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https://www.readbyqxmd.com/read/28820679/tuberculosis-related-diabetes-is-it-reversible-after-complete-treatment
#1
Huma Aftab, Dirk L Christensen, Atiqa Ambreen, Mohammad Jamil, Peter Garred, Jørgen H Petersen, Susanne D Nielsen, Ib C Bygbjerg
Individuals with newly diagnosed tuberculosis (TB) were screened for diabetes (DM) with fasting plasma glucose (FPG) in Pakistan. A significant decrease in FPG was observed when TB was treated. Of those with newly diagnosed DM, 46% and 62% no longer had hyperglycemia after 3 and 6 months, respectively. Individuals with known DM also showed a significant decrease in fasting plasma levels when treated for TB, but after 3 months none had normoglycemia, and after 6 months 9.2% were normoglycemic. Thus, TB-related DM may abate when the stress terminates, as is the case in gestational DM...
August 7, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28811292/dapagliflozin-slows-the-progression-of-the-renal-and-liver-fibrosis-associated-with-type-2-diabetes
#2
Li Tang, Yuanyuan Wu, Mi Tian, C David Sjostrom, Ulrika Johansson, Xiao-Rong Peng, David M Smith, Yufeng Huang
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of antidiabetic oral agents indicating promising effects on cardiovascular and renal end points. However, the renoprotective effects of SGLT2 inhibitors are not fully understood. Also, metabolic effects of SGLT2 inhibition on other organ systems such as effects on hepatic steatosis are not fully understood. This study sought to address these questions by treating 18week-old uninephrectomized db/db mice with a selective SGLT2 inhibitor dapagliflozin...
August 15, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28808475/yacon-smallanthus-sonchifolius-leaf-extract-attenuates-hyperglycemia-and-skeletal-muscle-oxidative-stress-and-inflammation-in-diabetic-rats
#3
Klinsmann Carolo Dos Santos, Bianca Guerra Bueno, Luana Ferreira Pereira, Fabiane Valentini Francisqueti, Mariana Gobbo Braz, Lahis Fernandes Bincoleto, Lilian Xavier da Silva, Ana Lúcia A Ferreira, Ana Cláudia de Melo Stevanato Nakamune, C-Y Oliver Chen, Jeffrey B Blumberg, Camila Renata Corrêa
The effects of hydroethanolic extract of Yacon leaves (HEYL) on antioxidant, glycemic, and inflammatory biomarkers were tested in diabetic rats. Outcome parameters included glucose, insulin, interleukin-6 (IL-6), and hydrophilic antioxidant capacity (HAC) in serum and IL-6, HAC, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in soleus. The rats (10/group) were divided as follows: C, controls; C + Y, HEYL treated; DM, diabetic controls; and DM + Y, diabetic rats treated with HEYL...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28790167/chemoprotective-effects-of-butanol-fraction-of-buchholzia-coriacea-capparidaceae-against-type-2-diabetes-and-oxidative-stress-in-male-wistar-rats
#4
Amanda Chikaosolu Okolie, Oluwafemi Ezekiel Kale, Odutola Osilesi
Recent studies have shown that Type 2 diabetes (T2D) in rats can result through a synergy that link obesity to insulin resistance and β-cell dysfunction. This present study achieved T2D via high fructose (20%(w/v), p.o.), streptozotocin single dose (40 mg/kg, i.p.) (HFSTZ) in rats. Also, chemoprotective potential of butanol fraction of buchholzia coriacea (BFBC) was demonstrated. Control normal and diabetic untreated (HFSTZ-induced T2D) rats received carboxymethyl cellulose (1 mg/kg, p.o.). Diabetic rats received intragastric BFBC (20, 200, 400 mg/kg), glibenclamide (0...
August 8, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28767399/effect-of-p53-on-pancreatic-cancer-glucose-tolerance-abnormalities-by-regulating-transglutaminase-2-in-resistance-to-glucose-metabolic-stress
#5
Xiao Su, Xiangyi He, Qiwen Ben, Weiyi Wang, Huan Song, Qiao Ye, Yi Zang, Weiguang Li, Ping Chen, Weiyan Yao, Yaozong Yuan
Pancreatic ductal adenocarcinoma (PanCa) is an extremely lethal disease characterized by mutations of p53 in up to 70% of cases. Our previous studies have confirmed that hyperglycemia may be the first clinical manifestation for the early diagnosis of PanCa. In this article, we showed that targeted knockdown of TG2 or p53 in tumor cells led to decreased cell survival in response to glucose deprivation, while this phenomenon was abolished by combined inhibition of TG2 and p53. We observed that inhibition of TG2 or p53 sensitized glucose deprivation resistance through an intracellular reactive oxygen species (ROS) pathway and the induction of Bcl-2...
July 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28765969/ampk-activation-restores-ischemic-post%C3%A2-conditioning-cardioprotection-in-stz%C3%A2-induced-type-1-diabetic-rats-role-of-autophagy
#6
Bin Zhou, Yan Leng, Shao-Qing Lei, Zhong-Yuan Xia
Although the mechanism remains unclear, ischemic post‑conditioning (IPO) is a promising approach to combat myocardial ischemia reperfusion (IR) injury; however, it has been proven ineffective in diabetes. The present study aimed to identify whether hyperglycemia‑induced AMP‑activated protein kinase (AMPK) inhibition contributes to the ineffectiveness of IPO via autophagy attenuation in diabetic hearts. Diabetic and non‑diabetic rats were subjected to myocardial IR and/or IPO with/without treatment with the AMPK activator A‑769662 and/or autophagy inhibitor 3‑methyladenine (3‑MA)...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28765962/sirt1-activation-inhibits-hyperglycemia-induced-apoptosis-by-reducing-oxidative-stress-and-mitochondrial-dysfunction-in-human-endothelial-cells
#7
Shengqiang Wang, Jian Wang, Airong Zhao, Jigang Li
Sustained hyperglycemic stimulation of vascular cells is involved in the pathogenesis of diabetes mellitus‑induced cardiovascular complications. Silent information regulator T1 (SIRT1), a mammalian sirtuin, has been previously recognized to protect endothelial cells against hyperglycemia‑induced oxidative stress. In the present study, human umbilical vein endothelial cells (HUV‑EC‑C) were treated with D‑glucose, and the levels of oxidative stress, mitochondrial dysfunction, the rate of apoptosis and SIRT1 activity were measured...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28765602/arc-is-essential-for-maintaining-pancreatic-islet-structure-and-%C3%AE-cell-viability-during-type-2-diabetes
#8
Wendy M McKimpson, Min Zheng, Streamson C Chua, Jeffrey E Pessin, Richard N Kitsis
Pancreatic β-cell loss through apoptosis is an important disease mechanism in type 2 diabetes. Apoptosis Repressor with CARD (ARC) is a cell death inhibitor that antagonizes multiple death programs. We previously reported that ARC is abundant in pancreatic β-cells and modulates survival of these cells in vitro. Herein we assessed the importance of endogenous ARC in maintaining islet structure and function in vivo. While generalized loss of ARC did not result in detectable abnormalities, its absence in ob/ob mice, a model of type 2 diabetes, induced a striking pancreatic phenotype: marked β-cell death, loss of β-cell mass, derangements of islet architecture, and impaired glucose-stimulated insulin secretion in vivo...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28763831/preparation-related-structural-diversity-and-medical-potential-in-the-treatment-of-diabetes-mellitus-with-ginseng-pectins
#9
REVIEW
Qilei Chen, Lin Zhu, Yina Tang, Zhongzhen Zhao, Tao Yi, Hubiao Chen
Pectins isolated from Panax ginseng C.A. Meyer are potential therapeutic agents for the treatment of diabetes mellitus, a global health challenge. Soil-to-bench procedures of ginseng pectin preparation significantly affect the polysaccharide structures. Various forms of ginseng pectins rich in homogalacturonan, rhamnogalacturonan-I, rhamnogalacturonan-II, and arabinogalactan have demonstrated independent or collaborative effects on hyperglycemia, oxidative stress, immunological dysfunction, and neoplasms. Monosaccharide compositions, peptide contents, degrees of esterification and methylation, and inter- and intramolecular linkages all influence pectin bioactivity...
August 1, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28760429/evidence-based-recommendations-and-expert-consensus-on-enteral-nutrition-in-the-adult-patient-with-diabetes-mellitus-or-hyperglycemia
#10
Alejandro Sanz-Paris, Julia Álvarez Hernández, María D Ballesteros-Pomar, Francisco Botella-Romero, Miguel León-Sanz, Ángela Martín-Palmero, Miguel Ángel Martínez Olmos, Gabriel Olveira
OBJECTIVE: The aim of this study was to develop evidence-based recommendations for glycemic control of patients with diabetes mellitus or stress hyperglycemia who are receiving enteral nutrition (EN). METHODS: A Delphi survey method using Grading Recommendations Assessment, Development and Evaluation criteria was utilized for evaluation of suitable studies. RESULTS: In patients with diabetes or stress hyperglycemia who were on EN support, the following results were found: CONCLUSIONS: These recommendations and suggestions regarding enteral feeding in patients with diabetes and hyperglycemia have direct clinical applicability...
September 2017: Nutrition
https://www.readbyqxmd.com/read/28758742/effects-of-c-glycosides-from-apios-americana-leaves-against-oxidative-stress-during-hyperglycemia-through-regulating-mitogen-activated-protein-kinases-and-nuclear-factor-erythroid-2-related-factor-2
#11
Fujie Yan, Yunyun Yang, Lushuang Yu, Xiaodong Zheng
Main components of Apios americana leaves extract (ALE) were flavonoid C-glycosides, including vitexin (46.7%), schaftoside (18.9%), and orientin (4.32%). In vitro, ALE restored glucose consumption, glucose uptake, and glycogen content in glucose-induced hepatic cells. Exposure of HepG2 cells to high glucose resulted in reactive oxygen species and O2(-) accumulation, while ALE alleviated these increases by 47 ± 0.68 and 68 ± 0.74%, respectively. Glucose increased c-Jun N-terminal kinase (JNK) and decreased extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38 phosphorylation, while ALE reduced p-JNK and p-p38 but not p-ERK1/2, accompanied by nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1, and NAD(P)H quinine oxidoreductase 1 downregulation...
August 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28758125/antihyperglycemic-and-antihyperlipidemic-activity-of-hydroponic-stevia-rebaudiana-aqueous-extract-in-hyperglycemia-induced-by-immobilization-stress-in-rabbits
#12
Anush Aghajanyan, Zaruhi Movsisyan, Armen Trchounian
Diabetes mellitus (DM) is a serious worldwide problem related to human hyperglycemia. Thus, herbal preparations with antihyperglycemic properties especially leaf extracts of hydroponic Stevia rebaudiana (SR) would be useful in hyperglycemia treatment. The antihyperglycemic potential of this medicinal plant grown using hydroponics methods has been evaluated. Significant reduction of some biochemical characteristics for sugars and fatty acids in blood, liver, and muscle especially fasting glucose levels, serum triglycerides, LDL-cholesterol, total cholesterol levels, and increased HDL-cholesterol ones was shown with SR aqueous extract treatment...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28757338/soluble-epoxide-hydrolase-in-podocytes-is-a-significant-contributor-to-renal-function-under-hyperglycemia
#13
Ahmed Bettaieb, Shinichiro Koike, Ming-Fo Hsu, Yoshihiro Ito, Samah Chahed, Santana Bachaalany, Artiom Gruzdev, Miguel Calvo-Rubio, Kin Sing Stephen Lee, Bora Inceoglu, John D Imig, Jose M Villalba, Darryl C Zeldin, Bruce D Hammock, Fawaz G Haj
BACKGROUND: Diabetic nephropathy (DN) is the leading cause of renal failure, and podocyte dysfunction contributes to the pathogenesis of DN. Soluble epoxide hydrolase (sEH, encoded by Ephx2) is a conserved cytosolic enzyme whose inhibition has beneficial effects on renal function. The aim of this study is to investigate the contribution of sEH in podocytes to hyperglycemia-induced renal injury. MATERIALS AND METHODS: Mice with podocyte-specific sEH disruption (pod-sEHKO) were generated, and alterations in kidney function were determined under normoglycemia, and high-fat diet (HFD)- and streptozotocin (STZ)-induced hyperglycemia...
July 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28757158/a-short-term-high-fat-high-sucrose-diet-in-mice-impairs-optic-nerve-recovery-after-injury-and-this-is-not-reversed-by-exercise
#14
Vicki Chrysostomou, Peter van Wijngaarden, Gregory R Steinberg, Jonathan G Crowston
The aim of the current work was to test whether increased intake of dietary fat and sucrose in mice modifies the response of retinal ganglion cells (RGCs) of the optic nerve to injury, and whether any effects of diet are influenced by physical activity levels. C57BL/6J mice were given a high-fat high-sucrose (HFS) diet for 7 weeks, with or without exposure to regular exercise by swimming (60 min/day, 5 days/week). Injury to RGCs was subsequently induced by acute elevation of intraocular pressure (IOP) and retinas were assessed for function and structure...
September 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28753251/liraglutide-mitigates-tnf-%C3%AE-induced-pro-atherogenic-changes-and-microvesicles-release-in-huvec-from-diabetic-women
#15
Pamela Di Tomo, Paola Lanuti, Natalia Di Pietro, Maria Pompea Antonia Baldassarre, Marco Marchisio, Assunta Pandolfi, Agostino Consoli, Gloria Formoso
BACKGROUND: To evaluate whether exposure to GLP-1 receptor agonist Liraglutide could modulate pro-atherogenic alterations previously observed in endothelial cells obtained by women affected by gestational diabetes, thus exposed in vivo to hyperglycemia, oxidative stress and inflammation and to evaluate endothelial microvesicles (EMV) release, a new reliable biomarker of vascular stress/damage. METHODS: we studied Liraglutide effects and its plausible molecular mechanisms on monocyte cells adhesion and adhesion molecules expression and membrane exposure in control (C-) Human Umbilical Vein Endothelial Cells (HUVEC) as well as in HUVEC of women affected by gestational diabetes (GD) exposed in vitro to TNF-α...
July 28, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28752051/repletion-of-branched-chain-amino-acids-reverses-mtorc1-signaling-but-not-improved-metabolism-during-dietary-protein-dilution
#16
Adriano Maida, Jessica S K Chan, Kim A Sjøberg, Annika Zota, Dieter Schmoll, Bente Kiens, Stephan Herzig, Adam J Rose
OBJECTIVE: Dietary protein dilution (PD) has been associated with metabolic advantages such as improved glucose homeostasis and increased energy expenditure. This phenotype involves liver-induced release of FGF21 in response to amino acid insufficiency; however, it has remained unclear whether dietary dilution of specific amino acids (AAs) is also required. Circulating branched chain amino acids (BCAAs) are sensitive to protein intake, elevated in the serum of obese humans and mice and thought to promote insulin resistance...
August 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28751454/cysteamine-prevents-vascular-leakage-through-inhibiting-transglutaminase-in-diabetic-retina
#17
Yeon-Ju Lee, Se-Hui Jung, Jong Yun Hwang, Sohee Jeon, Eun-Taek Han, Won Sun Park, Seok-Ho Hong, Young-Myeong Kim, Kwon-Soo Ha
Cysteamine (an aminothiol), which is derived from coenzyme A degradation and metabolized into taurine, has beneficial effects against cystinosis and neurodegenerative diseases; however, its role in diabetic complications is unknown. Thus, we sought to determine the preventive effect of cysteamine against hyperglycemia-induced vascular leakage in the retinas of diabetic mice. Cysteamine and ethanolamine, the sulfhydryl group-free cysteamine analogue, inhibited vascular endothelial growth factor (VEGF)-induced stress fiber formation and vascular endothelial (VE)-cadherin disruption in endothelial cells which play a critical role in modulating endothelial permeability...
July 27, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28747974/hyperglycemia-decreases-preoxiredoxin-2-expression-in-a-middle-cerebral-artery-occlusion-model
#18
Phil-Ok Koh
Diabetes is a major risk factor for stroke and is also associated with worsened outcomes following a stroke. Peroxiredoxin-2 exerts potent neuroprotective effects against oxidative stress. In the present study, we identified altered peroxiredoxin-2 expression in an ischemic stroke model under hyperglycemic conditions. Adult male rats were administrated streptozotocin (40 mg/kg) via intraperitoneal injection to induce diabetes. Middle cerebral artery occlusion (MCAO) was induced surgically 4 weeks after streptozotocin treatment and cerebral cortex tissues were isolated 24 hours after MCAO...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28743992/endotoxemia-mediated-activation-of-acetyltransferase-p300-impairs-insulin-signaling-in-obesity
#19
Jia Cao, Jinghua Peng, Hongying An, Qiyi He, Tatiana Boronina, Shaodong Guo, Morris F White, Philip A Cole, Ling He
Diabetes and obesity are characterized by insulin resistance and chronic low-grade inflammation. An elevated plasma concentration of lipopolysaccharide (LPS) caused by increased intestinal permeability during diet-induced obesity promotes insulin resistance in mice. Here, we show that LPS induces endoplasmic reticulum (ER) stress and protein levels of P300, an acetyltransferase involved in glucose production. In high-fat diet fed and genetically obese ob/ob mice, P300 translocates from the nucleus into the cytoplasm of hepatocytes...
July 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28740855/aldose-reductase-inhibitor-protects-against-hyperglycemic-stress-by-activating-nrf2-dependent-antioxidant-proteins
#20
Kirtikar Shukla, Pabitra Bikash Pal, Himangshu Sonowal, Satish K Srivastava, Kota V Ramana
We have shown earlier that pretreatment of cultured cells with aldose reductase (AR) inhibitors prevents hyperglycemia-induced mitogenic and proinflammatory responses. However, the effects of AR inhibitors on Nrf2-mediated anti-inflammatory responses have not been elucidated yet. We have investigated how AR inhibitor fidarestat protects high glucose- (HG-) induced cell viability changes by increasing the expression of Nrf2 and its dependent phase II antioxidant enzymes. Fidarestat pretreatment prevents HG (25 mM)-induced Thp1 monocyte viability...
2017: Journal of Diabetes Research
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