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https://www.readbyqxmd.com/read/28522797/protective-effects-of-hydrogen-rich-saline-against-lipopolysaccharide-induced-alveolar-epithelial-to-mesenchymal-transition-and-pulmonary-fibrosis
#1
Wen-Wen Dong, Yun-Qian Zhang, Xiao-Yan Zhu, Yan-Fei Mao, Xue-Jun Sun, Yu-Jian Liu, Lai Jiang
BACKGROUND Fibrotic change is one of the important reasons for the poor prognosis of patients with acute respiratory distress syndrome (ARDS). The present study investigated the effects of hydrogen-rich saline, a selective hydroxyl radical scavenger, on lipopolysaccharide (LPS)-induced pulmonary fibrosis. MATERIAL AND METHODS Male ICR mice were divided randomly into 5 groups: Control, LPS-treated plus vehicle treatment, and LPS-treated plus hydrogen-rich saline (2.5, 5, or 10 ml/kg) treatment. Twenty-eight days later, fibrosis was assessed by determination of collagen deposition, hydroxyproline, and type I collagen levels...
May 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28513668/computational-analysis-of-site-differences-in-selective-aliphatic-c-h-hydroxylation-by-nonheme-iron-oxo-complexes
#2
Jian Wang, Yuan-Yuan Zhao, Po-Heng Lee
Selective C-H hydroxylation by nonheme iron complexes offers a promising method in the field of organic synthesis. Aliphatic C-H bond oxidation reactions of pivalate (R) catalyzed by [Fe(S,S-PDP)(CH3CN)2](2+) (CAT1) were examined using the density functional theory. Our calculations of the CH3CN solvent agree with the experimental findings. However, it was observed that the gas-phase results did not replicate selective C-H hydroxylation observed experimentally when CAT1 catalyzed hydrocarbon oxidations by H2O2via an HO-Fe(V)[double bond, length as m-dash]O oxidant (CAT1a)...
May 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28507606/transcription-and-chromatin-determinants-of-de-novo-dna-methylation-timing-in-oocytes
#3
Lenka Gahurova, Shin-Ichi Tomizawa, Sébastien A Smallwood, Kathleen R Stewart-Morgan, Heba Saadeh, Jeesun Kim, Simon R Andrews, Taiping Chen, Gavin Kelsey
BACKGROUND: Gametogenesis in mammals entails profound re-patterning of the epigenome. In the female germline, DNA methylation is acquired late in oogenesis from an essentially unmethylated baseline and is established largely as a consequence of transcription events. Molecular and functional studies have shown that imprinted genes become methylated at different times during oocyte growth; however, little is known about the kinetics of methylation gain genome wide and the reasons for asynchrony in methylation at imprinted loci...
2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28506849/phase-2-to-phase-3-clinical-trial-transitions-reasons-for-success-and-failure-in-immunologic-diseases
#4
EDITORIAL
Dhavalkumar D Patel, Christian Antoni, Steven J Freedman, Marc C Levesque, John S Sundy
No abstract text is available yet for this article.
May 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28501631/plasmid-transfection-in-bovine-cells-optimization-using-a-realtime-monitoring-of-green-fluorescent-protein-and-effect-on-gene-reporter-assay
#5
J S Osorio, M Bionaz
Gene reporter technology (GRT) has opened several new avenues for monitoring biological events including the activation of transcription factors, which are central to the study of nutrigenomics. However, this technology relies heavily on the insertion of foreign plasmid DNA into the nuclei of cells (i.e., transfection), which can be very challenging and highly variable among cell types. The objective of this study was to investigate the optimal conditions to generate reliable GRT assay data on bovine immortalized cell lines, Madin Darby Bovine Kidney (MDBK) and bovine mammary epithelial alveolar (MACT) cells...
May 10, 2017: Gene
https://www.readbyqxmd.com/read/28498379/non-pericyclic-cycloaddition-of-gem-difluorosubstituted-azomethine-ylides-to-the-c-double-bond-length-as-m-dash-o-bond-computational-study-and-synthesis-of-fluorinated-oxazole-derivatives
#6
Karina R Gaisina, Alexander F Khlebnikov, Mikhail S Novikov
The cycloaddition of arenecarbaldehydes and α,α,α-trifluoroacetophenones with gem-difluoro-substituted azomethine ylides, generated from N-benzhydrylideneamines and difluorocarbene, occurs regioselectively to give, after hydrolysis, oxazolidin-4-ones. The primary cycloadducts of trifluoroacetophenones, 4,4-difluoro-5-trifluoromethyloxazolidine derivatives, are sufficiently stable to be isolated in reasonable to excellent yields. The results of correlation analysis and DFT calculations reveal a non-pericyclic step-wise mechanism of the reaction...
May 12, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28497971/9-9-difluorobispidine-analogues-of-cisplatin-carboplatin-and-oxaliplatin
#7
Raja Mitra, Richard Goddard, Klaus-Richard Pörschke
As part of a comprehensive study of N-unsubstituted bispidines, the novel 9,9-difluorobispidine (D) has been synthesized. The compound crystallizes from pentane below 0 °C in the ordered-crystalline phase D-II and undergoes at 0-30 °C a stepwise endothermic phase transition to a dynamically disordered crystalline phase D-I; melting occurs at 227 °C. Single crystalline D-II has been subjected to X-ray structure analysis, revealing association of the molecules to form chains. Reaction of (1,5-hexadiene)PtCl2 with D affords {C7H10F2(NH)2}PtCl2 (D1), which can be converted by conventional routes to {C7H10F2(NH)2}Pt(cbdca)·5H2O (D2) and {C7H10F2(NH)2}Pt(C2O4) (D3)...
May 12, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28493717/-2-2-type-reaction-of-metal-metal-%C3%AF-bond-with-fullerene-forming-an-%C3%AE-1-c60-metal-complex-mechanistic-details-of-formation-reaction-and-prediction-of-a-new-%C3%AE-1-c60-metal-complex
#8
Hong Zheng, Xiang Zhao, Shigeyoshi Sakaki
C60[CpRu(CO)2]2 is only one transition-metal fullerene complex with pure η(1)-coordinated bonds, which was recently synthesized through the reaction between dinuclear Ru complex [CpRu(CO)2]2 and C60. Though new properties can be expected in the η(1)-coordinated metal-fullerene complex, its characteristic features are unclear, and the [2 + 2]-type formation reaction is very slow with a very small yield. A density functional theory study discloses that the η(1)-coordinated bond is formed by a large overlap between the Ru dσ orbital and C pσ one involved in the lowest unoccupied molecular orbital (LUMO) (π*) of C60 unlike the well-known η(2)-coordinated metal-fullerene complex which has a π-type coordinate bond with metal dπ orbital...
May 11, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28492458/switching-from-the-oral-to-the-depot-formulation-of-a-medication-clinically-relevant-pharmacokinetic-concepts-and-considerations
#9
Sheldon H Preskorn
This column presents principles that will aid the prescriber in transitioning patients from an oral to a depot antipsychotic medication. The column covers the differences in the pharmacokinetics of oral versus depot formulations that are critical in making a smooth transition. Also discussed are some of the reasons to use these medications, which, in the author's opinion, are currently underutilized. This column focuses on the big picture and the fundamentals of oral versus depot formulations rather than comparing the relative merits or potential advantages of the various marketed depot formulations...
May 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28489866/magmatic-evolution-of-panama-canal-volcanic-rocks-a-record-of-arc-processes-and-tectonic-change
#10
David W Farris, Agustin Cardona, Camilo Montes, David Foster, Carlos Jaramillo
Volcanic rocks along the Panama Canal present a world-class opportunity to examine the relationship between arc magmatism, tectonic forcing, wet and dry magmas, and volcanic structures. Major and trace element geochemistry of Canal volcanic rocks indicate a significant petrologic transition at 21-25 Ma. Oligocene Bas Obispo Fm. rocks have large negative Nb-Ta anomalies, low HREE, fluid mobile element enrichments, a THI of 0.88, and a H2Ocalc of >3 wt. %. In contrast, the Miocene Pedro Miguel and Late Basalt Fm...
2017: PloS One
https://www.readbyqxmd.com/read/28489369/qm-mm-investigation-of-substrate-and-product-specificities-of-suv4-20h2-how-does-this-enzyme-generate-di-methylated-h4k20-from-mono-methylated-substrate
#11
Ping Qian, Haobo Guo, Liang Wang, Hong Guo
Protein lysine methyltransferases (PKMTs) catalyze the methylation of lysine residues on histone proteins in the regulation of chromatin structure and gene expression. In contrast to many other PKMTs for which unmodified lysine is the methylation target, the enzymes in the Suv4-20 family are able to generate di-methylated product (H4K20me2) based exclusively on the mono-methylated H4K20 substrate (H4K20me1). The origin of such substrate/product specificity is still not clear. Here molecular dynamics (MD) and free energy (potential of mean force) simulations are undertaken using quantum mechanical/molecular mechanical (QM/MM) potentials to understand the substrate/product specificities of Suv4-20h2, a member of the Suv4-20 family...
May 10, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28484301/comparative-analysis-of-family-medicine-education-and-exams-at-cathedras-of-family-medicine-of-universities-in-southeastern-europe-splitska-inicijativa-sarajevo-2017
#12
Izet Masic, Olivera Batic Mujanovic, Maja Racic, Larisa Gavran, Kosana Stanetic, Merzika Hodzic, Milena Cojic, Ljiljana Cvejanov-Kezunovic, Aleksandar Stepanovic, Katarina Stavrikj, Zaim Jatic, Edita Cerny Obrdalj, Amra Zalihic, Ksenija Tusek-Bunc
Education means: learning, teaching or the process of acquiring skills or behavior modification through various exercises. Traditionally, medical education meant the oral, practical and more passive transferring of knowledge and skills from the educators to students and health professionals. Today the importance of focus on educational quality, particularly in the professions operating in the services required by people is agreed by all involved. The higher educational system shoulders some critical responsibilities in the economic, social, cultural and educational development and growth in the communities...
March 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28482203/transition-from-shod-to-barefoot-alters-dynamic-stability-during-running
#13
Antonis Ekizos, Alessandro Santuz, Adamantios Arampatzis
INTRODUCTION: Barefoot running recently received increased attention, with controversial results regarding its effects on injury risk and performance. Numerous studies examined the kinetic and kinematic changes between the shod and the barefoot condition. Intrinsic parameters such as the local dynamic stability could provide new insight regarding neuromuscular control when immediately transitioning from one running condition to the other. We investigated the local dynamic stability during the change from shod to barefoot running...
April 27, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28480986/the-murine-lens-a-model-to-investigate-in-vivo-epithelial-mesenchymal-transition
#14
REVIEW
Kumi Shirai, Sai-Ichi Tanaka, Frank J Lovicu, Shizuya Saika
Epithelial-mesenchymal transition (EMT) produces myofibroblasts that contribute to the formation of fibrotic tissue with an impairment of tissue homeostasis and functionality. The crystalline lens of the eye is a unique transparent and isolated tissue. The lens vesicle becomes isolated from the surface ectoderm, its cells are all contained as they line the inner surface of the lens capsule. Clinically the formation of fibrotic tissue by the lens epithelial cells causes a type of cataract or opacification and contraction of the lens capsule post-cataract surgery...
May 8, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28480346/measuring-change-in-prostate-size-after-holmium-laser-enucleation-a-prospective-study
#15
Jin Kyu Oh, Kwang-Pil Ko, Seung-June Oh
PURPOSE: To analyze postoperative outcomes of prostate surgery, resected specimen weight is commonly used. The difference between the preoperative calculated transitional zone volume and actual enucleated specimen weight following holmium laser enucleation of the prostate (HoLEP) is reported at over 20%. The reason for this difference is unclear. We assessed the association of volume of the prostatic adenoma with enucleated weight, the volume and calculated volume of the adenoma by pre- and postoperative ultrasonographic measurement...
May 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28475337/structure-dynamics-relation-in-physically-plausible-multi-chromophore-systems
#16
George C Knee, Patrick Rowe, Luke D Smith, Alessandro Troisi, Animesh Datta
We study a large number of physically-plausible arrangements of chromophores, generated via a computational method involving stochastic real-space transformations of a naturally-occurring "reference" structure, illustrating our methodology using the well-studied Fenna-Matthews-Olson complex (FMO). To explore the idea that the natural structure has been tuned for efficient energy transport, we use an atomic transition charge method to calculate the excitonic couplings of each generated structure and a Lindblad master equation to study the quantum transport of an exciton from a "source" to a "drain" chromophore...
May 11, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28475336/on-the-performance-of-td-dft-for-excited-states-of-open-shell-transition-metal-compounds
#17
Bingbing Suo, Kaiyuan Shen, Zhendong Li, Wenjian Liu
Time-dependent density functional theory (TD-DFT) has been very successful in accessing low-lying excited states of closed-shell systems. However, it is much less so for excited states of open-shell systems: unrestricted Kohn-Sham based TD-DFT (U-TD-DFT) often produces physically meaningless excited states due to heavy spin contaminations, whereas restricted Kohn-Sham based TD-DFT often misses those states of lower energies. A much better variant is the explicitly spin-adapted TD-DFT (X-TD-DFT) [J. Chem. Phys...
May 5, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28475322/exploring-the-dynamics-of-propeller-loops-in-human-telomeric-dna-quadruplexes-using-atomistic-simulations
#18
Barira Islam, Petr Stadlbauer, Alejandro Gil-Ley, Guillermo Pérez-Hernández, Shozeb Haider, Stephen Neidle, Giovanni Bussi, Pavel Banas, Michal Otyepka, Jiri Sponer
We have carried out a series of extended unbiased molecular dynamics (MD) simulations (up to 10 μs long, ∼162 μs in total) complemented by replica-exchange with the collective variable tempering (RECT) approach for several human telomeric DNA G-quadruplex (GQ) topologies with TTA propeller loops. We used different AMBER DNA force-field variants and also processed simulations by Markov State Model (MSM) analysis. The slow conformational transitions in the propeller loops took place on a scale of a few μs, emphasizing the need for long simulations in studies of GQ dynamics...
May 18, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28474951/_-36-96-kr_-60-low-z-boundary-of-the-island-of-deformation-at-n-60
#19
J Dudouet, A Lemasson, G Duchêne, M Rejmund, E Clément, C Michelagnoli, F Didierjean, A Korichi, G Maquart, O Stezowski, C Lizarazo, R M Pérez-Vidal, C Andreoiu, G de Angelis, A Astier, C Delafosse, I Deloncle, Z Dombradi, G de France, A Gadea, A Gottardo, B Jacquot, P Jones, T Konstantinopoulos, I Kuti, F Le Blanc, S M Lenzi, G Li, R Lozeva, B Million, D R Napoli, A Navin, C M Petrache, N Pietralla, D Ralet, M Ramdhane, N Redon, C Schmitt, D Sohler, D Verney, D Barrientos, B Birkenbach, I Burrows, L Charles, J Collado, D M Cullen, P Désesquelles, C Domingo Pardo, V González, L Harkness-Brennan, H Hess, D S Judson, M Karolak, W Korten, M Labiche, J Ljungvall, R Menegazzo, D Mengoni, A Pullia, F Recchia, P Reiter, M D Salsac, E Sanchis, Ch Theisen, J J Valiente-Dobón, M Zielińska
Prompt γ-ray spectroscopy of the neutron-rich ^{96}Kr, produced in transfer- and fusion-induced fission reactions, has been performed using the combination of the Advanced Gamma Tracking Array and the VAMOS++ spectrometer. A second excited state, assigned to J^{π}=4^{+}, is observed for the first time, and a previously reported level energy of the first 2^{+} excited state is confirmed. The measured energy ratio R_{4/2}=E(4^{+})/E(2^{+})=2.12(1) indicates that this nucleus does not show a well-developed collectivity contrary to that seen in heavier N=60 isotones...
April 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28473327/autophagy-plays-a-role-in-fstl1-induced-emt-and-airway-remodeling-in-asthma
#20
Tian Liu, Yahui Liu, Marina Miller, Liuzhao Cao, Jiping Zhao, Jinxiang Wu, Junfei Wang, Lin Liu, Shuo Li, Minfang Zou, Jiawei Xu, David H Broide, Liang Dong
Asthma is a chronic disease related to airway hyper-responsiveness and airway remodeling. Airway remodeling is the important reason of refractory asthma and is associated with differentiation of airway epithelia into myofibroblasts via epithelial-mesenchymal transition (EMT) to increase the process of subepithelial fibrosis. There is growing evidence that autophagy modulates remodeling. However, the underlying molecular mechanisms of these effects are still unclear. In this study, we hypothesized that Follistatin-like 1(FSTL1) promotes EMT and airway remodeling by intensifying autophagy...
May 4, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
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