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Suong Thi Thao Nguyen, Eiko Yamamoto, Mai Thi Ngoc Nguyen, Huy Bao Le, Tetsuyoshi Kariya, Yu Mon Saw, Cong Duc Nguyen, Nobuyuki Hamajima
Vietnam is facing a problem of over-crowding in public hospitals. Long waiting time is a major dissatisfaction for patients. Reducing waiting time benefits not only patients but also hospitals in decreasing overall workload. To identify factors contributing to long waiting time in outpatient clinics, a cross-sectional study was conducted at a national hospital in Vietnam. The time for each process of 7,931 patients who visited the outpatient clinics within Thong Nhat Hospital from 5 to 9 September 2016 was collected from the computerized clinical database...
May 2018: Nagoya Journal of Medical Science
Catherine J Libby, Sixue Zhang, Gloria A Benavides, Sarah E Scott, Yanjie Li, Matthew Redmann, Anh Nhat Tran, Arphaxad Otamias, Victor Darley-Usmar, Marek Napierala, Jianhua Zhang, Corinne Elizabeth Augelli-Szafran, Wei Zhang, Anita B Hjelmeland
Tumor heterogeneity has hampered the development of novel effective therapeutic options for aggressive cancers, including the deadly primary adult brain tumor glioblastoma (GBM). Intratumoral heterogeneity is partially attributed to the tumor initiating cell (TIC) subset that contains highly tumorigenic, stem-like cells. TICs display metabolic plasticity but can have a reliance on aerobic glycolysis. Elevated expression of GLUT1 and GLUT3 is present in many cancer types, with GLUT3 being preferentially expressed in brain TICs (BTICs) to increase survival in low nutrient tumor microenvironments, leading to tumor maintenance...
June 15, 2018: ACS Chemical Biology
Ginevra Sacripanti, Nhat Minh Nguyen, Leonardo Lorenzini, Sabina Frascarelli, Alessandro Saba, Riccardo Zucchi, Sandra Ghelardoni
3,5-diiodo-l-thyronine (T2) is an endogenous derivative of thyroid hormone that has been suggested to regulate energy expenditure, resting metabolic rate and oxygen consumption with a mechanism that involves the activation of mitochondrial function. In this study, we focused on the cardiac effects of T2, which have been poorly investigated so far, by using both in vitro and ex vivo models. As a comparison, the response to T3 and T4 was also determined. Rat cardiomyoblasts (H9c2 cells) were used to determine T2, T3, and T4 uptake by high-performance liquid chromatography-tandem mass spectrometry...
2018: Frontiers in Endocrinology
Thi Tuong Vy Phan, Nhat Quang Bui, Soon-Woo Cho, Subramaniyan Bharathiraja, Panchanathan Manivasagan, Madhappan Santha Moorthy, Sudip Mondal, Chang-Seok Kim, Junghwan Oh
Cancer theragnosis agents with both cancer diagnosis and therapy abilities would be the next generation of cancer treatment. Recently, nanomaterials with strong absorption in near-infrared (NIR) region have been explored as promising cancer theragnosis agents for bio-imaging and photothermal therapy (PTT). Herein, we reported the synthesis and application of a novel multifunctional theranostic nanoagent based on hyaluronan (HA)-coated FeOOH@polypyrrole (FeOOH@PPy) nanorods (HA-FeOOH@PPy NRs) for photoacoustic imaging (PAI)-guided PTT...
June 11, 2018: Scientific Reports
Lan Anh Thi Hoang, Ha Cam Nguyen, Thom Thi Le, Thi Huong Quynh Hoang, Van Nhat Pham, Minh Hien Thi Hoang, Hoai Thu Thi Ngo, Dang Diem Hong
Schizochytrium mangrovei strain PQ6 was investigated for co-production of docosahexaenoic acid (C22: 6ω-3, DHA) and squalene using a 30 L bioreactor with a working volume of 15 L under various batch and fed-batch fermentation process regimes. The fed-batch process was a more efficient cultivation strategy for achieving higher biomass production rich in DHA and squalene. The final biomass, total lipid, unsaponifiable lipid content and DHA productivity were 105.25 g · L-1 , 43.40% of dry cell weight, 8.58% total lipid and 61...
June 11, 2018: Journal of Phycology
Yannick Stephan, Angelina R Sutin, Antonio Terracciano
OBJECTIVE: Subjective age has been implicated in a range of health outcomes. The present study extends existing research by providing new data on the relation between subjective age and mortality in three large national samples. METHODS: Participants (total N > 17,000) were drawn from the Health and Retirement Study (HRS, 2008-2014), the Midlife in the United State Survey (MIDUS, 1995-2014), and the National Health and Aging Trends Study (NHATS, 2011-2014). Subjective age, demographic factors, disease burden, functional limitations, depressive symptoms, and physical inactivity were assessed at baseline and mortality data were tracked for up to 20 years...
June 1, 2018: Psychosomatic Medicine
Kunal Malik, Helen He, Thy Nhat Huynh, Gary Tran, Kelly Mueller, Kristina Doytcheva, Yael Renert-Yuval, Tali Czarnowicki, Shai Magidi, Margaret Chu, Yeriel D Estrada, Huei-Chi Wen, Xiangyu Peng, Hui Xu, Xiuzhong Zheng, James G Krueger, Amy S Paller, Emma Guttman-Yassky
BACKGROUND: Ichthyoses are a group of rare skin disorders lacking effective treatments. Although genetic mutations are progressively delineated, comprehensive molecular phenotyping of ichthyotic skin could suggest much-needed pathogenesis-based therapy. OBJECTIVE: To profile the molecular fingerprint of the most common orphan ichthyoses. METHODS: Gene, protein, and serum studies were performed on skin and blood samples from 29 patients (congenital ichthyosiform erythroderma/CIE, n=9; lamellar ichthyosis/LI, n=8; epidermolytic ichthyosis/EI, n=8; and Netherton syndrome/NS, n=4), as well as age-matched healthy controls (n=14), psoriasis (n=30), and atopic dermatitis/AD (n=16) patients...
May 24, 2018: Journal of Allergy and Clinical Immunology
Nhat-Thien Nguyen, Dan-Dan Zheng, Shiao-Shing Chen, Chang-Tang Chang
Hydrogen is considered as a promising energy source with its high energy yield, renewable, environment friendly properties. TiO2 modified with noble metal and nonmetal is widely used. In this study, Pt and graphene (GN) were used to modify TiO2 nanoparticles. GN/TiO2 (TG), Pt-TiO2 (PT), Pt-GN/TiO2 (PTG) was successfully synthesized by modified Hummers' method, alcohol thermal and photodeposition method, respectively. The characterizations of the synthesized catalysts by UV-vis/DRS, components analysis, XRD and TEM analysis were conducted...
January 1, 2018: Journal of Nanoscience and Nanotechnology
Tanvee Singh, Emmanuelle Bélanger, Kali Thomas
OBJECTIVES: Emerging research suggests Black older adults experience a 30% decreased risk for falls compared with their White U.S. counterparts, and this is mediated neither by physical performance nor activity. Fear of falling (FOF) is a significant risk factor for falls, yet we know little about how FOF varies by race/ethnicity. The purpose of this original research brief was to investigate the relationship between race/ethnicity and FOF among older adults. METHODS: 4,981 community-dwelling Medicare beneficiaries from the National Health and Aging Trends Study (NHATS) who had not self-reported a fall in the past 12 months were analyzed...
April 25, 2018: Clinical Gerontologist
Tiffany J Braley, Galit Levi Dunietz, Ronald D Chervin, Lynda D Lisabeth, Lesli E Skolarus, James F Burke
OBJECTIVES: To estimate the proportion of older Americans at risk for obstructive sleep apnea (OSA) who receive OSA evaluations, diagnosis, and treatment. DESIGN: Cross sectional study. SETTING: National Health and Aging Trends Study (NHATS), Round 3 survey. PARTICIPANTS: Community-dwelling Medicare beneficiaries age 65 and older (N=1,052). MEASUREMENTS: NHATS participants were asked specific questions about sleep disturbances, including items that resembled critical elements of a validated instrument used to assess OSA risk (the STOP-Bang questionnaire)...
May 9, 2018: Journal of the American Geriatrics Society
Haidong Bian, Nhat Truong Nguyen, Jeongeun Yoo, Seyedsina Hejazi, Shiva Mohajernia, Julian Müller, Erdmann Spiecker, Hiroaki Tsuchiya, Ondrej Tomanec, Beatriz E Sanabria-Arenas, Radek Zbořil, Yang Yang Li, Patrik Schmuki
Au and Pt do not form homogeneous bulk alloys as they are thermodynamically not miscible. However, we show that anodic TiO2 nanotubes (NTs) can in-situ be uniformly decorated with homogeneous AuPt alloy nanoparticles (NPs) during their anodic growth. For this, a metallic Ti substrate containing low amounts of dissolved Au (0.1 at%) and Pt (0.1 at%) is used for anodizing. The matrix metal (Ti) is converted to oxide while at the oxide/metal interface direct noble metal particle formation and alloying of Au and Pt takes place; continuously these particles are then picked up by the growing nanotube wall...
May 9, 2018: ACS Applied Materials & Interfaces
Kristofer Lasko, Krishna Prasad Vadrevu, Thanh Thi Nhat Nguyen
Air pollution is one of the major environmental concerns in Vietnam. In this study, we assess the current status of air pollution over Hanoi, Vietnam using multiple different satellite datasets and weather information, and assess the potential to capture rice residue burning emissions with satellite data in a cloud-covered region. We used a timeseries of Ozone Monitoring Instrument (OMI) Ultraviolet Aerosol Index (UVAI) satellite data to characterize absorbing aerosols related to biomass burning. We also tested a timeseries of 3-hourly MERRA-2 reanalysis Black Carbon (BC) concentration data for 5 years from 2012-2016 and explored pollution trends over time...
2018: PloS One
Jacqueline M Ho, Nicole H Ducich, Nhat-Quynh K Nguyen, Mark R Opp
Chronic insufficient sleep is a major societal problem and is associated with increased risk of metabolic disease. Hypothalamic inflammation contributes to hyperphagia and weight gain in diet-induced obesity, but insufficient sleep-induced neuroinflammation has yet to be examined in relation to metabolic function. We therefore fragmented sleep of adult male C57BL/6J mice for 18 h daily for 9 days to determine whether sleep disruption elicits inflammatory responses in brain regions that regulate energy balance and whether this relates to glycemic control...
January 2018: Neurobiology of Sleep and Circadian Rhythms
Hoang-Nhat-Phong Vo, Xuan-Thanh Bui, Thanh-Tin Nguyen, Dinh Duc Nguyen, Thanh-Son Dao, Ngoc-Dan-Thanh Cao, Thi-Kim-Quyen Vo
Photobioreactor technology, especially bubble column configuration, employing microalgae cultivation (e.g., Chlorella sp.), is an ideal man-made environment to achieve sufficient microalgae biomass through its strictly operational control. Nutrients, typically N and P, are necessary elements in the cultivation process, which determine biomass yield and productivity. Specifically, N:P ratios have certain effects on microalgae's biomass growth. It is also attractive that microalgae can sequester CO2 by using that carbon source for photosynthesis and, subsequently, reducing CO2 emission...
April 28, 2018: Journal of Environmental Management
Nhat Tai Nguyen, Jaysen Nelayah, Damien Alloyeau, Guillaume Wang, Laurent Piccolo, Pavel Afanasiev, Christian Ricolleau
Many physical properties of nanoparticles (NPs) are driven by their equilibrium shape (ES). Thus, knowing the kinetic and thermodynamic parameters that affect the particle morphology is key for the rational design of NPs with targeted properties. Here, we report on the thermodynamic ES of supported monometallic palladium and bimetallic palladium-gold (Pd-Au) single-crystalline truncated nano-octahedra (TOs) studied using aberration-corrected transmission electron microscopy (TEM). Monometallic palladium and bimetallic Pd62Au38 and Pd43Au57 TOs were grown by pulsed laser deposition on rutile titania (r-TiO2) nanorods exposing mainly (110) facets...
May 9, 2018: Physical Chemistry Chemical Physics: PCCP
Dong Hyuk Kang, Guo Nan Yin, Min Ji Choi, Kang Moon Song, Kalyan Ghatak, Nguyen Nhat Minh, Mi Hye Kwon, Do Hwan Seong, Ji Kan Ryu, Jun Kyu Suh
PURPOSE: Epigenetic modifications, such as histone acetylation/deacetylation and DNA methylation, play a crucial role in the pathogenesis of inflammatory disorders and fibrotic diseases. The aim of this study was to study the differential gene expression of histone deacetylases (HDACs) in fibroblasts isolated from plaque tissue of Peyronie's disease (PD) or normal tunica albuginea (TA) and to examine the anti-fibrotic effect of small interfering RNA (siRNA)-mediated silencing of HDAC7 in fibroblasts derived from human PD plaque...
May 2018: World Journal of Men's Health
Aldo Córdova-Palomera, Tobias Kaufmann, Francesco Bettella, Yunpeng Wang, Nhat Trung Doan, Dennis van der Meer, Dag Alnæs, Jaroslav Rokicki, Torgeir Moberget, Ida Elken Sønderby, Ole A Andreassen, Lars T Westlye
Cognitive and brain development are determined by dynamic interactions between genes and environment across the lifespan. Aside from marker-by-marker analyses of polymorphisms, biologically meaningful features of the whole genome (derived from the combined effect of individual markers) have been postulated to inform on human phenotypes including cognitive traits and their underlying biological substrate. Here, estimates of inbreeding and genetic susceptibility for schizophrenia calculated from genome-wide data-runs of homozygosity (ROH) and schizophrenia polygenic risk score (PGRS)-are analyzed in relation to cognitive abilities (n = 4183) and brain structure (n = 516) in a general-population sample of European-ancestry participants aged 8-22, from the Philadelphia Neurodevelopmental Cohort...
April 27, 2018: European Journal of Human Genetics: EJHG
Mostafa Ebraheem Morra, Ahmed M A Altibi, Somia Iqtadar, Le Huu Nhat Minh, Sameh Samir Elawady, Asma Hallab, Abdelrahman Elshafay, Omer Abedlbagi Omer, Ahmed Iraqi, Purushottam Adhikari, Jonair Hussein Labib, Khaled Mosaad Elhusseiny, Ahmed Elgebaly, Sophie Yacoub, Le Thi Minh Huong, Kenji Hirayama, Nguyen Tien Huy
Since warning signs and signs of severe dengue are defined differently between studies, we conducted a systematic review on how researchers defined these signs. We conducted an electronic search in Scopus to identify relevant articles, using key words including dengue, "warning signs," "severe dengue," and "classification." A total of 491 articles were identified through this search strategy and were subsequently screened by 2 independent reviewers for definitions of any of the warning or severe signs in the 2009 WHO dengue classification...
April 24, 2018: Reviews in Medical Virology
Thomas M Gill, Christianna S Williams
Background: Despite the rich array of data available on seven self-care and mobility activities, a functional outcome measure, which sums the scores across these activities, has not yet been developed or validated for use in the National Health and Aging Trends Study (NHATS). Methods: Using longitudinal data from NHATS, we evaluted 7,609 participants who were living in community settings. Development of the functional outcome measure was guided by the presence of consistent mortality gradients across a 5-category, 4-category, and two 3-category scales for each of the seven activities; while validation was based on predictive accuracy for mortality and concurrent change in physical performance...
April 21, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Motoi Suzuki, Naoko Katsurada, Minh Nhat Le, Norihiro Kaneko, Makito Yaegashi, Naoto Hosokawa, Yoshihito Otsuka, Masahiro Aoshima, Lay Myint Yoshida, Konosuke Morimoto
BACKGROUND: The effectiveness of inactivated influenza vaccine (IIV) against laboratory-confirmed influenza pneumonia in older adults remains to be established. METHODS: Pneumonia patients aged ≥65 years who visited a study hospital in Chiba, Japan, were prospectively enrolled from February 2012 to January 2014. Sputum samples were collected from participants and tested for influenza virus by polymerase chain reaction assays. Influenza vaccine effectiveness (IVE) against laboratory-confirmed influenza pneumonia was estimated by a test-negative design...
May 17, 2018: Vaccine
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