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diabetes testing tools

Danilo T Perez-Rivera, Veronica L Torres-Torres, Abraham E Torres-Colon, Maytee Cruz-Aponte
Diabetes mellitus is a disease characterized by a range of metabolic complications involving an individual's blood glucose levels, and its main regulator, insulin. These complications can vary largely from person to person depending on their current biophysical state. Biomedical research day-by-day makes strides to impact the lives of patients of a variety of diseases, including diabetes. One large stride that is being made is the generation of techniques to assist physicians to ``personalize medicine''. From available physiological data, biological understanding of the system, and dimensional analysis, a differential equation-based mathematical model was built in a sequential matter, to be able to elucidate clearly how each parameter correlates to the patient's current physiological state...
October 1, 2016: Mathematical Biosciences and Engineering: MBE
Damilola D Adingupu, Suvi E Heinonen, Anne-Christine Andréasson, Mikael Brusberg, Andrea Ahnmark, Margareta Behrendt, Brendan Leighton, Ann-Cathrine Jönsson-Rylander
Aim. Models combining diabetes and atherosclerosis are important in evaluating the cardiovascular (CV) effects and safety of antidiabetes drugs in the development of treatments targeting CV complications. Our aim was to evaluate if crossing the heterozygous glucokinase knockout mouse (GK(+/-)) and hyperlipidemic mouse deficient in apolipoprotein E (ApoE(-/-)) will generate a disease model exhibiting a diabetic and macrovascular phenotype. Methods. The effects of defective glucokinase on the glucose metabolism and on the progression and regression of atherosclerosis on high-fat diets were studied in both genders of GK(+/-)ApoE(-/-) and ApoE(-/-) mice...
2016: Journal of Diabetes Research
Y H Cho, M E Craig, A S Januszewski, P Benitez-Aguirre, S Hing, A J Jenkins, K C Donaghue
AIM: To test the hypothesis that non-invasive skin autofluorescence, a measure of advanced glycation end products, would provide a surrogate measure of long-term glycaemia and be associated with early markers of microvascular complications in adolescents with Type 1 diabetes. METHODS: Forearm skin autofluorescence (arbitrary units) was measured in a cross-sectional study of 135 adolescents with Type 1 diabetes [mean ± sd age 15.6 ± 2.1 years, diabetes duration 8...
October 22, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
Swarupa Kancherla, William J Kohler, Yolandi van der Merwe, Kevin C Chan
Visual function has been shown to deteriorate prior to the onset of retinopathy in some diabetic patients and experimental animal models. This suggests the involvement of the brain's visual system in the early stages of diabetes. In this study, we tested this hypothesis by examining the integrity of the visual pathway in a diabetic rat model using in vivo multi-modal magnetic resonance imaging (MRI). Ten-week-old Sprague-Dawley rats were divided into an experimental diabetic group by intraperitoneal injection of 65 mg/kg streptozotocin in 0...
2016: PloS One
Helena Lenasi, Markos Klonizakis
Diabetes mellitus (DM) is associated with cardiovascular complications. Impairment of glycemic control induces noxious glycations, an increase in oxydative stress and dearangement of various metabolic pathways. DM leads to dysfunction of micro and macrovessels, connected to metabolic, endothelial and autonomic nervous system. Thus, assessing vascular reactivity might be one of the clinical tools to evaluate the impact of harmful effects of DM and potential benefit of treatment; skin and skeletal muscle microcirculation have usually been tested...
October 18, 2016: Clinical Hemorheology and Microcirculation
Kristen L Marjama, JoAnn S Oliver, Jennifer Hayes
IN BRIEF This article describes a study to gain insight into the utility and perceived feasibility of the American Diabetes Association's Diabetes Risk Test (DRT) implemented by nurse practitioners (NPs) in the retail clinic setting. The DRT is intended for those without a known risk for diabetes. Researchers invited 1,097 NPs working in the retail clinics of a nationwide company to participate voluntarily in an online questionnaire. Of the 248 NPs who sent in complete responses, 114 (46%) indicated that they used the DRT in the clinic...
October 2016: Clinical Diabetes: a Publication of the American Diabetes Association
Peter Rijnbeek
Massive numbers of electronic health records are currently being collected globally, including structured data in the form of diagnoses, medications, laboratory test results, and unstructured data contained in clinical narratives. This opens unprecedented possibilities for research and ultimately patient care. However, actual use of these databases in a multi-center study is severely hampered by a variety of challenges, e.g., each database has a different database structure and uses different terminology systems...
September 2016: Journal of Hypertension
Aletta Schutte
Cardiovascular risk prediction has developed significantly during recent years, as cardiovascular disease prevention guidelines recommend risk scores to identify patients at high and low risk. Where novel biomarkers were identified in recent years, it is simply impractical and expensive to perform laboratory testing as part of screening for non-communicable diseases in low- and middle-income countries. As part of a broader consortium we compared the ranking performance of a simple, non-laboratory-based risk score to laboratory-based scores in various South African populations...
September 2016: Journal of Hypertension
Joseph M Czerniecki, Aaron P Turner, Rhonda M Williams, Mary Lou Thompson, Greg Landry, Kevin Hakimi, Rebecca Speckman, Daniel C Norvell
OBJECTIVE: The objective of this study was the development of AMPREDICT-Mobility, a tool to predict the probability of independence in either basic or advanced (iBASIC or iADVANCED) mobility 1 year after dysvascular major lower extremity amputation. METHODS: Two prospective cohort studies during consecutive 4-year periods (2005-2009 and 2010-2014) were conducted at seven medical centers. Multiple demographic and biopsychosocial predictors were collected in the periamputation period among individuals undergoing their first major amputation because of complications of peripheral arterial disease or diabetes...
October 14, 2016: Journal of Vascular Surgery
Wenbin Li, Lili Zhang, Jianyu Hao, Yongdong Wu, Di Lu, Haiying Zhao, Zhenjie Wang, Tianming Xu, Hong Yang, Jiaming Qian, Jingnan Li
The Asia-Pacific Colorectal Screening (APCS) score is a risk-stratification tool that helps predict the risk for advanced colorectal neoplasia (ACN) in asymptomatic Asian populations, but has not yet been assessed for its validity of use in Mainland China.The aim of the study was to assess the validity of APCS score in asymptomatic Chinese population, and to identify other risk factors associated with ACN.Asymptomatic subjects (N = 1010) who underwent colonoscopy screening between 2012 and 2014 in Beijing were enrolled...
October 2016: Medicine (Baltimore)
Kyoungsan Seo, Misoon Song, Suyoung Choi, Se-An Kim, Sun Ju Chang
AIM: The purpose of this study was to develop the Diabetes Self-Management Behavior for Older Koreans (DSMB-O). This scale is based on the seven relevant domains that have been identified by the American Association of Diabetes Educators (AADE) and is adjusted for sociocultural and age-related characteristics. METHODS: Four phases were used to develop of the DSMB-O as a criterion-referenced measure. In phases 1 and 2, the DSMB-O adopted the AADE's seven domains and established a self-report questionnaire using a small number of items that are applicable to older Koreans...
October 13, 2016: Japan Journal of Nursing Science: JJNS
Melanie Tomintz, Bernhard Kosar, Graham Clarke
BACKGROUND: Reducing the smoking population is still high on the policy agenda, as smoking leads to many preventable diseases, such as lung cancer, heart disease, diabetes, and more. In Austria, data on smoking prevalence only exists at the federal state level. This provides an interesting overview about the current health situation, but for regional planning authorities these data are often insufficient as they can hide pockets of high and low smoking prevalence in certain municipalities...
October 7, 2016: International Journal of Health Geographics
Liz Graham, Judy Wright, Rebecca Walwyn, Amy M Russell, Louise Bryant, Amanda Farrin, Allan House
BACKGROUND: Reporting adherence to intervention delivery and uptake is a detailed way of describing what was actually delivered and received, in comparison to what was intended. Measuring and reporting adherence is not routinely done well in complex interventions. The OK Diabetes trial (ISRCTN41897033) aimed to develop and subsequently test the feasibility of implementing a supported self-management intervention in adults with a learning disability and type 2 diabetes. A key study objective was to develop a measure of adherence to the intervention...
October 6, 2016: BMC Medical Research Methodology
Tina Karjalainen, Martin Adiels, Lena Björck, Marie-Therèse Cooney, Ian Graham, Joep Perk, Annika Rosengren, Stefan Söderberg, Mats Eliasson
BACKGROUND: Risk prediction models for cardiovascular death are important for providing advice on lifestyle and in decision-making regarding primary preventive drug treatment. The latest Swedish version of the Systematic COronary Risk Evaluation (SCORE 2015) has yet not been tested in the population. OBJECTIVE: The objective of this study was to estimate the prevalence of high and very high risk of fatal cardiovascular disease (CVD) of the current population according to 2015 SCORE Sweden and to evaluate the predictive accuracy of the 2003 Swedish version of SCORE (2003 SCORE Sweden) and 2015 SCORE Sweden in a population with declining CVD mortality...
October 5, 2016: European Journal of Preventive Cardiology
Ce Tan, Yutaka Sasagawa, Ken-Ichi Kamo, Takehiro Kukitsu, Sayaka Noda, Kazuma Ishikawa, Natsumi Yamauchi, Takashi Saikawa, Takanori Noro, Hajime Nakamura, Fumihiko Takahashi, Fumihiro Sata, Mitsuhiro Tada, Yasuo Kokai
OBJECTIVES: To prevent the onset of lifestyle-related diseases associated with metabolic syndrome (MetS) in Japan, research into the development of a useful screening method is strongly desired. We developed a new screening questionnaire (JAMRISC) utilizing a logistic regression model and evaluated its ability to predict the development of MetS, type 2 diabetes and other lifestyle-related diseases in Japanese populace. METHODS: JAMRISC questionnaire was sent to 1,850 individuals in Rumoi, a small city in Hokkaido...
October 3, 2016: Environmental Health and Preventive Medicine
James F Graumlich, Huaping Wang, Anna Madison, Michael S Wolf, Darren Kaiser, Kumud Dahal, Daniel G Morrow
Among patients with various levels of health literacy, the effects of collaborative, patient-provider, medication-planning tools on outcomes relevant to self-management are uncertain. Objective. Among adult patients with type II diabetes mellitus, we tested the effectiveness of a medication-planning tool (Medtable™) implemented via an electronic medical record to improve patients' medication knowledge, adherence, and glycemic control compared to usual care. Design. A multicenter, randomized controlled trial in outpatient primary care clinics...
2016: Journal of Diabetes Research
Sarah Cheng, Theodore Leng
BACKGROUND AND OBJECTIVES: A method of identifying retinal vascular microaneurysms (MAs) in nonproliferative diabetic retinopathy (NPDR) using swept-source optical coherence tomography (SS-OCT). PATIENTS AND METHODS: SS-OCT images were acquired in 17 eyes with NPDR using prototype SS-OCT device and fluorescein angiography (FA) images were obtained simultaneously. MAs identified on SS-OCT slabs were correlated to MAs identified on FA. RESULTS: MAs were identified in SS-OCT slabs in 15/17 eyes, resulting in NPDR diagnosis rate of 88%...
2016: Clinical Ophthalmology
Kumarasinghe Arachchigey Sriyani, Nalika Gunawardena, Sudharshani Wasalathanthri, Priyadarshika Hettiarachchi
PURPOSE: To validate the Cardiff Wound Impact Schedule (CWIS) to assess the health-related quality of life (HRQoL) of Sri Lankan patients with diabetic leg and foot ulcers. METHODS: English version of CWIS was examined for cultural compatibility, translated into Sinhala and pretested. The Sinhala version was administered in parallel with the validated Sinhala version of SF-36 by an interviewer to all patients (n = 140) at baseline to determine the construct validity...
September 2016: Asian Nursing Research
Romil Parikh, Girish Bakhshi, Madhushree Naik, Bhargav Gaikwad, Kavita Jadhav, Mukund Tayade
BACKGROUND: Some of the relatively newer, more efficacious, and potent topical wound dressing solutions include tetrachlorodecaoxide and super-oxidised solution. This study compares the efficacy and safety of these two drugs. METHODS: This is a block-randomised, double blind, parallel-arm, post-marketing study. One hundred fifty patients with ulcers (75 blocks uniform for sex, ulcer aetiology, diabetes mellitus, and wound area score) were randomised into the two treatment arms...
September 2016: Archives of Plastic Surgery
Larske M Soepnel, Shane A Norris, Verena J M M Schrier, Joyce L Browne, Marcus J Rijken, Glenda Gray, Kerstin Klipstein-Grobusch
OBJECTIVES: The widespread, chronic use of antiretroviral therapy (ART) raises questions concerning the metabolic consequences of HIV infection and treatment. Antiretroviral therapy, and specifically protease inhibitors (PIs), has been associated with hyperglycaemia. As pregnant women are vulnerable to development of hyperglycaemia, the objective of this study was to explore existing literature on the relationship between HIV infection, HIV treatment and gestational diabetes mellitus (GDM)...
September 24, 2016: AIDS
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