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https://www.readbyqxmd.com/read/29456428/strategies-to-improve-prevention-and-management-in-diabetic-retinopathy-qualitative-insights-from-a-mixed-methods-study
#1
Richard S Beaser, Wendy A Turell, Alexandra Howson
Nonproliferative and proliferative diabetic retinopathy (DR) are common, progressive complications of diabetes with a rising incidence. Over time, patients with nonproliferative DR may progress to more advanced stages of DR, with an increased risk of vision-threatening conditions such as diabetic macular edema (DME). DME is the most frequent cause of vision loss in patients with diabetes and eventually can lead to blindness. Early-stage DR is asymptomatic; therefore, a coordinated management strategy is crucial to prevent or limit the progression of DR...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29456424/diabetes-risk-assessment-in-latinas-effectiveness-of-a-brief-diabetes-risk-questionnaire-for-detecting-prediabetes-in-a-community-based-sample
#2
Adam B Scanlan, Catarina M Maia, Alberly Perez, Carol J Homko, Matthew J O'Brien
Objective: Numerous validated questionnaires use self-reported data to quantify individuals' risk of having diabetes or developing it in the future. Evaluations of these tools have primarily used nationally representative data, limiting their application in clinical and community settings. This analysis tested the effectiveness of the American Diabetes Association (ADA) risk questionnaire for identifying prediabetes in a community-based sample of Latinas. Methods: Data were collected using the ADA risk questionnaire and assessing A1C...
February 2018: Diabetes Spectrum: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/29453154/unique-pharmacology-of-a-novel-allosteric-agonist-sensitizer-insulin-receptor-monoclonal-antibody
#3
Simon A Hinke, Anne M Cieniewicz, Thomas Kirchner, Katharine D'Aquino, Rupesh Nanjunda, Jason Aligo, Robert Perkinson, Philip Cooper, Ken Boayke, Mark L Chiu, Steve Jarantow, Eilyn R Lacy, Yin Liang, Dana L Johnson, Jean M Whaley, Russell B Lingham, Anthony J Kihm
OBJECTIVE: Insulin resistance is a key feature of Type 2 Diabetes (T2D), and improving insulin sensitivity is important for disease management. Allosteric modulation of the insulin receptor (IR) with monoclonal antibodies (mAbs) can enhance insulin sensitivity and restore glycemic control in animal models of T2D. METHODS: A novel human mAb, IRAB-A, was identified by phage screening using competition binding and surface plasmon resonance assays with the IR extracellular domain...
February 3, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29449958/a-mobile-phone-based-program-to-promote-healthy-behaviors-among-adults-with-prediabetes-study-protocol-for-a-pilot-randomized-controlled-trial
#4
Dina H Griauzde, Jeffrey T Kullgren, Brad Liestenfeltz, Caroline Richardson, Michele Heisler
Background: Rates of participation in Diabetes Prevention Programs (DPPs) are low. This may be due, in part, to low levels of autonomous motivation (i.e., motivation that arises from internal sources and sustains healthy behaviors over time) to prevent type 2 diabetes (T2DM) among many individuals with prediabetes. Mobile health (mHealth) technologies that incorporate principles from the Self-Determination Theory offer an effective and scalable approach to increase autonomous motivation levels...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29443485/effectiveness-of-the-canrisk-tool-in-the-identification-of-dysglycemia-in-first-nations-and-m%C3%A3-tis-in-canada
#5
Gina Agarwal, Ying Jiang, Susan Rogers Van Katwyk, Chantal Lemieux, Heather Orpana, Yang Mao, Brandan Hanley, Karen Davis, Laurel Leuschen, Howard Morrison
INTRODUCTION: First Nations/Métis populations develop diabetes earlier and at higher rates than other Canadians. The Canadian diabetes risk questionnaire (CANRISK) was developed as a diabetes screening tool for Canadians aged 40 years or over. The primary aim of this paper is to assess the effectiveness of the existing CANRISK tool and risk scores in detecting dysglycemia in First Nations/Métis participants, including among those under the age of 40. A secondary aim was to determine whether alternative waist circumference (WC) and body mass index (BMI) cut-off points improved the predictive ability of logistic regression models using CANRISK variables to predict dysglycemia...
February 2018: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29441963/do-patients-with-diabetes-type-2-or-chronic-heart-failure-understand-a-medication-plan
#6
L Botermann, A Wachter, K Monzel, K Krueger, S Ewen, F Mahfoud, N Griese-Mammen, M Schulz, U Laufs
A standardized medication plan (MP) was recently enacted into German law (§ 31a SGB V). The purpose of our study was to assess if patients with chronic diseases requiring polymedication understand the standardized MP and can transfer the given information into practice. 100 patients who took at least five medicines regularly were prospectively included in a cross-sectional study: 50 patients with the primary diagnosis chronic heart failure (CHF), and 50 with diabetes mellitus type 2 (DMT2). We performed a structured test-scenario studying the handling of a provided MP then evaluated the execution of the information on the MP by filling pill boxes and requested patients' opinion...
December 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441814/analysis-of-gastric-myoelectrical-activity-from-the-electrogastrogram-signals-based-on-wavelet-transform-and-line-length-feature
#7
Abdullah Al Kafee, Aydin Akan
Electrogastrogram is used for the abdominal surface measurement of the gastric electrical activity of the human stomach. The electrogastrogram technique has significant value as a clinical tool because careful electrogastrogram signal recordings and analyses play a major role in determining the propagation and coordination of gastric myoelectric abnormalities. The aim of this article is to evaluate electrogastrogram features calculated by line length features based on the discrete wavelet transform method to differentiate healthy control subjects from patients with functional dyspepsia and diabetic gastroparesis...
February 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29440241/-if-there-were-water-we-should-stop-and-drink-neurofibromatosis-presenting-with-diabetes-insipidus
#8
Rachel Barry, Antoinette O' Connor, Mohn Hazriq Awang, Orna O' Toole
A 58-year-old right-handed woman presented to our institution with a 1-month history of polydipsia and polyuria. She had a remote history of neurofibroma excision by dermatology and, on examination, was noted to meet the clinical diagnostic criteria for neurofibromatosis type 1. Laboratory investigations revealed hypernatraemia and elevated serum osmolality, accompanied by reduced urinary osmolality. A subsequent water deprivation test confirmed central diabetes insipidus, which responded to treatment with desmopressin...
February 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29425836/the-impact-of-a-daily-smartphone-based-feedback-system-among-women-with-gestational-diabetes-on-compliance-glycemic-control-satisfaction-and-pregnancy-outcome-a-randomized-controlled-trial
#9
Hadas Miremberg, Tal Ben-Ari, Tal Betzer, Hagit Raphaeli, Rose Gasnier, Giulia Barda, Jacob Bar, Eran Weiner
BACKGROUND: Patient compliance and tight glycemic control have been demonstrated to improve pregnancy outcome in pregnancies complicated by gestational diabetes mellitus (GDM). The use of advanced technological tools, including smartphone-based platforms, to improve medical care and outcomes has been demonstrated in various fields of medicine, but only few small studies were performed with GDM patients. OBJECTIVE: We aimed to study the impact of introducing a smartphone-based daily feedback and communication platform between GDM patients and their physicians, on patient compliance, glycemic control, pregnancy outcome, and patient satisfaction...
February 6, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29415696/osteoporosis-knowledge-and-beliefs-in-diabetic-patients-a-cross-sectional-study-from-palestine
#10
Ghaith A Ishtaya, Yazan M Anabtawi, Sa'ed H Zyoud, Waleed M Sweileh
BACKGROUND: Osteoporosis is a potential metabolic complication of diabetes mellitus (DM). Therefore, patients with DM should have adequate osteoporosis knowledge and beliefs in order to get engaged in osteoporosis preventive behaviors. The objective of this study was to assess osteoporosis knowledge and beliefs among diabetic patients. METHODS: This was a cross sectional study carried out at Al-Makhfiah governmental primary healthcare unit in Nablus, Palestine from September 2016 to December 2016...
February 7, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29412817/glucose-dependent-insulinotropic-polypeptide-gip-receptor-antagonists-as-anti-diabetic-agents
#11
Lærke Smidt Gasbjerg, Maria Buur Nordskov Gabe, Bolette Hartmann, Mikkel Bring Christensen, Filip Krag Knop, Jens Juul Holst, Mette Marie Rosenkilde
Glucose-dependent insulinotropic polypeptide (GIP) is an intestinal hormone with a broad range of physiological actions. In the postprandial state, the hormone stimulates insulin secretion and during eu- and hypoglycemia, it stimulates glucagon secretion. In addition, GIP increases triacylglycerol (TAG) uptake in adipose tissue and decreases bone resorption. However, the importance of these actions in humans are not clearly understood as a specific GIP receptor (GIPR) antagonist - an essential tool to study GIP physiology - has been missing...
February 2018: Peptides
https://www.readbyqxmd.com/read/29412336/psychiatric-disorders-in-adolescents-with-type-1-diabetes-a-case-control-study
#12
Mireille C Almeida, Denise A Claudino, Ruth B Grigolon, Bacy Fleitlich-Bilyk, Angélica M Claudino
OBJECTIVES: To study the prevalence of psychiatric disorders in adolescents with and without type 1 diabetes, the factors associated with its presence, and to test the reliability of a screening tool for use in clinical settings. METHODS: Eighty-one adolescents were enrolled in this case-control study, including 36 diabetic participants and 45 controls. Clinical and sociodemographic data were collected and psychiatric symptoms and diagnoses were obtained from adolescents and their parents using a screening tool (Strengths & Difficulties Questionnaire) and a semi-structured interview (Development and Well-Being Assessment)...
February 1, 2018: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29408586/a-prospective-cohort-study-of-fetal-heart-rate-monitoring-deceleration-area-is-predictive-of-fetal-acidemia
#13
Alison G Cahill, Methodius G Tuuli, Molly J Stout, Julia D López, George A Macones
BACKGROUND: Intrapartum electronic fetal monitoring (EFM) is the most commonly used tool in obstetrics in the United States, however, which EFM patterns predict acidemia remains unclear. OBJECTIVE: This study was designed to describe the frequency of patterns seen in labor using modern nomenclature, and to test the hypothesis that visually interpreted patterns are associated with acidemia and morbidities in term infants. We further identified patterns prior to delivery, alone or in combination, predictive of acidemia and neonatal morbidity...
January 31, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29398809/a-study-of-platelet-indices-in-type-2-diabetes-mellitus-patients
#14
Kumari Shilpi, R M Potekar
Altered platelets have been reported in patients with diabetes mellitus and has been considered as a 'prothrombotic state' with enhanced platelet reactivity. They have been associated with increased risk of vascular complications in these patients. Platelet indices correlate with functional status of platelets and is an emerging risk factor of vascular complications in diabetes. The study was undertaken to know the efficacy of platelet analysis in assessing the prognosis of diabetes mellitus. A prospective hospital based study of platelet parameters MPV, PDW and P-LCR was carried out on 280 cases diagnosed with Type 2 diabetes Mellitus and 280 controls with normal blood glucose levels...
January 2018: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29383256/assessment-of-chronic-kidney-disease-using-skin-texture-as-a-key-parameter-for-south-indian-population
#15
Madhanlal Udhayarasu, Kalpana Ramakrishnan, Soundararajan Periasamy
Periodical monitoring of renal function, specifically for subjects with history of diabetic or hypertension would prevent them from entering into chronic kidney disease (CKD) condition. The recent increase in numbers may be due to food habits or lack of physical exercise, necessitates a rapid kidney function monitoring system. Presently, it is determined by evaluating glomerular filtration rate (GFR) that is mainly dependent on serum creatinine value and demographic parameters and ethnic value. Attempted here is to develop ethnic parameter based on skin texture for every individual...
December 2017: Healthcare Technology Letters
https://www.readbyqxmd.com/read/29370080/controversies-and-advances-in-gestational-diabetes-an-update-in-the-era-of-continuous-glucose-monitoring
#16
REVIEW
Marina P Carreiro, Anelise I Nogueira, Antonio Ribeiro-Oliveira
Diabetes in pregnancy, both preexisting type 1 or type 2 and gestational diabetes, is a highly prevalent condition, which has a great impact on maternal and fetal health, with short and long-term implications. Gestational Diabetes Mellitus (GDM) is a condition triggered by metabolic adaptation, which occurs during the second half of pregnancy. There is still a lot of controversy about GDM, from classification and diagnosis to treatment. Recently, there have been some advances in the field as well as recommendations from international societies, such as how to distinguish previous diabetes, even if first recognized during pregnancy, and newer diagnostic criteria, based on pregnancy outcomes, instead of maternal risk of future diabetes...
January 25, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29364280/study-of-in-vivo-glucose-metabolism-in-high-fat-diet-fed-mice-using-oral-glucose-tolerance-test-ogtt-and-insulin-tolerance-test-itt
#17
Csörsz Nagy, Elisa Einwallner
Obesity represents the most important single risk factor in the pathogenesis of type 2 diabetes, a disease which is characterized by a resistance to insulin-stimulated glucose uptake and a gross decompensation of systemic glucose metabolism. Despite considerable progress in the understanding of glucose metabolism, the molecular mechanisms of its regulation in health and disease remain under-investigated, while novel approaches to prevent and treat diabetes are urgently needed. Diet derived glucose stimulates the pancreatic secretion of insulin, which serves as the principal regulator of cellular anabolic processes during the fed-state and thus balances blood glucose levels to maintain systemic energy status...
January 7, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29363344/association-between-gestational-diabetes-and-biomarkers-a-role-in-diagnosis
#18
Sumaiya Adam, Carmen Pheiffer, Stephanie Dias, Paul Rheeder
BACKGROUND: We investigated the association between markers of insulin resistance, chronic inflammation, and adipokines and GDM. METHODS: In our case-cohort study in Johannesburg we included women with GDM and controls. We tested the ability of biomarkers to identify women at high risk of GDM. RESULTS: Of the 262 pregnant women, 83 (31.7%) had GDM. Women with GDM were heavier (p = 0.04) and had more clinical risk factors (p = 0.008)...
January 24, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29362618/correlation-between-the-montreal-cognitive-assessment-indonesian-version-moca-ina-and-the-mini-mental-state-examination-mmse-in-elderly
#19
Aldy Safruddin Rambe, Fasihah Irfani Fitri
BACKGROUND: As the rapid growth of the elderly population and the increased prevalence of Alezheimer's Disease and related disorders, there is an increasing need for effective cognitive screening. The Mini Mental State Examination (MMSE) is the most frequently used screening test of cognitive impairment because of its convenience. The Montreal Cognitive Assessment-Indonesian Version (MoCA-INA) has been validated and recently been used as a cognitive screening tool. OBJECTIVES: The aim of this study was to compare the MMSE and MoCA-INA scores and to determine the correlation between the MMSE and MoCA-INA scores in elderly...
December 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29362254/incremental-predictive-value-of-screening-for-anxiety-and-depression-beyond-current-type-2-diabetes-risk-models-a-prospective-cohort-study
#20
Evan Atlantis, Shima Ghassem Pour, Federico Girosi
OBJECTIVES: We sought to determine whether screening for anxiety and depression, an emerging risk factor for type 2 diabetes (T2D), adds clinically meaningful information beyond current T2D risk assessment tools. DESIGN: Prospective cohort. PARTICIPANTS AND SETTING: The 45 and Up Study is a large-scale prospective cohort of men and women aged 45 years and over, randomly sampled from the general population of New South Wales, Australia. 51 588 participants without self-reported diabetes at baseline (2006-2009) were followed up for approximately 3 years (2010)...
January 23, 2018: BMJ Open
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