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https://www.readbyqxmd.com/read/29159368/palliative-care-eligibility-symptom-burden-and-quality-of-life-ratings-in-nursing-home-residents
#1
Caroline E Stephens, Lauren J Hunt, Nhat Bui, Elizabeth Halifax, Christine S Ritchie, Sei J Lee
No abstract text is available yet for this article.
November 20, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29154833/photo-based-pdt-ptt-dual-model-killing-and-imaging-of-cancer-cells-using-phycocyanin-polypyrrole-nanoparticles
#2
Subramaniyan Bharathiraja, Panchanathan Manivasagan, Madhappan Santha Moorthy, Nhat Quang Bui, Bian Jang, Thi Tuong Vy Phan, Won-Kyo Jung, Young-Mok Kim, Kang Dae Lee, Junghwan Oh
Photodynamic therapy (PDT) and photothermal therapy (PTT) using nanoparticles have gained significant attention for its therapeutic effect for cancer treatment. In the present study, we fabricated polypyrrole nanoparticles by employing bovine serum albumin-phycocyanin complex and the formulated particles were stable in various physiological solutions like water, phosphate buffered saline and culture media. The formulated nanoparticles did not cause any noticeable toxicity to MDA-MB-231 and HEK-293 cells. The obtained nanoparticles effectively killed MDA-MB-231 cells in a dual way upon laser illumination, one is through phycocyanin propagated reactive oxygen species (PDT) upon laser illumination and in another way it eradicated the treated cells by converting optical energy into heat energy (PTT)...
November 14, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29145577/photodynamic-therapy-leads-to-time-dependent-regression-of-pathologic-corneal-lymph-angiogenesis-and-promotes-high-risk-corneal-allograft-survival
#3
Yanhong Hou, Viet Nhat Hung Le, Thomas Clahsen, Ann-Charlott Schneider, Felix Bock, Claus Cursiefen
Purpose: Pathologic corneal (lymph) angiogenesis is a known risk factor for immune-mediated allograft rejections after corneal transplantation. However, there is no established treatment to regress pre-existing pathological corneal blood and lymphatic vessels. This study assessed the possibility to regress both vessel types by photodynamic therapy (PDT) after intravenous (i.v.) verteporfin injection, the influence of timing of PDT after verteporfin injection, and the effect on graft survival in high-risk keratoplasty...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29141657/local-estrogen-axis-in-the-human-bone-microenvironment-regulates-estrogen%C3%A2-receptor-positive%C3%A2-breast-cancer-cells
#4
Derek F Amanatullah, John S Tamaresis, Pauline Chu, Michael H Bachmann, Nhat M Hoang, Deborah Collyar, Aaron T Mayer, Robert B West, William J Maloney, Christopher H Contag, Bonnie L King
BACKGROUND: Approximately 70% of all breast cancers express the estrogen receptor, and are regulated by estrogen. While the ovaries are the primary source of estrogen in premenopausal women, most breast cancer is diagnosed following menopause, when systemic levels of this hormone decline. Estrogen production from androgen precursors is catalyzed by the aromatase enzyme. Although aromatase expression and local estrogen production in breast adipose tissue have been implicated in the development of primary breast cancer, the source of estrogen involved in the regulation of estrogen receptor-positive (ER+) metastatic breast cancer progression is less clear...
November 15, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29135605/novel-method-to-detect-corneal-lymphatic-vessels-in-vivo-by-intrastromal-injection-of-fluorescein
#5
Viet Nhat Hung Le, Yanhong Hou, Jens Horstmann, Felix Bock, Claus Cursiefen
PURPOSE: Corneal lymphatic vessels are clinically invisible because of their thin walls and clear lymph fluid. There is no easy and established method for in vivo imaging of corneal lymphatic vessels so far. In this study, we present a novel approach to visualize corneal lymphatic vessels in vivo by injecting intrastromal fluorescein sodium. METHODS: Six- to eight-week-old female BALB/c mice were used in the mouse model of suture-induced corneal neovascularization...
November 9, 2017: Cornea
https://www.readbyqxmd.com/read/29114848/racial-differences-in-patterns-of-use-of-rehabilitation-services-for-adults-aged-65-and-older
#6
Tamra Keeney, Alan M Jette, Vicki A Freedman, Howard Cabral
OBJECTIVES: To examine racial differences in the use of rehabilitation services and functional improvement during receipt of services. DESIGN: Secondary analysis of the 2016 National Health and Aging Trends Study (NHATS). SETTING: Standardized in-person home interviews. PARTICIPANTS: Community-dwelling Medicare enrollees (N = 6,309), 1,276 of whom reported receiving rehabilitation services in the previous 12 months. MEASUREMENTS: Self-reported use of rehabilitation services, setting (inpatient, outpatient, home based), reason for use, and perceptions of change in functioning after receiving services...
November 8, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29091533/changing-structures-and-processes-to-support-family-caregivers-of-seriously-ill-patients
#7
Richard Schulz, Scott R Beach, Esther M Friedman, Grant R Martsolf, Juleen Rodakowski, A Everette James
BACKGROUND: Although family caregivers provide a significant portion of health and support services to adults with serious illness, they are often marginalized by existing healthcare systems and procedures. OBJECTIVE: We examine the role of caregivers in existing systems of care, identify needed changes in structures and processes, and describe how these changes might be monitored and assessed and who should be accountable for implementing them. DESIGN: Based on a broad assessment of the caregiving literature, the recent National Academy of Sciences Report on family caregiving, and descriptive data from two national surveys, we describe structural and process barriers that limit caregivers' ability to provide effective care...
November 1, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29075651/modeling-physiologic-microenvironments-in-three-dimensional-microtumors-maintains-brain-tumor-initiating-cells
#8
Ashley N Gilbert, Kiera Walker, Anh Nhat Tran, Nathaniel H Boyd, G Yancey Gillespie, Raj K Singh, Anita B Hjelmeland
Development of effective novel anti-tumor treatments will require improved in vitro models that incorporate physiologic microenvironments and maintain intratumoral heterogeneity, including tumor initiating cells. Brain tumor initiating cells (BTIC) are a target for cancer therapy, because BTICs are highly tumorigenic and contribute to tumor angiogenesis, invasion, and therapeutic resistance. Current leading studies rely on BTIC isolation from patient-derived xenografts followed by propagation as neurospheres...
2017: Journal of Cancer Stem Cell Research
https://www.readbyqxmd.com/read/29072969/a-new-benzofuran-derivative-from-the-leaves-of-ficus-pumila-l
#9
Pham Thi Nhat Trinh, Nguyen Huu An, Pham Ngoc An, Mai Dinh Tri, Cao Van Du, Phan Nhat Minh, Nguyen Thi Le Thuy, Nguyen Trong Tuan, Vang Thi Kim Thoa, Nguyen Ngoc Tuan, Le Tien Dung
A new benzofuran derivative, pumiloside (1), together with seven known flavonoid glycosides, afzelin (2), astragalin (3), quercitrin (4), isoquercitrin (5), kaempferol 3-O-rutinoside (6), rutin (7) and kaempferol 3-O-sophoroside (8) were isolated from the leaves of Ficus pumila. Their structures were established by spectroscopic data and comparison with the literature values.
October 26, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29061970/white-matter-microstructure-is-associated-with-functional-cognitive-and-emotional-symptoms-12-months-after-mild-traumatic-brain-injury
#10
Torgeir Hellstrøm, Lars T Westlye, Tobias Kaufmann, Nhat Trung Doan, Helene L Søberg, Solrun Sigurdardottir, Wibeke Nordhøy, Eirik Helseth, Ole A Andreassen, Nada Andelic
Identifying patients at risk of poor outcome after mild traumatic brain injury (MTBI) is essential to aid prognostics and treatment. Diffuse axonal injury (DAI) may be the primary pathologic feature of MTBI but is normally not detectable by conventional imaging technology. This lack of sensitivity of clinical imaging techniques has impeded a pathophysiologic understanding of the long-term cognitive and emotional consequences of MTBI, which often remain unnoticed and are attributed to factors other than the injury...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29060458/improved-microrna-biomarkers-for-pathological-stages-in-lung-adenocarcinoma-via-clustering-of-dysregulated-microrna-target-associations
#11
Nhat Tran, Borzou Alipourfard, Vinay Abhyankar, Kytai Nguyen, Jon Weidanz, Jean Gao
Most of cancer-related deaths are due to lung cancer, and there is a need for reliable prognosis biomarkers to predict stages in lung adenocarcinoma cases. Recently, microRNAs are found to have potential as both biomarkers and therapeutic targets for lung cancer. As evidence suggests microRNA dysregulations are implicated in many cancer malignancies, it is important to consider the changes in miRNA-target associations among different lung cancer biological states. We proposed a novel clustering strategy to identify groups of miRNAs with similar dysregulated targets...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29051978/symptom-prevalence-bother-and-treatment-satisfaction-in-men-with-lower-urinary-tract-symptoms-in-southeast-asia-a-multinational-cross-sectional-survey
#12
Lap-Yin Ho, Peggy Sau-Kwan Chu, David Terrence Consigliere, Zulkifli Md Zainuddin, David Bolong, Chi-Kwok Chan, Molly Eng, Dac Nhat Huynh, Wachira Kochakarn, Marie Carmela M Lapitan, Dinh Khanh Le, Quang Dung Le, Frank Lee, Bannakij Lojanapiwat, Bao-Ngoc Nguyen, Teng-Aik Ong, Buenaventura Jose Reyes, Apirak Santingamkun, Woon-Chau Tsang, Paul Abrams
PURPOSE: The overall objective of the survey was to systematically examine patients' perspectives on lower urinary tract symptoms (LUTS) and their treatment in Southeast Asia. METHODS: A multinational cross-sectional survey involving adult men seeking consultation at urology outpatient clinics because of LUTS in Southeast Asia was conducted using convenience sampling. Self-reported prevalence, bother, treatment and treatment satisfaction of selected LUTS including urgency, nocturia, slow stream, and post-micturition dribble were evaluated...
October 19, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29046993/synthesis-and-in-vitro-performance-of-polypyrrole-coated-iron-platinum-nanoparticles-for-photothermal-therapy-and-photoacoustic-imaging
#13
Thi Tuong Vy Phan, Nhat Quang Bui, Madhappan Santha Moorthy, Kang Dae Lee, Junghwan Oh
Multifunctional nano-platform for the combination of photo-based therapy and photoacoustic imaging (PAI) for cancer treatment has recently attracted much attention to nanotechnology development. In this study, we developed iron-platinum nanoparticles (FePt NPs) with the polypyrrole (PPy) coating as novel agents for combined photothermal therapy (PTT) and PAI. The obtained PPy-coated FePt NPs (FePt@PPy NPs) showed excellent biocompatibility, photothermal stability, and high near-infrared (NIR) absorbance for the combination of PTT and PAI...
October 18, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29042809/implementation-of-gina-guidelines-in-asthma-management-by-primary-care-physicians-in-vietnam
#14
Vinh Nhu Nguyen, Quynh Nhat Nguyen, Pham Le An, Niels H Chavannes
BACKGROUND: Asthma control is suboptimal in Vietnam. Lack of knowledge of primary care physicians (PCPs) for asthma management may potentially be one of the causes. PURPOSE: The aim of this study was to assess the knowledge and practice of PCPs' asthma management based on the Global Initiative for Asthma (GINA) guidelines (2015 update). METHODS: A cross-sectional study with convenience sampling was conducted among PCPs in an urban and rural area of Vietnam using questionnaires related to asthma patients daily practice: use of spirometry and the asthma control test (ACT), prescription of asthma medications, and frequency of consultations...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/29027551/synthesis-of-free-standing-ta3n5-nanotube-membranes-and-flow-through-visible-light-photocatalytic-applications
#15
Lei Wang, Anca Mazare, Imgon Hwang, Seulgi So, Nhat Truong Nguyen, Patrik Schmuki
We report on free-standing Ta3N5 nanotubular membranes with open top and bottom, used as visible-light-active, flow-through photocatalytic micro-reactors. We grow first a robust anodic Ta2O5 layer, lift-off a membrane and convert to Ta3N5. Such membranes can easily, in a flow-through mode, degrade methylene blue under visible light (wavelength >400 nm) or solar illumination.
August 22, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29025661/low-systemic-toxicity-nanocarriers-fabricated-from-heparin-mpeg-and-pamam-dendrimers-for-controlled-drug-release
#16
Vu Minh Thanh, Thi Hiep Nguyen, Tuong Vi Tran, Uyen-Thi Phan Ngoc, Minh Nhat Ho, Thi Thinh Nguyen, Yen Nguyen Tram Chau, Van Thu Le, Ngoc Quyen Tran, Cuu Khoa Nguyen, Dai Hai Nguyen
In this report, poly(amide amine) (PAMAM) dendrimer and Heparin-grafted-monomethoxy polyethylene glycol (HEP-mPEG) were synthesized and characterized. In aqueous solution, the generation 4 PAMAM dendrimers (G4.0-PAMAM) existed as nanoparticles with particle size of 5.63nm. However, after electrostatic complexation with HEP-mPEG to form a core@shell structure G4.0-PAMAM@HEP-mPEG, the size of nanoparticles was significantly increased (73.82nm). The G4.0-PAMAM@HEP-mPEG nanoparticles showed their ability to effectively encapsulate doxorubicin (DOX) for prolonged and controlled release...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28957734/simplified-conditions-for-storing-and-cryopreservation-of-dental-pulp-stem-cells
#17
Nam Cong-Nhat Huynh, Son Hoang Le, Vu Nguyen Doan, Lan Thi Quynh Ngo, Ha Le Bao Tran
OBJECTIVES: This study aimed to simplify the collection, isolation and cryopreservation procedure of human dental pulp stem cells (DPSCs) to ease the establishment of dental stem cell banking. DESIGN: Extracted third molars were collected and stored either in growth medium or in gentamicin-saline (480μg/ml) for 6, 9 or 12h. DPSCs were isolated and subjected to cryopreservation by a controlled-rate or rapid freezing method in 5 or 10% DMSO. Flow cytometry and growth pattern of DPSCs before and after cryopreservation were conducted...
September 7, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28957024/sparse-covariance-matrix-estimation-by-dca-based-algorithms
#18
Duy Nhat Phan, Hoai An Le Thi, Tao Pham Dinh
This letter proposes a novel approach using the [Formula: see text]-norm regularization for the sparse covariance matrix estimation (SCME) problem. The objective function of SCME problem is composed of a nonconvex part and the [Formula: see text] term, which is discontinuous and difficult to tackle. Appropriate DC (difference of convex functions) approximations of [Formula: see text]-norm are used that result in approximation SCME problems that are still nonconvex. DC programming and DCA (DC algorithm), powerful tools in nonconvex programming framework, are investigated...
November 2017: Neural Computation
https://www.readbyqxmd.com/read/28947669/operationalisation-and-validation-of-the-stopping-elderly-accidents-deaths-and-injuries-steadi-fall-risk-algorithm-in-a-nationally-representative-sample
#19
Matthew C Lohman, Rebecca S Crow, Peter R DiMilia, Emily J Nicklett, Martha L Bruce, John A Batsis
BACKGROUND: Preventing falls and fall-related injuries among older adults is a public health priority. The Stopping Elderly Accidents, Deaths, and Injuries (STEADI) tool was developed to promote fall risk screening and encourage coordination between clinical and community-based fall prevention resources; however, little is known about the tool's predictive validity or adaptability to survey data. METHODS: Data from five annual rounds (2011-2015) of the National Health and Aging Trends Study (NHATS), a representative cohort of adults age 65 years and older in the USA...
September 25, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28906146/new-cerebroside-and-chondrocyte-proliferation-activity-of-caryota-mitis-l
#20
Pham Thi Nhat Trinh, Nguyen Thi To Quynh, Mai Dinh Tri, Phan Nhat Minh, Nguyen Thi Le Thuy, Luu Hong Truong, Nguyen Ngoc Tuan, Le Tien Dung
Caryota mitis L., a flowering plant, belongs to the family Arecaceae. In Vietnam, its fruits were used to treat joint pain. The present study was designed to investigate the phytochemicals and chondrocyte proliferation activity of C. mitis L. fruits on young human chondrocyte. The results showed that all of extracts (crude extract as well as n-hexane, chloroform, ethyl acetate and methanol fractions) were stimulated the growth of chondrocyte at 0.1 μg/mL; 0.01 μg/mL concentrations, of which the n-hexane and methanol fractions significantly increased the proliferation of chondrocyte by 30...
September 14, 2017: Natural Product Research
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