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https://www.readbyqxmd.com/read/27922024/improvements-in-the-long-term-outcome-of-crohn-s-disease-over-the-past-two-decades-and-the-relation-to-changes-in-medical-management-results-from-the-population-based-ibdsl-cohort
#1
Steven F G Jeuring, Tim R A van den Heuvel, Limmie Y L Liu, Maurice P Zeegers, Wim H Hameeteman, Mariëlle J L Romberg-Camps, Liekele E Oostenbrug, Ad A M Masclee, Daisy M A E Jonkers, Marieke J Pierik
OBJECTIVES: Medical treatment options and strategies for Crohn's disease (CD) have changed over the past decades. To assess its impact, we studied the evolution of the long-term disease outcome in the Dutch Inflammatory Bowel Disease South Limburg (IBDSL) cohort. METHODS: In total, 1,162 CD patients were included. Three eras were distinguished: 1991-1998 (n=316), 1999-2005 (n=387), and 2006-2011 (n=459), and patients were followed until 2014. Medication exposure and the rates of hospitalization, surgery, and phenotype progression were estimated using Kaplan-Meier survival analyses and compared between eras by multivariable Cox regression models...
December 6, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27918922/removal-of-heavy-metals-from-acid-mine-drainage-using-chicken-eggshells-in-column-mode
#2
Ting Zhang, Zhihong Tu, Guining Lu, Xingchun Duan, Xiaoyun Yi, Chuling Guo, Zhi Dang
Chicken eggshells (ES) as alkaline sorbent were immobilized in a fixed bed to remove typical heavy metals from acid mine drainage (AMD). The obtained breakthrough curves showed that the breakthrough time increased with increasing bed height, but decreased with increasing flow rate and increasing particle size. The Thomas model and bed depth service time model could accurately predict the bed dynamic behavior. At a bed height of 10 cm, a flow rate of 10 mL/min, and with ES particle sizes of 0.18-0.425 mm, for a multi-component heavy metal solution containing Cd(2+), Pb(2+) and Cu(2+), the ES capacities were found to be 1...
December 2, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27917949/intravenous-hmscs-ameliorate-acute-pancreatitis-in-mice-via-secretion-of-tumor-necrosis-factor-%C3%AE-stimulated-gene-protein-6
#3
Zhigang He, Jie Hua, Daohai Qian, Jian Gong, Shengping Lin, Chenglei Xu, Ge Wei, Hongbo Meng, Tingsong Yang, Bo Zhou, Zhenshun Song
The administration of mesenchymal stem cells/multipotent mesenchymal stromal cells (MSCs) to enhance tissue repair is currently undergoing clinical trials. Some studies, including our previous work, have also revealed the beneficial effect of MSCs in severe acute pancreatitis (SAP); however, their mechanisms or mode of action remain controversial. In this study, we demonstrated that intravenously (i.v.)-administered human MSCs (hMSCs) remarkably promoted recovery from experimental SAP without significant engraftment of hMSCs in the damaged pancreas...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27909389/assessing-attention-and-disruptive-behavior-symptoms-in-preschool-age-children-the-utility-of-the-diagnostic-interview-schedule-for-children
#4
Benjamin Rolon-Arroyo, David H Arnold, Elizabeth A Harvey, Nastassja Marshall
Data are presented from two samples of preschool children to evaluate the reliability, concurrent validity, and predictive validity of the ADHD, ODD, and CD sections of the Diagnostic Interview Schedule for Children, Fourth Edition (DISC-IV). Information was obtained from a community sample of 128 children (Mage = 53.16 months; 63 girls) and from a sample of 72 externalizing children (Mage = 45.23 months; 31 girls) plus 25 control children (Mage = 44.51 months; 8 girls). In both studies, the DISC-IV was administered to parents along with parent and teacher behavior rating scales, and teacher rating scales were obtained again later to evaluate the predictive validity of the DISC-IV (after approximately 6 months in Study 1, and 3 years in Study 2)...
January 2016: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/27900058/effect-of-surgical-wound-fluids-after-intraoperative-electron-radiotherapy-on-the-cancer-stem-cell-phenotype-in-a-panel-of-human-breast-cancer-cell-lines
#5
Karolina Zaleska, Wiktoria Maria Suchorska, Anna Przybyła, Dawid Murawa
The wound healing process after surgery alters the area surrounding the original tumor and around the scar, and the modified microenvironment is more favorable for tumor recurrence. Intraoperative radiotherapy (IORT) is one of the more novel strategies in breast cancer (BC) treatment. Irradiation during surgery has effects on the tumor microenvironment, abrogating the proliferative cascade induced by surgical wound healing. The aim of the present study was to determine the effect of surgical wound fluids from IOERT treatment (RT-WF) compared with wound fluids from conservative-breast surgery only (WF) on the cancer stem cell phenotype in a panel of BC cell lines...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27900008/discovery-of-genes-from-feces-correlated-with-colorectal-cancer-progression
#6
Chia-Long Lee, Chi-Jung Huang, Shung-Haur Yang, Chun-Chao Chang, Chi-Cheng Huang, Chih-Cheng Chien, Ruey-Neng Yang
Colorectal cancer (CRC) is considered to develop slowly via a progressive accumulation of genetic mutations. Markers of CRC may serve to provide the basis for decision-making, and may assist in cancer prevention, detection and prognostic prediction. DNA and messenger (m)RNA molecules that are present in human feces faithfully represent CRC manifestations. In the present study, exogenous mouse cells verified the feasibility of total fecal RNA as a marker of CRC. Furthermore, five significant genes encoding solute carrier family 15, member 4 (SLC15A4), cluster of differentiation (CD)44, 3-oxoacid CoA-transferase 1 (OXCT1), placenta-specific 8 (PLAC8) and growth arrest-specific 2 (GAS2), which are differentially expressed in the feces of CRC patients, were verified in different CRC cell lines using quantitative polymerase chain reaction...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27889847/diagnostic-value-of-small-bowel-capsule-endoscopy-in-isolated-ileitis-a-capentry-study
#7
Hyun Seok Lee, Yun Jeong Lim, Ki Nam Shim, Chang Mo Moon, Hyun Joo Song, Jin Oh Kim, Seong Ran Jeon, Dae Young Jung, Ji Hyun Kim, Kyeong Ok Kim, Bo-In Lee
BACKGROUND: Capsule endoscopy (CE) has proven to be highly effective at detecting small bowel lesions, but studies regarding the diagnostic impact of CE on ileitis are rare. AIMS: We evaluated the diagnostic value of small bowel CE for isolated ileitis observed during ileocolonoscopy. METHODS: The CE results in 137 patients initially diagnosed with ileitis without colonic mucosal abnormalities on ileocolonoscopy at one of eight tertiary referral centers between October 2002 and June 2015 were retrospectively analyzed...
November 26, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27885520/the-effect-of-pre-operative-topical-anaesthetic-cream-on-the-ablative-width-and-coagulative-depth-of-ablative-fractional-resurfacing-laser
#8
Preawphan Punyaratabandhu, Rungsima Wanitphakdeedecha, Penvadee Pattanaprichakul, Panitta Sitthinamsuwan, Weeranut Phothong, Sasima Eimpunth, Visnu Lohsiriwat, Woraphong Manuskiatti
Topical anaesthetic cream (TAC) is commonly used as a pre-treatment of ablative fractional resurfacing (AFR) laser. Most of anaesthetic cream contains distilled water as major component. Therefore, pre-operative TAC may interfere the photothermal reaction in the skin treated with fractional carbon-dioxide (FCO2) laser and fractional erbium-doped yttrium aluminium garnet (FEr:YAG) laser. The objective of the study was to compare the ablative width (AW) and coagulative depth (CD) of AFR laser with and without pre-treatment with TAC...
November 24, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27883239/individually-dosed-omalizumab-an-effective-treatment-for-severe-peanut-allergy
#9
J Brandström, M Vetander, G Lilja, S G O Johansson, A-C Sundqvist, F Kalm, C Nilsson, A Nopp
BACKGROUND: Treatment with omalizumab has shown a positive effect on food allergies, but no dosages are established. Basophil allergen threshold sensitivity (CD-sens) can be used to objectively measure omalizumab treatment efficacy and correlates with the outcome of Double Blind Placebo Controlled Food Challenge to peanut. OBJECTIVE: To evaluate if individualized omalizumab treatment monitored by CD-sens could be an effective intervention for suppression of allergic reactions to peanut...
November 24, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27855604/novel-microrna-signature-to-differentiate-ulcerative-colitis-from-crohn-disease-a-genome-wide-study-using-next-generation-sequencing
#10
Jingmei Lin, Xinjun Zhang, Zijin Zhao, Noah Welker, Yong Li, Yunlong Liu, Mary Bronner
BACKGROUND: The diagnosis of ulcerative colitis (UC) or Crohn disease (CD) can be challenging given the overlapping features. Knowledge of microRNAs in IBD has expanded recently and supports that microRNAs play an important role. This study aimed to identify novel microRNA biomarkers through comprehensive genome-wide sequencing to distinguish UC from CD. DESIGN: Illumina next generation sequencing was performed on nondysplastic fresh-frozen colonic mucosa of the distal-most colectomy from 19 patients (10 UC and 9 CD) and 18 patients with diverticular disease serving as controls...
November 17, 2016: MicroRNA
https://www.readbyqxmd.com/read/27833391/systematic-review-safety-of-balloon-assisted-enteroscopy-in-crohn-s-disease
#11
Ahilan Arulanandan, Parambir S Dulai, Siddharth Singh, William J Sandborn, Denise Kalmaz
AIM: To determine the overall and comparative risk of procedure related perforation of balloon assisted enteroscopy (BAE) in Crohn's disease (CD). METHODS: Systematic review (PROSPERO #CRD42015016381) of studies reporting on CD patients undergoing BAE. Seventy-three studies reporting on 1812 patients undergoing 2340 BAEs were included. Primary outcome of interest was the overall and comparative risk of procedure related perforation of diagnostic BAE in CD. Secondary outcomes of interest were risk of procedure related perforation of diagnostic double balloon enteroscopy (DBE), risk of procedure related perforation of therapeutic BAE, efficacy of stricture dilation, and clinical utility of endoscopically assessing small bowel disease activity...
October 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27818071/evaluating-an-anaerobic-digestion-ad-feedstock-derived-from-a-novel-non-source-segregated-municipal-solid-waste-msw-product
#12
L I Blake, F A Halim, C Gray, R Mair, D A C Manning, P Sallis, H Hutchinson, N D Gray
In many nations industrial scale AD of non-agricultural waste materials (such as MSW) has not yet reached its full potential, often constrained by the lack of secure, inexpensive, high quality AD feedstocks, and markets for the resulting digestate material. We tested the output material of a high throughput novel industrial process to define its potential as an AD feedstock (based on quality and consistency). This process, designed to circumvent the constraints of source segregation while still generating segregated waste streams, resulted in the production of a temporally homogenous fibrous material with: an average moisture content of 44...
November 3, 2016: Waste Management
https://www.readbyqxmd.com/read/27815353/estimates-of-disease-course-in-inflammatory-bowel-disease-using-administrative-data-a-population-level-study
#13
Dessalegn Y Melesse, Lisa M Lix, Zoann Nugent, Laura E Targownik, Harminder Singh, James F Blanchard, Charles N Bernstein
OBJECTIVE: To develop a predictive model of disease course in inflammatory bowel disease (IBD) using health care utilization measures from administrative health data, and to apply this model to estimate disease course at a population level over time. METHODS: Study participants were IBD patients who were prospectively followed for a one-year period between 2009 and 2010 in a Canadian clinic setting to assess their IBD disease course (i.e., remission, mild, moderate, severe)...
November 4, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/27801490/radiation-exposure-in-crohn-s-disease-patients
#14
Houda Bousorra, Asma Labidi, Monia Fekih, Nadia Ben Mustapha, Meriem Serghini, Jalel Boubaker, Azza Filali
Introudction Crohn's disease (CD) is a lifelong condition. Multiple imaging investigations are often performed during follow-up. This could cause overexposure to radiation. The aim of our study was to determine mean radiation dose in patients  with  at least a 5-year course of CD and to determine possible risk factors associated with exposure to high doses of radiation. Methods We conducted a retrospective study including patients whose CD was diagnosed between 1998 and 2005. Epidemiologic features of patients, characteristics of the disease,  types of imaging investigations that were performed during follow-up and cumulative radiation effective dose were determined...
May 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/27785086/systematic-review-treatment-pattern-and-clinical-effectiveness-and-safety-of-pharmaceutical-therapies-for-crohn-s-disease-in-europe
#15
REVIEW
Filippo Lelli, Solomon Nuhoho, Xin Ying Lee, Weiwei Xu
BACKGROUND: Although many clinical trials have been conducted in treatments of Crohn's disease (CD), whether the trial results were representative of daily practice needs to be supported by studies conducted in real-world settings. AIM: This study aims to identify how CD is treated and what are the clinical effectiveness and safety of the pharmaceutical therapies of CD in real-world settings. METHODS: A systematic literature review was conducted based on Medline(®), Embase(®), and Cochrane...
2016: Clinical and Experimental Gastroenterology
https://www.readbyqxmd.com/read/27779682/the-hedgehog-signaling-pathway-is-associated-with-poor-prognosis-in-breast-cancer-patients-with-the-cd44-cd24%C3%A2-phenotype
#16
Haishan Zhao, Hongtao Tang, Qinghuan Xiao, Miao He, Lin Zhao, Yingzi Fu, Huizhe Wu, Zhaojin Yu, Qian Jiang, Yuanyuan Yan, Feng Jin, Minjie Wei
Cancer stem cells (CSCs) have been suggested to serve an important role in tumor recurrence and metastasis in breast cancer. The hedgehog (Hh) signaling pathway is essential for the maintenance of breast CSCs. The present study used immunohistochemistry to investigate the expression of Patched (PTCH) and Gli1, which are the main components of the Hh signaling pathway, as well as the expression of cluster of differentiation (CD)44/CD24, which are markers for breast CSCs, in 266 patients with breast cancer. The combined expression of PTCH and Gli1 was significantly associated with larger tumors (>2...
October 19, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27778365/moderate-prenatal-cadmium-exposure-and-adverse-birth-outcomes-a-role-for-sex-specific-differences
#17
Caroline M Taylor, Jean Golding, Alan M Emond
BACKGROUND/AIM: Studies on the effects of moderate prenatal exposure to cadmium (Cd) on birth outcomes have been contradictory and it has been suggested that effects may be partly masked by sex-specific effects. Our aim was to examine the association of Cd exposure in a large group of pregnant women with birth outcomes in the whole group of participants and by sex. METHODS: Pregnant women were enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC)...
November 2016: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/27778267/arsenic-cadmium-lead-and-mercury-levels-in-blood-of-finnish-adults-and-their-relation-to-diet-lifestyle-habits-and-sociodemographic-variables
#18
Khaled Abass, Markku Koiranen, Darja Mazej, Janja Snoj Tratnik, Milena Horvat, Jukka Hakkola, Marjo-Riitta Järvelin, Arja Rautio
The Northern Finland Birth Cohort program (NFBC) is the epidemiological and longitudinal prospective general population research program, which was established to promote health and wellbeing of the population in northern Finland. The aim of present study, as a part of the NFBC program, was to analyze the blood levels of arsenic (B-As), cadmium (B-Cd), lead (B-Pb), total mercury (B-Hg) and selenium (B-Se); to compare these levels with threshold limits; to study sociodemographic factors; and to correlate these levels with calcium and haemoglobin...
October 24, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27776228/chemical-composition-and-bioaccumulation-ability-of-boletus-badius-fr-fr-collected-in-western-poland
#19
Natalia Proskura, Joanna Podlasińska, Lidia Skopicz-Radkiewicz
: The aim of the study was to determine content of 17 elements (Co, Cd, Cu, Cr, Ni, Pb, Zn, Mn, Fe, Mg, Na, Ca, K, N, C, S and P) and their bioaccumulation factors (BCF) in bay bolete (Boletus badius (Fr.) Fr.) fruiting bodies (caps and stalks) and underneath soil samples collected from forest sites in lubuskie voivodeship in Poland. Forty-eight samples of Boletus badius (Fr.) Fr. fruiting bodies and the same number of underneath soil substrate samples were collected in forest sites of Sulęcin Forest District in western Poland...
October 21, 2016: Chemosphere
https://www.readbyqxmd.com/read/27770708/environmental-and-dietary-exposure-of-young-children-to-inorganic-trace-elements
#20
Philippe Glorennec, Jean-Paul Lucas, Anne-Camille Mercat, Alain-Claude Roudot, Barbara Le Bot
Children are exposed to toxic metals and metalloids via their diet and environment. Our objective was to assess the aggregate chronic exposure of children aged 3-6years, living in France, to As, Cd, Cr, Cu, Mn, Pb, Sb, Sr, and V present in diet, tap water, air, soil and floor dust in the years 2007-2009. Dietary data came from the French Total Diet Study, while concentrations in residential tap water, soil and indoor floor dust came from the 'Plomb-Habitat' nationwide representative survey on children's lead exposure at home...
October 19, 2016: Environment International
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