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Stress hyperglycemia

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https://www.readbyqxmd.com/read/29226041/dapagliflozin-cardiovascular-safety-and-benefits-in-type-2-diabetes-mellitus
#1
REVIEW
Fatima Saleem
Sodium-glucose co-transporter 2 inhibitors (SGLT2is) such as dapagliflozin, canagliflozin, and empagliflozin, are a promising new therapy in the treatment of type 2 diabetes mellitus (T2DM). SGLT2is can effectively reduce hyperglycemia thus improving glycemic control and they offer some beneficial effects on the cardiovascular (CV) system which can benefit patients with heart failure in addition toT2DM. The United States Food and Drug Administration requires new diabetes mellitus therapies to show a CV safety profile...
October 5, 2017: Curēus
https://www.readbyqxmd.com/read/29225158/exendin-4-partly-ameliorates-of-hyperglycemia-mediated-tissue-damage-in-lungs-of-streptozotocin-induced-diabetic-mice
#2
Fusun Oztay, Serap Sancar Bas, Selda Gezginci-Oktayoglu, Merve Ercin, Sehnaz Bolkent
Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion, and plays anti-inflammatory role in atherosclerosis, and has surfactant-releasing effects in lungs. GLP-1 analogues are used in diabetes therapy. This is the first study to investigate the effects of exendin-4, a GLP-1 receptor agonist, on lung injury in diabetic mice. BALB/c male mice were divided into four groups. The first group was given only citrate buffer, the second group was given only exendin-4, the third group was given only streptozotocin (STZ), and the fourth group was given both exendin-4 and STZ...
December 7, 2017: Peptides
https://www.readbyqxmd.com/read/29223856/modulation-of-glutathione-peroxidase-activity-by-age-dependent-carbonylation-in-glomeruli-of-diabetic-mice
#3
Tanja Wiedenmann, Nadine Dietrich, Thomas Fleming, Sandro Altamura, Leo E Deelman, Rob H Henning, Martina U Muckenthaler, Peter P Nawroth, Hans-Peter Hammes, Andreas H Wagner, Markus Hecker
AIMS: Low levels of reactive oxygen species and resulting oxidative protein modifications may play a beneficial role in cellular function under stress conditions. Here we studied the influence of age-dependent protein carbonylation on expression and activity of the anti-oxidative selenoenzyme glutathione peroxidase (GPx) in insulin-deficient Ins2Akita mice and type 2 diabetic obese db/db mice in context of diabetic nephropathy. METHODS: Protein carbonylation, GPx expression and activity were examined in kidney tissue and lysates by common histological and protein biochemical methods...
November 22, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29215581/stress-induced-hyperglycemia-in-diabetes-a-cross-sectional-analysis-to-explore-the-definition-based-on-the-trauma-registry-data
#4
Cheng-Shyuan Rau, Shao-Chun Wu, Yi-Chun Chen, Peng-Chen Chien, Hsiao-Yun Hsieh, Pao-Jen Kuo, Ching-Hua Hsieh
Background: The diagnosis of diabetic hyperglycemia (DH) does not preclude a diabetes patient from having a stress-induced hyperglycemic response. This study aimed to define the optimal level of elevated glucose concentration for determining the occurrence of stress-induced hyperglycemia (SIH) in patients with diabetes. Methods: This retrospective study reviewed the data of all hospitalized trauma patients, in a Level I trauma center, from 1 January 2009 to 31 December 2016. Only adult patients aged ≥20 years, with available data on serum glucose and glycated hemoglobin A1c (HbA1c) levels upon admission, were included in the study...
December 7, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29211763/hyperspectral-imaging-for-simultaneous-measurements-of-two-fret-biosensors-in-pancreatic-%C3%AE-cells
#5
Amicia D Elliott, Noah Bedard, Alessandro Ustione, Michelle A Baird, Michael W Davidson, Tomasz Tkaczyk, David W Piston
Fluorescent protein (FP) biosensors based on Förster resonance energy transfer (FRET) are commonly used to study molecular processes in living cells. There are FP-FRET biosensors for many cellular molecules, but it remains difficult to perform simultaneous measurements of multiple biosensors. The overlapping emission spectra of the commonly used FPs, including CFP/YFP and GFP/RFP make dual FRET measurements challenging. In addition, a snapshot imaging modality is required for simultaneous imaging. The Image Mapping Spectrometer (IMS) is a snapshot hyperspectral imaging system that collects high resolution spectral data and can be used to overcome these challenges...
2017: PloS One
https://www.readbyqxmd.com/read/29211033/in-vitro-and-in-vivo-antioxidant-and-anti-hyperglycemic-activities-of-moroccan-oat-cultivars
#6
Ilias Marmouzi, El Mostafa Karym, Nezha Saidi, Bouchra Meddah, Mourad Kharbach, Azlarab Masrar, Mounya Bouabdellah, Layachi Chabraoui, Khalid El Allali, Yahia Cherrah, My El Abbes Faouzi
Improvement of oat lines via introgression is an important process for food biochemical functionality. This work aims to evaluate the protective effect of phenolic compounds from hybrid Oat line (F11-5) and its parent (Amlal) on hyperglycemia-induced oxidative stress and to establish the possible mechanisms of antidiabetic activity by digestive enzyme inhibition. Eight phenolic acids were quantified in our samples including ferulic, p-hydroxybenzoic, caffeic, salicylic, syringic, sinapic, p-coumaric and chlorogenic acids...
December 6, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29207597/inhibition-of-miro1-disturbs-mitophagy-and-pancreatic-%C3%AE-cell-function-interfering-insulin-release-via-irs-akt-foxo1-in-diabetes
#7
Lingling Chen, Chunyan Liu, Jianfeng Gao, Zhiwen Xie, Lawrence W C Chan, Damien J Keating, Yibin Yang, Jiazhong Sun, Fuling Zhou, Yongchang Wei, Xiuli Men, Sijun Yang
Mitochondrial function is essential to meet metabolic demand of pancreatic beta cells respond to high nutrient stress. Mitophagy is an essential component to normal pancreatic β-cell function and has been associated with β-cell failure in Type 2 diabetes (T2D). Our previous studies have indicated that mitochondrial Rho (Miro) GTPase-mediated mitochondrial dysfunction under high nutrient stress leads to NOD-like receptor 3 (NLRP3)-dependent proinflammatory responses and subsequent insulin resistance. However, the in vivo mechanism by which Miro1 underlies mitophagy has not been identified...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29204450/the-role-of-oxidative-stress-mitochondrial-function-and-autophagy-in-diabetic-polyneuropathy
#8
REVIEW
Sonia Sifuentes-Franco, Fermín Paul Pacheco-Moisés, Adolfo Daniel Rodríguez-Carrizalez, Alejandra Guillermina Miranda-Díaz
Diabetic polyneuropathy (DPN) is the most frequent and prevalent chronic complication of diabetes mellitus (DM). The state of persistent hyperglycemia leads to an increase in the production of cytosolic and mitochondrial reactive oxygen species (ROS) and favors deregulation of the antioxidant defenses that are capable of activating diverse metabolic pathways which trigger the presence of nitro-oxidative stress (NOS) and endoplasmic reticulum stress. Hyperglycemia provokes the appearance of micro- and macrovascular complications and favors oxidative damage to the macromolecules (lipids, carbohydrates, and proteins) with an increase in products that damage the DNA...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29203148/diabetic-retinopathy-pathogenesis-and-the-ameliorating-effects-of-melatonin-involvement-of-autophagy-inflammation-and-oxidative-stress
#9
REVIEW
Ehsan Dehdashtian, Saeed Mehrzadi, Bahman Yousefi, Azam Hosseinzadeh, Russel J Reiter, Majid Safa, Habib Ghaznavi, Masood Naseripour
Diabetic retinopathy (DR), a microvascular complication of diabetes mellitus (DM), remains as one of the major causes of vision loss worldwide. The release of pro-inflammatory cytokines and the adhesion of leukocytes to retinal capillaries are initial events in DR development. Inflammation, ER stress, oxidative stress and autophagy are major causative factors involved in the pathogenesis of DR. Diabetes associated hyperglycemia leads to mitochondrial electron transport chain dysfunction culminating in a rise in ROS generation...
December 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/29199569/enzymatic-system-of-antioxidant-protection-of-erythrocytes-in-diabetic-rats-treated-with-medicinal-mushrooms-agaricus-brasiliensis-and-ganoderma-lucidum-agaricomycetes
#10
Taras Y Vitak, Solomon P Wasser, Eviatar Nevo, Nataliya O Sybirna
Excessive glucose concentrations in blood and cells promote the intensification of auto-oxidation. This is one of the mechanisms through which free radicals form in hyperglycemia. As a result of hyperglycemia, oxidative stress develops and lipid peroxidation (LPO) is enhanced. Erythrocytes are particularly susceptible to reactive oxygen species and LPO, which can violate cell functions. This article describes the analysis of the influence of mycelia from the medicinal mushrooms Agaricus brasiliensis and Ganoderma lucidum on the enzymatic link of the antioxidant system in rat erythrocytes under streptozotocin-induced diabetes mellitus...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29195627/ethyl-pyruvate-is-renoprotective-against-ischemia-reperfusion-injury-under-hyperglycemia
#11
Ji Hae Jun, Jong Wook Song, Eun-Jung Shin, Young-Lan Kwak, Nakcheol Choi, Jae-Kwang Shim
BACKGROUND: Hyperglycemia (HG) is common in cardiovascular surgeries due to diabetes, inflammation, and the neuroendocrine stress response. HG aggravates renal ischemia-reperfusion (I/R) injury through an increased inflammatory response, and blunts the protective effect of various measures. Ethyl pyruvate (EP) provides anti-inflammatory effects against I/R injury via inhibition of high-mobility group box 1 protein (HMGB1) release. This study aimed to determine the renoprotective effect of EP against I/R injury under HG...
November 1, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29183105/relation-of-carotid-artery-plaque-to-coronary-heart-disease-and-stroke-in-chinese-patients-does-hyperglycemia-status-matter
#12
Huanhuan Zhou, Xiaoyun Wang, Junya Zhu, Anne Fish, Weimin Kong, Fan Li, Lin Liu, Xiaodan Yuan, Xin Gao, Qingqing Lou
Objective To examine the association of carotid artery plaque with the incident coronary heart disease and stroke events in Chinese patients and explore whether the association differs between patients with and without hyperglycemia. Methods We evaluated plaque, and blood pressure, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting serum insulin, fasting plasma glucose, 2 h postprandial glucose and Homeostasis model assessment of insulin resistance in 253 Chinese patients...
November 28, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29181156/proteomic-profile-of-the-lens-in-a-streptozotocin-induced-diabetic-rat-model-using-shotgun-proteomics
#13
Noriaki Nagai, Tetsushi Yamamoto, Kuniko Mitamura, Atsushi Taga
Streptozotocin (STZ)-induced diabetic rats (STZ rats) were used to investigate diabetic cataracts. In the current study, a shotgun liquid chromatography (LC)/mass spectrometry (MS)-based global proteomic analysis method was used to examine the mechanism of lens opacification as a result of hyperglycemia in STZ rats. The 6-week old Wistar rats were injected with STZ for 2 days (100 mg/kg/day, i.p.) and housed for 3 weeks. The plasma glucose levels were identified to be significantly higher when compared with the normal rats and insulin was not detected in the STZ rats...
November 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29180887/ingested-capsaicinoids-can-prevent-low-fat-high-carbohydrate-diet-and-high-fat-diet-induced-obesity-by-regulating-the-nadph-oxidase-and-nrf2-pathways
#14
Kazim Sahin, Cemal Orhan, Mehmet Tuzcu, Nurhan Sahin, Oguzhan Ozdemir, Vijaya Juturu
Objective: Capsaicinoids (CAPs), most commonly found in chili peppers, have a multitude of pharmacological and physiological effects, such as anti-inflammation, antioxidant, and anticancer effects. In the present study, we set out to investigate the hypothesis that CAPs mitigate obesity in rats and the possible mechanisms thereof. Materials and methods: Rats were divided into six groups, including control (±10 mg CAPs/kg body weight [BW]), low-fat-high-sucrose diet (±10 mg CAPs/kg BW), and high-fat diet (±10 mg CAPs/kg BW)...
2017: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29178342/microrna-145-regulates-disabled-2-and-wnt3a-expression-in-cardiomyocytes-under-hyperglycemia
#15
Bao-Wei Wang, Wei-Jen Fang, Kou-Gi Shyu
AIMS: MicroRNA-145 (miR-145) could protect cardiomyocyte apoptosis against oxidative stress and repair infarcted myocardium. Angiotensin II (Ang II), a pro-inflammatory cytokine could modulate myocardial remodeling. However, the role of hyperglycemia on miR-145 expression in cardiomyocyte or diabetes is not known. The effect of Ang II on miR-145 expression under hyperglycemia in cardiomyocytes remains unknown. We sought to investigate the effect of hyperglycemia and Ang II on miR-145 expression in cardiomyocytes...
November 25, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29174036/increase-in-renal-erythropoietin-receptors-in-diabetic-rats-is-mainly-mediated-by-hyperglycemia-associated-with-the-stat3-gata-1-signaling-pathway
#16
Shu-Chun Kuo, Yingxiao Li, Kai-Chun Cheng, Chiang-Shan Niu, Juei-Tang Cheng, Ho-Shan Niu
Erythropoietin (EPO) produces cytoprotection in many tissues by activating the EPO receptor (EPOR); these effects include anti-oxidative stress and the inhibition of apoptosis in renal tubular cells. Moreover, EPO is clinically used in diabetic patients who suffer from chronic renal disease. However, the effect of hyperglycemia on renal EPOR expression remains unknown. Therefore, we determined the changes in renal EPOR expression in diabetic rats and investigated the role of potential factors using cultured cells...
November 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29172149/exposure-to-deltamethrin-induces-oxidative-stress-and-decreases-of-energy-reserve-in-tissues-of-the-neotropical-fruit-eating-bat-artibeus-lituratus
#17
Jerusa Maria Oliveira, Nicole Fontes Losano, Suellen Silva Condessa, Renata Maria Pereira de Freitas, Silvia Almeida Cardoso, Mariella Bontempo Freitas, Leandro Licursi de Oliveira
Deltamethrin (DTM) is a synthetic pyrethroid insecticide highly used by farmers and home users. This pesticide has lipophilic properties that facilitate a high absorption and can cause toxicity in non-target organisms. During foraging, the fruit-eating bats Artibeus lituratus are exposed to pesticides. However, the knowledge of the toxicity of pesticides on the physiology of bats is relatively scarce. This study aimed to check the toxicity of short-term exposure to low concentration of DTM on fruit-eating bat A...
November 21, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29166383/prematurity-disrupts-glomeruli-development-while-prematurity-and-hyperglycemia-lead-to-altered-nephron-maturation-and-increased-oxidative-stress-in-newborn-baboons
#18
Danielle A Callaway, Lisa L McGill-Vargas, Amy Quinn, Jasmine L Jordan, Lauryn A Winter, Diana Anzueto, Edward J Dick, Cynthia L Blanco
BACKGROUND: Premature birth occurs when nephrogenesis is incomplete and has been linked to increased renal pathologies in the adult. Metabolic factors complicating preterm birth may have additional consequences for kidney development. Here, we evaluated the effects of prematurity and hyperglycemia on nephrogenesis in premature baboons when compared to term animals. METHODS: Baboons were delivered prematurely (67% gestation; n=9) or at term (n=7) and survived 2-4 weeks...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29164127/antidiabetic-effects-of-aronia-melanocarpa-and-its-other-therapeutic-properties
#19
REVIEW
Ines Banjari, Andreja Misir, Katarina Šavikin, Stela Jokić, Maja Molnar, H K S De Zoysa, Viduranga Y Waisundara
Diabetes is a global pandemic which warrants urgent attention due to its rising prevalence and economic burden. Thus, many alternative therapies are being researched for antidiabetic properties, given the inefficacy of current medicinal treatments. From this perspective, Aronia melanocarpa or black chokeberry has been investigated for its therapeutic properties in many studies, especially for its ability to combat hyperglycemia-induced oxidative stress and the macrovascular complications of diabetes including cardiovascular disease...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/29163755/uncoupling-protein-2-a-key-player-and-a-potential-therapeutic-target-in-vascular-diseases
#20
REVIEW
Giorgia Pierelli, Rosita Stanzione, Maurizio Forte, Serena Migliarino, Marika Perelli, Massimo Volpe, Speranza Rubattu
Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein that belongs to the uncoupling protein family and plays an important role in lowering mitochondrial membrane potential and dissipating metabolic energy with prevention of oxidative stress accumulation. In the present article, we will review the evidence that UCP2, as a consequence of its roles within the mitochondria, represents a critical player in the predisposition to vascular disease development in both animal models and in humans, particularly in relation to obesity, diabetes, and hypertension...
2017: Oxidative Medicine and Cellular Longevity
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