Karthik Nath, Ana Alarcon Tomas, Jessica Flynn, Joshua A Fein, Anna Alperovich, Theodora Anagnostou, Connie Lee Batlevi, Parastoo B Dahi, Warren B Fingrut, Sergio A Giralt, Richard J Lin, M Lia Palomba, Jonathan U Peled, Gilles Salles, Craig S Sauter, Michael Scordo, Ellen Fraint, Elise Feuer, Nishi Shah, John B Slingerland, Sean Devlin, Gunjan L Shah, Gaurav Gupta, Miguel-Angel Perales, Roni Shouval
Vitamin D insufficiency is a potentially modifiable risk factor for poor outcomes in newly diagnosed large B-cell lymphoma (LBCL). However, the role of circulating vitamin D concentrations in relapsed/refractory LBCL treated with CD19-directed chimeric antigen receptor T-cell therapy (CAR-T) is currently unknown. This was a single-center, observational study that evaluated the association of pre-CAR-T 25-hydroxyvitamin D (25-OHD) status with 100-day complete response, progression-free survival, overall survival, and CAR-T-related toxicity in 111 adult relapsed/refractory LBCL patients...
August 6, 2022: Transplantation and cellular therapy