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https://www.readbyqxmd.com/read/28647976/-status-of-marriage-and-hiv-transmission-between-couples-in-newly-reported-hiv-cases-before-diagnosis-was-made-among-men-who-have-sex-with-men-in-china-2014
#1
J Li, J Han, J Xu, H L Tang, Y R Mao
Objective: To analyze the status of marriage and HIV transmission between couples in newly reported HIV cases before diagnoses were made, among men who have sex with men (MSM) in China. Methods: Baseline and follow-up information related to newly reported cases in 2014 were collected from the Chinese HIV/AIDS Comprehensive Response Information Management System. Infected MSM who were older than 22 years of age were included in this study. HIV cases were divided into sero-concordant or sero-discordant group, according to the HIV status of the couple who were tested 180 days post-diagnosis...
June 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28647686/increased-risk-of-acute-arterial-events-in-young-patients-and-severely-active-ibd-a-nationwide-french-cohort-study
#2
Julien Kirchgesner, Laurent Beaugerie, Fabrice Carrat, Nynne Nyboe Andersen, Tine Jess, Michaël Schwarzinger
OBJECTIVE: Magnitude and independent drivers of the risk of acute arterial events in IBD are still unclear. We addressed this question in patients with IBD compared with the general population at a nationwide level. DESIGN: Using the French National Hospital Discharge Database from 2008 to 2013, all patients aged 15 years or older and diagnosed with IBD were identified and followed up until 31 December 2013. The rates of incident acute arterial events were calculated and the impact of time with active disease (period around hospitalisation for IBD flare or IBD-related surgery) on the risk was assessed by Cox regression adjusted for traditional cardiovascular risk factors...
June 24, 2017: Gut
https://www.readbyqxmd.com/read/28627617/sorafenib-controls-the-epithelial%C3%A2-mesenchymal-transition-of-ovarian-cancer-cells-via-egf-and-the-cd44%C3%A2-ha-signaling-pathway-in-a-cell-type%C3%A2-dependent-manner
#3
Ga Bin Park, Hyun-Suk Ko, Daejin Kim
Cluster of differentiation (CD) 44 and epidermal growth factor (EGF) are closely involved in cellular migration and have been used as stem cell markers. Although the hyaluronan (HA)‑binding CD44 is responsible for enhanced cellular motility, the mechanism underlying its actions in various cell types and clinical conditions have yet to be elucidated. In the present study, the multikinase inhibitor sorafenib was used to investigate the diverse effects of EGF stimulation on epithelial‑mesenchymal transition (EMT) in ovarian cancer cells using immunoblotting and reverse transcription‑polymerase chain reaction...
June 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28627089/analysis-of-ptpn22-zfat-and-myo9b-polymorphisms-in-turner-syndrome-and-risk-of-autoimmune-disease
#4
E Villanueva-Ortega, B Ahedo, M A Fonseca-Sánchez, J Pérez-Durán, N Garibay-Nieto, M T Macías-Galavíz, Y Trujillo-Cabrera, E García-Latorre, G Queipo
Turner syndrome (TS) is one of the most common sexual chromosome abnormalities and is clearly associated with an increased risk of autoimmune diseases, particularly thyroid disease and coeliac disease (CD). Single-nucleotide polymorphism analyses have been shown to provide correlative evidence that specific genes are associated with autoimmune disease. Our aim was to study the functional polymorphic variants of PTPN22 and ZFAT in relation to thyroid disease and those of MYO9B in relation to CD. A cross-sectional comparative analysis was performed on Mexican mestizo patients with TS and age-matched healthy females...
June 18, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28618663/chemical-characteristics-and-source-apportionment-of-pm2-5-in-lanzhou-china
#5
Jihua Tan, Leiming Zhang, Xueming Zhou, Jingchun Duan, Yan Li, Jingnan Hu, Kebin He
Daily PM2.5 samples were collected during winter 2012 and summer 2013 at an urban site in Lanzhou and were analyzed for chemical compounds including water soluble inorganic ions (WSIN), trace elements, water soluble organic carbon (WSOC), carbonaceous species (OC/EC), polycyclic aromatic hydrocarbons (PAHs), and humic-like substances (HULIS). The seasonal-average reconstructed PM2.5 mass was 120.5μgm(-3) in winter and 34.1μgm(-3) in summer. The top three groups of species in PM2.5 were OC (35.4±13.9μgm(-3)), WSIN (34...
June 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28614620/a-systematic-review-of-segmental-vs-subtotal-colectomy-and-subtotal-colectomy-vs-total-proctocolectomy-for-colonic-crohn-s-disease
#6
REVIEW
Imerio Angriman, Giovanni Pirozzolo, Romeo Bardini, Francesco Cavallin, Carlo Castoro, Marco Scarpa
AIM: Surgical management of colonic Crohn's disease (CD) is still unclear because different procedures can be adopted. The choice of operation is dependent on the involvement of colonic disease but the advantages and disadvantages of the extent of resection are still debated. METHOD: The aim of the present study is to evaluate the differences in short-term and long-term outcomes of adult patients with colonic CD, who underwent either subtotal colectomy and ileorectal anastomosis (STC) or segmental colectomy (SC) or total proctocolectomy and end ileostomy (TPC)...
June 14, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28611271/expression-of-natural-killer-cell-inhibitory-receptors-is-associated-with-significant-liver-injury-in-chronic-hepatitis-c-in-children
#7
Anna Mania, Mariusz Kaczmarek, Pawel Kemnitz, Magdalena Figlerowicz, Jan Sikora, Wojciech Sluzewski, Jan Zeromski
INTRODUCTION AND AIM: Natural Killer (NK) cells play an important role in innate immune response to viral infections and their high proportion is situated in the liver. The aim of this study was to analyze possible relation between the expression of NK cell receptors and varied intensity of liver lesions in chronic hepatitis C (CHC) in children. MATERIAL AND METHODS: Study included 105 children with CHC - 54 boys and 51 girls, age 13.62 ± 3.48 years. Blood specimens were taken at the day of the liver biopsy...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28602313/concentration-risk-assessment-and-source-identification-of-heavy-metals-in-surface-sediments-in-yinghai-a-shellfish-cultivation-zone-in-jiaozhou-bay-china
#8
Xiaomeng Liu, Lei Zhang, Lei Zhang
To identify the affection of shellfish cultivation on sediment conditions in Yinghai shellfish cultivation zone in Jiaozhou Bay, the concentration, sources, and the potential ecological risk of heavy metals was identified. Results show the range of Cu, Zn, Pb, Cd, Cr, Hg, As and Mn are 10.15-29.98, 35.95-111.22, 12.44-27.68, 0.08-0.22, 18.03-82.32, 0.04-0.13, 4.02-7.72 and 574.07-839.33mg·kg(-1). Shellfish cultivation influences heavy metal content to some extent. Principal component analysis suggests the accumulation of Zn, Mn, and Cu mainly results from agricultural and industrial actions, Pb from traffic pollution, and Hg from coal combustion...
June 8, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28591060/body-mass-index-is-a-practical-preoperative-nutritional-index-for-postoperative-infectious-complications-after-intestinal-resection-in-patients-with-crohn-s-disease
#9
Yibin Zhu, Wei Zhou, Weilin Qi, Wei Liu, Mingyu Chen, Hepan Zhu, Jianjian Xiang, Qingwen Xie, Pengpeng Chen
The patients with Crohn's disease (CD) are often accompanied with nutritional deficiencies. Compared with other intestinal benign disease, patients with CD have the higher risk of developing postoperative complications following intestinal resection. The aim of this study was to investigate the risk factors for postoperative infectious complications (PICs) after intestinal resection for CD, as well as search a practical preoperative nutritional index for PICs in patients with CD. A total of 122 patients who underwent intestinal resection for CD during 2011 to 2015 were retrospectively analyzed...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28588890/cognitive-impairment-in-crohn-s-disease-is-associated-with-systemic-inflammation-symptom-burden-and-sleep-disturbance
#10
Daniel R van Langenberg, Greg W Yelland, Stephen R Robinson, Peter R Gibson
BACKGROUND: Patients with Crohn's disease (CD) frequently complain of cognitive difficulties such as problems with concentration and clouding of thought, yet this has scarcely been objectively defined and underlying mechanisms remain unknown. OBJECTIVE: The objective of this article is to objectively measure cognitive impairments in patients with CD compared with healthy controls, and if present, to identify potentially modifiable, contributing factors associated with cognitive impairment...
June 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28585010/high-level-leaching-of-heavy-metals-from-colorful-ceramic-foodwares-a-potential-risk-to-human
#11
Taiwo Adedoyin Aderemi, Adeniyi Abiodun Adenuga, John Adekunle Oyedele Oyekunle, Aderemi Okunola Ogunfowokan
Ceramic foodwares are among the products used by people on daily basis without being cautious of exposures to heavy metals through possible leaching from the glaze ceramics. This study investigated the levels of heavy metals found in some commonly used ceramic foodwares in Nigeria with the aim of determining levels of human exposures through the use of the ceramics. To achieve this, acid digestion was carried out for the total metal concentrations and leaching tests were done using 4% acetic acid as a leaching agent...
June 5, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28583202/systematic-review-with-meta-analysis-the-efficacy-and-safety-of-stem-cell-therapy-for-crohn-s-disease
#12
REVIEW
Yun Qiu, Man-Ying Li, Ting Feng, Rui Feng, Ren Mao, Bai-Li Chen, Yao He, Zhi-Rong Zeng, Sheng-Hong Zhang, Min-Hu Chen
BACKGROUND AND AIMS: Stem cell therapy (SCT) for the treatment of Crohn's disease (CD) is still in its infancy, and whether SCT is associated with improved outcomes is unclear. We performed a meta-analysis to evaluate the efficacy and safety of patients receiving SCT. METHODS: Electronic databases were searched for studies that reported the use of stem cells for the treatment of patients with CD. Raw data from included studies were pooled for effect estimates. Subgroup analyses were performed for exploration of heterogeneity regarding all outcomes...
June 6, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28575959/multifunctional-inulin-tethered-silver-graphene-quantum-dots-nanotheranostic-module-for-pancreatic-cancer-therapy
#13
Preeti Nigam Joshi, Sachin Agawane, Meghana C Athalye, Vrushali Jadhav, Dhiman Sarkar, Rajiv Prakash
Cancer nanotechnology is an emerging area of cancer diagnosis and therapy. Although considerable progress has been made for targeted drug delivery systems to deliver anticancer agents to particular site of interest, new nanomaterials are frequently being developed and explored for better drug delivery efficiency. In the present work, we have explored a novel nanoformulation based on silver-graphene quantum dots (Ag-GQDs) nanocomposite for its successful implementation for pancreatic cancer specific drug delivery in wistar rats...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28560289/initiation-and-maintenance-of-gastric-cancer-a-focus-on-cd44-variant-isoforms-and-cancer-stem-cells
#14
REVIEW
Yana Zavros
Gastric cancer is the third most common cause of cancer-related death. Although the incidence of gastric cancer in the United States is relatively low, it remains significantly higher in some countries, including Japan and Korea. Interactions between cancer stem cells and the tumor microenvironment can have a substantial impact on tumor characteristics and contribute to heterogeneity. The mechanisms responsible for maintaining malignant cancer stem cells within the tumor microenvironment in human gastric cancer are largely unknown...
July 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28547646/risk-factors-for-vitamin-d-deficiency-and-impact-of-repletion-in-a-tertiary-care-inflammatory-bowel-disease-population
#15
Samantha Zullow, Guruprasad Jambaulikar, Ankur Rustgi, Sandra Quezada, Raymond K Cross
INTRODUCTION: Many patients with inflammatory bowel disease (IBD) are vitamin D deficient. The purpose of our study was to identify risk factors for vitamin D deficiency in IBD and to assess the impact of vitamin D repletion on disease activity and quality of life (QOL). METHODS: Patients with at least one 25-OH vitamin D level measured between 2004 and 2011 were included. Patients with a level <30 ng/ml at baseline were followed until the time of repletion...
May 25, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28538471/foreign-body-response-to-silicone-in-cochlear-implant-electrodes-in-the-human
#16
Jennifer T O'Malley, Barbara J Burgess, Donald Galler, Joseph B Nadol
HYPOTHESIS: Silicone as part of a cochlear implant electrode may be responsible for a foreign body response in the human. BACKGROUND: Clinical evidence of a foreign body response to a cochlear implant has been reported. In a previous study, particulate material found within the fibrous sheath and within macrophages surrounding a cochlear implant has been identified as being consistent with platinum. However, to date, there has been no histologic evidence of a role for silicone in this cellular immune response...
May 22, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28532097/influence-of-telopeptides-on-the-structural-and-physical-properties-of-polymeric-and-monomeric-acid-soluble-type-i-collagen
#17
Róisín Holmes, Steve Kirk, Giuseppe Tronci, Xuebin Yang, David Wood
Currently two factors hinder the use of collagen as building block of regenerative devices: the limited mechanical strength in aqueous environment, and potential antigenicity. Polymeric collagen is naturally found in the cross-linked state and is mechanically tougher than the monomeric, acid-soluble collagen ex vivo. The antigenicity of collagen, on the other hand, is mainly ascribed to inter-species variations in amino acid sequences of the non-helical terminal telopeptides. These telopeptides can be removed through enzymatic treatment to produce atelocollagen, although the effect of this cleavage on triple helix organization, amino acidic composition and thermal properties is often disregarded...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28526449/predictors-of-vaginal-delivery-in-medically-indicated-early-preterm-induction-of-labor
#18
Rachel A Sievert, Spencer G Kuper, Victoria C Jauk, Melissa Parrish, Joseph R Biggio, Lorie M Harper
BACKGROUND: When delivery is indicated prior to 34 weeks, many providers perform a cesarean delivery rather than induce labor based on perceptions of a high failure rate. Given the morbidity of cesarean delivery, an accurate estimate of the success rate and factors associated with success in preterm induction of labor is important in management decisions. OBJECTIVE: We sought to develop a prediction model for successful induction of labor in preterm patients using factors known at the time the decision is made to deliver...
May 17, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28504163/effects-of-immobilization-ph-and-reaction-time-in-the-modulation-of-%C3%AE-%C3%AE-or-%C3%AE-cyclodextrins-production-by-cyclodextrin-glycosyltransferase-batch-and-continuous-process
#19
Jéssie da Natividade Schöffer, Carla Roberta Matte, Douglas Santana Charqueiro, Eliana Weber de Menezes, Tania Maria Haas Costa, Edilson Valmir Benvenutti, Rafael C Rodrigues, Plinho Francisco Hertz
This study reports the immobilization of a β-CGTase on glutaraldehyde pre-activated silica and its use to production of cyclodextrins in batch and continuous reactions. We were able to modulate the cyclodextrin production (α-, β- and γ-CD) by immobilization and changing the reaction conditions. In batch reactions, the immobilized enzyme reached to maximum productions of 4.9mgmL(-1) of α-CD, 3.6mgmL(-1) of β-CD and 3.5mgmL(-1) of γ-CD at different conditions of temperature, pH and reaction time. In continuous reactor, varying the residence time and pH it was possible to produce at pH 4...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28501592/endoscopic-and-molecular-characterization-of-colorectal-sessile-serrated-adenoma-polyps-with-cytological-dysplasia
#20
Yoshihito Tanaka, Hiro-O Yamano, Eiichiro Yamamoto, Hiro-O Matushita, Hironori Aoki, Kenjiro Yoshikawa, Ryo Takagi, Eiji Harada, Michiko Nakaoka, Yuko Yoshida, Makoto Eizuka, Tamotsu Sugai, Hiromu Suzuki, Hiroshi Nakase
BACKGROUND AND AIMS: Sessile serrated adenoma/polyps (SSA/Ps), which are precursor lesions of colorectal cancer (CRC) with BRAF mutation and the CpG island methylator phenotype (CIMP), develop cytological dysplasia (CD) during the progression of colorectal tumorigenesis. In the present study, we aimed to clarify the endoscopic and molecular signatures of SSA/Ps, with and without CD. METHODS: A series of 208 serrated lesions, including 41 hyperplastic polyps (HPs), 90 SSA/Ps, 33 SSA/Ps with CD and 44 traditional serrated adenomas (TSAs), were observed and resected using magnifying endoscopy...
May 10, 2017: Gastrointestinal Endoscopy
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