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https://www.readbyqxmd.com/read/28647722/developing-implementation-strategies-for-firearm-safety-promotion-in-paediatric-primary-care-for-suicide-prevention-in-two-large-us-health-systems-a-study-protocol-for-a-mixed-methods-implementation-study
#1
Courtney Benjamin Wolk, Shari Jager-Hyman, Steven C Marcus, Brian K Ahmedani, John E Zeber, Joel A Fein, Gregory K Brown, Adina Lieberman, Rinad S Beidas
INTRODUCTION: The promotion of safe firearm practices, or firearms means restriction, is a promising but infrequently used suicide prevention strategy in the USA. Safety Check is an evidence-based practice for improving parental firearm safety behaviour in paediatric primary care. However, providers rarely discuss firearm safety during visits, suggesting the need to better understand barriers and facilitators to promoting this approach. This study, Adolescent Suicide Prevention In Routine clinical Encounters, aims to engender a better understanding of how to implement the three firearm components of Safety Check as a suicide prevention strategy in paediatric primary care...
June 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28647193/cryopreserved-venous-allograft-is-an-acceptable-conduit-in-patients-with-current-or-prior-angioaccess-graft-infection
#2
Michael P Harlander-Locke, Peter F Lawrence, Aamna Ali, Esther Bae, James Kohn, Christopher Abularrage, Michael Ricci, Gary W Lemmon, Sotero Peralta, Jeffrey Hsu
OBJECTIVE: The durability of cryopreserved allograft has been previously demonstrated in the setting of infection. The objective of this study was to examine the safety, efficacy, patency, and cost per day of graft patency associated with using cryopreserved allograft (vein and artery) for hemodialysis access in patients with no autogenous tissue for native fistula creation and with arteriovenous graft infection or in patients at high risk for infection. METHODS: Patients implanted with cryopreserved allograft for hemodialysis access between January 2004 and January 2014 were reviewed using a standardized, multi-institutional database that evaluated demographic, comorbidity, procedural, and outcomes data...
June 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28643788/terahertz-saturable-absorbers-from-liquid-phase-exfoliation-of-graphite
#3
Vezio Bianchi, Tian Carey, Leonardo Viti, Lianhe Li, Edmund H Linfield, A Giles Davies, Alessandro Tredicucci, Duhee Yoon, Panagiotis G Karagiannidis, Lucia Lombardi, Flavia Tomarchio, Andrea C Ferrari, Felice Torrisi, Miriam S Vitiello
Saturable absorbers (SA) operating at terahertz (THz) frequencies can open new frontiers in the development of passively mode-locked THz micro-sources. Here we report the fabrication of THz SAs by transfer coating and inkjet printing single and few-layer graphene films prepared by liquid phase exfoliation of graphite. Open-aperture z-scan measurements with a 3.5 THz quantum cascade laser show a transparency modulation ∼80%, almost one order of magnitude larger than that reported to date at THz frequencies...
June 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28642671/subchondral-raft-construction-with-locking-plates-for-the-treatment-of-schatzker-type-ii-fractures
#4
Cemil Kayali, Caner Citak, Taskin Altay, Zafer Kement
OBJECTIVES: To evaluate the functional and radiological results of Schatzker type II fractures treated via subchondral raft screws combined with locking plates. METHODS: Twenty-four individuals were enrolled in this study between 2010 and 2014. The depressed joint line was elevated and the defect was filled with allograft. Next, two or three subchondral screws were placed in combination with a locking plate. At the last follow-up, clinical and radiological data were recorded...
May 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28642257/interaction-between-the-fto-gene-body-mass-index-and-depression-meta-analysis-of-13701-individuals
#5
REVIEW
Margarita Rivera, Adam E Locke, Tanguy Corre, Darina Czamara, Christiane Wolf, Ana Ching-Lopez, Yuri Milaneschi, Stefan Kloiber, Sara Cohen-Woods, James Rucker, Katherine J Aitchison, Sven Bergmann, Dorret I Boomsma, Nick Craddock, Michael Gill, Florian Holsboer, Jouke-Jan Hottenga, Ania Korszun, Zoltan Kutalik, Susanne Lucae, Wolfgang Maier, Ole Mors, Bertram Müller-Myhsok, Michael J Owen, Brenda W J H Penninx, Martin Preisig, John Rice, Marcella Rietschel, Federica Tozzi, Rudolf Uher, Peter Vollenweider, Gerard Waeber, Gonneke Willemsen, Ian W Craig, Anne E Farmer, Cathryn M Lewis, Gerome Breen, Peter McGuffin
BackgroundDepression and obesity are highly prevalent, and major impacts on public health frequently co-occur. Recently, we reported that having depression moderates the effect of the FTO gene, suggesting its implication in the association between depression and obesity.AimsTo confirm these findings by investigating the FTO polymorphism rs9939609 in new cohorts, and subsequently in a meta-analysis.MethodThe sample consists of 6902 individuals with depression and 6799 controls from three replication cohorts and two original discovery cohorts...
June 22, 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28642248/evaluation-of-a-community-based-safe-firearm-and-ammunition-storage-intervention
#6
Joseph A Simonetti, Ali Rowhani-Rahbar, Cassie King, Elizabeth Bennett, Frederick P Rivara
BACKGROUND: Safe firearm storage practices are associated with a lower risk of unintentional and self-inflicted firearm injuries among household members, though many firearms remain unlocked and/or loaded. OBJECTIVES: Conduct a preliminary evaluation of a community-based firearm safety intervention and assess participants' preferences for firearm locking devices and their comfort with potential firearm safety counsellors. DESIGN/METHODS: Baseline event and follow-up surveys among adult participants to assess changes in firearm storage practices, including whether all household firearms were stored locked, all were unloaded, all ammunition was locked, and a composite measure assessing whether all firearms were locked and unloaded and all ammunition was stored locked...
June 22, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28641112/molecular-mechanism-of-mdga1-regulation-of-neuroligin-2-neurexin-trans-synaptic-bridges
#7
Shanti Pal Gangwar, Xiaoying Zhong, Suchithra Seshadrinathan, Hui Chen, Mischa Machius, Gabby Rudenko
Neuroligins and neurexins promote synapse development and validation by forming trans-synaptic bridges spanning the synaptic cleft. Select pairs promote excitatory and inhibitory synapses, with neuroligin 2 (NLGN2) limited to inhibitory synapses and neuroligin 1 (NLGN1) dominating at excitatory synapses. The cell-surface molecules, MAM domain-containing glycosylphosphatidylinositol anchor 1 (MDGA1) and 2 (MDGA2), regulate trans-synaptic adhesion between neurexins and neuroligins, impacting NLGN2 and NLGN1, respectively...
June 21, 2017: Neuron
https://www.readbyqxmd.com/read/28640993/locking-in-optimal-nanoscale-structure-induced-by-naphthalenediimide-based-polymeric-additive-enables-efficient-and-stable-inverted-polymer-solar-cells
#8
Kwang Hyun Park, Yujin An, Seungon Jung, Hyesung Park, Changduk Yang
Operational stability and high performance are the most critical issues that must be addressed in order to propel and advance the current polymer solar cell (PSC) technology to the next level such as manufacturing and mass production. Herein, we report a high power conversion efficiency (PCE) of 11.2% together with an excellent device stability in PTB7-Th:PC71BM-based PSCs in the inverted structure by introducing the n-type P(NDI2OD-T2) macromolecular additive (>75% PCE retention at high temperature up to 120 °C, >97% PCE retention after 6 months in inert conditions, >93% PCE retention after 2 months in air with encapsulation, and >80% PCE retention after 140 h in air without encapsulation)...
June 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28640396/an-anatomical-study-of-plate-rod-fixation-in-feline-tibiae
#9
Andreas Gutbrod, Simona Vincenti, Karolin Kühn, Sebastian Christoph Knell, Philipp Alexander Schmierer, Antonio Pozzi
OBJECTIVE: To investigate the feasibility of placing bi-cortical cortex (B-cort) or mono-cortical locking screws (M-lock) in a plate-rod construct applied to the feline tibia in combination with different intramedullary (IM) pins. METHODS: Twenty-four feline tibiae of cats were divided into 4 groups, corresponding to IM pin sizes filling approximately 30% (1.0 mm), 40% (1.4 mm), 45% (1.6 mm), and 50% (1.8 mm) of the medullary canal. Computed tomography (CT) was performed to trace potential screw trajectories in each group...
June 22, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28640188/novel-concrete-temperature-monitoring-method-based-on-an-embedded-passive-rfid-sensor-tag
#10
Yongsheng Liu, Fangming Deng, Yigang He, Bing Li, Zhen Liang, Shuangxi Zhou
This paper firstly introduces the importance of temperature control in concrete measurement, then a passive radio frequency identification (RFID) sensor tag embedded for concrete temperature monitoring is presented. In order to reduce the influences of concrete electromagnetic parameters during the drying process, a T-type antenna is proposed to measure the concrete temperature at the required depth. The proposed RFID sensor tag is based on the EPC generation-2 ultra-high frequency (UHF) communication protocol and operates in passive mode...
June 22, 2017: Sensors
https://www.readbyqxmd.com/read/28639486/estimated-prevalence-of-the-target-population-for-brain-computer-interface-neurotechnology-in-the-netherlands
#11
Elmar G M Pels, Erik J Aarnoutse, Nick F Ramsey, Mariska J Vansteensel
BACKGROUND: People who suffer from paralysis have difficulties participating in society. Particularly burdensome is the locked-in syndrome (LIS). LIS patients are not able to move and speak but are cognitively healthy. They rely on assistive technology to interact with the world and may benefit from neurotechnological advances. Optimal research and design of such aids requires a well-defined target population. However, the LIS population is poorly characterized and the number of patients in this condition is unknown...
June 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28639239/significant-improvement-in-detecting-braf-kras-and-egfr-mutations-using-next-generation-sequencing-as-compared-with-fda-cleared-kits
#12
Wanlong Ma, Steven Brodie, Sally Agersborg, Vincent A Funari, Maher Albitar
INTRODUCTION: We compared mutations detected in EGFR, KRAS, and BRAF genes using next-generation sequencing (NGS) and confirmed by Sanger sequencing with mutations that could be detected by FDA-cleared testing kits. METHODS: Paraffin-embedded tissue from 822 patients was tested for mutations in EGFR, KRAS, and BRAF by NGS. Sanger sequencing of hot spots was used with locked nucleic acid to increase sensitivity for specific hot-spot mutations. This included 442 (54%) lung cancers, 168 (20%) colorectal cancers, 29 (4%) brain tumors, 33 (4%) melanomas, 14 (2%) thyroid cancers, and 16% others (pancreas, head and neck, and cancer of unknown origin)...
June 21, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28638700/vowel-decoding-from-single-trial-speech-evoked-electrophysiological-responses-a-feature-based-machine-learning-approach
#13
Han G Yi, Zilong Xie, Rachel Reetzke, Alexandros G Dimakis, Bharath Chandrasekaran
INTRODUCTION: Scalp-recorded electrophysiological responses to complex, periodic auditory signals reflect phase-locked activity from neural ensembles within the auditory system. These responses, referred to as frequency-following responses (FFRs), have been widely utilized to index typical and atypical representation of speech signals in the auditory system. One of the major limitations in FFR is the low signal-to-noise ratio at the level of single trials. For this reason, the analysis relies on averaging across thousands of trials...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28638693/management-of-the-temporomandibular-joint-in-inflammatory-arthritis-involvement-of-surgical-procedures
#14
REVIEW
Rory C O'Connor, Fiona Fawthrop, Rami Salha, Andrew J Sidebottom
Many conditions may affect the temporomandibular joint (TMJ), but its incidence in individual joint diseases is low. However, inflammatory arthropathies, particularly rheumatoid and psoriatic arthritis and ankylosing spondylitis, appear to have a propensity for affecting the joint. Symptoms include pain, restriction in mouth opening, locking, and noises, which together can lead to significant impairment. Jaw rest, a soft diet, a bite splint, and medical therapy, including disease-modifying antirheumatic drugs (DMARDs) and simple analgesia, are the bedrock of initial treatment and will improve most symptoms in most patients...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28638402/dna-methylation-nuclear-organization-and-cancer
#15
REVIEW
Bhavani P Madakashira, Kirsten C Sadler
The dramatic re-organization of the cancer cell nucleus creates telltale morphological features critical for pathological staging of tumors. In addition, the changes to the mutational and epigenetic landscape in cancer cells alter the structure and stability of the genome and directly contribute to malignancy. DNA methylation is one of the best studied epigenetic changes in cancer, as nearly every type of cancer studied shows a loss of DNA methylation spread across most of the genome. This global hypomethylation is accompanied by hypermethylation at distinct loci, and much of the work on DNA methylation in cancer has focused on how local changes contribute to gene expression...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28638384/induced-regulatory-t-cells-superimpose-their-suppressive-capacity-with-effector-t-cells-in-lymph-nodes-via-antigen-specific-s1p1-dependent-egress-blockage
#16
Shuang Geng, Yiwei Zhong, Xiaoyu Zhou, Gan Zhao, Xiaoping Xie, Yechun Pei, Hu Liu, Huiyuan Zhang, Yan Shi, Bin Wang
Regulatory T cells (Tregs) restrict overexuberant lymphocyte activation. While close proximity between Tregs and their suppression targets is important for optimal inhibition, and literature indicates that draining lymph nodes (LNs) may serve as a prime location for the suppression, signaling details orchestrating this event are not fully characterized. Using a protocol to enable peripheral generation of inducible antigen-specific Tregs (asTregs) to control allergen-induced asthma, we have identified an antigen-specific mechanism that locks asTregs within hilar LNs which in turn suppresses airway inflammation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28637185/a-novel-method-of-open-reduction-and-internal-fixation-of-a-displaced-manubrial-fracture-using-distal-clavicle-locking-plates
#17
Daniel Miller, M Adeel Akhtar, Jonathan Fergusson, James L McVie
A 52-year-old man sustained a sternal fracture after a blunt traumatic chest injury. He was in severe pain in the intensive care unit, which resulted in difficulty breathing and increased analgesic requirement, and a decision was made to stabilize his manubrial fracture. Orthopaedic and thoracic surgeons jointly performed open reduction and internal fixation of the displaced manubrial fracture using 2 distal clavicle locking plates. This resulted in improvement in patient's pain and helped with his subsequent recovery and discharge from the hospital...
June 20, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28636055/effect-of-headless-compression-screw-on-construct-stability-for-centre-of-rotation-and-angulation-based-levelling-osteotomy-biomechanical-testing-in-flexion-and-torsion
#18
Michelle R Meyer, Mireya A Perez, Mohammad S Hossain, Edward B Silverman, Randall B Fitch, Ryan B Wicker
OBJECTIVE: To compare the biomechanical properties of bone and implant constructs when used for the centre of rotation and angulation (CORA) based levelling osteotomy, with and without implantation of a trans-osteotomy headless compression screw tested under three-point flexural and torsional forces; thereby determining the contribution of a trans-osteotomy headless compression screw with regards to stability of the construct. METHODS: Experimental biomechanical study utilizing 12 pairs of cadaveric canine tibias...
June 21, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28635497/desynchronisation-of-auditory-steady-state-responses-related-to-changes-in-interaural-phase-differences-an-objective-measure-of-binaural-hearing
#19
Charlotte Vercammen, Astrid van Wieringen, Jan Wouters, Tom Francart
OBJECTIVE: Binaural processing can be measured objectively as a desynchronisation of phase-locked neural activity to changes in interaural phase differences (IPDs). This was reported in a magnetoencephalography study for 40 Hz amplitude modulated tones. The goal of this study was to measure this desynchronisation using electroencephalography and explore the outcomes for different modulation frequencies. DESIGN: Auditory steady-state responses (ASSRs) were recorded to pure tones, amplitude modulated at 20, 40 or 80 Hz...
February 14, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28634743/comminuted-olecranon-fractures-biomechanical-testing-of-locked-versus-minifragment-non-locked-plate-fixation
#20
David S Wellman, Scott M Tucker, Josh R Baxter, Nadine C Pardee, Lionel E Lazaro, Christopher S Smith, Dean G Lorich, David L Helfet
INTRODUCTION: Open reduction and internal fixation has long been accepted as optimal treatment for displaced olecranon fractures based on poor results seen with conservative management. With the presence of comminution, tension-band wiring constructs are contraindicated due to tendency to compress through fragments, thereby shortening the articular segment. Therefore, plate fixation is typically employed. Our hypothesis was that in a comminuted fracture model, 2.7 mm reconstruction plating without locking screws will perform equally to 3...
June 20, 2017: Archives of Orthopaedic and Trauma Surgery
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