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https://www.readbyqxmd.com/read/29671539/evaluation-of-suspected-dementia
#1
Nathan Falk, Ariel Cole, T Jason Meredith
Dementia is a significant and costly health condition that affects 5 million adults and is the fifth leading cause of death among Americans older than 65 years. The prevalence of dementia will likely increase in the future because the number of Americans older than 65 years is expected to double by 2060. Risk factors for dementia include age; family history of dementia; personal history of cardiovascular disease, cerebrovascular disease, diabetes mellitus, or midlife obesity; use of anticholinergic medications; apolipoprotein E4 genotype; and lower education level...
March 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29669707/a-web-based-decision-tool-to-improve-contraceptive-counseling-for-women-with-chronic-medical-conditions-protocol-for-a-mixed-methods-implementation-study
#2
Justine P Wu, Laura J Damschroder, Michael D Fetters, Brian J Zikmund-Fisher, Benjamin F Crabtree, Shawna V Hudson, Mack T Ruffin Iv, Juliana Fucinari, Minji Kang, L Susan Taichman, John W Creswell
BACKGROUND: Women with chronic medical conditions, such as diabetes and hypertension, have a higher risk of pregnancy-related complications compared with women without medical conditions and should be offered contraception if desired. Although evidence based guidelines for contraceptive selection in the presence of medical conditions are available via the United States Medical Eligibility Criteria (US MEC), these guidelines are underutilized. Research also supports the use of decision tools to promote shared decision making between patients and providers during contraceptive counseling...
April 18, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29669705/diabetes-related-behavior-change-knowledge-transfer-to-primary-care-practitioners-and-patients-implementation-and-evaluation-of-a-digital-health-platform
#3
Samina Abidi, Michael Vallis, Helena Piccinini-Vallis, Syed Ali Imran, Syed Sibte Raza Abidi
BACKGROUND: Behavioral science is now being integrated into diabetes self-management interventions. However, the challenge that presents itself is how to translate these knowledge resources during care so that primary care practitioners can use them to offer evidence-informed behavior change support and diabetes management recommendations to patients with diabetes. OBJECTIVE: The aim of this study was to develop and evaluate a computerized decision support platform called "Diabetes Web-Centric Information and Support Environment" (DWISE) that assists primary care practitioners in applying standardized behavior change strategies and clinical practice guidelines-based recommendations to an individual patient and empower the patient with the skills and knowledge required to self-manage their diabetes through planned, personalized, and pervasive behavior change strategies...
April 18, 2018: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29662686/patterns-of-physical-activity-in-sedentary-older-individuals-with-type-2-diabetes
#4
Pearl G Lee, Jinkyung Ha, Caroline S Blaum, Kimberlee Gretebeck, Neil B Alexander
Background: The Community Healthy Activities Model Program for Seniors (CHAMPS) survey, summarized into weekly caloric expenditures, is a common physical activity (PA) assessment tool among older adults. Specific types of PA reported in the CHAMPS have not been systematically analyzed. We applied latent class analysis to identify the patterns of PA among sedentary older adults with diabetes reported in the CHAMPS survey. Methods: Latent class models of PA were identified using the CHAMPS survey data reported by 115 individuals aged ≥60 years with type 2 diabetes whom volunteered for a clinical study of PA...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29655463/proteomics-for-biomarker-identification-and-clinical-application-in-kidney-disease
#5
Lin Chen, Wei Su, Hua Chen, Dan-Qian Chen, Ming Wang, Yan Guo, Ying-Yong Zhao
Treatment effectiveness for kidney disease is limited by lack of accuracy, sensitivity, specificity of diagnostic, prognostic, and therapeutic biomarkers. The gold standard test renal biopsy along with serum creatinine and proteinuria is often necessary to establish a diagnosis, particularly in glomerular disease. Proteomics has become a powerful tool for novel biomarker discovery in kidney disease. Novel proteomics offer earlier and more accurate diagnosis of renal pathology than possible with traditional biomarkers such as serum creatinine and urine protein...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29629449/post-hoc-support-vector-machine-learning-for-impedimetric-biosensors-based-on-weak-protein-ligand-interactions
#6
Y Rong, A V Padron, K J Hagerty, N Nelson, S Chi, N O Keyhani, J Katz, S P A Datta, C Gomes, E S McLamore
Impedimetric biosensors for measuring small molecules based on weak/transient interactions between bioreceptors and target analytes are a challenge for detection electronics, particularly in field studies or in the analysis of complex matrices. Protein-ligand binding sensors have enormous potential for biosensing, but achieving accuracy in complex solutions is a major challenge. There is a need for simple post hoc analytical tools that are not computationally expensive, yet provide near real time feedback on data derived from impedance spectra...
April 9, 2018: Analyst
https://www.readbyqxmd.com/read/29617485/-hypertriglyceridemic-waist-phenotype-associated-factors-and-comparison-with-other-cardiovascular-and-metabolic-risk-indicators-in-the-elsa-brasil-study
#7
Roberta Souza Freitas, Maria de Jesus Mendes da Fonseca, Maria Inês Schmidt, Maria Del Carmen Bisi Molina, Maria da Conceição Chagas de Almeida
This study's objectives were to estimate the prevalence of hypertriglyceridemic waist (HTW) phenotype in participants in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), identify associated risk factors, and compare with other cardiovascular and metabolic risk indicators. This was a cross-sectional study with baseline data from a cohort of public employees. HTW is defined as the simultaneous presence of increased waist circumference (WC) (≥ 80cm for women, ≥ 90cm for men according to the International Diabetes Federation - IDF; and ≥ 88cm for women, ≥ 102cm for men according to the U...
March 29, 2018: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29615107/development-and-validation-of-a-tool-to-assess-knowledge-of-healthy-lifestyles-in-early-grade-school-children
#8
Salim R Surani, Sean Hesselbacher, Zoya Surani, Moinuddin Mokhasi, Saherish S Surani, Jose Guardiola, Lauren Quisenberry, Sara S Surani
OBJECTIVE: Healthy habits during childhood has been of prime importance. We aimed to gather baseline information about health habits from children in kindergarten and first grade (typically ages 5-7). Our objectives were to validate the questionnaire in assessing health habits, as well as the electronic audience response system, iClicker (MPS, Gordonsville, VA), in this age group. RESULTS: The questionnaire completed by 75 kindergarteners and 66 first graders. For the first graders, questions involving healthy choices were answered correctly 78% of the time (range 8-94%) and had 84% agreement on repeat testing (range 64-93%)...
April 3, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29614684/novel-lipidized-analog-of-prolactin-releasing-peptide-improves-memory-impairment-and-attenuates-hyperphosphorylation-of-tau-protein-in-a-mouse-model-of-tauopathy
#9
Andrea Popelová, Veronika Pražienková, Barbora Neprašová, Barbora Judita Kasperová, Lucie Hrubá, Martina Holubová, Jana Zemenová, David Blum, Blanka Železná, Marie-Christine Galas, Jaroslav Kuneš, Lenka Maletínská
Obesity and type 2 diabetes mellitus (T2DM) were characterized as risk factors for Alzheimer's disease (AD) development. Subsequently, T2DM drugs, such as liraglutide, were proven to be neuroprotective compounds attenuating levels of amyloid deposits, and tau hyperphosphorylation, both hallmarks of AD. The central anorexigenic effects of liraglutide inspired us to examine the potential neuroprotective effects of palm11-PrRP31, a strong anorexigenic analog with glucose-lowering properties, in THY-Tau22 mice overexpressing mutated human tau, a model of AD-like tau pathology...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29600505/the-economic-burden-of-insulin-related-hypoglycemia-in-adults-with-diabetes-an-analysis-from-the-perspective-of-the-italian-healthcare-system
#10
Witesh Parekh, Sophie E Streeton, James Baker-Knight, Roberta Montagnoli, Paolo Nicoziani, Giulio Marchesini
INTRODUCTION: The aim of this analysis was to estimate the cost of insulin-related hypoglycemia in adult patients with diabetes in Italy using the Local Impact of Hypoglycemia Tool (LIHT), and to explore the effect of different hypoglycemia rates on budget impact. METHODS: Direct costs and healthcare resource utilization were estimated for severe and non-severe hypoglycemic episodes in Italy and applied to the population of adults with type 1 diabetes (T1DM) and type 2 diabetes (T2DM) and their corresponding hypoglycemia episode rates (0...
March 29, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29596953/measuring-the-reliability-and-validity-of-the-greek-edition-of-the-diabetes-quality-of-life-brief-clinical-inventory
#11
Maria Rekleiti, Kyriakos Souliotis, Pavlos Sarafis, Maria Tsironi, Ioannis Kyriazis
BACKGROUND: The present study focuses on studying the validity and reliability of the Greek edition of DQOL-BCI. DQOL-BCI includes 15 questions-elements that are evaluated on a 5-grade scale like Likert and two general form-shapes. METHODS: The translation process was conducted in conformity with the guidelines of EuroQol group. A non-random sample of 65 people-patients diagnosed with diabetes I and II was selected. The questionnaire that was used to collect the data was the translated version of DQOL-BCI, and included the demographic characteristics of the interviewees...
March 26, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29594432/novel-and-recurrent-variants-in-avpr2-in-19-families-with-x-linked-congenital-nephrogenic-diabetes-insipidus
#12
Shivani Joshi, Helene Kvistgaard, Konstantinos Kamperis, Mia Færch, Søren Hagstrøm, Niels Gregersen, Søren Rittig, Jane Hvarregaard Christensen
Congenital nephrogenic diabetes insipidus (CNDI) is characterized by the reduced ability of renal collecting duct cells to reabsorb water in response to the antidiuretic effect of vasopressin. Chronic polyuria and polydipsia are the hallmarks of the disease. Approximately 90% of all patients with CNDI have X-linked inherited disease caused by variants in the arginine vasopressin receptor 2 (AVPR2) gene. We present genetic findings in 34 individuals from 19 kindreds including one or more family members with CNDI...
March 28, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29593644/autonomic-neuropathy-a-prospective-cohort-study-of-symptoms-and-e-i-ratio-in-normal-glucose-tolerance-impaired-glucose-tolerance-and-type-2-diabetes
#13
Malin Zimmerman, Kaveh Pourhamidi, Olov Rolandsson, Lars B Dahlin
Background: Autonomic neuropathy in diabetes, in addition to causing a range of symptoms originating from the autonomic nervous system, may increase cardiovascular morbidity. Our aim was to study the progression of autonomic neuropathy, based on symptom score and evaluation of an autonomic test, in persons with normal and impaired glucose tolerance and in patients with type 2 diabetes (T2D). Methods: Participants were recruited in 2003/2004 with a follow-up in 2014...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29575824/complex-bayesian-modeling-workflows-encoding-and-execution-made-easy-with-a-novel-winbugs-plugin-of-the-drug-disease-model-resources-interoperability-framework
#14
Cristiana Larizza, Elisa Borella, Lorenzo Pasotti, Palma Tartaglione, Mike Smith, Stuart Moodie, Paolo Magni
The Drug Disease Model Resources (DDMoRe) Interoperability Framework (IOF) enables pharmacometric model encoding and execution via Model Description Language (MDL) and R language, through the ddmore package. Through its components and converter plugins, the IOF can execute pharmacometric tasks using different target tools, starting from a single MDL-encoded model. In this article, we present the WinBUGS plugin and show how its integration in the IOF enables an easy implementation of complex Bayesian workflows...
March 25, 2018: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/29568804/screening-for-diabetes-risk-using-integrated-dental-and-medical-electronic-health-record-data
#15
A Acharya, B Cheng, R Koralkar, B Olson, I B Lamster, C Kunzel, E Lalla
Undiagnosed diabetes and prediabetes present a serious public health challenge. We previously reported that data available in the dental setting can serve as a tool for early dysglycemia identification in a primarily Hispanic, urban population. In the present study, we sought to determine how the identification approach can be recalibrated to detect diabetes or prediabetes in a White, rural cohort and whether an integrated dental-medical electronic health record (iEHR) offers further value to the process. We analyzed iEHR data from the Marshfield Clinic, a health system providing care in rural Wisconsin, for dental patients who were ≥21 y of age, reported that they had never been told they had diabetes, had an initial periodontal examination of at least 2 quadrants, and had a glycemic assessment within 3 mo of that examination...
April 2018: JDR Clinical and Translational Research
https://www.readbyqxmd.com/read/29567849/diagnostic-accuracy-of-self-administered-urine-glucose-test-strips-as-a-diabetes-screening-tool-in-a-low-resource-setting-in-cambodia
#16
Helen L Storey, Maurits H van Pelt, Socheath Bun, Frances Daily, Tina Neogi, Matthew Thompson, Helen McGuire, Bernhard H Weigl
OBJECTIVE: Screening for diabetes in low-resource countries is a growing challenge, necessitating tests that are resource and context appropriate. The aim of this study was to determine the diagnostic accuracy of a self-administered urine glucose test strip compared with alternative diabetes screening tools in a low-resource setting of Cambodia. DESIGN: Prospective cross-sectional study. SETTING: Members of the Borey Santepheap Community in Cambodia (Phnom Penh Municipality, District Dangkao, Commune Chom Chao)...
March 22, 2018: BMJ Open
https://www.readbyqxmd.com/read/29566707/impact-of-hypoglycemic-episodes-on-health-related-quality-of-life-of-type-2-diabetes-mellitus-patients-development-and-validation-of-a-specific-qolhypo-%C3%A2-questionnaire
#17
Domingo Orozco-Beltrán, Sara Artola, Margarida Jansà, Martin Lopez de la Torre-Casares, Eva Fuster
BACKGROUND: Hypoglycemia is a limiting factor to achieving optimal glycemic control in patients with type-2 diabetes mellitus (T2DM), increasing risk of death and complications, reducing health-related quality of life (HRQoL) and work productivity and increasing healthcare costs. The study's primary objective was to develop and validate a specific questionnaire to assess the impact of hypoglycemia on the HRQoL of T2DM patients (QoLHYPO© questionnaire). METHODS: A two-phase multicenter prospective, longitudinal, observational, epidemiologic study of consecutively enrolled patients, not involving any drug, was conducted: In phase 1 (questionnaire development), patients who had given their written informed consent, who were at least 30 years of age, had been diagnosed with T2DM at least 5 years prior, had an HbA1c test in the previous 3 months, and a hypoglycemic episode in the previous 6 months were included...
March 23, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29559205/a-clinical-evaluation-of-placental-growth-factor-in-routine-practice-in-high-risk-women-presenting-with-suspected-pre-eclampsia-and-or-fetal-growth-restriction
#18
L Ormesher, E D Johnstone, E Shawkat, A Dempsey, C Chmiel, E Ingram, L E Higgins, J E Myers
OBJECTIVE: To evaluate the use of plasma Placental Growth Factor (PlGF), recommended by the recent NICE guidance, in women with suspected pre-eclampsia (PE) and/or fetal growth restriction (FGR). STUDY DESIGN: Non-randomised prospective clinical evaluation study in high-risk antenatal clinics in a tertiary maternity unit. METHODS: PlGF testing was performed in addition to routine clinical assessment in 260 women >20 weeks' gestation with chronic disease (hypertension, renal disease ± diabetes) with a change in maternal condition or in women with suspected FGR to determine the impact on clinical management...
March 13, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29553838/preliminary-evaluation-of-foetal-liver-volume-by-three-dimensional-ultrasound-in-women-with-gestational-diabetes-mellitus
#19
Gülşah İlhan, Hüseyin Gültekin, Ayça Kubat, Ayse Filiz Gokmen Karasu, Emre Sinan Güngör, Galip Ali Zebitay, Fatma Ferda Verit Atmaca
The aim of the study was to assess the standard foetal biometric measurements and foetal liver volume (FLV) in pregnancies complicated by gestational diabetes mellitus (GDM) at the time of GDM screening and to compare the results with foetuses in normal pregnancies. Ninety-seven pregnant women with normal singleton uncomplicated pregnancies between 24 and 28 weeks of gestation were allocated into GDM (+) (n: 33) and GDM (-) (n: 64) groups based on their 75 g oral glucose tolerance test results. Foetal biometric measurements and FLV measurements of the groups were compared...
March 19, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29551261/-reliability-and-validity-of-a-spanish-version-of-the-8-item-morisky-medication-adherence-scale-mmas-8-in-patients-with-type-2-diabetes-mellitus-taking-oral-antidiabetic-drugs
#20
Elisabet Esquivel-Prados, Elisa Pareja-Martínez, Joanna C Moullin, Fernando Martínez-Martínez, José P García-Corpas
OBJECTIVE: To assess the reliability and validity of a Spanish translation of the 8-item Morisky Medication Adherence Scale (MMAS-8) in people with Type 2 diabetes mellitus taking oral antidiabetic medications. DESIGN: A cross sectional study. LOCATION: Community pharmacies in Granada (Spain). PARTICIPANTS: 124 patients with Type 2 diabetes mellitus taking oral antidiabetic medications. MAIN MEASUREMENTS: Eligible participants had a face-to-face interview to administer the translated MMAS-8 into spanish and measure their glycosylated haemoglobin (HbA1c) level using the A1CNow+® Multi-Test A1C system...
March 15, 2018: Atencion Primaria
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