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https://www.readbyqxmd.com/read/29793119/bioaugmentation-potential-of-a-newly-isolated-strain-sphingomonas-sp-njust37-for-the-treatment-of-wastewater-containing-highly-toxic-and-recalcitrant-tricyclazole
#1
Haobo Wu, Jinyou Shen, Xinbai Jiang, Xiaodong Liu, Xiuyun Sun, Jiansheng Li, Weiqing Han, Yang Mu, Lianjun Wang
In order to develop an effective bioaugmentation strategy for the removal of highly toxic and recalcitrant tricyclazole from wastewater, a tricyclazole degrading strain was firstly successfully isolated and identified as Sphingomonas sp. NJUST37. In batch reactors, 100 mg L-1 tricyclazole could be completely removed within 102 h, which was accompanied by significant biomass increase, TOC and COD removal, as well as toxicity reduction. Chromatography analysis and density functional theory simulation indicated that monooxygenation occurred firstly, followed by triazole ring cleavage, decyanation reaction, hydration reaction, deamination, dihydroxylation and final mineralization reaction...
May 19, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29793073/bubble-generating-polymersomes-loaded-with-both-indocyanine-green-and-doxorubicin-for-effective-chemotherapy-combined-with-photothermal-therapy
#2
Dunwan Zhu, Fan Fan, Chenlu Huang, Zhiming Zhang, Yu Qin, Li Lu, Hai Wang, Xu Jin, Hanxue Zhao, Hu Yang, Chao Zhang, Jun Yang, Zhipeng Liu, Hongfan Sun, Xigang Leng, Deling Kong, Linhua Zhang
The combination of chemotherapy and photothermaltherapy (PTT) via stimuli-responsive nanovesicles has great potential in tumor treatment. In the present study, bubble-generating polymersomes, which can generate bubbles in response to low pH or hyperthermia, were fabricated to simultaneously encapsulate chemotherapeutic drug and photosensitizing agent for the synergistic chemo-photothermal tumor therapy. Photosensitizer indocyanine green (ICG) was encapsulated into the bilayer of polymersomes formed by amphiphilic triblock copolymer PCL8000 -PEG8000 -PCL8000 through thin film re-hydration method, while chemotherapeutic doxorubicin (DOX) was loaded into the hydrophilic lumen using a transmembrane ammonium bicarbonate gradient loading procedure...
May 21, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29792681/protein-based-electronic-skin-akin-to-biological-tissues
#3
Minsik Jo, Kyungtaek Min, Biswajit Roy, Sookyoung Kim, Sangmin Lee, Ji-Yong Park, Sunghwan Kim
Human skin provides an interface that transduces external stimuli into electrical signals for communication with the brain. There has been considerable effort to produce soft, flexible, and stretchable electronic skin (E-skin) devices. However, common polymers cannot imitate human skin perfectly due to their poor biocompatibility, biofunctionality, and permeability to many chemicals and biomolecules. Herein, we report on highly flexible, stretchable, conformal, molecule-permeable, and skin-adhering E-skins that combine a metallic nanowire (NW) network and silk protein hydrogel...
May 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29791915/costaria-costata-extract-suppresses-development-of-atopic-dermatitis-in-chloro-2-4-dinitrobenzene-treated-nc-nga-mice
#4
Ok-Kyung Kim, Minhee Lee, Han Ol Kwon, Dasom Lee, Jeongjin Park, Eungpil Kim, Yanghee You, Young Tae Lim, Woojin Jun, Jeongmin Lee
We investigated the potential effects of Costaria costata (CC) on atopic dermatitis (AD) development in chloro-2,4-dinitrobenzene (DNCB)-treated NC/Nga mice. CC is a brown alga distributed across the seas of Korea, China, and Japan. A total of 40 mice were randomly assigned to 5 groups with 8 mice per group: untreated Balb/c mice, AD control (0.1% w/v DNCB-treated NC/Nga mice), positive control (i.e., DNCB-treated NC/Nga mice fed a dietary supplement of 66.6 mg/kg of body weight [b.w.] of CJLP133), DNCB-treated NC/Nga mice fed a dietary supplement of 100 mg/kg b...
May 23, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29791154/high-precision-megahertz-to-terahertz-dielectric-spectroscopy-of-protein-collective-motions-and-hydration-dynamics
#5
Ali Charkhesht, Chola Regmi, Katie R Mitchell-Koch, Shengfeng Cheng, Nguyen Q Vinh
The low-frequency collective vibrational modes in proteins as well as the protein-water interface have been suggested as dominant factors controlling the efficiency of biochemical reactions and biological energy transport. It is thus crucial to uncover the mystery of hydration structure and dynamics as well as their coupling to collective motions of proteins in aqueous solutions. Here we report dielectric properties of aqueous BSA protein solutions as a model system using an extremely sensitive dielectric spectrometer with frequencies spanning from megahertz to terahertz...
May 23, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29791152/improved-force-fields-for-peptide-nucleic-acids-with-optimized-backbone-torsion-parameters
#6
Maciej Jasiński, Michael Feig, Joanna Trylska
Peptide nucleic acids are promising nucleic acid analogs for antisense therapies as they can form stable duplex and triplex structures with DNA and RNA. Computational studies of PNA-containing duplexes and triplexes are an important component for guiding their design, yet existing force fields have not been well validated and parameterized with modern computational capabilities. We present updated CHARMM and Amber force fields for PNA that greatly improve the stability of simulated PNA-containing duplexes and triplexes in comparison with experimental structures and allow such systems to be studied on microsecond time scales...
May 23, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29790739/universal-coatings-based-on-zwitterionic-dopamine-copolymer-microgels
#7
Mohammad Vatankhah-Varnoosfaderani, Xiaobo Hu, Qiaoxi Li, Hossein Adelnia, Maria Ina, Sergei S Sheiko
Multifunctional coatings that adhere to chemically-distinct substrates are vital in many industries, including automotive, aerospace, shipbuilding, construction, petrochemical, biomedical and pharmaceutical. We design well-defined, nearly monodisperse microgels that integrate hydrophobic dopamine methacrylamide (Dopamine-MA) monomers and hydrophilic zwitterionic monomers. The dopamine functionalities operate as both intra-particle crosslinkers and interfacial binders, respectively providing mechanical strength of the coatings and their strong adhesion to different substrates...
May 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29790631/allied-health-clinicians-using-translational-research-in-action-to-develop-a-reliable-stroke-audit-tool
#8
Philip Abery, Suzanne Kuys, Mary Lynch, Nancy Low Choy
OBJECTIVE: To design and establish reliability of a local stroke audit tool by engaging allied health clinicians within a privately funded hospital. METHODS: Design: Two-stage study involving a modified Delphi process to inform stroke audit tool development and inter-tester reliability. PARTICIPANTS: Allied health clinicians. INTERVENTIONS: A modified Delphi process to select stroke guideline recommendations for inclusion in the audit tool...
May 23, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29790482/a-study-of-enterocyte-membranes-during-activation-of-apoptotic-processes-in-chronic-carrageenan-induced-gastroenterocolitis
#9
Anton Tkachenko, Dmytro Marakushyn, Iuliia Kalashnyk, Yevgen Korniyenko, Anatolii Onishchenko, Tatyana Gorbach, Oksana Nakonechna, Yevgen Posokhov, Alexander Tsygankov
Aim To investigate the lipid membranes of rat enterocytes in chronic carrageenan-induced gastroenterocolitis accompanied by the activation of apoptotic processes. Methods Steady-state fluorescence spectroscopy: a study by fluorescent probes - by ortho-hydroxy derivatives of 2,5-diaryl-1,3- oxazole. Activity of apoptosis signal-regulating kinase 1 and poly (ADP-ribose) polymerase in small intestinal homogenates, blood serum levels of matrix metalloproteinase-2 and caspase-3 and the level of DNA fragmentation in small intestinal homogenates were determined...
August 1, 2018: Medicinski Glasnik
https://www.readbyqxmd.com/read/29790208/changes-in-nano-mechanical-properties-of-human-epidermal-cornified-cells-depending-on-their-proximity-to-the-skin-surface
#10
Pascale Milani, Julien Chlasta, Rawad Abdayem, Sanja Kezic, Marek Haftek
During formation of the stratum corneum (SC) barrier, terminally differentiated keratinocytes continue their maturation process within the dead superficial epidermal layer. Morphological studies of isolated human corneocytes have revealed differences between cornified envelopes purified from the deep and superficial SC. We used atomic force microscopy to measure the mechanical properties of native human corneocytes harvested by tape-stripping from different SC depths. Various conditions of data acquisition have been tested and optimized, in order to obtain exploitable and reproducible results...
May 22, 2018: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/29789818/the-effect-of-hydration-on-the-electronic-structure-and-stability-of-the-superalkali-cation-li-3
#11
Jia-Huan Hou, Di Wu, Jia-Yuan Liu, Si-Yi Li, Dan Yu, Ying Li
The interaction of the superalkali cation Li3+ with water molecules, as well as the structures and stability of the resulting water complexes are theoretically studied at the MP2/6-311++G(d,p) level. A great number of geometrical configurations were obtained for the Li3+(H2O)n (n = 1-5) complexes and Li3+ is found to have a maximum coordination number of four. Natural population analysis shows that the charge distribution of Li3+ becomes seriously uneven upon interaction with five water molecules, so it loses ring conjugation and splits in the lowest-energy isomer of Li3+(H2O)5...
May 23, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29788460/general-principles-for-pial-synangiosis-in-pediatric-moyamoya-patients-2-dimensional-operative-video
#12
David L Penn, Kyle C Wu, Kayla R Presswood, Coleman P Riordan, R Michael Scott, Edward R Smith
Pial synangiosis is a method of indirect surgical revascularization developed at our institution for the treatment of moyamoya disease in pediatric patients. Similar surgical principles are employed in adult cases, often performed because of lack of an adequate donor vessel. Standardized protocols, including preadmission for preoperative intravenous hydration and aspirin administration, as well as intraoperative electroencephalography, are routinely employed to minimize operative risk. Perioperative heparinization is not required...
May 18, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29787749/epidermal-hmgb1-activates-dermal-fibroblasts-and-causes-hypertrophic-scar-formation-in-reduced-hydration
#13
Jingling Zhao, Jianxing Yu, Yingbin Xu, Lei Chen, Fei Zhou, Qiyi Zhai, Jun Wu, Bin Shu, Shaohai Qi
High-mobility group box 1 (HMGB1) protein is a multifunctional cytokine involved in inflammatory reactions and is known to play a key role in tissue repair and fibrosis. However, the function of HMGB1 in fibrotic skin diseases, such as hypertrophic scar formation, remains unclear. In this study, HMGB1 was detected in the nuclei of epidermal cells in normal skin and had accumulated in the cytoplasm in hypertrophic scars. By establishing a keratinocyte-fibroblast co-culture and conditional medium treatment models, we found that a reduced hydration condition increased the expression and secretion of HMGB1 in keratinocytes, subsequently activating dermal fibroblasts...
May 19, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29787258/the-mode-of-action-of-adjuvants-relevance-of-physicochemical-properties-for-effects-on-the-foliar-application-cuticular-permeability-and-greenhouse-performance-of-pinoxaden
#14
Katja Arand, Elisabeth Asmus, Christian Popp, Daniel Schneider, Markus Riederer
We comprehensively studied the complexity of mode of action of adjuvants by uncoupling the parameters contributing to the spray process during foliar application of agrochemicals. The ethoxylated sorbitan esters Tween 20 and Tween 80 improved the efficiency of Pinoxaden (PXD) in controlling grass-weed species in greenhouse experiments by aiding retention, having humectant properties, maintaining the bioavailability and increasing the cuticular penetration of PXD. The non-ethoxylated sorbitan esters Span 20 and Span 80 showed minimal effects on retention, droplet hydration or cuticular penetration, resulting in poor PXD effects in the greenhouse...
May 22, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29787235/a-novel-fast-setting-mineral-trioxide-aggregate-its-formulation-chemical-physical-properties-and-cytocompatibility
#15
Song Chen, Liyang Shi, Jun Luo, Håkan Engqvist
One of the main drawbacks that limits the application of mineral trioxide aggregate in dental field is its long setting time. Mineral trioxide aggregate (MTA) with accelerated setting properties, excellent chemical-physical and biological properties is still required. In this study, an innovative mineral trioxide aggregate which consists of calcium silicates, calcium aluminates and zirconium oxide was designed to obtain fast-setting property. The optimized formulation can achieve initial setting in 10 min and final setting in 15 min, which are much faster than commercial mineral trioxide aggregate...
May 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29786712/cocrystals-of-a-1-2-4-thiadiazole-based-potent-neuroprotector-with-gallic-acid-solubility-thermodynamic-stability-relationships-and-formation-pathways
#16
Artem O Surov, Andrei V Churakov, Alexey N Proshin, Xia-Lin Dai, Tongbu Lu, German L Perlovich
Three distinct solid forms, namely anhydrous cocrystals with 2 : 1 and 1 : 1 drug/acid ratios ([TDZ : GA] (2 : 1), [TDZ : GA] (1 : 1)), and a hydrated one having 1 : 1 : 1 drug/acid/water stoichiometry ([TDZ : GA : H2O] (1 : 1 : 1)), have been formed by cocrystallization of the biologically active 1,2,4-thiadiazole derivative (TDZ) with gallic acid (GA). The thermodynamic stability relationships between the cocrystals were rationalized in terms of Gibbs energies of the formation reactions and further verified by performing a set of competitive and exchange mechanochemical reactions...
May 22, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29786710/direct-observation-of-the-oxidation-of-dna-bases-by-phosphate-radicals-formed-under-radiation-a-model-of-the-backbone-to-base-hole-transfer
#17
Jun Ma, Jean-Louis Marignier, Pascal Pernot, Chantal Houée-Levin, Anil Kumar, Michael D Sevilla, Amitava Adhikary, Mehran Mostafavi
In irradiated DNA, by the base-to-base and backbone-to-base hole transfer processes, the hole (i.e., the unpaired spin) localizes on the most electropositive base, guanine. Phosphate radicals formed via ionization events in the DNA-backbone must play an important role in the backbone-to-base hole transfer process. However, earlier studies on irradiated hydrated DNA, on irradiated DNA-models in frozen aqueous solution and in neat dimethyl phosphate showed the formation of carbon-centered radicals and not phosphate radicals...
May 22, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29785499/on-the-current-role-of-hydratases-in-biocatalysis
#18
REVIEW
Matthias Engleder, Harald Pichler
Water addition to carbon-carbon double bonds provides access to value-added products from inexpensive organic feedstock. This interesting but relatively little-studied reaction is catalysed by hydratases in a highly regio- and enantiospecific fashion with excellent atom economy. Considering that asymmetric hydration of (non-activated) carbon-carbon double bonds is virtually impossible with current organic chemistry, enzymatic hydration reactions are highly attractive for industrial applications. Hydratases have been known for several decades but their biocatalytic potential has only been explored over the past 15 years...
May 21, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29784983/thermodynamic-and-crystallographic-model-for-anion-uptake-by-hydrated-calcium-aluminate-afm-an-example-of-molybdenum
#19
Nicolas C M Marty, Sylvain Grangeon, Erik Elkaïm, Christophe Tournassat, Clémence Fauchet, Francis Claret
Amongst all cement phases, hydrated calcium aluminate (AFm) plays a major role in the retention of anionic species. Molybdenum (Mo), whose 93 Mo isotope is considered a major steel activation product, will be released mainly under the form of MoO4 2- in a radioactive waste repository. Understanding its fate is of primary importance in a safety analysis of such disposal. This necessitates models that can both predict quantitatively the sorption of Mo by AFm and determine the nature of the sorption process (i...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784362/programmable-electrochemical-flow-system-for-high-throughput-determination-of-total-antioxidant-capacity
#20
Kornautchaya Veenuttranon, Loc Thai Nguyen
The aim of this work was to develop a programmable flow system for rapid assessment of total antioxidant capacity (TAC). Novel features of the prototype include a single pressure-driven source, versatile manipulation of fluid flows, ability to adapt to different TAC assays, and compatibility with microfluidic design. Antioxidant activity was determined by electrochemical measurement of residual 2,2-diphenyl-2-picrylhydrayl hydrate (DPPH•) free radicals in the solution. The overall performance of the device was validated by the spectrophotometric method...
August 15, 2018: Talanta
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