Cakalagaoglu
Giant cell angiofibroma (GCA) is a recently reported rare soft-tissue tumor that can develop in various sites including orbit. Orbital GCAs were mainly located in the eyelid or extraconal regions such as lacrimal gland and conjunctiva. We report an atypical case of a GCA arising in the intraconal area of the orbit in a 65-year-old male patient. The tumor was excised in total by lateral orbitotomy. Histological and immunohistochemical features were consistent with the diagnosis of GCA. No recurrence was observed during the follow-up of over 2 years...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29283124/topical-chemotherapy-for-giant-ocular-surface-squamous-neoplasia-of-the-conjunctiva-and-cornea-is-surgery-necessary
#15
Sonal S Chaugule, Jennifer Park, Paul T Finger
PURPOSE: The purpose of this study is to report on the efficacy and safety of topical chemotherapy alone for giant ocular surface squamous neoplasia (OSSN). METHODS: In this retrospective, interventional series, 10 eyes with giant OSSN underwent exfoliative biopsy to confirm the diagnosis followed by application of interferon alpha 2b (IFN α2b) and/or 5 fluorouracil, 1% (5FU). Reported outcome measures were tumor response, visual acuity, recurrence, systemic metastasis, and treatment complications...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29282404/baerveldt-scleral-patch-graft-abscess-secondary-to-coagulase-negative-staphylococcus
#16
Van Nguyen, Mason Schmutz, Sarah Farukhi, Sameh Mosaed
We report the case of a 69-year-old female who underwent a Baerveldt implant placement for severe-stage primary open-angle glaucoma and developed a bacterial infection of the conjunctiva and abscess of the scleral patch graft with subsequent tube exposure. The infection was identified 3 weeks postoperatively and a topical antibiotic was immediately initiated. A concurrent systemic staphylococcal infection was discovered by an outside physician and oral cephalexin was initiated. Despite antibiotic treatment, the conjunctival erosion progressed, and tube revision was required...
September 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29282126/the-impact-of-a-single-round-of-community-mass-treatment-with-azithromycin-on-disease-severity-and-ocular-chlamydia-trachomatis-load-in-treatment-na%C3%A3-ve-trachoma-endemic-island-communities-in-west-africa
#17
Anna R Last, Sarah E Burr, Emma Harding-Esch, Eunice Cassama, Meno Nabicassa, Chrissy H Roberts, David C W Mabey, Martin J Holland, Robin L Bailey
BACKGROUND: Trachoma, a neglected tropical disease, is caused by ocular infection with Chlamydia trachomatis (Ct). The World Health Organization (WHO) recommends three annual rounds of community mass drug treatment with azithromycin (MDA) if the prevalence of follicular trachoma in 1-9 year olds (TF1-9) exceeds 10% at district level to achieve an elimination target of district-level TF1-9 below 5% after. To evaluate this strategy in treatment-naïve trachoma-endemic island communities in Guinea Bissau, we conducted a cross-sectional population-based trachoma survey on four islands...
December 28, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29280751/different-genotypes-of-adhesion-operon-genes-in-staphylococcus-epidermidis-isolates-from-various-ocular-infections
#18
Mehrnoush Sharifinejad, Narjes Shokatpour, Farshad Farnaghi, Zohreh Abedinyfar, Fahimeh Asadi Amoli, Farahnoosh Doustdar
BACKGROUND: Staphylococcus epidermidis is one of the common causes of bacterial keratitis and post-operation infections. One of the most important virulence factors of S. epidermidis is biofilm formation. Poly-N-acetylglucosamine (PNAG) production is critical for biofilm formation in S. epidermidis. The intercellular adhesion (ica) operon is formed by icaA, icaD, icaB, and icaC genes, which participate in the biosynthesis of PNAG. Strains of S. epidermidis from different infections show different genotypes in relation to adhesion operon genes...
December 26, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29279847/bacterial-diversity-in-feline-conjunctiva-based-on-16s-rrna-gene-sequence-analysis-a-pilot-study
#19
Katarzyna Płoneczka-Janeczko, Jacek Bania, Karolina Bierowiec, Maciej Kiełbowicz, Zdzisław Kiełbowicz
Changes in the microbial populations in the conjunctival sacs of animals have traditionally been evaluated using conventional microbiology techniques. The goal of this study was to examine the suitability of a methodology which may reveal a previously unknown microbiome inhabiting feline conjunctival membranes. In the present study, we determined the microbial diversity in feline conjunctivas based on 16S rRNA gene sequence analysis. Five taxa not described earlier in veterinary ophthalmology (i.e., Staphylococcus caprae, Staphylococcus succinus, Propionibacterium acnes, Psychrobacter faecalis, and Bacillus subtilis) were identified in feline conjunctivas with a high similarity (99-100%)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29279073/characterization-of-all-surgical-specimens-provided-by-a-portuguese-department-of-ophthalmology-over-a-13-year-period
#20
José Ferreira Mendes, Ana Margarida Ferreira, Cristina Freitas
INTRODUCTION: We intend to evaluate clinically, topographically and morphologically all surgical specimens sent by the Department of Ophthalmology of Hospital de Braga to the Department of Pathology of the same hospital. MATERIAL AND METHODS: Two hundred and fifty eight surgically obtained specimens, from the Department of Ophthalmology of Hospital de Braga, analyzed in the Department of Pathology, from January 2002 to June 2015, were characterized. Data was arranged according to year, age, sex, topography and morphological diagnosis according to the SNOMED® coding system...
November 29, 2017: Acta Médica Portuguesa
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