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https://www.readbyqxmd.com/read/28088237/association-between-diabetes-mellitus-and-multi-drug-resistant-tuberculosis-a-protocol-for-a-systematic-review-and-meta-analysis
#1
Balewgizie Sileshi Tegegne, Tesfa Dejenie Habtewold, Melkamu Merid Mengesha, Johannes G M Burgerhof
INTRODUCTION: Multi-drug-resistant tuberculosis (MDR-TB) has emerged as a challenge to global tuberculosis (TB) control and remains a major public health concern in many countries. Diabetes mellitus (DM) is an increasingly recognized comorbidity that can both accelerate TB disease and complicate its treatment. The aim of this study is to summarize available evidence on the association of DM and MDR-TB among TB patients and to provide a pooled estimate of risks. METHODS: All studies published in English before October 2016 will be searched using comprehensive search strings through PubMed, EMBASE, Web of Science, and WHO Global Health Library databases which have reported the association of DM and MDR-TB in adults with TB (age > =15)...
January 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28071894/noninvasive-monitoring-of-blood-glucose-with-raman-spectroscopy
#2
Rishikesh Pandey, Santosh Kumar Paidi, Tulio A Valdez, Chi Zhang, Nicolas Spegazzini, Ramachandra Rao Dasari, Ishan Barman
The successful development of a noninvasive blood glucose sensor that can operate reliably over sustained periods of time has been a much sought after but elusive goal in diabetes management. Since diabetes has no well-established cure, control of elevated glucose levels is critical for avoiding severe secondary health complications in multiple organs including the retina, kidney and vasculature. While fingerstick testing continues to be the mainstay of blood glucose detection, advances in electrochemical sensing-based minimally invasive approaches have opened the door for alternate methods that would considerably improve the quality of life for people with diabetes...
January 10, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28064163/predicting-albuminuria-response-to-spironolactone-treatment-with-urinary-proteomics-in-patients-with-type-2-diabetes-and-hypertension
#3
Morten Lindhardt, Frederik Persson, Christina Oxlund, Ib A Jacobsen, Petra Zürbig, Harald Mischak, Peter Rossing, Hiddo J L Heerspink
BACKGROUND: The mineralocorticoid receptor antagonist spironolactone significantly reduces albuminuria in patients with diabetes. Prior studies have shown large between-patient variability in albuminuria treatment response. We previously developed and validated a urinary proteomic classifier that predicts onset and progression of chronic kidney disease. Here, we tested whether the proteomic classifier based on 273 urinary peptides (CKD273) predicts albuminuria response to spironolactone treatment...
January 7, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28063875/clinical-worthlessness-of-genetic-prediction-of-common-forms-of-diabetes-mellitus-and-related-chronic-complications-a-position-statement-of-the-italian-society-of-diabetology
#4
REVIEW
R Buzzetti, S Prudente, M Copetti, M Dauriz, S Zampetti, M Garofolo, G Penno, V Trischitta
AIM: We are currently facing several attempts aimed at marketing genetic data for predicting multifactorial diseases, among which diabetes mellitus is one of the more prevalent. The present document primarily aims at providing to practicing physicians a summary of available data regarding the role of genetic information in predicting diabetes and its chronic complications. DATA SYNTHESIS: Firstly, general information about characteristics and performance of risk prediction tools will be presented in order to help clinicians to get acquainted with basic methodological information related to the subject at issue...
August 26, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28060686/-diabetes-knowledge-test-feasibility-in-portugal
#5
Constança Azevedo, Luiz Santiago
INTRODUCTION: Given the rising incidence of type 2 diabetes and taking into account that much of its control depends on the patient's attitude towards his illness, loomed the need to equip health professionals with capable tools to determine the educational needs of their patients, allowing a more personalized intervention to correct habits that could be harmful to the diabetics' health. OBJECTIVE: Verify the Diabetes Knowledge Test reliability in Portugal. Analysis of socio-demographic and pathologic variables' correlation with the number of correct answers in the test...
September 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28059156/genetic-screening-in-arterial-hypertension
#6
REVIEW
Gian Paolo Rossi, Giulio Ceolotto, Brasilina Caroccia, Livia Lenzini
Studies involving adoptive families and twins have demonstrated the genetic basis of hypertension and shown that genetic factors account for about 40% of the variance in blood pressure among individuals. Arterial hypertension is genetically complex: multiple genes influence the blood pressure phenotype through allelic effects from single genes and gene-gene interactions. Moreover, environmental factors also modify the blood pressure phenotype. This complexity explains why the identification of the underlying genes has not been as successful in hypertension as in other diseases (such as type 1 and type 2 diabetes mellitus)...
January 6, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28053822/bulbocavernosus-reflex-test-for-diagnosis-of-pudendal-nerve-injury-in-female-patients-with-diabetic-neurogenic-bladder
#7
Xiaoting Niu, Xun Wang, Huanjie Huang, Peiqi Ni, Yuanshao Lin, Bei Shao
The study was designed to investigate the clinical application and significance of the bulbocavernosus reflex (BCR) test for diagnosing diabetic neurogenic bladder (DNB) in female subjects. In this study, 68 female patients with DNB and 40 female normal controls were subjected to a nerve conduction study (NCS) of all four limbs and the BCR test. The data were analyzed and compared, and the corresponding diagnostic sensitivities were discussed. Mean BCR latency for female DNB patients was significantly prolonged, compared to that of the control group, suggesting pudendal nerve injuries in female DNB patients...
December 2016: Aging and Disease
https://www.readbyqxmd.com/read/28052205/salivary-alkaline-phosphatase-as-a-noninvasive-marker-for-periodontal-disease-in-children-with-uncontrolled-type-1-diabetes-mellitus
#8
Srirangarajan Sridharan, Paruchuri Sravani, Aparna Satyanarayan, K Kiran, Varun Shetty
OBJECTIVE: The aim of this pilot study was to determine whether salivary alkaline phosphatase levels can be a non invasive marker for early inflammatory periodontal disease in children with uncontrolled type 1 diabetes mellitus. STUDY DESIGN: 10 healthy children (group 1), 10 children with recently diagnosed type 1 diabetes mellitus (group 2) and 10 children with type 1 diabetes mellitus for more than 4 years (group 3) were recruited for the study. All three groups were matched for age, gender and socioeconomic status...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28048716/su-f-j-04-automated-detection-of-diabetic-retinopathy-using-deep-convolutional-neural-networks
#9
Kele Xu, Li Zhu, Ruixing Wang, Chang Liu, Yi Zhao
PURPOSE: In this work, we explore to use very deep convolutional neural network (CNN) for the automatic classification of diabetic retinopathy using color fundus image. METHODS: We apply translation, stretching, rotation and flipping to the labeled dataset. The original number of labeled-frames is 3000, while after augmentations, 6000 frames with labels are used for the CNN training task. Several different CNN architectures have been proposed and tested. The architecture of our network contains 18 layers with parameters, consists of 12 convolutional layers, some of which followed by max-pooling layers, and two fully connected layers...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042735/medication-regimen-complexity-and-a1c-goal-attainment-in-underserved-adults-with-type-2-diabetes
#10
Alicia Yeh, Bijal Shah-Manek, Kajua B Lor
BACKGROUND: From 2009 to 2012, 51.8% of American adults with diabetes had a hemoglobin A1C (A1C) >7.0%. The complexity of antidiabetic medication regimens may have an impact on glycemic control. OBJECTIVE: The primary objective was to test the hypothesis that higher diabetes-specific medication regimen complexity index (MRCI) was associated with lower attainment of A1C goal <7.0% in an underserved, predominantly Hispanic population of adults with type 2 diabetes...
February 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28029212/a-new-model-to-estimate-insulin-resistance-via-clinical-parameters-in-adults-with-type-1-diabetes
#11
Xueying Zheng, Bin Huang, Sihui Luo, Daizhi Yang, Wei Bao, Jin Li, Bin Yao, Jianping Weng, Jinhua Yan
AIMS/HYPOTHESIS: Insulin resistance (IR) is a risk factor to assess the development of micro- and macro-vascular complications in type 1 diabetes (T1D). However, diabetes management in adults with T1D is limited by the difficulty of lacking simple and reliable method to estimate IR. The aim of this study was to develop a new model to estimate IR via clinical parameters in adults with T1D. METHODS: A total of 36 adults with adulthood onset T1D (n = 20) or childhood onset T1D (n = 16) were recruited by quota sampling...
December 28, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28028392/effect-of-pseudocereal-based-breakfast-meals-on-the-first-and-second-meal-glucose-tolerance-in-healthy-and-diabetic-subjects
#12
Shreef G N Gabrial, Marie-Christine R Shakib, Gamal N Gabrial
BACKGROUND: Many studies have indicated that the incidence of serious diabetic complications may be reduced through strict glycemic control. A low glycemic index diet is one tool to improve insulin resistance and improve glycemic control in type 2 diabetes mellitus (T2DM). AIM: The objective was to study the effect of pseudocereals-based breakfasts (quinoa and buckwheat) on glucose variations at first meal (breakfast) and second meal (standardised lunch) in healthy and diabetic subjects...
December 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28017910/nutrition-knowledge-and-mediterranean-diet-adherence-in-the-southeast-united-states-validation-of-a-field-based-survey-instrument
#13
Mary Rose Bottcher, Patricia Z Marincic, Katie L Nahay, Brittany E Baerlocher, Amy W Willis, Jieun Park, Philippe Gaillard, Michael W Greene
The Mediterranean diet (MD) can reduce chronic disease risk and is a recommended diet for prevention and management of diabetes. Adherence to the MD in the southeast United States where obesity and diabetes are highly prevalent is unknown. The purpose of the present study was to: 1) construct a survey instrument relevant to the general population integrating both MD related nutrition knowledge and adherence questions from previously validated instruments, and 2) assess MD related nutrition knowledge and adherence in a sample population in the southest United States...
December 23, 2016: Appetite
https://www.readbyqxmd.com/read/28017371/mixed-model-association-with-family-biased-case-control-ascertainment
#14
Tristan J Hayeck, Po-Ru Loh, Samuela Pollack, Alexander Gusev, Nick Patterson, Noah A Zaitlen, Alkes L Price
Mixed models have become the tool of choice for genetic association studies; however, standard mixed model methods may be poorly calibrated or underpowered under family sampling bias and/or case-control ascertainment. Previously, we introduced a liability threshold-based mixed model association statistic (LTMLM) to address case-control ascertainment in unrelated samples. Here, we consider family-biased case-control ascertainment, where case and control subjects are ascertained non-randomly with respect to family relatedness...
January 5, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28013375/alterations-in-pancreatic-%C3%AE-cell-function-and-trypanosoma-cruzi-infection-evidence-from-human-and-animal-studies
#15
REVIEW
Quinn Dufurrena, Farhad M Amjad, Philipp E Scherer, Louis M Weiss, Jyothi Nagajyothi, Jesse Roth, Herbert B Tanowitz, Regina Kuliawat
The parasite Trypanosoma cruzi causes a persistent infection, Chagas disease, affecting millions of persons in endemic areas of Latin America. As a result of immigration, this disease has now been diagnosed in non-endemic areas worldwide. Although, the heart and gastrointestinal tract are the most studied, the insulin-secreting β cell of the endocrine pancreas is also a target of infection. In this review, we summarize available clinical and laboratory evidence to determine whether T. cruzi-infection-mediated changes of β cell function is likely to contribute to the development of hyperglycemia and diabetes...
December 24, 2016: Parasitology Research
https://www.readbyqxmd.com/read/28009675/effects-of-foot-and-ankle-devices-on-balance-gait-and-falls-in-adults-with-sensory-perception-loss-a-systematic-review
#16
Joanne Paton, Anna L Hatton, Keith Rome, Bridie Kent
BACKGROUND: Foot and ankle devices are being developed as a method of preventing people with sensory perception loss sustaining a fall. Such devices are believed to work by reducing the likelihood of a fall by improving the balance and gait of the user. OBJECTIVES: The objective of the review was to evaluate the effectiveness of foot and ankle devices for the prevention of falls and the improvement of balance and gait in adults with sensory perception loss. INCLUSION CRITERIA TYPES OF PARTICIPANTS: Participants were community-dwelling adults with bilateral pathological sensory perception loss...
December 2016: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28007370/in-vivo-biodistribution-of-antihyperglycemic-biopolymer-based-nanoparticles-for-the-treatment-of-type-1-and-type-2-diabetes
#17
Marlene Lopes, Denise Aniceto, Margarida Abrantes, Susana Simões, Fábio Branco, Isabel Vitória, M Filomena Botelho, Raquel Seiça, Francisco Veiga, António Ribeiro
This study aimed to assess the biodistribution of antihyperglycemic insulin-loaded alginate/dextran sulfate-based nanoparticles dual coated with chitosan and technetium-99m-albumin ((99m)Tc-BSA) after oral administration. The oral administration of 50IU/kg insulin-loaded nanoparticles to type 1 diabetic rats showed prolonged antihyperglycemic effects up to 12h and relative pharmacological availability of 5.04% comparing to the subcutaneous administration. The oral antihyperglycemic effect was further compared between type 1 and type 2 diabetic models by the intraperitoneal glucose tolerance test, revealing that the effect lasted longer in the type 1 diabetic model...
December 19, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28002537/cerebral-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy-in-acromegalic-patient-with-severe-headache
#18
LuminiŢa Nicoleta Cima, Simona Vasilica Fica, Alice Ioana Albu, Ioana Maria Lambrescu, Ioana SmărăndiŢa Lăcău, Bogdan Ovidiu Popescu, Mihaela Gherghiceanu, Corin Virgil Badiu, Carmen Gabriela Barbu
A 68-year-old female patient was admitted in our clinic with severe frontal bilateral headache, dizziness, depression and cognitive decline in the context of a previously diagnosed acromegaly. She also had high blood pressure, dyslipidemia, secondary diabetes mellitus. Acromegaly was caused by a growth hormone (GH) secreting-pituitary macroadenoma, so a transsphenoidal surgery was performed. The postoperative magnetic resonance imaging (MRI) scan revealed a 20÷22÷25 mm pituitary mass remnant and medical therapy with somatostatin analogues (SSAs) was started...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27990686/validation-of-the-composite-autonomic-symptom-score-31-compass-31-for-the-assessment-of-symptoms-of-autonomic-neuropathy-in-people-with-diabetes
#19
C Greco, F Di Gennaro, C D'Amato, R Morganti, D Corradini, A Sun, S Longo, D Lauro, G Pierangeli, P Cortelli, V Spallone
AIM: To validate the Composite Autonomic Symptom Score (COMPASS) 31, in its Italian version, for the diagnosis of diabetic cardiovascular autonomic neuropathy in a clinic-based, single-centre study. METHODS: A total of 73 participants with diabetes (age 55±14 years) completed the COMPASS 31 questionnaire before undergoing cardiovascular autonomic neuropathy and diabetic polyneuropathy assessment according to cardiovascular reflex tests, neuropathic symptoms and signs, and vibration and thermal thresholds...
December 19, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27986673/diabetes-mellitus-and-latent-tuberculosis-infection-a-systemic-review-and-meta-analysis
#20
Meng-Rui Lee, Ya-Ping Huang, Yu-Ting Kuo, Chen-Hao Luo, Yun-Ju Shih, Chin-Chung Shu, Jann-Yuan Wang, Jen-Chung Ko, Chong-Jen Yu, Hsien-Ho Lin
BACKGROUND: Despite the well-documented association between diabetes and active tuberculosis, evidence on the association between diabetes on latent tuberculosis infection remains limited and inconsistent. METHODS: We included observational studies that: 1) applied either the tuberculin skin test or the interferon gamma release assay for diagnosis of latent tuberculosis infection; and 2) provided adjusted effect estimate for the association between diabetes and latent tuberculosis infection...
December 16, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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