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Esther D A van Duin, Liesbet Goossens, Dennis Hernaus, Fabiana da Silva Alves, Nicole Schmitz, Koen Schruers, Therese van Amelsvoort
BACKGROUND: 22q11.2 deletion syndrome (22q11DS) is caused by a microdeletion on chromosome 22q11.2 and associated with an increased risk to develop psychosis. The gene coding for catechol-O-methyl-transferase (COMT) is located at the deleted region, resulting in disrupted dopaminergic neurotransmission in 22q11DS, which may contribute to the increased vulnerability for psychosis. A dysfunctional motivational reward system is considered one of the salient features in psychosis and thought to be related to abnormal dopaminergic neurotransmission...
2016: Journal of Neurodevelopmental Disorders
Julia L Newton, Andreas Finkelmeyer, George Petrides, James Frith, Tim Hodgson, Laura Maclachlan, Guy MacGowan, Andrew M Blamire
OBJECTIVES: To explore potential mechanisms that underpin the cardiac abnormalities seen in chronic fatigue syndrome (CFS) using non-invasive cardiac impedance, red cell mass and plasma volume measurements. METHODS: Cardiac MR (MR) examinations were performed using 3 T Philips Intera Achieva scanner (Best, NL) in participants with CFS (Fukuda; n=47) and matched case-by-case controls. Total volume (TV), red cell volume (RCV) and plasma volume (PV) measurements were performed (41 CFS and 10 controls) using the indicator dilution technique using simultaneous 51-chromium labelling of red blood cells and 125-iodine labelling of serum albumin...
2016: Open Heart
Pankaj Garg, Ananth Kidambi, James R J Foley, Tarique Al Musa, David P Ripley, Peter P Swoboda, Bara Erhayiem, Laura E Dobson, Adam K McDiarmid, John P Greenwood, Sven Plein
BACKGROUND: Microvascular obstruction (MVO) and intramyocardial haemorrhage (IMH) are associated with adverse prognosis, independently of infarct size after reperfused ST-elevation myocardial infarction (STEMI). Mitral annular plane systolic excursion (MAPSE) is a well-established parameter of longitudinal function on echocardiography. OBJECTIVE: We aimed to investigate how acute MAPSE, assessed by a four-chamber cine-cardiovascular MR (CMR), is associated with MVO, IMH and convalescent left ventricular (LV) remodelling...
2016: Open Heart
L Pel, P A J Donkers, K Kopinga, J J Noijen
A set-up especially designed for semi-simultaneous measurements of (1)H, (23)Na and (35)Cl in ordinary cementitious materials using nuclear magnetic resonance was built. This setup makes use of the main field of a whole body magnetic resonance imaging system (Philips Intera), which has allowed us to combine two measurement setups into one, i.e., a (23)Na/(35)Cl and a (1)H insert. This 1.5 T field was chosen as a compromise between the signal-to-noise ratio of the spin-echo signal, which increases at higher frequencies, and the line broadening due to the presence of magnetic impurities of these materials, which leads to a decrease of the resolution at higher magnetic fields...
2016: Applied Magnetic Resonance
Marjorie Ramirez, Pierre Ingrand, Jean-Pierre Richer, Guillaume Herpe, Guillaume Vesselle, Samy Boucebci, Jean-Pierre Tasu
PURPOSE: There are few previous reports on maximal pelvic lymph node sizes and no data on normal mesorectal nodes. Therefore, the aim of the study was to estimate the normal size of pelvic lymph nodes and to determine the upper limits of the normal range. MATERIALS AND METHODS: Pelvic magnetic resonance imaging (MRI) examinations were prospectively carried out using a Intera 1.5 T magnet (Philips, the Netherlands), on 36 healthy volunteers (22 females, 14 males, mean age 25 years)...
May 2016: Surgical and Radiologic Anatomy: SRA
Rui Wang, Chao Li, Jie Wang, Xiaoer Wei, Yuehua Li, Yuemin Zhu, Su Zhang
BACKGROUND: Cerebrovascular segmentation plays an important role in medical diagnosis. This study was conducted to develop a threshold segmentation algorithm for automatic extraction and volumetric quantification of cerebral vessels on brain magnetic resonance angiography (MRA) images. NEW METHODS: The MRA images of 10 individuals were acquired using a 3 Tesla MR scanner (Intera-achieva SMI-2.1, Philips Medical Systems). Otsu's method was used to divide the brain MRA images into two parts, namely, foreground and background regions...
February 15, 2015: Journal of Neuroscience Methods
Farshid Mahmodi, J B Kadir, A Puteh, S S Pourdad, A Nasehi, N Soleimani
Genetic diversity and differentiation of 50 Colletotrichum spp. isolates from legume crops studied through multigene loci, RAPD and ISSR analysis. DNA sequence comparisons by six genes (ITS, ACT, Tub2, CHS-1, GAPDH, and HIS3) verified species identity of C. truncatum, C. dematium and C. gloeosporiodes and identity C. capsici as a synonym of C. truncatum. Based on the matrix distance analysis of multigene sequences, the Colletotrichum species showed diverse degrees of intera and interspecific divergence (0.0 to 1...
March 2014: Plant Pathology Journal
M Marek, S Paus, N Allert, B Mädler, T Klockgether, H Urbach, V A Coenen
Focal lesions of brainstem, thalamus, and subcortical white matter may cause movement disorders that are clinically indistinguishable from cerebellar symptoms. It is suspected that ataxia in these cases is due to damage of efferent or afferent pathways of the cerebellum. However, the precise anatomical correlate often remains undefined. We used deterministic diffusion tensor magnetic resonance imaging (DTI) tractography to study the anatomical relationship between lesions causing ataxia and efferent cerebellar pathways...
January 2015: Journal of Neurology
Rui Wang, Chao Li, Jie Wang, Xiaoer Wei, Yuehua Li, Chun Hui, Yuemin Zhu, Su Zhang
RATIONALE AND OBJECTIVES: Quantitative analysis of white matter hyperintensities (WMHs) on fluid-attenuated inversion recovery (FLAIR) images provides information for disease tracking, therapeutic efficacy assessment, and cognitive science research. This study developed an automatic segmentation method to detect and quantify WMHs on FLAIR images. This study aims to assess the accuracy and reproducibility of the proposed method. MATERIALS AND METHODS: The FLAIR images of 82 patients (58-84 years) with different WMH burdens were acquired with the same 3T scanner (Intera-achieva SMI-2...
December 2014: Academic Radiology
Simone Maurea, Pier Paolo Mainenti, Annamaria Tambasco, Massimo Imbriaco, Carmine Mollica, Ettore Laccetti, Luigi Camera, Raffaele Liuzzi, Marco Salvatore
To compare the diagnostic value of gadolinium (Gd) and ultrasmall superparamagnetic iron oxide (SPIO) contrast media for characterization of focal liver lesions (FLL), we retrospectively evaluated the results of magnetic resonance (MR) imaging in 68 patients (40 M, 28 F, age from 22 to 81 yrs) of which 36 with diagnosis of colo-rectal cancer, 26 with hepatic cirrhosis and 6 with incidental imaging detection of FLL. MR (Gyroscan Intera 1.5 T, Philips Medical Systems) study was performed using T1 and T2 fast-field-echo (FFE) and T2 turbo-spin-echo (TSE) sequences in axial and coronal views...
June 2014: Quantitative Imaging in Medicine and Surgery
S Sreenivasa, B S Palakshamurthy, K J Pampa, N K Lokanath, P A Suchetan
In the title compound, C14H12ClNO4S, the dihedral angle between the aromatic rings is 82.07 (1)° and the dihedral angle between the planes defined by the S-N-C=O fragment and the sulfonyl benzene ring is 82.46 (3)°. In the crystal, the mol-ecules are linked into C(4) chains running along [001] by strong N-H⋯O hydrogen bonds. A C-H⋯O intera-ction reinforces the [001] chains: its graph-set symbol is C(7). The chains are cross-linked into (100) sheets by further C-H⋯O inter-actions as C(6) chains along [001]...
February 1, 2014: Acta Crystallographica. Section E, Structure Reports Online
Vahideh Koochemeshki, Hamid Reza Salmanzadeh, Hojjat Sayyadi, Morteza Amestejani, Shahyad Salehi Ardabili
BACKGROUND: This study was conducted to determine whether Diabetes Mellitus (DM) is a predictor of short term mortality ; morbidity, or early readmission to hospital after Coronary Artery Bypass Graft (CABG). METHODS: We analyzed a large cohort of 952 patients who had undergone isolated CABG. The preoperative, intera operative and postoperative risk factors as well as the complications and 30-day mortality rates were compared between the diabetics and non-diabetics...
June 2013: International Cardiovascular Research Journal
J Salamon, D Wicklein, M Didié, C Lange, U Schumacher, G Adam, K Peldschus
PURPOSE: The aim of this study was to establish co-labeling of mesenchymal stromal cells (MSC) for the detection of single MSC in-vivo by MRI and histological validation. MATERIALS AND METHODS: Mouse MSC were co-labeled with fluorescent iron oxide micro-particles and carboxyfluorescein succinimidyl ester (CFSE). The cellular iron content was determined by atomic absorption spectrometry. Cell proliferation and expression of characteristic surface markers were determined by flow cytometry...
April 2014: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Ming Wai Wan, Darragh Downey, Hilary Strachan, Rebecca Elliott, Steve R Williams, Kathryn M Abel
BACKGROUND: Accumulating evidence suggests that mothers show a different pattern of brain responses when viewing their own compared to other infants. However, there is inconsistency across functional imaging studies regarding the key areas involved, and none have examined relationships between brain and behavioural responses to infants. We examined the brain regions activated when mothers viewed videos of their own infant contrasted with an unknown infant, and whether these are associated with behavioural and self-reported measures of mother-infant relations...
2014: PloS One
Z Eslami, M H Lookzadeh, M Noorishadkam, A Hashemi, R Ghilian, A Pirdehghan
BACKGROUND: Thrombocytopenia is the most common hematological abnormality which is encountered in the neonatal intensive care unit (NICU). The incidence in neonates varies greatly, depending upon the population studies. According to the frequency of thrombocytopenia and its complications and because of lack of such research in Iran, this study was performed on neonates admitted to Shahid Sadughi NICU during years 2011-2012. MATERIALS AND METHODS: In a retrospective study, 350 neonates who were admitted to NICU were enrolled in the study...
2013: Iranian Journal of Pediatric Hematology and Oncology
F A Lupo, G Sticchi, A Paladini, S C Perfetto, A Perrone, M De Benedetto, S Vitale
Sensorineural hearing loss affects one to two children out of 1000 born apparently healthy and 9% approximately of those born with the risk of different pathologies. The origin of premature deafness is unknown in 25% of children whereas it is genetic in some cases. Prevention and early diagnosis, possibly within six to eight months, aim to avoid deafness becoming a cause of disability. The aim of the present study was to establish the optimal preoperative assessment with a diagnostic imaging protocol involving the integrated use of CT and MRI in the selection of the candidates for cochlear implantation...
April 30, 2007: Neuroradiology Journal
Elvira Verduci, Carlo Pozzato, Giuseppe Banderali, Giovanni Radaelli, Chiara Arrizza, Antonio Rovere, Enrica Riva, Marcello Giovannini
AIM: To assess a relationship between longitudinal changes in liver fat content and biochemical parameters in obese children after 1-year nutritional intervention. METHODS: Forty-six obese children, 21 males and 25 females, aged 6-14 years, underwent metabolic measurements, liver ultrasonography (US) and chemical-shift magnetic resonance imaging (MRI) examinations at baseline and after 1-year nutritional intervention. A child was defined obese if her/his body mass index (BMI) was above the age- and sex-adjusted BMI Cole's curve passing through the cut-off of 30 kg/m(2) at 18 years...
September 27, 2013: World Journal of Hepatology
O Romanos, E Solomou, P Georgiadis, D Kardamakis, D Siablis
PURPOSE: To evaluate the post-radiation lesions of the bone marrow with magnetic resonance imaging (MRI) and image analysis in patients with bone metastases undergoing radiation therapy (RT). METHODS: Thirty-five patients with bone metastases were studied from June 2008 to December 2010. All patients had osseous metastases from various primary malignancies and underwent palliative RT. MRI was performed in a Philips Gyroscan Intera 1T scanner at the beginning of RT and 12-18 days later...
July 2013: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Felisa Shokida, Lora T Likova, Magali Alvarez, Tomas Cubero, Alberto Ciancia
INTRODUCTION: The effect of the unequal visual inputs in uniocular cataracts is addressed through the hypothesis that a marked inequality of the visual inputs will have an interference effect that will degrade the binocular vision relative to that of the better eye. We tested this hypothesis of reverse interference effect by both clinical and functional Magnetic Resonance Imaging assessments in an acute unilateral cataract patient. The patient was 63 year old woman who rapidly developed a dense sub-capsular cataract following steroid radio-chemotherapy treatment for breast cancer...
2013: Binocular Vision & Strabology Quarterly, Simms-Romano's
Velasco Stéphane, Burg Samuel, Delwail Vincent, Guilhot Joelle, Perdrisot Remy, Guilhot Gaudeffroy Francois, Tasu Jean-Pierre
OBJECTIVE: To evaluate the clinical impact of diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) in staging of malignant lymphoma. METHODS: Twenty-three patients with proven malignant lymphomas were prospectively enrolled. DWIBS (b=0, 1000 s/mm(2)) examinations and PET-CT were performed respectively on an Intera 1.5 T unit and a Gyroscan PET-CT scan (Philips Medical system, Best, the Netherland). The criteria for positive node involvement were a size over 10 mm or an apparent diffusion coefficient (ADC) value under 0...
November 2013: European Journal of Radiology
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