keyword
https://read.qxmd.com/read/37193464/prevalence-of-iatrogenic-vitamin-d-toxicity-among-the-saudi-population-of-vitamin-d-users-due-to-overcorrection
#21
JOURNAL ARTICLE
Faisal Aljehani, Mohammed B Qashqari, Mohammed K Alghamdi, Abdalaziz I Saadi, Mohamed Y Alreasini, Enad Alsolami, Mohammed Alfawaz
Background Despite abundant sunlight exposure, vitamin D deficiency remains a major challenge in Saudi Arabia. Meanwhile, the widespread use of vitamin D supplements has prompted concerns about toxicity, which although rare, can have severe health consequences. Objective The objective of this cross-sectional study was to analyze the prevalence and associated factors of iatrogenic vitamin D toxicity among the Saudi population of vitamin D users due to overcorrection. Methods An online questionnaire was used to collect data from 1,677 participants across all regions of Saudi Arabia...
April 2023: Curēus
https://read.qxmd.com/read/37123896/vitamin-d-reduces-pain-and-cartilage-destruction-in-knee-osteoarthritis-animals-through-inhibiting-the-matrix-metalloprotease-mmps-expression
#22
JOURNAL ARTICLE
Prabhakar Busa, Niancih Huang, Yaswanth Kuthati, Chih-Shung Wong
AIM OF THE STUDY: In this study, we investigated the therapeutic potential of vitamin D (VITD) in OA Wistar rats induced by anterior cruciate ligament transection combined with medial meniscectomy (ACLT + MMx). In ACLT + MMx-induced OA rats, pain severity, cartilage destruction, inflammatory cytokines, and MMPs were all measured. MATERIALS AND METHODS: ACLT + MMx methods were used to induce OA, and pain behavioral studies such as the weight bearing test and paw withdrawal test were performed while the knee width and body weights were also measured...
April 2023: Heliyon
https://read.qxmd.com/read/37040165/4-deoxypyridoxine-disrupts-vitamin-b-6-homeostasis-in-escherichia-coli-k12-through-combined-inhibition-of-cumulative-b-6-uptake-and-plp-dependent-enzyme-activity
#23
JOURNAL ARTICLE
Jill Babor, Angela Tramonti, Caterina Nardella, Adam Deutschbauer, Roberto Contestabile, Valérie de Crécy-Lagard
Pyridoxal 5'-phosphate (PLP) is the active form of vitamin B6 and a cofactor for many essential metabolic processes such as amino acid biosynthesis and one carbon metabolism. 4'-deoxypyridoxine (4dPN) is a long known B6 antimetabolite but its mechanism of action was not totally clear. By exploring different conditions in which PLP metabolism is affected in the model organism Escherichia coli K12, we showed that 4dPN cannot be used as a source of vitamin B6 as previously claimed and that it is toxic in several conditions where vitamin B6 homeostasis is affected, such as in a B6 auxotroph or in a mutant lacking the recently discovered PLP homeostasis gene, yggS ...
April 2023: Microbiology
https://read.qxmd.com/read/36981076/magnolol-loaded-on-carboxymethyl-chitosan-particles-improved-the-antimicrobial-resistance-and-storability-of-kiwifruits
#24
JOURNAL ARTICLE
Feixu Mo, Wenzhi Li, Youhua Long, Rongyu Li, Yi Ding, Ming Li
Magnolol is a natural compound extracted from the traditional Chinese medicine Magnolia officinalis , which exhibits antimicrobial properties. However, magnolol is insoluble in water and consists of a phenolic hydroxyl group, which is volatile; these factors hinder its application. In this study, a safe and environmentally friendly method to improve the microbial resistance and storability of harvested fruits is developed using the water-soluble carrier carboxymethyl chitosan (CMCS) and magnolol. Magnolol was loaded on CMCS particles to form Magnolol@CMCS antimicrobial particles, a preservation coating agent...
March 8, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/36923841/curcumin-and-vitamin-c-improve-immunity-of-kidney-via-gene-expression-against-diethyl-nitrosamine-induced-nephrotoxicity-in-rats-in-vivo-and-molecular-docking-studies
#25
JOURNAL ARTICLE
Ahmed B M Mehany, Islam M Farrag, Mahmoud Diab, Mohammed M Ghoneim, Mohamed El-Sherbiny, Rasha Hamed Al-Serwi, Ali H Amin, Amany Belal, Salwa Shaaban, Alsayed A Abdelhady
Kidney has a crucial role in immunity, so any toxicity occurs for the kidney will result in reduced immunity. The aim of this study is to improve the immune response of insufficient kidneys through immune-related genes. Diethyl Nitrosamine has been used to cause kidney damage in animal models, vitamin C and curcumin have been used to treat impaired kidney. Renal function (urea, uric acid and creatinine) and oxidative stress parameters (superoxide dismutase, malondialdehyde and glutathione peroxidase) will be evaluated in this research work...
March 2023: Heliyon
https://read.qxmd.com/read/36689866/placental-transcriptomic-signatures-of-prenatal-exposure-to-hydroxy-polycyclic-aromatic-hydrocarbons
#26
JOURNAL ARTICLE
Alison G Paquette, Samantha Lapehn, Sophie Freije, James MacDonald, Theo Bammler, Drew B Day, Christine T Loftus, Kurunthachalam Kannan, W Alex Mason, Nicole R Bush, Kaja Z LeWinn, Daniel A Enquobahrie, Carmen Marsit, Sheela Sathyanarayana
BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants originating from petrogenic and pyrogenic sources. PAH compounds can cross the placenta, and prenatal PAH exposure is linked to adverse infant and childhood health outcomes. OBJECTIVE: In this first human transcriptomic assessment of PAHs in the placenta, we examined associations between prenatal PAH exposure and placental gene expression to gain insight into mechanisms by which PAHs may disrupt placental function...
January 18, 2023: Environment International
https://read.qxmd.com/read/36669281/toxicity-enhancement-of-nano-titanium-dioxide-to-brachionus-calyciflorus-rotifera-under-simulated-sunlight-and-the-underlying-mechanisms
#27
JOURNAL ARTICLE
Liu Yang, Jinqian Xu, Huahua Gao, Shiniu Dai, Lingli Liu, Yilong Xi, Gen Zhang, Xinli Wen
Nano titanium dioxide (nTiO2 ) generally shows low toxicity to organisms under light-emitting diode (LED) light. However, nTiO2 can induce production of reactive oxygen species (ROS) under ultraviolet (UV) light due to its photocatalytic activity. Therefore, it is reasonable to expect the enhancement of nTiO2 toxicity under sunlight. To test this hypothesis, we compared the toxicity of nTiO2 to Brachionus calyciflorus under simulated sunlight and LED light. The results showed that the 24 h-LC50 of nTiO2 to B...
January 18, 2023: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/36525104/dietary-supplement-use-and-recommendations-for-discontinuation-in-an-integrative-oncology-clinic
#28
JOURNAL ARTICLE
Stacy D D'Andre, Brent A Bauer, Margaret B Hofmann, Jenna L Burckhard, Heather N Montane, Charles L Loprinzi
PURPOSE: This project evaluated the dietary supplement (DS) use of patients referred to an integrative oncology program and documented the frequency and reasons for recommending stopping DS. Many patients with cancer are taking dietary supplements and may not disclose such to their care teams. There is potential for harm in several ways: (1) interactions with their medications that may increase side effects, (2) interactions with their treatment that may lead to decreased efficacy, and 3) direct toxicity from the supplement...
December 16, 2022: Supportive Care in Cancer
https://read.qxmd.com/read/36471898/a-comprehensive-and-mechanistic-review-on-protective-effects-of-kaempferol-against-natural-and-chemical-toxins-role-of-nf-%C3%AE%C2%BAb-inhibition-and-nrf2-activation
#29
REVIEW
Azar Hosseini, Alieh Alipour, Vafa Baradaran Rahimi, Vahid Reza Askari
Different toxins, including chemicals and natural, can be entered from various routes and influence human health. Herbal medicines and their active components can attenuate the toxicity of agents via multiple mechanisms. For example, kaempferol, as a flavonoid, can be found in fruits and vegetables, and has an essential role in improving disorders such as cardiovascular disorders, neurological diseases, cancer, pain, and inflammation situations. The beneficial effects of kaempferol may be related to the inhibition of oxidative stress, attenuation of inflammatory factors such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), cyclooxygenase-2 (COX-2) and nuclear factor ĸB (NF-ĸB) as well as the modulation of apoptosis and mitogen-activated protein kinase (MAPK) signaling pathways...
December 5, 2022: BioFactors
https://read.qxmd.com/read/36325173/the-effect-of-vitamin-b-6-in-the-prevention-of-hematological-adverse-effects-of-linezolid-in-patients-with-chronic-osteomyelitis-a-randomized-double-blind-placebo-controlled-clinical-trial
#30
JOURNAL ARTICLE
Kiana Shirani, Farzin Khorvash, Rasool Soltani, Behrooz Ataie, Mohammad Javad Tarrahi, Farideh Fallah
Background: Due to the contradictory results of the effects of Vitamin B6 in reducing the hematotoxic effects of linezolid, the present study aimed to investigate the possible role of Vitamin B6 administration in reducing linezolid-related hematological toxicities in patients with chronic osteomyelitis. Materials and Methods: In a randomized double-blind placebo-controlled clinical trial, patients with chronic osteomyelitis were randomly divided into two groups (n = 40 each): the intervention group received Vitamin B6 40 mg twice daily from the beginning of treatment with linezolid and the control group received placebo with linezolid, both for 21 days...
2022: Advanced Biomedical Research
https://read.qxmd.com/read/36179447/effects-of-copper-accumulation-on-growth-and-development-of-scopelophila-cataractae-grown-in-vitro
#31
JOURNAL ARTICLE
Narin Printarakul, Kanonrat Adulkittichai, Weeradej Meeinkuirt
Scopelophila cataractae was cultured in vitro for 16 weeks to assess the contrasting effects of Cu on growth and reproduction, as well as gametophore stage. To induce buds and gametophores of S. cataractae, ten treatments (tr 1 to tr 10) of culture media were prepared using a combination of mineral salts, sugar, vitamin B complex, CuSO4 , and exogenous hormones. Highest numbers of gametophores and buds were formed in media containing 500 µM CuSO4 in co-application with auxin and cytokinin, as shown in the modest Cu treatments (tr 6 and tr 7, 26 per cushion and 255 per 25 mm2 , respectively)...
September 27, 2022: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/35944603/vitamin-d-insufficiency-and-clinical-outcomes-with-chimeric-antigen-receptor-t-cell-therapy-in-large-b-cell-lymphoma
#32
JOURNAL ARTICLE
Karthik Nath, Ana Alarcon Tomas, Jessica Flynn, Joshua A Fein, Anna Alperovich, Theodora Anagnostou, Connie Lee Batlevi, Parastoo B Dahi, Warren B Fingrut, Sergio A Giralt, Richard J Lin, M Lia Palomba, Jonathan U Peled, Gilles Salles, Craig S Sauter, Michael Scordo, Ellen Fraint, Elise Feuer, Nishi Shah, John B Slingerland, Sean Devlin, Gunjan L Shah, Gaurav Gupta, Miguel-Angel Perales, Roni Shouval
Vitamin D insufficiency is a potentially modifiable risk factor for poor outcomes in newly diagnosed large B-cell lymphoma (LBCL). However, the role of circulating vitamin D concentrations in relapsed/refractory LBCL treated with CD19-directed chimeric antigen receptor T-cell therapy (CAR-T) is currently unknown. This was a single-center, observational study that evaluated the association of pre-CAR-T 25-hydroxyvitamin D (25-OHD) status with 100-day complete response, progression-free survival, overall survival, and CAR-T-related toxicity in 111 adult relapsed/refractory LBCL patients...
August 6, 2022: Transplantation and cellular therapy
https://read.qxmd.com/read/35780875/implications-for-the-seafood-industry-consumers-and-the-environment-arising-from-contamination-of-shellfish-with-pharmaceuticals-plastics-and-potentially-toxic-elements-a-case-study-from-irish-waters-with-a-global-orientation
#33
REVIEW
Gustavo Waltzer Fehrenbach, Robert Pogue, Frank Carter, Eoghan Clifford, Neil Rowan
Shellfish are a rich source of minerals, B-vitamins and omega-3 to the human diet. The global population is expected to reach 9.6 billion people by 2050 where there will be increased demand for shellfish and for sustained improvements in harvesting. The production of most consumed species of shellfish is sea-based and are thus susceptible to in situ environmental conditions and water quality. Population growth has contributed to expansion of urbanization and the generation of effluent and waste that reaches aquatic environments, potentially contaminating seafood by exposure to non-treated effluents or inappropriately discarded waste...
October 20, 2022: Science of the Total Environment
https://read.qxmd.com/read/35774994/case-report-early-recognition-treatment-and-occupational-safety-protection-are-crucial-for-methanol-toxicity
#34
Xiaomei Wu, Meifeng Gu, Wei Wang, Hainan Zhang, Zhenchu Tang
Background: Despite significant progress in treating methanol poisoning, the lack of training, hazard communication, and occupational safety protection education contributes to the risk of occupational exposure and methanol toxicity. In addition, early diagnosis and timely medical care are essential to reduce the risk of morbidity and mortality, yet it remains a challenging procedure. Case Report: A 35-year-old man working in a fireworks factory came to our emergency department with acute mental change and progressive disturbance of consciousness...
2022: Frontiers in Medicine
https://read.qxmd.com/read/35740030/is-there-an-optimal-combination-of-areds2-antioxidants-zeaxanthin-vitamin-e-and-vitamin-c-on-light-induced-toxicity-of-vitamin-a-aldehyde-to-the-retina
#35
JOURNAL ARTICLE
Małgorzata B Różanowska, Barbara Czuba-Pełech, Bartosz Różanowski
Vitamins C and E and zeaxanthin are components of a supplement tested in a large clinical trial-Age-Related Eye Disease Study 2 (AREDS2)-and it has been demonstrated that they can inhibit the progression of age-related macular degeneration. The aim of this study was to determine the optimal combinations of these antioxidants to prevent the phototoxicity mediated by vitamin A aldehyde (ATR), which can accumulate in photoreceptor outer segments (POS) upon exposure to light. We used cultured retinal pigment epithelial cells ARPE-19 and liposomes containing unsaturated lipids and ATR as a model of POS...
June 9, 2022: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/35721668/the-anti-cytokine-storm-activity-of-quercetin-zinc-and-vitamin-c-complex
#36
JOURNAL ARTICLE
Hayder B Sahib, Omer Abid Kathum, Rafal Shakeeb Alanee, Rehab A M Jawad, Ahmed Majeed Al-Shammari
Cytokine storm is one of the causative deaths in a patient with severe acute respiratory syndrome. This study aimed at evaluating the prophylaxis effect of quercetin complexes with zinc and buffered ascorbic acid upon cytokine storm induction in mice and identifying the complex's acute toxicity. Mice were randomly divided into three groups: group A, control group, received 0.9% normal saline; group B received 100 mg/kg of the complex one hour before lipopolysaccharide (LPS) administration; and group C received the LPS IP 5 mg/kg...
2022: Advances in Virology
https://read.qxmd.com/read/35401022/a-glyphosate-based-herbicide-disrupted-hematopoiesis-and-induced-organ-toxicities-ameliorated-by-vitamin-b-12-in-a-mouse-model
#37
JOURNAL ARTICLE
Douglas Ngatuni, Peninah Wairagu, Ngalla Jillani, Alfred Orina Isaac, James Nyabuga Nyariki
Glyphosate-based herbicides (GBH) are widely used worldwide. Their negative impact on human health is a matter of debate by regulatory bodies and the public. The present study sought to determine the impact of a GBH on the vital organs; and the potential protective effects of vitamin B12 (cyanocobalamin) supplementation. Sixty white Swiss mice were randomly assigned to five treatment groups, each containing twelve mice. Group one represented the normal control; Group two mice were treated with 375 mg/kg of GBH for 56 days; Group three mice received 10 mg/kg of cyanocobalamin for 56 days; Group four mice were administered with 375 mg/kg of GBH and 10 mg/kg cyanocobalamin for 56 days and Group five received 10 mg/kg cyanocobalamin first for 7 days, then continued thereafter co-administered together with 375 mg/kg of GBH for 56 days)...
June 2022: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/35364806/the-alleviative-efficacy-of-vitamins-a-c-and-e-against-zinc-oxide-nanoparticles-induced-hepatic-damage-by-reducing-apoptosis-in-rats
#38
JOURNAL ARTICLE
Sajedeh Daei, Roghayeh Abbasalipourkabir, Maryam Khajvand-Abedini, Nasrin Ziamajidi
Nanoparticles are vastly exploited in today's technology. However, it is realized that exposure to high concentrations of nanoparticles (NPs) may have adverse effects on human health. According to previous reports, zinc oxide (ZnO) NPs cause toxic effects in tissues via inducing apoptosis. The current work was designed to evaluate possible protective activities of vitamins (Vits) A, C, and E against ZnO NPs-induced apoptosis in the liver of rats. To this aim, fifty-four adult male Wistar rats were randomly distributed into nine groups (n = 6 rats for each group), namely, Control1 (water), Control2 (olive oil), Vit A (1000 IU/kg), Vit C (200 mg/kg), Vit E (100 IU/kg), ZnO (200 mg/kg), ZnO + VitA, ZnO + VitC, and ZnO + VitE...
April 1, 2022: Biological Trace Element Research
https://read.qxmd.com/read/35099985/genetic-analysis-using-vitamin-b-6-antagonist-4-deoxypyridoxine-uncovers-a-connection-between-pyridoxal-5-phosphate-and-coenzyme-a-metabolism-in-salmonella-enterica
#39
JOURNAL ARTICLE
Huong N Vu, Diana M Downs
Pyridoxal 5'-phosphate (PLP) is an essential cofactor for organisms in all three domains of life. Despite the central role of PLP, many aspects of vitamin B6 metabolism, including its integration with other biological pathways, are not fully understood. In this study, we examined the metabolic perturbations caused by the vitamin B6 antagonist 4-deoxypyridoxine (dPN) in a ptsJ mutant of Salmonella enterica serovar Typhimurium LT2. Our data suggest that PdxK (pyridoxal/pyridoxine/pyridoxamine kinase [EC 2.7.1...
March 15, 2022: Journal of Bacteriology
https://read.qxmd.com/read/35099041/cisplatin-induced-alterations-in-the-blood-nerve-barrier-effects-of-combination-of-vitamin-b1-b6-and-b12
#40
JOURNAL ARTICLE
A Tothonglor, P Kobutree, A Roumwong, D Jindatip, S Agthong
Cisplatin is a chemotherapeutic agent against solid cancers. However, neuropathy is a major side effect and has no effective treatment so far. Emerging evidence suggests that cisplatin might damage nerve capillaries leading to impaired blood-nerve barrier (BNB). This study aimed to investigate the ultrastructural changes of the BNB in the sciatic nerves and dorsal root ganglia of rats with cisplatin neuropathy and the effects of B₁₋₆₋₁₂. The results showed that cisplatin 2 mg/kg injected intraperitoneally twice a week for 5 consecutive weeks caused thermal hypoalgesia and structural abnormalities of nerves and ganglia...
January 31, 2022: Folia Morphologica (Warsz)
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