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https://www.readbyqxmd.com/read/28801416/outcome-of-revascularisation-in-stable-coronary-artery-disease-without-ischaemia-a-danish-registry-based-follow-up-study
#1
Jane Angel Simonsen, Hans Mickley, Allan Johansen, Søren Hess, Anders Thomassen, Oke Gerke, Lisette O Jensen, Jesper Hallas, Werner Vach, Poul F Hoilund-Carlsen
OBJECTIVES: In stable coronary artery disease (CAD), coronary revascularisation may reduce mortality of patients with a certain amount of left ventricular myocardial ischaemia. However, revascularisation does not always follow the guidance suggested by ischaemia testing. We compared outcomes in patients without ischaemia who had either revascularisation or medical treatment. DESIGN AND POPULATION: Based on registries, 1327 consecutive patients with normal myocardial perfusion scintigraphy (MPS) and 278 with fixed perfusion defects were followed for a median of 6...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28757423/solid-solid-crosslinking-of-carboxymethyl-cellulose-nanolayer-on-titanium-oxide-nanoparticles-as-a-novel-biocomposite-for-efficient-removal-of-toxic-heavy-metals-from-water
#2
Mohamed E Mahmoud, Azza E H Abdou, Mostafa E Sobhy, Nesma A Fekry
Nano titanium oxide (Nano-TiO2) was used in this work as a solid support to solid-solid immobilize carboxymethyl cellulose via glutaraldehyde as an efficient cross linking reagent to produce a novel nanosized biocomposite (Nano-TiO2-glu-CMC). The synthesized materials were characterized by FT-IR to confirm crosslinking reaction between the two species as well as by HR-TEM, SEM, TGA and surface area analysis. The particle size was found to correspond to 22.2-44.4nm for Nano-TiO2-glu-CMC. The designed nanosized biocomposite was used and compared with Nano-TiO2 for separation and extraction of heavy metal ions such as Cd(II), Pb(II) and Hg(II) from aqueous solution by using batch experiment and microcolumn technique...
July 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28750341/the-enzyme-sensitive-release-of-prodigiosin-grafted-%C3%AE-cyclodextrin-and-chitosan-magnetic-nanoparticles-as-an-anticancer-drug-delivery-system-synthesis-characterization-and-cytotoxicity-studies
#3
Banafsheh Rastegari, Hamid Reza Karbalaei-Heidari, Sedigheh Zeinali, Heather Sheardown
In present investigation, two glucose based smart tumor-targeted drug delivery systems coupled with enzyme-sensitive release strategy are introduced. Magnetic nanoparticles (Fe3O4) were grafted with carboxymethyl chitosan (CS) and β-cyclodextrin (β-CD) as carriers. Prodigiosin (PG) was used as the model anti-tumor drug, targeting aggressive tumor cells. The morphology, properties and composition and grafting process were characterized by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR), vibration sample magnetometer (VSM), X-ray diffraction (XRD) analysis...
July 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28747006/biotoxic-impact-of-heavy-metals-on-growth-oxidative-stress-and-morphological-changes-in-root-structure-of-wheat-triticum-aestivum-l-and-stress-alleviation-by-pseudomonas-aeruginosa-strain-cpsb1
#4
Asfa Rizvi, Mohd Saghir Khan
Rapid industrialization and uncontrolled metal discharge into environment is a global concern for crop production. Metal tolerant bacterium isolated from chilli rhizosphere was identified as Pseudomonas aeruginosa by 16S rDNA sequence analysis. Pseudomonas aeruginosa tolerated high concentrations of Cu (1400 μg ml(-1)), Cd (1000 μg ml(-1)) and Cr (1000 μg ml(-1)). Pseudomonas aeruginosa CPSB1 produced multiple plant growth promoting biomolecules in the presence and absence of metals. Strain CPSB1 solubilized P at 400 μg ml(-1) of Cd, Cr and Cu...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28741684/how-does-mandibular-bone-atrophy-influence-the-masticatory-function-ohrqol-and-satisfaction-in-overdenture-wearers-clinical-results-until-1-year-post-loading
#5
Raissa Micaella Marcello-Machado, Fernanda Faot, Alessandra Julie Schuster, Amália Machado Bielemann, Otacílio Luiz Chagas Júnior, Altair Antoninha Del Bel Cury
This longitudinal clinical study investigated the differences in the masticatory function (MF), satisfaction and oral health related quality of life (OHRQoL) between atrophic patients (AP) and non-atrophic patients (NAP) before and after rehabilitation with mandibular overdenture (MO). Twenty-six complete denture (CD) wearers were categorized into two groups, according to the mandibular bone atrophy (MBA) degree. MF was evaluated before and after 1, 3, 6 and 12 months of the MO loading via 2 standardized tests: i) MP, masticatory performance (MP_X50, MPB, ME 5...
July 25, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28739103/contamination-assessment-of-mercury-lead-cadmium-and-arsenic-in-surface-sediments-of-chabahar-bay
#6
Neda Molamohyeddin, Hossein Ghafourian, Seyed Mohamadtaghi Sadatipour
This study aimed to investigate heavy metals content of mercury (Hg), lead (Pb), cadmium (Cd) and arsenic (As) in surface sediments of Chabahar Bay. Sediment samples were taken from 13 stations and then analyzed. The concentration of Hg, Pb, Cd and As ranged between 0.06 and 0.14ppm, 8 and 23ppm, 0.05 and 0.9ppm and 5 and 22ppm, respectively. Arsenic content was more than ERL at some stations. Statistical analyses indicated critical importance of organic matter and mud in metal dispersion. Also, positive correlation of Al with Pb, Hg and Cd probably implies their terrestrial origination...
July 21, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28731836/mortality-rate-and-antibiotic-resistance-in-complicated-diverticulitis-report-of-272-consecutive-patients-worldwide-a-prospective-cohort-study
#7
Federico Coccolini, Mattia Trevisan, Giulia Montori, Massimo Sartelli, Fausto Catena, Marco Ceresoli, Antonio Costanzo, Arianna Heyer, Luca Ansaloni
BACKGROUND: Complicated diverticulitis (CD) is a common problem for surgeons. In treating it, as a general principle, every verified source of infection should be controlled. Supplementary antimicrobial management involves a delicate balance of optimizing empirical therapy while reducing unnecessary antibiotic use. The necessity to know the most frequent infecting pathogens and their spectra of resistance is becoming pivotal. The aim of this study was to determine the microbiologic profile of complicated intra-abdominal infections (IAIs) secondary to CD, to analyze the role of empirical antimicrobial therapy, and to describe the clinical aspects of CD worldwide...
July 21, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28726073/investigation-of-heavy-metal-level-and-mineral-nutrient-status-in-widely-used-medicinal-plants-leaves-in-turkey-insights-into-health-implications
#8
Ibrahim Ilker Ozyigit, Bahattin Yalcin, Senay Turan, Ibrahim Adnan Saracoglu, Sedat Karadeniz, Ibrahim Ertugrul Yalcin, Goksel Demir
The use of plants in treatments has been as old as humanity and it has preserved its popularity for centuries til now because of their availability, affordability and safeness. However, despite their widespread use, safety and quality issues have been major concerns in the world due to industrial- and anthropogenic-based heavy metal contamination risks. Thus, this study was attempted to analyze the heavy metal levels and mineral nutrient status of widely used medicinal plants in Turkey to have insights about their health implications on humans...
July 19, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28718293/functional-design-of-dielectric-metal-dielectric-based-thin-film-encapsulation-with-heat-transfer-and-flexibility-for-flexible-displays
#9
Jeong Hyun Kwon, Seungyeop Choi, Yongmin Jeon, Hyuncheol Kim, Ki Soo Chang, Kyung Cheol Choi
In this study, a new and efficient dielectric-metal-dielectric-based thin-film encapsulation (DMD-TFE) with an inserted Ag thin film is proposed to guarantee the reliability of flexible displays by improving the barrier properties, mechanical flexibility, and heat dissipation, which are considered to be essential requirements for organic light-emitting diode (OLED) encapsulation. The DMD-TFE, which is composed of Al2O3, Ag, and a silica nanoparticle-embedded sol-gel hybrid nanocomposite, shows a water vapor transmission rate of 8...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28695733/efficient-all-solution-processed-quantum-dot-light-emitting-diodes-based-on-inkjet-printing-technique
#10
Yang Liu, Fushan Li, Zhongwei Xu, Congxiu Zheng, Tailiang Guo, Xiangwei Xie, Lei Qian, Dong Fu, Xiaolin Yan
Quantum dot light emitting diodes (QLEDs) are increasingly attractive owing to their compatibility with the inkjet printing process and potential application in low-cost large-area full-color pixelated display. The strategy for controlling the morphology of the quantum dot layer is definitely critical for realizing all-solution processed QLEDs with high performance, which certainly requires in-depth thinking regarding the design of ink composition and their optimization in the printing process. Herein, by carefully controlling the quantum dot ink composition and physicochemical properties, we demonstrate that the viscosity, contact angle, and the three-phase contact line moving would affect the final morphology of the quantum dot film formed by inkjet printing...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28694133/ectopic-pregnancy-in-women-with-inflammatory-bowel-disease-a-22-year-nationwide-cohort-study
#11
Punyanganie S de Silva, Helene H Hansen, Sonja Wehberg, Sonia Friedman, Bente M Nørgård
BACKGROUND & AIMS: Data on early adverse pregnancy outcomes in inflammatory bowel disease (IBD) such as ectopic pregnancy (EP) remain limited. We assessed the risk of EP in pregnancies of Danish women with IBD compared to all other Danish women over a 22-year period. In addition, we examined the disease-specific risk of EP in pregnancies of women with ulcerative colitis (UC) or Crohn's disease (CD) who underwent IBD-related surgical procedures. METHODS: We obtained nationwide data in all women of child-bearing age who had at least one pregnancy resulting in either an EP, hydatiform mole, induced abortion, miscarriage, or live birth from January 1994 through 2015...
July 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28693269/significance-of-e-cadherin-and-cd44-expression-in-patients-with-unresectable-metastatic-colorectal-cancer
#12
Yasuhito Iseki, Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tetsuro Ikeya, Kosei Hirakawa
The loss of adhesion molecules is reported to be associated with tumor invasion and metastasis in numerous types of cancer. Epithelial (E)-cadherin is an important molecule for cell-to-cell adhesion, while cluster of differentiation (CD)44 is an important molecule for cell-to-extracellular matrix adhesion. The focus of the present study was to evaluate the significance of the expression of E-cadherin and CD44 in patients with the unresectable metastatic colorectal cancer (CRC) who are undergoing palliative chemotherapy...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693201/s100p-is-associated-with-proliferation-and-migration-in-nasopharyngeal-carcinoma
#13
Yueyang Liu, Chengyu Wang, Xiaodong Shan, Jian Wu, Huanhai Liu, Haibin Liu, Jiping Zhang, Weihua Xu, Zhirong Sha, Jin He, Jingping Fan
In the present study, the function of S100 calcium binding protein P (S100P) in the C666-1 nasopharyngeal carcinoma (NPC) cell line was examined. The levels of S100P protein in NPC tissues were analyzed using immunohistochemistry, and small interfering RNA silenced S100P expression in C666-1 cells. Subsequently, cell proliferation, colony formation, migration and wound-healing assays were performed in order to assess whether the knockdown of S100P was able to influence the biological behavior of C666-1 cells...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693187/salinomycin-inhibits-canine-mammary-carcinoma-in-vitro-by-targeting-cancer-stem-cells
#14
Hongchao Du, Bin Zhou, Hong Zhang, Yipeng Jin, Di Zhang, Degui Lin
Salinomycin (SAL), a polyether ionophore antibiotic, has been demonstrated to selectively kill cancer stem cells (CSCs) in various types of human tumor. The aim of the present study was to investigate the effects of SAL on canine mammary CSCs. CSCs in canine mammary carcinoma cell lines (CMT7364 and CIPp) were identified using a sphere formation assay and flow cytometry. The chemoresistance, invasive potential and expression of stem cell-associated proteins of these spheres was then analyzed. This demonstrated that the spheres exhibited characteristics of CSCs, including a cluster of differentiation (CD)44(+)/CD24(-/low) phenotype, upregulation of Wnt/β-catenin signaling pathway-associated proteins and chemoresistance...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693170/prognostic-significance-of-abcb1-in-stage-i-lung-adenocarcinoma
#15
Fenfei Zou, Masahiro Seike, Rintaro Noro, Shinobu Kunugi, Kaoru Kubota, Akihiko Gemma
Cancer stem cell (CSC) properties have been recently proposed to explain tumor carcinogenesis and multidrug resistance in several human cancers, including non-small cell lung cancer (NSCLC). The present study examined the protein expression of three CSC-associated markers, namely ATP binding cassette subfamily B member 1 (ABCB1), aldehyde dehydrogenase 1 family member A1 (ALDH1A1) and cluster of differentiation (CD) 44, by immunohistochemistry in 194 NSCLC patients who underwent complete resection of NSCLC tumors...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28687159/15-years-of-the-histopathological-synovitis-score-further-development-and-review-a-diagnostic-score-for-rheumatology-and-orthopaedics
#16
REVIEW
V Krenn, G Perino, W Rüther, V T Krenn, M Huber, T Hügle, A Najm, S Müller, F Boettner, F Pessler, W Waldstein, J Kriegsmann, R Casadonte, T Häupl, S Wienert, M G Krukemeyer, S Sesselmann, S Sunitsch, R Tikhilov, L Morawietz
The histopathological synovitis score evaluates the immunological and inflammatory changes of synovitis in a graduated manner generally customary for diagnostic histopathological scores. The score results from semiquantitative evaluation of the width of the synovial surface cell layer, the cell density of the stroma and the density of the inflammatory infiltration into 4 semiquantitative levels (normal 0, mild 1, moderate 2, severe 3). The addition of these values results in a final score of 0-9 out of 9. On the basis of this summation the condition is divided into low-grade synovitis and high-grade synovitis: A synovitis score of 1 to≤4 is called low-grade synovitis (arthrosis-associated/OA synovitis, posttraumatic synovitis, meniscopathy-associated synovitis and synovitis with haemochromatosis)...
August 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28685635/effect-of-clinical-and-laboratory-parameters-on-quality-of-life-in-celiac-patients-using-celiac-disease-specific-quality-of-life-scores
#17
Jungmin Lee, Kofi Clarke
OBJECTIVES: Health-related quality of life (HR-QOL) in patients with celiac disease is reduced compared to the general population. We investigated the association between HR-QOL and clinical, laboratory findings using the previously validated CD-QOL (celiac disease-specific quality of life) instrument in patients with celiac disease. To our knowledge, no study has previously explored the relationship between HR-QOL and clinical, laboratory parameters in celiac patients. MATERIALS AND METHODS: Patients who received care at the Allegheny Health Network Celiac Center, Pittsburgh, PA were asked to complete the CD-QOL questionnaire...
July 7, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28685527/elevated-levels-of-il-2-and-il-21-produced-by-cd4-t-cells-in-inflammatory-bowel-disease
#18
S Ebrahimpour, M Shahbazi, A Khalili, M T Tahoori, A Zavaran Hosseini, A Amari, B Aghili, S Abediankenari, H Mohammadizad, M Mohammadnia-Afrouzi
CD4+ T cells are considered as a subset of cells that play a pivotal role in the development of inflammatory bowel disease (IBD). The aim of this study was to assess the levels of interleukin (IL)-2, IL-21 and their receptors produced by CD4+ T cells in patients with inflammatory bowel disease. Thirty-two patients with ulcerative colitis (UC) and mean age of 37.93±10.37 years, as well as 22 patients with Crohn’s disease (CD) and mean age of 37.04±10.44 years, were studied. The healthy controls (HC) included 31 subjects with a mean age of 36...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28685064/identification-of-rhodamine-123-positive-stem-cell-subpopulations-in-canine-hepatocellular-carcinoma-cells
#19
Harumichi Itoh, Shimpei Nishikawa, Tomoya Haraguchi, Yu Arikawa, Masato Hiyama, Toshie Iseri, Yoshiki Itoh, Munekazu Nakaichi, Yasuho Taura, Kenji Tani, Kazuhito Itamoto
The majority of cases of chemotherapy for hepatocellular carcinoma (HCC) are not effective in human or veterinary medicine due to resistance against anticancer agents. In human medicine, hepatocellular carcinoma stem cells (HCSCs) were recently identified as cytokeratin 19 (CK19)-, cluster of differentiation (CD)-44-, and CD133-positive. However, there are few previous reports regarding canine HCSC (cHCSC). Additionally, to the best of our knowledge, the chemoresistance against anticancer agents of these cHCSCs has not been investigated...
July 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28677766/human-decidua-mesenchymal-stem-cells-regulate-decidual-natural-killer-cell-function-via-interactions-between-collagen-and-leukocyte%C3%A2-associated-immunoglobulin%C3%A2-like-receptor-1
#20
Qiang Fu, Xuejing Man, Min Yu, Yongli Chu, Xiying Luan, Hailan Piao, Jiangnan Xue, Changzhu Jin
The development of maternal tolerance to the fetal allograft in critical for the maintenance of the pregnancy, and it is accompanied by the development of a special decidual natural killer (dNK) cell tolerance phenotype. To understand the factors that influence dNK cells during early pregnancy, the present study aimed to identify mesenchymal stem cells (MSCs) from human first‑trimester deciduas, termed decidual MSCs (DMSCs), and to investigate the effect of DMSCs on the regulation of dNK cells via collagen...
September 2017: Molecular Medicine Reports
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