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https://www.readbyqxmd.com/read/29247211/stim2-eb3-association-and-morphology-of-dendritic-spines-in-hippocampal-neurons
#1
Ekaterina Pchitskaya, Nina Kraskovskaya, Daria Chernyuk, Elena Popugaeva, Hua Zhang, Olga Vlasova, Ilya Bezprozvanny
Mushroom spines form strong synaptic contacts and are essential for memory storage. We have previously demonstrated that neuronal store-operated calcium entry (nSOC) in hippocampal neurons is regulated by STIM2 protein. This pathway plays a key role in stability of mushroom spines and is compromised in different mice models of Alzheimer's disease (AD). Actin was thought to be the sole cytoskeleton compartment presented in dendritic spines, however, recent studies demonstrated that dynamic microtubules with EB3 capped plus-ends transiently enter spines...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29207917/functional-effects-of-snps-in-myh9-and-risks-of-nonsyndromic-orofacial-clefts
#2
Y Wang, D Li, Y Xu, L Ma, Y Lu, Z Wang, L Wang, W Zhang, Y Pan
Nonsyndromic orofacial clefts (NSOCs) are congenital newborn malformations. Myosin heavy chain 9 ( MYH9) is a candidate gene of NSOCs. To investigate the associations between single-nucleotide polymorphisms (SNPs) of MYH9 and NSOC susceptibility, a 2-stage case-control study was designed and 4 potentially functional SNPs of MYH9 (rs12107, rs2269529, rs9619601, rs5756130) were selected and genotyped by iPLEX Sequenom MassARRAY and TaqMan assay in the first stage (599 NSOC cases and 590 controls). The significant SNPs in the first stage were replicated in the second stage (676 NSOC cases and 705 controls) by TaqMan assay...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29149498/association-between-a-single-nucleotide-polymorphism-in-the-grem1-gene-and-nonsyndromic-orofacial-cleft-in-the-chinese-population
#3
Xiaotong Wang, Hongquan Song, Xiaohui Jiao, Yanru Hao, Wei Zhang, Yuwei Gao, Yong Li, Na Mi, Jiaqun Yan
BACKGROUND: Nonsyndromic orofacial cleft (NSOC) is a common craniofacial deformity among newborns. The GREM1 gene is correlated with orofacial development. The aim of our study was to investigate the association between a single-nucleotide polymorphism in the GREM1 gene and this malformation in the Chinese population. METHODS: The SNaPshot mini sequencing technique was used to genotype the locus rs1258763 of the GREM1 gene in 331 patients with NSOC and 271 individuals in a control group...
November 17, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29091533/changing-structures-and-processes-to-support-family-caregivers-of-seriously-ill-patients
#4
Richard Schulz, Scott R Beach, Esther M Friedman, Grant R Martsolf, Juleen Rodakowski, A Everette James
BACKGROUND: Although family caregivers provide a significant portion of health and support services to adults with serious illness, they are often marginalized by existing healthcare systems and procedures. OBJECTIVE: We examine the role of caregivers in existing systems of care, identify needed changes in structures and processes, and describe how these changes might be monitored and assessed and who should be accountable for implementing them. DESIGN: Based on a broad assessment of the caregiving literature, the recent National Academy of Sciences Report on family caregiving, and descriptive data from two national surveys, we describe structural and process barriers that limit caregivers' ability to provide effective care...
November 1, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28833944/genetic-variants-of-microrna-processing-genes-and-risk-of-non-syndromic-orofacial-clefts
#5
M Xu, L Ma, S Lou, Y Du, X Yin, C Zhang, L Fan, H Wang, Z Wang, W Zhang, L Wang, Y Pan
OBJECTIVE: MicroRNA (miRNA) processing genes play important roles in the craniofacial development. The aim of this study was to explore the associations between single nucleotide polymorphisms (SNPs) of miRNA processing genes with the risk of non-syndromic orofacial clefts (NSOC). METHODS: We genotyped 12 potentially functional SNPs from seven miRNA processing genes (GEMIN3, DROSHA, DGCR8, GEMIN4, PIWIL1, XPO5, and DICER) in a case-control study of 602 NSOC cases and 605 controls...
August 20, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28489749/association-between-pax7-and-ntn1-gene-polymorphisms-and-nonsyndromic-orofacial-clefts-in-a-northern-chinese-population
#6
Qiang Guo, Dongmei Li, Xiangbiao Meng, Tingting Liu, Jinna Shi, Yanru Hao, Xiaohui Jiao, Kewen Lv, Tenglong Hu, Tao Song
BACKGROUND: Nonsyndromic orofacial clefts (NSOC) are the most common orofacial congenital defect with a complex etiology. Genome-wide association studies have identified paired box protein 7 (PAX7) and netrin-1 (NTN1) as candidate susceptibility genes for NSOC in both European and Asian populations. Here, possible associations between single-nucleotide polymorphisms (SNPs) in or near PAX7 and NTN1 were investigated in relation to risk of NSOC in a northern Chinese population. METHODS: A total of 602 individuals with NSOC and 510 controls were recruited from northern China...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28228451/african-american-stroke-survivors-more-caregiving-time-but-less-caregiving-burden
#7
COMPARATIVE STUDY
Lesli E Skolarus, Vicki A Freedman, Chunyang Feng, James F Burke
BACKGROUND: Blacks have higher stroke incidence and experience greater poststroke disability than whites. To optimize care for stroke survivors, it is important to understand the amount of care that they receive and the implications for stroke caregivers. METHODS AND RESULTS: Data from 2 nationally representative, population-based studies, the NHATS (National Health and Aging Trends Study) linked to the NSOC (National Study of Caregiving), were used to identify elderly stroke survivors and their caregivers...
February 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28210993/impact-of-caregiver-activities-and-social-supports-on-multidimensional-caregiver-burden-analyses-from-nationally-representative-surveys-of-cancer-patients-and-their-caregivers
#8
Michael T Halpern, Mallorie H Fiero, Melanie L Bell
PURPOSE: Informal caregivers of individuals with cancer may experience substantial burdens. To develop interventions to support these caregivers, it is crucial to quantify and understand the domains of burdens potentially experienced by caregivers and factors contributing to each domain. METHODS: Using data from two national surveys, the National Survey of Caregiving (NSOC) linked to the National Health and Aging Trends Survey (NHATS), we identified all participants in the NHATS diagnosed with cancer who had a caregiver participating in the NSOC...
June 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28152788/factors-affecting-multidimensional-caregiver-burden-results-from-national-surveys
#9
Mallorie Fiero, Melanie Bell
301 Background: Quality of care for individuals with cancer is affected by the burden on their caregivers. For high quality care, it is important to understand domains of caregiver burden and factors affecting this burden. METHODS: Using data from two national surveys, the National Survey of Caregiving (NSOC) linked to the National Health and Aging Trends Survey (NHATS), we identified all participants in the NHATS diagnosed with cancer who had a caregiver participating in the NSOC. Twenty-two items in the NSOC related to caregiver health, mood and outlook were included in factor analysis to develop scales capturing domains of burden...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28089520/the-association-between-family-caregivers-involvement-in-managing-older-adults-medications-and-caregivers-information-seeking-behavior
#10
Marwa Noureldin, Matthew M Murawski, Holly L Mason, Gerald C Hyner, Kimberly S Plake
OBJECTIVES: 1) To explore the association between family caregivers' involvement in managing care recipients' medications and their information-seeking behavior related to caregiving; and 2) to examine the sources used by caregivers when seeking information. METHODS: A retrospective analysis of cross-sectional data from 2 national studies, the 2011 National Health and Aging Trends Study (NHATS) and its supplement, the National Study of Caregiving (NSOC), was conducted...
March 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28068523/rs12941170-at-sox9-gene-associated-with-orofacial-clefts-in-chinese
#11
Zhong-Lin Jia, Sha He, Shu-Yuan Jiang, Bi-He Zhang, Shi-Jun Duan, Jia-Yu Shi, Ning Huang, Wen-Chao Zhu, Bing Shi
OBJECTIVE: Non-syndromic orofacial cleftings (NSOCs) are considered as complex trait, which results from genetic and/or environmental modifiers. Current findings could only explain small portion of the NSOCs. SOX9 gene plays an important role during craniofacial development in animal models and the Pierre Robin sequence (PRS). However, its role in non-syndromic clefts remains unknown. DESIGN: In this study, we selected eight SNPs in and around SOX9 gene to make maximum coverage, and genotyped them by using RFLP-PCR and ligase detection reaction (LDR) methods to test its associations among 151 NSOCs (53 NSCLP, 52 NSCLO and 46 NSCPO) from Western Han Chinese population...
December 30, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27881772/store-operated-calcium-channel-complex-in-postsynaptic-spines-a-new-therapeutic-target-for-alzheimer-s-disease-treatment
#12
Hua Zhang, Suya Sun, Lili Wu, Ekaterina Pchitskaya, Olga Zakharova, Klementina Fon Tacer, Ilya Bezprozvanny
Mushroom dendritic spine structures are essential for memory storage and the loss of mushroom spines may explain memory defects in aging and Alzheimer's disease (AD). The stability of mushroom spines depends on stromal interaction molecule 2 (STIM2)-mediated neuronal-store-operated Ca2+ influx (nSOC) pathway, which is compromised in AD mouse models, in aging neurons, and in sporadic AD patients. Here, we demonstrate that the Transient Receptor Potential Canonical 6 (TRPC6) and Orai2 channels form a STIM2-regulated nSOC Ca2+ channel complex in hippocampal mushroom spines...
November 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27641664/dysregulation-of-neuronal-calcium-homeostasis-in-alzheimer-s-disease-a-therapeutic-opportunity
#13
REVIEW
Elena Popugaeva, Ekaterina Pchitskaya, Ilya Bezprozvanny
Alzheimer's disease (AD) is the disease of lost memories. Synaptic loss is a major reason for memory defects in AD. Signaling pathways involved in memory loss in AD are under intense investigation. The role of deranged neuronal calcium (Ca(2+)) signaling in synaptic loss in AD is described in this review. Familial AD (FAD) mutations in presenilins are linked directly with synaptic Ca(2+) signaling abnormalities, most likely by affecting endoplasmic reticulum (ER) Ca(2+) leak function of presenilins. Excessive ER Ca(2+) release via type 2 ryanodine receptors (RyanR2) is observed in AD spines due to increase in expression and function of RyanR2...
February 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27537108/genetic-variants-of-20q12-contributed-to-non-syndromic-orofacial-clefts-susceptibility
#14
X Yin, L Ma, Y Li, M Xu, W Wang, H Wang, H Yuan, Y Du, S Li, J Ma, H Jiang, L Wang, W Zhang, Y Pan
OBJECTIVE: Previous genomewide association studies (GWAS) identified a region near MAFB at chr20q12 associated with non-syndromic orofacial clefts (NSOC) susceptibility. However, whether other SNPs in this area could independently contribute to non-syndromic orofacial clefts in Chinese populations remained obscure. MATERIALS AND METHODS: We selected 24 SNPs based on a haplotype-tagging SNP strategy and evaluated their associations with risk of non-syndromic orofacial clefts in a large-scale two-stage case-control study with 1278 cases and 1295 controls...
January 2017: Oral Diseases
https://www.readbyqxmd.com/read/27520990/caregiving-setting-and-baby-boomer-caregiver-stress-processes-findings-from-the-national-study-of-caregiving-nsoc
#15
Heehyul Moon, Sunshine Rote, Jeff A Beaty
The aim of this study was to provide a comprehensive understanding of how the caregiving setting relates to caregiving experience among Baby Boomer caregivers (CGs). Based on a secondary data analysis (the National Study of Caregiving, N = 782), compared with CGs providing care to an older adult living in the community, CGs to older adults in non-NH residential care settings reported better emotional well-being, self-rated health, and relationship quality and less provision of assistance older adults with daily activities...
January 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/27511275/associations-between-microrna-binding-site-snps-in-fgfs-and-fgfrs-and-the-risk-of-non-syndromic-orofacial-cleft
#16
Dandan Li, Hongchuang Zhang, Lan Ma, Yue Han, Min Xu, Zhendong Wang, Hongbing Jiang, Weibing Zhang, Lin Wang, Yongchu Pan
We hypothesized that microRNA binding site single nucleotide polymorphisms (SNPs) in fibroblast growth factors (FGFs) and their receptor genes (FGFRs) may affect microRNA and mRNA interactions and are thereby associated with susceptibility of non-syndromic orofacial cleft (NSOC). Ten SNPs among the FGF and FGFR genes were selected and their associations with NSOC susceptibility were investigated in a case-control study of 602 patients with NSOC and 605 healthy controls. FGF2/rs1048201, FGF5/rs3733336 and FGF9/rs546782 showed suggestive association with NSOC susceptibility...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26882031/a-national-profile-of-family-and-unpaid-caregivers-who-assist-older-adults-with-health-care-activities
#17
Jennifer L Wolff, Brenda C Spillman, Vicki A Freedman, Judith D Kasper
IMPORTANCE: Family and unpaid caregivers commonly help older adults who are at high risk for poorly coordinated care. OBJECTIVE: To examine how caregivers' involvement in older adults' health care activities relates to caregiving responsibilities, supportive services use, and caregiving-related effects. DESIGN, SETTING, AND PARTICIPANTS: A total of 1739 family and unpaid caregivers of 1171 community-dwelling older adults with disabilities who participated in the 2011 National Health and Aging Trends Study (NHATS) and National Study of Caregiving (NSOC)...
March 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/26859331/separation-of-hemicellulose-derived-saccharides-from-wood-hydrolysate-by-lime-and-ion-exchange-resin
#18
Xiaojun Wang, Jingshun Zhuang, Yingjuan Fu, Guoyu Tian, Zhaojiang Wang, Menghua Qin
A combined process of lime treatment and mixed bed ion exchange was proposed to separate hemicellulose-derived saccharides (HDS) from prehydrolysis liquor (PHL) of lignocellulose as value added products. The optimization of lime treatment achieved up to 44.2% removal of non-saccharide organic compounds (NSOC), mainly colloidal substances, with negligible HDS degradation at 0.5% lime level and subsequent neutralization by phosphoric acid. The residual NSOC and calcium ions in lime-treated PHL were eliminated by mixed bed ion exchange...
April 2016: Bioresource Technology
https://www.readbyqxmd.com/read/26792422/tpm1-polymorphisms-and-nonsyndromic-orofacial-clefts-susceptibility-in-a-chinese-han-population
#19
Yajing Qian, Dandan Li, Lan Ma, Hongchuang Zhang, Miao Gong, Sheng Li, Hua Yuan, Weibing Zhang, Junqing Ma, Hongbing Jiang, Yongchu Pan, Lin Wang
Located at 15q22 a susceptibility region for nonsyndromic orofacial clefts (NSOC), TPM1 encodes a group of highly conserved ubiquitous actin-binding proteins involved in the muscle contraction and cytoskeleton organization. Considering the multiple functions of TPM1 gene, we investigated the potential relationship between TPM1 polymorphisms and risk of NSOC in a Chinese Han population. Four tag single nucleotide polymorphisms (tSNPs) of TPM1 (rs11071720, rs3803499, rs12148828, and rs1972041) were selected to conduct a case-control study with 673 NSOC patients and 705 unrelated healthy controls from a Chinese Han population...
May 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/26424877/neuronal-store-operated-calcium-entry-and-mushroom-spine-loss-in-amyloid-precursor-protein-knock-in-mouse-model-of-alzheimer-s-disease
#20
Hua Zhang, Lili Wu, Ekaterina Pchitskaya, Olga Zakharova, Takashi Saito, Takaomi Saido, Ilya Bezprozvanny
Alzheimer's disease (AD) is the most common reason for elderly dementia in the world. We proposed that memory loss in AD is related to destabilization of mushroom postsynaptic spines involved in long-term memory storage. We demonstrated previously that stromal interaction molecule 2 (STIM2)-regulated neuronal store-operated calcium entry (nSOC) in postsynaptic spines play a key role in stability of mushroom spines by maintaining activity of synaptic Ca(2+)/calmodulin kinase II (CaMKII). Furthermore, we demonstrated previously that the STIM2-nSOC-CaMKII pathway is downregulated in presenilin 1 M146V knock-in (PS1-M146V KI) mouse model of AD, leading to loss of hippocampal mushroom spines in this model...
September 30, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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