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Stress hyperglycemia

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https://www.readbyqxmd.com/read/29679925/tocotrienol-rich-fraction-supplementation-reduces-hyperglycemia-induced-skeletal-muscle-damage-through-regulation-of-insulin-signaling-and-oxidative-stress-in-type-2-diabetic-mice
#1
Heaji Lee, Yunsook Lim
Chronic hyperglycemia induces impairment of muscle growth and development of diabetes mellitus (DM). Since skeletal muscle is the major site for disposal of ingested glucose, impaired glucose metabolism causes imbalance between protein synthesis and degradation which adversely affects physical mobility. In this study, we investigated the effect of tocotrienol-rich fraction (TRF) supplementation on skeletal muscle damage in diabetic mice. Diabetes was induced by a high-fat diet with streptozotocin (STZ) injection (100 mg/kg) in male C57BL/6J mice...
March 21, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29679627/diabetes-and-cancer-pathophysiological-fundamentals-of-a-dangerous-affair
#2
REVIEW
Angelo Cignarelli, Valentina Annamaria Genchi, Irene Caruso, Annalisa Natalicchio, Sebastio Perrini, Luigi Laviola, Francesco Giorgino
Diabetes and cancer are worldwide chronic diseases with a major impact on the quality and expectancy of life. Metabolic abnormalities observed during the onset and progression of diabetes may have a critical role on the initiation and progression of carcinogenesis. To date, there are no conclusive data on the mechanisms underlying the relationship between diabetes and any type of human cancer. However, recent evidence suggests that both hyperglycemia and hyperinsulinemia in diabetes could elicit cell damage responses, such as glucotoxicity, lipotoxicity and oxidative stress, which participate in the cell transformation process raising the risk of cancer development...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29678824/metabolic-karma-the-atherogenic-legacy-of-diabetes-the-2017-edwin-bierman-award-lecture
#3
Mark Emmanuel Cooper, Assam El-Osta, Terri Jean Allen, Anna Margareta Dorothea Watson, Merlin Christopher Thomas, Karin Agnes Maria Jandeleit-Dahm
Cardiovascular disease, despite all the recent advances in treatment of the various risk factors, remains the major cause of mortality in both type 1 and type 2 diabetes. Experimental models of diabetes-associated atherosclerosis, despite their limitations in recapitulating the human context, have assisted in the elucidation of molecular and cellular pathways implicated in the development and progression of macrovascular injury in diabetes. Our own studies have emphasized the role of oxidative stress and advanced glycation and identified potential targets for vasoprotective therapies in the setting of diabetes...
May 2018: Diabetes
https://www.readbyqxmd.com/read/29677453/l-carnitine-induced-amelioration-of-hdf-induced-hepatic-dysfunction-is-accompanied-by-a-reduction-in-hepatic-tnf-%C3%AE-and-tgf%C3%AE-1
#4
Mabrouk Attia Abd Eldaim, Fatma Mohamed Ibrahim, Sahar H Orabi, Azza Hassan Morsi, Hesham Saad ElSabbagh
In this study the possible mechanisms through which L-carnitine ameliorates the adverse effects of high fat diet (HFD) induced obesity on rats was evaluated. 56 Wister albino rats were randomly assigned into seven groups. Control rats fed basal diet. 2nd group fed basal diet and injected with L-carnitine 200 mg/kg i.p. 3rd group fed HFD. 4th group fed HFD and injected with L-Carnitine 200 mg/kg i.p for 8 weeks. 5th group fed HFD for 10 weeks. 6th group fed HFD for 10 weeks and injected with L-Carnitine 200 mg/kg i...
April 20, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29675553/a-potential-strategy-for-treating-atherosclerosis-improving-endothelial-function-via-amp-activated-protein-kinase
#5
REVIEW
Feng Gao, Jiemei Chen, Haibo Zhu
Endothelial dysfunction is caused by many factors, such as dyslipidemia, endoplasmic reticulum (ER) stress, and inflammation. It has been demonstrated that endothelial dysfunction is the initial process of atherosclerosis. AMP-activated protein kinase (AMPK) is an important metabolic switch that plays a crucial role in lipid metabolism and inflammation. However, recent evidence indicates that AMPK could be a target for atherosclerosis by improving endothelial function. For instance, activation of AMPK inhibits the production of reactive oxygen species induced by mitochondrial dysfunction, ER stress, and NADPH oxidase...
April 16, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29670899/guava-leaf-extract-diminishes-hyperglycemia-and-oxidative-stress-prevents-%C3%AE-cell-death-inhibits-inflammation-and-regulates-nf-kb-signaling-pathway-in-stz-induced-diabetic-rats
#6
Muthukumaran Jayachandran, Ramachandran Vinayagam, Ranga Rao Ambati, Baojun Xu, Stephen Sum Man Chung
Traditional Chinese medication has been utilized by Chinese medical practitioners to treat the varied symptoms of diabetes mellitus (DM). Notably, guava leaf has been used to treat diabetes in Asia. Our present study has been designed to analyze the action of guava leaf extract (GLE) at the molecular level in treating DM. A low dose of streptozotocin (STZ) was used to induce experimental diabetes in animals. Rats were treated with GLE at different concentrations (100, 200, and 400 mg/kg b.w.). The standard drug glibenclamide (GB) (600  μ g/kg b...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29667441/long-term-consumption-of-western-diet-contributes-to-endothelial-dysfunction-and-aortic-remodeling-in-rats-implication-of-rho-kinase-signaling
#7
Rania A Elrashidy, Jing Zhang, Guiming Liu
Western diet (WD), rich in saturated fat and sugars, has become a risk factor for obesity and metabolic syndrome, however, its effect on endothelial function and vascular remodeling is not fully elucidated. Recent evidence suggests cross-talk between Rho kinase (ROCK) pathway and cardiovascular system. We aimed to investigate the effect of WD on aortic remodeling and the contribution of ROCK signaling. Eight week old male Sprague-Dawley rats were fed either standard chow diet (SD) or high fructose/ high-fat diet, typically as in WD...
April 18, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29661782/doc2b-protects-%C3%AE-cells-against-inflammatory-damage-and-enhances-function
#8
Arianne Aslamy, Eunjin Oh, Erika M Olson, Jing Zhang, Miwon Ahn, Abu Saleh Md Moin, Ragadeepthi Tunduguru, Vishal A Salunkhe, Rajakrishnan Veluthakal, Debbie C Thurmond
Loss of functional β-cell mass is an early feature of type 1 diabetes. To release insulin, β-cells require soluble n-ethylmaleimide-sensitive factor-attachment protein receptor (SNARE) complexes, as well as SNARE complex regulatory proteins like Double C2-domain protein β (DOC2B). We hypothesized that DOC2B deficiency or overabundance may confer susceptibility or protection, respectively, to the functional β-cell mass. Indeed, Doc2b +/- knockout mice show an unusually severe response to multiple-low-dose streptozotocin (MLD-STZ), resulting in more apoptotic β-cells and a smaller β-cell mass...
April 16, 2018: Diabetes
https://www.readbyqxmd.com/read/29661504/stress-induced-hyperglycemia-on-complications-in-non-critically-elderly-hospitalized-patients
#9
F J Carrasco-Sánchez, J Carretero-Gómez, R Gómez-Huelgas, M A Garcia-Ordoñez, M V Pardo-Ortega, B de Escalante-Yanguela, L Mateos-Polo, F Formiga, J Ena
AIMS: Hospital complications and hyperglycemia are common in elderly patients during hospitalization. Our aim was to analyze the relationship between hyperglycemia and hospital complications in an ageing population. METHODS: We conducted an observational study to evaluate the association between maximum blood glucose (MBG) levels and hospital complications. Patients were stratified according to the quartiles of MBG levels. Diabetes mellitus (DM) was determined by patient history and/or admission glycated hemoglobin (HbA1c) level ≥6...
April 13, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29661114/pasireotide-treatment-does-not-modify-hyperglycemic-and-corticosterone-acute-restraint-stress-responses-in-rats
#10
Antônio Ribeiro-Oliveira, Junia R O L Schweizer, Pedro H S Amaral, Mariana F Bizzi, Warley Cezar da Silveira, Daniel T A Espirito-Santo, Giancarlo Zille, Beatriz S Soares, Herbert A Schmid, Kevin C J Yuen
Pasireotide is a new-generation somatostatin analog that acts through binding to multiple somatostatin receptor subtypes. Studies have shown that pasireotide induces hyperglycemia, reduces glucocorticoid secretion, alters neurotransmission, and potentially affects stress responses typically manifested as hyperglycemia and increased corticosterone secretion. This study specifically aimed to evaluate whether pasireotide treatment modifies glucose and costicosterone secretion in response to acute restraint stress...
April 17, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29658605/aerobic-exercise-regulates-blood-lipid-and-insulin-resistance-via-the-toll%C3%A2-like-receptor-4%C3%A2-mediated-extracellular-signal%C3%A2-regulated-kinases-amp%C3%A2-activated-protein-kinases-signaling-pathway
#11
Mei Wang, Sen Li, Fubaihui Wang, Jinhui Zou, Yanfeng Zhang
Diabetes mellitus is a complicated metabolic disease with symptoms of hyperglycemia, insulin resistance, chronic damage and dysfunction of tissues, and metabolic syndrome for insufficient insulin production. Evidence has indicated that exercise treatments are essential in the progression of type‑ІІ diabetes mellitus, and affect insulin resistance and activity of islet β‑cells. In the present study, the efficacy and signaling mechanism of aerobic exercise on blood lipids and insulin resistance were investigated in the progression of type‑ІІ diabetes mellitus...
April 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29655866/activation-of-gsk3%C3%AE-%C3%AE-trcp-axis-via-phlpp1-exacerbates-nrf2-degradation-leading-to-impairment-in-cell-survival-pathway-during-diabetic-nephropathy
#12
Alpana Mathur, Vivek Kumar Pandey, Poonam Kakkar
NF-E2 p45-related factor 2 (Nrf2), is a major redox sensitive transcription factor that plays an essential role in regulating glucose metabolism. Inactivation of Nrf2 has been associated with diabetic complications however, mechanisms warranting Nrf2 suppression are incompletely understood. We hypothesized that PHLPP1 activates GSK3β to induce β-TrCP mediated Nrf2 phosphorylation and degradation. In vivo study was carried out in STZ-NA induced type 2 diabetic male Wistar rats. GSK3β mediated Nrf2 ubiquitination was confirmed by administration of GSK3β inhibitor (LiCl; 60mg/kg bwt...
April 12, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29651204/ameliorative-effects-of-allium-sativum-extract-on-inos-gene-expression-and-no-production-in-liver-of-streptozotocin-nicotinamide-induced-diabetic-rats
#13
Nasrin Ziamajidi, Hamid Behrouj, Roghayeh Abbasalipourkabir, Fatemeh Lotfi
Diabetes mellitus (DM) is one of the most prevalent diseases in the world, which is strongly associated with liver dysfunction. Hyperglycemia, through an oxidative stress pathway, damages various tissues. Herbal medicine is a good candidate to ameliorate hyperglycemia and oxidative stress. In this study, the effects of aqueous Allium sativum (garlic) extract (AGE) on gene expression of inducible nitric oxide synthases (iNOS) and production of nitric oxide (NO) were evaluated in the liver tissue of diabetic rats...
April 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29649637/angiogenesis-impairment-by-the-nadph-oxidase-triggered-oxidative-stress-at-the-bone-implant-interface-critical-mechanisms-and-therapeutic-targets-for-implant-failure-under-hyperglycemic-conditions-in-diabetes
#14
Xiao-Fan Hu, Lin Wang, Geng Xiang, Wei Lei, Ya-Fei Feng
Mechanism underlying the diabetes-induced poor osteointegration of implants remains elusive, making it a challenge to develop corresponding solutions. Here, we studied the role of angiogenesis in the diabetes-induced poor bone repair at the bone-implant interface (BII) and the related mechanisms. In vivo, titanium screws were implanted in the femurs of mice, and, in vitro, vascular endothelial cell (VEC) was cultured on titanium surface. Results showed that, compared with normal milieu (NM), diabetic milieu (DM) led to angiogenesis inhibition around implants which resulted in reduced osteoprogenitors and poor bone formation on BII in vivo...
April 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29643979/cardiac-autonomic-neuropathy-as-a-result-of-mild-hypercaloric-challenge-in-absence-of-signs-of-diabetes-modulation-by-antidiabetic-drugs
#15
Ola Al-Assi, Rana Ghali, Ali Mroueh, Abdullah Kaplan, Nahed Mougharbil, Ali H Eid, Fouad A Zouein, Ahmed F El-Yazbi
Cardiac autonomic neuropathy (CAN) is an early cardiovascular complication of diabetes occurring before metabolic derangement is evident. The cause of CAN remains elusive and cannot be directly linked to hyperglycemia. Recent clinical data report cardioprotective effects of some antidiabetic drugs independent of their hypoglycemic action. Here, we used a rat model receiving limited daily increase in calories from fat (HC diet) to assess whether mild metabolic challenge led to CAN in absence of interfering effects of hyperglycemia, glucose intolerance, or obesity...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29643115/chronic-at1-blockade-improves-glucose-homeostasis-in-obese-oletf-rats
#16
Ruben Rodriguez, Jacqueline N Minas, Jose Pablo Vazquez-Medina, Daisuke Nakano, David G Parkes, A Nishiyama, Rudy M Ortiz
Obesity is associated with the inappropriate activation of the renin-angiotensin-system (RAS), which increases arterial pressure, impairs insulin secretion, and decreases peripheral tissue insulin sensitivity. RAS blockade reverses these detriments; however, it is not clear whether the disease state of the organism and treatment duration determine the beneficial effects of RAS inhibition on insulin secretion and insulin sensitivity. Therefore, the objective of this study was to compare the benefits of acute vs...
April 11, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29629372/glomerular-endothelial-cells-stress-and-cross-talk-with-podocytes-in-the-development-of-diabetic-kidney-disease
#17
REVIEW
Ilse Sofia Daehn
Diabetic kidney disease (DKD) is one of the major causes of morbidity and mortality in diabetic patients and also the leading single cause of end-stage renal disease in the United States. A large proportion of diabetic patients develop DKD and others don't, even with comparable blood glucose levels, indicating a significant genetic component of disease susceptibility. The glomerulus is the primary site of diabetic injury in the kidney, glomerular hypertrophy and podocyte depletion are glomerular hallmarks of progressive DKD, and the degree of podocyte loss correlates with severity of the disease...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29626150/rac1-modulates-endothelial-function-and-platelet-aggregation-in-diabetes-mellitus
#18
Gabriele Giacomo Schiattarella, Albino Carrizzo, Federica Ilardi, Antonio Damato, Mariateresa Ambrosio, Michele Madonna, Valentina Trimarco, Marina Marino, Elena De Angelis, Silvio Settembrini, Cinzia Perrino, Bruno Trimarco, Giovanni Esposito, Carmine Vecchione
BACKGROUND: Vascular complications and abnormal platelet function contribute to morbidity and mortality in diabetes mellitus. We hypothesized that the Rho-related GTPase protein, Rac1, can influence both endothelial and platelet function and might represent a potential novel therapeutic target in diabetes mellitus. METHODS AND RESULTS: We used both in vitro and ex vivo approaches to test the effects of pharmacological inhibition of Rac1 during hyperglycemic condition...
April 6, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29623672/a-systematic-review-on-the-protective-effect-of-n-acetyl-cysteine-against-diabetes-associated-cardiovascular-complications
#19
REVIEW
Phiwayinkosi V Dludla, Stephanie C Dias, Nnini Obonye, Rabia Johnson, Johan Louw, Bongani B Nkambule
INTRODUCTION: Heart failure is the leading cause of death in patients with diabetes. No treatment currently exists to specifically protect these patients at risk of developing cardiovascular complications. Accelerated oxidative stress-induced tissue damage due to persistent hyperglycemia is one of the major factors implicated in deteriorated cardiac function within a diabetic state. N-acetyl cysteine (NAC), through its enhanced capacity to endogenously synthesize glutathione, a potent antioxidant, has displayed abundant health-promoting properties and has a favorable safety profile...
April 6, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29617268/antidiabetic-and-renoprotective-effect-of-anogeissus-acuminata-leaf-extract-on-experimentally-induced-diabetic-nephropathy
#20
Archana M Navale, Archana Paranjape
BACKGROUND: Diabetic nephropathy is the leading cause of end-stage renal disease. Hyperglycemia, oxidative stress, and inflammation are some of the mechanisms involved in renal damage. Anogeissus acuminata (AA) is used in India as an antidiabetic agent and has potent antioxidant activity. However, it has never been evaluated for its effect on diabetic nephropathy. Hence, in the present study we aimed to evaluate its effect on streptozotocin-induced diabetes mellitus and its renal complications...
April 4, 2018: Journal of Basic and Clinical Physiology and Pharmacology
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