keyword
MENU ▼
Read by QxMD icon Read
search

Locked in

keyword
https://www.readbyqxmd.com/read/29150814/detecting-multiple-random-changepoints-in-bayesian-piecewise-growth-mixture-models
#1
Eric F Lock, Nidhi Kohli, Maitreyee Bose
Piecewise growth mixture models are a flexible and useful class of methods for analyzing segmented trends in individual growth trajectory over time, where the individuals come from a mixture of two or more latent classes. These models allow each segment of the overall developmental process within each class to have a different functional form; examples include two linear phases of growth, or a quadratic phase followed by a linear phase. The changepoint (knot) is the time of transition from one developmental phase (segment) to another...
November 17, 2017: Psychometrika
https://www.readbyqxmd.com/read/29150632/mucoadhesive-functionality-of-cell-wall-structures-from-fruits-and-grains-electrostatic-and-polymer-network-interactions-mediated-by-soluble-dietary-polysaccharides
#2
Oliver W Meldrum, Gleb E Yakubov, Ghanendra Gartaula, Michael A McGuckin, Michael J Gidley
We demonstrate the enhancement of intestinal mucin (Muc2) binding to plant cell wall structures from fruit (parenchymal apple tissue) and grain (wheat endosperm) mediated by soluble dietary fibers embedded within cellulose networks. Mucin binding occurs through two distinct mechanisms; for pectin polysaccharides characteristic of fruits and vegetables, it is governed by molecular mucoadhesive interactions, while for neutral polysaccharides, arabinoxylan and β-glucan characteristic of cereal grains, the interaction stems from the properties of their polymer network...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29150380/comparison-of-two-physiotherapy-programmes-for-rehabilitation-after-temporomandibular-joint-arthroscopy
#3
W A Abboud, N Yarom, R Yahalom, M Joachim, S Reiter, O Koren, H Elishoov
The purpose of this study was to compare two physiotherapy programmes for rehabilitation after temporomandibular joint (TMJ) arthroscopy. The medical files of 137 consecutive patients diagnosed with closed lock and treated by arthroscopic lysis and lavage were analyzed retrospectively. Sixty-eight patients were rehabilitated with gradually increasing range of motion self-exercises (gradual programme) and 69 patients were rehabilitated with immediate full range of motion self-exercises (immediate programme)...
November 14, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29150249/accuracy-of-the-cobas-egfr-mutation-assay-in-non-small-cell-lung-cancer-compared-with-three-laboratory-developed-tests
#4
Haruhiko Nakamura, Hirotaka Koizumi, Hiroki Sakai, Hiroyuki Kimura, Tomoyuki Miyazawa, Hideki Marushima, Hisashi Saji, Masayuki Takagi
BACKGROUND: The reliability of the cobas EGFR assay to detect epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancer (NSCLC) as an in vitro diagnostic test was compared with 3 laboratory-developed tests (LDTs). MATERIALS AND METHODS: After screening for EGFR mutations using formalin-fixed-paraffin-embedded NSCLC tissue sections using the cobas EGFR assay, 151 samples were further tested with 3 LDTs; the peptide nucleic acid-locked nucleic acid polymerase chain reaction (PCR) clamp, PCR invader, and Cycleave assays...
October 28, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29150151/evaluating-short-and-long-term-impacts-of-a-medicaid-lock-in-program-on-opioid-and-benzodiazepine-prescriptions-dispensed-to-beneficiaries
#5
Rebecca B Naumann, Stephen W Marshall, Jennifer L Lund, Nisha C Gottfredson, Christopher L Ringwalt, Asheley C Skinner
BACKGROUND: Insurance-based "lock-in" programs (LIPs) have become a popular strategy to address controlled substance (CS) (e.g., opioid) misuse. However, little is known about their impacts. We examined changes in CS dispensing to beneficiaries in the 12-month North Carolina Medicaid LIP. METHODS: We analyzed Medicaid claims linked to Prescription Drug Monitoring Program (PDMP) records for beneficiaries enrolled in the LIP between October 2010 and September 2012 (n=2702)...
November 6, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29149628/multiplex-taqman-locked-nucleic-acid-real-time-pcr-for-the-differential-identification-of-various-meat-and-meat-products
#6
Rusu Xu, Shuang Wei, Guangbiao Zhou, Jiao Ren, Zhongyong Liu, Shuze Tang, Peter C K Cheung, Xiyang Wu
Meat adulteration incidents have been reported frequently over the past few years, and the corresponding traceability issues attracted much more attention due to the customer's demands and administration's responsibility. Therefore, it is important to develop high-throughput and rapid detection methods to identify the specific sources from meat samples. In this study, a multiplex TaqMan locked nucleic acid real-time polymerase chain reaction assay (MLNA-RT-PCR) was developed to simultaneously detect multiple meat sources (duck, pork, beef and chicken)...
November 14, 2017: Meat Science
https://www.readbyqxmd.com/read/29148825/on-the-growth-and-detectability-of-land-plants-on-habitable-planets-around-m-dwarfs
#7
Duo Cui, Feng Tian, Yuwei Wang, Changshen Li, Chaoqing Yu, Le Yu
One signature of life on Earth is the vegetation red edge (VRE) feature of land plants, a dramatic change of reflectivity at wavelength near 0.7 μm. Potentially habitable planets around M dwarfs are tidally locked, which can limit the distribution of land plants. In this study, we used a biogeochemical model to investigate the distribution of land plants on potentially habitable planets around M dwarfs driven by climate data produced in a general circulation model (GCM). When considering the effects of clouds, the observation time needed for VRE detection on nearby p = 1 exoplanets around nearby M dwarfs is on the order of days using a 25 m(2) telescope if a large continent faces Earth during observations...
November 17, 2017: Astrobiology
https://www.readbyqxmd.com/read/29148819/unveiling-structural-motions-of-a-highly-fluorescent-superphotoacid-by-locking-and-fluorinating-the-gfp-chromophore-in-solution
#8
Cheng Chen, Weimin Liu, Mikhail S Baranov, Nadezhda S Baleeva, Ilia V Yampolsky, Liangdong Zhu, Yanli Wang, Alexandra Shamir, Kyril M Solntsev, Chong Fang
Super-photoacidity involves ultrafast proton motions implicated in numerous chemical and biological processes. We used conformational locking and strategic addition of electron-withdrawing substituents to synthesize a new GFP-chromophore analog: p-HO-3,5-diF-BDI:BF2 (diF). It is highly fluorescent and exhibits excited-state proton transfer (ESPT) in various solvents, placing it among the strongest photoacids. Tunable femtosecond stimulated Raman spectroscopy with unique resonance conditions and transient absorption are complementarily employed to elucidate structural basis for super-photoacidity...
November 17, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29147142/analysis-of-functional-brain-connections-for-positive-negative-emotions-using-phase-locking-value
#9
Yasar Dasdemir, Esen Yildirim, Serdar Yildirim
In this study, we investigate the brain networks during positive and negative emotions for different types of stimulus (audio only, video only and audio + video) in [Formula: see text], and [Formula: see text] bands in terms of phase locking value, a nonlinear method to study functional connectivity. Results show notable hemispheric lateralization as phase synchronization values between channels are significant and high in right hemisphere for all emotions. Left frontal electrodes are also found to have control over emotion in terms of functional connectivity...
December 2017: Cognitive Neurodynamics
https://www.readbyqxmd.com/read/29146907/giant-magnetic-splitting-inducing-near-unity-valley-polarization-in-van-der-waals-heterostructures
#10
Philipp Nagler, Mariana V Ballottin, Anatolie A Mitioglu, Fabian Mooshammer, Nicola Paradiso, Christoph Strunk, Rupert Huber, Alexey Chernikov, Peter C M Christianen, Christian Schüller, Tobias Korn
Monolayers of semiconducting transition metal dichalcogenides exhibit intriguing fundamental physics of strongly coupled spin and valley degrees of freedom for charge carriers. While the possibility of exploiting these properties for information processing stimulated concerted research activities towards the concept of valleytronics, maintaining control over spin-valley polarization proved challenging in individual monolayers. A promising alternative route explores type II band alignment in artificial van der Waals heterostructures...
November 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29146594/heterologous-phosphorylation-induced-formation-of-a-stability-lock-permits-regulation-of-inactive-receptors-by-%C3%AE-arrestins
#11
András D Tóth, Susanne Prokop, Pál Gyombolai, Péter Várnai, András Balla, Vsevolod V Gurevich, László Hunyady, Gábor Turu
β-arrestins are key regulators and signal transducers of G protein-coupled receptors (GPCRs). The interaction between receptors and β-arrestins is generally believed to require both receptor activity and phosphorylation by GPCR kinases. In this study, we investigated whether β-arrestins are able to bind second messenger kinase-phosphorylated, but inactive receptors as well. Since heterologous phosphorylation is a common phenomenon among GPCRs, this mode of β-arrestin activation may represent a novel mechanism of signal transduction and receptor cross-talk...
November 16, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29145970/minimally-invasive-posteromedial-percutaneous-plate-osteosynthesis-for-diaphyseal-tibial-fractures-technique-description
#12
Andre Wajnsztejn, Robinson Esteves Santos Pires, Alexandre Leme Godoy Dos Santos, Pedro Jose Labronici, Helio Jorge Alvachian Fernandes, Mario Ferretti
PURPOSE: The aim of this study was to evaluate the feasibility of performing minimally-invasive plate osteosynthesis (MIPO) in tibial fractures using two posteromedial incisions, and to measure the distance between the plate and neurovascular structures. MATERIALS AND METHODS: We performed nine dissections of specimens that were submitted to tibial MIPO with two posteromedial incisions. One locking compression plate (LCP) of 14 to 16 holes was inserted into the submuscular tunnel in a retrograde manner...
October 2017: Injury
https://www.readbyqxmd.com/read/29145967/bone-intramedullary-reaming-grafts-the-fracture-site-with-cd146-skeletal-progenitors-and-downmodulates-the-inflammatory-environment
#13
Leonardo R Rocha, Rafaela C Sartore, Ana C Leal, Rhayra B Dias, Maria Eugenia L Duarte, João Antônio M Guimarães, Danielle C Bonfim
INTRODUCTION: Femoral shaft fractures generally occur in young adults following a high-energy trauma and are prone to delayed union/non-union. Novel therapies to stimulate bone regeneration will have to mimic some of the aspects of the biology of fracture healing; however, which are these aspects is unclear. Locked intramedullary nailing is the current treatment of choice for the stabilisation of femur shaft fractures, and it is associated with accelerated healing and increased union rates...
October 2017: Injury
https://www.readbyqxmd.com/read/29145966/outcome-evaluation-of-staged-treatment-for-bicondylar-tibial-plateau-fractures
#14
Vincenzo Giordano, Ney Pecegueiro do Amaral, Hilton A Koch, Rodrigo Pires E Albuquerque, Felipe Serrão de Souza, José Félix Dos Santos Neto
BACKGROUND: The universal accepted strategy for treating high-energy tibial plateau fractures remains a topic of ongoing debate. The challenge for the practicing orthopaedic trauma surgeon is to provide anatomical articular fracture reduction, with successfully managing the complex soft-tissue injury that is commonly present at patient admission. The primary aim of the actual study was to evaluate the results of a staged protocol for the treatment of high-energy bicondylar tibial plateau fractures...
October 2017: Injury
https://www.readbyqxmd.com/read/29145351/comparison-of-treatment-of-acute-unstable-distal-clavicle-fractures-using-anatomical-locking-plates-with-versus-without-additional-suture-anchor-fixation
#15
Jixing Fan, Yufu Zhang, Qiang Huang, Xieyuan Jiang, Liang He
BACKGROUND Surgical managements were recommended for unstable distal clavicle fracture owing to the high incidence of nonunion. The present study compared the efficacy of anatomical locking plate with versus without additional suture anchor fixation for the treatment of unstable Neer type II distal clavicle fractures. MATERIAL AND METHODS Between January 2013 to January 2015, 28 consecutive patients with unstable Neer type II  fractures were treated by using anatomical locking plate with or without additional suture anchor fixation...
November 16, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29145343/anterior-release-and-nonstructural-bone-grafting-and-posterior-fixation-for-old-lower-cervical-dislocations-with-locked-facets
#16
Chen Ding, Ting-Kui Wu, Quan Gong, Tao Li, Li-Tai Ma, Bei-Yu Wang, Yu-Xiao Deng, Hao Liu
Lower cervical dislocations are often missed at the time of initial injury for several reasons. The treatment of old facet dislocations of the lower cervical spine is difficult, and the optimal method has not been established. The objective of the present study was to evaluate the clinical outcomes of a surgical technique, anterior release, and nonstructural bone grafting combined with posterior fixation, for the treatment of old lower cervical dislocations with locked facets.This was a retrospective study of 17 patients (13 men and 4 women) with old facet dislocations, who underwent the same surgical treatment at our hospital between April 2010 and January 2016...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144584/3d-printed-anchoring-sutures-for-permanent-shaping-of-tissues
#17
Wei Wei, Yuxiao Li, Huazhe Yang, Reza Nassab, Fatemeh Shahriyari, Ali Akpek, Xiaofei Guan, Yanhui Liu, Shahrouz Taranejoo, Ali Tamayol, Yu Shrike Zhang, Ali Khademhosseini, Hae Lin Jang
Sutures are one of the most widely used devices for adhering separated tissues after injury or surgery. However, most sutures require knotting, which can create a risk of inflammation, and can act as mechanically weak points that often result in breakage and slipping. Here, an anchoring suture is presented with a design that facilitates its propagation parallel to the suturing direction, while maximizing its resistive force against the opposite direction of external force to lock its position in tissues. Different microstructures of suture anchors are systematically designed using orthogonal arrays, and selected based on shape factors associated with mechanical strength...
November 16, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29142998/covalent-post-assembly-modification-in-metallosupramolecular-chemistry
#18
REVIEW
Derrick A Roberts, Ben S Pilgrim, Jonathan R Nitschke
A growing variety of covalent reactions have been employed to achieve the post-assembly modification (PAM) of self-assembled metallosupramolecular complexes. Covalent PAM enables the late-stage derivatisation of pre-assembled parent complexes in a modular fashion, thus expanding the chemical space available for supramolecular synthesis. The oldest and most widespread implementation of covalent PAM is in metal-preorganised covalent synthesis. Recent work, however, has broadened the scope of covalent PAM to include: protocols for efficiently grafting new functionalities onto supramolecular architectures, reactions that permanently 'lock-down' metastable complexes, and covalent bond-forming stimuli that trigger controlled structural transformations between distinct supramolecular species...
November 16, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29142019/molecular-imaging-of-glut1-and-glut5-in-breast-cancer-a-multitracer-pet-imaging-study-in-mice
#19
Melinda Wuest, Ingrit Hamann, Vincent Bouvet, Darryl Glubrecht, Alison Marshall, Brendan Trayner, Olivier Soueidan, Daniel Krys, Michael Wagner, Chris Cheeseman, Frederick West, Frank Wuest
Use of [18F]FDG-PET in clinical breast cancer (BC) imaging is limited mainly due to insufficient expression levels of GLUT1 in up to 50% of all patients. Fructose-specific facilitative hexose transporter GLUT5 represents an alternative biomarker for PET imaging of hexose metabolism in BC. The goal of the present study was to compare uptake characteristics of selected hexose-based PET radiotracers in murine BC model EMT6. Uptake of 1-deoxy-1-[18F]fluoro-D-fructose (1-[18F]FDF), 6-deoxy-6-[18F]fluoro-D-fructose (6-[18F]FDF), 1-deoxy-1-[18F]fluoro-2,5-anhydro-mannitol (1-[18F]FDAM), 2-deoxy-2-[18F]fluoro-D-glucose (2-[18F]FDG) and 6-deoxy-6-[18F]fluoro-D-glucose (6-[18F]FDG) was studied in EMT6 cells, tumors and muscle and correlated to GLUT1 and GLUT5 expression levels...
November 15, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/29140981/wavelet-brain-angiography-suggests-arteriovenous-pulse-wave-phase-locking
#20
William E Butler
When a stroke volume of arterial blood arrives to the brain, the total blood volume in the bony cranium must remain constant as the proportions of arterial and venous blood vary, and by the end of the cardiac cycle an equivalent volume of venous blood must have been ejected. I hypothesize the brain to support this process by an extraluminally mediated exchange of information between its arterial and venous circulations. To test this I introduce wavelet angiography methods to resolve single moving vascular pulse waves (PWs) in the brain while simultaneously measuring brain pulse motion...
2017: PloS One
keyword
keyword
84759
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"