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https://www.readbyqxmd.com/read/28942023/mirna-23-regulates-high-glucose-induced-epithelial-to-mesenchymal-transition-in-human-mesotheial-peritoneal-cells-by-targeting-vdr
#1
Lina Yang, Yi Fan, Xiuli Zhang, Jianfei Ma
Epithelial-mesenchymal transition(EMT) is the main reason for peritoneal fibrosis and the mechanism underlying peritoneal EMT were extensively studied in recent years. Recent researches showed that miRNAs were so important in the development of organ EMT and fibrosis, the role of microRNAs on peritoneal dialysis have also been studied. In the current study, we investigated microRNA-23(miR-23) expression in high glucose(HG) induced EMT in human mesotheial peritoneal cells(HPMCs). We found that HG promoted EMT, which was characterized by the upregulation of mesenchymal markers α-SMA and FN and downregulation of epithelial marker E-cadherin...
September 20, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28939378/polymorphic-phase-transitions-macroscopic-theory-and-molecular-simulation
#2
Jamshed Anwar, Dirk Zahn
Transformations in the solid state are of considerable interest, both for fundamental reasons and because they underpin important technological applications. The interest spans a wide spectrum of disciplines and application domains. For pharmaceuticals, a common issue is unexpected polymorphic transformation of the drug or excipient during processing or on storage, which can result in product failure. A more ambitious goal is that of exploiting the advantages of metastable polymorphs (e.g. higher solubility and dissolution rate) while ensuring their stability with respect to solid state transformation...
September 19, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28938827/excitation-and-desorption-of-physisorbed-h2-via-the%C3%AE-u2-electron-scattering-resonance
#3
Stig Andersson, Krister Svensson
Our high-resolution electron energy-loss measurements concern physisorbed H2 and comprise differential cross sections for the excitation of the internal H2 modes and the H2-surface bonding mode and their combinations and extend over the electron impact energy range of the classical low-energy H2 Σu2 resonance. Comparison with corresponding data for the excitation of the internal modes of gas phase H2 reveals that strong elastic electron reflectivity from the Cu(100) substrate profoundly distorts the inelastic scattering pattern for physisorbed H2...
September 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28936691/assessment-of-the-isodesmic-method-in-the-calculation-of-standard-reduction-potential-of-copper-complexes
#4
Diego Chaparro, Jorge Alí-Torres
Molecular phenomena involving electron transfer and reduction/oxidation processes are of the utmost importance in chemistry. However, accurate computational calculations of standard reduction potentials (SRPs) for transition metal complexes are still challenging. For this reason, some computational strategies have been proposed in order to overcome the main limitations in SRP calculations for copper complexes. However, these strategies are limited to particular coordination spheres and do not represent a general methodology...
September 21, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28935372/structural-insights-into-the-dimer-tetramer-transition-of-fabi-from-bacillus-anthracis
#5
Hyun Tae Kim, Sulhee Kim, Byeong Kwan Na, Jiwoung Chung, Eunha Hwang, Kwang Yeon Hwang
Enoyl-ACP reductase (ENR, also known as FabI) has received considerable interest as an anti-bacterial target due to its essentiality in fatty acid synthesis. All the FabI structures reported to date, regardless of the organism, are composed of homo-tetramers, except for two structures: Bacillus cereus and Staphylococcus aureus FabI (bcFabI and saFabI, respectively), which have been reported as dimers. However, the reason for the existence of the dimeric form in these organisms and the biological meaning of dimeric and tetrameric forms of FabI are ambiguous...
September 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28932204/how-followers-differing-in-career-motivation-gain-career-profits-from-transformational-leaders-a-longitudinal-moderated-mediation-model
#6
Anja Baethge, Thomas Rigotti, Sylvie Vincent-Hoeper
Although, transformational leadership is among the most thoroughly examined leadership theories, knowledge regarding its association with followers' career outcomes is still limited. Furthermore, the underlying mechanisms explaining how transformational leaders affect their employees' career success are yet not well-understood. Based on theoretical assumptions about the processes involved in setting the goal of "making a career," we propose an indirect effect of transformational leadership on subjective and objective career success via development opportunities that depends on the level of career motivation of employees...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28931911/terahertz-magneto-plasmonics-using-cobalt-subwavelength-aperture-arrays
#7
Barun Gupta, Shashank Pandey, Anjali Nahata, Berardi Sensale-Rodriguez, Sivaraman Guruswamy, Ajay Nahata
We characterize the terahertz (THz) magneto-plasmonic response of a cobalt-based periodic aperture array. The bare cobalt surface allows for low loss propagation of surface plasmon-polaritons, as evidenced by comparing the reflection from aperture arrays coated with Au and with Co. When an external magnetic field is applied in a polar Kerr geometry, we observe a maximum polarization rotation of ~0.6° and an ellipticity of ~0.35° from the Co-based array. These values are larger than expected based on existing models that include only interband transitions in ferromagnetic metals...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28929991/effects-of-different-dosages-of-propylene-glycol-in-dry-cows-and-cows-in-early-lactation
#8
Michaela Maurer, Walter Peinhopf, Jutta Gottschalk, Almut Einspanier, Gabor Koeller, Thomas Wittek
In this Research Paper we hypothesised that the temporary insulin resistance seen during the transition period in dairy cows may cause significant differences in the efficacy of PG at different sampling periods and that in some cases this effect will be dose dependent. Eighty four sampling sets were generated by studying 7 multiparous Holstein cows repeatedly at 4 sampling periods of 3 d length (dry cows: days 40, 39 and 38 antepartum; close up cows: days 10, 9 and 8 antepartum; fresh cows: days 3, 4 and 5 post-partum; lactating cows: days 38, 39 and 40 post-partum)...
September 20, 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/28921999/predictive-validity-and-adjustment-of-ideal-partner-preferences-across-the-transition-into-romantic-relationships
#9
Tanja M Gerlach, Ruben C Arslan, Thomas Schultze, Selina K Reinhard, Lars Penke
Although empirical research has investigated what we ideally seek in a romantic partner for decades, the crucial question of whether ideal partner preferences actually guide our mating decisions in real life has remained largely unanswered. One reason for this is the lack of designs that assess individuals' ideal partner preferences before entering a relationship and then follow up on them over an extended period. In the Göttingen Mate Choice Study (GMCS), a preregistered, large-scale online study, we used such a naturalistic prospective design...
September 18, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28921309/lung-cancer-associated-brain-metastasis-molecular-mechanisms-and-therapeutic-options
#10
REVIEW
Meysam Yousefi, Tayyeb Bahrami, Arash Salmaninejad, Rahim Nosrati, Parisa Ghaffari, Seyed H Ghaffari
BACKGROUND: Lung cancer is the most common cause of cancer-related mortality in humans. There are several reasons for this high rate of mortality, including metastasis to several organs, especially the brain. In fact, lung cancer is responsible for approximately 50% of all brain metastases, which are very difficult to manage. Understanding the cellular and molecular mechanisms underlying lung cancer-associated brain metastasis brings up novel therapeutic promises with the hope to ameliorate the severity of the disease...
September 18, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28918606/kinetic-coupling-of-phosphate-release-force-generation-and-rate-limiting-steps-in-the-cross-bridge-cycle
#11
Robert Stehle, Chiara Tesi
A basic goal in muscle research is to understand how the cyclic ATPase activity of cross-bridges is converted into mechanical force. A direct approach to study the chemo-mechanical coupling between Pi release and the force-generating step is provided by the kinetics of force response induced by a rapid change in [Pi]. Classical studies on fibres using caged-Pi discovered that rapid increases in [Pi] induce fast force decays dependent on final [Pi] whose kinetics were interpreted to probe a fast force-generating step prior to Pi release...
September 16, 2017: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/28918549/loss-of-lhci-system-affects-lhcii-re-distribution-between-thylakoid-domains-upon-state-transitions
#12
Mauro Bressan, Roberto Bassi, Luca Dall'Osto
LHCI, the peripheral antenna system of Photosystem I, includes four light-harvesting proteins (Lhca1-Lhca4) in higher plants, all of which are devoid in the Arabidopsis thaliana knock-out mutant ΔLhca. PSI absorption cross-section was reduced in the mutant, thus affecting the redox balance of the photosynthetic electron chain and resulting in a more reduced PQ with respect to the wild type. ΔLhca plants developed compensatory response by enhancing LHCII binding to PSI. However, the amplitude of state transitions, as measured from changes of chlorophyll fluorescence in vivo, was unexpectedly low than the high level of PSI-LHCII supercomplex established...
September 16, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28917699/the-impact-of-aging-on-subregions-of-the-hippocampal-complex-in-healthy-adults
#13
Florian Kurth, Nicolas Cherbuin, Eileen Luders
The hippocampal complex, an anatomical composite of several subregions, is known to decrease in size with increasing age. However, studies investigating which subregions are particularly prone to age-related tissue loss revealed conflicting findings. Possible reasons for such inconsistencies may reflect differences between studies in terms of the cohorts examined or techniques applied to define and measure hippocampal subregions. In the present study, we enhanced conventional MR-based information with microscopically defined cytoarchitectonic probabilities to investigate aging effects on the hippocampal complex in a carefully selected sample of 96 healthy subjects (48 males/48 females) aged 18-69 years...
September 13, 2017: NeuroImage
https://www.readbyqxmd.com/read/28915001/design-of-donor-polymers-with-strong-temperature-dependent-aggregation-property-for-efficient-organic-photovoltaics
#14
Huawei Hu, Philip C Y Chow, Guangye Zhang, Tingxuan Ma, Jing Liu, Guofang Yang, He Yan
Bulk heterojunction (BHJ) organic solar cells (OSCs) have attracted intensive research attention over the past two decades owing to their unique advantages including mechanical flexibility, light weight, large area, and low-cost fabrications. To date, OSC devices have achieved power conversion efficiencies (PCEs) exceeding 12%. Much of the progress was enabled by the development of high-performance donor polymers with favorable morphological, electronic, and optical properties. A key problem in morphology control of OSCs is the trade-off between achieving small domain size and high polymer crystallinity, which is especially important for the realization of efficient thick-film devices with high fill factors...
September 15, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28913950/do-transgender-children-gender-stereotype-less-than-their-peers-and-siblings
#15
Kristina R Olson, Elizabeth A Enright
In the present work, we ask whether socially transitioned, transgender children differ from other children in their endorsement of gender stereotypes and response to others' gender nonconformity. We compare transgender children (N = 56) to a group of siblings of transgender children (N = 37), and a group of unrelated control participants (N = 56) during middle childhood (ages 6-8 years old). Our results indicate that transgender children and the siblings of transgender children endorse gender stereotypes less than the control group...
September 15, 2017: Developmental Science
https://www.readbyqxmd.com/read/28906516/a-highly-fluorinated-lithium-iron-phosphate-with-interpenetrating-lattices-electrochemistry-and-ionic-conductivity
#16
Hooman Yaghoobnejad Asl, Kartik Ghosh, Amitava Choudhury
Li5Fe2PO4F8, a new member of the family of alkali transition metal fluorophosphates, has been synthesized and characterized using single-crystal X-ray diffraction, (57)Fe Mössbauer spectroscopy and magnetic susceptibility measurements. The existence of an infinite {-[PO4(FeF4)2]-}∞ tetrahedral network in an inter-penetrated diamond lattice, along with the presence of seven unique Li sites, presents interesting structural features of this structure-type for energy storage applications. The initial results of (de)lithiation reveal that a relatively low fraction of theoretical capacity may be utilized reversibly (0...
September 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28904351/localized-itinerant-dichotomy-and-unconventional-magnetism-in-srru2o6
#17
Satoshi Okamoto, Masayuki Ochi, Ryotaro Arita, Jiaqiang Yan, Nandini Trivedi
Electron correlations tend to generate local magnetic moments that usually order if the lattices are not too frustrated. The hexagonal compound SrRu2O6 has a relatively high Neel temperature but small local moments, which seem to be at odds with the nominal valence of Ru(5+) in the [Formula: see text] configuration. Here, we investigate the electronic property of SrRu2O6 using density functional theory (DFT) combined with dynamical-mean-field theory (DMFT). We find that the strong hybridization between Ru d and O p states results in a Ru valence that is closer to +4, leading to the small ordered moment ~1...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28903578/mental-health-services-use-trends-in-canadian-veterans-a-population-based-retrospective-cohort-study-in-ontario
#18
Alyson L Mahar, Alice B Aiken, Heidi Cramm, Marlo Whitehead, Patti Groome, Paul Kurdyak
OBJECTIVE: A substantial evidence base in the peer-reviewed literature exists investigating mental illness in the military, but relatively less is documented about mental illness in veterans. This study uses provincial, administrative data to study the use of mental health services by Canadian veterans in Ontario. METHOD: This was a retrospective cohort study of Canadian Armed Forces and Royal Canadian Mounted Police veterans who were released between 1990 and 2013 and resided in Ontario...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28900771/health-concerns-and-health-service-utilization-in-a-population-cohort-of-young-adults-with-autism-spectrum-disorder
#19
Jonathan A Weiss, Barry Isaacs, Heidi Diepstra, Andrew S Wilton, Hilary K Brown, Caitlin McGarry, Yona Lunsky
Individuals with autism spectrum disorder (ASD) have many health needs that place demands on the health service sector. This study used administrative data to compare health profiles in young adults 18-24 years of age with ASD to peers with and without other developmental disability. Young adults with ASD were more likely to have almost all the examined clinical health issues and health service use indicators compared to peers without developmental disability. They were more likely to have at least one psychiatric diagnosis, and visit the family physician, pediatrician, psychiatrist, and emergency department for psychiatric reasons, compared to peers with other developmental disability...
September 13, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28898958/radiotherapy-for-laryngeal-cancer-technical-aspects-and-alternate-fractionation
#20
Hideya Yamazaki, Gen Suzuki, Satoaki Nakamura, Ken Yoshida, Koji Konishi, Teruki Teshima, Kazuhiko Ogawa
Early laryngeal, especially glottic, cancer is a good candidate for radiotherapy because obvious early symptoms (e.g. hoarseness) make earlier treatment possible and with highly successful localized control. This type of cancer is also a good model for exploring the basic principles of radiation oncology and several key findings (e.g. dose, fractionation, field size, patient fixation, and overall treatment time) have been noted. For example, unintended poor outcomes have been reported during transition from 60Cobalt to linear accelerator installation in the 1960s, with usage of higher energy photons causing poor dose distribution...
July 1, 2017: Journal of Radiation Research
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