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JOURNAL ARTICLE
Angela McBride, Huynh Thi Le Duyen, Nguyen Lam Vuong, Phan Vinh Tho, Luong Thi Hue Tai, Nguyen Thanh Phong, Nguyen Thanh Ngoc, Lam Minh Yen, Phung Tran Huy Nhat, Tran Thuy Vi, Martin J Llewelyn, Louise Thwaites, Nguyen Van Hao, Sophie Yacoub
Dengue shock (DS) is the most severe complication of dengue infection; endothelial hyperpermeability leads to profound plasma leakage, hypovolaemia and extravascular fluid accumulation. At present, the only treatment is supportive with intravenous fluid, but targeted endothelial stabilising therapies and host immune modulators are needed. With the aim of prioritising potential therapeutics, we conducted a prospective observational study of adults (≥16 years) with DS in Vietnam from 2019-2022, comparing the pathophysiology underlying circulatory failure with patients with septic shock (SS), and investigating the association of biomarkers with clinical severity (SOFA score, ICU admission, mortality) and pulmonary vascular leak (daily lung ultrasound for interstitial and pleural fluid)...
March 27, 2024: PLoS Neglected Tropical Diseases
#22
JOURNAL ARTICLE
Trong-Nhat Phan, Hyeryon Lee, Kyung-Hwa Baek, Joo Hwan No
The protozoan parasite Leishmania donovani is the causative agent of visceral leishmaniasis (VL), a potentially fatal disease if left untreated. Given the limitations of current therapies, there is an urgent need for new, safe, and effective drugs. To discover novel antileishmanial compounds from previously unexplored chemical spaces, we conducted a high-throughput screening (HTS) of 2562 natural compounds, assessing their activity against L. donovani promastigotes and intracellular amastigotes. Utilizing the criteria of ≥70% parasite growth inhibition and ≥70% host cell (THP-1) viability, we selected 100 inhibitors for half-maximal inhibitory concentration (IC50 ) value determination...
February 28, 2024: Pathogens
#23
JOURNAL ARTICLE
Trang Huyen Lai, Jin Seok Hwang, Quang Nhat Ngo, Dong-Kun Lee, Hyun Joon Kim, Deok Ryong Kim
Adipogenic differentiation and thermogenesis in brown adipose tissue (BAT) undergo dynamic processes, altering phenotypes and gene expressions. Proper reference genes in gene expression analysis are crucial to mitigate experimental variances and ensure PCR efficacy. Unreliable reference genes can lead to erroneous gene expression quantification, resulting in data misinterpretation. This study focused on identifying suitable reference genes for mouse brown adipocyte research, utilizing brown adipocytes from the Ucp1-luciferase ThermoMouse model...
December 2024: Adipocyte
#24
JOURNAL ARTICLE
Tran Nhat Phong Dao, Sunday Amos Onikanni, Adewale Oluwaseun Fadaka, Nicole Remaliah Samantha Sibuyi, Minh Hoang Le, Hen-Hong Chang
The presence of HLA-DRB1 alleles that encode critical points associated with environmental interactions is associated with increased risk of rheumatoid arthritis caused by anti-citrullinated protein antibodies. Therefore, interleukin-6 (IL-6), a multifunctional cytokine that controls both local and systemic acute inflammatory responses through its ability to induce a phase response, plays a serious role. Its overexpression leads to pathological challenges such as rheumatoid arthritis and menopausal osteoporosis...
March 25, 2024: Journal of Biomolecular Structure & Dynamics
#25
JOURNAL ARTICLE
Ha Thanh Nguyen, Hai Pham-The, Anh Nguyen Tuan, Ha Nguyen Thi Thu, Tuyet Anh Dang Thi, Giang Le-Nhat-Thuy, Phuong Hoang Thi, Quynh Giang Nguyen Thi, Tuyen Van Nguyen
A series of new fluorinated dihydrofurano-napthoquinone compounds were sucessfully synthesized in good yields using microwave-assisted multi-component reactions of 2-hydroxy-1,4-naphthoquinone, fluorinated aromatic aldehydes, and pyridinium bromide. The products were fully characterized using spectroscopic techniques and evaluated for their anti-inflammatory activity using lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Among 12 new compounds, compounds 8b, 8d, and 8e showed high potent NO inhibitory activity in lipopolysaccharide (LPS)-stimulated RAW264...
March 22, 2024: Bioorganic & Medicinal Chemistry Letters
#26
JOURNAL ARTICLE
Cong Thai Son Nguyen, Thanh Hoa Vo, Nguyen Kim Tuyen Pham, Bui Linh Chi Huynh, Trong Nghia Ngo, Van Son Dang, Thi Kim Chi Huynh, Trong Dat Bui, Diep Xuan Ky Nguyen, Nhat Minh Phan, Dinh Tri Mai, Kim Phi Phung Nguyen, Tan Phat Nguyen
The phytochemical composition of the Combretum trifoliatum leaves was studied for the first time. Two new triterpenoid saponins, named comtrifoside A ( 1 ) and comtrifoside B ( 2 ), together with two other saponins ( 3-4 ) were purified by variously chromatographic techniques. For the first time, compound 3 was informed from the Combretum genus, as well as all of the isolated compounds ( 1-4 ) were reported from C. trifoliatum . The chemical structures of them were clearly characterised using extensive UV-VIS, IR, HRMS-ESI, and NMR experimental data...
March 22, 2024: Natural Product Research
#27
JOURNAL ARTICLE
Tho Huu Le, Dung Ngoc Phuong Ho, Hai Xuan Nguyen, Truong Nhat Van Do, Mai Thanh Thi Nguyen, Lam K Huynh, Nhan Trung Nguyen
Plants of the Zingiberaceae family, specifically those belonging to the Curcuma species, are commonly under consideration as potential therapeutic agents for the management of gastrointestinal diseases. In this study, we carried out a phytochemical study on Curcuma aromatica Salisb. (or so-called "Nghe trang" in Vietnamese) grown in Vietnam, which yields three newly discovered 3,5-diacetoxy diarylheptanoids (1-3) and six known 3,5-dihydroxyl diarylheptanoids (4-9). The bioactivity assessment shows that all isolated compounds, except compounds 3, 7, and 8, could inhibit urease...
March 20, 2024: RSC medicinal chemistry
#28
JOURNAL ARTICLE
Huiyan Jin, Yunshu Zhou, Brian C Stagg, Joshua R Ehrlich
BACKGROUND: Vision impairment (VI) is associated with falls in older adults. However, past studies have relied on geographically constrained samples with limited generalizability or self-reports of visual difficulty. To date, there have not been nationally representative studies on the association of objective measures of visual function and falls outcomes. METHODS: We used cross-sectional data from Round 11 of National Health and Aging Trends Study (NHATS), a nationally representative panel study of age-eligible Medicare beneficiaries (N = 2951)...
March 21, 2024: Journal of the American Geriatrics Society
#29
JOURNAL ARTICLE
Mirka Buist, Shahrzad Damercheli, Jan Zbinden, Minh Tat Nhat Truong, Enzo Mastinu, Max Ortiz-Catalan
Sensorimotor impairment is a prevalent condition requiring effective rehabilitation strategies. This study introduces a novel wearable device for Mindful Sensorimotor Training (MiSMT) designed for sensory and motor rehabilitation. Our MiSMT device combines motor training using myoelectric pattern recognition along sensory training using two tactile displays. This device offers a comprehensive solution, integrating electromyography and haptic feedback, lacking in existing devices. The device features eight electromyography channels, a rechargeable battery, and wireless Bluetooth or Wi-Fi connectivity for seamless communication with a computer or mobile device...
March 21, 2024: IEEE Transactions on Neural Systems and Rehabilitation Engineering
#30
JOURNAL ARTICLE
Ramzi Ibrahim, Hoang Nhat Pham, Enkhtsogt Sainbayar, João Paulo Ferreira
The trajectory of several cardiovascular diseases (CVD), including acute myocardial infarction (AMI), has been adversely impacted by COVID-19, resulting in a worse prognosis. The Social Vulnerability Index (SVI) has been found to affect certain CVD outcomes. In this cross-sectional analysis, we investigated the association between the SVI and comorbid COVID-19 and AMI mortality using the CDC databases. The SVI percentile rankings were divided into four quartiles, and age-adjusted mortality rates were compared between the lowest and highest SVI quartiles...
February 2024: American heart journal plus: cardiology research and practice
#31
JOURNAL ARTICLE
Tran Thi Ngoc Mai, Phan Nhat Minh, Nguyen Tan Phat, Thuc Huy Duong, Tran Nguyen Minh An, Van Son Dang, Nguyen Van Hue, Mai Dinh Tri
Seven flavonoid glycosides were isolated from the aerial portions of Mussaenda recurvata during a phytochemical analysis. This comprised one novel component, ecurvoside, and six well-studied compounds, namely astragalin, isoquercitrin, nicotiflorin, rutin, hesperidin, and neohesperidin. The chemical structures of compounds were identified using spectroscopic techniques and a comparison with previously published studies. Alpha-glucosidase inhibition testing was carried out on all isolated compounds. The compounds evaluated have IC50 values between 35...
March 14, 2024: RSC Advances
#32
JOURNAL ARTICLE
Grace Gahlon, Emmanuel E Garcia Morales, Lama Assi, Nicholas S Reed
BACKGROUND AND OBJECTIVES: The objectives of this study are to identify patterns of hearing aid usage among U.S. National Health & Aging Trends Study (NHATS) participants and to examine users' characteristics associated with each pattern. RESEARCH DESIGN AND METHODS: Using data from 666 adults ages 65 and above from NHATS, we analyzed individuals' self-reported hearing aid use from eight waves of data, 2011-2018, using group-based trajectory modeling to identify clusters of individuals with similar utilization patterns of use over time...
2024: Innovation in Aging
#33
JOURNAL ARTICLE
Hai-Binh Bui, Hong-Thinh Lai, Thanh-Lam Nguyen, Thuy-Duong Vu, Nhat-Le Bui, Van-Hung Nguyen, Thi-To-Chau Tran, Thi-Phuong-Thuy Nguyen, Thi-Ngoc-Lan Nguyen, Jaffar A Al-Tawfiq, Dinh-Toi Chu
OBJECTIVES: To describe the status of using biological Disease Modifying Anti Rheumatic Drugs (bDMARDs) to treat rheumatoid arthritis (RA) and related factors. In addition, the study determined the impact of COVID-19 on the usage of bDMARDs. METHODS: This is a cross-sectional study and included 219 RA patients over 18 years old. The Kaplan-Meier method and the log-rank test (p<0.05) were used to estimate the retention time and compare between different times...
March 2024: Reumatología clinica
#34
JOURNAL ARTICLE
Seth Frndak, Zhengyi Deng, Cavin K Ward-Caviness, Irena Gorski-Steiner, Roland J Thorpe, Aisha S Dickerson
BACKGROUND: Co-exposure to air pollution and neighborhood disadvantage may influence cognition decline. We tested these associations in the context of dementia risk. METHODS: We leveraged a cohort of adults ≥65 years (n = 5397) enrolled from 2011 to 2018 in the National Health and Aging Trends Study (NHATS). Particulate matter (PM) ≤ 10 μm in diameter, PM ≤ 2.5 μm in diameter, carbon monoxide, nitric oxide, and nitrogen dioxide - and neighborhood disadvantage were tested for joint associations with dementia risk...
March 15, 2024: Environmental Research
#35
JOURNAL ARTICLE
Nguyen Nhat Quyen, Wen-Yen Tzeng, Chih-En Hsu, I-An Lin, Wan-Hsin Chen, Hao-Hsiang Jia, Sheng-Chiao Wang, Cheng-En Liu, Yu-Sheng Chen, Wei-Liang Chen, Ta-Lei Chou, I-Ta Wang, Chia-Nung Kuo, Chun-Liang Lin, Chien-Te Wu, Ping-Hui Lin, Shih-Chang Weng, Cheng-Maw Cheng, Chang-Yang Kuo, Chien-Ming Tu, Ming-Wen Chu, Yu-Ming Chang, Chin Shan Lue, Hung-Chung Hsueh, Chih-Wei Luo
Charge density waves (CDWs) involved with electronic and phononic subsystems simultaneously are a common quantum state in solid-state physics, especially in low-dimensional materials. However, CDW phase dynamics in various dimensions are yet to be studied, and their phase transition mechanism is currently moot. Here we show that using the distinct temperature evolution of orientation-dependent ultrafast electron and phonon dynamics, different dimensional CDW phases are verified in CuTe. When the temperature decreases, the shrinking of c-axis length accompanied with the appearance of interchain and interlayer interactions causes the quantum fluctuations (QF) of the CDW phase until 220 K...
March 16, 2024: Nature Communications
#36
REVIEW
Pham Hoang Vuong, Lam Hung Phu, Tran Hong Van Nguyen, Le Nhat Duy, Pham The Bao, Tan Dat Trinh
We introduce a comprehensive analysis of several approaches used in stock price forecasting, including statistical, machine learning, and deep learning models. The advantages and limitations of these models are discussed to provide an insight into stock price forecasting. Traditional statistical methods, such as the autoregressive integrated moving average and its variants, are recognized for their efficiency, but they also have some limitations in addressing non-linear problems and providing long-term forecasts...
2024: Science Progress
#37
REVIEW
Huy Phuong Tran, Nam Nhat Nguyen, Nguyen-Tuong Ho, Thuy Thi-Thanh Tran, Loc Thai Ly, Tuyet Thi-Diem Hoang, Dung Thi-Phuong Le, Chii-Ruey Tzeng, Van Toi Vo, Le-Giang Tran
Telemedicine is being applied in assisted reproduction technology (ART) to provide remote consultations, monitoring and support for patients. This study aimed to evaluate the potential advantages of telemedicine in ART treatment in the form of virtual consultations. Studies in which patients were using telemedicine during ART treatment were identified from four scientific databases (PudMed, EMBASE, Scopus, Web of Science). The success of fertility treatments was compared between telemedicine and in-office care, and patient satisfaction with ART through telemedicine was assessed...
November 29, 2023: Reproductive Biomedicine Online
#38
JOURNAL ARTICLE
Mai Ngoc Luu, Atsuko Imoto, Yoshimi Matsuo, Nguyen Tien Huy, Ahmad Qarawi, Shamael Thabit Mohammed Alhady, Le Van Truong, Ryuji Yoshino, Nguyen Tran Minh Duc, Kozue Tabei, Yixiao Lu, Manmeet Kaur Singh, Mai Phuong Truong, Shyam Prakash Dumre, Ian Christopher Naungayan Rocha, I-Chun Hung, Akane Fudo, Miho Sato, Sajog Kansakar, Akiko Tsukamoto, Aiko Komatsu, Guoxi Cai, Kazuhiko Moji, Thanawat Khongyot, Saruveish Mogan, Souksavath Soukdavone, Endah Dwi Hartuti, Kounnavong Thidatheb, Shiho Honda, Hyunjae Woo, Nitu Lama, Vy Thi Nhat Huynh, Huynh Le Anh Khoa, Kirellos Said Abbas, Fatma A Monib, Hoda Aly Mohamed Omran, Chiristine Samuel Rezq, Mostafa Shehata Qatora, Sze Jia Ng, Graca Jaqueline Vanessa Morena, Adriana Viola Miranda, Minh-Trang Ngo Huynh, Junko Ota, Kim Minjung, Jaemin An, Latdavanh Vorlasane, Kesshinee Gunasegaran, Fazureen Zulkefli, Belen de Jesús Lima Girón, Punita Gauchan Bhattachan, Renu Bhandari Dumre, Kishor Pandey, Sarina Yamashita, Aden Kay Celis Seposo, Jayson Zabala, Adrián Riva-Moscoso, Joyce Nicole Pineda Ordóñez, Suriyon Uitrakul, Fortunato S Principe-Meneses, Kadek Agus Surya Dila
INTRODUCTION: In the context of collective efforts taken in Japan to control the spread of COVID-19, the state of emergency and social distancing have caused a negative impact on the mental health of all residents, including foreign communities in Japan. This study aimed to evaluate the level of anxiety and its associated factors among non-Japanese residents residing in Japan during the COVID-19 pandemic. METHODS: A web-based survey in 13 languages was conducted among non-Japanese residents living in Japan during the COVID-19 situation...
2024: PloS One
#39
JOURNAL ARTICLE
Trieu-Nhat-Thanh Nguyen, Abbass Ballit, Pauline Lecomte-Grosbras, Jean-Baptiste Colliat, Tien-Tuan Dao
Uterine contractions in the myometrium occur at multiple scales, spanning both organ and cellular levels. This complex biological process plays an essential role in the fetus delivery during the second stage of labor. Several finite element models of active uterine contractions have already been developed to simulate the descent of the fetus through the birth canal. However, the developed models suffer severe reliability issues due to the uncertain parameters. In this context, the present study aimed to perform the uncertainty quantification (UQ) of the active uterine contraction simulation to advance our understanding of pregnancy mechanisms with more reliable indicators...
March 13, 2024: Medical & Biological Engineering & Computing
#40
JOURNAL ARTICLE
Alison R Huang, Thomas K M Cudjoe, George W Rebok, Bonnielin K Swenor, Jennifer A Deal
BACKGROUND: Little is known about the long-term impact of hearing and vision impairment on social isolation. This study quantifies the association between hearing, vision, and concurrent hearing and vision impairment (dual sensory impairment) and social isolation over 8 years among older adults. METHODS: Data were from the National Health and Aging Trends Study (NHATS), a cohort study (2011 - 2019) of U.S. Medicare beneficiaries aged 65 years and older. Social isolation was measured by a binary indicator incorporating four domains: living arrangement, core discussion network size, religious attendance, and social participation...
March 13, 2024: BMC Public Health
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