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https://www.readbyqxmd.com/read/29928037/a-novel-computer-aided-diagnostic-approach-for-detecting-peripheral-arterial-disease-in-patients-with-diabetes
#1
Eva Elina Buschmann, Lulu Li, Michèle Brix, Andreas Zietzer, Philipp Hillmeister, Andreas Busjahn, Peter Bramlage, Ivo Buschmann
Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis, with diabetes being one of its most significant risk factors. Owing to medial arterial calcification (MAC), the ankle-brachial index (ABI) is not always a reliable tool for detecting PAD. Arterial Doppler flow parameters, such as systolic maximal acceleration (ACCmax) and relative pulse slope index (RPSI), may serve as effective surrogates to detect stenosis-induced flow alteration. In the present study, ACCmax and RPSI were prospectively evaluated in 166 patients (304 arteries) with clinical suspicion of PAD, including 76 patients with and 90 patients without diabetes...
2018: PloS One
https://www.readbyqxmd.com/read/29927635/comparative-effectiveness-of-18f-fdg-pet-ct-and-contrast-enhanced-ct-in-the-diagnosis-of-suspected-large-vessel-vasculitis
#2
Sriram Vaidyanathan, Arpita Chattopadhyay, Sarah L Mackie, Andrew Scarsbrook
OBJECTIVES: Large-vessel vasculitis (LVV) is a serious illness with potentially life-threatening consequences. 18 F-FDG PET-CT has emerged as a valuable diagnostic tool in suspected LVV, combining the strengths of functional and structural imaging. This study aimed to compare the accuracy of FDG PET-CT and contrast-enhanced CT (CECT) in the evaluation of patients with LVV. METHODS: A retrospective database review for LVV patients undergoing CECT and PET-CT between 2011 to 2016 yielded demographics, scan interval and vasculitis type...
June 21, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29923767/the-protective-role-of-trpc6-knockout-in-the-progression-of-diabetic-kidney-disease
#3
Denisha Spires, Daria V Ilatovskaya, Vladislav Levchenko, Paula E North, Aron M Geurts, Oleg Palygin, Alexander Staruschenko
Diabetic kidney disease (DKD) is a chronic kidney pathology that leads to end stage renal disease. Previous studies from our laboratory indicate that there is an association between the development of DKD and the TRPC6 channel. Trpc6 expression and activity was increased in the streptozotocin (STZ)-treated Dahl Salt-sensitive (SS) rat, an established model of type 1 diabetes. Here, using a Trpc6 knock-out created on the SS rat background (SSTRPC6-/- ), we test the hypothesis that the absence of Trpc6 will protect podocytes and kidney function during the development of DKD...
June 20, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29916732/accuracy-of-hba1c-as-monitored-by-external-quality-assessment-and-compared-with-patient-mean-values
#4
Gunnar Nordin
BACKGROUND: The accuracy and trueness of results from a laboratory test, such as the HbA1c test, should not be taken for granted but must be checked continuously. A tool for this is the participation in external quality assessment (EQA) for all laboratories performing the HbA1c-test. An additional possibility to detect changes in trueness is to monitor variations in patient cohort mean or median values that is not explained by changes in treatment or selection of patients. METHODS: Results reported to an EQA scheme for HbA1c during 20 years have been extracted from Equalis database...
June 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29915254/metabolic-remodelling-in-heart-failure
#5
REVIEW
Edoardo Bertero, Christoph Maack
The heart consumes large amounts of energy in the form of ATP that is continuously replenished by oxidative phosphorylation in mitochondria and, to a lesser extent, by glycolysis. To adapt the ATP supply efficiently to the constantly varying demand of cardiac myocytes, a complex network of enzymatic and signalling pathways controls the metabolic flux of substrates towards their oxidation in mitochondria. In patients with heart failure, derangements of substrate utilization and intermediate metabolism, an energetic deficit, and oxidative stress are thought to underlie contractile dysfunction and the progression of the disease...
June 18, 2018: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29906264/the-syntax-ii-score-predicts-mortality-at-4-years-in-patients-undergoing-percutaneous-coronary-intervention
#6
Sorin J Brener, Venkatesh Alapati, Doris Chan, Akanibo Da-Wariboko, Yousef Kaid, Yevgeniy Latyshev, Amr Moussa, Chockalingham A Narayanan, John P O'Laughlin, Amol Raizada, Gautam Verma, Terrence J Sacchi
BACKGROUND: Short-term outcome after percutaneous coronary intervention (PCI) has improved dramatically, but the association between clinical or angiographic characteristics and long-term outcome remains less well described. The SYNTAX (Synergy Between PCI With TAXUS and Cardiac Surgery) II score has been designed to overcome the limitations of the purely angiographic SYNTAX I score by including clinical parameters and comorbidities. It has not been tested extensively in "real-world" PCI patients, outside of randomized clinical studies...
June 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29905826/a-visual-analytics-approach-for-pattern-recognition-in-patient-generated-data
#7
Daniel J Feller, Marissa Burgermaster, Matthew E Levine, Arlene Smaldone, Patricia G Davidson, David J Albers, Lena Mamykina
Objective: To develop and test a visual analytics tool to help clinicians identify systematic and clinically meaningful patterns in patient-generated data (PGD) while decreasing perceived information overload. Methods: Participatory design was used to develop Glucolyzer, an interactive tool featuring hierarchical clustering and a heatmap visualization to help registered dietitians (RDs) identify associative patterns between blood glucose levels and per-meal macronutrient composition for individuals with type 2 diabetes (T2DM)...
June 13, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29899998/a-longitudinal-study-examining-the-change-in-functional-independence-over-time-in-elderly-individuals-with-a-functioning-kidney-transplant
#8
Kevin Yau, Janine F Farragher, S Joseph Kim, Olusegun Famure, Sarbjit V Jassal
Background: Functional disability is defined as the need for assistance with self-care tasks. Objective: To document changes in functional status over time among older prevalent renal transplant recipients. Design: Single center, prospective, follow-up study. Setting: Single center, tertiary care transplant center. Patients: Patients, with a functioning kidney transplant, aged 65 years or older who underwent assessment of functional status approximately 12 months previously...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29896157/continuous-blood-glucose-monitoring-reveals-enormous-circadian-variations-in-pregnant-diabetic-rats
#9
Michaela Golic, Kristin Kräker, Caroline Fischer, Natalia Alenina, Nadine Haase, Florian Herse, Till Schütte, Wolfgang Henrich, Dominik N Müller, Andreas Busjahn, Michael Bader, Ralf Dechend
Aim: Diabetes in pregnancy is a major burden with acute and long-term consequences. Its treatment requires adequate diagnosis and monitoring of therapy. Many experimental research on diabetes during pregnancy has been performed in rats. Recently, continuous blood glucose monitoring of non-pregnant diabetic rats revealed an increased circadian variability of blood glucose that made a single blood glucose measurement per day inappropriate to reflect glycemic status. Continuous blood glucose measurement has never been performed in pregnant rats...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29888221/ligand-screening-systems-for-human-glucose-transporters-as-tools-in-drug-discovery
#10
REVIEW
Sina Schmidl, Cristina V Iancu, Jun-Yong Choe, Mislav Oreb
Hexoses are the major source of energy and carbon skeletons for biosynthetic processes in all kingdoms of life. Their cellular uptake is mediated by specialized transporters, including glucose transporters (GLUT, SLC2 gene family). Malfunction or altered expression pattern of GLUTs in humans is associated with several widespread diseases including cancer, diabetes and severe metabolic disorders. Their high relevance in the medical area makes these transporters valuable drug targets and potential biomarkers...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29883970/the-effects-of-vitamin-d-supplementation-on-biomarkers-of-inflammation-and-oxidative-stress-in-diabetic-patients-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
Mohammad Ali Mansournia, Vahidreza Ostadmohammadi, Amin Doosti-Irani, Majid Ghayour-Mobarhan, Gordon Ferns, Hossein Akbari, Amir Ghaderi, Hamid Reza Talari, Zatollah Asemi
In this systematic review and meta-analysis of randomized controlled trials (RCTs), the effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress in diabetic patients are summarized. The following databases were searched up to December 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The quality of the relevant extracted data was assessed according to the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as mean difference with 95% Confidence Intervals (95% CI)...
June 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29883192/lessons-learned-from-implementing-a-new-testing-educational-tool-for-patients-using-an-insulin-pump
#12
Katerina Stechova, Miroslav Vanis, Martina Tuhackova, Krzysztof Urbaniec, Milan Kvapil
BACKGROUND: To improve insulin pump therapy results, a special test for patients was devised. The model successfully used to achieve a license to operate different machines was followed. METHODS: The test (a practice and a full run, with a time limit) contained 42 questions, each with four optional choices, and could be answered online. Patients could familiarize themselves with the whole question pool first. Patients could repeat a full run attempt if they failed and were offered focused remedial education...
June 8, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29882311/quality-assessment-of-diabetic-foot-ulcer-clinical-practice-guidelines
#13
Atefeh Ghanbari, Pardis Rahmatpour, Fateme Jafaraghaee, Ehsan Kazemnejad, Malahat Khalili
OBJECTIVE: Nurses play an effective role in diabetic foot care and they should know the best evidence. In this way, implementations according evidence-based clinical practice guidelines have positive effects on nurses' practice and patient outcomes. The objective of this study was quality assessment of diabetic foot ulcer clinical practice guidelines. METHODS: Evidence about nursing care in diabetic foot ulcer in last 5 years was searched and categorized based on nursing diagnosis (ND) and evidence levels and was finally designed as a guideline...
June 7, 2018: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/29879054/association-between-muscle-strength-and-type-2-diabetes-mellitus-in-adults-in-korea-data-from-the-korea-national-health-and-nutrition-examination-survey-knhanes-vi
#14
Mee-Ri Lee, Sung Min Jung, Hyuk Bang, Hwa Sung Kim, Yong Bae Kim
Diabetes mellitus (DM) is a significant chronic disease, and health burden from DM is increasing. Recently, studies on the relationship between handgrip strength, which is a measuring tool for muscle strength, and type 2 DM were published. However, the results have been conflicting. In addition, few studies that used data from adults in Korea have been conducted. Thus, this study aimed to identify the association between handgrip strength as well as type 2 DM and insulin resistance in adults using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2014 to 2015...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29872446/testing-calibration-of-cox-survival-models-at-extremes-of-event-risk
#15
David M Soave, Lisa J Strug
Risk prediction models can translate genetic association findings for clinical decision-making. Most models are evaluated on their ability to discriminate, and the calibration of risk-prediction models is largely overlooked in applications. Models that demonstrate good discrimination in training datasets, if not properly calibrated to produce unbiased estimates of risk, can perform poorly in new patient populations. Poorly calibrated models arise due to missing covariates, such as genetic interactions that may be unknown or not measured...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29871909/probing-insulin-sensitivity-in-diabetic-kidney-disease-is-there-a-stronger-role-for-functional-imaging
#16
REVIEW
Michael L Granda, Pooja Amarapurkar, Alessia Fornoni
Clinical and experimental evidence support a cause-effect relationship between altered insulin signaling and development of kidney disease of metabolic and non-metabolic origin. However, the current criteria to measure and/or estimate the insulin resistance (IR) are available as research tool but are very difficult to implement in the clinical practice. Therefore, a better understanding of the key players contributing to IR may lead to the development of new non-invasive tools to assess organ-specific insulin sensitivity (IS)...
June 14, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29867778/genetic-testing-of-maturity-onset-diabetes-of-the-young-current-status-and-future-perspectives
#17
REVIEW
Parveena Firdous, Kamran Nissar, Sajad Ali, Bashir Ahmad Ganai, Uzma Shabir, Toyeeba Hassan, Shariq Rashid Masoodi
Diabetes is a global epidemic problem growing exponentially in Asian countries posing a serious threat. Among diabetes, maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic disorders that occurs due to β cell dysfunction. Genetic defects in the pancreatic β-cells result in the decrease of insulin production required for glucose utilization thereby lead to early-onset diabetes (often <25 years). It is generally considered as non-insulin dependent form of diabetes and comprises of 1-5% of total diabetes...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29866643/assessing-statewide-all-cause-future-one-year-mortality-prospective-study-with-implications-for-quality-of-life-resource-utilization-and-medical-futility
#18
Yanting Guo, Gang Zheng, Tianyun Fu, Shiying Hao, Chengyin Ye, Le Zheng, Modi Liu, Minjie Xia, Bo Jin, Chunqing Zhu, Oliver Wang, Qian Wu, Devore S Culver, Shaun T Alfreds, Frank Stearns, Laura Kanov, Ajay Bhatia, Karl G Sylvester, Eric Widen, Doff B McElhinney, Xuefeng Bruce Ling
BACKGROUND: For many elderly patients, a disproportionate amount of health care resources and expenditures is spent during the last year of life, despite the discomfort and reduced quality of life associated with many aggressive medical approaches. However, few prognostic tools have focused on predicting all-cause 1-year mortality among elderly patients at a statewide level, an issue that has implications for improving quality of life while distributing scarce resources fairly. OBJECTIVE: Using data from a statewide elderly population (aged ≥65 years), we sought to prospectively validate an algorithm to identify patients at risk for dying in the next year for the purpose of minimizing decision uncertainty, improving quality of life, and reducing futile treatment...
June 4, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29860640/multilevel-and-community-level-interventions-with-native-americans-challenges-and-opportunities
#19
Valarie Blue Bird Jernigan, Elizabeth J D'Amico, Bonnie Duran, Dedra Buchwald
Multilevel and community-level interventions that target the social determinants of health and ultimately health disparities are seldom conducted in Native American communities. To contextualize the importance of multilevel and community-level interventions, major contributors to and causes of health disparities in Native communities are highlighted. Among the many documented socioeconomic factors influencing health are poverty, low educational attainment, and lack of insurance. Well-recognized health disparities include obesity, diabetes, and hypertension...
June 2, 2018: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/29859538/weight-bearing-versus-non-weight-bearing-ankle-dorsiflexion-measurement-in-people-with-diabetes-a-cross-sectional-study
#20
A Searle, M J Spink, V H Chuter
BACKGROUND: Accurate measurement of ankle dorsiflexion is important in both research and clinical practice as restricted motion has been associated with many foot pathologies and increased risk of ulcer in people with diabetes. This study aimed to determine the level of association between non-weight bearing versus weight bearing ankle dorsiflexion in adults with and without diabetes, and to evaluate the reliability of the measurement tools. METHODS: One hundred and thirty-six adults with diabetes and 30 adults without diabetes underwent ankle dorsiflexion measurement non-weight bearing, using a modified Lidcombe template, and weight bearing, using a Lunge test...
June 2, 2018: BMC Musculoskeletal Disorders
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