keyword
MENU ▼
Read by QxMD icon Read
search

CD 44

keyword
https://www.readbyqxmd.com/read/28089682/prevalence-and-risk-of-inflammatory-bowel-disease-in-patients-with-hidradenitis-suppurativa
#1
Alexander Egeberg, Gregor B E Jemec, Alexa B Kimball, Hervé Bachelez, Gunnar H Gislason, Jacob P Thyssen, Lotus Mallbris
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. In small studies, inflammatory bowel disease (IBD) has been associated with increased prevalence of HS, but data on the concurrence of IBD in patients with HS is limited. We therefore investigated the prevalence and risk of IBD in patients with HS compared with the general population. The study linked all Danish individuals ≥18 years in nationwide registers. Adjusted odds ratios (OR) and adjusted hazard ratios (HRs) were estimated by logistic regression and Cox regression, respectively...
January 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28072425/direct-microscale-measurement-of-mouse-oocyte-membrane-permeability-to-water-and-ethylene-glycol-at-subzero-temperatures-using-cryomicroscopy
#2
X Han
:   BACKGROUND: Investigation of cell osmotic behavior at subzero temperatures is of critical importance to the optimization of cooling procedures for cryopreservation. Based on established thermodynamic models, plasma membrane permeability coefficients for water and cryoprotectant agent (CPA) (Lcpa, Pp) and their activation energies (Ea(Lp), Ea(Pcpa)) are essential to predict the change of cell volume and composition of intracellular solutions corresponding to different cooling procedures...
November 2016: Cryo Letters
https://www.readbyqxmd.com/read/28071654/responsiveness-of-endoscopic-indices-of-disease-activity-for-crohn-s-disease
#3
Reena Khanna, GuangYong Zou, Larry Stitt, Brian G Feagan, William J Sandborn, Paul Rutgeerts, John W D McDonald, Elena Dubcenco, Ronald Fogel, Remo Panaccione, Vipul Jairath, Sigrid Nelson, Lisa M Shackelton, Bidan Huang, Qian Zhou, Anne M Robinson, Barrett G Levesque, Geert D'Haens
OBJECTIVES: The Crohn's Disease Endoscopic Index of Severity (CDEIS) and the Simple Endoscopic Score for Crohn's Disease (SES-CD) are commonly used to assess Crohn's disease (CD) activity; however neither instrument is fully validated. We evaluated the responsiveness to change of the SES-CD and CDEIS using data from a trial of adalimumab, a drug therapy of known efficacy. METHODS: Paired video recordings (N=112) of colonoscopies (baseline and week 8-12) obtained from patients with CD who participated in a trial of adalimumab therapy were reviewed in random order, in duplicate, by four central readers (56 pairs of videos by 2 groups of readers)...
January 10, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28040992/tweak-is-not-elevated-in-patients-with-newly-diagnosed-inflammatory-bowel-disease
#4
Tore Grimstad, Inger Marie Skoie, Jessica Doerner, Kjetil Isaksen, Lars Karlsen, Lars Aabakken, Roald Omdal, Chaim Putterman
OBJECTIVE: Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) may be involved in the pathogenesis of inflammatory bowel disease. The aim was to investigate if TWEAK may reflect disease activity in inflammatory bowel disease. MATERIALS AND METHODS: In this cohort study, 139 consecutive patients with newly diagnosed and previously untreated inflammatory bowel disease - 95 with ulcerative colitis (UC) and 44 with Crohn's disease (CD) - underwent colonoscopy...
December 31, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28025307/five-year-safety-data-from-encore-a-european-observational-safety-registry-for-adults-with-crohn-s-disease-treated-with-infliximab-remicade%C3%A2-or-conventional-therapy
#5
Geert D'Haens, Walter Reinisch, Jean-Frederic Colombel, Julian Panes, Subrata Ghosh, Cosimo Prantera, Stefan Lindgren, Daniel W Hommes, Zhiping Huang, Judith Boice, Susan Huyck, Freddy Cornillie
BACKGROUND AND AIMS: The ENCORE registry aimed at comparing the long-term safety of Crohn's disease [CD] treatment with infliximab [Remicade(®)] and with conventional therapies in real-world clinical practice. METHODS: The 5-year, prospective, observational ENCORE registry followed patients with CD in nine European countries, who received treatment with infliximab, conventional therapies, or switched to infliximab from conventional therapy. Adverse events [AEs] in pre-specified categories and serious AEs were recorded at least every 6 months of the 5-year observation period...
December 26, 2016: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28008999/genetic-architecture-differences-between-pediatric-and-adult-onset-inflammatory-bowel-diseases-in-the-polish-population
#6
Jerzy Ostrowski, Agnieszka Paziewska, Izabella Lazowska, Filip Ambrozkiewicz, Krzysztof Goryca, Maria Kulecka, Tomasz Rawa, Jakub Karczmarski, Michalina Dabrowska, Natalia Zeber-Lubecka, Roman Tomecki, Anna Kluska, Aneta Balabas, Magdalena Piatkowska, Katarzyna Paczkowska, Jaroslaw Kierkus, Piotr Socha, Michal Lodyga, Grazyna Rydzewska, Maria Klopocka, Grazyna Mierzwa, Barbara Iwanczak, Elzbieta Krzesiek, Katarzyna Bak-Drabik, Jaroslaw Walkowiak, Beata Klincewicz, Piotr Radwan, Urszula Grzybowska-Chlebowczyk, Piotr Landowski, Agnieszka Jankowska, Bartosz Korczowski, Teresa Starzynska, Piotr Albrecht, Michal Mikula
Most inflammatory bowel diseases (IBDs) are classic complex disorders represented by common alleles. Here we aimed to define the genetic architecture of pediatric and adult-onset IBDs for the Polish population. A total of 1495 patients were recruited, including 761 patients with Crohn's disease (CD; 424 pediatric), 734 patients with ulcerative colitis (UC; 390 pediatric), and 934 healthy controls. Allelotyping employed a pooled-DNA genome-wide association study (GWAS) and was validated by individual genotyping...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28003811/identification-and-characterization-of-a-novel-association-between-dietary-potassium-and-risk-of-crohn-s-disease-and-ulcerative-colitis
#7
Hamed Khalili, Sakshi Malik, Ashwin N Ananthakrishnan, John J Garber, Leslie M Higuchi, Amit Joshi, Joanna Peloquin, James M Richter, Kathleen O Stewart, Gary C Curhan, Amit Awasthi, Vijay Yajnik, Andrew T Chan
BACKGROUND: Recent animal studies have identified that dietary salt intake may modify the risk and progression of autoimmune disorders through modulation of the IL-23/TH17 pathway, which is critical in the pathogenesis of ulcerative colitis (UC) and Crohn's disease (CD). METHODS: We conducted a prospective study of U.S. women enrolled in the Nurses' Health Study (NHS) and NHSII who provided detailed and validated information on diet and lifestyle beginning in 1984 in NHS and 1991 in NHSII...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27986584/bariatric-surgery-in-morbidly-obese-patients-with-inflammatory-bowel-disease-a-systematic-review
#8
Saeed Shoar, Sayed Shahabuddin Hoseini, Mohammad Naderan, Habibollah Mahmoodzadeh, Fung Ying Man, Nasrin Shoar, Motahar Hosseini, Shahram Bagheri-Hariri
BACKGROUNDS: With increased prevalence of obesity, the number of inflammatory bowel disease (IBD) patients suffering from morbid obesity has raised. It is not clear yet if bariatric surgery is a safe and effective option in this population. OBJECTIVES: Our systematic review aims to summarize the available literature on the safety and efficacy of bariatric surgery in morbidly obese patients with IBD. SETTING: University hospital, Iran. METHODS: A PubMed/MEDLINE search was performed to identify studies reporting the outcome of morbidly obese IBD patients...
October 25, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27982201/incidence-and-prevalence-of-clinically-relevant-pituitary-adenomas-retrospective-cohort-study-in-a-health-management-organization-in-buenos-aires-argentina
#9
Patricia Fainstein Day, Monica Graciela Loto, Mariela Glerean, María Fabiana Russo Picasso, Soledad Lovazzano, Diego Hernán Giunta
Objectives: The main purpose of this study was to estimate the incidence rate and prevalence of clinically relevant pituitary adenomas (PAs) within the Hospital Italiano Medical Care Program (HIMCP), a well-defined population of 150,000 members living in the urban and suburban area of the city of Buenos Aires. We defined clinically relevant PAs as those associated with endocrine dysfunction and/or mass effect. Subjects and methods: A retrospective open cohort study was conducted, including all members of the HIMCP over 18 years old, with active memberships during the period of the study, from January 1st 2003, to January 1, 2014...
November 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27979181/effect-of-metal-ions-on-the-binding-reaction-of-epigallocatechin-gallate-to-%C3%AE-lactoglobulin
#10
Liangliang Zhang, Indra Dev Sahu, Man Xu, Yongmei Wang, Xinyu Hu
The effects of metal ions (Cu(2+), Sn(2+), Zn(2+), Mn(2+), Al(3+) and Fe(3+)) on the interaction between (-)-epigallocatechin-3-gallate (EGCg) and β-lactoglobulin (β-Lg) were investigated via fluorescence and circular dichroism (CD) spectroscopy. The results of the fluorescence titration experiment demonstrated that the addition of Cu(2+) increases the quenching efficiency of EGCg to β-Lg by more than EGCg alone, while Mn(2+), Al(3+) and Zn(2+) decrease the quenching efficiency of EGCg to β-Lg by less than EGCg alone...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27957290/magnetic-resonance-enterography-in-300-known-cases-of-crohn-s-disease-an-initial-report-from-a-referral-center-in-iran
#11
Amir Reza Radmard, Sepehr Haghighi, Amir Pejman Hashemi Taheri, Payam Mohammadinejad, Rana Eftekhar Vaghefi, Sara Naybandi Atashi, Neda Pak, Leila Aghaghazvini, Reza Malekzadeh
BACKGROUND Magnetic resonance enterography (MRE) has become the modality of choice in assessment of patients with Crohn's disease (CD). We aimed to present our experience on 300 patients with CD who underwent MRE during the first 30 months after setting up MRE for the first time in a referral center in Iran. METHODS Patients with a definite diagnosis of CD based on either ileocolonoscopy or histopathological studies were included in the final report and categorized into four phenotypes of inactive, active, stricturing, and penetrating disease...
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27940604/rates-of-hospitalization-among-african-american-and-caucasian-american-patients-with-crohn-s-disease-seen-at-a-tertiary-care-center
#12
Caroline H Walker, Sumant S Arora, Lisandro D Colantonio, Donny D Kakati, Paul S Fitzmorris, Daniel I Chu, Talha A Malik
BACKGROUND: There is equivocal evidence regarding differences in the clinical course and outcomes of Crohn's disease (CD) among African Americans compared with Caucasian Americans. We sought to analyze whether African Americans with CD are more likely to be hospitalized for CD-related complications when compared with Caucasian Americans with CD. METHODS: We conducted a retrospective cohort study including 909 African Americans and Caucasian Americans with CD who were seen at our tertiary care Inflammatory Bowel Disease (IBD) referral center between 2000 and 2013...
December 10, 2016: Gastroenterology Report
https://www.readbyqxmd.com/read/27930412/zinc-deficiency-is-associated-with-poor-clinical-outcomes-in-patients-with-inflammatory-bowel-disease
#13
Shivi Siva, David T Rubin, George Gulotta, Kristin Wroblewski, Joel Pekow
BACKGROUND: Zinc plays a pivotal role in wound repair, tissue regeneration, and the immune response. Although zinc deficiency is common in patients with inflammatory bowel disease (IBD), the impact of low serum zinc levels on disease course is not known. METHODS: Patients enrolled in a prospectively collected IBD registry with at least 2 serum zinc measurements were included in the analysis. Using a logistic regression model, rates of IBD-related surgeries, IBD-related hospitalizations, and IBD-related complications were evaluated after a diagnosis of zinc deficiency (serum concentration <0...
January 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27930405/the-cost-of-crohn-s-disease-varied-health-care-expenditure-patterns-across-distinct-disease-trajectories
#14
Bhavana B Rao, Benjamin H Click, Ioannis E Koutroubakis, Claudia Ramos Rivers, Miguel Regueiro, Jason Swoger, Marc Schwartz, Jana Hashash, Arthur Barrie, Michael A Dunn, David G Binion
BACKGROUND: Patients with Crohn's disease (CD) encompass a heterogeneous disease spectrum, with variable health care utilization and expenditure patterns. Lémann Index (LI) is a metric that quantifies cumulative bowel damage and has shown utility in delineating distinct disease phenotypes. We aimed to characterize the financial burden from all medical care in CD cohort in relation to the variations in LI-based disease phenotypes. METHODS: CD patients with 5-year (y) follow-up from a prospective registry were included...
January 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27922024/improvements-in-the-long-term-outcome-of-crohn-s-disease-over-the-past-two-decades-and-the-relation-to-changes-in-medical-management-results-from-the-population-based-ibdsl-cohort
#15
Steven F G Jeuring, Tim R A van den Heuvel, Limmie Y L Liu, Maurice P Zeegers, Wim H Hameeteman, Mariëlle J L Romberg-Camps, Liekele E Oostenbrug, Ad A M Masclee, Daisy M A E Jonkers, Marieke J Pierik
OBJECTIVES: Medical treatment options and strategies for Crohn's disease (CD) have changed over the past decades. To assess its impact, we studied the evolution of the long-term disease outcome in the Dutch Inflammatory Bowel Disease South Limburg (IBDSL) cohort. METHODS: In total, 1,162 CD patients were included. Three eras were distinguished: 1991-1998 (n=316), 1999-2005 (n=387), and 2006-2011 (n=459), and patients were followed until 2014. Medication exposure and the rates of hospitalization, surgery, and phenotype progression were estimated using Kaplan-Meier survival analyses and compared between eras by multivariable Cox regression models...
December 6, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27918922/removal-of-heavy-metals-from-acid-mine-drainage-using-chicken-eggshells-in-column-mode
#16
Ting Zhang, Zhihong Tu, Guining Lu, Xingchun Duan, Xiaoyun Yi, Chuling Guo, Zhi Dang
Chicken eggshells (ES) as alkaline sorbent were immobilized in a fixed bed to remove typical heavy metals from acid mine drainage (AMD). The obtained breakthrough curves showed that the breakthrough time increased with increasing bed height, but decreased with increasing flow rate and increasing particle size. The Thomas model and bed depth service time model could accurately predict the bed dynamic behavior. At a bed height of 10 cm, a flow rate of 10 mL/min, and with ES particle sizes of 0.18-0.425 mm, for a multi-component heavy metal solution containing Cd(2+), Pb(2+) and Cu(2+), the ES capacities were found to be 1...
March 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/27917949/intravenous-hmscs-ameliorate-acute-pancreatitis-in-mice-via-secretion-of-tumor-necrosis-factor-%C3%AE-stimulated-gene-protein-6
#17
Zhigang He, Jie Hua, Daohai Qian, Jian Gong, Shengping Lin, Chenglei Xu, Ge Wei, Hongbo Meng, Tingsong Yang, Bo Zhou, Zhenshun Song
The administration of mesenchymal stem cells/multipotent mesenchymal stromal cells (MSCs) to enhance tissue repair is currently undergoing clinical trials. Some studies, including our previous work, have also revealed the beneficial effect of MSCs in severe acute pancreatitis (SAP); however, their mechanisms or mode of action remain controversial. In this study, we demonstrated that intravenously (i.v.)-administered human MSCs (hMSCs) remarkably promoted recovery from experimental SAP without significant engraftment of hMSCs in the damaged pancreas...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27909389/assessing-attention-and-disruptive-behavior-symptoms-in-preschool-age-children-the-utility-of-the-diagnostic-interview-schedule-for-children
#18
Benjamin Rolon-Arroyo, David H Arnold, Elizabeth A Harvey, Nastassja Marshall
Data are presented from two samples of preschool children to evaluate the reliability, concurrent validity, and predictive validity of the ADHD, ODD, and CD sections of the Diagnostic Interview Schedule for Children, Fourth Edition (DISC-IV). Information was obtained from a community sample of 128 children (Mage = 53.16 months; 63 girls) and from a sample of 72 externalizing children (Mage = 45.23 months; 31 girls) plus 25 control children (Mage = 44.51 months; 8 girls). In both studies, the DISC-IV was administered to parents along with parent and teacher behavior rating scales, and teacher rating scales were obtained again later to evaluate the predictive validity of the DISC-IV (after approximately 6 months in Study 1, and 3 years in Study 2)...
January 2016: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/27900058/effect-of-surgical-wound-fluids-after-intraoperative-electron-radiotherapy-on-the-cancer-stem-cell-phenotype-in-a-panel-of-human-breast-cancer-cell-lines
#19
Karolina Zaleska, Wiktoria Maria Suchorska, Anna Przybyła, Dawid Murawa
The wound healing process after surgery alters the area surrounding the original tumor and around the scar, and the modified microenvironment is more favorable for tumor recurrence. Intraoperative radiotherapy (IORT) is one of the more novel strategies in breast cancer (BC) treatment. Irradiation during surgery has effects on the tumor microenvironment, abrogating the proliferative cascade induced by surgical wound healing. The aim of the present study was to determine the effect of surgical wound fluids from IOERT treatment (RT-WF) compared with wound fluids from conservative-breast surgery only (WF) on the cancer stem cell phenotype in a panel of BC cell lines...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27900008/discovery-of-genes-from-feces-correlated-with-colorectal-cancer-progression
#20
Chia-Long Lee, Chi-Jung Huang, Shung-Haur Yang, Chun-Chao Chang, Chi-Cheng Huang, Chih-Cheng Chien, Ruey-Neng Yang
Colorectal cancer (CRC) is considered to develop slowly via a progressive accumulation of genetic mutations. Markers of CRC may serve to provide the basis for decision-making, and may assist in cancer prevention, detection and prognostic prediction. DNA and messenger (m)RNA molecules that are present in human feces faithfully represent CRC manifestations. In the present study, exogenous mouse cells verified the feasibility of total fecal RNA as a marker of CRC. Furthermore, five significant genes encoding solute carrier family 15, member 4 (SLC15A4), cluster of differentiation (CD)44, 3-oxoacid CoA-transferase 1 (OXCT1), placenta-specific 8 (PLAC8) and growth arrest-specific 2 (GAS2), which are differentially expressed in the feces of CRC patients, were verified in different CRC cell lines using quantitative polymerase chain reaction...
November 2016: Oncology Letters
keyword
keyword
84712
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"