keyword
https://read.qxmd.com/read/38452858/quantifying-regional-radiation-induced-lung-injury-in-patients-using-hyperpolarized-xenon-129-gas-exchange-magnetic-resonance-imaging-assessing-rt-lung-injury-with-hp-xenon-gx-mri
#1
JOURNAL ARTICLE
Leith J Rankine, Junlan Lu, Ziyi Wang, Chris R Kelsey, Lawrence B Marks, Shiva K Das, Bastiaan Driehuys
PURPOSE: Radiation-induced lung injury (RILI) has been shown to alter regional ventilation and perfusion in the lung. However, changes in regional pulmonary gas exchange have not previously been measured. METHODS: Ten patients receiving conventional radiation therapy (RT) for lung cancer underwent pre-RT and 3-month post-RT MRI using an established hyperpolarized-129 Xe gas exchange technique to map lung function. Four patients underwent an additional 8-month post-RT MRI...
March 5, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38378325/phase-resolved-functional-lung-preful-mri-to-quantify-ventilation-feasibility-and-physiological-relevance-in-severe-asthma
#2
JOURNAL ARTICLE
Yonni Friedlander, Samal Munidasa, Ashutosh Thakar, Nandhitha Ragunayakam, Carmen Venegas, Melanie Kjarsgaard, Brandon Zanette, Dante P I Capaldi, Giles Santyr, Parameswaran Nair, Sarah Svenningsen
RATIONALE AND OBJECTIVES: Emergent evidence in several respiratory diseases supports translational potential for Phase-Resolved Functional Lung (PREFUL) MRI to spatially quantify ventilation but its feasibility and physiological relevance have not been demonstrated in patients with asthma. This study compares PREFUL-derived ventilation defect percent (VDP) in severe asthma patients to healthy controls and measures its responsiveness to bronchodilator therapy and relation to established measures of airways disease...
February 19, 2024: Academic Radiology
https://read.qxmd.com/read/38336440/-129-xe-mri-and-oscillometry-of-irritant-induced-asthma-after-bronchial-thermoplasty
#3
Marrissa J McIntosh, Joseph J Hofmann, Harkiran K Kooner, Rachel L Eddy, Grace Parraga, Constance A Mackenzie
Irritant-induced asthma (IIA) may develop after acute inhalational exposure in individuals without preexisting asthma. The effect of bronchial thermoplasty to treat intractable, worsening IIA has not yet been described. We evaluated a previously healthy 52-year-old man after inhalation of an unknown white powder. His pulmonary function and symptoms/quality of life worsened over 4 years, despite maximal guidelines-based asthma therapy. We acquired 129 Xe MRI and pulmonary function test measurements on three occasions including before and after bronchial thermoplasty treatment...
February 2024: Chest
https://read.qxmd.com/read/38233260/hyperpolarized-gas-imaging-in-lung-diseases-functional-and-artificial-intelligence-perspective
#4
REVIEW
Ziwei Zhang, Haidong Li, Sa Xiao, Qian Zhou, Shiyuan Liu, Xin Zhou, Li Fan
Pathophysiologic changes in lung diseases are often accompanied by changes in ventilation and gas exchange. Comprehensive evaluation of lung function cannot be obtained through chest X-ray and computed tomography. Proton-based lung MRI is particularly challenging due to low proton density within the lung tissue. In this review, we discuss an emerging technology--hyperpolarized gas MRI with inhaled 129 Xe, which provides functional and microstructural information and has the potential as a clinical tool for detecting the early stage and progression of certain lung diseases...
January 16, 2024: Academic Radiology
https://read.qxmd.com/read/38066737/voxel-wise-comparison-of-co-registered-quantitative-ct-and-hyperpolarised-gas-diffusion-weighted-mri-measurements-in-ipf
#5
JOURNAL ARTICLE
Ho-Fung Chan, Nicholas D Weatherley, Alberto M Biancardi, Christopher S Johns, Bilal A Tahir, Ronald A Karwoski, Brian J Bartholmai, Stephen M Bianchi, Jim M Wild
The patterns of idiopathic pulmonary fibrosis (IPF) lung disease that directly correspond to elevated hyperpolarised gas diffusion-weighted (DW) MRI metrics are currently unknown. This study aims to develop a spatial co-registration framework for a voxel-wise comparison of hyperpolarised gas DW-MRI and CALIPER quantitative CT patterns. Sixteen IPF patients underwent 3 He DW-MRI and CT at baseline, and eleven patients had a 1-year follow-up DW-MRI. Six healthy volunteers underwent 129 Xe DW-MRI at baseline only...
November 21, 2023: Diagnostics
https://read.qxmd.com/read/37977888/hyperpolarized-129-xe-mri-99m-tc-scintigraphy-and-spect-in-lung-ventilation-imaging-a-quantitative-comparison
#6
JOURNAL ARTICLE
J D Peiffer, Talissa Altes, Iulian C Ruset, F W Hersman, John P Mugler, Craig H Meyer, Jamie Mata, Kun Qing, Robert Thomen
RATIONALE AND OBJECTIVES: The current clinical standard for functional imaging of patients with lung ailments is nuclear medicine scintigraphy and Single Photon Emission Computed Tomography (SPECT) which detect the gamma decay of inhaled radioactive tracers. Hyperpolarized (HP) Xenon-129 MRI (XeMRI) of the lungs has recently been FDA approved and provides similar functional images of the lungs with higher spatial resolution than scintigraphy and SPECT. Here we compare Technetium-99m (99m Tc) diethylene-triamine-pentaacetate scintigraphy and SPECT with HP XeMRI in healthy controls, asthma, and chronic obstructive pulmonary disorder (COPD) patients...
November 15, 2023: Academic Radiology
https://read.qxmd.com/read/37948969/current-advances-in-pulmonary-functional-imaging
#7
REVIEW
Hidetoshi Nakamura, Toyohiro Hirai, Hajime Kurosawa, Kazuki Hamada, Kazuto Matsunaga, Kaoruko Shimizu, Satoshi Konno, Shigeo Muro, Koichi Fukunaga, Yasutaka Nakano, Ichiro Kuwahira, Masayuki Hanaoka
Recent advances in imaging analysis have enabled evaluation of ventilation and perfusion in specific regions by chest computed tomography (CT) and magnetic resonance imaging (MRI), in addition to modalities including dynamic chest radiography, scintigraphy, positron emission tomography (PET), ultrasound, and electrical impedance tomography (EIT). In this review, an overview of current functional imaging techniques is provided for each modality. Advances in chest CT have allowed for the analysis of local volume changes and small airway disease in addition to emphysema, using the Jacobian determinant and parametric response mapping with inspiratory and expiratory images...
January 2024: Respiratory Investigation
https://read.qxmd.com/read/37889567/functional-impairment-in-small-airways-associated-with-the-breathlessness-symptoms-in-long-coronavirus-disease
#8
JOURNAL ARTICLE
Minsuok Kim, Jeongeun Hwang, James T Grist, Gabriele Abueid, Soon Ho Yoon, Vicente Grau, Emily Fraser, Fergus V Gleeson
PURPOSE: This study aimed to determine the association between functional impairment in small airways and symptoms of dyspnea in patients with Long-coronavirus disease (COVID), using imaging and computational modeling analysis. PATIENTS AND METHODS: Thirty-four patients with Long-COVID underwent thoracic computed tomography and hyperpolarized Xenon-129 magnetic resonance imaging (HP Xe MRI) scans. Twenty-two answered dyspnea-12 questionnaires. We used a computed tomography-based full-scale airway network (FAN) flow model to simulate pulmonary ventilation...
October 9, 2023: Journal of Thoracic Imaging
https://read.qxmd.com/read/37548112/review-of-hyperpolarized-pulmonary-functional-129-xe-mr-for-long-covid
#9
REVIEW
Jim M Wild, Fergus V Gleeson, Sarah Svenningsen, James T Grist, Laura C Saunders, Guilhem J Collier, Maksym Sharma, Sam Tcherner, Ali Mozaffaripour, Alexander M Matheson, Grace Parraga
The respiratory consequences of acute COVID-19 infection and related symptoms tend to resolve 4 weeks post-infection. However, for some patients, new, recurrent, or persisting symptoms remain beyond the acute phase and persist for months, post-infection. The symptoms that remain have been referred to as long-COVID. A number of research sites employed 129 Xe magnetic resonance imaging (MRI) during the pandemic and evaluated patients post-infection, months after hospitalization or home-based care as a way to better understand the consequences of infection on 129 Xe MR gas-exchange and ventilation imaging...
August 7, 2023: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/37371626/hyperpolarized-xenon-129-a-new-tool-to-assess-pulmonary-physiology-in-patients-with-pulmonary-fibrosis
#10
JOURNAL ARTICLE
Kun Qing, Talissa A Altes, John P Mugler, Jaime F Mata, Nicholas J Tustison, Kai Ruppert, Juliana Bueno, Lucia Flors, Yun M Shim, Li Zhao, Joanne Cassani, William G Teague, John S Kim, Zhixing Wang, Iulian C Ruset, F William Hersman, Borna Mehrad
PURPOSE: The existing tools to quantify lung function in interstitial lung diseases have significant limitations. Lung MRI imaging using inhaled hyperpolarized xenon-129 gas (129 Xe) as a contrast agent is a new technology for measuring regional lung physiology. We sought to assess the utility of the 129 Xe MRI in detecting impaired lung physiology in usual interstitial pneumonia (UIP). MATERIALS AND METHODS: After institutional review board approval and informed consent and in compliance with HIPAA regulations, we performed chest CT, pulmonary function tests (PFTs), and 129 Xe MRI in 10 UIP subjects and 10 healthy controls...
May 25, 2023: Biomedicines
https://read.qxmd.com/read/36781102/ct-mucus-score-and-129xe-mri-ventilation-defects-after-2-5-years-anti-il-5r%C3%AE-in-eosinophilic-asthma
#11
JOURNAL ARTICLE
Marrissa J McIntosh, Harkiran K Kooner, Rachel L Eddy, Angela Wilson, Hana Serajeddini, Anurag Bhalla, Christopher Licskai, Constance A Mackenzie, Cory Yamashita, Grace Parraga
BACKGROUND: We previously showed in poorly controlled eosinophilic asthma patients that a single dose of benralizumab resulted in significantly improved asthma-control-questionnaire (ACQ-6) score and 129 Xe magnetic-resonance-imaging (MRI) ventilation defect percent (VDP), 28-days post-injection, and 129 Xe MRI VDP and computed tomography (CT) airway mucus occlusions were shown to independently predict this early ACQ-6 response to benralizumab. RESEARCH QUESTION: Do early VDP responses at 28-days persist and do FEV1 , FeNO and mucus-plug score improve during a 2...
February 11, 2023: Chest
https://read.qxmd.com/read/36752590/mr-imaging-of-the-airways
#12
REVIEW
Juergen Biederer
The need for airway imaging is defined by the limited sensitivity of common clinical tests like spirometry, lung diffusion (DLCO) and blood gas analysis to early changes of peripheral airways and to inhomogeneous regional distribution of lung function deficits. Therefore, X-ray and computed tomography (CT) are frequently used to complement the standard tests.As an alternative, magnetic resonance imaging (MRI) offers radiation-free lung imaging, but at lower spatial resolution. Non-contrast enhanced MRI shows healthy airways down to the first subsegmental level/4th order (CT: eighth)...
June 1, 2023: British Journal of Radiology
https://read.qxmd.com/read/36596692/longitudinal-follow-up-of-postacute-covid-19-syndrome-dl-co-quality-of-life-and-mri-pulmonary-gas-exchange-abnormalities
#13
JOURNAL ARTICLE
Alexander M Matheson, Marrissa J McIntosh, Harkiran K Kooner, Mohamed Abdelrazek, Mitchell S Albert, Inderdeep Dhaliwal, J Michael Nicholson, Alexei Ouriadov, Sarah Svenningsen, Grace Parraga
129 Xe MRI red blood cell to alveolar tissue plasma ratio (RBC:TP) abnormalities have been observed in ever-hospitalised and never-hospitalised people with postacute COVID-19 syndrome (PACS). But, it is not known if such abnormalities resolve when symptoms and quality-of-life scores improve. We evaluated 21 participants with PACS, 7±4 months (baseline) and 14±4 months (follow-up) postinfection. Significantly improved diffusing capacity of the lung for carbon monoxide (DLCO , Δ=14%pred ;95%CI 7 to 21, p<0...
January 3, 2023: Thorax
https://read.qxmd.com/read/36419344/xenon-enhanced-dual-energy-tomosynthesis-for-functional-imaging-of-respiratory-disease-concept-and-phantom-study
#14
JOURNAL ARTICLE
Jesse Tanguay, Fateen Basharat
BACKGROUND: Xenon-enhanced dual-energy (DE) computed tomography and hyperpolarized noble-gas magnetic resonance imaging (MRI) provide maps of lung ventilation that can be used to detect chronic obstructive pulmonary disease (COPD) early in its development and predict respiratory exacerbations. However, xenon-enhanced DE computed tomography requires high radiation doses and hyper-polarized noble-gas MRI is expensive and only available at a handful of institutions globally. PURPOSE: To present xenon-enhanced dual-energy tomosynthesis (XeDET) for low-dose, low-cost functional imaging of respiratory disease in an experimental phantom study...
November 23, 2022: Medical Physics
https://read.qxmd.com/read/36399637/methods-to-expose-subsurface-objects-of-interest-identified-from-3d-imaging-the-intermediate-sample-preparation-stage-in-the-correlative-microscopy-workflow
#15
JOURNAL ARTICLE
R L Mitchell, T Dunlop, T Volkenandt, J Russell, P Davies, S Spooner, C Pleydell-Pearce, R Johnston
The correlative imaging workflow is a method of combining information and data across modes (e.g., SEM, X-ray CT, FIB-SEM), scales (cm-to-nm) and dimensions (2D-3D-4D), providing a more holistic interpretation of the research question. Often, subsurface objects of interest (e.g. inclusions, pores, cracks, defects in multi-layered samples) are identified from initial exploratory non-destructive 3D tomographic imaging (e.g. X-ray CT, XRM), and those objects need to be studied using additional techniques to obtain, for example, 2D chemical or crystallographic data...
November 18, 2022: Journal of Microscopy
https://read.qxmd.com/read/35959863/effect-of-dentine-site-on-resin-and-cement-adaptation-tested-using-x-ray-and-electron-microscopy-to-evaluate-bond-durability-and-adhesive-interfaces
#16
JOURNAL ARTICLE
Arosha Tania Weerakoon, Crystal Cooper, Kamil Andrzej Sokolowski, Ian Arthur Meyers, David Thomson, Pauline Jane Ford, Christopher Sexton, Anne Louise Symons
Glass ionomer (GI) cements and self-etch (SE) or universal adhesives after etching (ER) adapt variably with dentine. Dentine characteristics vary with depth (deep/shallow), location (central/peripheral), and microscopic site (intertubular/peritubular). To directly compare adhesion to dentine, non-destructive imaging and testing are required. Here, GI, ER, and SE adapted at different dentine depths, locations, and sites were investigated using micro-CT, xenon plasma focused ion beam scanning electron microscopy (Xe PFIB-SEM), and energy dispersive X-ray spectroscopy (EDS)...
August 12, 2022: European Journal of Oral Sciences
https://read.qxmd.com/read/35915784/omicron-sars-cov-2-epidemic-in-england-during-february-2022-a-series-of-cross-sectional-community-surveys
#17
JOURNAL ARTICLE
Marc Chadeau-Hyam, David Tang, Oliver Eales, Barbara Bodinier, Haowei Wang, Jakob Jonnerby, Matthew Whitaker, Joshua Elliott, David Haw, Caroline E Walters, Christina Atchison, Peter J Diggle, Andrew J Page, Deborah Ashby, Wendy Barclay, Graham Taylor, Graham Cooke, Helen Ward, Ara Darzi, Christl A Donnelly, Paul Elliott
Background: The Omicron wave of COVID-19 in England peaked in January 2022 resulting from the rapid transmission of the Omicron BA.1 variant. We investigate the spread and dynamics of the SARS-CoV-2 epidemic in the population of England during February 2022, by region, age and main SARS-CoV-2 sub-lineage. Methods: In the REal-time Assessment of Community Transmission-1 (REACT-1) study we obtained data from a random sample of 94,950 participants with valid throat and nose swab results by RT-PCR during round 18 (8 February to 1 March 2022)...
October 2022: The Lancet regional health. Europe
https://read.qxmd.com/read/35880982/hyperpolarized-129-xe-mr-spectroscopy-in-the-lung-shows-1-year-reduced-function-in-idiopathic-pulmonary-fibrosis
#18
JOURNAL ARTICLE
Andrew D Hahn, Katie J Carey, Gregory P Barton, Luis A Torres, Jeff Kammerman, Robert V Cadman, Kristine E Lee, Mark L Schiebler, Nathan Sandbo, Sean B Fain
Background Idiopathic pulmonary fibrosis (IPF) is a temporally and spatially heterogeneous lung disease. Identifying whether IPF in a patient is progressive or stable is crucial for treatment regimens. Purpose To assess the role of hyperpolarized (HP) xenon 129 (129 Xe) MRI measures of ventilation and gas transfer in IPF generally and as an early signature of future IPF progression. Materials and Methods In a prospective study, healthy volunteers and participants with IPF were consecutively recruited between December 2015 and August 2019 and underwent baseline HP 129 Xe MRI and chest CT...
July 26, 2022: Radiology
https://read.qxmd.com/read/35842879/higher-intracranial-pressure-variability-is-associated-with-lower-cerebrovascular-resistance-in-aneurysmal-subarachnoid-hemorrhage
#19
JOURNAL ARTICLE
Teodor Svedung Wettervik, Henrik Engquist, Timothy Howells, Anders Hånell, Elham Rostami, Elisabeth Ronne-Engström, Anders Lewén, Per Enblad
Higher intracranial pressure variability (ICPV) has been associated with a more favorable cerebral energy metabolism, lower rate of delayed ischemic neurologic deficits, and more favorable outcome in aneurysmal subarachnoid hemorrhage (aSAH). We have hypothesized that higher ICPV partly reflects more compliant and active cerebral vessels. In this study, the aim was to further test this by investigating if higher ICPV was associated with lower cerebrovascular resistance (CVR) and higher cerebral blood flow (CBF) after aSAH...
July 17, 2022: Journal of Clinical Monitoring and Computing
https://read.qxmd.com/read/35762891/persistent-129-xe-mri-pulmonary-and-ct-vascular-abnormalities-in-symptomatic-individuals-with-post-acute-covid-19-syndrome
#20
JOURNAL ARTICLE
Alexander M Matheson, Marrissa J McIntosh, Harkiran K Kooner, Justin Lee, Vedanth Desaigoudar, Elianna Bier, Bastiaan Driehuys, Sarah Svenningsen, Giles E Santyr, Miranda Kirby, Mitchell S Albert, Yurii Shepelytskyi, Vira Grynko, Alexei Ouriadov, Mohamed Abdelrazek, Inderdeep Dhaliwal, J Michael Nicholson, Grace Parraga
Background In patients with post-acute COVID-19-syndrome (PACS), abnormal gas-transfer and pulmonary vascular density have been reported, but such findings have not been related to each other, or to symptoms and exercise limitation. The pathophysiological drivers of PACS in ever- and never-hospitalized patients are not well-understood. Purpose To determine the relationship of persistent symptoms and exercise limitation with 129 Xe MRI and CT pulmonary vascular measurements in individuals with PACS. Materials and Methods In this prospective study, patients with PACS aged 18-80 years with a positive PCR COVID test were recruited from a quaternary-care COVID-19 clinic between April and October 2021...
June 28, 2022: Radiology
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