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https://www.readbyqxmd.com/read/29122410/non-compliance-with-idsa-guidelines-for-patients-presenting-with-methicillin-susceptible-staphylococcus-aureus-prosthetic-joint-infection-is-a-risk-factor-for-treatment-failure
#1
A Bouaziz, I Uçkay, S Lustig, A Boibieux, D Lew, P Hoffmeyer, P Neyret, C Chidiac, T Ferry
OBJECTIVE: The long-term impact of treatment strategies proposed by the IDSA guidelines for patients presenting with methicillin-susceptible S. aureus (MSSA) prosthetic joint infection (PJI) is not well-known. PATIENTS AND METHODS: Retrospective (2000-2010) cohort study including patients presenting with MSSA hip or knee PJI. A univariate Cox analysis was performed to determine if the non-compliance with IDSA surgical guidelines was a risk factor for treatment failure...
November 6, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29119670/open-access-is-there-a-predator-at-the-door
#2
R Chandra, E W Fisher, T M Jones, D W Kennedy, D H Kraus, J H Krouse, M Link, L R Lustig, B W O'Malley, J F Piccirillo, R Ruben, R T Sataloff, S Schwartz, R Sindwani, R J Smith, M G Stewart, P C Weber, D B Welling, R Youngs
No abstract text is available yet for this article.
November 8, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29075453/a-modeling-framework-for-the-establishment-and-spread-of-invasive-species-in-heterogeneous-environments
#3
Audrey Lustig, Susan P Worner, Joel P W Pitt, Crile Doscher, Daniel B Stouffer, Senait D Senay
Natural and human-induced events are continuously altering the structure of our landscapes and as a result impacting the spatial relationships between individual landscape elements and the species living in the area. Yet, only recently has the influence of the surrounding landscape on invasive species spread started to be considered. The scientific community increasingly recognizes the need for broader modeling framework that focuses on cross-study comparisons at different spatiotemporal scales. Using two illustrative examples, we introduce a general modeling framework that allows for a systematic investigation of the effect of habitat change on invasive species establishment and spread...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29058370/proton-therapy-for-pediatric-head-and-neck-malignancies
#4
Jennifer Vogel, Stefan Both, Maura Kirk, Hann-Hsiang Chao, Rochelle Bagatell, Yimei Li, Richard Womer, Naomi Balamuth, Anne Reilly, Goldie Kurtz, Robert Lustig, Zelig Tochner, Christine Hill-Kayser
PURPOSE: Pediatric head and neck malignancies are managed with intensive multimodality therapy. Proton beam therapy (PBT) may reduce toxicity by limiting exposure of normal tissue to radiation. In this study, we report acute toxicities and early outcomes following PBT for pediatric head and neck malignancies. MATERIALS AND METHODS: Between 2010 and 2016, pediatric patients with nonhematologic malignancies of the head and neck were treated with PBT. Clinical and dosimetric data were abstracted from the medical record and treatment planning system with institutional review board approval...
October 23, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29052744/tibiofemoral-joint-congruence-is-lower-in-females-with-acl-injuries-than-males-with-acl-injuries
#5
Antoine Schneider, Salim Si-Mohamed, Robert A Magnussen, Sebastien Lustig, Philippe Neyret, Elvire Servien
PURPOSE: Previous research has demonstrated that women have a higher risk of anterior cruciate ligament (ACL) injury than men. Tibiofemoral articular geometry may play a role in the occurrence of ACL tears. The purpose of this study was to analyze the gender-specific geometric characteristics differences in tibiofemoral morphology in ACL-deficient patients. METHODS: Medial tibial slope (MTS), lateral tibial slope (LTS), medial tibial plateau concavity, medial and lateral femoral condyle convexity, and lateral plateau convexity were analyzed in 276 patients with complete ACL injuries (138 females and 138 males)...
October 20, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29044151/modeling-and-preventing-progressive-hearing-loss-in-usher-syndrome-iii
#6
Ruishuang Geng, Akil Omar, Suhasini R Gopal, Daniel H-C Chen, Ruben Stepanyan, Martin L Basch, Astra Dinculescu, David N Furness, David Saperstein, William Hauswirth, Lawrence R Lustig, Kumar N Alagramam
Usher syndrome type III (USH3) characterized by progressive loss of vision and hearing is caused by mutations in the clarin-1 gene (CLRN1). Clrn1 knockout (KO) mice develop hair cell defects by postnatal day 2 (P2) and are deaf by P21-P25. Early onset profound hearing loss in KO mice and lack of information about the cochlear cell type that requires Clrn1 expression pose challenges to therapeutic investigation. We generated KO mice harboring a transgene, TgAC1, consisting of Clrn1-UTR (Clrn1 cDNA including its 5' and 3' UTR) under the control of regulatory elements (Atoh1 3' enhancer/β-globin basal promoter) to direct expression of Clrn1 in hair cells during development and down regulate it postnatally...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29031650/tigecycline-based-prolonged-salvage-therapy-in-patients-presenting-with-complex-bone-and-joint-infection
#7
J Wach, A Dinh, H Dutronc, O R Sipahi, A Candevir, F Valour, V Zeller, S Lustig, F Laurent, C Chidiac, T Ferry
OBJECTIVES: To assess the clinical experience of tigecycline-based salvage therapy in patients presenting with Bone and Joint Infections (BJI). PATIENTS AND METHODS: Multicenter retrospective cohort study in France and Turkey (2007-2014). RESULTS: Thirty-six patients (age 58.2±17.8 years; 21 men) were included. The most frequently isolated bacteria were Enterobacteriaceae and staphylococci. Tigecycline (50mg BID, mainly in combination (69...
October 12, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29023975/motion-robust-high-resolution-3d-free-breathing-pulmonary-mri-using-dynamic-3d-image-self-navigator
#8
Wenwen Jiang, Frank Ong, Kevin M Johnson, Scott K Nagle, Thomas A Hope, Michael Lustig, Peder E Z Larson
PURPOSE: To achieve motion robust high resolution 3D free-breathing pulmonary MRI utilizing a novel dynamic 3D image navigator derived directly from imaging data. METHODS: Five-minute free-breathing scans were acquired with a 3D ultrashort echo time (UTE) sequence with 1.25 mm isotropic resolution. From this data, dynamic 3D self-navigating images were reconstructed under locally low rank (LLR) constraints and used for motion compensation with one of two methods: a soft-gating technique to penalize the respiratory motion induced data inconsistency, and a respiratory motion-resolved technique to provide images of all respiratory motion states...
October 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29021891/a-good-sugar-d-mannose-suppresses-autoimmune-diabetes
#9
Yun-Bo Shi, Deling Yin
It is well known that too much sugar uptake causes many health problems, including diabetes and obesity (Lustig et al. in Nature 482:27-29, 2012). However, a team of researchers led by Dr. Wanjun Chen of the National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH), USA, have recently shown that d-mannose, a naturally occurring C-2 epimer of glucose is likely beneficial to human health. Their studies have revealed that supraphysiological levels of d-mannose that are safely achievable via drinking-water supplementation can be preventive and therapeutic to experimental autoimmune diabetes and asthmatic lung inflammation (Zhang et al...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29020195/impact-of-pneumococcal-conjugate-vaccines-on-pneumonia-hospitalizations-in-high-and-low-income-subpopulations-in-brazil
#10
Joshua L Warren, Kayoko Shioda, Esra Kürüm, Cynthia Schuck-Paim, Roger Lustig, Robert J Taylor, Lone Simonsen, Daniel M Weinberger
Background: Pneumococcal conjugate vaccines (PCVs) are being used worldwide. A key question is whether the impact of PCVs on pneumonia is similar in low- and high-income populations. However, most low-income countries, where the burden of disease is greatest, lack reliable data that can be used to evaluate the impact. Data from middle-income countries that have both low- and high-income subpopulations can provide a proxy measure for the impact of the vaccine in low-income countries. Methods: We evaluated the impact of PCV10 on hospitalizations for all-cause pneumonia in Brazil, a middle-income country with localities that span a broad range of human development index (HDI) levels...
July 22, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28970831/telomere-shortening-inflammatory-cytokines-and-anti-cytomegalovirus-antibody-follow-distinct-age-associated-trajectories-in-humans
#11
Ana Lustig, Hans B Liu, E Jeffrey Metter, Yang An, Melissa A Swaby, Palchamy Elango, Luigi Ferrucci, Richard J Hodes, Nan-Ping Weng
A number of biological parameters have been cited as hallmarks of immune aging. However, it is not clear whether these multiple biological changes are the result of common underlying aging processes and follow correlated trajectories, or whether the patterns of change for multiple parameters vary across individuals and reflect heterogeneity in the aging process. Here, we have studied parameters of immune system aging through longitudinal analysis of telomere length, inflammatory cytokines, and antibody titer to cytomegalovirus (CMV) in 465 subjects ranging in age from 21 to 88 years at the first visit, with an average of 13 years (7-19 years) follow-up...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28970004/intercalary-diaphyseal-endoprosthetic-reconstruction-for-tibial-septic-non-union-in-an-elderly-patient-a-case-report
#12
Y Herry, O Reynaud, T Ferry, E Servien, P Neyret, S Lustig
The surgical treatment of septic non-union is challenging and carries a high failure rate. Bone defect management and fracture site stabilisation are key treatment objectives. We report the case of a 75-year-old woman who underwent intercalary endoprosthetic reconstruction of a large tibial defect due to septic non-union after two previous treatment failures. The two-stage procedure involved extensive excision of infected tissues and implantation of an antibiotic-loaded cement spacer followed by insertion of an intercalary endoprosthesis...
September 29, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28961946/can-a-pharmacokinetic-pharmacodynamic-pkpd-model-be-predictive-across-bacterial-densities-and-strains-external-evaluation-of-a-pkpd-model-describing-longitudinal-in-vitro-data
#13
Elisabet I Nielsen, David D Khan, Sha Cao, Ulrika Lustig, Diarmaid Hughes, Dan I Andersson, Lena E Friberg
Background: Pharmacokinetic/pharmacodynamic (PKPD) models developed based on data from in vitro time-kill experiments have been suggested to contribute to more efficient drug development programmes and better dosing strategies for antibiotics. However, for satisfactory predictions such models would have to show good extrapolation properties. Objectives: To evaluate if a previously described mechanism-based PKPD model was able also to predict drug efficacy for higher bacterial densities and across bacterial strains...
November 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28961767/intraosteoblastic-activity-of-daptomycin-in-combination-with-oxacillin-and-ceftaroline-against-mssa-and-mrsa
#14
Céline Dupieux, Sophie Trouillet-Assant, Caroline Camus, Lélia Abad, Michèle Bes, Yvonne Benito, Christian Chidiac, Sébastien Lustig, Tristan Ferry, Florent Valour, Frédéric Laurent
Background: The Staphylococcus aureus intracellular reservoir is associated with bone and joint infection (BJI) chronicity. As daptomycin is increasingly prescribed in BJI, strategies for improving its reduced intracellular activity should be promoted. Objectives: Based on the known in vitro synergy of daptomycin with β-lactams, the aim of the present study was to evaluate the intracellular activity of these combinations in an ex vivo osteoblast infection model...
September 6, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28951281/outcomes-of-cup-revision-for-ilio-psoas-impingement-after-total-hip-arthroplasty-retrospective-study-of-46-patients
#15
C Batailler, N Bonin, M Wettstein, A Nogier, S Martres, E Ollier, O May, S Lustig
BACKGROUND: Impingement of the ilio-psoas tendon on the acetabular component is a cause of pain after total hip arthroplasty (THA). Studies of cup revision for ilio-psoas impingement (IPI) are scarce and limited in size. We therefore conducted a large multicentre retrospective study with the following objectives: to assess the effectiveness of cup replacement in resolving the impingement syndrome, to determine the frequency and nature of complications after cup revision for IPI, and to identify pre-operative factors associated with good outcomes of cup revision for IPI...
September 22, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28939967/no-influence-of-obesity-on-survival-of-cementless-posterior-stabilised-rotating-platform-implants
#16
Romain Gaillard, Thierry Gaillard, Stephane Denjean, Sebastien Lustig
INTRODUCTION: This study compares survival and outcomes in four total knee arthroplasty (TKA) populations defined by baseline body mass index (BMI). We hypothesised that there would be no difference in survival between the groups. MATERIALS AND METHODS: Using an initial cohort of 1059 TKAs, BMI was systematically measured prior to surgery. A retrospective study was conducted and patients were accordingly allocated to four groups: normal or underweight (BMI < 25; n = 111), overweight (25 ≤ BMI < 30; n = 417), moderately obese (30 ≤ BMI < 35; n = 330) and severely or morbidly obese (BMI ≥ 35; n = 201)...
September 22, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28930008/usutu-virus-rna-in-mosquitoes-israel-2014-2015
#17
Batya Mannasse, Ella Mendelson, Laor Orshan, Orna Mor, Uri Shalom, Tamar Yeger, Yaniv Lustig
We identified Usutu virus (USUV) RNA in 6 pools of mosquitoes trapped in northern Israel during 2014-2015. These Israeli strains were most similar to strains identified in Senegal and Germany, which further elucidates common ancestry and evolutionary dynamics of USUV. Our findings suggest that human infection with USUV might occur in Israel.
October 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28917521/midterm-results-of-combined-intra-and-extra-articular-acl-reconstruction-compared-to-historical-acl-reconstruction-data-multicenter-study-of-the-french-arthroscopy-society
#18
P Imbert, S Lustig, C Steltzlen, C Batailler, P Colombet, F Dalmay, S Bertiaux, P D'ingrado, F P Ehkirch, M L Louis, R Pailhé, J C Panisset, B Schlaterrer, B Sonnery-Cottet, L Sigwalt, D Saragaglia, C Lutz
INTRODUCTION: During anterior cruciate ligament (ACL) reconstruction procedures, anterolateral reconstruction (ALR) can also be performed to improve the knee's rotational stability. However, the effectiveness of this supplemental technique and its impact on the risk of retears and on the onset of secondary degenerative changesare controversial. HYPOTHESIS: ALR improves control over the pivot shift, reduces the retear risk and delays the appearance of secondary degenerative lesions...
September 13, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28917520/short-term-complications-in-intra-and-extra-articular-anterior-cruciate-ligament-reconstruction-comparison-with-the-literature-on-isolated-intra-articular-reconstruction-a-multicenter-study-by-the-french-arthroscopy-society
#19
J C Panisset, R Pailhé, B Schlatterer, L Sigwalt, B Sonnery-Cottet, C Lutz, S Lustig, C Batailler, S Bertiaux, F P Ehkirch, P Colombet, C Steltzlen, M L Louis, P D'ingrado, F Dalmay, P Imbert, D Saragaglia
INTRODUCTION: Lateral tenodesis (LT) is performed to limit the risk of iterative tear following anterior cruciate ligament (ACL) reconstruction in at-risk patients. By adding an extra procedure to isolated ACL graft, LT reconstruction increases operating time and may complicate postoperative course. The objective of the present study was to evaluate the rate of early complications. The study hypothesis was that associating ALL reconstruction to ACL reconstruction does not increase the complications rate found with isolated ACL reconstruction...
September 13, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28913557/improved-joint-line-restitution-in-unicompartmental-knee-arthroplasty-using-a-robotic-assisted-surgical-technique
#20
Yannick Herry, Cécile Batailler, Timothy Lording, Elvire Servien, Philippe Neyret, Sebastien Lustig
PURPOSE: Joint-line restitution is one objective of unicompartmental knee arthroplasty (UKA). However, the joint line is often lowered when resurfacing femoral implants are used. The aim of this study was to compare the joint-line height in UKA performed by robotic-assisted and conventional techniques. METHODS: This retrospective case-control study compared two matched groups of patients receiving a resurfacing UKA between 2013 and 2016 by either a robotic-assisted (n = 40) or conventional (n = 40) technique...
September 14, 2017: International Orthopaedics
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