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https://www.readbyqxmd.com/read/28549070/the-atherogenic-index-of-plasma-and-the-risk-of-mortality-in-incident-dialysis-patients-results-from-a-nationwide-prospective-cohort-in-korea
#1
Mi Jung Lee, Jung Tak Park, Seung Hyeok Han, Yong-Lim Kim, Yon Su Kim, Chul Woo Yang, Nam-Ho Kim, Shin-Wook Kang, Hyung Jong Kim, Tae-Hyun Yoo
BACKGROUND: The atherogenic index of plasma (AIP), which is the logarithmic ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C), had a linear relationship with clinical outcomes in the general population. However, the association of each lipid profile, TG and HDL-C, with survival was not straightforward in dialysis patients. This non-linear association led us to further investigate the prognostic impact of the AIP in these patients. METHODS: From a nationwide prospective cohort, 1,174 incident dialysis patients were included...
2017: PloS One
https://www.readbyqxmd.com/read/28548974/remnant-lipoproteins
#2
Anette Varbo, Børge G Nordestgaard
PURPOSE OF REVIEW: To review recent advances in the field of remnant lipoproteins and remnant cholesterol with a focus on cardiovascular disease risk. RECENT FINDINGS: In line with previous years' research, current observational, genetic, and mechanistic studies find remnant lipoproteins (defined in different ways) to be involved in atherosclerosis development and cardiovascular disease risk. High concentrations of remnant cholesterol could explain some of the residual risk of cardiovascular disease seen after LDL cholesterol lowering...
May 25, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28546455/objectively-measured-sedentary-time-and-cardiovascular-risk-factor-control-in-us-hispanics-latinos-with-diabetes-mellitus-results-from-the-hispanic-community-health-study-study-of-latinos-hchs-sol
#3
Xueyin Wang, Garrett Strizich, Simin Hua, Daniela Sotres-Alvarez, Christina Buelna, Linda C Gallo, Marc D Gellman, Yasmin Mossavar-Rahmani, Matthew J O'Brien, Mark Stoutenberg, Tao Wang, M Larissa Avilés-Santa, Robert C Kaplan, Qibin Qi
BACKGROUND: Cardiovascular disease (CVD) risk factor control is a cornerstone of diabetes mellitus management. Little is known about relationships of objectively measured sedentary time and physical activity with major CVD risk factor control in individuals with diabetes mellitus. We examined associations of objectively measured sedentary time and moderate-to-vigorous physical activity with reaching major CVD risk factor control goals among US Hispanic/Latino adults with diabetes mellitus...
May 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28546454/effect-of-sodium-glucose-cotransport-2-inhibitors-on-blood-pressure-in-people-with-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis-of-43-randomized-control-trials-with-22-528-patients
#4
REVIEW
Mohsen Mazidi, Peyman Rezaie, Hong-Kai Gao, Andre Pascal Kengne
BACKGROUND: The sodium-glucose cotransporter 2 (SGLT2) inhibitors are a class of oral hypoglycemic agents. We undertake a systematic review and meta-analysis of prospective studies to determine the effect of SGLT2 on blood pressure (BP) among individuals with type 2 diabetes mellitus. METHODS AND RESULTS: PubMed-Medline, Web of Science, Cochrane Database, and Google Scholar databases were searched to identify trial registries evaluating the impact of SGLT2 on BP...
May 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28545518/design-and-rationale-of-the-odyssey-dm-dyslipidemia-trial-lipid-lowering-efficacy-and-safety-of-alirocumab-in-individuals-with-type-2-diabetes-and-mixed-dyslipidaemia-at-high-cardiovascular-risk
#5
Dirk Müller-Wieland, Lawrence A Leiter, Bertrand Cariou, Alexia Letierce, Helen M Colhoun, Stefano Del Prato, Robert R Henry, Francisco J Tinahones, Lisa Aurand, Jaman Maroni, Kausik K Ray, Maja Bujas-Bobanovic
BACKGROUND: Type 2 diabetes mellitus (T2DM) is often associated with mixed dyslipidaemia, where non-high-density lipoprotein cholesterol (non-HDL-C) levels may more closely align with cardiovascular risk than low-density lipoprotein cholesterol (LDL-C). We describe the design and rationale of the ODYSSEY DM-DYSLIPIDEMIA study that assesses the efficacy and safety of alirocumab, a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, versus lipid-lowering usual care in individuals with T2DM and mixed dyslipidaemia at high cardiovascular risk with non-HDL-C inadequately controlled despite maximally tolerated statin therapy...
May 25, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28545051/increased-risk-for-diabetes-development-in-subjects-with-large-variation-in-total-cholesterol-levels-in-2-827-950-koreans-a-nationwide-population-based-study
#6
Eun-Jung Rhee, Kyungdo Han, Seung-Hyun Ko, Kyung-Soo Ko, Won-Young Lee
BACKGROUND: Recent studies suggest a role for hyperlipidemia in the development of diabetes. The aim of this study is to analyze the relationship between variations of total cholesterol (TC) levels and the risk for type 2 diabetes development from a Korean nationwide population-based database. MATERIALS AND METHODS: We examined the General Health Check-up sub-dataset of the Korean National Health Insurance Service (NHIS) of 2,827,950 participants who had at least three health check-ups between 2002 and 2007, and were not reported to have diabetes during that time...
2017: PloS One
https://www.readbyqxmd.com/read/28544529/excess-cholesterol-inhibits-glucose-stimulated-fusion-pore-dynamics-in-insulin-exocytosis
#7
Yingke Xu, Derek K Toomre, Jonathan S Bogan, Mingming Hao
Type 2 diabetes is caused by defects in both insulin sensitivity and insulin secretion. Glucose triggers insulin secretion by causing exocytosis of insulin granules from pancreatic β-cells. High circulating cholesterol levels and a diminished capacity of serum to remove cholesterol from β-cells are observed in diabetic individuals. Both of these effects can lead to cholesterol accumulation in β-cells and contribute to β-cell dysfunction. However, the molecular mechanisms by which cholesterol accumulation impairs β-cell function remain largely unknown...
May 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28544171/effectiveness-of-shared-goal-setting-and-decision-making-to-achieve-treatment-targets-in-type-2-diabetes-patients-a-cluster-randomized-trial-optimal
#8
Henk Den Ouden, Rimke C Vos, Guy E H M Rutten
OBJECTIVE: About 20% of patients with type 2 diabetes achieve all their treatment targets. Shared decision making (SDM) using a support aid based on the 5-years results of the ADDITION study on multifactorial treatment, could increase this proportion. RESEARCH DESIGN AND METHODS: Cluster-randomized trial in 35 former ADDITION primary care practices. Practices were randomized to SDM or care as usual (1:1). Both ADDITION and non-ADDITION type 2 diabetes patients, 60-80 years, known with diabetes for 8-12 years, were included...
May 24, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28541489/respiratory-effects-and-systemic-stress-response-following-acute-acrolein-inhalation-in-rats
#9
Samantha J Snow, Marie A McGee, Andres Henriquez, Judy E Richards, Mette C Schladweiler, Allen D Ledbetter, Urmila P Kodavanti
Previous studies have demonstrated that exposure to the pulmonary irritant ozone causes myriad systemic metabolic and pulmonary effects attributed to sympathetic and hypothalamus-pituitary-adrenal (HPA) axis activation, which are exacerbated in metabolically-impaired models. We examined respiratory and systemic effects following exposure to a sensory irritant acrolein to elucidate the systemic and pulmonary consequences in healthy and diabetic rat models. Male Wistar and Goto Kakizaki (GK) rats, a non-obese type II diabetic Wistar-derived model, were exposed by inhalation to 0, 2, or 4 ppm acrolein, 4h/day for 1 or 2 days...
May 24, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28541040/metabolic-effect-of-1-deoxynojirimycin-from-mulberry-leaves-on-db-db-diabetic-mice-using-lc-ms-based-metabolomics
#10
Xue-Qin Hu, Kiran Thakur, Gui-Hai Chen, Fei Hu, Jian-Guo Zhang, Hong-Bin Zhang, Zhao-Jun Wei
Metabolomics was applied to LC-MS urinary metabolic profile of type 2 diabetes (T2DM) mice treated with mulberry 1-deoxynojirimycin (DNJ). The serum biochemical indicators related to T2DM like blood glucose, insulin, triglyceride, total cholesterol, nitrogen, malondialdehyde and creatinine decreased significantly in treated group. The histopathological changes in liver cells were marked by deformations and disruptions in central area of nuclei in DM mice, whereas, DNJ treatment recovered regular liver cells with normal nuclei...
May 25, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28540474/lipid-levels-and-risk-of-venous-thrombosis-results-from-the-mega-study
#11
Vânia M Morelli, Willem M Lijfering, Mettine H A Bos, Frits R Rosendaal, Suzanne C Cannegieter
The relationship between lipid levels and risk of venous thrombosis is not well established. We aimed to assess the association between several lipids and risk of venous thrombosis using data from a population-based case-control study, and to evaluate the underlying mechanism, considering confounding by common risk factors and mediation via hemostatic factors and C-reactive protein. From the Multiple Environmental and Genetic Assessment of risk factors for venous thrombosis (MEGA) study, 2234 patients with a first venous thrombosis and 2873 controls were included...
May 24, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28540395/management-of-atherosclerosis-risk-factors-for-patients-at-high-cardiovascular-risk-in-the-real-world-practice-a-multicentre-study
#12
Arintaya Phrommintikul, Rungroj Krittayaphong, Wanwarang Wongcharoen, Sukit Yamwong, Smonporn Boonyaratavej, Rapeephon Kunjara-Na-Ayudhya, Pyatat Tatsanavivat, Piyamitr Sritara
INTRODUCTION: Atherosclerotic cardiovascular disease is a global health burden. However, there are heterogeneities among countries or regions regarding the risk factors and clinical manifestations of atherosclerotic diseases as well as their management patterns. METHODS: We collected data from 25 centres in Thailand. Patients with documented coronary artery disease or cerebrovascular disease or peripheral arterial disease, or with at least three atherosclerosis risk factors were enrolled between April 2011 and March 2014...
May 25, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28539743/hepatoprotective-antihyperlipidemic-and-anti-inflammatory-activity-of-moringa-oleifera-in-diabetic-induced-damage-in-male-wistar-rats
#13
Elizabeth I Omodanisi, Yapo G Aboua, Novel N Chegou, Oluwafemi O Oguntibeju
BACKGROUND: The number of individuals with diabetes is increasing daily, and diabetes is presently estimated to affect about 422 million adults worldwide. Conventional drugs used to treat diabetes are not without severe side effects, accessibility, and affordability. This study elucidates the potential effects of Moringa oleifera (MO) leaves extract to manage and treat diabetes induced in male Wistar rats. MATERIALS AND METHODS: Adult male Wistar rats were randomly divided into four groups (n = 12/group): NC - nondiabetic rats (positive control), MO - nondiabetic-treated rats, DM - diabetic rats (negative control), DM + MO - diabetic-treated rats...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28539381/impact-of-chamber-dilatation-on-the-prognostic-value-of-left-ventricular-geometry-in-hypertension
#14
Paolo Verdecchia, Fabio Angeli, Giovanni Mazzotta, Claudia Bartolini, Marta Garofoli, Adolfo Aita, Cristina Poltronieri, Maria Gabriella Pinzagli, Francesca Valecchi, Stefania Martone, Elisa Ramundo, Dario Turturiello, Gianpaolo Reboldi
BACKGROUND: The different geometric patterns of the left ventricle may or may not coexist with chamber dilatation. The prognostic impact of such a combination is unclear. METHODS AND RESULTS: We studied a cohort of 2635 initially untreated patients with hypertension, mean age 50 years. At entry, 24-hour ambulatory blood pressure progressively increased across the patterns of normal geometry, concentric left ventricular (LV) remodeling, eccentric nondilated LV hypertrophy (LVH), eccentric dilated LVH, concentric nondilated LVH, and concentric dilated LVH...
May 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28539357/novel-association-of-tm6sf2-rs58542926-genotype-with-increased-serum-tyrosine-levels-and-decreased-apolipoprotein-b-100-particles-in-finns
#15
Daniel Seung Kim, Anne U Jackson, Yatong K Li, Heather M Stringham, Johanna Kuusisto, Antti J Kangas, Pasi Soininen, Mika Ala-Korpela, Charles F Burant, Veikko Salomaa, Michael Boehnke, Markku Laakso, Elizabeth K Speliotes
A glutamate-to-lysine variant (rs58542926-T) in transmembrane 6 superfamily member 2 (TM6SF2) is associated with increased fatty liver disease and diabetes in conjunction with decreased cardiovascular disease risk. To identify mediators of TM6SF2 effects, we tested for associations between rs58542926-T and serum lipoprotein/metabolite measures in cross-sectional data from non-diabetic, statin-naive participants. We identified independent associations between rs58542926-T and apolipoprotein B-100 particles (B=-0...
May 24, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28537802/seasonal-pattern-in-bipolar-disorders-and-cardio-vascular-risk-factors-a-study-from-the-face-bd-cohort
#16
Pierre A Geoffroy, Ophelia Godin, Diane Mahee, Chantal Henry, Valérie Aubin, Jean-Michel Azorin, Thierry Bougerol, Philippe Courtet, Sébastien Gard, Jean-Pierre Kahn, Christine Passerieux, Marion Leboyer, Frank Bellivier, Bruno Etain
Seasonal pattern (SP) and metabolic syndrome (MetS) are major contributors to poor outcome in bipolar disorders (BD). Patients with seasonal bipolar depression present increased appetite, carbohydrate cravings, weight gain, and hypersomnia, which can increase the development of MetS. MetS also appears to be associated with seasonal mood changes in the general population. This study examines whether a SP in BD is associated with an increased risk of MetS and its sub-components. One thousand four hundred and seventy-one outpatients with BD were systematically enrolled from 2009 to 2016...
May 24, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28537659/metformin-improves-the-glucose-and-lipid-metabolism-via-influencing-the-level-of-serum-total-bile-acids-in-rats-with-streptozotocin-induced-type-2-diabetes-mellitus
#17
X-M Meng, X-X Ma, Y-L Tian, Q Jiang, L-L Wang, R Shi, L Ding, S-G Pang
OBJECTIVE: To study the effects of metformin on streptozotocin-induced type 2 diabetes mellitus (T2DM) in rats. MATERIALS AND METHODS: Wistar male rats were divided into two groups: standard diet (SD, n = 20) group and high-fat diet (HFD, n = 80) group. Twenty rats in HFD group were randomly treated with metformin (EI group). After 6 weeks, among rats in HFD group, 20 rats were intraperitoneally injected with citrate buffered saline (IR group), 20 rats treated with metformin per day for 4 weeks (LI group), and 20 rats were given nothing (DM group)...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28537577/c-reactive-protein-in-brazilian-adolescents-distribution-and-association-with-metabolic-syndrome-in-erica-survey
#18
D T Giannini, M C C Kuschnir, C L de Oliveira, K V Bloch, B D Schaan, F V Cureau, K M B de Carvalho, G M Dias, M Szklo
BACKGROUND/OBJECTIVES: C-reactive protein (CRP) is a marker of inflammation that has been shown to be predictive of cardiovascular diseases in adults. To evaluate the distribution of CRP as well as its association with metabolic syndrome and its components. SUBJECTS/METHODS: This is a cross-sectional study on adolescents aged 12-17, participants in the Study of Cardiovascular Risk in Adolescents (ERICA). Anthropometric, biochemical and blood pressure data were collected from 6316 adolescents, selected from a random sample of students in the cities of Brasilia, Fortaleza, João Pessoa, Manaus, Porto Alegre and Rio de Janeiro...
May 24, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28536448/consumption-of-diets-with-low-advanced-glycation-end-products-improves-cardiometabolic-parameters-meta-analysis-of-randomised-controlled-trials
#19
Estifanos Baye, Velislava Kiriakova, Jaime Uribarri, Lisa J Moran, Barbora de Courten
Studies examining the effects of consumption of diets low in advanced glycation end products (AGEs) on cardiometabolic parameters are conflicting. Hence, we performed a meta-analysis to determine the effect of low AGE diets in reducing cardiometabolic risk factors. Seventeen randomised controlled trials comprising 560 participants were included. Meta-analyses using random effects models were used to analyse the data. Low AGE diets decreased insulin resistance (mean difference [MD] -1.3, 95% CI -2.3, -0.2), total cholesterol (MD -8...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28536154/gastric-bypass-surgery-produces-a-durable-reduction-in-cardiovascular-disease-risk-factors-and-reduces-the-long-term-risks-of-congestive-heart-failure
#20
Peter N Benotti, G Craig Wood, David J Carey, Vishal C Mehra, Tooraj Mirshahi, Michelle R Lent, Anthony T Petrick, Christopher Still, Glenn S Gerhard, Annemarie G Hirsch
BACKGROUND: Obesity and its association with reduced life expectancy are well established, with cardiovascular disease as one of the major causes of fatality. Metabolic surgery is a powerful intervention for severe obesity, resulting in improvement in comorbid diseases and in cardiovascular risk factors. This study investigates the relationship between metabolic surgery and long-term cardiovascular events. METHODS AND RESULTS: A cohort of Roux-en-Y gastric bypass surgery (RYGB) patients was tightly matched by age, body mass index, sex, Framingham Risk Score, smoking history, use of antihypertension medication, diabetes mellitus status, and calendar year with a concurrent cohort of nonoperated control patients...
May 23, 2017: Journal of the American Heart Association
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