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https://www.readbyqxmd.com/read/29337277/compensatory-dopaminergic-cholinergic-interactions-in-conflict-processing-evidence-from-patients-with-parkinson-s-disease
#1
REVIEW
Kamin Kim, Nicolaas I Bohnen, Martijn L T M Müller, Cindy Lustig
Executive functions are complex both in the cognitive operations involved and in the neural structures and functions that support those operations. This complexity makes executive function highly vulnerable to the detrimental effects of aging, brain injury, and disease, but may also open paths to compensation. Neural compensation is often used to explain findings of additional or altered patterns of brain activations by older adults or patient populations compared to young adults or healthy controls, especially when associated with relatively preserved performance...
January 11, 2018: NeuroImage
https://www.readbyqxmd.com/read/29335836/adipogenesis-and-lipid-production-in-adipocytes-subjected-to-sustained-tensile-deformations-and-elevated-glucose-concentration-a-living-cell-scale-model-system-of-diabesity
#2
Maayan Lustig, Amit Gefen, Dafna Benayahu
Adipocyte fate commitment is characterized by morphological changes of fibroblastic pre-adipocyte cells, and specifically by accumulation of lipid droplets (LDs) as part of the adipogenesis metabolism. Formation of LDs indicates the production of triglycerides from glucose through an insulin-regulated glucose internalization process. In obesity, adipocytes typically become insulin resistant, and glucose transport into the cells is impaired, resulting in type 2 diabetes. In the present study, we monitored the adipogenesis in 3T3-L1 cultured cells exposed to high (450 mg/dL hyperglycemia) and low (100 mg/dL physiological) glucose concentrations, in a novel cell culture model system of diabesity...
January 15, 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29315175/biological-therapies-of-the-inner-ear-what-otologists-need-to-consider
#3
Anne G M Schilder, Helen Blackshaw, Thomas Lenarz, Athanasia Warnecke, Lawrence R Lustig, Hinrich Staecker
No abstract text is available yet for this article.
February 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29296864/immune-tolerance-induction-by-nonmyeloablative-haploidentical-hsct-combining-t-cell-depletion-and-posttransplant-cyclophosphamide
#4
Franco Aversa, Esther Bachar-Lustig, Noga Or-Geva, Lucia Prezioso, Sabrina Bonomini, Ilenia Manfra, Alessandro Monti, Chiara Schifano, Yael Zlotnikov-Klionsky, Massimo F Martelli, Gabriella Sammarelli, Maria Sassi, Maurizio Soli, Silvia Giuliodori, Magda Benecchi, Nicola Giuliani, Frank Lohr, Silvia Pratissoli, Yair Reisner
The establishment of safe approaches to attain durable donor-type chimerism and immune tolerance toward donor antigens represents a major challenge in transplantation biology. Haploidentical hematopoietic stem cell transplantation (HSCT) is currently used for cancer therapy either as a T-cell-depleted megadose HSCT following myeloablative conditioning or with T-cell-replete HSCT following nonmyeloablative conditioning (NMAC) and high-dose posttransplant cyclophosphamide (PTCY). The latter approach suffers from a significant rate of chronic graft-versus-host disease (GVHD), despite prolonged immunosuppression...
November 14, 2017: Blood Advances
https://www.readbyqxmd.com/read/29277400/the-cortical-cholinergic-system-contributes-to-the-top-down-control-of-distraction-evidence-from-patients-with-parkinson-s-disease
#5
REVIEW
Kamin Kim, Martijn L T M Müller, Nicolaas I Bohnen, Martin Sarter, Cindy Lustig
Past animal and human studies robustly report that the cholinergic system plays an essential role in both top-down and bottom-up attentional control, as well as other aspects of cognition (see Ballinger et al., 2016 for a recent review). However, current understanding of how two major cholinergic pathways in the human brain (the basal forebrain-cortical pathway, and the brainstem pedunculopontine-thalamic pathway) contribute to specific cognitive functions remains somewhat limited. To address this issue, we examine how individual variation in the integrity of striatal-dopaminergic, thalamic-cholinergic, and cortical-cholinergic pathways (measured using Positron Emission Tomography in patients with Parkinson's disease) was associated with individual variation in the initial goal-directed focus of attention, the ability to sustain attentional performance over time, and the ability to avoid distraction from a highly-salient, but irrelevant, environmental stimulus...
December 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/29224938/subclinical-atherosclerosis-in-pediatric-liver-transplant-recipients-carotid-and-aorta-intima-media-thickness-and-their-predictors
#6
Emily R Perito, Andrew Phelps, Tabitha Vase, Vickie A Feldstein, Robert H Lustig, Philip Rosenthal
OBJECTIVE: To investigate prevalence and predictors of cardiovascular risk in pediatric liver transplant recipients using noninvasive markers of subclinical atherosclerosis: carotid intima-media thickness (cIMT) and aorta intima-media thickness (aIMT). STUDY DESIGN: Cross-sectional study of 88 pediatric liver transplant recipients. The cIMT and aIMT were measured by ultrasound imaging using standardized protocol. RESULTS: Participants were 15...
December 7, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29214134/a-response-to-papatola-and-lustig-s-paper-on-navigating-a-managed-care-peer-review-guidance-for-clinicians-using-applied-behavior-analysis-in-the-treatment-of-children-on-the-autism-spectrum
#7
Julie Kornack, Brandon Herscovitch, Ashley L Williams
In their 2016 article, "Navigating a Managed Care Peer Review: Guidance for Clinicians Using Applied Behavior Analysis [ABA] in the Treatment of Children on the Autism Spectrum," Papatola and Lustig provide an overview of the managed care process, discuss the medical necessity of ABA, and offer guidance to clinicians on how to navigate the managed care peer review process. Given that the authors are employed by a large international health insurance carrier and conduct peer reviews on behalf of that organization, this response seeks to provide guidance from both the clinical and public policy perspectives that reflect best practices in the field of autism treatment...
December 2017: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/29193112/prevalence-of-adult-unilateral-hearing-loss-and-hearing-aid-use-in-the-united-states
#8
Justin S Golub, Frank R Lin, Lawrence R Lustig, Anil K Lalwani
OBJECTIVE: The prevalence of unilateral hearing loss (UHL) in adults has not been well characterized. The objectives of this study are to determine the prevalence of UHL in U.S. adults and its treatment with hearing aids using a nationally representative study. STUDY DESIGN: Cross-sectional national epidemiologic study (n = 6,242). METHODS: Subjects ≥ 18 years old with audiometric testing in the 2005 to 2006, 2009 to 2010, and 2011 to 2012 cycles of the National Health and Nutrition Examination Study were included...
November 29, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29171604/sensitivity-enhanced-detection-of-non-labile-proton-and-carbon-nmr-spectra-on-water-resonances
#9
Mihajlo Novakovic, Ricardo P Martinho, Gregory L Olsen, Michael S Lustig, Lucio Frydman
Chemical exchange saturation transfer (CEST) experiments enhance the NMR signals of labile protons by continuously transferring these protons' saturation to an abundant solvent pool like water. The present study expands these principles by fusing into these experiments homonuclear isotropic mixing sequences, enabling the water-enhanced detection of non-exchangeable species. Further opportunities are opened by the addition of coupling-mediated heteronuclear polarization transfers, which then impose on the water resonance a saturation stemming from non-labile heteronuclear species like (13)C...
November 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29159989/general-phase-regularized-reconstruction-using-phase-cycling
#10
Frank Ong, Joseph Y Cheng, Michael Lustig
PURPOSE: To develop a general phase regularized image reconstruction method, with applications to partial Fourier imaging, water-fat imaging and flow imaging. THEORY AND METHODS: The problem of enforcing phase constraints in reconstruction was studied under a regularized inverse problem framework. A general phase regularized reconstruction algorithm was proposed to enable various joint reconstruction of partial Fourier imaging, water-fat imaging and flow imaging, along with parallel imaging (PI) and compressed sensing (CS)...
November 21, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29151584/towards-off-the-shelf-genetically-modified-t-cells-prolonging-functional-engraftment-in-mice-by-cd8-veto-t-cells
#11
N Or-Geva, R Gidron-Budovsky, L Radomir, Y Edelstein, A K Singh, R Sidlik-Muskatel, E Ophir, E Bachar-Lustig, Y Reisner
Leukemia accepted article preview online, 20 November 2017. doi:10.1038/leu.2017.332.
November 20, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29122410/non-compliance-with-idsa-guidelines-for-patients-presenting-with-methicillin-susceptible-staphylococcus-aureus-prosthetic-joint-infection-is-a-risk-factor-for-treatment-failure
#12
A Bouaziz, I Uçkay, S Lustig, A Boibieux, D Lew, P Hoffmeyer, P Neyret, C Chidiac, T Ferry
OBJECTIVE: The long-term impact of treatment strategies proposed by the IDSA guidelines for patients presenting with methicillin-susceptible S. aureus (MSSA) prosthetic joint infection (PJI) is not well-known. PATIENTS AND METHODS: Retrospective (2000-2010) cohort study including patients presenting with MSSA hip or knee PJI. A univariate Cox analysis was performed to determine if the non-compliance with IDSA surgical guidelines was a risk factor for treatment failure...
November 6, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29119670/open-access-is-there-a-predator-at-the-door
#13
R Chandra, E W Fisher, T M Jones, D W Kennedy, D H Kraus, J H Krouse, M Link, L R Lustig, B W O'Malley, J F Piccirillo, R Ruben, R T Sataloff, S Schwartz, R Sindwani, R J Smith, M G Stewart, P C Weber, D B Welling, R Youngs
No abstract text is available yet for this article.
November 8, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29075453/a-modeling-framework-for-the-establishment-and-spread-of-invasive-species-in-heterogeneous-environments
#14
Audrey Lustig, Susan P Worner, Joel P W Pitt, Crile Doscher, Daniel B Stouffer, Senait D Senay
Natural and human-induced events are continuously altering the structure of our landscapes and as a result impacting the spatial relationships between individual landscape elements and the species living in the area. Yet, only recently has the influence of the surrounding landscape on invasive species spread started to be considered. The scientific community increasingly recognizes the need for broader modeling framework that focuses on cross-study comparisons at different spatiotemporal scales. Using two illustrative examples, we introduce a general modeling framework that allows for a systematic investigation of the effect of habitat change on invasive species establishment and spread...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29058370/proton-therapy-for-pediatric-head-and-neck-malignancies
#15
Jennifer Vogel, Stefan Both, Maura Kirk, Hann-Hsiang Chao, Rochelle Bagatell, Yimei Li, Richard Womer, Naomi Balamuth, Anne Reilly, Goldie Kurtz, Robert Lustig, Zelig Tochner, Christine Hill-Kayser
PURPOSE: Pediatric head and neck malignancies are managed with intensive multimodality therapy. Proton beam therapy (PBT) may reduce toxicity by limiting exposure of normal tissue to radiation. In this study, we report acute toxicities and early outcomes following PBT for pediatric head and neck malignancies. MATERIALS AND METHODS: Between 2010 and 2016, pediatric patients with nonhematologic malignancies of the head and neck were treated with PBT. Clinical and dosimetric data were abstracted from the medical record and treatment planning system with institutional review board approval...
October 23, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29052744/tibiofemoral-joint-congruence-is-lower-in-females-with-acl-injuries-than-males-with-acl-injuries
#16
Antoine Schneider, Salim Si-Mohamed, Robert A Magnussen, Sebastien Lustig, Philippe Neyret, Elvire Servien
PURPOSE: Previous research has demonstrated that women have a higher risk of anterior cruciate ligament (ACL) injury than men. Tibiofemoral articular geometry may play a role in the occurrence of ACL tears. The purpose of this study was to analyze the gender-specific geometric characteristics differences in tibiofemoral morphology in ACL-deficient patients. METHODS: Medial tibial slope (MTS), lateral tibial slope (LTS), medial tibial plateau concavity, medial and lateral femoral condyle convexity, and lateral plateau convexity were analyzed in 276 patients with complete ACL injuries (138 females and 138 males)...
October 20, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29044151/modeling-and-preventing-progressive-hearing-loss-in-usher-syndrome-iii
#17
Ruishuang Geng, Akil Omar, Suhasini R Gopal, Daniel H-C Chen, Ruben Stepanyan, Martin L Basch, Astra Dinculescu, David N Furness, David Saperstein, William Hauswirth, Lawrence R Lustig, Kumar N Alagramam
Usher syndrome type III (USH3) characterized by progressive loss of vision and hearing is caused by mutations in the clarin-1 gene (CLRN1). Clrn1 knockout (KO) mice develop hair cell defects by postnatal day 2 (P2) and are deaf by P21-P25. Early onset profound hearing loss in KO mice and lack of information about the cochlear cell type that requires Clrn1 expression pose challenges to therapeutic investigation. We generated KO mice harboring a transgene, TgAC1, consisting of Clrn1-UTR (Clrn1 cDNA including its 5' and 3' UTR) under the control of regulatory elements (Atoh1 3' enhancer/β-globin basal promoter) to direct expression of Clrn1 in hair cells during development and down regulate it postnatally...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29031650/tigecycline-based-prolonged-salvage-therapy-in-patients-presenting-with-complex-bone-and-joint-infection
#18
J Wach, A Dinh, H Dutronc, O R Sipahi, A Candevir, F Valour, V Zeller, S Lustig, F Laurent, C Chidiac, T Ferry
OBJECTIVES: To assess the clinical experience of tigecycline-based salvage therapy in patients presenting with Bone and Joint Infections (BJI). PATIENTS AND METHODS: Multicenter retrospective cohort study in France and Turkey (2007-2014). RESULTS: Thirty-six patients (age 58.2±17.8 years; 21 men) were included. The most frequently isolated bacteria were Enterobacteriaceae and staphylococci. Tigecycline (50mg BID, mainly in combination (69...
October 12, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29023975/motion-robust-high-resolution-3d-free-breathing-pulmonary-mri-using-dynamic-3d-image-self-navigator
#19
Wenwen Jiang, Frank Ong, Kevin M Johnson, Scott K Nagle, Thomas A Hope, Michael Lustig, Peder E Z Larson
PURPOSE: To achieve motion robust high resolution 3D free-breathing pulmonary MRI utilizing a novel dynamic 3D image navigator derived directly from imaging data. METHODS: Five-minute free-breathing scans were acquired with a 3D ultrashort echo time (UTE) sequence with 1.25 mm isotropic resolution. From this data, dynamic 3D self-navigating images were reconstructed under locally low rank (LLR) constraints and used for motion compensation with one of two methods: a soft-gating technique to penalize the respiratory motion induced data inconsistency, and a respiratory motion-resolved technique to provide images of all respiratory motion states...
October 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29021891/a-good-sugar-d-mannose-suppresses-autoimmune-diabetes
#20
Yun-Bo Shi, Deling Yin
It is well known that too much sugar uptake causes many health problems, including diabetes and obesity (Lustig et al. in Nature 482:27-29, 2012). However, a team of researchers led by Dr. Wanjun Chen of the National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), USA, have recently shown that d-mannose, a naturally occurring C-2 epimer of glucose is likely beneficial to human health. Their studies have revealed that supraphysiological levels of d-mannose that are safely achievable via drinking-water supplementation can be preventive and therapeutic to experimental autoimmune diabetes and asthmatic lung inflammation (Zhang et al...
2017: Cell & Bioscience
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