keyword
MENU ▼
Read by QxMD icon Read
search

Pain mechanisms

keyword
https://www.readbyqxmd.com/read/29691410/control-of-mechanical-pain-hypersensitivity-in-mice-through-ligand-targeted-photoablation-of-trkb-positive-sensory-neurons
#1
Rahul Dhandapani, Cynthia Mary Arokiaraj, Francisco J Taberner, Paola Pacifico, Sruthi Raja, Linda Nocchi, Carla Portulano, Federica Franciosa, Mariano Maffei, Ahmad Fawzi Hussain, Fernanda de Castro Reis, Luc Reymond, Emerald Perlas, Simone Garcovich, Stefan Barth, Kai Johnsson, Stefan G Lechner, Paul A Heppenstall
Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve injury in mice. Mice in which TrkB-Cre-expressing neurons are ablated are less sensitive to the lightest touch under basal conditions, and fail to develop mechanical allodynia in a model of neuropathic pain. Moreover, selective optogenetic activation of these neurons after nerve injury evokes marked nociceptive behavior...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29691246/effectiveness-of-implementing-a-best-practice-primary-healthcare-model-for-low-back-pain-betterback-compared-with-current-routine-care-in-the-swedish-context-an-internal-pilot-study-informed-protocol-for-an-effectiveness-implementation-hybrid-type-2-trial
#2
Allan Abbott, Karin Schröder, Paul Enthoven, Per Nilsen, Birgitta Öberg
INTRODUCTION: Low back pain (LBP) is a major health problem commonly requiring healthcare. In Sweden, there is a call from healthcare practitioners (HCPs) for the development, implementation and evaluation of a best practice primary healthcare model for LBP. AIMS: (1) To improve and understand the mechanisms underlying changes in HCP confidence, attitudes and beliefs for providing best practice coherent primary healthcare for patients with LBP; (2) to improve and understand the mechanisms underlying illness beliefs, self-care enablement, pain, disability and quality of life in patients with LBP; and (3) to evaluate a multifaceted and sustained implementation strategy and the cost-effectiveness of the BetterBack☺ model of care (MOC) for LBP from the perspective of the Swedish primary healthcare context...
April 24, 2018: BMJ Open
https://www.readbyqxmd.com/read/29690857/the-expression-of-transmembrane-protein-100-is-regulated-by-alterations-in-calcium-signaling-rather-than-endoplasmic-reticulum-stress
#3
Ayane Kuboyama, Takashi Sasaki, Makoto Shimizu, Jun Inoue, Ryuichiro Sato
Transmembrane protein 100 (TMEM100) comprises 134 amino acid residues and is highly conserved among vertebrates. Tmem100 has been recently reported as a key factor in angiogenesis, pain transmission, and tumor suppression. Although the importance of TMEM100 function is well supported, few studies have elucidated its expression mechanism. In the current study, we found that activating transcription factor 6α, a transcription factor activated by endoplasmic reticulum (ER) stress, enhanced Tmem100 promoter activity...
April 25, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29690828/evidence-for-increased-mri-signal-intensity-and-morphological-changes-in-the-brachial-plexus-and-median-nerves-of-patients-with-chronic-arm-and-neck-pain-following-whiplash-injury
#4
Jane Greening, Kamakshi Anantharaman, Rupert Young, Andrew Dilley
Study Design Cross-sectional study. Background Whiplash following a motor vehicle accident can result in chronic neck and arm pain. Patients frequently present with cutaneous hypersensitivities and hypoesthesia but without obvious clinical sign of nerve injury. T2-weighted magnetic resonance imaging (MRI) has previously been used to identify nerve pathology. Objectives To determine whether there are signs of peripheral nerve pathology on MRI in patients with chronic arm and neck pain following whiplash injury...
April 24, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29690806/a-case-of-ankylosing-spondylitis-with-concurrent-takayasu-arteritis
#5
Masakazu Matsushita, Shigeto Kobayashi, Kurisu Tada, Eri Hayashi, Ken Yamaji, Atsushi Amano, Naoto Tamura
We herein report a case involving a 56-year-old man who had experienced neck and lower back pain since the age of 23 years. Ankylosing spondylitis (AS) was diagnosed at 41 years of age, and treatment with sulfasalazine was initiated. At 44 years of age, the patient developed respiratory distress on exertion and chest pain. Aortic regurgitation (AR) was diagnosed via echocardiography, and the patient presented to our hospital for close examination and treatment. Coronary computed tomography angiography revealed no lesions in the coronary artery; however, magnetic resonance angiography revealed stenotic lesions in the left common carotid artery and left subclavian artery...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29690724/-the-effect-of-berberine-on-ameliorating-chronic-inflammatory-pain-and-depression
#6
F Xu, J Yang, B Meng, J W Zheng, Q Liao, J P Chen, X W Chen
Objective: To explore the effect of berberine on chronic inflammatory pain and the comorbid depression and the associated mechanisms. Methods: Forty healthy male ICR mice (2 months, 25-30 g) were used in the present study. The chronic inflammatory pain was induced by intraplantar injection of complete freund's adjuvant (CFA) to the hind paws. All animals were divided into 4 groups ( n =10 for each group) according to random number table: the saline group (group A), the chronic pain group (group B), the saline+ berberine group (group C) and the chronic pain+ berberine group (group D)...
April 10, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29690597/liu-jun-zi-tang-a-potential-multi-herbal-complementary-therapy-for-chemotherapy-induced-neurotoxicity
#7
Chun-Tang Chiou, Kaw-Chen Wang, Ying-Chen Yang, Chuen-Lin Huang, Sien-Hung Yang, Yao-Haur Kuo, Nai-Kuei Huang
Liu Jun Zi Tang (LJZT) has been used to treat functional dyspepsia and depression, suggesting its effects on gastrointestinal and neurological functions. LJZT is currently used as a complementary therapy to attenuate cisplatin-induced side effects, such as dyspepsia. However, its effect on chemotherapy-induced neuropathic pain or neurotoxicity has rarely been studied. Thus, we explored potential mechanisms underlying LJZT protection against cisplatin-induced neurotoxicity. We observed that LJZT attenuated cisplatin-induced thermal hyperalgesia in mice and apoptosis in human neuroblastoma SH-SY5Y cells...
April 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29690562/ethanol-extract-of-evodia-rutaecarpa-attenuates-cell-growth-through-caspase-dependent-apoptosis-in-benign-prostatic-hyperplasia-1-cells
#8
Eunsook Park, Mee-Young Lee, Chang-Seob Seo, Ji-Hye Jang, Yong-Ung Kim, Hyeun-Kyoo Shin
The dried fruits of Evodia rutaecarpa Bentham have been used widely as a herbal medicine for the treatment of inflammatory disorders and abdominal pain. Benign prostatic hyperplasia (BPH) is a nonmalignant disease characterized by overgrowth of prostates. Despite the pharmacological efficacy of the fruits of E. rutaecarpa against various diseases, their effects against BPH have not been reported. Here, we investigated the inhibitory activity of a 70% ethanol extract of E. rutaecarpa (EEER) against BPH, and its underlying mechanisms regarding cell growth of BPH using BPH-1 cells...
April 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29690530/therapeutic-approaches-of-botulinum-toxin-in-gynecology
#9
REVIEW
Marius Alexandru Moga, Oana Gabriela Dimienescu, Andreea Bălan, Ioan Scârneciu, Barna Barabaș, Liana Pleș
Botulinum toxins (BoNTs) are produced by several anaerobic species of the genus Clostridium and, although they were originally considered lethal toxins, today they find their usefulness in the treatment of a wide range of pathologies in various medical specialties. Botulinum neurotoxin has been identified in seven different isoforms (BoNT-A, BoNT-B, BoNT-C, BoNT-D, BoNT-E, BoNT-F, and BoNT-G). Neurotoxigenic Clostridia can produce more than 40 different BoNT subtypes and, recently, a new BoNT serotype (BoNT-X) has been reported in some studies...
April 21, 2018: Toxins
https://www.readbyqxmd.com/read/29689688/swimming-exercise-induced-reversed-expression-of-mir-96-and-its-target-gene-nav1-3-in-diabetic-peripheral-neuropathy-in-rats
#10
Amir Mahmoudi Aghdam, Parviz Shahabi, Elham Karimi-Sales, Rafigheh Ghiasi, Saeed Sadigh-Eteghad, Javad Mahmoudi, Mohammad Reza Alipour
Diabetes is a common metabolic disease which leads to diabetic peripheral neuropathy. Recently, the role of microRNA-96 (miR-96) in alleviating neuropathic pain by inhibiting the expression of NaV1.3, an isoform of voltage-gated sodium channels, has been shown. Peripheral nerve injuries result in NaV1.3 elevation. Exercise has beneficial role in diabetes management and peripheral neuropathy. However, the effects of exercise on miR-96 and its target gene NaV1.3 in diabetic rats are unknown. Therefore, the present study investigated the effects of exercise training on the expression of miR-96 and NaV1...
April 25, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29687967/vertebral-compression-fractures-associated-with-yoga-a-case-series
#11
Jad G Sfeir, Matthew T Drake, Vikram J Sonawane, Mehrsheed Sinaki
BACKGROUND: The importance of exercise in skeletal health is increasingly recognized by both patients and providers. However, the safety of prescribed or recreational exercise in at-risk populations remains under-reported and under-publicized. Yoga has gained widespread popularity due to its physical and psychological benefits. When practiced in a population at increased fracture risk, however, some yoga poses may increase fracture risk, particularly at the spine, rather than increasing BMD as noted in recent popular press reports...
April 24, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29687858/mir-30a-relieves-migraine-by-degrading-calca
#12
Y Zhai, Y-Y Zhu
OBJECTIVE: To investigate both the relationship and underlying mechanism between miR-30a and migraine. PATIENTS AND METHODS: Peripheral blood samples were collected from migraine patients and healthy people to extract RNA for quantitative Real-time PCR (qRT-PCR). The relationship between mRNA expressions and patient data was analyzed by t-test. Target genes of miR-30a were predicted by the TargetScan. The binding of miR-30a to the target gene was verified by dual fluorescein reporter assay...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29687782/status-report-of-analgesic-prescriptions-by-general-practitioners-in-elderly-people-aged-75-and-over-upon-admission-in-geriatric-medicine
#13
Hélène Chevé, Anne-Claire Marinthe, Véronique Lelong-Boulouard, Pascale Lescure, Cyril Guillaumé
The main objective of this study is to describe the current therapeutic strategy for pain in elderly patients, by general practitioners. In this prospective study, 149 patients aged 75 years and over, hospitalized in geriatric medicine at the University Hospital of Caen, were recruited between June and September 2015. All analgesic data was recorded from the patients' prescriptions and medical files. 66% of the patients had at least one analgesic. More than 96% of patients who took analgesics were treated with a step 1 analgesic (mainly paracetamol), and approximately 30% received a step 2 analgesic (69% tramadol)...
April 24, 2018: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/29687346/long-term-cognitive-outcomes-after-sepsis-a-translational-systematic-review
#14
REVIEW
Tatiana Barichello, Pavani Sayana, Vijayasree V Giridharan, Anithachristy S Arumanayagam, Boomadevi Narendran, Amanda Della Giustina, Fabricia Petronilho, João Quevedo, Felipe Dal-Pizzol
Sepsis is systemic inflammatory response syndrome with a life-threatening organ dysfunction that is caused by an unbalanced host immune response in an attempt to eliminate invasive microorganisms. We posed questions, "Does sepsis survivor patients have increased risk of neuropsychiatric manifestations?" and "What is the mechanism by which sepsis induces long-term neurological sequelae, particularly substantial cognitive function decline in survivor patients and in pre-clinical sepsis models?" The studies were identified by searching PubMed/MEDLINE (National Library of Medicine), PsycINFO, EMBASE (Ovid), LILACS (Latin American and Caribbean Health Sciences Literature), IBECS (Bibliographical Index in Spanish in Health Sciences), and Web of Science databases for peer-reviewed journals that were published until January 2018...
April 23, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29686989/enhanced-recovery-after-surgery-protocols-in-major-urologic-surgery
#15
REVIEW
Natalija Vukovic, Ljubomir Dinic
The purpose of the review: The analysis of the components of enhanced recovery after surgery (ERAS) protocols in urologic surgery. Recent findings: ERAS protocols has been studied for over 20 years in different surgical procedures, mostly in colorectal surgery. The concept of improving patient care and reducing postoperative complications was also applied to major urologic surgery and especially procedure of radical cystectomy. This procedure is technically challenging, due to a major surgical resection and high postoperative complication rate that may reach 65%...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29686821/acute-effect-of-different-concentrations-of-cayenne-pepper-cataplasm-on-sensory-motor-functions-and-serum-levels-of-inflammation-related-biomarkers-in-healthy-subjects
#16
Nejc Sarabon, Stefan Löfler, Jan Cvecka, Wolfgang Hübl, Sandra Zampieri
Physical medicine therapies are often used in treating widespread musculoskeletal disorders, such as neck and low back pain. Herbal cataplasms containing rubefacient substances, such as Cayenne pepper, or galenic preparations like Munari cataplasm are commonly used as natural medications to treat painful areas. In this paper we show the effects of a 20-min application of Cayenne pepper and kaolin powder cataplasm (CPC) on healthy subjects. Treatment effects were evaluated by cold/hot feeling on visual analogue scale, blood pressure, body temperature, skin light touch sensations, two-point discrimination, and pain threshold to a mechanical stimulus, before and immediately after, 15 min after and 30 min after different concentration of Cayenne pepper in CPC preparation on healthy subjects...
January 12, 2018: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29686645/phantom-limb-pain-in-pediatric-oncology
#17
REVIEW
Patrick DeMoss, Logan H Ramsey, Cynthia Windham Karlson
Phantom limb pain (PLP) is a prevalent problem for children and adolescents undergoing amputation due to cancer treatment. The symptoms are wide ranging from sharp to tingling. PLP in children typically lasts for a few minutes but can be almost constant and can be highly distressing. This focused review describes the characteristics, epidemiology, mechanisms, and evidence-based treatment of PLP in pediatric populations, focusing on pediatric cancer. In pediatric oncology, the administration of chemotherapy is a risk factor that potentially sensitizes the nervous system and predisposes pediatric cancer patients to develop PLP after amputation...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29685837/outcomes-of-hip-arthroscopy-in-a-military-population-are-similar-to-those-in-the-civilian-population-matched-paired-analysis-at-2-years
#18
Jun-Il Yoo, Tae-Ho Lee, Jae-Yoon Kim, Jae-Hyung Kim, Yong-Chan Ha
PURPOSE: The purpose of this study was to compare the clinical outcomes, including the visual analog pain score, University of California Los Angeles activity, modified Harris hip score, and radiologic outcomes after hip arthroscopy in male patients whose symptoms developed during military services with those in a matched-pair control group of active young, nonmilitary patients at a minimum postoperative follow-up of 2 years. METHODS: From September 2009 to December 2014, 28 male patients with mechanical symptoms that developed during military service underwent hip arthroscopic surgery...
April 20, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29685565/decompressive-medial-cuneiform-exostectomy-for-resistant-tibialis-anterior-insertional-tendinopathy
#19
Alan J Laing, Christopher Carr
Distal tibialis anterior tendinopathy, as a clinical entity, has only recently been documented in foot and ankle studies. We report our experience with medial cuneiform decompressive exostectomy and superficial tendon debridement in 14 cases of recalcitrant tibilalis anterior insertional pain. We reviewed 13 patients (14 feet; 12 females, 1 male; mean age 67.9 ± 7.5; range 55 to 80 years) in whom conservative treatment had failed who had undergone debridement of the insertional tibialis anterior tendon and decompressive exostectomy of the medial cuneiform...
May 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29685500/evidence-of-generalised-mechanical-hyperalgesia-in-patients-with-advanced-knee-osteoarthritis-undergoing-total-knee-arthroplasty
#20
Khalid Jaber, Shaun O'Leary, Ashley Pedler, Michele Sterling, Michael McAuliffe
BACKGROUND AND OBJECTIVE: Persistent pain is reported in up to 34% of patients following total knee arthroplasty (TKA) for management of knee osteoarthritis (KOA). Persistent pain in this group is thought to be at least partly reflective of pain sensory hypersensitivity. The objective of this study was to evaluate sensory hypersensitivity, using mechanical and thermal quantitative sensory testing, in patients about to undergo TKA. DESIGN AND METHODS: Pressure pain thresholds (PPT) and cold pain thresholds (CPT) were recorded from 30 participants prior to their TKA, and compared with recordings taken from 30 healthy control participants of similar age and gender...
April 20, 2018: Knee
keyword
keyword
84742
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"