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https://www.readbyqxmd.com/read/28817834/mdm2-promotes-epithelial-mesenchymal-transition-and-metastasis-of-ovarian-cancer-skov3-cells
#1
Ying Chen, Dan-Dan Wang, Ye-Ping Wu, Dan Su, Tian-Yi Zhou, Ren-Hua Gai, Ying-Ying Fu, Lin Zheng, Qiao-Jun He, Hong Zhu, Bo Yang
BACKGROUND: Metastasis accounts for the most lethal reason for the death of ovarian cancer patients, but remains largely untreated. Epithelial-mesenchymal transition (EMT) is critical for the conversion of early-stage ovarian tumours into metastatic malignancies. Thus the exploration of the signalling pathways promoting EMT would open potential opportunities for the treatment of metastatic ovarian cancer. Herein, the putative role of MDM2 in regulating EMT and metastasis of ovarian cancer SKOV3 cells was investigated...
August 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28814044/a-survey-of-stakeholder-perspectives-on-a-proposed-combined-exoskeleton-wheelchair-technology
#2
Tim Bhatnagar, W Ben Mortensen, Johanne Mattie, Jamie Wolff, Claire Parker, Jaimie Borisoff
BACKGROUND: Exoskeleton technology has potential benefits for wheelchair users' health and mobility. However, there are practical barriers to their everyday use as a mobility device. In particular, challenges related to travelling longer distances and transitioning between using a wheelchair and exoskeleton walking may present significant deterrents to regular exoskeleton use. In an effort to remove these barriers, a combined exoskeleton-wheelchair concept ('COMBO') has been proposed, which aims to achieve the benefits of both these mobility technologies...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28805230/the-influence-of-topological-phase-transition-on-the-superfluid-density-of-overdoped-copper-oxides
#3
V R Shaginyan, V A Stephanovich, A Z Msezane, G S Japaridze, K G Popov
We show that a quantum phase transition, generating flat bands and altering Fermi surface topology, is a primary reason for the exotic behavior of the overdoped high-temperature superconductors represented by La2-xSrxCuO4, whose superconductivity features differ from what is predicted by the classical Bardeen-Cooper-Schrieffer theory. This observation can open avenues for chemical preparation of high-Tc materials. We demonstrate that (1) at temperature T = 0, the superfluid density ns turns out to be considerably smaller than the total electron density; (2) the critical temperature Tc is controlled by ns rather than by doping, and is a linear function of the ns; (3) at T > Tc the resistivity ρ(T) varies linearly with temperature, ρ(T) ∝ αT, where α diminishes with Tc → 0, whereas in the normal (non superconducting) region induced by overdoping, Tc = 0, and ρ(T) ∝ T(2)...
August 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28804862/oncological-patients-in-the-intensive-care-unit-prognosis-decision-making-therapies-and-end-of-life-care
#4
Ewelina Biskup, Fengfeng Cai, Marcus Vetter, Stephan Marsch
The effectiveness of intensive care unit (ICU) care for cancer patients remains controversial. Advances in antitumour and supportive care led to major improvements in outcomes of oncological patients in the ICU. Improved cancer therapies and supportive management of organ dysfunctions have contributed to improved survival rates. As a consequence, the number of cancer patients requiring ICU admission is rising. Frequently, cancer patients have a poor performance status and are vulnerable. It is a heterogeneous population, where the nature and curability of the neoplasm and the severity of critical illness cause a plethora of issues about ICU admissions...
August 14, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28802978/gas-phase-hydration-of-glyoxylic-acid-kinetics-and-atmospheric-implications
#5
Ling Liu, Xiuhui Zhang, Zesheng Li, Yunhong Zhang, Maofa Ge
Oxocarboxylic acids are one of the most important organic species found in secondary organic aerosols and can be detected in diverse environments. But the hydration of oxocarboxylic acids in the atmosphere has still not been fully understood. Neglecting the hydration of oxocarboxylic acids in atmospheric models may be one of the most important reasons for the significant discrepancies between field measurements and abundance predictions of atmospheric models for oxocarboxylic acids. In the present paper, glyoxylic acid, as the most abundant oxocarboxylic acids in the atmosphere, has been selected as an example to study whether the hydration process can occur in the atmosphere and what the kinetic process of hydration is...
August 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28802172/interaction-of-phenazinium-based-photosensitizers-with-the-n-and-b-isoforms-of-human-serum-albumin-effect-of-methyl-substitution
#6
Swagata Sen, Riya Sett, Bijan K Paul, Nikhil Guchhait
The present work is focused on exploring the interaction of two phenazinium-based biological photosensitizers, phenosafranin (PSF) and safranin-O (SO), with human serum albumin (HSA), with particular emphasis on the physiologically significant NB conformational transition of the protein on the dye:HSA interaction. In addition, the presence of methyl substitution on the planar phenazinium ring in SO paves way for looking into the effect of simple chemical manipulation (that is, methyl substitution on the dye nucleus) on the dye:protein interaction behavior as a function of various (pH-induced) isoforms of HSA...
August 3, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28801792/electronic-cigarettes-and-awareness-of-their-health-effects
#7
A Daniluk, A Gawlikowska-Sroka, M Stępien-Słodkowska, E Dzięciołowska-Baran, K Michnik
The use of electronic cigarettes or e-cigarettes is strongly on the rise. The literature confirms that in the process of quitting smoking using an electronic device dispensing nicotine should be a transitional stage before the complete cessation of smoking. The aim of the present study was to assess the popularity of e-cigarettes, the underlying reasons for use of such nicotine products, and the level of awareness of health hazards associated with e-cigarettes. The study is of a survey type. The material consisted of data collected from an anonymous survey distributed among 46 female and 23 male users of e-cigarettes in 2015...
August 12, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28800152/prediction-of-the-reduction-potential-in-transition-metal-containing-complexes-how-expensive-for-what-accuracy
#8
Guangchao Liang, Nathan J DeYonker, Xuan Zhao, Charles Edwin Webster
Accurate computationally derived reduction potentials are important for catalyst design. In this contribution, relatively inexpensive density functional theory methods are evaluated for computing reduction potentials of a wide variety of organic, inorganic, and organometallic complexes. Astonishingly, SCRF single points on B3LYP optimized geometries with a reasonably small basis set/ECP combination works quite well--B3LYP with the BS1 [modified-LANL2DZ basis set/ECP (effective core potential) for metals, LANL2DZ(d,p) basis set/LANL2DZ ECP for heavy nonmetals (Si, P, S, Cl, and Br), and 6-31G(d') for other elements (H, C, N, O, and F)] and implicit PCM solvation models, SMD (solvation model based on density) or IEFPCM (integral equation formalism polarizable continuum model with Bondi atomic radii and α = 1...
August 11, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28799671/hydrophobic-flexible-and-lightweight-mxene-foams-for-high-performance-electromagnetic-interference-shielding
#9
Ji Liu, Hao-Bin Zhang, Renhui Sun, Yafeng Liu, Zhangshuo Liu, Aiguo Zhou, Zhong-Zhen Yu
Ultrathin, lightweight, and flexible electromagnetic-interference (EMI) shielding materials are urgently required to manage increasingly serious radiation pollution. 2D transition-metal carbides (MXenes) are considered promising alternatives to graphene for providing excellent EMI-shielding performance due to their outstanding metallic electrical conductivity. However, the hydrophilicity of MXene films may affect their stability and reliability when applied in moist or wet environments. Herein, for the first time, an efficient and facile approach is reported to fabricate freestanding, flexible, and hydrophobic MXene foam with reasonable strength by assembling MXene sheets into films followed by a hydrazine-induced foaming process...
August 11, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28798754/isoprene-responses-and-functions-in-plants-challenged-by-environmental-pressures-associated-to-climate-change
#10
REVIEW
Alessio Fini, Cecilia Brunetti, Francesco Loreto, Mauro Centritto, Francesco Ferrini, Massimiliano Tattini
The functional reasons for isoprene emission are still a matter of hot debate. It was hypothesized that isoprene biosynthesis evolved as an ancestral mechanism in plants adapted to high water availability, to cope with transient and recurrent oxidative stresses during their water-to-land transition. There is a tight association between isoprene emission and species hygrophily, suggesting that isoprene emission may be a favorable trait to cope with occasional exposure to stresses in mesic environments. The suite of morpho-anatomical traits does not allow a conservative water use in hygrophilic mesophytes challenged by the environmental pressures imposed or exacerbated by drought and heat stress...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28798495/the-time-benefits-of-young-adult-home-stayers-in-france-and-italy-a-new-perspective-on-the-transition-to-adulthood
#11
Letizia Mencarini, Ariane Pailhé, Anne Solaz, Maria Letizia Tanturri
This article analyses how two co-residing generations contribute to the housework workload in Italy and France during the early 2000s. It studies the intergenerational exchange of time between young adults and their parents by indirectly comparing the level of domestic comfort enjoyed by young people in the two closely neighbouring countries. A focus on the reasons for staying in the parental home provides an explanation for the tendency of young Italian adults to prolong their stay in the family nest. The results of time-use surveys suggest that young Italians (especially young men) may benefit more than their French counterparts in co-residing with their parents...
2017: Genus
https://www.readbyqxmd.com/read/28797670/the-role-of-alluvial-aquifer-sediments-in-attenuating-a-dissolved-arsenic-plume
#12
Brady A Ziegler, Madeline E Schreiber, Isabelle M Cozzarelli
In a crude-oil-contaminated sandy aquifer at the Bemidji site in northern Minnesota, biodegradation of petroleum hydrocarbons has resulted in release of naturally occurring As to groundwater under Fe-reducing conditions. This study used chemical extractions of aquifer sediments collected in 1993 and 2011-2014 to evaluate the relationship between Fe and As in different redox zones (oxic, methanogenic, Fe-reducing, anoxic-suboxic transition) of the contaminated aquifer over a twenty-year period. Results show that 1) the aquifer has the capacity to naturally attenuate the plume of dissolved As, primarily through sorption; 2) Fe and As are linearly correlated in sediment across all redox zones, and a regression analysis between Fe and As reasonably predicted As concentrations in sediment from 1993 using only Fe concentrations; 3) an As-rich "iron curtain," associated with the anoxic-suboxic transition zone, migrated 30m downgradient between 1993 and 2013 as a result of the hydrocarbon plume evolution; and 4) silt lenses in the aquifer preferentially sequester dissolved As, though As is remobilized into groundwater from sediment after reducing conditions are established...
May 2, 2017: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/28795721/a-cd-ii-based-mof-as-a-photosensitive-schottky-diode-experimental-and-theoretical-studies
#13
Shibashis Halder, Arka Dey, Aradhita Bhattacharjee, Joaquín Ortega-Castro, Antonio Frontera, Partha Pratim Ray, Partha Roy
A Cd(ii) based 2D metal-organic framework (MOF), [Cd(4-bpd)(SCN)2]n (1) where 4-bpd = 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene, has been synthesized and characterized by standard methods including single crystal X-ray diffraction analysis. When it is sandwiched between ITO coated glass and Al, 1 shows interesting conduction properties. The I-V characteristics of the ITO/1/Al configuration measured in the dark and under illumination of incident light exhibit a highly non-linear rectifying behavior, which signifies its Schottky diode character...
August 10, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28793329/using-the-mwc-model-to-describe-heterotropic-interactions-in-hemoglobin
#14
Olga Rapp, Ofer Yifrach
Hemoglobin is a classical model allosteric protein. Research on hemoglobin parallels the development of key cooperativity and allostery concepts, such as the 'all-or-none' Hill formalism, the stepwise Adair binding formulation and the concerted Monod-Wymann-Changuex (MWC) allosteric model. While it is clear that the MWC model adequately describes the cooperative binding of oxygen to hemoglobin, rationalizing the effects of H+, CO2 or organophosphate ligands on hemoglobin-oxygen saturation using the same model remains controversial...
2017: PloS One
https://www.readbyqxmd.com/read/28792480/the-role-of-nutritional-aspects-in-food-allergy-prevention-and-management
#15
REVIEW
Alessandra Mazzocchi, Carina Venter, Kate Maslin, Carlo Agostoni
The prevalence of food allergy in childhood appears to be increasing in both developed and transitional countries. The aim of this paper is to review and summarise key findings in the prevention and management of food allergy, focusing on the role of dietary components and nutritional habits in the development and optimal functioning of the immune system. Essential fatty acids, zinc and vitamin D are likely to enhance the anti-inflammatory and antioxidative barrier and promote immunologic tolerance. Additionally, nutritional components such as pre- and probiotics represent a novel research approach in the attempt to induce a tolerogenic immune environment...
August 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28792170/consensus-on-basal-insulin-in-the-management-of-type-2-diabetes-which-when-and-how
#16
Samit Ghosal, Binayak Sinha, Anirban Majumder, Ashok Kumar Das, Awadhesh Kumar Singh, Biswajit Ghoshdastidar, Debasish Maji, Ghanshyam Goyal, Jagat Jyoti Mukherjee, Kalyan Kumar Gangopadhyay, Mathew John, Sanjay Chatterjee, Shalini Jaggi, Subir Ray, Sujoy Majumdar, Surendra Kumar Sharma
INTRODUCTION: Type 2 diabetes mellitus (T2DM) has attained epidemic proportions and continues to increase despite the availability of a number of oral antidiabetic medications and major advances made in insulin delivery since its discovery nearly a hundred years ago. One, amongst many other reasons responsible for the inability to achieve adequate glycaemic control in a substantial proportion of T2DM patients is the delayed initiation and inappropriate intensification of insulin treatment...
July 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28792079/mentoring-relationship-quality-and-maltreated-children-s-coping
#17
Ashley A Chesmore, Lindsey M Weiler, Heather N Taussig
Coping strategies are believed to protect against the harmful effects of maltreatment on children's psychosocial outcomes. Caregivers are thought to be critical in helping children develop adaptive coping strategies, yet many maltreated children have poor and/or insecure relationships with their parents. A quality relationship with a caring, non-parental adult (e.g., a mentor), however, may be one strategy to promote healthy coping among maltreated children. Children (N = 154) in this study participated in a mentoring and skill-based program for maltreated preadolescents placed in foster care...
August 9, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/28790094/gallstone-ileus-of-the-duodenum-an-unexpected-presentation-of-bouveret-s-syndrome
#18
Neil Tindell, Kayla Holmes, David Marotta
This report describes a patient who presented with a large gallstone obstructing the duodenal bulb, with the chief complaint of acute on chronic abdominal pain. Classically, this is known as Bouveret's syndrome or a gallstone ileus of the duodenum. Our patient's current health status presented a challenge, with the presence of several comorbidities, particularly a large abdominal aortic aneurism. We chose an open procedure for this reason. The stone was removed through a laparotomy, and the cholecystoduodenal fistula that the stone used to pass into the small bowel was repaired...
August 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28772867/influence-of-emulsified-asphalt-on-the-mechanical-property-and-microstructure-of-cement-stabilized-gravel-under-freezing-and-thawing-cycle-conditions
#19
Yiqi Wang, Yiqiu Tan, Meng Guo, Xinglong Wang
Properties of cement-stabilized gravel modified by emulsified asphalt under freezing and thawing cycle conditions were investigated by adjusting the dosage of cement. Mercury intrusion porosimetry (MIP) and Scanning electron microscopy (SEM) were introduced to analyze the influential mechanism. The results indicate that cement emulsified asphalt stabilized gravel with 5 wt % of cement performed well in both mechanics and frost-resistance. Although the addition of emulsified asphalt would lead to a partial decrease of strength, it can extend the process of strength loss and improve the freezing resistance...
May 6, 2017: Materials
https://www.readbyqxmd.com/read/28772673/vo%C3%A2-thermochromic-films-on-quartz-glass-substrate-grown-by-rf-plasma-assisted-oxide-molecular-beam-epitaxy
#20
Dong Zhang, Hong-Jun Sun, Min-Huan Wang, Li-Hua Miao, Hong-Zhu Liu, Yu-Zhi Zhang, Ji-Ming Bian
Vanadium dioxide (VO₂) thermochromic thin films with various thicknesses were grown on quartz glass substrates by radio frequency (RF)-plasma assisted oxide molecular beam epitaxy (O-MBE). The crystal structure, morphology and chemical stoichiometry were investigated systemically by X-ray diffraction (XRD), atomic force microscopy (AFM), Raman spectroscopy and X-ray photoelectron spectroscopy (XPS) analyses. An excellent reversible metal-to-insulator transition (MIT) characteristics accompanied by an abrupt change in both electrical resistivity and optical infrared (IR) transmittance was observed from the optimized sample...
March 19, 2017: Materials
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