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CD 44

C C A H Bours, M J Bakker-Huvenaars, J Tramper, N Bielczyk, F Scheepers, K S Nijhof, A N Baanders, N N J Lambregts-Rommelse, P Medendorp, J C Glennon, J K Buitelaar
Autism Spectrum Disorder (ASD), Oppositional Defiant Disorder (ODD), and Conduct Disorder (CD) are often associated with emotion recognition difficulties. This is the first eye-tracking study to examine emotional face recognition (i.e., gazing behavior) in a direct comparison of male adolescents with Autism Spectrum Disorder or Oppositional Defiant Disorder/Conduct Disorder, and typically developing (TD) individuals. We also investigate the role of psychopathic traits, callous-unemotional (CU) traits, and subtypes of aggressive behavior in emotional face recognition...
June 19, 2018: European Child & Adolescent Psychiatry
Konstantinos Gerasimidis, Konstantina Zafeiropoulou, Mary Mackinder, Umer Z Ijaz, Hazel Duncan, Elaine Buchanan, Tracey Cardigan, Christine A Edwards, Paraic McGrogan, Richard K Russell
OBJECTIVES: Detection of faecal gluten immunogenic peptides (GIP) is a biomarker of recent gluten consumption. GIP levels can be used to monitor gluten intake and compliment clinical methods to evaluate compliance to gluten free diet (GFD). In this study, recent gluten intake was measured by GIP in CD children and compared to routine clinical measures to evaluate GFD compliance. METHODS: GIP was measured in 90 samples from 63 CD children (44 previously and 19 newly diagnosed with follow-up samples at 6 and 12 months on GFD)...
June 18, 2018: Journal of Pediatric Gastroenterology and Nutrition
George Yaw Hadzi, David Kofi Essumang, Godwin A Ayoko
Heavy metal contamination of selected rivers in Ghana was studied as part of a bigger project aimed at setting background standard for heavy metals in the Ghanaian environment. Water samples were collected from major mining and eight pristine areas. The samples were acid digested with aqua-regia and analyzed with ICP-MS for As, Cd, Hg, Zn, Cu, Mn, Fe, Cr, Al, V, Co, Ni, and Pb. The average concentrations (mg/L) from the pristine sites ranged from 0.002 ± 0.00(As) to 0.929 ± 0.06 (Fe) and 0.002 ± 0...
June 16, 2018: Environmental Monitoring and Assessment
Paul Rutgeerts, Christopher Gasink, Daphne Chan, Yinghua Lang, Paul Pollack, Jean-Frederic Colombel, Douglas C Wolf, Douglas Jacobstein, Jewel Johanns, Philippe Szapary, Omoniyi J Adedokun, Brian G Feagan, William J Sandborn
BACKGROUND & AIMS: We evaluated the ability of ustekinumab, a monoclonal antibody against the p40 subunit of interleukins 12 and 23, to induce endoscopic healing in patients with moderate to severe Crohn's disease (CD). METHODS: We performed an endoscopy sub-study of 334 patients with moderate to severe CD participating in 3 randomized, controlled, phase 3 studies to determine the safety and efficacy of ustekinumab induction and maintenance therapy. All patients underwent colonoscopy at baseline and week 8 of the induction studies and at week 44 of the maintenance study; all colonoscopies were assessed by a blinded central reader...
June 14, 2018: Gastroenterology
Eliza Blicharska, Małgorzata Tatarczak-Michalewska, Anita Plazińska, Wojciech Plaziński, Anna Kowalska, Anna Madejska, Monika Szymańska-Chargot, Anna Sroka-Bartnicka, Jolanta Flieger
Spinacia oleracea L. extract was immobilized on an octadecyl-bonded silica surface to produce a new sorbent for the solid-phase extraction of trace amounts of metal ions from aqueous neutral samples. A measurement of the metal content has been performed by using graphite furnace atomic absorption spectroscopy. The affinity of the investigated bivalent metal cations for the modified sorbent are in the order: Pb(II) > Cu(II) > Ni(II) > Zn(II) ≈ Cd(II) ≈ Co(II). The quantum-chemically calculated chlorophyll-a-metal ion binding energies were consistent with the measured affinities of the corresponding metal ions to the investigated sorbent...
June 13, 2018: Journal of Separation Science
Shujie Wang, Xiaoyu Dou, Ling Chen, Yan Fang, Aqiang Wang, Huaibin Shen, Zuliang Du
Extracting light from quantum dot light emitting diodes (QLEDs) by applying optical-functional nanostructures inside and outside the devices is essential for their commercial application in illumination and displays. In this paper, we demonstrate the highly effective extraction of waveguided light from the active region of QLEDs by embedding internal grating patterns fabricated using a nanoimprint lithography technique. The grating couples out waveguide mode power into the substrate without changing the device's electrical properties, resulting in an increase in both the external quantum efficiency and luminous efficiency for a green QLED from 11...
June 13, 2018: Nanoscale
Leyla Türker Şener, Celal Güven, Aziz Şener, Suzan Adin Çinar, Seyhun Solakoğlu, Işil Albeniz
Breast cancer is the most common type of cancer in females and the second most common cause of cancer mortality after lung cancer. Cancer stem cells represent a novel approach to target cancer and reduce cancer recurrence and metastasis. Many patients with breast cancer continue to smoke after receiving their diagnosis. Nicotine is a key factor in tobacco addiction and also changes some cellular functions, such as activation of mitogenic pathways, angiogenesis and cell proliferation. In the present study, the impact of nicotine was assessed in a population of MCF-7 human breast cancer cells...
July 2018: Experimental and Therapeutic Medicine
Paweł W Petryszyn, Leszek Paradowski
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) typically clinically manifest with symptoms like chronic diarrhea, cramps, abdominal pain, and rectal bleeding. However, symptoms of abnormal anorectal function seem to be of equal importance, regardless of the presence or absence of perianal disease. OBJECTIVES: The aim of this study was to assess stool patterns and the prevalence of symptoms of disordered anorectal function, particularly urgency and fecal incontinence, and their severity in patients with inflammatory bowel diseases (IBDs)...
June 12, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Q Z Wei, S Li, Q Jia, B Luo, L M Su, Q Liu, X R Yuan, Y H Wang, Y Ruan, J P Niu
Objective: To understand the pollution characteristics and assess the pollution health risks of heavy metals in atmospheric PM(2.5) in Lanzhou. Methods: According to the regional characteristics of air pollution and industrial distribution characteristics in Lanzhou, atmospheric PM(2.5) was sampled monthly in Chengguan and Xigu Districts from January, 2015 to December, 2016. Detected the concentration of PM(2.5) and 12 kinds of elements (Sb, Al, As, Be, Cd, Cr, Hg, Pb, Mn, Ni, Se and Tl) by weighing method and inductively coupled plasma mass spectrometry...
June 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Lin Lu, Yu Yue Zhao, Hong Bo Yang, Xin Lun Tian, Zuo Jun Xu, Zhao Lin Lu
BACKGROUND: Patients with Cushing's disease (CD) with hypercortisolism have an increased risk of opportunistic infection. However, most CD patients exposed to infections are diagnostic latency, leading to a poor prognosis. METHODS: Six patients in our hospital and an additional six patients in the literature were included in this study. Clinical information of CD patients with pulmonary Cryptococcus neoformans are reviewed. RESULTS: The average baseline total cortisol and ACTH in serum at 8 am of all the patients was 44...
June 5, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Nai-Yi Zhu, Xue-Song Zhao, Fei Miao
AIM: To examine the correlation between magnetic resonance imaging (MRI) and endoscopic index of severity (CDEIS) in patients with Crohn's disease (CD). METHODS: This was a retrospective study of 104 patients with CD that were treated at the Ruijin Hospital between March 2015 and May 2016. Among them, 61 patients with active CD were evaluated before/after treatment. MRI and endoscopy were performed within 7 d. CDEIS was evaluated. MRI parameters included MaRIA scores, total relative contrast enhancement (tRCE), arterial RCE (aRCE), portal RCE (pRCE), delay phase RCE (dRCE), and apparent diffusion coefficient...
June 7, 2018: World Journal of Gastroenterology: WJG
Sarah Moretti, Simona Mrakic-Sposta, Leda Roncoroni, Alessandra Vezzoli, Cinzia Dellanoce, Erika Monguzzi, Federica Branchi, Francesca Ferretti, Vincenza Lombardo, Luisa Doneda, Alice Scricciolo, Luca Elli
INTRODUCTION: High levels of reactive oxygen species (ROS) and impaired antioxidant defense systems lead to oxidative stress (OxS) and tissue injury in different intestinal and extra intestinal conditions, including celiac disease (CD). The aim of the present study was to investigate the role and potential use of ROS and other biomarkers of OxS in the clinical management of CD. METHODS: We collected duodenal specimens and blood samples from naïve patients (N-CD), patients on a gluten free diet (GFD) including responders (CD-GFD) and non-responders (NRCD)...
June 8, 2018: Clinical and Translational Gastroenterology
Kailasam Saranya, Arumugam Sundaramanickam, Sudhanshu Shekhar, Moorthy Meena, Rengasamy Subramaniyan Sathishkumar, Thangavel Balasubramanian
This paper examines the potential detoxification efficiency of heavy metals by phosphate solubilising bacteria (PSB) that were isolated from coral, sea grass and mangrove environment. Initially, four potential bacterial isolates were selected based on their phosphate solubilisation index from 42 strains and were used for the metal tolerance test. Among the four isolates, KSCAS2 exhibited maximum tolerance to heavy metals and the phenotype indicated the production of extra polymeric substances. In a multi-heavy metal experimental setup at two concentrations (100 and 200 mg L-l ), it has been demonstrated that the bacteria have extracellularly sequestered metal ions in amorphous deposits and this has been confirmed by scanning electron microscopy...
June 2, 2018: Journal of Environmental Management
Chiara Santos, Filipe Pereira
The correct identification of species in the highly divergent group of plants is crucial for several forensic investigations. Previous works had difficulties in the establishment of a rapid and robust method for the identification of plants. For instance, DNA barcoding requires the analysis of two or three different genomic regions to attain reasonable levels of discrimination. Therefore, new methods for the molecular identification of plants are clearly needed. Here we tested the utility of variable-length sequences in the chloroplast DNA (cpDNA) as a way to identify plant species...
May 29, 2018: Forensic Science International. Genetics
Bella Ungar, Tal Engel, Doron Yablecovitch, Adi Lahat, Alon Lang, Benjamin Avidan, Ofir Har-Noy, Dan Carter, Nina Levhar, Limor Selinger, Sandra Neuman, Ola Haj Natour, Miri Yavzori, Ella Fudim, Orit Picard, Uri Kopylov, Yehuda Chowers, Timna Naftali, Efrat Broide, Eyal Shachar, Rami Eliakim, Shomron Ben-Horin
OBJECTIVES: Adalimumab is usually self-injected at home, making prospective serial-sampling studies challenging and scarce. This has led to a gap in knowledge about evolution of anti-adalimumab antibodies (AAAs) over time and its correlation with clinical and inflammatory outcomes. METHODS: A program for home visits by physicians at induction, every 3 months and at event of relapse, was established prospectively for Crohn's disease (CD) patients. At each visit, patients' clinical scores were determined and sera were obtained for C-reactive protein, drug, and AAA levels...
June 5, 2018: American Journal of Gastroenterology
Piaoting Guo, Jianchao Wang, Wencang Gao, Xia Liu, Shaofei Wu, Boshun Wan, Lei Xu, Yanhua Li
Salvianolic acid B (SalB) is a water‑soluble phenolic compound, extractable from Salvia miltiorrhiza, and has previously been demonstrated to reverse tumor multidrug resistance (MDR) in colon cancer cells. Cancer stem cells (CSCs) are closely associated with drug resistance. Therefore, establishing a nude mouse model bearing human colon CSCs is important for the study of the mechanisms underlying colon cancer drug resistance as well as the reversal of drug resistance. The present study aimed to establish a nude mouse model bearing human colon CSCs and to investigate the effects of SalB on the drug resistance exhibited by the nude mouse model as well as determine its underlying mechanism...
May 29, 2018: Molecular Medicine Reports
Zhongyang Wang, Bo Meng, Wei Zhang, Jinheng Bai, Yingxin Ma, Mingda Liu
There are potential impacts of Potentially Toxic Elements (PTEs) (e.g., Cd, Cr, Ni, Cu, As, Zn, Hg, and Pb) in soil from the perspective of the ecological environment and human health, and assessing the pollution and risk level of soil will play an important role in formulating policies for soil pollution control. Lingyuan, in the west of Liaoning Province, China, is a typical low-relief terrain of a hilly area. The object of study in this research is the topsoil of farmland in this area, of which 71 soil samples are collected...
May 28, 2018: International Journal of Environmental Research and Public Health
Wei Zhu, Yang Yang Jia, Jinming Peng, Chun-Mei Li
Pancreatic lipase (PL) is a critical enzyme associated with hyperlipidemia and obesity. Our previous study suggested that persimmon tannin (PT) was the main component accounting for the anti-hyperlipidemic effects of persimmon fruits, but the underlying mechanisms were unclear. In present study, the inhibitory effect of PT on PL was studied and the possible mechanisms were evaluated by fluorescence spectroscopy, circular dichroism (CD) spectra, isothermal titration calorimetry (ITC) and molecular docking. PT had a high affinity to PL and inhibited the activity of PL with the half maximal inhibitory concertation (IC50) value of 0...
May 28, 2018: Journal of Agricultural and Food Chemistry
Jiehong Zeng, Zhengkai Liu, Shuwen Sun, Jianhong Xie, Li Cao, Pin Lv, Shengdan Nie, Bao Zhang, Bowen Xie, Siyuan Peng, Bo Jiang
Periostin (POSTN) secreted by intrahepatic cholangiocarcinoma stem cells (ICSCs) serves important roles in promoting tumor progression. The present study aimed to investigate POSTN-recruited tumor-associated macrophages (TAMs) in intrahepatic cholangiocarcinoma (ICC). A total of 50 cases were used to investigate the distribution of ICSCs and TAMs in ICC. HCCC-9810 cells were sorted by cluster of differentiation (CD)44, the expression of POSTN of CD44+ (cancer stem cells) and CD44- cells (non-cancer stem cells), and medium were evaluated by western blot analysis...
June 2018: Oncology Letters
Dandi Hou, Runze Wang, Xiaoyu Gao, Kai Wang, Zhi Lin, Jun Ge, Ting Liu, Shuai Wei, Weikang Chen, Ruohan Xie, Xiaoe Yang, Lingli Lu, Shengke Tian
Cadmium accumulation in rice grains is highly dependent on its bioavailability that affected by various physicochemical properties and microbiological processes of soil. The rhizospheric bacterial communities of rice grown in contaminated soils by means of rice cultivars highly or weakly accumulating Cd in grains (HA and LA, respectively) were investigated. HA roots absorbed 7.26- and 2.25-fold more Cd than did LA roots at low (0.44 mg kg-1 ) and high (6.66 mg kg-1 ) soil Cd levels, respectively. Regardless of Cd levels, Cd bioavailability in the rhizosphere of HA was significantly higher than that of LA...
May 22, 2018: Environmental Pollution
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