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https://www.readbyqxmd.com/read/28426902/hepatic-steatosis-after-pediatric-liver-transplant
#1
Emily R Perito, Tabitha Vase, Rageshree Ramachandran, Andrew Phelps, Kuang-Yu Jen, Robert H Lustig, Vickie A Feldstein, Philip Rosenthal
RATIONALE: Hepatic steatosis develops after liver transplant in 30% of adults, and non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in non-transplanted children. However, post-transplant steatosis has been minimally studied in pediatric liver transplant recipients. We explored the prevalence, persistence, and association with chronic liver damage of hepatic steatosis in these children. RESULTS: In this single-center study of pediatric patients transplanted 1988-2015 (n=318), 31% of those with any post-transplant biopsy (n=271) had ≥1 biopsy with steatosis...
April 20, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28402779/mechanisms-pathophysiology-and-management-of-obesity
#2
LETTER
Florian L Stigler, Robert H Lustig, Janet I Ma
No abstract text is available yet for this article.
April 13, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28396931/does-low-constraint-mobile-bearing-knee-prosthesis-give-satisfactory-results-for-severe-coronal-deformities-a-five-to-twelve-year-follow-up-study
#3
Jaroslaw Czekaj, Camdon Fary, Thierry Gaillard, Sebastien Lustig
PURPOSE: Severe varus and valgus knee deformities traditionally are replaced with constrained implants, with a number of disadvantages. We present our results in this challenging group using a low constraint deep-dish mobile bearing implant design. METHODS: One hundred fifty-four patients (170 arthroplasties) who underwent primary TKA using a deep-dish, mobile bearing posterior-stabilized implant for severe varus (HKA < 170°) or valgus (HKA > 190°) deformity between 2004 and 2009 were evaluated at a mean of 6...
April 11, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28381608/sensitivity-and-kinetics-of-a-ns1-based-zika-virus-elisa-in-zika-infected-travelers-from-israel-czech-republic-italy-belgium-germany-and-chile
#4
Yaniv Lustig, Hana Zelena, Giulietta Venturi, Marjan Van Esbroeck, Camilla Rothe, Cecilia Perret, Ravit Koren, Shiri Katz-Likvornik, Ella Mendelson, Eli Schwartz
Serological diagnosis of Zika Virus is challenging due to high cross-reactivity of Zika virus with other flavivirus antibodies. Recently, a Zika-NS1 based ELISA was developed and shown to be highly specific for Zika antibodies detection; however, sensitivity was evaluated for only a small number of confirmed Zika infected patients. In this study we measured the sensitivity and kinetics of Zika IgM and IgG antibodies by the Zika-NS1 based ELISA in 105 samples from 63 returning-travelers infected by Zika virus (proven by PCR or neutralization assay) from Israel, Czech-Republic, Italy, Belgium, Germany and Chile...
April 5, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28321477/total-knee-arthroplasty-after-varus-distal-femoral-osteotomy-vs-native-knee-similar-results-in-a-case-control-study
#5
Romain Gaillard, Timothy Lording, Sebastien Lustig, Elvire Servien, Philippe Neyret
PURPOSE: The aim of this study was to investigate the results of total knee arthroplasty (TKA) performed after varus distal femoral osteotomy (VrDFO), in comparison to a control group of TKAs performed as the primary intervention for arthrosis. Main hypothesis was that the medium term results for the two groups would be similar. METHODS: All TKAs performed after VrDFO were extracted from a single centre, prospective database of 4046 arthroplasties. A case-control study was performed with a control group comprising two TKAs performed as the primary intervention for each TKA after VrDFO, and matched for sex, age at intervention, body mass index, the type of arthrosis and the type of implant...
March 20, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28320361/estimates-of-hospitalization-attributable-to-influenza-and-rsv-in-the-us-during-1997-2009-by-age-and-risk-status
#6
Gonçalo Matias, Robert Taylor, François Haguinet, Cynthia Schuck-Paim, Roger Lustig, Vivek Shinde
BACKGROUND: Estimates of influenza and respiratory syncytial virus (RSV) burden must be periodically updated to inform public health strategies. We estimated seasonal influenza- and RSV-attributable hospitalizations in the US from 1997 to 2009 according to age and risk status (NCT01599390). METHODS: Multiple linear regression modelling was used to attribute hospitalizations to influenza or RSV using virological surveillance and hospitalization data. Hospitalization data were obtained from the US Nationwide Inpatient Sample and virology data were obtained from FluView (Centers for Disease Control and Prevention)...
March 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28280753/mouse-auditory-brainstem-response-testing
#7
Omar Akil, A E Oursler, Kevin Fan, Lawrence R Lustig
The auditory brainstem response (ABR) test provides information about the inner ear (cochlea) and the central pathways for hearing. The ABR reflects the electrical responses of both the cochlear ganglion neurons and the nuclei of the central auditory pathway to sound stimulation (Zhou et al., 2006; Burkard et al., 2007). The ABR contains 5 identifiable wave forms, labeled as I-V. Wave I represents the summated response from the spiral ganglion and auditory nerve while waves II-V represent responses from the ascending auditory pathway...
March 20, 2016: Bio-protocol
https://www.readbyqxmd.com/read/28260693/genomic-deletion-of-git2-induces-a-premature-age-related-thymic-dysfunction-and-systemic-immune-system-disruption
#8
Sana Siddiqui, Ana Lustig, Arnell Carter, Mathavi Sankar, Caitlin M Daimon, Richard T Premont, Harmonie Etienne, Jaana van Gastel, Abdelkrim Azmi, Jonathan Janssens, Kevin G Becker, Yongqing Zhang, William Wood, Elin Lehrmann, James G Martin, Bronwen Martin, Dennis D Taub, Stuart Maudsley
Recent research has proposed that GIT2 (G protein-coupled receptor kinase interacting protein 2) acts as an integrator of the aging process through regulation of 'neurometabolic' integrity. One of the commonly accepted hallmarks of the aging process is thymic involution. At a relatively young age, 12 months old, GIT2(-/-) mice present a prematurely distorted thymic structure and dysfunction compared to age-matched 12 month-old wild-type control (C57BL/6) mice. Disruption of thymic structure in GIT2(-/-) (GIT2KO) mice was associated with a significant reduction in the expression of the cortical thymic marker, Troma-I (cytokeratin 8)...
March 4, 2017: Aging
https://www.readbyqxmd.com/read/28253080/distinct-frontoparietal-networks-underlying-attentional-effort-and-cognitive-control
#9
Anne S Berry, Martin Sarter, Cindy Lustig
We investigated the brain activity patterns associated with stabilizing performance during challenges to attention. Our findings revealed distinct patterns of frontoparietal activity and functional connectivity associated with increased attentional effort versus preserved performance during challenged attention. Participants performed a visual signal detection task with and without presentation of a perceptual-attention challenge (changing background). The challenge condition increased activation in frontoparietal regions including right mid-dorsal/dorsolateral pFC (RPFC), approximating Brodmann's area 9, and superior parietal cortex...
March 2, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28213703/proximal-tibial-bony-and-meniscal-slopes-are-higher-in-acl-injured-subjects-than-controls-a-comparative-mri-study
#10
Ashraf Elmansori, Timothy Lording, Raphaël Dumas, Khalifa Elmajri, Philippe Neyret, Sébastien Lustig
PURPOSE: Increased tibial slope is reported as a risk factor of non-contact anterior cruciate ligament (ACL) injury, but the effect of the soft tissues on slope remains unclear. The primary aims of this study were to compare the tibial bony and soft tissue slopes between patients with and without ACL injury, and to investigate the relationship between the meniscal slopes (MS) and the tibial bony slope. Our hypothesis was that the menisci would correct the inclination of the bony tibial slope towards the horizontal...
February 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28167688/implant-associated-esbl-klebsiella-pneumonia-producing-small-colony-variant-bone-and-joint-infection-in-a-healthy-40-year-old-man
#11
Cécile Ronde-Oustau, Sébastien Lustig, Céline Dupieux, Tristan Ferry
No abstract text is available yet for this article.
February 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28167350/thalamic-cholinergic-innervation-makes-a-specific-bottom-up-contribution-to-signal-detection-evidence-from-parkinson-s-disease-patients-with-defined-cholinergic-losses
#12
Kamin Kim, Martijn L T M Müller, Nicolaas I Bohnen, Martin Sarter, Cindy Lustig
Successful behavior depends on the ability to detect and respond to relevant cues, especially under challenging conditions. This essential component of attention has been hypothesized to be mediated by multiple neuromodulator systems, but the contributions of individual systems (e.g., cholinergic, dopaminergic) have remained unclear. The present study addresses this issue by leveraging individual variation in regionally-specific cholinergic denervation in Parkinson's disease (PD) patients, while controlling for variation in dopaminergic denervation...
April 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/28162663/-421-a-novel-non-opioid-conesnail-peptide-based-analgesic-as-a-therapeutic-alternative-for-the-treatment-of-chronic-pain
#13
J Mercado, M Xu, K Norton, D Peckham, J Posakony, E Tarcha, J Bartron, M Brown, K Lustig, L Manelli, C Ghelardini, B Cheppudira, M Fowler, S Christensen, J McIntosh, S Iadonato
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28160060/does-a-third-condyle-tka-restore-normal-gait-kinematics-in-varus-knees-in-vivo-knee-kinematic-analysis
#14
Dafina Bytyqi, Bujar Shabani, Laurence Cheze, Philippe Neyret, Sebastien Lustig
INTRODUCTION: Patients with knee osteoarthritis tend to modify spatial and temporal parameters during walking to reduce the pain. Total knee arthroplasty (TKA) is considered the gold standard treatment for end-stage knee osteoarthritis. However, reduced physical function of the knee is partly, but apparently not fully, remedied by surgery. The purpose of this study was to investigate the in vivo, three dimensional knee kinematics during gait at the patients with knee osteoarthritis and the influence of "third condyle" psoterior stabilized (PS) total knee arthroplasty on restoration of normal kinematics...
February 3, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28154145/estimating-the-population-level-impact-of-vaccines-using-synthetic-controls
#15
Christian A W Bruhn, Stephen Hetterich, Cynthia Schuck-Paim, Esra Kürüm, Robert J Taylor, Roger Lustig, Eugene D Shapiro, Joshua L Warren, Lone Simonsen, Daniel M Weinberger
When a new vaccine is introduced, it is critical to monitor trends in disease rates to ensure that the vaccine is effective and to quantify its impact. However, estimates from observational studies can be confounded by unrelated changes in healthcare utilization, changes in the underlying health of the population, or changes in reporting. Other diseases are often used to detect and adjust for these changes, but choosing an appropriate control disease a priori is a major challenge. The "synthetic controls" (causal impact) method, which was originally developed for website analytics and social sciences, provides an appealing solution...
February 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28130921/intracellular-growth-of-mycobacterium-tuberculosis-after-macrophage-cell-death-leads-to-serial-killing-of-host-cells
#16
Deeqa Mahamed, Mikael Boulle, Yashica Ganga, Chanelle Mc Arthur, Steven Skroch, Lance Oom, Oana Catinas, Kelly Pillay, Myshnee Naicker, Sanisha Rampersad, Colisile Mathonsi, Jessica Hunter, Gopalkrishna Sreejit, Alexander S Pym, Gila Lustig, Alex Sigal
A hallmark of pulmonary tuberculosis is the formation of macrophage-rich granulomas. These may restrict Mycobacterium tuberculosis (Mtb) growth, or progress to central necrosis and cavitation, facilitating pathogen growth. To determine factors leading to Mtb proliferation and host cell death, we used live cell imaging to track Mtb infection outcomes in individual primary human macrophages. Internalization of Mtb aggregates caused macrophage death, and phagocytosis of large aggregates was more cytotoxic than multiple small aggregates containing similar numbers of bacilli...
January 28, 2017: ELife
https://www.readbyqxmd.com/read/28114671/processed-food-an-experiment-that-failed
#17
Robert H Lustig
No abstract text is available yet for this article.
March 1, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28089583/association-of-prenatal-and-childhood-pbde-exposure-with-timing-of-puberty-in-boys-and-girls
#18
Kim G Harley, Stephen A Rauch, Jonathan Chevrier, Katherine Kogut, Kimberly L Parra, Celina Trujillo, Robert H Lustig, Louise C Greenspan, Andreas Sjödin, Asa Bradman, Brenda Eskenazi
BACKGROUND: Polybrominated diphenyl ether (PBDE) flame retardants are endocrine-disrupting chemicals that exhibit estrogenic and androgenic properties and may affect pubertal timing. METHODS: Study subjects were participants between 1999 and 2013 in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS), a longitudinal cohort study of predominantly Mexican origin families in Northern California. We measured serum concentrations of four PBDEs (BDE-47, -99, -100, -153) in blood collected from mothers during pregnancy (N=263) and their children at age 9years (N=522)...
March 2017: Environment International
https://www.readbyqxmd.com/read/28079113/congenital-hearing-loss
#19
REVIEW
Anna M H Korver, Richard J H Smith, Guy Van Camp, Mark R Schleiss, Maria A K Bitner-Glindzicz, Lawrence R Lustig, Shin-Ichi Usami, An N Boudewyns
Congenital hearing loss (hearing loss that is present at birth) is one of the most prevalent chronic conditions in children. In the majority of developed countries, neonatal hearing screening programmes enable early detection; early intervention will prevent delays in speech and language development and has long-lasting beneficial effects on social and emotional development and quality of life. A diagnosis of hearing loss is usually followed by a search for an underlying aetiology. Congenital hearing loss might be attributed to environmental and prenatal factors, which prevail in low-income settings; congenital infections, particularly cytomegalovirus infection, are also a common risk factor for hearing loss...
January 12, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28060972/-vitamin-d-and-parathyroid-hormone-levels-and-bone-mineral-density-in-patients-undergoing-hematopoietic-cell-transplantation
#20
Pablo Florenzano, Daniel Ernst, Nicole Lustig, Patricio Rojas, Pablo Ramírez, Claudia Campusano
BACKGROUND: Patients undergoing hematopoietic cell transplantation (HCT) are at increased risk of developing osteoporosis. AIM: To determine the frequency and severity of Vitamin D deficiency, secondary hyperparathyroidism and low bone mass in patients undergoing HCT. PATIENTS AND METHODS: Analysis of the database of patients undergoing HCT in our institution in the 2010-2015 period. We searched for patients with measurements of 25-OH vitamin D (25OHD), parathyroid hormone (PTH) and bone densitometry by double beam X ray absorptiometry (DXA) prior and up to one year after HCT...
September 2016: Revista Médica de Chile
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