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https://www.readbyqxmd.com/read/27818348/evaluation-of-the-tobacco-heating-system-2-2-part-6-90-day-oecd-413-rat-inhalation-study-with-systems-toxicology-endpoints-demonstrates-reduced-exposure-effects-of-a-mentholated-version-compared-with-mentholated-and-non-mentholated-cigarette-smoke
#1
Alberto Oviedo, Stefan Lebrun, Ulrike Kogel, Jenny Ho, Wei Teck Tan, Bjoern Titz, Patrice Leroy, Gregory Vuillaume, Monali Bera, Florian Martin, Gregory Rodrigo, Marco Esposito, Ruth Dempsey, Nikolai V Ivanov, Julia Hoeng, Manuel C Peitsch, Patrick Vanscheeuwijck
The toxicity of a mentholated version of the Tobacco Heating System (THS2.2M), a candidate modified risk tobacco product (MRTP), was characterized in a 90-day OECD inhalation study. Differential gene and protein expression analysis of nasal epithelium and lung tissue was also performed to record exposure effects at the molecular level. Rats were exposed to filtered air (sham), to THS2.2M (at 15, 23 and 50 μg nicotine/l), to two mentholated reference cigarettes (MRC) (at 23 μg nicotine/l), or to the 3R4F reference cigarette (at 23 μg nicotine/l)...
November 3, 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27789304/long-term-follow-up-of-median-raphe-cysts-and-parameatal-urethral-cysts-in-male-children
#2
Satoko Matsuyama, Futoshi Matsui, Koji Yazawa, Fumi Matsumoto, Kenji Shimada, Keiko Matsuoka
OBJECTIVES: To clarify the long-term outcome of median raphe cysts (MRCs) and parameatal urethral cysts (PUCs) in males, the clinical, anatomical, and histological findings of these cysts are described, along with treatment and follow-up. METHODS: Forty-six children diagnosed with PUCs and 23 children with MRCs at our institute during the past 14 years were retrospectively reviewed. The indications for surgery were symptoms or family preference. Telephone interviews of the parents or patients were conducted to ascertain the current condition of the cyst at a median age of 12...
October 24, 2016: Urology
https://www.readbyqxmd.com/read/27695518/transgenerational-effects-persist-down-the-maternal-line-in-marine-sticklebacks-gene-expression-matches-physiology-in-a-warming-ocean
#3
Lisa N S Shama, Felix C Mark, Anneli Strobel, Ana Lokmer, Uwe John, K Mathias Wegner
Transgenerational effects can buffer populations against environmental change, yet little is known about underlying mechanisms, their persistence or the influence of environmental cue timing. We investigated mitochondrial respiratory capacity (MRC) and gene expression of marine sticklebacks that experienced acute or developmental acclimation to simulated ocean warming (21°C) across three generations. Previous work showed that acute acclimation of grandmothers to 21°C led to lower (optimized) offspring MRCs...
October 2016: Evolutionary Applications
https://www.readbyqxmd.com/read/27604178/collagenvi-cre-mice-a-new-tool-to-target-stromal-cells-in-secondary-lymphoid-organs
#4
Alejandro Prados, George Kollias, Vasiliki Koliaraki
Stromal cells in secondary lymphoid organs (SLOs) are non-hematopoietic cells involved in the regulation of adaptive immune responses. Three major stromal populations have been identified in adult SLOs: fibroblastic reticular cells (FRCs), follicular dendritic cells (FDCs) and marginal reticular cells (MRCs). The properties of these individual populations are not clearly defined, mainly due to the lack of appropriate genetic tools, especially for MRCs. Here, we analyzed stromal cell targeting in SLOs from a transgenic mouse strain that expresses Cre recombinase under the CollagenVI promoter, using lineage tracing approaches...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27455668/magnetically-recyclable-fe3o4-his-cu-nanocatalyst-for-degradation-of-azo-dyes
#5
U Kurtan, Md Amir, A Baykal, H Sözeri, M S Toprak
Fe3O4@His@Cu magnetic recyclable nanocatalyst (MRCs) was synthesized by reflux method using L-histidine as linker. The composition, structure and magnetic property of the product were characterized by X-ray powder diffraction (XRD), Scanning electron microscopy (SEM), Fourier Transform infrared spectroscopy (FT-IR) and vibrating sample magnetometry (VSM). Powder XRD, FT-IR and EDAX results confirmed that the as-synthesized products has Fe3O4 with spinel structure and Cu nanoparticles with moderate crystallinity without any other impurities...
March 2016: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/27437298/penile-epidermal-cyst-a-case-report
#6
Veerapandian Kumaraguru, Ravi Prabhu, Narayanasamy Subbaraju Kannan
Epidermal cysts also known as epidermoid cysts, is one of the common benign tumours presenting anywhere in the body. However, epidermal cyst in the penis is very rare. This condition in children is usually congenital due to abnormal embryologic closure of the median raphe; hence, it is termed as median raphe cysts (MRCs). Penile epidermal cysts may occur in adults following trauma or surgery due to epidermal elements being trapped within closed space. During wound healing, trapped squamous epithelium, undergoing keratinisation leads to cyst formation...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27376182/outcomes-of-immediate-allograft-reconstruction-of-long-span-defects-of-the-inferior-alveolar-nerve
#7
David Salomon, Michael Miloro, Antonia Kolokythas
PURPOSE: Contemporary management of ablative jaw defects includes not only hard and soft tissue reconstruction, but also restoration of neurosensory function. The goal of this study was to determine the outcomes of immediate reconstruction of long-span defects (≥50 mm) of the inferior alveolar nerve (IAN) after ablative mandibular resection using allogeneic nerve grafts. MATERIALS AND METHODS: A retrospective cohort study of patients who underwent immediate reconstruction of IAN gaps of at least 50 mm with allogeneic nerve graft (AxoGen Avance, Alachua, FL) at a single academic medical center by a single surgeon (M...
December 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27307370/a-compelling-new-diagnostic-option-for-identification-of-orthopaedic-infections-commentary-on-an-article-by-m-c-wyatt-bsc-hons-mbchb-mrcs-ed-fracs-tr-orth-et-al-the-alpha-defensin-immunoassay-and-leukocyte-esterase-colorimetric-strip-test-for-the-diagnosis
#8
https://www.readbyqxmd.com/read/27271330/numerical-research-on-the-anisotropic-transport-of-thermal-neutron-in-heterogeneous-porous-media-with-micron-x-ray-computed-tomography
#9
Yong Wang, Wenzheng Yue, Mo Zhang
The anisotropic transport of thermal neutron in heterogeneous porous media is of great research interests in many fields. In this paper, it is the first time that a new model based on micron X-ray computed tomography (CT) has been proposed to simultaneously consider both the separation of matrix and pore and the distribution of mineral components. We apply the Monte Carlo method to simulate thermal neutrons transporting through the model along different directions, and meanwhile detect those unreacted thermal neutrons by an array detector on the other side of the model...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27098331/metal-on-metal-testing-to-salvage-a-device-disaster-commentary-on-an-article-by-gulraj-s-matharu-bsc-hons-mbchb-mrcs-mres-et-al-the-effectiveness-of-blood-metal-ions-in-identifying-patients-with-unilateral-birmingham-hip-resurfacing-and-corail-pinnacle-metal
#10
COMMENT
https://www.readbyqxmd.com/read/27062361/mr-norman-alan-green-mb-bs-1950-ms-1964-mrcs-lrcp-1950-frcs-1954-frcsed-1990-2nd-july-1927-4th-may-2015-an-appreciation-by-stuart-w-mcdonald
#11
https://www.readbyqxmd.com/read/26780219/the-potential-role-of-polyamines-in-gill-epithelial-remodeling-during-extreme-hypoosmotic-challenges-in-the-gulf-killifish-fundulus-grandis
#12
Ying Guan, Guo-Xia Zhang, Shujun Zhang, Beau Domangue, Fernando Galvez
Polyamines are a family of low molecular weight organic cations produced in part by the coordinated actions of arginase II (Arg II) and ornithine decarboxylase (Odc). Although gill polyamine homeostasis is affected by acute transfer to fresh water, little is known of its function in fish osmoregulation. The current study investigated the role of polyamines in the compensatory response of hypoosmotic challenge in the euryhaline fish, Fundulus grandis. Adult F. grandis were acclimated to 5 ppt water, transferred abruptly to 5, 2, 1, 0...
April 2016: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/26691432/william-cooke-md-mrcs-1785-1873-general-practitioner-founder-of-the-hunterian-society-and-deacon-of-the-congregational-church
#13
Peter Selley
Farmer's son William Cooke completed his medical training at Barts before embarking on a 60-year career as a general practitioner in and around London. In 1819, he was a co-founder, and for 20 years secretary, of the Hunterian Society which continues to provide education to its members. He was the author of several books where his views on the importance of post-mortem examinations and the interrelationships of body and mind in disease were discussed. He was a prominent non-conformist and became a deacon in the Congregational Church...
December 21, 2015: Journal of Medical Biography
https://www.readbyqxmd.com/read/26678671/transcriptomic-analysis-reveals-specific-osmoregulatory-adaptive-responses-in-gill-mitochondria-rich-cells-and-pavement-cells-of-the-japanese-eel
#14
Keng Po Lai, Jing-Woei Li, Je Gu, Ting-Fung Chan, William Ka Fai Tse, Chris Kong Chu Wong
BACKGROUND: Homeostasis of ions and water is important for the maintenance of cellular functions. The regulation of the homeostasis is particularly important in euryhaline fish that migrate between freshwater (FW) and seawater (SW) environments. The fish gill, the major tissue that forms an interface separating the extracellular fluids and external water environment, has an effective transport system to maintain and regulate a constant body osmolality. In fish gills, the two major epithelial cells, pavement cells (PVCs) and mitochondria-rich cells (MRCs), are known to play key and complementary roles in ion transport at the interface...
2015: BMC Genomics
https://www.readbyqxmd.com/read/26614501/adaptive-alterations-on-gill-na%C3%A2-%C2%BA-k%C3%A2-%C2%BA-atpase-activity-and-mitochondrion-rich-cells-of-juvenile-acipenser-sinensis-acclimated-to-brackish-water
#15
Feng Zhao, Beibei Wu, Gang Yang, Tao Zhang, Ping Zhuang
Understanding the physiological changes and osmoregulatory strategy is critical for anadromous species to adapt to large changes between freshwater and marine environments. In this study, juvenile Chinese sturgeon (Acipenser sinensis) were acclimated for 2 months to freshwater (FW, c. 0‰) and brackish water (BW, 15‰). Blood was assessed for changes in osmolality and ions. Gill tissue was assayed for Na(+), K(+)-ATPase (NKA) activity and immunohistochemical analysis on mitochondria-rich cells (MRCs). Serum osmolality and ions concentrations (Na(+), Cl(-) and K(+)) examined, except K(+), increased significantly in those specimens adapted to BW...
April 2016: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/26449254/genome-wide-architecture-of-disease-resistance-genes-in-lettuce
#16
Marilena Christopoulou, Sebastian Reyes-Chin Wo, Alex Kozik, Leah K McHale, Maria-Jose Truco, Tadeusz Wroblewski, Richard W Michelmore
Genome-wide motif searches identified 1134 genes in the lettuce reference genome of cv. Salinas that are potentially involved in pathogen recognition, of which 385 were predicted to encode nucleotide binding-leucine rich repeat receptor (NLR) proteins. Using a maximum-likelihood approach, we grouped the NLRs into 25 multigene families and 17 singletons. Forty-one percent of these NLR-encoding genes belong to three families, the largest being RGC16 with 62 genes in cv. Salinas. The majority of NLR-encoding genes are located in five major resistance clusters (MRCs) on chromosomes 1, 2, 3, 4, and 8 and cosegregate with multiple disease resistance phenotypes...
December 2015: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/26401230/preliminary-report-of-instrumentation-in-tuberculous-lumbosacral-spine
#17
Mrcs T Zin-Naing
The aims of spinal tuberculosis treatment are to eradicate the disease, to prevent the development of paraplegia and kyphotic deformity, to manage the existing deformity and neurological deficit, to allow early ambulation and to return the patient back to daily life. Methods for the treatment of tuberculosis of vertebra are still controversial. Conservative treatment includes medical therapy as well as external supports and surgery is indicated for deformity of spine, severe pain, or neurological compromise conditions...
November 2014: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/26331145/frequency-of-maxillary-sinus-mucous-retention-cysts-in-a-central-brazilian-population
#18
Evanice Menezes Marçal Vieira, Sylvania de Morais, Carlo Ralph de Musis, Álvaro Henrique Borges, Vinícius Canavarros Palma, Laiane da Silva Basilio, Orlando Aguirre Guedes
STATEMENT OF THE PROBLEM: Mucous retention cysts (MRCs) of the maxillary sinus are lesions with undefined pathogenesis. In recent researches, geographical and climatic aspects have been related as risk factors. PURPOSE: The purpose of this study was to determine the frequency of MRCs of the maxillary sinus using panoramic radiographs. MATERIALS AND METHOD: A total of 631 panoramic radiographs were selected from a secondary database from a private radiology clinic and analyzed by two specialists in dental radiology according to gender, age, month, relative air humidity, and mean temperature...
September 2015: Journal of Dentistry
https://www.readbyqxmd.com/read/26254909/ethics-and-the-facial-plastic-surgeon
#19
REVIEW
Neeraj Sethi
The facial plastic surgeon potentially has a conflict of interest when confronted with the patients requesting surgery, due to the personal gain attainable by agreeing to perform surgery. The aim of this review is to discuss the potential harm the surgeon can inflict by carrying out facial plastic surgery, beyond the standard surgical complications of infection or bleeding. It will discuss the desire for self-improvement and perfection and increase in the prevalence facial plastic surgery. We address the principles of informed consent, beneficence and non-maleficence, as well as justice and equality and how the clinician who undertakes facial plastic surgery is at risk of breaching these principles without due care and diligence...
September 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/26115689/gill-paracellular-permeability-and-the-osmorespiratory-compromise-during-exercise-in-the-hypoxia-tolerant-amazonian-oscar-astronotus-ocellatus
#20
Lisa M Robertson, Daiani Kochhann, Adalto Bianchini, Victoria Matey, Vera F Almeida-Val, Adalberto Luis Val, Chris M Wood
In the traditional osmorespiratory compromise, fish increase their effective gill permeability to O2 during exercise or hypoxia, and in consequence suffer unfavorable ionic and osmotic fluxes. However oscars, which live in the frequently hypoxic ion-poor waters of the Amazon, actually decrease ionic fluxes across the gills during acute hypoxia without changing gill paracellular permeability, and exhibit rapid paving over of the mitochondrial-rich cells (MRCs). But what happens during prolonged exercise? Gill paracellular permeability, ionic fluxes, and gill morphology were examined in juvenile oscars at rest and during aerobic swimming...
October 2015: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
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