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https://www.readbyqxmd.com/read/28095887/association-between-midlife-health-behaviours-and-transitions-out-of-employment-from-midlife-to-early-old-age-whitehall-ii-cohort-study
#1
Gareth Hagger-Johnson, Ewan Carr, Emily Murray, Stephen Stansfeld, Nicola Shelton, Mai Stafford, Jenny Head
BACKGROUND: It is important to determine whether unhealthy behaviours might influence transitions out of employment from midlife to old age, given the anticipated need for adults to work for longer. Our aim was to determine the association between repeated assessments of cigarette smoking, heavy/problem alcohol drinking, low physical activity and poor diet at midlife, in relation to work exit from midlife to old age. METHODS: Data from 7704 participants (5392 men) from the Whitehall II cohort study in employment at midlife were used to evaluate the association between unhealthy behaviours and a subsequent transition out of work during 22 years follow-up, using logistic regression models...
January 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28094971/predicting-nanoscale-dynamics-of-a-glass-forming-liquid-from-its-macroscopic-bulk-behavior-and-vice-versa
#2
Karolina Adrjanowicz, Kamil Kaminski, Magdalena Tarnacka, Grzegorz Szklarz, Marian Paluch
The properties of a molecular liquid confined at the nanometer length scale can be very much distinct from the bulk. For that reason, the macro- and the nanoscopic behaviors of glass-forming liquids are regarded as two non-connected realms, governed by their own rules. Here, we show that the glassy dynamics in molecular liquids confined to nanometer pores might obey the density scaling relation, /T, just like in bulk fluids. Even more surprisingly, the same value of the scaling exponent  superposes the -relaxation time measured at different state points in nanoscale confinement and on increased pressure...
January 17, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28094601/recruiting-newly-referred-lung-cancer-patients-to-a-patient-navigator-intervention-paco-lessons-learnt-from-a-pilot-study
#3
Trille Kristina Kjær, Anders Mellemgaard, Marianne Stensøe Oksen, Bo Andreassen Rix, Randi Karlsen, Christoffer Johansen, Susanne Oksbjerg Dalton
OBJECTIVES: The incidence of and survival from lung cancer are associated with socioeconomic position, and disparities have been observed in both curative and palliative treatment for lung cancer. 'Patient navigation' is valuable in addressing health disparity, with timely treatment and transition to care. We conducted a pilot study to test the feasibility of a patient navigator program (PAtient COach) for newly diagnosed lung cancer. We present the trial, the findings from the pilot study and discuss factors that might have affected recruitment rates...
January 17, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28091752/management-of-secondary-hyperparathyroidism-practice-patterns-and-outcomes-of-cinacalcet-treatment-with-or-without-active-vitamin%C3%A2-d-in-austria-and-switzerland-the-observational-transit-study
#4
Wolfgang Pronai, Alexander R Rosenkranz, Andreas Bock, Renate Klauser-Braun, Christine Jäger, Gunther Pendl, Margit Hemetsberger, Karl Lhotta
Secondary hyperparathyroidism is a complex disorder requiring an individualized multicomponent treatment approach. This study was conducted to identify treatment combinations used in clinical practice in Austria and Switzerland and the potential to control this disorder. A total of 333 adult hemodialysis and peritoneal dialysis patients were analyzed. All patients received conventional care prior to initiation of a cinacalcet-based regimen. During the study, treatment components, e.g. cinacalcet, active vitamin D analogues and phosphate binders, were adapted to individual patient requirements and treatment dynamics were documented...
January 13, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28091712/two-cases-of-female-urethral-reconstruction-with-acellular-porcine-urinary-bladder-matrix
#5
Sana Ansari, Mickey Karram
INTRODUCTION AND HYPOTHESIS: Female urethral reconstruction via the traditional routes can be limiting for various reasons. Current literature on the use of acellular biologic grafts derived from viscera for female urethral reconstruction is limited. We present two cases of women with complete loss of their posterior urethra presenting for urethral reconstruction. METHODS: Two cases of urethral reconstruction using acellular porcine urinary bladder matrix (UBM), along with labial fat pad transposition and biologic pubovaginal sling are presented...
January 13, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28089368/the-transition-from-pediatric-to-adult-care-for-youth-with-epilepsy-basic-biological-sociological-and-psychological-issues
#6
REVIEW
Peter Camfield, Carol Camfield, Kanetee Busiah, David Cohen, Alison Pack, Rima Nabbout
Transition from pediatric to adult health care for adolescents with epilepsy is challenging for the patient, family, and health care workers. This paper is the first of three that summarize the main findings from the 2nd Symposium on Transition in Epilepsies, held in Paris from June 14-25, 2016. In this paper we describe five basic themes that have an important effect on transition. First, there are important brain changes in adolescence that leave an imbalance between risk taking and pleasure seeking behaviors and frontal executive function compared with adults...
January 12, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28087554/how-prepared-are-uk-medical-graduates-for-practice-a-rapid-review-of-the-literature-2009-2014
#7
Lynn V Monrouxe, Lisa Grundy, Mala Mann, Zoe John, Eleni Panagoulas, Alison Bullock, Karen Mattick
OBJECTIVE: To understand how prepared UK medical graduates are for practice and the effectiveness of workplace transition interventions. DESIGN: A rapid review of the literature (registration #CRD42013005305). DATA SOURCES: Nine major databases (and key websites) were searched in two timeframes (July-September 2013; updated May-June 2014): CINAHL, Embase, Educational Resources Information Centre, Health Management Information Consortium, MEDLINE, MEDLINE in Process, PsycINFO, Scopus and Web of Knowledge...
January 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28078483/theoretical-characterization-on-photoelectric-properties-of-benzothiadiazole-and-fluorene-based-small-molecule-acceptor-materials-for-the-organic-photovoltaics
#8
Mingyue Sui, Shuangbao Li, Qingqing Pan, Guangyan Sun, Yun Geng
The upper efficiency of heterojunction organic photovoltaics depends on the increased open-circuit voltage (V oc) and short-circuit current (J sc). So, a higher lowest unoccupied molecular orbital (LUMO) level is necessary for organic acceptor material to possess higher V oc and more photons absorbsorption in the solar spectrum is needed for larger J sc. In this article, we theoretically designed some small molecule acceptors (2∼5) based on fluorene (F), benzothiadiazole, and cyano group (CN) referring to the reported acceptor material 2-[{7-(9,9-di-n-propyl-9H-fluoren-2-yl)benzo[c][1,2,5]thiadiazol-4-yl}methylene]malononitrile (1), the crucial parameters affecting photoelectrical properties of compounds 2∼5 were evaluated by the density functional theory (DFT) and time dependent density functional theory (TDDFT) methods...
January 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28078454/measuring-competency-development-in-objective-evaluation-of-videofluoroscopic-swallowing-studies
#9
Natrah Ahmad Nordin, Anna Miles, Jacqui Allen
Clinical interpretation of videofluoroscopic swallow study (VFSS) has often been criticized for its poor objectivity and inter-rater agreement. In order to address this, objective VFSS measures have been developed, reported and demonstrated to be valid and reliable. However, widespread clinical implementation is lacking. Reasons cited include lack of training and excessive time taken to perform measures. This study investigated competency development in selected standardized objective VFSS measures among speech-language pathologists (SLPs) naive to quantitative measurement...
January 11, 2017: Dysphagia
https://www.readbyqxmd.com/read/28076383/time-varying-transition-probability-matrix-estimation-and-its-application-to-brand-share-analysis
#10
Tomoaki Chiba, Hideitsu Hino, Shotaro Akaho, Noboru Murata
In a product market or stock market, different products or stocks compete for the same consumers or purchasers. We propose a method to estimate the time-varying transition matrix of the product share using a multivariate time series of the product share. The method is based on the assumption that each of the observed time series of shares is a stationary distribution of the underlying Markov processes characterized by transition probability matrices. We estimate transition probability matrices for every observation under natural assumptions...
2017: PloS One
https://www.readbyqxmd.com/read/28075570/contrasting-behavior-of-the-z-bonds-in-x-z%C3%A2-%C3%A2-%C3%A2-y-weak-interactions-z-main-group-elements-versus-the-transition-metals
#11
Jyothish Joy, Eluvathingal D Jemmis
In contrast to the increasing family of weak intermolecular interactions in main-group compounds (X-Z···Y, Z = main-group elements), an analysis of the Cambridge Structural Database indicates that electron-saturated (18-electron) transition-metal complexes show reluctance toward weak M bond formation (X-M···Y, M = transition metal). In particular, weak M bonds involving electron-saturated (18-electron) complexes of transition metals with partially filled d-orbitals are not found. We propose that the nature of valence electron density distribution in transition-metal complexes is the primary reason for this reluctance...
January 11, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28069878/malat1-is-associated-with-poor-response-to-oxaliplatin-based-chemotherapy-in-colorectal-cancer-patients-and-promotes-chemoresistance-through-ezh2
#12
Peilong Li, Xin Zhang, Haiyan Wang, Lili Wang, Tong Liu, Lutao Du, Yongmei Yang, Chuanxin Wang
A major reason for oxaliplatin chemoresistance in colorectal cancer (CRC) is the acquisition of epithelial-mesenchymal transition (EMT) in cancer cells. The long non-coding RNA, MALAT1, is a highly conserved nuclear ncRNA and a key regulator of metastasis development in several cancers. However, its role in oxaliplatin-induced metastasis and chemo-resistance is not well known. In this study, we aim to investigate the prognostic and therapeutic role of MALAT1 in CRC patients receiving oxaliplatin-based therapy, and further explore the potential transcriptional regulation through interaction with EZH2 based on the established HT29 oxaliplatin-resistant cells...
January 9, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28067283/theoretical-insight-into-oh-and-cl-initiated-oxidation-of-cf3och-cf3-2-and-cf3ocf2cf2h-fate-of-cf3oc-x%C3%A2-cf3-2-and-cf3ocf2cf2x%C3%A2-radicals-x-o-o2
#13
Feng-Yang Bai, Yuan Ma, Shuang Lv, Xiu-Mei Pan, Xiu-Juan Jia
In this study, the mechanistic and kinetic analysis for reactions of CF3OCH(CF3)2 and CF3OCF2CF2H with OH radicals and Cl atoms have been performed at the CCSD(T)//B3LYP/6-311++G(d,p) level. Kinetic isotope effects for reactions CF3OCH(CF3)2/CF3OCD(CF3)2 and CF3OCF2CF2H/CF3OCF2CF2D with OH and Cl were estimated so as to provide the theoretical estimation for future laboratory investigation. All rate constants, computed by canonical variational transition state theory (CVT) with the small-curvature tunneling correction (SCT), are in reasonable agreement with the limited experimental data...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28065611/-diet-and-lifestyle-rules-in-chronic-constipation-in-adults-from-fantasy-to-reality%C3%A2
#14
Nadia Fathallah, Dominique Bouchard, Vincent de Parades
Chronic constipation is one of the most common chronic gastrointestinal complaints and a frequent reason for consultation. Lifestyle modification and dietary advice attract a lot of patients, often dissatisfied with a long-term drug intake. These behavioral modifications are recommended as a first-line approach in the treatment of chronic mild constipation in the majority of current guidelines despite a low level of evidence. Fiber supplementation is probably the most relevant measure because of a satisfactory level of proof...
January 5, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28064436/mir-181b-5p-ets1-and-c-met-pathway-exacerbates-the-prognosis-of-pancreatic-ductal-adenocarcinoma-after-radiation-therapy
#15
Hideo Tomihara, Daisaku Yamada, Hidetoshi Eguchi, Yoshifumi Iwagami, Takehiro Noda, Tadafumi Asaoka, Hiroshi Wada, Koichi Kawamoto, Kunihito Gotoh, Yutaka Takeda, Masahiro Tanemura, Masaki Mori, Yuichiro Doki
Preoperative chemoradiation therapy (CRT) for pancreatic ductal adenocarcinoma (PDAC) has emerged as a reasonable strategy that shows good prognostic impact. However, after preoperative CRT, resected specimens exhibited remnant tumor cells, which indicated that some tumor cells had acquired or were selected for resistance to CRT. Recently, two oncological mechanisms, the epithelial-mesenchymal transition (EMT) and the presence of cancer stem cells (CSCs) were reported to be associated with resistance in various cancers...
January 8, 2017: Cancer Science
https://www.readbyqxmd.com/read/28063453/does-the-configurational-entropy-of-polydisperse-particles-exist
#16
Misaki Ozawa, Ludovic Berthier
Classical particle systems characterized by continuous size polydispersity, such as colloidal materials, are not straightforwardly described using statistical mechanics, since fundamental issues may arise from particle distinguishability. Because the mixing entropy in such systems is divergent in the thermodynamic limit, we show that the configurational entropy estimated from standard computational approaches to characterize glassy states also diverges. This reasoning would suggest that polydisperse materials cannot undergo a glass transition, in contradiction to experiments...
January 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28060961/pilot-study-estimation-of-stroke-volume-and-cardiac-output-from-pulse-wave-velocity
#17
Yurie Obata, Maki Mizogami, Daniel Nyhan, Dan E Berkowitz, Jochen Steppan, Viachaslau Barodka
BACKGROUND: Transesophageal echocardiography (TEE) is increasingly replacing thermodilution pulmonary artery catheters to assess hemodynamics in patients at high risk for cardiovascular morbidity. However, one of the drawbacks of TEE compared to pulmonary artery catheters is the inability to measure real time stroke volume (SV) and cardiac output (CO) continuously. The aim of the present proof of concept study was to validate a novel method of SV estimation, based on pulse wave velocity (PWV) in patients undergoing cardiac surgery...
2017: PloS One
https://www.readbyqxmd.com/read/28060478/three-dimensional-graphene-single-walled-carbon-nanotube-aerogel-anchored-with-sno2-nanoparticles-for-high-performance-lithium-storage
#18
Jing Wang, Fang Fang, Tao Yuan, Junhe Yang, Liang Chen, Chi Yao, Shiyou Zheng, Dalin Sun
A unique 3D graphene-single wall carbon nanotube (G-SWNT) aerogel anchored with SnO2 nanoparticles (SnO2@G-SWCNT) is fabricated by hydrothermal self-assembly process. The influences of mass ratio of SWCNT to graphene on structure and electrochemical properties of SnO2@G-SWCNT are investigated systematically. The SnO2@G-SWCNT composites show excellent electrochemical performance in Li-ion batteries, for instance, at a current density of 100 mA g-1, a specific capacity of 758 mAh g-1 was obtained for the SnO2@G-SWCNT with 50 % SWCNT in G-SWCNT and the coulombic efficiency is close to 100 % after 200 cycles; even at current density of 1 A g-1, it can still maintain a stable specific capacity of 537 mAh g-1 after 300 cycles...
January 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28057371/3-meo-pcp-intoxication-in-two-young-men-first-in-vivo-detection-in-italy
#19
Elisabetta Bertol, Jennifer Pascali, Diego Palumbo, Valeria Catalani, Maria Grazia Di Milia, Alessia Fioravanti, Francesco Mari, Fabio Vaiano
3-MeO-PCP or 3-methoxyphencyclidine is a derivative of phencyclidine. It acts as a dissociative anesthetic and it has allegedly hallucinogenic and sedative effects. There are almost no documented intoxication cases and references about its pharmacology and toxicity in literature. This study presents two concomitant intoxication cases due to consumption of 3-MeO-PCP and alcohol. A 19 (A) and a 21 years old (B) men were brought to Santa Maria Nuova Hospital in a comatose state (Glasgow score 3). They showed respiratory acidosis, right anisocoria with mydriatic pupils and hypothermia...
December 26, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28056738/microtubule-targeting-agents-as-cancer-chemotherapeutics-an-overview-of-molecular-hybrids-as-stabilising-and-destabilising-agents
#20
Anjana Devi Tangutur, Dinesh Kumar, Kommalapati Vamsi Krishna, Srinivas Kantevari, Anjana Devi Tangutur, Dinesh Kumar, Kommalapati Vamsi Krishna, Srinivas Kantevari
Microtubules form crucial dynamic structural cellular components of the cell and are composed of the alpha beta tubulin heterodimers. Microtubules are involved in a wide variety of functions in the cell such as attribution to cell shape, motility, intracellular trafficking and mitotic spindle formation. Owing to these reasons, tubulin and microtubules have gained significant interest as important targets for cancer therapy. A review of the existing microtubule targeting drugs specifies that these agents can be categorised into two of the major categories: Microtubule stabilising agents such as paclitaxel, docetaxel, epothilones, and discodermolide which bind to the tubulin polymer and stabilize the microtubules, microtubule destabilising agents such as vinca alkaloids, colchicine and combretastatins which bind to tubulin dimers and cause destabilisation...
January 4, 2017: Current Topics in Medicinal Chemistry
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