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https://www.readbyqxmd.com/read/29653109/can-older-adults-accurately-report-their-use-of-physical-rehabilitation-services
#1
Vicki A Freedman, Judith D Kasper, Alan Jette
OBJECTIVES: To explore accuracy of rehabilitation service use reports by older adults and variation in accuracy by demographic characteristics, time since use, duration, and setting (inpatient, outpatient, home). DESIGN: We calculate the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of survey-based measures from an observational panel study, the National Health and Aging Trends Study (NHATS), relative to measures developed from linked Medicare claims...
April 10, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29644094/insufficiency-of-dna-repair-enzyme-atm-promotes-naive-cd4-t-cell-loss-in-chronic-hepatitis-c-virus-infection
#2
Juan Zhao, Xindi Dang, Peixin Zhang, Lam Nhat Nguyen, Dechao Cao, Lin Wang, Xiaoyuan Wu, Zheng D Morrison, Ying Zhang, Zhansheng Jia, Qian Xie, Ling Wang, Shunbin Ning, Mohamed El Gazzar, Jonathan P Moorman, Zhi Q Yao
T cells have a crucial role in viral clearance and vaccine response; however, the mechanisms regulating their responses to viral infections or vaccinations remain elusive. In this study, we investigated T-cell homeostasis, apoptosis, DNA damage, and repair machineries in a large cohort of subjects with hepatitis C virus (HCV) infection. We found that naive CD4 T cells in chronically HCV-infected individuals (HCV T cells) were significantly reduced compared with age-matched healthy subjects. In addition, HCV T cells were prone to apoptosis and DNA damage, as evidenced by increased 8-oxoguanine expression and γH2AX/53BP1-formed DNA damage foci-hallmarks of DNA damage responses...
2018: Cell Discovery
https://www.readbyqxmd.com/read/29622848/the-hdac-inhibitor-saha-prevents-colonic-inflammation-by-suppressing-pro-inflammatory-cytokines-and-chemokines-in-dss-induced-colitis
#3
Mohmand Noor Ali, Narantsog Choijookhuu, Hideaki Takagi, Naparee Srisowanna, Mai Nguyen Nhat Huynh, Yuya Yamaguchi, Phyu Synn Oo, Myat Tin Htwe Kyaw, Katsuaki Sato, Ryoji Yamaguchi, Yoshitaka Hishikawa
Inflammatory bowel disease (IBD) is an inflammatory disorder of the gastrointestinal tract that is caused by multiple factors, including dysfunction of the immune system and genetic and epigenetic alterations. Aberrant epigenetic regulation, especially histone acetylation, was found in biopsies from IBD patients and mouse models of colitis, suggesting that an epigenetic treatment approach may be useful for IBD therapy. Therefore, we investigated the effects of the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), in a mouse model of dextran sulfate sodium (DSS)-induced colitis...
February 27, 2018: Acta Histochemica et Cytochemica
https://www.readbyqxmd.com/read/29614961/phylogenomics-and-barcoding-of-panax-toward-the-identification-of-ginseng-species
#4
V Manzanilla, A Kool, L Nguyen Nhat, H Nong Van, H Le Thi Thu, H J de Boer
BACKGROUND: The economic value of ginseng in the global medicinal plant trade is estimated to be in excess of US$2.1 billion. At the same time, the evolutionary placement of ginseng (Panax ginseng) and the complex evolutionary history of the genus is poorly understood despite several molecular phylogenetic studies. In this study, we use a full plastome phylogenomic framework to resolve relationships in Panax and to identify molecular markers for species discrimination. RESULTS: We used high-throughput sequencing of MBD2-Fc fractionated Panax DNA to supplement publicly available plastid genomes to create a phylogeny based on fully assembled and annotated plastid genomes from 60 accessions of 8 species...
April 3, 2018: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29594152/ionizing-radiation-induces-endothelial-inflammation-and-apoptosis-via-p90rsk-mediated-erk5-s496-phosphorylation
#5
Hang Thi Vu, Sivareddy Kotla, Kyung Ae Ko, Yuka Fujii, Yunting Tao, Jan Medina, Tamlyn Thomas, Megumi Hada, Anil K Sood, Pankaj Kumar Singh, Sarah A Milgrom, Sunil Krishnan, Keigi Fujiwara, Nhat-Tu Le, Jun-Ichi Abe
Adverse cardiovascular events are a leading nonmalignant cause of morbidity and mortality among cancer survivors who have been exposed to ionizing radiation (IR), but the exact mechanism of the cardiovascular complications induced by IR remains unclear. In this study we investigated the potential role of the p90RSK-ERK5 module in regulating IR-induced endothelial cell inflammation and apoptosis. Whole body radiation of mice with 2 Gy γ-ray significantly increased endothelial VCAM-1 expression; especially in the disturbed flow area in vivo ...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29590462/the-epidemiology-of-social-isolation-national-health-aging-trends-study
#6
Thomas K M Cudjoe, David L Roth, Sarah L Szanton, Jennifer L Wolff, Cynthia M Boyd, Roland J Thorpe
Objectives: Social isolation among older adults is an important but under-recognized risk for poor health outcomes. Methods are needed to identify subgroups of older adults at risk for social isolation. Methods: We constructed a typology of social isolation using data from the National Health and Aging Trends Study (NHATS) and estimated the prevalence and correlates of social isolation among community-dwelling older adults. The typology was formed from four domains: living arrangement, core discussion network size, religious attendance, and social participation...
March 26, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29584795/sensitivity-completeness-and-agreement-of-the-tuberculosis-electronic-system-in-ho-chi-minh-city-viet-nam
#7
L H Thai, L M Nhat, N Shah, S Lyss, M Ackers
Setting: Since 2011, tuberculosis (TB) clinics in Ho Chi Minh City (HCMC), Viet Nam, have been entering data from a paper-based TB treatment register into an electronic database known as VITIMES (Viet Nam TB Information Management Electronic System), which is currently used in parallel with the paper system. Objective: To evaluate the sensitivity, completeness and agreement of data in VITIMES with that of paper-based registers among TB patients co-infected with the human immunodeficiency virus (HIV) being treated for TB in HCMC...
December 21, 2017: Public Health Action
https://www.readbyqxmd.com/read/29575455/cephalosporin-resistant-escherichia-coli-isolated-from-farm-workers-and-pigs-in-northern-vietnam
#8
Son T T Dang, Valeria Bortolaia, Nhat T Thi, Huan L Quang, Anders Dalsgaard
OBJECTIVE: Antimicrobial-resistant bacteria may be transmitted between farm workers and livestock. This study aimed to determine and compare the prevalence and the genetic determinants of cefotaxime-resistant and ESBL-producing E. coli in faecal isolates from workers and pigs at 100 farms in northern Vietnam. METHODS: Farmers were interviewed about antimicrobial usage in livestock. Escherichia coli isolated on MacConkey agar containing 2 mg/L of cefotaxime (CTX) were tested for susceptibility to different cephalosporins by disk diffusion and screened for occurrence of ESBL-encoding genes by PCR...
March 25, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29567722/will-regulatory-issues-continue-to-be-a-major-barrier-to-access-to-bedaquiline-and-delamanid
#9
EDITORIAL
Tiziana Masini, Janika Hauser, Rutendo Kuwana, Nguyen Nhat Linh, Ernesto Jaramillo
No abstract text is available yet for this article.
March 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29559443/pericyte-derived-dickkopf2-regenerates-damaged-penile-neurovasculature-through-an-angiopoietin-1-tie2-pathway
#10
Guo Nan Yin, Hai-Rong Jin, Min-Ji Choi, Anita Limanjaya, Kalyan Ghatak, Nguyen Nhat Minh, Jiyeon Ock, Mi-Hye Kwon, Kang-Moon Song, Heon Joo Park, Ho Min Kim, Young-Guen Kwon, Ji-Kan Ryu, Jun-Kyu Suh
Penile erection requires well-coordinated interactions between vascular and nervous system. Penile neurovascular dysfunction is a major cause of erectile dysfunction (ED) in patients with diabetes, which causes poor response to oral phosphodiesterase-5 inhibitors. Dickkopf2 (DKK2), a Wnt antagonist, is known to promote angiogenesis. Here, using DKK2-Tg mice or DKK2 protein administration, we demonstrate that overexpression of DKK2 in diabetic mice enhances penile angiogenesis and neural regeneration and restores erectile function...
March 20, 2018: Diabetes
https://www.readbyqxmd.com/read/29545001/rehabilitation-utilization-for-falls-among-community-dwelling-older-adults-in-the-united-states-in-the-national-health-and-aging-trends-study
#11
Briana L Moreland, Laura L Durbin, Judith D Kasper, Thelma J Mielenz
OBJECTIVES: To determine the characteristics of community-dwelling older adults receiving fall-related rehabilitation. Injurious falls cost billions of dollars each year in the United States and these costs are expected to rise. Fall-related rehabilitation can presumably decrease this burden. More needs to be known about the characteristics of older adults utilizing fall-related rehabilitation services. DESIGN: Cross-sectional analysis of the fifth round (2015) of the National Health and Aging Trends Study (NHATS)...
March 12, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29534567/synthesis-of-hollow-doughnut-shape-mesoporous-silica-nanoparticle-a-case-of-self-assembly-composite-templates
#12
Nhat Tri Vo, Astam Kumar Patra, Dukjoon Kim
The new class of silica nanoparticles with unprecedented structural morphology is synthesized by hydrolysis of tetraethyl orthosilicate (TEOS) in the presence of cetyltrimethylammonium bromide (CTAB), L-arginine, and ammonium metatungstate (AMT) composite template, all in aqueous ethanol. The morphology of the synthesized mesoporous silica nanoparticles (MSNs) can be tuned from a spherical to a hollow dough-nut shape through a hollow sphere by controlling the concentration of AMT in the composite template. The formation mechanism of the hol-low doughnut shaped MSNs (hd-MSNs) is well explored by means of zeta potential, high resolution transmission electron microscopy (HRTEM) with elemental mapping analysis, and X-ray photoelectron spectroscopy...
March 13, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29507171/consensus-and-clustering-in-opinion-formation-on-networks
#13
Julia Bujalski, Grace Dwyer, Todd Kapitula, Quang-Nhat Le, Harjasleen Malvai, Jordan Rosenthal-Kay, Joshua Ruiter
Ideas that challenge the status quo either evaporate or dominate. The study of opinion dynamics in the socio-physics literature treats space as uniform and considers individuals in an isolated community, using ordinary differential equation (ODE) models. We extend these ODE models to include multiple communities and their interactions. These extended ODE models can be thought of as being ODEs on directed graphs. We study in detail these models to determine conditions under which there will be consensus and pluralism within the system...
April 13, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29502108/regulation-of-kir2-1-function-under-shear-stress-and-cholesterol-loading
#14
EDITORIAL
Nhat-Tu Le, Jun-Ichi Abe
No abstract text is available yet for this article.
March 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29500584/preclinical-evaluation-of-avermectins-as-novel-therapeutic-agents-for-alcohol-use-disorders
#15
REVIEW
Sheraz Khoja, Nhat Huynh, Alicia M P Warnecke, Liana Asatryan, Michael W Jakowec, Daryl L Davies
The deleterious effects of alcohol use disorders (AUDs) on human health have been documented worldwide. The enormous socioeconomic burden coupled with lack of efficacious pharmacotherapies underlies the need for improved treatment strategies. At present, there is a growing body of preclinical evidence that demonstrates the potential of avermectins [ivermectin (IVM), selamectin (SEL), abamectin (ABM), and moxidectin (MOX)] in treatment of AUDs. Avermectins are derived by fermentation of soil micro-organism, Streptomyces avermitilis, and have been extensively used for treatment of parasitic infections...
March 2, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29488278/an-augmented-aging-process-in-brain-white-matter-in-hiv
#16
Taylor Kuhn, Tobias Kaufmann, Nhat Trung Doan, Lars T Westlye, Jacob Jones, Rodolfo A Nunez, Susan Y Bookheimer, Elyse J Singer, Charles H Hinkin, April D Thames
OBJECTIVE: HIV infection and aging are both associated with neurodegeneration. However, whether the aging process alone or other factors associated with advanced age account for the progression of neurodegeneration in the aging HIV-positive (HIV+) population remains unclear. METHODS: HIV+ (n = 70) and HIV-negative (HIV-, n = 34) participants underwent diffusion tensor imaging (DTI) and metrics of microstructural properties were extracted from regions of interest (ROIs)...
February 27, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29478237/risky-driving-behaviors-for-older-adults-differences-by-veteran-s-status
#17
Andrea L Huseth-Zosel, Kimberly D Hammer
Veterans are at an increased risk of being injured or killed in motor vehicle crashes, potentially due to their proclivity to engage in risky driving behaviors. However, most research in this area has focused on driving behaviors of veterans who have recently returned home after deployment. No research has focused on risky driving behaviors of older veterans (aged 65 or older) and if risky driving behaviors extend beyond the time period immediately following return from deployment. The purpose of this research is to determine if differences exist in risky driving behaviors of veterans and non-veterans aged 65 or older...
February 24, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29477921/reduced-expression-of-purinergic-p2x4-receptors-increases-voluntary-ethanol-intake-in-c57bl-6j-mice
#18
Sheraz Khoja, Nhat Huynh, Liana Asatryan, Michael W Jakowec, Daryl L Davies
Purinergic P2X4 receptors (P2X4Rs) belong to the P2X superfamily of ionotropic receptors that are gated by adenosine 5'-triphosphate (ATP). Accumulating evidence indicates that P2X4Rs play an important role in regulation of ethanol intake. At the molecular level, ethanol's inhibitory effects on P2X4Rs are antagonized by ivermectin (IVM), in part, via action on P2X4Rs. Behaviorally, male mice deficient in the p2rx4 gene (P2X4R knockout [KO]) have been shown to exhibit a transient increase in ethanol intake over a period of 4 days, as demonstrated by social and binge drinking paradigms...
September 30, 2017: Alcohol
https://www.readbyqxmd.com/read/29472123/can-algae-based-technologies-be-an-affordable-green-process-for-biofuel-production-and-wastewater-remediation
#19
REVIEW
P Vo Hoang Nhat, H H Ngo, W S Guo, S W Chang, D D Nguyen, P D Nguyen, X T Bui, X B Zhang, J B Guo
Algae is a well-known organism that its characteristic is prominent for biofuel production and wastewater remediation. This critical review aims to present the applicability of algae with in-depth discussion regarding three key aspects: (i) characterization of algae for its applications; (ii) the technical approaches and their strengths and drawbacks; and (iii) future perspectives of algae-based technologies. The process optimization and combinations with other chemical and biological processes have generated efficiency, in which bio-oil yield is up to 41...
February 8, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29471789/melanin-embedded-materials-effectively-remove-hexavalent-chromium-cr-vi-from-aqueous-solution
#20
An Manh Cuong, Nguyen Thi Le Na, Pham Nhat Thang, Trinh Ngoc Diep, Ly Bich Thuy, Nguyen Lai Thanh, Nguyen Dinh Thang
BACKGROUND: Currently, it is recognized that water polluted with toxic heavy metal ions may cause serious effects on human health. Therefore, the development of new materials for effective removal of heavy metal ions from water is still a widely important area. Melanin is being considered as a potential material for removal of heavy metal from water. METHODS: In this study, we synthesized two melanin-embedded beads from two different melanin powder sources and named IMB (Isolated Melanin Bead originated from squid ink sac) and CMB (Commercial Melanin Bead originated from sesame seeds)...
February 23, 2018: Environmental Health and Preventive Medicine
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