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https://www.readbyqxmd.com/read/27913364/an-intelligible-risk-stratification-model-based-on-pairwise-and-size-constrained-kmeans
#1
Longfei Han, Senlin Luo, Huaiqing Wang, Limin Pan, Xincheng Ma, Tiemei Zhang
Having a system to stratify individuals according to risk is key to clinical disease prevention, this allows individuals identified at different risk tiers benefit from further investigation and intervention. But the same risk score estimated for two different persons doesn't mean they need the same further investigation or represent the similarity health condition between two persons. Meanwhile, users still does not know a prior what most of the risk tiers are, and how many tiers should be found in risk stratification...
November 29, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/27903156/american-society-of-clinical-oncology-obesity-initiative-rationale-progress-and-future-directions
#2
Jennifer A Ligibel, Dana Wollins
Obesity is increasingly being linked to the risk of developing and dying from cancer. In recognition of the growing contribution of obesity to cancer risk and outcomes, ASCO made obesity and cancer one of its core initiatives in 2014. The goals of this initiative included raising awareness of the relationship between obesity and cancer, providing tools and resources to oncology providers and patients to help encourage conversations regarding weight management in cancer survivors, fostering a robust research agenda, and advocating for access to evidence-based weight management programs for cancer survivors...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27896445/serum-1-5-anhydroglucitol-level-as-a-screening-tool-for-diabetes-mellitus-in-a-community-based-population-at-high-risk-of-diabetes
#3
Yao Wang, Yuexing Yuan, Yanli Zhang, Chenghao Lei, Yi Zhou, Jiajia He, Zilin Sun
AIMS: Early diagnosis of diabetes yields significant clinical benefits; however, currently available diagnostic tools for community-based population are limited. This study aimed to assess the value of serum 1,5-anhydroglucitol (1,5-AG) for the diagnosis and screening of diabetes mellitus in a community-based population at high risk of diabetes. METHODS: In this diagnostic test, 1170 participants underwent a 75-g oral glucose tolerance test. Venous blood samples were collected for fasting blood glucose (FBG), 2-h postprandial blood glucose (PBG), and glycosylated hemoglobin A1c (HbA1c) measurements...
November 28, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27891527/the-multimorbidity-index-a-tool-for-assessing-the-prognosis-of-patients-from-their-history-of-illness
#4
Farrokh Alemi, Cari R Levy, Raya E Kheirbek
BACKGROUND: The Multimorbidity (MM) Index predicts the prognosis of patients from their diagnostic history. In contrast to existing approaches with broad diagnostic categories, it treats each diagnosis as a separate independent variable using individual International Classification of Disease, Revision 9 (ICD-9) codes. OBJECTIVE: This paper describes the MM Index, reviews the published data on its accuracy, and provides procedures for implementing the Index within electronic health record (EHR) systems...
2016: EGEMS
https://www.readbyqxmd.com/read/27891331/association-of-diabetic-nephropathy-and-liver-disorders
#5
Usha Sachidananda Adiga, B N Malawadi
INTRODUCTION: Liver disorder is known to be a risk factor for Diabetes Mellitus (DM) and diabetic patients are at risk of developing liver disorders. Association of liver and renal disease is less explored in the field of research; hence, we conducted a retrospective study on this. AIM: To compare the renal and liver profiles of type II DM patients compared to healthy controls and find the association between the two profiles in diabetics. MATERIALS AND METHODS: The renal and liver profiles of 68 type II DM patients and 58 controls were compared...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889823/goshajinkigan-for-reducing-chemotherapy-induced-peripheral-neuropathy-protocol-for-a-systematic-review-and-meta-analysis
#6
Nobuaki Hoshino, Koya Hida, Riki Ganeko, Yoshiharu Sakai
PURPOSE: Chemotherapy-induced peripheral neuropathy (CIPN) is an issue for both cancer patients and specialists, and the number of cases of CIPN is growing with the increasing number of cancer patients worldwide. CIPN is often caused by common anticancer drugs such as taxanes and platinum analogs. These are key drugs for various cancers including colorectal and gastric cancers. However, there are currently no effective drugs to prevent CIPN. Goshajinkigan, a Japanese traditional herbal medicine (Kampo), is a promising drug which is used to treat diabetic neuropathy in Japan...
November 26, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27888412/diabetes-screening-in-overweight-and-obese-children-and-adolescents-choosing-the-right-test
#7
Stefan Ehehalt, Susanna Wiegand, Antje Körner, Roland Schweizer, Klaus-Peter Liesenkötter, Carl-Joachim Partsch, Gunnar Blumenstock, Ulrike Spielau, Christian Denzer, Michael B Ranke, Andreas Neu, Gerhard Binder, Martin Wabitsch, Wieland Kiess, Thomas Reinehr
: Type 2 diabetes can occur without any symptoms, and health problems associated with the disease are serious. Screening tests allowing an early diagnosis are desirable. However, optimal screening tests for diabetes in obese youth are discussed controversially. We performed an observational multicenter analysis including 4848 (2668 female) overweight and obese children aged 7 to 17 years without previously known diabetes. Using HbA1c and OGTT as diagnostic criteria, 2.4% (n = 115, 55 female) could be classified as having diabetes...
November 25, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27879226/speech-evoked-auditory-brainstem-response-in-individuals-with-diabetes-mellitus-type-2
#8
Himanshu Kumar Sanju, Akhil Mohanan, Prawin Kumar
OBJECTIVE: Diabetes is the most common glucose level dependent metabolic disorder and studies have shown that hearing impairment can be a long-term subclinical complication. Studies to investigate auditory system involvement in diabetes has focused majorly on the auditory brainstem response (ABR), otoacoustic emission, and basic audiological measures. Hence in the current study, we used speech-evoked ABR (S-ABR) as a tool to see the effect of diabetes on both a transient and sustained response of the auditory brainstem to a conventionally used consonant-vowel (CV) stimuli /da/...
November 23, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27874948/epicardial-fat-thickness-is-associated-with-severity-of-disease-in-patients-with-chronic-obstructive-pulmonary-disease
#9
K Kiraz, T Gökdeniz, E Kalaycıoglu, A Börekçi, S Akyol, A O Baykan, A Acele, S Karakoyun, T Seker, M Gür
OBJECTIVE: Cardiovascular diseases (CVD) are common in patients with chronic obstructive pulmonary disease (COPD) and the BODE index is an important tool for the prognostic assessment of COPD patients. It is well known that epicardial fat thickness (EFT) is related to CVD. However, there are very few data about the relationship between EFT and BODE index. The aim of this study is to investigate the relationship between EFT and BODE index in patients with COPD. PATIENTS AND METHODS: We prospectively included 157 patients with COPD and 45 controls in the present study...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27873225/how-consistent-is-the-relationship-between-improved-glucose-control-and-modelled-health-outcomes-for-people-with-type-2-diabetes-mellitus-%C3%A2-a-systematic-review
#10
REVIEW
Xinyang Hua, Thomas Wai-Chun Lung, Andrew Palmer, Lei Si, William H Herman, Philip Clarke
BACKGROUND: There are an increasing number of studies using simulation models to conduct cost-effectiveness analyses for type 2 diabetes mellitus. OBJECTIVE: To evaluate the relationship between improvements in glycosylated haemoglobin (HbA1c) and simulated health outcomes in type 2 diabetes cost-effectiveness studies. METHODS: A systematic review was conducted on MEDLINE and EMBASE to collect cost-effectiveness studies using type 2 diabetes simulation models that reported modelled health outcomes of blood glucose-related interventions in terms of quality-adjusted life-years (QALYs) or life expectancy (LE)...
November 21, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27871509/a-cross-sectional-study-of-preoperative-medication-adherence-and-early-postoperative-recovery
#11
Anthony P Notaras, Elisabeth Demetriou, Jessica Galvin, Erez Ben-Menachem
STUDY OBJECTIVE: To quantify the impact of preoperative medication adherence on recovery length of stays and complication rates. DESIGN: Cross-sectional analytical study. SETTING: Postanesthetic care unit (PACU) of a single-center tertiary hospital. PATIENTS: Surgical patients admitted for surgery at our institution over a 4-month period. INTERVENTION: A data collection tool was used to collect demographic data, length of stay in recovery, prespecified conditions likely to impact on PACU recovery (chronic pain, insulin-dependent diabetes, epilepsy, hypertension, on a methadone program, and Parkinson disease), medication compliance, and complications in PACU...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27870552/glycemic-predictors-of-insulin-independence-after-total-pancreatectomy-with-islet-auto-transplantation
#12
Michael Quartuccio, Erica Hall, Vikesh Singh, Martin A Makary, Kenzo Hirose, Niraj Desai, Christi Walsh, Daniel Warren, Zhaoli Sun, Ellen Stein, Rita R Kalyani
CONTEXT: Total pancreatectomy with islet auto transplantation (TPIAT) is a treatment for medically refractory chronic pancreatitis that can prevent postsurgical diabetes in a subset of patients. Predictors of insulin independence are needed for appropriate patient selection and counseling. OBJECTIVE: To explore glycemic predictors of insulin independence after TPIAT. DESIGN: A prospective cohort of patients undergoing TPIAT from 2011-2016...
November 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27865808/postprandial-hyperinsulinemic-hypoglycemia-after-roux-en-y-gastric-bypass-an-update
#13
Caroline Christfort Øhrstrøm, Dorte Worm, Dorte Lindqvist Hansen
Roux-en-Y gastric bypass (RYGB) is an efficient treatment for morbid obesity and reduces obesity-related co-morbidities. With the growing number of patients undergoing gastric bypass, complications now demand further attention. Postprandial hyperinsulinemic hypoglycemia (PHH) after Roux-en-Y gastric bypass is a complex condition, characterized by increased glucose variability including both hyperglycemic and hypoglycemic values. PHH seems to be more prevalent than previously suggested and is highly dependent on the choice of diagnostic tool, which has not yet been standardized...
September 28, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27825607/linguistic-and-psychometric-validation-of-the-malaysian-version-of-diabetes-quality-of-life-brief-clinical-inventory-dqol-bci
#14
Syamimi Samah, Chin Fen Neoh, Yuet Yen Wong, Mohamed Azmi Hassali, Asrul Akmal Shafie, Siong Meng Lim, Kalavathy Ramasamy, Nafiza Mat Nasir, Yung Wen Han, Thomas Burroughs
BACKGROUND: Quality of life (QoL) assessment provides valuable outcome to support clinical decision-making, particularly for patients with chronic diseases that are incurable. A brief, 15-item diabetes-specific tool [i.e. Diabetes Quality of Life-Brief Clinical Inventory (DQoL-BCI)] is known to be developed in English and validated for use in clinical practice. This simplified tool, however, is not readily available for use in the Malaysian setting. OBJECTIVE: To translate the DQoL-BCI into a Malaysian version and to assess its construct validity (factorial validity, convergent validity and discriminant validity), reliability (internal consistency) and floor and ceiling effects among the Malaysian diabetic population...
October 24, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/27812606/association-of-the-conicity-index-with-diabetes-and-hypertension-in-brazilian-women
#15
Mirelli Dantas Andrade, Maria Camila Pruper de Freitas, Alyne Mayumi Sakumoto, Caroline Pappiani, Samantha Caesar de Andrade, Viviane Laudelino Vieira, Nágila Raquel Teixeira Damasceno
Objective: The goal of this study was evaluate the conicity index (C index) in women and its association with hypertension (SAH) and diabetes mellitus (DM). Subjects and methods: This was a cross-sectional study, with 573 women between 20 and 59 years of age. After analysis of clinical and demographic characteristics, anthropometric variables were measured and used to calculate the C index. Plasma glucose and lipid profile were evaluated by standard methods. The analysis of the results was based on logistic regression and the odds ratio (OR) was calculated, which was used to assess the association of the variable outcome with the variable exposure using two logistic regression models that tested the possible influence of the C index in the chance of developing SAH or DM...
October 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27805331/a-prospective-study-on-utility-of-exercise-treadmill-test-in-type-2-diabetes-mellitus-patients
#16
Meenaxi Sharda, Anil Kumar Soni, Shivraj Meena, Harish Nigam, Anuraj Singh
OBJECTIVE: Primary objective of this study was to access utility of exercise treadmill test in type-2 diabetes mellitus patients for detecting silent myocardial ischaemia and associated risk factors. METHODS: 75 DM-2 cases were enrolled in study of any age attending medical OPD. All cases were gone through detailed history and TMT procedure. RESULTS: There is higher prevalence of SMI in DM-2 patients. TMT positivity for inducible ischaemia in DM-2 patients were associated with increasing age, male sex, higher BMI, hypertension, smoking, alcoholism, microalbuminuria, macroalbuminuria and dyslipidemia...
November 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27799136/the-use-of-ehealth-and-provider-based-health-services-by-patients-with-diabetes-mellitus-protocol-for-a-cross-sectional-study
#17
Anne Helen Hansen, Meghan Bradway, Jan Broz, Tor Claudi, Øystein Henriksen, Silje C Wangberg, Eirik Årsand
BACKGROUND: The prevalence of diabetes and the use of electronic health (eHealth) resources are increasing. People with diabetes need frequent monitoring and follow-up of health parameters, and eHealth services can be of great significance in this regard. However, little is known about the extent to which different kinds of eHealth tools are used, and how the use of eHealth is associated with the use of provider-based health care services among people with diabetes. OBJECTIVE: The primary objective of this study is to investigate the use of eHealth and its association with the use of provider-based health care services...
October 31, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27794624/modelling-the-oral-glucose-tolerance-test-in-normal-and-impaired-glucose-tolerant-states-a-population-approach
#18
Michael J Theodorakis, Niki Katsiki, Kalliopi Arampatzi, George P Chrousos
Objective The conventional approach to analyzing data from oral glucose tolerance testing (OGTT) requires model identification in each individual separately (standard two stage, STS), ignoring knowledge about the population as a whole. In practice, however, the OGTT is sparsely sampled and individual estimates are often not resolvable from available data. This weakness is often encountered in large scale trials or epidemiological studies, leading to either multiple imputations or simply much less data available for analysis...
October 31, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27783805/effects-of-endurance-training-on-reduction-of-plasma-glucose-during-high-intensity-constant-and-incremental-speed-tests-in-wistar-rats
#19
P Abreu, K F Vitzel, I C C R Monteiro, T I Lima, A N Queiroz, J H Leal-Cardoso, S M Hirabara, V M Ceccatto
The aim of this research was to investigate the effects of endurance training on reduction of plasma glucose during high intensity constant and incremental speed tests in Wistar rats. We hypothesized that plasma glucose might be decreased in the exercised group during heavy (more intense) exercise. Twenty-four 10-week-old male Wistar rats were randomly assigned to sedentary and exercised groups. The prescription of endurance exercise training intensity was determined as 60% of the maximum intensity reached at the incremental speed test...
October 24, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/27783546/risk-of-nondherence-to-diabetes-medications-among-medicare-advantage-enrollees-development-of-a-validated-risk-prediction-tool
#20
Shivani K Mhatre, Omar Serna, Shubhada Sansgiry, Marc L Fleming, E James Essien, Sujit S Sansgiry
BACKGROUND: Low adherence to oral antidiabetic drugs (OADs) in the Medicare population can greatly reduce Centers for Medicare & Medicaid Services (CMS) star ratings for managed care organizations (MCOs). OBJECTIVE: To develop and validate a risk assessment tool (Prescription Medication Adherence Prediction Tool for Diabetes Medications [RxAPT-D]) to predict nonadherence to OADs using Medicare claims data. METHODS: In this retrospective observational study, claims data for members enrolled in a Medicare Advantage Prescription Drug (MA-PD) program in Houston, Texas, were used...
November 2016: Journal of Managed Care & Specialty Pharmacy
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