keyword
https://read.qxmd.com/read/38639095/rapid-molecular-epidemiology-investigations-into-two-recent-measles-outbreaks-in-israel-detected-from-october-2023-to-january-2024
#1
JOURNAL ARTICLE
Efrat Bucris, Victoria Indenbaum, Tal Levin, Yara Kanaaneh, Keren Friedman, Tatyana Kushnir, Rivka Sheffer, Michal Savion, Matanelle Salama, Noa Di-Castro, Kozita Labay, Maya Butera, Baraah Shihada, Zohar Mor, Yaniv Lustig, Neta S Zuckerman
Between late 2023 and early 2024, two measles outbreaks occurred in Israel, each caused by importation of measles virus strains of respective B3 and D8 genotypes. In this study, we validate transmission pathways uncovered by epidemiological investigations using a rapid molecular approach, based on complete measles virus genomes. The presented findings support this rapid molecular approach in complementing conventional contact tracing and highlight its potential for informing public health interventions.
April 2024: Euro Surveillance
https://read.qxmd.com/read/38627149/measles-outbreak-associated-with-a-preschool-setting-among-partially-vaccinated-children-in-the-tel-aviv-district-israel-october-2023
#2
JOURNAL ARTICLE
Rivka Sheffer, Efrat Bucris, Ziva Amitai, Victoria Indenbaum, Yaniv Lustig, Michal Savion, Naama Nuss, Shepherd Roee Singer, Sharon Alroy Preis, Sharon Almagor, Eyal Leshem, Matanelle Salama
In October 2023, the Tel Aviv District was notified of ten cases of measles. The outbreak initiated in a preschool with high vaccination coverage with one dose of MMR vaccine. Serological testing was available for eight patients (six children and two adults). Among the six children vaccinated with one dose of MMR vaccine, primary vaccine failure was demonstrated. Among the adults, secondary vaccine failure was confirmed. The outbreak was successfully contained due to a combination of factors, notably its occurrence within a population characterized by high vaccination coverage in Tel Aviv, during a period of restricted public interactions due to the prevailing state of war in the country...
April 15, 2024: Vaccine
https://read.qxmd.com/read/38626773/the-impact-of-visual-abstracts-compared-to-automated-tweets-on-social-media-in-otology-neurotology
#3
JOURNAL ARTICLE
Caleb J Fan, Alyssa C Hong, Dennis I Bojrab, Lawrence R Lustig, Robert S Hong
OBJECTIVE: To analyze the effect of visual abstracts versus automated tweets on social media participation in Otology & Neurotology. PATIENTS: N/A. INTERVENTIONS: Introduction of visual abstracts developed by the social media editorial team to established automated tweets created by the dlvr.it computer program on the Otology & Neurotology Twitter account. MAIN OUTCOME MEASURES: Twitter analytics including the number of new followers per month, impressions per tweet, and engagements per tweet...
April 16, 2024: Otology & Neurotology
https://read.qxmd.com/read/38614895/lower-body-warming-and-postoperative-temperature-in-cesarean-delivery-under-spinal-anesthesia-a-randomized-controlled-trial
#4
JOURNAL ARTICLE
S Haim, B Cohen, A Lustig, C Greenberger, B Aptekman, C F Weiniger
No abstract text is available yet for this article.
March 21, 2024: International Journal of Obstetric Anesthesia
https://read.qxmd.com/read/38603677/safety-and-immunogenicity-of-booster-vaccination-and-fractional-dosing-with-ad26-cov2-s-or-bnt162b2-in-ad26-cov2-s-vaccinated-participants
#5
JOURNAL ARTICLE
Catherine Riou, Jinal N Bhiman, Yashica Ganga, Shobna Sawry, Frances Ayres, Richard Baguma, Sashkia R Balla, Ntombi Benede, Mallory Bernstein, Asiphe S Besethi, Sandile Cele, Carol Crowther, Mrinmayee Dhar, Sohair Geyer, Katherine Gill, Alba Grifoni, Tandile Hermanus, Haajira Kaldine, Roanne S Keeton, Prudence Kgagudi, Khadija Khan, Erica Lazarus, Jean Le Roux, Gila Lustig, Mashudu Madzivhandila, Siyabulela F J Magugu, Zanele Makhado, Nelia P Manamela, Qiniso Mkhize, Paballo Mosala, Thopisang P Motlou, Hygon Mutavhatsindi, Nonkululeko B Mzindle, Anusha Nana, Rofhiwa Nesamari, Amkele Ngomti, Anathi A Nkayi, Thandeka P Nkosi, Millicent A Omondi, Ravindre Panchia, Faeezah Patel, Alessandro Sette, Upasna Singh, Strauss van Graan, Elizabeth M Venter, Avril Walters, Thandeka Moyo-Gwete, Simone I Richardson, Nigel Garrett, Helen Rees, Linda-Gail Bekker, Glenda Gray, Wendy A Burgers, Alex Sigal, Penny L Moore, Lee Fairlie
We report the safety and immunogenicity of fractional and full dose Ad26.COV2.S and BNT162b2 in an open label phase 2 trial of participants previously vaccinated with a single dose of Ad26.COV2.S, with 91.4% showing evidence of previous SARS-CoV-2 infection. A total of 286 adults (with or without HIV) were enrolled >4 months after an Ad26.COV2.S prime and randomized 1:1:1:1 to receive either a full or half-dose booster of Ad26.COV2.S or BNT162b2 vaccine. B cell responses (binding, neutralization and antibody dependent cellular cytotoxicity-ADCC), and spike-specific T-cell responses were evaluated at baseline, 2, 12 and 24 weeks post-boost...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38600997/optimized-decision-algorithm-for-the-microbiological-diagnosis-of-osteoarticular-infections-in-adults-using-synovial-fluid-samples-a-prospective-study-in-two-french-hospitals-including-423-samples-of-synovial-fluid
#6
JOURNAL ARTICLE
Céline Dupieux, Ghislaine Descours, Paul Verhoeven, Florence Grattard, Yvonne Benito, François Vandenesch, Céline Cazorla, Tristan Ferry, Sébastien Lustig, Bertrand Boyer, Sandrine Boisset, Anne Carricajo, Frédéric Laurent, / Pirla Investigator Group
No consensus exists about the techniques to use for microbiological diagnosis of bone and joint infections (BJIs). The objective herein was to define an algorithm to optimize BJI diagnosis in adults using various bacteriological methods on synovial fluid samples. This prospective multi-center study included 423 synovial fluids collected from adult patients with suspected BJIs. Culture (using five solid media, an enrichment broth, and blood culture bottles), universal 16S rRNA PCR followed by Sanger sequencing, and seven specific bacterial PCRs were systematically performed...
2024: Journal of Bone and Joint Infection
https://read.qxmd.com/read/38574207/remote-delivery-of-psychological-therapies-may-improve-chronic-pain
#7
JOURNAL ARTICLE
D Jason Frasca, Michael Lustig, Soquel Rey
No abstract text is available yet for this article.
March 2024: American Family Physician
https://read.qxmd.com/read/38550376/a-prospective-phase-i-ii-clinical-trial-of-high-dose-proton-therapy-for-chordomas-and-chondrosarcomas
#8
JOURNAL ARTICLE
Sana S Dastgheyb, Alexandra D Dreyfuss, Michael J LaRiviere, Jahan J Mohiuddin, Brian C Baumann, Jacob Shabason, Robert A Lustig, Jay F Dorsey, Alexander Lin, Sean M Grady, Bert W O'Malley, John Y K Lee, Jason G Newman, James M Schuster, Michelle Alonso-Basanta
PURPOSE: The purpose of this study was to evaluate the feasibility and safety of dose-escalated proton beam therapy for treating chordomas and chondrosarcomas of the skull base and spine. Methods: A prospective cohort of 54 patients (42 with chordomas and 12 with chondrosarcomas) was enrolled between 2010 and 2018. The primary endpoints were feasibility and <20% rate of acute grade ≥3 toxicity, and secondary endpoints included cancer-specific outcomes and toxicities. Patients were followed with magnetic resonance imaging or computed tomography at 3-month intervals...
May 2024: Advances in Radiation Oncology
https://read.qxmd.com/read/38542216/role-of-the-gut-microbiota-in-osteoarthritis-rheumatoid-arthritis-and-spondylarthritis-an-update-on-the-gut-joint-axis
#9
REVIEW
Umile Giuseppe Longo, Alberto Lalli, Benedetta Bandini, Roberto de Sire, Silvia Angeletti, Sebastien Lustig, Antonio Ammendolia, Nicolaas Cyrillus Budhiparama, Alessandro de Sire
Dysregulation of the gut microbiota and their metabolites is involved in the pathogenic process of intestinal diseases, and several pieces of evidence within the current literature have also highlighted a possible connection between the gut microbiota and the unfolding of inflammatory pathologies of the joints. This dysregulation is defined as the "gut-joint axis" and is based on the joint-gut interaction. It is widely recognized that the microbiota of the gut produce a variety of compounds, including enzymes, short-chain fatty acids, and metabolites...
March 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38530684/stratifying-disease-progression-in-patients-with-cardiac-attr-amyloidosis
#10
JOURNAL ARTICLE
Adam Ioannou, Francesco Cappelli, Michele Emdin, Christian Nitsche, Simone Longhi, Ahmad Masri, Alberto Cipriani, Mattia Zampieri, Federica Colio, Michael Poledniczek, Aldostefano Porcari, Yousuf Razvi, Alberto Aimo, Giuseppe Vergaro, Laura De Michieli, Muhammad U Rauf, Rishi K Patel, Eugenia Villanueva, Yael Lustig, Lucia Venneri, Ana Martinez-Naharro, Helen Lachmann, Ashutosh Wechalekar, Carol Whelan, Aviva Petrie, Philip N Hawkins, Scott Solomon, Julian D Gillmore, Marianna Fontana
BACKGROUND: Transthyretin cardiac amyloidosis (ATTR-CA) is a progressive cardiomyopathy. The clinical course varies among individuals and there are no established measures to assess disease progression. OBJECTIVES: The goal of this study was to assess the prognostic importance of an increase in N-terminal pro-B-type natriuretic peptide (NT-proBNP) and outpatient diuretic intensification (ODI) as markers of disease progression in a large cohort of patients with ATTR-CA...
March 1, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38530205/management-of-fixed-flexion-contracture-in-primary-total-knee-arthroplasty-recent-systematic-review
#11
JOURNAL ARTICLE
Elliot Sappey-Marinier, Andréa Fernandez, Jobe Shatrov, Cécile Batailler, Elvire Servien, Denis Huten, Sébastien Lustig
INTRODUCTION: This study aimed to systematically review the literature and identify the surgical management strategy for fixed flexion contracture in primary total knee arthroplasty (TKA) surgery, pre-, intra-, and post-operatively. Secondary endpoints were etiologies and factors favoring flexion contracture. MATERIALS AND METHODS: Searches were carried out in November 2023 in several databases (Pubmed, Scopus, Cochrane, and Google Scholar) using the following keywords: "flexion contracture AND TKA", "fixed flexion deformity AND TKA", "posterior capsular release AND TKA", "posterior capsulotomy in TKA", "distal femoral resection AND TKA"...
2024: SICOT-J
https://read.qxmd.com/read/38506977/risk-of-suprascapular-nerve-injury-in-open-trillat-procedure-an-anatomical-study
#12
JOURNAL ARTICLE
Lyliane Ly, John Swan, Riza B Özbek, Elvire Servien, Sebastien Lustig, Stanislas Gunst
PURPOSE: The open Trillat Procedure described to treat recurrent shoulder instability, has a renewed interest with the advent of arthroscopy. The suprascapular nerve (SSN) is theoretically at risk during the drilling of the scapula near the spinoglenoid notch. The purpose of this study was to assess the relationship between the screw securing the coracoid transfer and the SSN during open Trillat Procedure and define a safe zone for the SSN. METHODS: In this anatomical study, an open Trillat Procedure was performed on ten shoulders specimens...
March 20, 2024: Surgical and Radiologic Anatomy: SRA
https://read.qxmd.com/read/38498206/-evolving-indications-for-partial-knee-replacement-new-aspects
#13
REVIEW
Carlo Theus-Steinmann, Sébastien Lustig, Tilman Calliess
BACKGROUND: Partial knee replacement has proven to be an effective therapy for advanced unicompartmental arthrosis of the knee. Despite continuous advancements in implants and surgical techniques over the past decades, the global preference for total knee arthroplasty still persists for historical reasons. OBJECTIVES: This report aims to illuminate advantages and disadvantages of partial knee replacement considering long-term results, the evolution of indication criteria over recent decades and new aspects in patient selection with potential improvements through emerging technologies...
March 18, 2024: Orthopadie (Heidelb)
https://read.qxmd.com/read/38491050/clearance-of-persistent-sars-cov-2-associates-with-increased-neutralizing-antibodies-in-advanced-hiv-disease-post-art-initiation
#14
JOURNAL ARTICLE
Farina Karim, Catherine Riou, Mallory Bernstein, Zesuliwe Jule, Gila Lustig, Strauss van Graan, Roanne S Keeton, Janine-Lee Upton, Yashica Ganga, Khadija Khan, Kajal Reedoy, Matilda Mazibuko, Katya Govender, Kershnee Thambu, Nokuthula Ngcobo, Elizabeth Venter, Zanele Makhado, Willem Hanekom, Anne von Gottberg, Monjurul Hoque, Quarraisha Abdool Karim, Salim S Abdool Karim, Nithendra Manickchund, Nombulelo Magula, Bernadett I Gosnell, Richard J Lessells, Penny L Moore, Wendy A Burgers, Tulio de Oliveira, Mahomed-Yunus S Moosa, Alex Sigal
SARS-CoV-2 clearance requires adaptive immunity but the contribution of neutralizing antibodies and T cells in different immune states is unclear. Here we ask which adaptive immune responses associate with clearance of long-term SARS-CoV-2 infection in HIV-mediated immunosuppression after suppressive antiretroviral therapy (ART) initiation. We assembled a cohort of SARS-CoV-2 infected people in South Africa (n = 994) including participants with advanced HIV disease characterized by immunosuppression due to T cell depletion...
March 15, 2024: Nature Communications
https://read.qxmd.com/read/38453922/human-igg-fc-engineering-for-enhanced-plasma-half-life-mucosal-distribution-and-killing-of-cancer-cells-and-bacteria
#15
JOURNAL ARTICLE
Stian Foss, Siri A Sakya, Leire Aguinagalde, Marta Lustig, Jutamas Shaughnessy, Ana Rita Cruz, Lisette Scheepmaker, Line Mathiesen, Fulgencio Ruso-Julve, Aina Karen Anthi, Torleif Tollefsrud Gjølberg, Simone Mester, Malin Bern, Mitchell Evers, Diane B Bratlie, Terje E Michaelsen, Tilman Schlothauer, Devin Sok, Jayanta Bhattacharya, Jeanette Leusen, Thomas Valerius, Sanjay Ram, Suzan H M Rooijakkers, Inger Sandlie, Jan Terje Andersen
Monoclonal IgG antibodies constitute the fastest growing class of therapeutics. Thus, there is an intense interest to design more potent antibody formats, where long plasma half-life is a commercially competitive differentiator affecting dosing, frequency of administration and thereby potentially patient compliance. Here, we report on an Fc-engineered variant with three amino acid substitutions Q311R/M428E/N434W (REW), that enhances plasma half-life and mucosal distribution, as well as allows for needle-free delivery across respiratory epithelial barriers in human FcRn transgenic mice...
March 7, 2024: Nature Communications
https://read.qxmd.com/read/38442922/eradicating-an-invasive-mammal-requires-local-elimination-and-reduced-reinvasion-from-an-urban-source-population
#16
JOURNAL ARTICLE
Charlotte R Patterson, Audrey Lustig, Philip J Seddon, Deborah J Wilson, Yolanda van Heezik
Invasive mammal eradications are increasingly attempted across large, complex landscapes. Sequentially controlled management zones can be at risk of reinvasion from adjacent uncontrolled areas, and managers must weigh the relative benefits of ensuring complete elimination from a zone or minimizing reinvasion risk. This is complicated in urban areas, where habitat heterogeneity and a lack of baseline ecological knowledge increase uncertainty. We applied a spatial agent-based model to predict the reinvasion of a well-studied species, the brushtail possum (Trichosurus vulpecula), across an urban area onto a peninsula that is the site of an elimination campaign in Aotearoa New Zealand...
March 5, 2024: Ecological Applications
https://read.qxmd.com/read/38423767/preparing-occupational-therapy-students-for-practice-in-rural-areas-a-scoping-review-protocol
#17
JOURNAL ARTICLE
Karen Hayes, Vagner Dos Santos, Nerida Boyd, Bronwyn Connelly, Kim Lustig
INTRODUCTION: Despite greater needs in rural areas, occupational therapists are maldistributed to urban spaces which limits service access and health outcomes for rural people and communities. Preparation of students for rural practice may improve rural workforce recruitment and retention; however, the range and scope of preparation strategies employed by education providers are unclear. This scoping review aims to understand and describe the range of strategies education services use to prepare occupational therapy students for rural practice across the globe...
February 29, 2024: BMJ Open
https://read.qxmd.com/read/38423074/monobloc-dual-mobility-acetabular-component-versus-a-standard-single-mobility-acetabular-component
#18
JOURNAL ARTICLE
Sébastien Lustig, Matthieu Cotte, Constant Foissey, Rhody D Asirvatham, Elvire Servien, Cecile Batailler
AIMS: The benefit of a dual-mobility acetabular component (DMC) for primary total hip arthroplasties (THAs) is controversial. This study aimed to compare the dislocation and complication rates when using a DMC compared to single-mobility (SM) acetabular component in primary elective THA using data collected at a single centre, and compare the revision rates and survival outcomes in these two groups. METHODS: Between 2010 and 2019, 2,075 primary THAs using either a cementless DM or SM acetabular component were included...
March 1, 2024: Bone & Joint Journal
https://read.qxmd.com/read/38418494/integrating-imaging-and-genomic-data-for-the-discovery-of-distinct-glioblastoma-subtypes-a-joint-learning-approach
#19
JOURNAL ARTICLE
Jun Guo, Anahita Fathi Kazerooni, Erik Toorens, Hamed Akbari, Fanyang Yu, Chiharu Sako, Elizabeth Mamourian, Russell T Shinohara, Constantinos Koumenis, Stephen J Bagley, Jennifer J D Morrissette, Zev A Binder, Steven Brem, Suyash Mohan, Robert A Lustig, Donald M O'Rourke, Tapan Ganguly, Spyridon Bakas, MacLean P Nasrallah, Christos Davatzikos
Glioblastoma is a highly heterogeneous disease, with variations observed at both phenotypical and molecular levels. Personalized therapies would be facilitated by non-invasive in vivo approaches for characterizing this heterogeneity. In this study, we developed unsupervised joint machine learning between radiomic and genomic data, thereby identifying distinct glioblastoma subtypes. A retrospective cohort of 571 IDH-wildtype glioblastoma patients were included in the study, and pre-operative multi-parametric MRI scans and targeted next-generation sequencing (NGS) data were collected...
February 28, 2024: Scientific Reports
https://read.qxmd.com/read/38415940/neutrality-normality-abnormality-and-pathology-in-coronal-knee-alignment-why-and-how-should-we-define-it-in-the-era-of-personalised-medicine
#20
EDITORIAL
Michael T Hirschmann, Rüdiger von Eisenhart-Rothe, Heiko Graichen, Pascal-André Vendittoli, Antonia F Chen, Sebastien Lustig, Joan Leal, Carsten Tibesku, Michel Bonnin
No abstract text is available yet for this article.
February 28, 2024: Knee Surgery, Sports Traumatology, Arthroscopy
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