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https://www.readbyqxmd.com/read/29772474/mitochondria-rich-cells-adjustments-and-ionic-balance-in-the-neotropical-fish-prochilodus-lineatus-exposed-to-titanium-dioxide-nanoparticles
#1
Talita L L Carmo, Vinícius C Azevedo, Priscila R Siqueira, Tiago D Galvão, Fabrício A Santos, Cláudia B R Martinez, Carlos R Appoloni, Marisa N Fernandes
Manufactured titanium dioxide nanoparticles (TiO2 -NP) have been intensely applied in numerous industrial products and may be a risk for aquatic systems as they are not completely removed from domestic and industrial wastes after water treatment. This study evaluated the osmo- and ionic balance, Na+ /K+ -ATPase, H+ -ATPase and carbonic anhydrase activities and the mitochondria-rich cells (MRC) in the gills and kidney of the Neotropical fish Prochilodus lineatus after 2 (acute) and 14 (subchronic) days of exposure to nominal 0, 1, 5, 10 and 50 mg L-1 TiO2 -NP...
May 9, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29770572/intralesional-steroid-injection-as-an-alternative-treatment-for-57-patients-of-vocal-fold-mucus-retention-cysts
#2
Po-Hsuan Wu, Po-Wen Cheng, Feng-Chuan Lin, Chi-Te Wang
This study intends to validate the effectiveness of vocal fold steroid injection (VFSI) for mucus retention cysts (MRCs) by comparing the treatment outcome with a control group and investigate the risk factors for recurrence. This study recruited 57 patients with vocal fold MRCs treated with in-office VFSI between January 2014 and December 2016. Another 24 patients with MRCs receiving only conservative treatment during the same study period were included as the control group. Treatment outcomes comparison of the 22 age- and sex- matched patients between the VFSI and control groups demonstrated significantly better improvements among the patients receiving VFSI in maximal phonation, perceptual voice quality, and 10-item voice handicap index...
May 16, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29739636/factors-predicting-success-in-the-intercollegiate-membership-of-the-royal-college-of-surgeons-mrcs-examination-a-summary-for-omfs
#3
EDITORIAL
D S G Scrimgeour, J Cleland, A J Lee, P A Brennan
The Intercollegiate Membership of the Royal College of Surgeons (MRCS, parts A and B) is a mandatory examination for entry into higher surgical training in the UK. We investigated which factors predict success in both the written (Part A) and clinical (Part B) parts of the examination, and provide a summary for oral and maxillofacial surgeons (OMFS). All UK graduates who attempted both parts between 2007 and 2016 were included. There was a positive correlation between the scores in parts A and B (r=0.41, p<0...
May 5, 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29686051/cutting-edge-identification-of-marginal-reticular-cells-as-phagocytes-of-apoptotic-b-cells-in-germinal-centers
#4
Kazuki Sato, Shin-Ichiro Honda, Akira Shibuya, Kazuko Shibuya
Germinal centers (GCs) in secondary lymphoid organs generate large numbers of apoptotic B cells that must be eliminated by phagocytes to prevent the development of autoimmune diseases. Although tingible body macrophages engulf apoptotic GC B cells, whether stromal cells are also involved in this process is unclear. In this study, we identified marginal reticular cells (MRCs) as novel nonprofessional phagocytes for the clearance of apoptotic GC B cells in the spleen. We used CD19eGFP (CD19cre Z/EG) mice, which express enhanced GFP (eGFP) under the control of CD19cre expression, to track B cells in the GCs after immunization with NP-chicken γ globulin plus aluminum salt...
April 23, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29607719/predictors-of-success-in-the-intercollegiate-membership-of-the-royal-college-of-surgeons-mrcs-examination
#5
Dsg Scrimgeour, J Cleland, A J Lee, P A Brennan
Introduction The Intercollegiate Membership of the Royal College of Surgeons (MRCS, Parts A and B) is designed to safeguard patients and ensure high standards for trainees wishing to pursue a surgical career. We investigated which factors predict Part A and B success. Methods UK graduates who had attempted both parts of MRCS from September 2007 to February 2016 were included. Pearson correlation coefficients were used to examine the linear relationship between each part of MRCS and logistic regression analysis to identify potential independent predictors of MRCS pass/fail outcome...
April 1, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29509626/ever-safer-total-hip-replacements-commentary-on-an-article-by-thomas-partridge-mbbs-mrcs-et-al-ten-year-trends-in-medical-complications-following-540-623-primary-total-hip-replacements-from-a-national-database
#6
https://www.readbyqxmd.com/read/29480729/development-of-health-research-structures-over-the-last-25-years-main-achievements-and-challenges
#7
Shirin Djalalinia, Mohammad Bagher Talei, Farzaneh Barhemmat, Fatemeh Mohammadali Khalaj, Hamideh Heydari, Hossein Zokaei, Shahin Akhondzadeh, Asghar Ebadifar
BACKGROUND: In 1990, one of the most important strategies of supporting and managing reproductive research focused on development of research structures. This targeted vision, at the first step, mainly followed through creating research units. The present paper aims to explore the policies and strategies of medical research centers (MRCs)development, and its achievements and challenges over the last 25 years. METHODS: Based on expected outcomes of better directions of research activities aligned with the priorities and policies of research, the Deputy of Research and Technology of Ministry of Health and Medical Education (MOHME), initiated the set up and development of research units...
November 1, 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29450611/high-spatial-resolution-navigated-3d-t1-weighted-hepatobiliary-mr-cholangiography-using-gd-eob-dtpa-for-evaluation-of-biliary-anatomy-in-living-liver-donors
#8
Jei Hee Lee, Bohyun Kim, Hye Jin Kim, Bong-Wan Kim, Hee-Jung Wang, Jai Keun Kim
PURPOSE: To determine the feasibility of high-resolution navigated three-dimensional (3D) T1-weighted hepatobiliary MR cholangiography (Nav T1 MRC) using Gd-EOB-DTPA for biliary visualization in living liver donors and to assess added value of 3D T1-weighted hepatobiliary MRCs in improving the confidence and diagnostic accuracy of biliary anatomy in complementary to T2-weighted MRCs. METHODS: Twenty-nine right liver donors underwent 3D T2 MRC, 2D T2 MRC, breath-hold T1-weighted hepatobiliary MRC (BH T1 MRC), and Nav T1 MRC...
February 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29148629/carbohydrate-mouth-rinse-improves-cycling-performance-carried-out-until-the-volitional-exhaustion
#9
Bruno Bavaresco Gambassi, Ylana Gomes de Santana Barros Leal, Edson R Pinheiro Dos Anjos, Bruna A Antonelli, Daniela C Gomes Gonçalves E Silva, Iracema H Pires de Mélo Montenegro, Rita di Cássia de Oliveira Angelo, Isis S Correia Moura, Paulo A Schwingel
BACKGROUND: Carbohydrates (CHO) are among the most investigated nutritional ergogenic aids, and may be consumed in different forms, e.g., mouth rinse with carbohydrate solution (MRCS). In this sense, the aim of this study was to evaluate the impact of MRCS on the performance of physically active individuals undergoing a physical exercise session carried out until the volitional exhaustion. METHODS: This is a counter-balanced randomized study, with a double-blind design...
November 17, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29102295/which-factors-predict-success-in-the-mandatory-uk-postgraduate-surgical-exam-the-intercollegiate-membership-of-the-royal-college-of-surgeons-mrcs
#10
D S G Scrimgeour, J Cleland, A J Lee, P A Brennan
BACKGROUND: The Membership of the Royal College of Surgeons examination (MRCS, Parts A and B) is one of the largest postgraduate surgical exams in the world, but little is known about the factors that affect candidate performance. We describe the relationship between both parts of MRCS and several independent predictors of MRCS success. METHODS: Pearson correlation coefficients were used to examine the linear relationship between MRCS Part A and B and logistic regression analysis to identify potential independent predictors of MRCS success...
October 25, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29056479/effect-of-combined-stress-salinity-and-temperature-in-european-sea-bass-dicentrarchus-labrax-osmoregulatory-processes
#11
Waliullah Masroor, Emilie Farcy, Romain Gros, Catherine Lorin-Nebel
European sea bass Dicentrarchus labrax undertake seasonal migrations to estuaries and lagoons that are characterized by fluctuations in environmental conditions. Their ability to cope with these unstable habitats is undeniable, but it is still not clear how and to what extent salinity acclimation mechanisms are affected at temperatures higher than in the sea. In this study, juvenile sea bass were pre-acclimated to seawater (SW) at 18°C (temperate) or 24°C (warm) for 2weeks and then transferred to fresh water (FW) or SW at the respective temperature...
January 2018: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/29044658/gills-of-the-medaka-oryzias-latipes-a-scanning-electron-microscopy-study
#12
Isabelle Leguen
The general morphology and surface ultrastructure of the gills of adult and larvae medaka (Oryzias latipes) were studied in freshwater and seawater using scanning electron microscopy. The gills of all examined fish were structurally similar to those of other teleosts and consisted of four pairs of arches supporting (i) filaments bearing lamellae and (ii) rakers containing taste buds. Three cell types, specifically pavement cells, mitochondria-rich cells (MRCs), and mucous cells, constituted the surface layer of the gill epithelium...
January 2018: Journal of Morphology
https://www.readbyqxmd.com/read/28994389/molecular-architecture-underlying-fluid-absorption-by-the-developing-inner-ear
#13
Keiji Honda, Sung Huhn Kim, Michael C Kelly, Joseph C Burns, Laura Constance, Xiangming Li, Fei Zhou, Michael Hoa, Matthew W Kelley, Philine Wangemann, Robert J Morell, Andrew J Griffith
Mutations of SLC26A4 are a common cause of hearing loss associated with enlargement of the endolymphatic sac (EES). Slc26a4 expression in the developing mouse endolymphatic sac is required for acquisition of normal inner ear structure and function. Here, we show that the mouse endolymphatic sac absorbs fluid in an SLC26A4-dependent fashion. Fluid absorption was sensitive to ouabain and gadolinium but insensitive to benzamil, bafilomycin and S3226. Single-cell RNA-seq analysis of pre- and postnatal endolymphatic sacs demonstrates two types of differentiated cells...
October 10, 2017: ELife
https://www.readbyqxmd.com/read/28953520/an-evaluation-of-different-bridging-techniques-for-short-nerve-gaps
#14
Imran Ahmad, Mohd Altaf Mir, Arshad Hafeez Khan
BACKGROUND: In this study, we investigated sensory and motor outcomes for different bridging techniques for short nerve gaps. MATERIAL AND METHODS: This study was conducted in the Postdoctoral Department of Burns, Plastic, and Reconstructive Surgery of our institution from August 2014 to May 2017. All patients with posttraumatic short nerve gaps of 3 cm or less of median, ulnar, and/or both in forearm and wrists were included in the study. Patients with known causes of neuropathies were excluded...
November 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28926394/armd-and-presumed-dangerous-commentary-on-an-article-by-gulraj-s-matharu-bsc-hons-mrcs-mres-et-al-blood-metal-ion-thresholds-to-identify-patients-with-metal-on-metal-hip-implants-at-risk-of-adverse-reactions-to-metal-debris-an-external-multicenter-validation
#15
COMMENT
https://www.readbyqxmd.com/read/28920140/frequency-location-and-association-with-dental-pathology-of-mucous-retention-cysts-in-the-maxillary-sinus-a-radiographic-study-using-cone-beam-computed-tomography-cbct
#16
Andy Wai Kan Yeung, Ray Tanaka, Pek-Lan Khong, Thomas von Arx, Michael M Bornstein
OBJECTIVES: The purpose of the present study was to evaluate the frequency, locations, and dimensions of mucous retention cysts of the maxillary sinus and analyze potential associated dental pathology. MATERIALS AND METHODS: A total of 156 cone beam computed tomography (CBCT) scans were included in the analysis, resulting in an evaluation of 310 maxillary sinuses. The presence of mucous retention cysts (MRC) manifesting as dome-shaped radiopacities in the sinus was diagnosed...
September 17, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28841698/long-term-follow-up-of-mri-changes-in-thigh-muscles-of-patients-with-facioscapulohumeral-dystrophy-a-quantitative-study
#17
Farzad Fatehi, Emmanuelle Salort-Campana, Arnaud Le Troter, Emilie Lareau-Trudel, Mark Bydder, Alexandre Fouré, Maxime Guye, David Bendahan, Shahram Attarian
Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common hereditary muscular disorders. Currently FSHD has no known effective treatment and detailed data on the natural history are lacking. Determination of the efficacy of a given therapeutic approach might be difficult in FSHD given the slow and highly variable disease progression. Magnetic resonance imaging (MRI) has been widely used to qualitatively and quantitatively evaluate in vivo the muscle alterations in various neuromuscular disorders...
2017: PloS One
https://www.readbyqxmd.com/read/28830730/identification-and-distribution-of-neuronal-nitric-oxide-synthase-and-neurochemical-markers-in-the-neuroepithelial-cells-of-the-gill-and-the-skin-in-the-giant-mudskipper-periophthalmodon-schlosseri
#18
Giacomo Zaccone, Eugenia Rita Lauriano, Michał Kuciel, Gioele Capillo, Simona Pergolizzi, Alessio Alesci, Atsushi Ishimatsu, Yuen Kwong Ip, Jose M Icardo
Mudskippers are amphibious fishes living in mudflats and mangroves. These fishes hold air in their large buccopharyngeal-opercular cavities where respiratory gas exchange takes place via the gills and higher vascularized epithelium lining the cavities and also the skin epidermis. Although aerial ventilation response to changes in ambient gas concentration has been studied in mudskippers, the localization and distribution of respiratory chemoreceptors, their neurochemical coding and function as well as physiological evidence for the gill or skin as site for O2 and CO2 sensing are currently not known...
December 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/28747514/mechanoresponsive-stem-cells-to-target-cancer-metastases-through-biophysical-cues
#19
Linan Liu, Shirley X Zhang, Wenbin Liao, Henry P Farhoodi, Chi W Wong, Claire C Chen, Aude I Ségaliny, Jenu V Chacko, Lily P Nguyen, Mengrou Lu, George Polovin, Egest J Pone, Timothy L Downing, Devon A Lawson, Michelle A Digman, Weian Zhao
Despite decades of effort, little progress has been made to improve the treatment of cancer metastases. To leverage the central role of the mechanoenvironment in cancer metastasis, we present a mechanoresponsive cell system (MRCS) to selectively identify and treat cancer metastases by targeting the specific biophysical cues in the tumor niche in vivo. Our MRCS uses mechanosensitive promoter-driven mesenchymal stem cell (MSC)-based vectors, which selectively home to and target cancer metastases in response to specific mechanical cues to deliver therapeutics to effectively kill cancer cells, as demonstrated in a metastatic breast cancer mouse model...
July 26, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28711646/rural-rotations-at-core-rarefied-exposure-or-real-experience
#20
Christopher Brown, Tarig Abdelrahman, Neil Patel, Awen Iorwerth, John Pollitt, Mark Holt, Wyn G Lewis
OBJECTIVE: Surgical rotations involving rural General Hospitals (rGH) are frequently associated with recruitment challenges, partly because of adverse perceptions regarding distances from social support networks and training opportunities. The aim of this study was to determine the outcomes of core surgical training rotations involving rGHs when compared with urban hospitals in a single UK Deanery. DESIGN: Online Intercollegiate Surgical Curriculum Programme portfolios from 163 core surgical trainees (CST) were examined related to postlocation, operative experience, workplace-based assessments, and academic achievement...
January 2018: Journal of Surgical Education
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