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https://www.readbyqxmd.com/read/29036204/metabolic-phenotyping-in-the-mouse-model-of-urinary-tract-infection-shows-that-3-hydroxybutyrate-in-plasma-is-associated-with-infection
#1
Pei Han, Yong Huang, Yumin Xie, Wu Yang, Yaoyao Wang, Wenying Xiang, Peter J Hylands, Cristina Legido-Quigley
Urinary tract infection is one of the most common bacterial infections worldwide. Current diagnosis of urinary tract infection chiefly relies on its clinical presentation, urine dipstick tests and urine culture. Small molecules found in bio-fluids related with both infection and recovery would facilitate diagnosis and management of UTI. Mass spectrometry-based fingerprinting of plasma and urine at 3 time points, pre-infection (t = -24h), infection (t = 24h) and post 3-day treatment (t = 112h), were acquired in the following four groups: mice which were healthy, infected but not treated, infected and treated with ciprofloxacin, and infected and treated with Relinqing® granules (n = 6 per group)...
2017: PloS One
https://www.readbyqxmd.com/read/29035286/urocytological-evaluation-of-pemphigus-patients-on-long-term-cyclophosphamide-therapy-a-cross-sectional-study
#2
Sujay Khandpur, Saurabh Singh, Saumyaranjan Mallick, Vinod Kumar Sharma, Venkat Iyer, Amlesh Seth, Mahesh Kumawat
BACKGROUND: Cyclophosphamide therapy is associated with several urological complications including urinary bladder malignancy. Data on urologic complications of chronic cyclophosphamide therapy for dermatologic conditions is not available. OBJECTIVES: To study the urocytological profile of pemphigus patients on long-term cyclophosphamide therapy. MATERIALS AND METHODS: In a cross-sectional study, consecutive patients who had received cyclophosphamide therapy for pemphigus for more than 12 months were included...
November 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29035239/diagnosis-of-trichomoniasis-in-male-patients-on-performing-nested-polymerase-chain-reaction
#3
T Mutlu Yar, Mehmet Karakuş, Seray Töz, Aysun Bay Karabulut, Yusuf Özbel, Metin Atambay
OBJECTIVE: Trichomoniasis is a parasitic infection that occurs with the settlement of Trichomonas vaginalis in female and male urinary and reproductive tracts. This infection is generally asymptomatic in males, and males are thought to be a carrier for the transmission of infection. In this study, our aim was to detect trichomoniasis using nested polymerase chain reaction among males who were referred to a hospital with suspected urinary tract infection. METHODS: Urine samples were collected from 138 male patients between 18 and 50 years of age who were referred with suspected urinary system infection to the Urology Outpatient Clinic at Malatya University Medical Center Malatya between December 2013 and May 2014...
September 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29032949/correction-of-hyperleucinemia-in-msud-patients-on-leucine-free-dietary-therapy
#4
Anna I Scott, Kristina Cusmano-Ozog, Gregory M Enns, Tina M Cowan
PURPOSE: Maple Syrup Urine Disease (MSUD) is a rare disorder of branched-chain amino acid catabolism associated with encephalopathy from accumulation of leucine. Leucine is closely monitored during normal growth and particularly during acute illness. As most hospitals do not have access to rapid plasma amino acid quantification, the initial management is often empirical. A model describing the reduction of plasma leucine in hyperleucinemic patients on leucine-free formula would help to guide management and optimize testing frequency...
October 5, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29032597/more-than-two-years-follow-up-of-infants-with-congenital-cytomegalovirus-infection-in-japan
#5
Shin Koyano, Ichiro Morioka, Akira Oka, Hiroyuki Moriuchi, Kimisato Asano, Yushi Ito, Tetsushi Yoshikawa, Hideto Yamada, Tatsuo Suzutani, Naoki Inoue
BACKGROUND: The aim of the study was to evaluate outcomes of congenital cytomegalovirus (CMV) cases identified by our urine-filter screening assay after follow-up for more than 2 years, and to observe the clinical outcomes after anti-CMV therapies. METHODS: Sixty of the 72 congenital CMV cases were enrolled. Forty-three cases asymptomatic at birth, 7 cases symptomatic at birth but untreated with anti-CMV drugs, and 10 symptomatic cases treated with anti-CMV drugs were clinically observed for more than 2 years...
October 15, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29032522/comparative-characteristic-of-antimicrobial-resistance-in-geriatric-hospital-a-retrospective-cohort-study
#6
G Goltsman, E H Mizrahi, A Leibovitz, G Gal, O Gorelik, E Lubart
BACKGROUND AND AIMS: To examine antimicrobial resistance of commonly isolated pathogens in elderly hospitalized patients. METHODS: Data regarding all clinically significant isolates from blood and urine cultures of patients admitted to a multilevel geriatric hospital during March 2015 to April 2016 were collected. Antimicrobial susceptibility testing was performed according to Clinical and Laboratory Standard Institute guidelines. RESULTS: Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae were the most common isolates, with proportions of extended spectrum beta-lactamase positivity of 60, 40, and 61% respectively...
October 14, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29031313/routes-to-diagnosis-for-men-with-prostate-cancer-men-s-cultural-beliefs-about-how-changes-to-their-bodies-and-symptoms-influence-help-seeking-actions-a-narrative-review-of-the-literature
#7
REVIEW
Michelle King-Okoye, Anne Arber, Sara Faithfull
PURPOSE: To examine the findings of existing studies in relation to men's cultural beliefs about changes to their bodies relevant to prostate cancer and how these affect interpretation of bodily changes and help-seeking actions. METHOD: We undertook a narrative review of studies conducted from 2004 to 2017 in 6 databases that highlighted men's beliefs and help-seeking actions for bodily changes suggestive of prostate cancer. RESULTS: Eighteen (18) studies reflecting men from various ethnicities and nationalities were included...
October 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29031032/the-frequency-and-clinical-implications-of-bacteriuria-in-chronically-paralyzed-dogs
#8
S R Baigi, S Vaden, N J Olby
BACKGROUND: Paralysis is a known risk factor for urinary tract infections (UTI), sepsis, and death in paralyzed people, but there are no data available on diagnostic criteria for UTI versus bacteriuria, their frequency, or clinical implications in chronically paralyzed dogs. HYPOTHESIS/OBJECTIVES: That chronically paralyzed dogs suffer frequent bacteriuria causing reduced duration of survival. We documented the frequency of bacteriuria, associated clinical signs, and survival rate in chronically paralyzed dogs...
October 14, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29030135/staphylococcus-saprophyticus-which-%C3%AE-lactam
#9
Hélène Pailhoriès, Viviane Cassisa, Rachel Chenouard, Marie Kempf, Matthieu Eveillard, Carole Lemarié
OBJECTIVES: Staphylococcus saprophyticus (SS) is resistant to molecules often used in empiric treatment of urinary-tract infections (UTI). The adequacy of antimicrobial treatments prescribed for UTI due to SS is not usually questioned. We described the epidemiology of those infections and assessed the susceptibility of SS to ceftriaxone and amoxicillin-clavulanic acid. METHODS: From November 2014 to July 2016, the methicillin susceptible SS (MSSS) isolated from clinical samples were included...
October 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29029647/renal-manifestations-of-hiv-during-the-antiretroviral-era-in-south-africa-a-systematic-scoping-review
#10
Shirelle Assaram, Nombulelo P Magula, Suman Mewa Kinoo, Tivani P Mashamba-Thompson
BACKGROUND: It is estimated that 650,000 patients may develop human immunodeficiency virus (HIV)-related renal disease in South Africa. South Africa has recently adopted WHO policy, stipulating that all HIV-infected patients have access to antiretroviral treatment (ART) irrespective of CD4 cell count. METHODS: We searched Google Scholar, PubMed, Medline, Cochrane Library, Worldcat.org and EBSCO host databases from July 2015 to December 2015. Eligibility criteria included articles pertaining to renal manifestations of HIV in South Africa from 2004 to 2015 in adult patients (≥ 18 years)...
October 13, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29029307/droplet-digital-pcr-diagnosis-of-human-schistosomiasis-parasite-cell-free-dna-detection-in-diverse-clinical-samples
#11
Kosala G Weerakoon, Catherine A Gordon, Gail M Williams, Pengfei Cai, Geoffrey N Gobert, Remigio M Olveda, Allen G Ross, David U Olveda, Donald P McManus
Background: Schistosomiasis japonica remains a major public health and socio-economic concern in Southeast-Asia. Sensitive and accurate diagnostics can play a pivotal role in achieving disease elimination goals. Methods: We previously reported a novel droplet digital-PCR (ddPCR) assay targeting the mitochondrial gene nad1 to diagnose schistosomiasis japonica. The tool identified both pre-patent and patent infections using Schistosoma japonicum DNA isolated from serum, urine, salivary glands and faeces in a murine model...
September 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29028662/stool-xpert-mtb-rif-and-urine-lipoarabinomannan-lam-for-diagnosing-tuberculosis-in-hospitalized-hiv-infected-children
#12
Sylvia M Lacourse, Patricia B Pavlinac, Lisa M Cranmer, Irene N Njuguna, Cyrus Mugo, John Gatimu, Joshua Stern, Judd L Walson, Elizabeth Maleche-Obimbo, Julius Oyugi, Dalton Wamalwa, Grace John-Stewart
BACKGROUND: Tuberculosis (TB ) causes substantial morbidity and mortality in HIV-infected children. Sample collection and paucibacillary nature of TB in children makes diagnosis challenging. Rapid diagnostic tools using easily obtained specimens are urgently needed. METHODS: Hospitalized, HIV-infected children ≤12 years enrolled in a randomized controlled trial (NCT02063880) comparing urgent to poststabilization ART initiation in Kenya underwent TB evaluation...
October 12, 2017: AIDS
https://www.readbyqxmd.com/read/29028588/formation-of-struvite-urinary-stones-and-approaches-towards-the-inhibition-a-review
#13
REVIEW
Poppy Das, Gaurav Gupta, Vinodhini Velu, Rajendra Awasthi, Kamal Dua, Himaja Malipeddi
BACKGROUND: Struvite is one of the most common urinary/kidney stones, composed of magnesium ammonium phosphate (MgNHPO4·H2O). They are also termed as infection stones as these are associated with urinary tract infections. Numerous studies have been carried out to examine the growth and inhibition of struvite stones. OBJECTIVE: This review summarizes various reports on the factors responsible for inducing struvite stones in the kidney and gives a detailed account of studies on inhibition of growth of struvite crystals...
October 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29027940/zika-virus-persistently-and-productively-infects-primary-adult-sensory-neurons-in-vitro
#14
Brianna K Swartwout, Marta G Zlotnick, Ashley E Saver, Caroline M McKenna, Andrea S Bertke
Zika virus (ZIKV) has recently surged in human populations, causing an increase in congenital and Guillain-Barré syndromes. While sexual transmission and presence of ZIKV in urine, semen, vaginal secretions, and saliva have been established, the origin of persistent virus shedding into biological secretions is not clear. Using a primary adult murine neuronal culture model, we have determined that ZIKV persistently and productively infects sensory neurons of the trigeminal and dorsal root ganglia, which innervate glands and mucosa of the face and the genitourinary tract, respectively, without apparent injury...
October 13, 2017: Pathogens
https://www.readbyqxmd.com/read/29027385/antimicrobial-susceptibilities-of-enterobacteriaceae-in-community-acquired-urinary-tract-infections-during-a-5-year-period-a-single-hospital-study-in-korea
#15
Jin Ju Park, Yu Bin Seo, Jacob Lee
BACKGROUND: Through investigating antimicrobial susceptibility patterns of Enterobacteriaceae in community-acquired urinary tract infection (CA-UTI), we provide basic evidence for the use of empirical antibiotics in CA-UTI. MATERIALS AND METHODS: We retrospectively reviewed the medical records of patients over the age of 19 years who visited a hospital in Seoul between January 2012 and December 2016 for a CA-UTI. Urine cultures were used to identify causative organisms...
September 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29026632/salmonella-oranienburg-haemorrhagic-cystitis-in-an-immunocompetent-young-male
#16
Jiasian Teh, Mark Quinlan, Damien Bolton
Introduction. Non-typhoidal salmonella (NTS) bacteriuria is extremely rare. Haemorrhagic cystitis is defined by urinary symptoms including haematuria, frequency, urgency and dysuria. Reports of haemorrhagic cystitis caused by NTS are exceptionally uncommon, especially in immunocompetent, young, male patients. Case presentation. A 27-year-old male with no past medical history presented to the Emergency Department with a 24 h history of visible haematuria having returned five days earlier from a five month trip across South America...
August 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29026619/16s-rrna-deep-sequencing-identifies-actinotignum-schaalii-as-the-major-component-of-a-polymicrobial-intra-abdominal-infection-and-implicates-a-urinary-source
#17
Andrew Bryan, Lindsey M Kirkpatrick, John J Manaloor, Stephen J Salipante
Introduction. It can be difficult to catalogue the individual organisms comprising polymicrobial patient infections, both because conventional clinical microbiological culture does not facilitate the isolation and enumeration of all members of a complex microbial community, and because fastidious organisms may be mixed with organisms that grow rapidly in vitro. Empiric antimicrobial treatment is frequently employed based on the anatomical site and the suspected source of the infection, especially when an appropriately collected surgical specimen is not obtained...
May 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29024820/coating-of-silicone-with-mannoside-pamam-dendrimers-to-enhance-formation-of-non-pathogenic-escherichia-coli-biofilms-against-colonization-of-uropathogens
#18
Zhiling Zhu, Fei Yu, Haoqing Chen, Jun Wang, Analette I Lopez, Quan Chen, Siheng Li, Yuyu Long, Rabih O Darouiche, Richard A Hull, Lijuan Zhang, Chengzhi Cai
Bacterial interference using non-pathogenic Escherichia coli 83972 is a novel strategy for preventing catheter-associated urinary tract infection (CAUTI). Crucial to the success of this strategy is to establish a high coverage and stable biofilm of the non-pathogenic bacteria on the catheter surface. However, this non-pathogenic strain is sluggish to form biofilms on silicone as the most widely used material for urinary catheters. We have addressed this issue by modifying the silicone catheter surfaces with mannosides that promote the biofilm formation, but the stability of the non-pathogenic biofilms challenged by uropathogens over long-term remains a concern...
October 9, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29024081/the-effect-of-rosa-l-rosa-canina-on-the-incidence-of-urinary-tract-infection-in-the-puerperium-a-randomized-placebo-controlled-trial
#19
Mahdieh Seifi, Shamsi Abbasalizadeh, Sakineh Mohammad-Alizadeh-Charandabi, Laleh Khodaie, Mojgan Mirghafourvand
Urinary tract infection (UTI) is an infection that can occur in any area of the urinary tract which is characterized by a positive urine culture (U/C). The risk of UTI following cesarean section (CS) increases due to procedures such as catheterization. In vitro studies have demonstrated the effect of Rosa canina fruit in preventing Escherichia coli growth. This study was conducted to determine the effect of R. canina fruit in preventing the incidence of UTI in women following CS. This triple-blind randomized clinical trial was conducted in 2016 on 400 women following CS with negative U/C in Alzahra and Taleghani educational hospitals in the city of Tabriz-Iran...
October 11, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29023188/preliminary-experience-with-instillation-of-triamcinolone-acetonide-into-the-urethra-for-idiopathic-urethritis-a-prospective-pilot-study
#20
Junaid Ashraf, Anna R Radford, Alexander Turner, Ramnath Subramaniam
BACKGROUND: Idiopathic bulbar urethritis (IBU) is characterized by hematuria ± dysuria without infection. Symptoms result from inflammation of the bulbar urethra, distal to external sphincter. IBU is difficult to manage and there is no recommended therapy. OBJECTIVE: To determine whether instillation of triamcinolone acetonide is a useful treatment of IBU and its associated complications. SETTING AND PARTICIPANTS: Data were prospectively collected, for 22 months, on 14 consecutive patients presenting with terminal hematuria or blood spotting ± dysuria to a pediatric urology unit...
October 12, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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