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https://www.readbyqxmd.com/read/27886939/development-and-implementation-of-models-of-care-for-musculoskeletal-conditions-in-middle-income-and-low-income-asian-countries
#1
REVIEW
Keith K Lim, Madelynn Chan, Sandra Navarra, Syed Atiqul Haq, Chak Sing Lau
This chapter discusses the challenges faced in the development and implementation of musculoskeletal (MSK) Models of Care (MoCs) in middle-income and low-income countries in Asia and outlines the components of an effective MoC for MSK conditions. Case studies of four such countries (The Philippines, Malaysia, Bangladesh and Myanmar) are presented, and their unique implementation issues are discussed. The success experienced in one high-income country (Singapore) is also described as a comparison. The Community Oriented Program for Control of Rheumatic Diseases (COPCORD) project and the role of Asia Pacific League of Associations for Rheumatology (APLAR), a professional body supporting MoC initiatives in this region, are also discussed...
June 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27875625/clinical-and-genetic-determinants-of-ovarian-metastases-from-colorectal-cancer
#2
Karuna Ganesh, Ronak H Shah, Efsevia Vakiani, Garrett M Nash, Hugh P Skottowe, Rona Yaeger, Andrea Cercek, Anne Lincoln, Christina Tran, Neil H Segal, Diane L Reidy, Anna Varghese, Andrew S Epstein, Yukio Sonoda, Dennis Chi, Jose Guillem, Larissa Temple, Philip Paty, Jaclyn Hechtman, Jinru Shia, Martin Weiser, Julio Garcia Aguilar, Nancy Kemeny, Michael F Berger, Leonard Saltz, Zsofia K Stadler
BACKGROUND: Ovarian metastases from colorectal cancer (OM-CRC) often are unresponsive to chemotherapy and are associated with poor survival. To the authors' knowledge, the clinicopathologic and genomic predictors of OM-CRC are poorly characterized and optimal clinical management remains unclear. METHODS: Women with a histopathological diagnosis of OM-CRC who were treated at Memorial Sloan Kettering Cancer Center from 1999 to 2015 were identified. Next-generation somatic mutation profiling (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets [MSK-IMPACT]) was performed on 38 OM-CRC cases, including 21 matched tumor pairs/trios...
November 22, 2016: Cancer
https://www.readbyqxmd.com/read/27672904/poster-137-delayed-diagnosis-of-popliteal-artery-entrapment-mistaken-for-exertional-compartment-syndrome-novel-use-of-msk-us-to-improve-diagnostic-sensitivity-a-case-report
#3
Ilya Igolnikov, Matthew J Santiago, Kathryn T Gollotto
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27612911/tuberculosis-is-a-mimicker-of-jia-a-rare-case-report
#4
M A Shahin, M I Sultan, M J Alam, A Saeed, A K Azad, M R Choudhury
Cystic tuberculosis of the bone is a rare form of tuberculosis (TB). The condition presents like Juvenile idiopathic arthritis (JIA) of children. In children, the lesions symmetrically involve the peripheral skeleton, which are less sclerotic than adults. A case report is presented here where the patient presented with i) the extensive involvement of bones with cystic lesion, ii) Hand & feet involvement with multiple bony exostosis iii) Synovial swelling of multiple joints and 4) fever for 6 months. Swelling of the joints was disproportionately greater than pain...
July 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27605463/review-of-the-effectiveness-of-a-consultant-physiotherapy-led-musculoskeletal-interface-team-a-welsh-experience
#5
Elizabeth Candy, Sam Haworth-Booth, Mark Knight-Davis
OBJECTIVE: The present service evaluation aimed to assess patients' experience of the musculoskeletal interface (MSKI) team, evaluate the outcomes of referrals to secondary care and determine if patients returned to secondary musculoskeletal (MSK) care following discharge from the MSKI team. METHODS: Excel spreadsheets were designed for data capture. The survey was undertaken in June 2012. Patients were invited to complete and return the questionnaire. Data were collated and reported...
September 2016: Musculoskeletal Care
https://www.readbyqxmd.com/read/27437719/musculoskeletal-pain-in-children-and-adolescents
#6
Steve J Kamper, Nicholas Henschke, Lise Hestbaek, Kate M Dunn, Christopher M Williams
INTRODUCTION: Musculoskeletal (MSK) pain in children and adolescents is responsible for substantial personal impacts and societal costs, but it has not been intensively or systematically researched. This means our understanding of these conditions is limited, and healthcare professionals have little empirical evidence to underpin their clinical practice. In this article we summarise the state of the evidence concerning MSK pain in children and adolescents, and offer suggestions for future research...
February 16, 2016: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/27282352/mammary-analog-secretory-carcinoma-of-the-thyroid-gland-a-primary-thyroid-adenocarcinoma-harboring-etv6-ntrk3-fusion
#7
Snjezana Dogan, Lu Wang, Ryan N Ptashkin, Robert R Dawson, Jatin P Shah, Eric J Sherman, R Michael Tuttle, James A Fagin, David S Klimstra, Nora Katabi, Ronald A Ghossein
ETV6-NTRK3 fusion was identified in several cancers including the recently described mammary analog secretory carcinoma (MASC) of the salivary glands and a minority of papillary thyroid carcinomas. We describe three cases of primary MASC of the thyroid gland and provide a detailed clinical and pathological characterization of the tumor morphology, immunoprofile, and genetic background. Immunohistochemistry for PAX8, TTF-1, thyroglobulin, mammaglobin, GCDFP-15, S-100 protein, and p63 was used to define the tumor immunophenotype...
September 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27248473/recurrent-truncating-sox9-mutations-are-associated-with-sox9-overexpression-kras-mutation-and-tp53-wild-type-status-in-colorectal-carcinoma
#8
Breanna M Javier, Rona Yaeger, Lu Wang, Francisco Sanchez-Vega, Ahmet Zehir, Sumit Middha, Justyna Sadowska, Efsevia Vakiani, Jinru Shia, David Klimstra, Marc Ladanyi, Christine A Iacobuzio-Donahue, Jaclyn F Hechtman
PURPOSE: The extent to which the developmental transcription factor SOX9 functions as an oncogene or tumor suppressor in colorectal carcinoma (CRC) is debatable. We aimed to clarify the effect of SOX9 mutations on SOX9 protein expression and their association with known molecular subtypes and clinical characteristics in advanced CRC. EXPERIMENTAL DESIGN: Next generation sequencing data (MSK-IMPACT) from CRC patients was used to interrogate SOX9, KRAS, NRAS, BRAF, TP53, APC, and PIK3CA...
May 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27219305/rheumatic-diseases-in-chihuahua-m%C3%A3-xico-a-copcord-survey
#9
Danyella Del Río Nájera, Susana Aideé González-Chávez, Celia María Quiñonez-Flores, Ingris Peláez-Ballestas, Norma Hernández-Nájera, César F Pacheco-Tena
BACKGROUND: Rheumatic diseases (RDs) represent a global problem for health care systems and patients. Community Oriented Program for Control of Rheumatic Diseases (COPCORD) is a low-cost screening tool for detecting musculoskeletal (MSK) pain and RDs. OBJECTIVE: The aim of this study was to examine the pattern of MSK pain and RDs in clinic population in Chihuahua City, Mexico. METHODS: A cross-sectional study was conducted in 7 primary health clinics using the COPCORD methodology in subjects older than 18 years...
June 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27139150/interobserver-variability-in-the-diagnosis-of-uterine-high-grade-endometrioid-carcinoma
#10
Sumi Thomas, Yaser Hussein, Sudeshna Bandyopadhyay, Michele Cote, Oudai Hassan, Eman Abdulfatah, Baraa Alosh, Hui Guan, Robert A Soslow, Rouba Ali-Fehmi
CONTEXT: -Low interobserver diagnostic agreement exists among high-grade endometrial carcinomas. OBJECTIVE: -To evaluate diagnostic variability in International Federation of Gynecology and Obstetrics (FIGO) grade 3 endometrioid adenocarcinoma (G3EC) in 2 different sign-out practices. DESIGN: -Sixty-six G3EC cases were identified from pathology archives of Wayne State University (WSU, Detroit, Michigan) (general surgical pathology sign-out) and 65 from Memorial Sloan Kettering Cancer Center (MSK, New York, New York) (gynecologic pathology focused sign-out)...
August 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27058462/second-opinion-subspecialty-consultations-in-musculoskeletal-radiology
#11
Majid Chalian, Filippo Del Grande, Rashmi S Thakkar, Sahar F Jalali, Avneesh Chhabra, John A Carrino
OBJECTIVE: The purpose of this article is to evaluate the significance of subspecialty second-opinion consultations for CT and MRI examinations in musculoskeletal (MSK) radiology. MATERIALS AND METHODS: All 3165 MSK CT and MRI examinations referred to one academic institution for second-opinion consultation during a 24-month period were reviewed by three MSK-trained radiologists. Outside and inside reports were compared by two independent MSK radiology fellows using a previously published 5-point scale...
June 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27054846/run-off-computed-tomography-angiography-cta-for-discriminating-the-underlying-causes-of-intermittent-claudication
#12
Alexandra Preuß, Lars-Arne Schaafs, Thomas Werncke, Ingo G Steffen, Bernd Hamm, Thomas Elgeti
AIM: To evaluate run-off computed tomography angiography (CTA) of abdominal aorta and lower extremities for detecting musculoskeletal pathologies and clinically relevant extravascular incidental findings in patients with intermittent claudication (IC) and suspected peripheral arterial disease (PAD). Does run-off CTA allow image-based therapeutic decision making by discriminating the causes of intermittent claudication in patients with suspected peripheral arterial disease PAD? MATERIAL AND METHODS: Retrospective re-evaluation of CTAs performed in patients with acute or chronic intermittent claudication (i...
2016: PloS One
https://www.readbyqxmd.com/read/27022117/reliable-detection-of-mismatch-repair-deficiency-in-colorectal-cancers-using-mutational-load-in-next-generation-sequencing-panels
#13
Zsofia K Stadler, Francesca Battaglin, Sumit Middha, Jaclyn F Hechtman, Christina Tran, Andrea Cercek, Rona Yaeger, Neil H Segal, Anna M Varghese, Diane L Reidy-Lagunes, Nancy E Kemeny, Erin E Salo-Mullen, Asad Ashraf, Martin R Weiser, Julio Garcia-Aguilar, Mark E Robson, Kenneth Offit, Maria E Arcila, Michael F Berger, Jinru Shia, David B Solit, Leonard B Saltz
PURPOSE: Tumor screening for Lynch syndrome is recommended in all or most patients with colorectal cancer (CRC). In metastatic CRC, sequencing of RAS/BRAF is necessary to guide clinical management. We hypothesized that a next-generation sequencing (NGS) panel that identifies RAS/BRAF and other actionable mutations could also reliably identify tumors with DNA mismatch repair protein deficiency (MMR-D) on the basis of increased mutational load. METHODS: We identified all CRCs that underwent genomic mutation profiling with a custom NGS assay (MSK-IMPACT) between March 2014 and July 2015...
June 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/26956444/prevalence-of-rheumatic-diseases-in-raramuri-people-in-chihuahua-mexico-a-community-based-study
#14
Danyella Del Río Nájera, Natalia Santana, Ingris Peláez-Ballestas, Susana A González-Chávez, Celia M Quiñonez-Flores, César Pacheco-Tena
This study aimed to determine the prevalence of musculoskeletal (MSK) pain and rheumatic diseases in the Raramuri population (also known as Tarahumaras) who are an indigenous group in the northern state of Chihuahua in Mexico. We used the Community-Oriented Program for Control of Rheumatic Diseases (COPCORD) methodology. An analytical cross-sectional study was conducted including indigenous Raramuri aged ≥18 years from communities settled in Chihuahua City. Subjects with positive MSK pain were evaluated by primary care physicians and rheumatologists...
July 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/26908521/any-qualified-provider-a-qualitative-case-study-of-one-community-nhs-trust-s-response
#15
Jackie Walumbe, Deborah Swinglehurst, Sara Shaw
OBJECTIVE: To examine how those managing and providing community-based musculoskeletal (MSK) services have experienced recent policy allowing patients to choose any provider that meets certain quality standards from the National Health Service (NHS), private or voluntary sector. DESIGN: Intrinsic case study combining qualitative analysis of interviews and field notes. SETTING: An NHS Community Trust (the main providers of community health services in the NHS) in England, 2013-2014...
2016: BMJ Open
https://www.readbyqxmd.com/read/26886462/musculoskeletal-pain-in-children-and-adolescents
#16
Steve J Kamper, Nicholas Henschke, Lise Hestbaek, Kate M Dunn, Christopher M Williams
Introduction Musculoskeletal (MSK) pain in children and adolescents is responsible for substantial personal impacts and societal costs, but it has not been intensively or systematically researched. This means our understanding of these conditions is limited, and healthcare professionals have little empirical evidence to underpin their clinical practice. In this article we summarise the state of the evidence concerning MSK pain in children and adolescents, and offer suggestions for future research. Results Rates of self-reported MSK pain in adolescents are similar to those in adult populations and they are typically higher in teenage girls than boys...
February 16, 2016: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/26689797/epidemiology-of-rheumatic-diseases-in-mixtec-and-chontal-indigenous-communities-in-mexico-a-cross-sectional-community-based-study
#17
Flor Julián-Santiago, Conrado García-García, Imelda García-Olivera, María Victoria Goycochea-Robles, Ingris Pelaez-Ballestas
This study aimed to estimate the prevalence of musculoskeletal (MSK) disorders and rheumatic diseases in the Chontal and Mixtec indigenous communities in the state of Oaxaca, Mexico, using the Community-Oriented Program for the Control of Rheumatic Diseases (COPCORD) methodology. After cross-culturally validating the COPCORD questionnaire for these communities, we conducted a cross-sectional, analytical, community-based census study using a house-to-house method. Positive cases of MSK disorders were assessed by primary care physicians and rheumatologists...
July 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/26660078/identification-of-targetable-kinase-alterations-in-patients-with-colorectal-carcinoma-that-are-preferentially-associated-with-wild-type-ras-raf
#18
Jaclyn F Hechtman, Ahmet Zehir, Rona Yaeger, Lu Wang, Sumit Middha, Tao Zheng, David M Hyman, David Solit, Maria E Arcila, Laetitia Borsu, Jinru Shia, Efsevia Vakiani, Leonard Saltz, Marc Ladanyi
UNLABELLED: Targeted therapy for metastatic colorectal carcinoma consists of anti-EGFR therapy for patients with RAS/RAF wild-type tumors. However, the response rate remains low, suggesting the presence of alternative drivers possibly also representing potential therapeutic targets. We investigated receptor tyrosine kinase (RTK) alterations and MAP2K1 (MEK1) mutations in a large cohort of colorectal carcinoma patients studied by Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets and The Cancer Genome Atlas, focusing on amplifications, fusions, and hotspot mutations in RTK genes and MAP2K1...
March 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/26657888/national-audits-of-hip-fractures-are-yearly-audits-required
#19
Kim B Ferguson, Mansur Halai, Alison Winter, Tom Elswood, Rik Smith, James D Hutchison, Graeme Holt
INTRODUCTION: Hip fractures are a significant cause of morbidity and mortality to the increasing elderly population. The Scottish Hip Fracture Audit started in 1993 with national audits from 2002. It was a national prospective audit reporting on clinical standards in hip fracture care and produced an annual report. Due to national funding changes the continual audit was discontinued in 2008. In 2013, the MSK Audit Group published a "snapshot" into a 4 month period of hip fracture care in Scotland...
February 2016: Injury
https://www.readbyqxmd.com/read/26626387/estimation-of-absolute-free-energies-of-hydration-using-continuum-methods-%C3%A2-accuracy-of-partial-charge-models-and-optimization-of-nonpolar-contributions
#20
Robert C Rizzo, Tiba Aynechi, David A Case, Irwin D Kuntz
Absolute free energies of hydration (ΔGhyd) for more than 500 neutral and charged compounds have been computed, using Poisson-Boltzmann (PB) and Generalized Born (GB) continuum methods plus a solvent-accessible surface area (SA) term, to evaluate the accuracy of eight simple point-charge models used in molecular modeling. The goal is to develop improved procedures and protocols for protein-ligand binding calculations and virtual screening (docking). The best overall PBSA and GBSA results, in comparison with experimental ΔGhyd values for small molecules, were obtained using MSK, RESP, or ChelpG charges obtained from ab initio calculations using 6-31G* wave functions...
January 2006: Journal of Chemical Theory and Computation
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