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https://www.readbyqxmd.com/read/27899227/challenges-to-estimating-vaccine-impact-using-hospitalization-data
#1
Cynthia Schuck-Paim, Robert J Taylor, Lone Simonsen, Roger Lustig, Esra Kürüm, Christian A W Bruhn, Daniel M Weinberger
Because the real-world impact of new vaccines cannot be known before they are implemented in national programs, post-implementation studies at the population level are critical. Studies based on analysis of hospitalization rates of vaccine-preventable outcomes are typically used for this purpose. However, estimates of vaccine impact based on hospitalization data are particularly prone to confounding, as hospitalization rates are tightly linked to changes in the quality, access and use of the healthcare system, which often occur simultaneously with introduction of new vaccines...
November 26, 2016: Vaccine
https://www.readbyqxmd.com/read/27878334/equivalent-wear-performance-of-dual-mobility-bearing-compared-with-standard-bearing-in-total-hip-arthroplasty-in-vitro-study
#2
Gaël Gaudin, André Ferreira, Romain Gaillard, Jean Louis Prudhon, Jacques H Caton, Sébastien Lustig
PURPOSE: Osteolysis in total hip arthroplasty (THA) depends on polyethylene wear and dictates the survival of the prosthesis. Dual mobility in THAs, which is claimed to reduce dislocation risk, has very good long-term clinical results. However, little is known about how the liner wears in this design, compared to the standard single mobility model. METHODS: A comparative study looking at wear of a conventional ultra-high-molecular-weight polyethylene liner, using gravimetric measurement, between dual mobility implants and standard implants, was performed on a simulator in accordance with a normed protocol based on the same dimensions, environmental conditions and stresses...
November 22, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27876543/in-utero-and-childhood-ddt-dde-pbde-and-pcbs-exposure-and-sex-hormones-in-adolescent-boys-the-chamacos-study
#3
Brenda Eskenazi, Stephen A Rauch, Rachel Tenerelli, Karen Huen, Nina T Holland, Robert H Lustig, Katherine Kogut, Asa Bradman, Andreas Sjodin, Kim G Harley
Dichlorodiphenyltrichloroethane (DDT), polybrominated diphenyl ether (PBDE) flame retardants, and polychlorinated biphenyls (PCBs) are believed to be endocrine-disrupting chemicals (EDCs) in humans and animals. The purpose of this study is to examine the relationship of in utero and childhood exposure to these purported EDCs and reproductive hormones in adolescent boys who participated in CHAMACOS, an ongoing birth cohort in California's Salinas Valley. We measured o,p'- and p,p'-DDT, p,p'- DDE, PBDEs and PCBs in serum collected from mothers during pregnancy or at delivery and from their sons at 9 years...
November 14, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27853816/total-hip-arthroplasty-using-direct-anterior-approach-and-dual-mobility-cup-safe-and-efficient-strategy-against-post-operative-dislocation
#4
Cécile Batailler, Camdon Fary, Pierre Batailler, Elvire Servien, Philippe Neyret, Sébastien Lustig
AIM: We hypothesize that a dual mobility cup can be safely used via the direct anterior approach, without increasing the risk of complications or incorrect positioning. MATERIALS AND METHODS: This retrospective study compared 201 primary total hip arthroplasties using a dual mobility cup performed via direct anterior approach without a traction table, to 101 arthroplasties performed via posterolateral approach. Implant positioning, function scores, and early complications were recorded...
November 16, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27837501/fungal-grade-reagents-and-materials-for-molecular-analysis
#5
Michael G Lorenz, Michael Lustig, Marina Linow
Fungal DNA is present at very low loads in clinical specimens. Molecular detection by amplification assays generally is a challenge because of a potentially multiple input of contaminating DNA from exogenous sources. Besides airborne, handling and cross-contamination, materials and reagents used in the molecular laboratory can contain microbial DNA which is a long underestimated potential source of false positive results. In this contribution decontamination procedures of materials and reagents and the selection of certified microbial DNA-free components for sample collection, DNA extraction, and PCR amplification are discussed with respect to the aim of building up a reliable molecular system for the diagnosis of fungal organisms at the limit of detection...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27821091/model-estimates-of-the-burden-of-outpatient-visits-attributable-to-influenza-in-the-united-states
#6
Gonçalo Matias, François Haguinet, Roger L Lustig, Laurel Edelman, Gerardo Chowell, Robert J Taylor
BACKGROUND: Although many studies have modelled the national burdens of hospitalizations and deaths due to influenza, few studies have considered the outpatient burden. To fill this gap for the United States (US), we applied traditional statistical modelling approaches to time series derived from large medical claims databases held in the private sector. METHODS: We accessed ICD-9-coded office visit data extracted from Truven Health Analytics' MarketScan Commercial database covering about one third of the US population <65 years during 2001-2009, and Medicare Supplemental data covering about one fifth of US seniors 65+ during 2006-2009...
November 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27812216/hiv-cell-to-cell-spread-results-in-earlier-onset-of-viral-gene-expression-by-multiple-infections-per-cell
#7
Mikaël Boullé, Thorsten G Müller, Sabrina Dähling, Yashica Ganga, Laurelle Jackson, Deeqa Mahamed, Lance Oom, Gila Lustig, Richard A Neher, Alex Sigal
Cell-to-cell spread of HIV, a directed mode of viral transmission, has been observed to be more rapid than cell-free infection. However, a mechanism for earlier onset of viral gene expression in cell-to-cell spread was previously uncharacterized. Here we used time-lapse microscopy combined with automated image analysis to quantify the timing of the onset of HIV gene expression in a fluorescent reporter cell line, as well as single cell staining for infection over time in primary cells. We compared cell-to-cell spread of HIV to cell-free infection, and limited both types of transmission to a two-hour window to minimize differences due to virus transit time to the cell...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27809799/teicoplanin-based-antimicrobial-therapy-in-staphylococcus-aureus-bone-and-joint-infection-tolerance-efficacy-and-experience-with-subcutaneous-administration
#8
Olivier Peeters, Tristan Ferry, Florence Ader, André Boibieux, Evelyne Braun, Anissa Bouaziz, Judith Karsenty, Emmanuel Forestier, Frédéric Laurent, Sébastien Lustig, Christian Chidiac, Florent Valour
BACKGROUND: Staphylococci represent the first etiologic agents of bone and joint infection (BJI), leading glycopeptides use, especially in case of methicillin-resistance or betalactam intolerance. Teicoplanin may represent an alternative to vancomycin because of its acceptable bone penetration and possible subcutaneous administration. METHODS: Adults receiving teicoplanin for S. aureus BJI were included in a retrospective cohort study investigating intravenous or subcutaneous teicoplanin safety and pharmacokinetics...
November 3, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27788312/physician-warnings-in-psychiatry-and-the-risk-of-road-trauma-an-exposure-crossover-study
#9
Andrew J Lustig, Paul A Kurdyak, Deva Thiruchelvam, Donald A Redelmeier
OBJECTIVE: To determine if physician warnings to psychiatric patients alter the subsequent frequency of a motor vehicle crash. A secondary objective was to determine if physician warnings change the subsequent frequency of psychiatric hospitalization. METHODS: Exposure crossover design of 23,145 psychiatric patients diagnosed with ICD-9 schizophrenia (code 295), mood disorder (296), personality disorder (301), or substance use disorder (303, 304) and warned by their physician about driving safety between April 1, 2006, and March 31, 2011...
October 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27779467/travel-related-tick-borne-encephalitis-israel-2006-2014
#10
Eyal Meltzer, Yael Paran, Yaniv Lustig, Shmuel Stienlauf, Miriam Weinberger, Eli Schwartz
During 2006-2014, four tick-borne encephalitis (TBE) cases occurred among Israeli travelers. We calculated TBE incidence at 321.0, 45.0, 13.2, and 7.5 cases/100,000 travelers/year of travel to Sweden, Switzerland, Austria, and Germany, respectively. TBE incidence among travelers to these destinations appears to justify TBE vaccination in accordance with World Health Organization recommendations.
January 15, 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27771429/total-knee-implant-posterior-stabilised-by-a-third-condyle-design-evolution-and-post-operative-complications
#11
R Gaillard, S Lustig, A Peltier, V Villa, E Servien, P Neyret
BACKGROUND: Despite excellent long-term outcomes, posterior stabilisation by a third condyle continues to receive unwarranted criticism regarding patellar complications and instability. HYPOTHESIS: Complication rates with a tri-condylar posterior-stabilised implant are similar to those with other posterior-stabilised prostheses and have diminished over time due to improvements in prosthesis design. MATERIAL AND METHODS: Post-operative complications and revision rates were assessed retrospectively in a prospective cohort of 4189 consecutive patients who had primary total knee arthroplasty (TKA) using a tri-condylar posterior-stabilised implant (Wright-Tornier) and were then followed-up for at least 24 months...
October 19, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27764096/a-large-genome-wide-association-study-of-age-related-hearing-impairment-using-electronic-health-records
#12
Thomas J Hoffmann, Bronya J Keats, Noriko Yoshikawa, Catherine Schaefer, Neil Risch, Lawrence R Lustig
Age-related hearing impairment (ARHI), one of the most common sensory disorders, can be mitigated, but not cured or eliminated. To identify genetic influences underlying ARHI, we conducted a genome-wide association study of ARHI in 6,527 cases and 45,882 controls among the non-Hispanic whites from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. We identified two novel genome-wide significant SNPs: rs4932196 (odds ratio = 1.185, p = 4.0x10-11), 52Kb 3' of ISG20, which replicated in a meta-analysis of the other GERA race/ethnicity groups (1,025 cases, 12,388 controls, p = 0...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27738829/risk-factors-for-tibial-implant-malpositioning-in-total-knee-arthrosplasty-consecutive-series-of-one-thousand-four-hundred-and-seventeen-cases
#13
Romain Gaillard, Simone Cerciello, Sebastien Lustig, Elvire Servien, Philippe Neyret
PURPOSE: Total knee arthroplasty (TKA) malalignment may result in pain and limited range of motion. The present study assessed the influence of different surgeon's and patient's related factors on the post-operative tibial tray coronal alignment. METHODS: The charts and the x-rays of a continuous prospective series of 1417 TKAs operated upon between 1987 and 2015 were retrospectively reviewed. The long-leg AP views were performed at two months post-op and the tibial mechanical angle of the tibial tray was measured...
October 13, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27726251/fast-comprehensive-single-sequence-four-dimensional-pediatric-knee-mri-with-t2-shuffling
#14
Shanshan Bao, Jonathan I Tamir, Jeffrey L Young, Umar Tariq, Martin Uecker, Peng Lai, Weitian Chen, Michael Lustig, Shreyas S Vasanawala
PURPOSE: To develop and clinically evaluate a pediatric knee magnetic resonance imaging (MRI) technique based on volumetric fast spin-echo (3DFSE) and compare its diagnostic performance, image quality, and imaging time to that of a conventional 2D protocol. MATERIALS AND METHODS: A 3DFSE sequence was modified and combined with a compressed sensing-based reconstruction resolving multiple image contrasts, a technique termed T2 Shuffling (T2 Sh). With Institutional Review Board (IRB) approval, 28 consecutive children referred for 3T knee MRI prospectively underwent a standard clinical knee protocol followed by T2 Sh...
October 11, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27687176/the-role-of-patelloplasty-in-total-knee-arthroplasty
#15
Simone Cerciello, Jonathan Robin, Sébastien Lustig, Giulio Maccauro, Thomas J Heyse, Philippe Neyret
INTRODUCTION: Anterior knee pain (AKP) is a frequent complication after total knee arthroplasty (TKA). Patelloplasty, defined as reshaping the patella for optimal tracking in the trochlea, has been proposed to reduce the rate of this complication in patellar retaining implants. Aim of this study was to analyze the available literature regarding the outcomes of patelloplasty and to assess its methodological quality. MATERIALS AND METHODS: A comprehensive review of the English literature was performed using the keywords "total knee arthroplasty", "patelloplasty" and "patellaplasty" with no limit regarding the year of publication...
November 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/27678106/feasibility-of-ferumoxytol-enhanced-neonatal-and-young-infant-cardiac-mri-without-general-anesthesia
#16
Lillian M Lai, Joseph Y Cheng, Marcus T Alley, Tao Zhang, Michael Lustig, Shreyas S Vasanawala
PURPOSE: To assess the feasibility of ferumoxytol-enhanced anesthesia-free cardiac MRI in neonates and young infants for complex congenital heart disease (CHD). MATERIALS AND METHODS: With Institutional Review Board approval, 21 consecutive neonates and young infants (1 day to 11 weeks old; median age of 3 days) who underwent a rapid two-sequence (MR angiography [MRA] and four-dimensional [4D] flow) MRI protocol with intravenous ferumoxytol without sedation (n = 17) or light sedation (n = 4) at 3 Tesla (T) (except one case at 1...
September 28, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27673843/first-report-of-paragangliomas-treated-with-proton-therapy
#17
I Chowdhury, K T Nead, R A Lustig, D Bigelow, M Ruckenstein, K A Cengel, A Lin, M Alonso-Basanta
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27668560/the-central-role-of-physician-leadership-for-driving-change-in-value-based-care-environments
#18
Adam Lustig, Michael Ogden, Robert W Brenner, Jerry Penso, Kimberly D Westrich, Robert W Dubois
BACKGROUND: In 2013, it was reported that about 1 of every 3 U.S. adults has hypertension. Of these 70 million individuals, approximately 50% have their blood pressure under control. Achieving hypertension control, especially in at-risk populations, requires a multipronged approach that includes lifestyle modifications and pharmacological treatment. As provider groups, hospital systems, and integrated delivery networks optimize their care processes to promote population health activities in support of the accountable care organization (ACO) model of care, managing hypertension and other chronic diseases will be essential to their success...
October 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27650011/cognitive-impairment-in-a-subset-of-breast-cancer-patients-following-systemic-therapy-results-from-a-longitudinal-study
#19
Sanne Menning, Michiel B de Ruiter, Jacobien M Kieffer, Joost Agelink van Rentergem, Dick J Veltman, Agnetha Fruijtier, Hester S A Oldenburg, Epie Boven, Suzan van der Meij, Vera Lustig, Monique E M Bos, Willem Boogerd, Liesbeth Reneman, Sanne B Schagen
CONTEXT: Studies indicate adverse effects of breast cancer (BC) and cancer treatment on cognitive function. OBJECTIVES: To investigate the effects of systemic treatment on cognitive performance in BC patients. METHODS: Participants were BC patients scheduled to receive systemic treatment (BC+SYST; n=31), or no systemic treatment (BC; n=24) and no-cancer controls (NC; n=33). Neuropsychological examinations were used to study cognitive performance on 18 tests grouped into 8 cognitive domains, before adjuvant treatment (T1) and six months after chemotherapy (T2), or at similar intervals...
September 17, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/27634265/molecular-simulation-of-the-thermodynamic-structural-and-vapor-liquid-equilibrium-properties-of-neon
#20
Maryna Vlasiuk, Federico Frascoli, Richard J Sadus
The thermodynamic, structural, and vapor-liquid equilibrium properties of neon are comprehensively studied using ab initio, empirical, and semi-classical intermolecular potentials and classical Monte Carlo simulations. Path integral Monte Carlo simulations for isochoric heat capacity and structural properties are also reported for two empirical potentials and one ab initio potential. The isobaric and isochoric heat capacities, thermal expansion coefficient, thermal pressure coefficient, isothermal and adiabatic compressibilities, Joule-Thomson coefficient, and the speed of sound are reported and compared with experimental data for the entire range of liquid densities from the triple point to the critical point...
September 14, 2016: Journal of Chemical Physics
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