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https://www.readbyqxmd.com/read/28216208/a-rare-case-of-pediatric-lumbar-spinal-ependymoma-mimicking-meningitis
#1
Ezeali Mike Ekuma, Kiyoshi Ito, Akihiro Chiba, Yosuke Hara, Kohei Kanaya, Tetsuyoshi Horiuchi, Samuel Ohaegbulam, Kazuhiro Hongo
Spontaneous acute subarachnoid hemorrhage (SAH) from lumbar ependymoma in children is rare. We report a case of a14-year-old boy who developed sudden radicular low back pain while playing baseball. He was initially managed conservatively in a local hospital for suspected lumbar disc herniation, but later developed meningeal symptoms and fever before being referred to our hospital. There he underwent a diagnostic lumbar puncture in the emergency room; his cerebrospinal fluid suggested an SAH. Physical examination showed meningeal signs and cauda equina features...
February 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28182108/assessment-of-the-usefulness-of-multiplex-real-time-pcr-tests-in-the-diagnostic-and-therapeutic-process-of-pneumonia-in-hospitalized-children-a-single-center-experience
#2
Ewelina Gowin, Alicja Bartkowska-Śniatkowska, Katarzyna Jończyk-Potoczna, Joanna Wysocka-Leszczyńska, Waldemar Bobkowski, Piotr Fichna, Paulina Sobkowiak, Katarzyna Mazur-Melewska, Anna Bręborowicz, Jacek Wysocki, Danuta Januszkiewicz-Lewandowska
The aim of the study was assessment of the usefulness of multiplex real-time PCR tests in the diagnostic and therapeutic process in children hospitalized due to pneumonia and burdened with comorbidities. Methods. The study group included 97 children hospitalized due to pneumonia at the Karol Jonscher Teaching Hospital in Poznań, in whom multiplex real-time PCR tests (FTD respiratory pathogens 33; fast-track diagnostics) were used. Results. Positive test results of the test were achieved in 74 patients (76...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28179405/diagnostic-accuracy-of-cerebrospinal-fluid-procalcitonin-in-bacterial-meningitis-patients-with-empiric-antibiotic-pretreatment
#3
Wen Li, Xiaolong Sun, Fang Yuan, Qiong Gao, Yue Ma, Yongli Jiang, Xiai Yang, Fang Yang, Lei Ma, Wen Jiang
Accurate diagnosis of bacterial meningitis (BM) relies on cerebrospinal fluid (CSF) Gram stain and bacterial culture, which often present high false-negative rates because of the antibiotic abuse. Thus a novel and reliable diagnostic biomarker is highly required. Procalcitonin (PCT) is well demonstrated to be specifically produced from peripheral tissues by bacterial infection, which makes it a potential candidate. Here, we performed a prospective clinical study comprising a total of 143 patients to investigate the diagnostic value of CSF PCT, serum PCT and other conventional biomarkers for BM...
February 8, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28163258/proteomics-tracing-the-footsteps-of-infectious-disease
#4
Todd M Greco, Ileana M Cristea
Every year, a major cause of human disease and death worldwide is infection with the various pathogens - viruses, bacteria, fungi, and protozoa - that are intrinsic to our ecosystem. In efforts to control the prevalence of infectious disease and develop improved therapies, the scientific community has focused on building a molecular picture of pathogen infection and spread. These studies have been aimed at defining the cellular mechanisms that allow pathogen entry into hosts cells, their replication and transmission, as well as the core mechanisms of host defense against pathogens...
February 5, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28160432/detection-of-a-novel-sapelovirus-in-central-nervous-tissue-of-pigs-with-polioencephalomyelitis-in-the-usa
#5
P H E Arruda, B L Arruda, K J Schwartz, F Vannucci, T Resende, A Rovira, P Sundberg, J Nietfeld, B M Hause
An approximately 3,000 finishing swine operation in the United States experienced an outbreak of an atypical neurologic disease in 11-weeks-old pigs with an overall morbidity of 20% and case fatality rate of 30%. The clinical onset and progression of signs in affected pigs varied but included inappetence, compromised ambulation, ataxia, incoordination, mental dullness, paresis, paralysis and decreased response to environmental stimuli. Tissues from affected pigs were submitted for diagnostic investigation. Histopathologic examination of the cerebrum, cerebellum and spinal cord revealed severe lymphoplasmacytic and necrotizing polioencephalomyelitis with multifocal areas of gliosis and neuron satellitosis, suggestive of a neurotropic viral infection...
February 3, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28159179/legionnaire-s-disease-and-its-mimics-a-clinical-perspective
#6
REVIEW
Burke A Cunha, Cheston B Cunha
Whenever the cardinal manifestations of a disorder occur in similar disorders, there is potential for a disease mimic. Legionnaire's disease has protean manifestations and has the potential to mimic or be mimicked by other community acquired pneumonias (CAPs). In CAPs caused by other than Legionella species, the more characteristic features in common with legionnaire's disease the more difficult the diagnostic conundrum. In hospitalized adults with CAP, legionnaire's disease may mimic influenza or other viral pneumonias...
March 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/28158976/the-role-of-serum-procalcitonin-in-establishing-the-diagnosis-and-prognosis-of-pleural-infection
#7
Giles Dixon, Adriana Lama-Lopez, Oliver J Bintcliffe, Anna J Morley, Clare E Hooper, Nick A Maskell
BACKGROUND: Bacterial pleural infection requires prompt identification to enable appropriate investigation and treatment. In contrast to commonly used biomarkers such as C-reactive protein (CRP) and white cell count (WCC), which can be raised due to non-infective inflammatory processes, procalcitonin (PCT) has been proposed as a specific biomarker of bacterial infection. The utility of PCT in this role is yet to be validated in a large prospective trial. This study aimed to identify whether serum PCT is superior to CRP and WCC in establishing the diagnosis of bacterial pleural infection...
February 3, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28141566/dengue-fever-triggering-kawasaki-disease
#8
Ekta Agarwal, Dheeraj Shah, Piyush Gupta
BACKGROUND: Several bacterial and viral infections are listed as triggering factors for Kawasaki disease; association with dengue fever is rare. CASE CHARACTERISTICS: A 5-year-old girl who presented with fever that was confirmed to be dengue fever, and subsequently improved, except that the fever persisted. She fulfilled diagnostic criteria for Kawasaki disease on day 7 of fever. OUTCOME: Child responded satisfactorily to intravenous immunoglobulin administration...
January 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28118219/viral-meningitis-current-issues-in-diagnosis-and-treatment
#9
Fiona McGill, Michael J Griffiths, Tom Solomon
PURPOSE OF REVIEW: The purpose of this review is to give an overview of viral meningitis and then focus in on some of the areas of uncertainty in diagnostics, treatment and outcome. RECENT FINDINGS: Bacterial meningitis has been declining in incidence over recent years. Over a similar time period molecular diagnostics have increasingly been used. Because of both of these developments viral meningitis is becoming relatively more important. However, there are still many unanswered questions...
January 23, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28103204/transthoracic-ultrasonography-for-the-immunocompromised-patient-a-pilot-project-that-introduces-transthoracic-ultrasonography-for-the-follow-up-of-hematological-patients-in-romania
#10
Ioana Frinc, Petru Ilies, Florin Zaharie, Delia Dima, Alina Tanase, Ljubomir Petrov, Alexandru Irimie, Cristian Berce, Cosmin Lisencu, Ioana Berindan-Neagoe, Ciprian Tomuleasa, Anca Bojan
In the last decade, there is significant progress in clinical hematology with the discovery of targeted molecules and thus the achievement of both hematologic and molecular responses. Nevertheless, chemotherapy remains the treatment of choice for many types of hematological malignancies. Aggressive chemotherapy leads to immunosuppression, accompanied by a high rate of infections and an increased rate of treatment-related mortality. Invasive fungal infections, as well as more common bacterial and viral infections are frequent in immunocompromised patients as they are difficult to diagnose and treat...
January 18, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28096602/surface-plasmon-resonance-based-biosensor-a-new-platform-for-rapid-diagnosis-of-livestock-diseases
#11
REVIEW
Pravas Ranjan Sahoo, Parthasarathi Swain, Sudhanshu Mohan Nayak, Sudam Bag, Smruti Ranjan Mishra
Surface plasmon resonance (SPR) based biosensors are the most advanced and developed optical label-free biosensor technique used for powerful detection with vast applications in environmental protection, biotechnology, medical diagnostics, drug screening, food safety, and security as well in livestock sector. The livestock sector which contributes the largest economy of India, harbors many bacterial, viral, and fungal diseases impacting a great loss to the production and productive potential which is a major concern in both small and large ruminants...
December 2016: Veterinary World
https://www.readbyqxmd.com/read/28067676/severe-community-acquired-pneumonia-optimal-management
#12
Davide Leoni, Jordi Rello
PURPOSE OF REVIEW: Community-acquired pneumonia (CAP) is the leading cause of mortality among infectious diseases. Several efforts have been implemented to achieve better outcomes, but an important proportion of patients continue dying. This review focuses on the newest research on prognostic factors and diagnostics, opening new perspectives in the management of CAP. RECENT FINDINGS: CAP survival improved in recent years despite an increasing incidence of severe presentations...
January 6, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28054135/-community-acquired-pneumonia
#13
S Poetter-Lang, C J Herold
CLINICAL ISSUE: The diagnosis of community-acquired pneumonia (CAP) is often not possible based only on the clinical symptoms and biochemical parameters. STANDARD RADIOLOGICAL METHODS: For every patient with the suspicion of CAP, a chest radiograph in two planes should be carried out. Additionally, a risk stratification for the decision between outpatient therapy or hospitalization is recommended. METHODICAL INNOVATIONS: Based on the evaluation of the different radiological patterns as well as their extent and distribution, a rough allocation to so-called pathogen groups as well as a differentiation between viral and bacterial infections are possible; however, because different pathogens cause different patterns an accurate correlation is not feasible by relying purely on imaging...
January 2017: Der Radiologe
https://www.readbyqxmd.com/read/28029726/a-novel-strategy-for-diagnosing-viral-versus-bacterial-infection-implications-for-oral-diseases
#14
Nataly Kravchenko-Balasha, Aframian J Doron
Infections in the maxillofacial complex, including the oral cavity, are common and in certain cases may develop into a severe condition with life threating complications in healthy populations but especially in medical compromised patients (Moazzam et al, 2015). Often, treatment is based on personal experts' experience with limited accuracy obtained from diagnostic laboratory tests. Consequently, "trial and error" attempts are usually implemented until success, in the best case, is accomplished. As a result, there is a pressing need in clinical practice for developing efficient tools for understanding the pathological nature of the infection and its rapid identification based on infection biomarkers...
December 28, 2016: Oral Diseases
https://www.readbyqxmd.com/read/28012942/a-host-protein-based-assay-to-differentiate-between-bacterial-and-viral-infections-in-preschool-children-opportunity-a-double-blind-multicentre-validation-study
#15
Chantal B van Houten, Joris A H de Groot, Adi Klein, Isaac Srugo, Irena Chistyakov, Wouter de Waal, Clemens B Meijssen, Wim Avis, Tom F W Wolfs, Yael Shachor-Meyouhas, Michal Stein, Elisabeth A M Sanders, Louis J Bont
BACKGROUND: A physician is frequently unable to distinguish bacterial from viral infections. ImmunoXpert is a novel assay combining three proteins: tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), interferon gamma induced protein-10 (IP-10), and C-reactive protein (CRP). We aimed to externally validate the diagnostic accuracy of this assay in differentiating between bacterial and viral infections and to compare this test with commonly used biomarkers. METHODS: In this prospective, double-blind, international, multicentre study, we recruited children aged 2-60 months with lower respiratory tract infection or clinical presentation of fever without source at four hospitals in the Netherlands and two hospitals in Israel...
December 21, 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27995553/role-of-neutrophil-to-lymphocyte-and-monocyte-to-lymphocyte-ratios-in-the-diagnosis-of-bacterial-infection-in-patients-with-fever
#16
Are Naess, Siri Saervold Nilssen, Reidun Mo, Geir Egil Eide, Haakon Sjursen
PURPOSE: To study the role of the neutrophil:lymphocyte ratio (NLR) and monocyte:lymphocyte ratio (MLR) in discriminating between different patient groups hospitalized for fever due to infection and those without infection. METHODS: For 299 patients admitted to hospital for fever with unknown cause, a number of characteristics including NLR and MLR were recorded. These characteristics were used in a multiple multinomial regression analysis to estimate the probability of a final diagnostic group of bacterial, viral, clinically confirmed, or no infection...
December 19, 2016: Infection
https://www.readbyqxmd.com/read/27994358/retrospective-analysis-of-multiplex-polymerase-chain-reaction-based-molecular-diagnostics-ses-in-70-patients-with-suspected-central-nervous-system-infections-a-single-center-study
#17
Rama Krishnan Tiruppur Chinnappan Ramalingam, Dipanjan Chakraborty
BACKGROUND: Central nervous system (CNS) infections present a grave health care challenge due to high morbidity and mortality. Clinical findings and conventional laboratory assessments are not sufficiently distinct for specific etiologic diagnosis. Identification of pathogens is a key to appropriate therapy. AIM: In this retrospective observational study, we evaluated the efficacy and clinical utility of syndrome evaluation system (SES) for diagnosing clinically suspected CNS infections...
October 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27993295/viruses-are-prevalent-in-non-ventilated-hospital-acquired-pneumonia
#18
Andrew F Shorr, Marya D Zilberberg, Scott T Micek, Marin H Kollef
BACKGROUND: Hospital-acquired pneumonia arising in non-ventilated patients (NVHAP) is traditionally thought to be caused by bacteria, and little is known about viral etiologies in this syndrome. We sought to describe the prevalence of viruses causing NVHAP and to determine factors independently associated with the isolation of a virus. METHODS: We identified patients with NVHAP over one year and reviewed their cultures to determine etiologies. Patients with a viral process were compared to those with either negative cultures or a bacterial infection to determine variables independently associated with the recovery of a virus...
January 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/27989423/-diagnostic-and-therapeutic-contribution-of-microbiological-analysis-in-severe-microbial-keratitis-at-reims-university-hospital-between-2012%C3%A2-and-2014
#19
J Caliot, D Guindolet, A Ducasse, L Andreoletti, C Arndt
PURPOSE: To investigate the contribution of microbial analysis in the diagnosis and management of severe microbial keratitis. MATERIAL AND METHOD: This is a monocentric retrospective study at the University Hospital of Reims from January 2012 to December 2014. Corneal scrapings with infectious keratitis were subjected to routine bacterial and fungal culture. PCR was also performed to detect various viral DNA (VZV, CMV, EBV, HSV 1 & 2, adenovirus) and Acanthamoeba sp...
December 15, 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/27981498/humoral-immunity-profiling-of-subjects-with-myalgic-encephalomyelitis-using-a-random-peptide-microarray-differentiates-cases-from-controls-with-high-specificity-and-sensitivity
#20
Sahajpreet Singh, Phillip Stafford, Karen A Schlauch, Richard R Tillett, Martin Gollery, Stephen Albert Johnston, Svetlana F Khaiboullina, Kenny L De Meirleir, Shanti Rawat, Tatjana Mijatovic, Krishnamurthy Subramanian, András Palotás, Vincent C Lombardi
Myalgic encephalomyelitis (ME) is a complex, heterogeneous illness of unknown etiology. The search for biomarkers that can delineate cases from controls is one of the most active areas of ME research; however, little progress has been made in achieving this goal. In contrast to identifying biomarkers that are directly involved in the pathological process, an immunosignature identifies antibodies raised to proteins expressed during, and potentially involved in, the pathological process. Although these proteins might be unknown, it is possible to detect antibodies that react to these proteins using random peptide arrays...
December 15, 2016: Molecular Neurobiology
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