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Vitamin B 6 toxicity

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https://www.readbyqxmd.com/read/27756753/benefits-of-multifaceted-chemopreventives-in-the-suppression-of-the-oral-squamous-cell-carcinoma-oscc-tumorigenic-phenotype
#1
Susan R Mallery, Daren Wang, Brian Santiago, Ping Pei, Steven Schwendeman, Kari Nieto, Richard Spinney, Meng Tong, George Koutras, Byungdo B Han, Andrew S Holpuch, James C Lang
Over 1/3 of patients who have undergone oral squamous cell carcinoma (OSCC) surgical resections develop life-threatening and often untreatable recurrences. A variety of drugs, intended for management of recurrent or disseminated cancers, were designed to exploit cancer cells' reliance upon overexpressed receptors and gratuitous signaling. Despite their conceptual promise, clinical trials showed these agents lacked efficacy and were often toxic. These findings are consistent with evasion of pathway-targeted treatments via extensive signaling redundancies and compensatory mechanisms common to cancers...
October 18, 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27749260/vitamin-c-pretreatment-protects-from-nickel-induced-acute-nephrotoxicity-in-mice
#2
Imed-Eddine Kadi, Faouzi Dahdouh
Nickel is an abundant carcinogenic and nephrotoxic metal whose activity leads to renal impairment. Previous studies have shown a protective effect of simultaneous vitamin C administration on acute and chronic nickel toxicity. However, very little research relating to the effect of vitamin C pretreatment in preventing nickel-induced acute nephrotoxicity is available. Therefore, the present study aimed to determine the efficiency of vitamin C (VC) pretreatment in preventing acute renal toxicity of nickel. Mice were pretreated orally with vitamin C (16...
September 1, 2016: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/27739306/vitamin-b6-tethered-endosomal-ph-responsive-lipid-nanoparticles-for-triggered-intracellular-release-of-doxorubicin
#3
Shweta Sharma, Ashwni Kumar Verma, Jyotsana Singh, B Venkatesh Teja, Naresh Mittapelly, Gitu Pandey, Sandeep Urandur, Ravi Shukla, Rituraj Konwar, Prabhat Ranjan Mishra
This study reports the development of Vitamin B6 (VitB6) modified pH sensitive charge reversal nanoparticles for efficient intracellular delivery of Doxorubicin (DOX). Herein, VitB6 was conjugated to stearic acid and the nanoparticles of the lipid were formulated by solvent injection method (DOX-B6-SA-NP). Due to the pKa (5.6) of VitB6, DOX-B6-SA-NP showed positive charge and enhanced release of DOX at pH 5. Confocal microscopy illustrated that DOX-B6-SA-NP treatment keep higher DOX accumulation inside the cells that conventional pH insensitive lipid nanoparticles (DOX-SA-NP)...
October 14, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27603551/effects-of-commonly-used-chronic-medications-on-the-outcomes-of-ipilimumab-therapy-in-patients-with-metastatic-melanoma
#4
Jarrett J Failing, Heidi D Finnes, Lisa A Kottschade, Jacob B Allred, Svetomir N Markovic
Ipilimumab can induce long-term survival in 20% of patients with metastatic melanoma. Concurrent chronic medications may impact the patient's immune system, possess antimelanoma properties, and potentially affect clinical outcomes. This retrospective study sought to describe the efficacy and toxicity effects of 12 classes of chronic medications in metastatic melanoma patients treated with ipilimumab. A total of 159 adults who received ipilimumab for metastatic melanoma at Mayo Clinic (Rochester, Minnesota, USA) from 1 March 2011 through 31 December 2014 were included...
September 3, 2016: Melanoma Research
https://www.readbyqxmd.com/read/27582365/alcoholic-cardiomyopathy-the-result-of-dosage-and-individual-predisposition
#5
B Maisch
The individual amount of alcohol consumed acutely or chronically decides on harm or benefit to a person's health. Available data suggest that one to two drinks in men and one drink in women will benefit the cardiovascular system over time, one drink being 17.6 ml 100 % alcohol. Moderate drinking can reduce the incidence and mortality of coronary artery disease, heart failure, diabetes, ischemic and hemorrhagic stroke. More than this amount can lead to alcoholic cardiomyopathy, which is defined as alcohol toxicity to the heart muscle itself by ethanol and its metabolites...
September 2016: Herz
https://www.readbyqxmd.com/read/27511929/biomarkers-of-nutrition-for-development-bond-vitamin-a-review
#6
REVIEW
Sherry A Tanumihardjo, Robert M Russell, Charles B Stephensen, Bryan M Gannon, Neal E Craft, Marjorie J Haskell, Georg Lietz, Kerry Schulze, Daniel J Raiten
The Biomarkers of Nutrition for Development (BOND) project is designed to provide evidence-informed advice to anyone with an interest in the role of nutrition in health. The BOND program provides information with regard to selection, use, and interpretation of biomarkers of nutrient exposure, status, function, and effect, which will be especially useful for readers who want to assess nutrient status. To accomplish this objective, expert panels are recruited to evaluate the literature and to draft comprehensive reports on the current state of the art with regard to specific nutrient biology and available biomarkers for assessing nutritional status at the individual and population levels...
September 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27497728/zidovudine-and-isoniazid-induced-liver-toxicity-and-oxidative-stress-evaluation-of-mitigating-properties-of-silibinin
#7
Ramanathan Raghu, Sivanesan Karthikeyan
HIV/AIDS patients are more prone for opportunistic TB infections and they are administered the combined regimen of anti-retroviral drug zidovudine (AZT) and isoniazid (INH) for therapy. However, AZT+INH treatment has been documented to induce injury and remedial measures to prevent this adversity are not clearly defined. Silibinin (SBN) is a natural hepatoprotective principle isolated from medicinal plant Silybum marianum and is currently used for therapy of various liver diseases. This study investigate the hepatotoxic potentials of AZT alone, INH alone and AZT+INH treatments and the mitigating potentials of SBN against these drugs induced toxic insults of liver in rats...
September 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27423638/targeted-photocytotoxicity-by-copper-ii-complexes-having-vitamin-b6-and-photoactive-acridine-moieties
#8
Nandini Mukherjee, Santosh Podder, Samya Banerjee, Shamik Majumdar, Dipankar Nandi, Akhil R Chakravarty
Copper(II) pyridoxal Schiff base complexes [Cu(L(1)/L(2))(B)]ClO4 (1-4), where HL(1) is 4-(((2-(1H-imidazol-4-yl)ethyl)imino)methyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol (in 1 and 2), HL(2) is 2-(((2-(1H-imidazol-4-yl)ethyl)imino)methyl)phenol (in 3, 4), B is 11-(9-acridinyl)dipyrido[3,2-a:2',3'-c]phenazine (acdppz in 1 and 3), dipyrido[3,2-a:2',3'-c]phenazine (in 2) and 1,10-phenanthroline (in 4), were synthesized, characterized and their photocytotoxicity in visible light, intracellular localization, cellular uptake and DNA photocleavage activity were studied...
October 21, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27228756/-study-of-reaction-dynamics-between-bovine-serum-albumin-and-folic-acid-by-stopped-flow-fluorescence
#9
San-xian Ye, Yun-jing Luo, Shu-liang Qiao, Li Li, Cai-hong Liu, Jian-long Shi, Xue-jing An
As a kind of coenzyme of one-carbon enzymes in vivo, folic acid belongs to B vitamins, which can interact with other vitamins and has great significance for converting among amino acids, dividing growth of cells and protein synthesis reactions. Half-life, concentration and reaction rate constant of drugs are important parameters in pharmacokinetic study. In this paper, by utilizing fluorescence spectrophotometer and stopped-flow spectrum analyzer, reaction kinetic parameters between bovine serum albumin(BSA) and folic acid in a bionic system have been investigated, which provide references for parameters of drug metabolism related to folic acid...
January 2016: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
https://www.readbyqxmd.com/read/27145071/2-3-methoxyphenyl-quinazoline-derivatives-a-new-class-of-direct-constitutive-androstane-receptor-car-agonists
#10
Tomas Smutny, Alice Nova, Marcela Drechslerová, Alejandro Carazo, Lucie Hyrsova, Zuzana Rania Hrušková, Jiří Kuneš, Milan Pour, Marcel Špulák, Petr Pavek
Constitutive androstane receptor (CAR) is a key regulator of xenobiotic and endobiotic metabolism. Together with pregnane X (PXR) and aryl hydrocarbon (AHR) receptors, it is referred to as "xenobiotic receptor". The unique properties of human CAR, such as its high constitutive activity, both direct (ligand-binding domain-dependent) and indirect activation have hindered the discovery of direct selective human CAR ligands. Herein, we report a novel class of direct human CAR agonists in a group of 2-(3-methoxyphenyl)quinazoline derivatives...
May 26, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27142831/evaluation-and-physiological-correlation-of-plasma-proteomic-fingerprints-for-deltamethrin-induced-hepatotoxicity-in-wistar-rats
#11
Deepika Arora, Mohammed Haris Siddiqui, Pradeep Kumar Sharma, Sheelendra Pratap Singh, Anurag Tripathi, Payal Mandal, Uma Shankar Singh, Pradhyumna Kumar Singh, Yogeshwer Shukla
AIMS: Uprising reports towards deltamethrin (DLM)-induced toxicity in non-target species including mammals have raised a worldwide concern. Moreover, in the absence of any identified marker, the prediction of DLM elicited early toxic manifestations in non-targets remains elusive. MAIN METHODS: Comprehensive approach of proteome profiling along with conventional toxico-physiological correlation analysis was performed to classify novel protein based markers in the plasma of DLM exposed Wistar rats...
September 1, 2016: Life Sciences
https://www.readbyqxmd.com/read/26995293/prevalence-of-hypercalcemia-related-to-hypervitaminosis-d-in-clinical-practice
#12
C Pérez-Barrios, E Hernández-Álvarez, I Blanco-Navarro, B Pérez-Sacristán, F Granado-Lorencio
BACKGROUND & AIMS: Recent interest in vitamin D has led to a substantial increase in the use of vitamin D supplements. Vitamin D intoxication may be a concern as hypervitaminosis D can result in irreversible calcification of soft tissues so that it is important to detect early markers of vitamin D intoxication. Our aim was to assess the simultaneous presence of biochemical markers of vitamin D toxicity (i.e. hypervitaminosis D, hypercalcemia) and determine the concentrations of 25-OH-vitamin D at which the risk of hypercalcemia, and thus toxicity, might begin...
March 8, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/26987988/a-rankl-wrinkle-denosumab-induced-hypocalcemia
#13
Larissa K Laskowski, David S Goldfarb, Mary Ann Howland, Kelly Kavcsak, Danny M Lugassy, Silas W Smith
The human monoclonal antibody denosumab inhibits osteoclast-mediated bone resorption by binding to receptor activator of nuclear factor κB ligand (RANKL), which is upregulated by tumor cells. Denosumab is indicated to prevent skeletal-related events (SREs) from osteoporosis and metastatic bone disease. We report a case of denosumab-induced hypocalcemia to highlight potential toxicity and treatment considerations. A 66-year-old man with prostate cancer, small cell lung cancer, and bone metastases presented with fatigue, weakness, and muscle spasm...
September 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/26711469/reasons-for-refusal-of-newborn-vitamin-k-prophylaxis-implications-for-management-and-education
#14
Harvey James Hamrick, Elizabeth Kaye Gable, Emily Hruska Freeman, Laurie Louise Dunn, Sarah Pritchett Zimmerman, Molly Moriarty Rusin, Olivia Reid Linthavong, Mary Ellen Wright, Leslie Ann Moss, Asheley Cockrell Skinner
OBJECTIVE: The American Academy of Pediatrics recommends intramuscular (IM) vitamin K prophylaxis for all newborns to prevent vitamin K deficiency bleeding. Given the serious implications of late-onset vitamin K deficiency bleeding, our objective was to examine factors influencing parents' decisions to refuse IM vitamin K prophylaxis. METHODS: Parents intending to refuse IM vitamin K prophylaxis at delivery were recruited from 5 community hospitals, 1 academic medical center, and 2 birthing centers in a single Southeastern state...
January 2016: Hospital Pediatrics
https://www.readbyqxmd.com/read/26643421/-vitamin-e-prevents-the-toxic-effect-of-benzo-a-pryene-on-reproductive-system-in-male-sd-rats
#15
Wei Li, Ting Dong, Kai Yang, Mengyun Wu, Baijie Tu
OBJECTIVE: To investigate the protective effects and the potential mechanisms of vitamin E (VE) on benzo(a)pryene (B[a]P)-induced toxicity in the reproductive system of male rats. 
 METHODS: A total of 60 male Sprague Dawley (SD) rats, weighted 70-90 g, were randomly assigned to 6 groups: a control group, a vehicle group, a B[a]P group (5 mg/kg), a VE (10 mg/kg)+ B[a]P (5 mg/kg) group, a VE (50 mg/kg) + B[a]P (5 mg/kg) group and a VE (100 mg/kg)+B[a]P (5 mg/kg) group (n=10 per group)...
November 2015: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/26231422/lycopene-attenuates-dichlorvos-induced-oxidative-damage-and-hepatotoxicity-in-rats
#16
Am Abu El-Saad, M M Ibrahim, A A Hazani, G A El-Gaaly
Because of the widespread use of dichlorvos (DDVP) for domestic applications, evaluation of their toxic effects is of major concern to public health. Lycopene may lower oxidative stress by a mechanism that is not fully elucidated. The present study was undertaken to evaluate the protective efficacy of lycopene in terms of normalization of altered biochemical parameters following DDVP treatment in rats. Animals were divided into four groups. The first group was used as control, while groups 2, 3, and 4 were orally treated with lycopene (10 mg kg(-1) body weight (b...
June 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/25850544/arsenic-induced-antioxidant-depletion-oxidative-dna-breakage-and-tissue-damages-are-prevented-by-the-combined-action-of-folate-and-vitamin-b12
#17
Nirmallya Acharyya, Bimal Deb, Sandip Chattopadhyay, Smarajit Maiti
Arsenic is a grade I human carcinogen. It acts by disrupting one-carbon (1C) metabolism and cellular methyl (-CH3) pool. The -CH3 group helps in arsenic disposition and detoxification of the biological systems. Vitamin B12 and folate, the key promoters of 1C metabolism were tested recently (daily 0.07 and 4.0 μg, respectively/100 g b.w. of rat for 28 days) to evaluate their combined efficacy in the protection from mutagenic DNA-breakage and tissue damages. The selected tissues like intestine (first-pass site), liver (major xenobiotic metabolizer) and lung (major arsenic accumulator) were collected from arsenic-ingested (0...
November 2015: Biological Trace Element Research
https://www.readbyqxmd.com/read/25753886/amelioration-of-cardiotoxic-impacts-of-diclofenac-sodium-by-vitamin-b-complex
#18
N A Abdulmajeed, H S Alnahdi, N O Ayas, A M Mohamed
OBJECTIVE: The safety of Non-steroidal anti-inflammatory drugs (NSAIDs) use in clinical practice has been questioned. Clinical studies indicate that these drugs cause adverse cardiovascular effects. The aim of this study was to investigate the protective role of vitamin B complex against the cardiotoxic potency of diclofenac sodium induced cardiac damage. MATERIALS AND METHODS: Diclofenac sodium was administered intraperitoneally to rats at either 1.5 mg or 3 mg/kg body weight for 14 consecutive days...
February 2015: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/25610950/calcitriol-exerts-anti-inflammatory-effects-in-keratinocytes-treated-with-autoantibodies-from-a-patient-with-bullous-pemphigoid
#19
S Tukaj, D Grüner, C Tukaj, D Zillikens, M Kasperkiewicz
BACKGROUND: The hormonally active vitamin D metabolite calcitriol and its analogues exert potent effects on cellular differentiation and regulation of immune responses. Although topical vitamin D analogues are widely used for treatment of psoriasis and vitamin D has been increasingly implicated in prevention and protection from several autoimmune diseases, experimental and clinical data in autoimmune bullous diseases are generally lacking. OBJECTIVE: Here, we investigated the effects of calcitriol on keratinocytes treated by bullous pemphigoid (BP) autoantibodies...
February 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/25553694/prophylactic-role-of-b-vitamins-against-bulk-and-zinc-oxide-nano-particles-toxicity-induced-oxidative-dna-damage-and-apoptosis-in-rat-livers
#20
Jehad Mustafa Yousef, Azza Mostafa Mohamed
The aim of this work is to explore the protective of B vitamins (B(3), B(6) and B(12)) against the hepatotoxic potency of either bulk zinc oxide (ZnO-bulk) or its nanoparticles (ZnO-NPs)-induced liver damage in rats. ZnO- bulk or its NPs were administered orally (500 mg/kg b.w.) for 10 successive days. The results revealed that oral co-administration of combination of B vitamins (250 mg B(3), 60 mg B(6) and 0.6 mg B(12)/Kg body weight) daily for 3 weeks to rats intoxicated by either ZnO- bulk or its NPs markedly ameliorated increases in serum of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehdrogenase (LDH)...
January 2015: Pakistan Journal of Pharmaceutical Sciences
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