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https://www.readbyqxmd.com/read/28816148/prompt-gamma-imaging-for-in%C3%A2-vivo-range-verification-of-pencil-beam-scanning-proton-therapy
#1
Yunhe Xie, El Hassane Bentefour, Guillaume Janssens, Julien Smeets, François Vander Stappen, Lucian Hotoiu, Lingshu Yin, Derek Dolney, Stephen Avery, Fionnbarr O'Grady, Damien Prieels, James McDonough, Timothy D Solberg, Robert A Lustig, Alexander Lin, Boon-Keng K Teo
PURPOSE: To report the first clinical results and value assessment of prompt gamma imaging for in vivo proton range verification in pencil beam scanning mode. METHODS AND MATERIALS: A stand-alone, trolley-mounted, prototype prompt gamma camera utilizing a knife-edge slit collimator design was used to record the prompt gamma signal emitted along the proton tracks during delivery of proton therapy for a brain cancer patient. The recorded prompt gamma depth detection profiles of individual pencil beam spots were compared with the expected profiles simulated from the treatment plan...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28808754/three-dimensionalct-analysis-of-femoral-tunnel-position-after-acl-reconstruction-a-prospective-study-of-one-hundred-and-thirty-five-cases
#2
Olivier Reynaud, Cécile Batailler, Timothy Lording, Sebastien Lustig, Elvire Servien, Philippe Neyret
BACKGROUND: One of the principal causes for failure of anterior cruciate ligament reconstruction (ACL) is femoral tunnel mal-position. Several studies compare the position of femoral tunnels achieved with various techniques, with small series and using a quadrant assessment method. QUESTIONS: (1) What is the incidence of anatomical positioning of the intra-articular femoral tunnel aperture in primary ACL reconstruction in a university knee surgery? (2) What are the main errors in positioning? METHODS: 3D-CT scans were performed after primary ACL reconstruction in 135 consecutive cases...
August 14, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28806396/inhibiting-myc-binding-to-the-e-box-dna-motif-by-me47-decreases-tumour-xenograft-growth
#3
L C Lustig, D Dingar, W B Tu, C Lourenco, M Kalkat, I Inamoto, R Ponzielli, W C W Chan, J A Shin, L Z Penn
Developing therapeutics to effectively inhibit the MYC oncoprotein would mark a key advance towards cancer patient care as MYC is deregulated in over 50% of human cancers. MYC deregulation is correlated with aggressive disease and poor patient outcome. Despite strong evidence in mouse models that inhibiting MYC would significantly impact tumour cell growth and patient survival, traditional approaches have not yet yielded the urgently needed therapeutic agents that directly target MYC. MYC functions through its interaction with MAX to regulate gene transcription by binding to E-box DNA response elements of MYC target genes...
August 14, 2017: Oncogene
https://www.readbyqxmd.com/read/28775179/health-and-economic-benefits-of-reducing-sugar-intake-in-the-usa-including-effects-via-non-alcoholic-fatty-liver-disease-a-microsimulation-model
#4
Rick A Vreman, Alex J Goodell, Luis A Rodriguez, Travis C Porco, Robert H Lustig, James G Kahn
OBJECTIVES: Excessive consumption of added sugars in the human diet has been associated with obesity, type 2 diabetes (T2D), coronary heart disease (CHD) and other elements of the metabolic syndrome. Recent studies have shown that non-alcoholic fatty liver disease (NAFLD) is a critical pathway to metabolic syndrome. This model assesses the health and economic benefits of interventions aimed at reducing intake of added sugars. METHODS: Using data from US National Health Surveys and current literature, we simulated an open cohort, for the period 2015-2035...
August 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28767518/bayesian-model-averaging-with-change-points-to-assess-the-impact-of-vaccination-and-public-health-interventions
#5
Esra Kürüm, Joshua L Warren, Cynthia Schuck-Paim, Roger Lustig, Joseph A Lewnard, Rodrigo Fuentes, Christian A W Bruhn, Robert J Taylor, Lone Simonsen, Daniel M Weinberger
BACKGROUND: Pneumococcal conjugate vaccines (PCVs) prevent invasive pneumococcal disease and pneumonia. However, some low- and middle-income countries have yet to introduce PCV into their immunization programs due, in part, to lack of certainty about the potential impact. Assessing PCV benefits is challenging because specific data on pneumococcal disease is often lacking, and it can be difficult to separate the effects of factors other than the vaccine that could also affect pneumococcal disease rates...
July 31, 2017: Epidemiology
https://www.readbyqxmd.com/read/28733109/reconstructing-the-chronically-disrupted-knee-extensor-mechanism-after-total-knee-arthroplasty-hourglass-variant-of-the-original-partial-allograft-technique
#6
C Fiquet, A Schneider, R Ballis, E Servien, P Neyret, S Lustig
Allograft reconstruction is a valuable treatment option for patients with chronic extensor mechanism disruption after total knee arthroplasty. Here, an hourglass variant of the original partial allografttechnique is described. An hourglass-shaped patellar bone block is press-fit into the native patella. The graft is fixed to both the patella and the tibia then sutured with the knee fully extended. Outcomes of this technique were assessed in 5 patients after at least 24 months' follow-up. The mean knee and function Knee Society Score values were 77...
July 18, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28720403/gradenigo-s-syndrome-a-case-of-a-common-infection-with-uncommon-consequences
#7
Matthew Vitale, Misra Amrit, Rajan Arora, Julie Lata
Acute otitis media is a common diagnosis encountered by emergency medicine providers. With appropriate antibiotic treatment, patients with otitis media, in general, have minimal long-term sequela from their underlying infection (Limb et al., 2017 [1]). However, untreated cases can develop life-threatening complications that require prompt intervention. We report a case of an 8-year-old that developed Gradenigo's syndrome, a condition characterized by the triad of otitis media, facial pain in the distribution of the trigeminal nerve, and abducens nerve palsy (Yeung and Lustig, 2016; Janjua et al...
July 5, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28715517/ethical-considerations-for-nutrition-counseling-about-processed-food-reply
#8
Robert H Lustig
No abstract text is available yet for this article.
July 17, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28710265/francisella-like-endosymbionts-and-rickettsia-species-in-local-and-imported-hyalomma-ticks
#9
Tal Azagi, Eyal Klement, Gidon Perlman, Yaniv Lustig, Kosta Y Mumcuoglu, Dmitry Apanaskevich, Yuval Gottlieb
Hyalomma ticks (Acari: Ixodidae) are hosts for Francisella like endosymbionts (FLE) and may serve as vectors of zoonotic disease agents. This study was aimed to provide initial characterization of the interaction between Hyalomma and FLE and to determine the prevalence of pathogenic Rickettsia in these ticks. Hyalomma marginatum, H. rufipes, H. dromedarii, H. aegyptium and H. excavatum ticks, identified morphologically and molecularly, were collected from different hosts and locations, representing the genus distribution in Israel, as well as from migratory birds...
July 14, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28706270/comprehensive-multi-dimensional-mri-for-the-simultaneous-assessment-of-cardiopulmonary-anatomy-and-physiology
#10
Joseph Y Cheng, Tao Zhang, Marcus T Alley, Martin Uecker, Michael Lustig, John M Pauly, Shreyas S Vasanawala
Diagnostic testing often assesses the cardiovascular or respiratory systems in isolation, ignoring the major pathophysiologic interactions between the systems in many diseases. When both systems are assessed currently, multiple modalities are utilized in costly fashion with burdensome logistics and decreased accessibility. Thus, we have developed a new acquisition and reconstruction paradigm using the flexibility of MRI to enable a comprehensive exam from a single 5-15 min scan. We constructed a compressive-sensing approach to pseudo-randomly acquire highly subsampled, multi-dimensionally-encoded and time-stamped data from which we reconstruct volumetric cardiac and respiratory motion phases, contrast-agent dynamics, and blood flow velocity fields...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28681719/an-outbreak-of-dengue-virus-denv-type-2-cosmopolitan-genotype-in-israeli-travellers-returning-from-the-seychelles-april-2017
#11
Yaniv Lustig, Dana Wolf, Ora Halutz, Eli Schwartz
Dengue virus infection was diagnosed in six Israeli travellers returning from the Seychelles in April 2017. Phylogenetic analysis identified identical sequences belonging to the Cosmopolitan genotype of dengue virus type 2 in all samples sequenced, thus providing evidence for a probable dengue type 2 outbreak in the Seychelles. This report further demonstrates the role of travellers as sentinels for arboviral infections, especially in countries with limited diagnostic capabilities.
June 29, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28629943/arthroscopically-assisted-fixation-is-a-reliable-option-for-patellar-fractures-a-literature-review
#12
REVIEW
Simone Cerciello, Mark Cote, Sébastien Lustig, Felix Dyrna, Leo Pauzenberger, Philippe Neyret, Augustus D Mazzocca
BACKGROUND: Proper reduction and stable fixation of articular fractures is essential for an early recovery and to avoid late complications. Arthroscopically assisted techniques for minimally invasive fixation have been introduced to reduce local morbidity and improve anatomic reduction of the fragments. However up to date no clear indications for surgery have been given. In addition, the precise rates of functional outcomes and complications are controversial. The hypothesis was the systematic analysis of the available literature would provide precise indications, outcomes and complications of arthroscopically assisted techniques for patellar fracture fixation...
June 16, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28628400/west-nile-virus-seroprevalence-in-animals-in-palestine-and-israel
#13
Kifaya Azmi, Sharon Tirosh-Levy, Mu'taz Manasrah, Rotem Mizrahi, Abed Nasereddin, Amer Al-Jawabreh, Suheir Ereqat, Ziad Abdeen, Yaniv Lustig, Boris Gelman, Gili Schvartz, Amir Steinman
West Nile virus (WNV) epidemiological situation in Israel and Palestine, due to their unique location, draws attention following to the global spread of West Nile fever (WNF). Although much information is available from Israel on clinical cases and prevalence of WNV, clinical cases are rarely reported in Palestine, and prevalence is not known. The objectives of this study were to determine WNV seroprevalence in various domestic animals in Palestine and to reevaluate current seroprevalence, force of infection, and risk factors for WNV exposure in horses in Israel...
August 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28625523/induction-treatment-and-prevention-of-eczema-vaccinatum-in-atopic-dermatitis-mouse-models
#14
Hagit Achdout, Shlomo Lustig, Tomer Israely, Noam Erez, Boaz Politi, Hadas Tamir, Ofir Israeli, Trevor Waner, Sharon Melamed, Nir Paran
Eczema vaccinatum is a severe and occasionally lethal complication of smallpox vaccine, characterized by systemic viral dissemination, distant from the initial inoculation site of the vaccine. A major risk factor for eczema vaccinatum is a background of atopic dermatitis, a chronic, common allergic, relapsing disorder, manifested by dry and inflamed skin, itchy rash, Th2 biased immune response and hypersensitivity to various antigens. Unlike the severe manifestations of eczema vaccinatum in humans, current models present only mild symptoms that limits examination of potential therapeutics for eczema vaccinatum...
June 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28622360/the-seroprevalence-of-west-nile-virus-in-israel-a-nationwide-cross-sectional-study
#15
Ravit Bassal, Tamy Shohat, Zalman Kaufman, Batya Mannasse, Eilat Shinar, Doron Amichay, Mira Barak, Anat Ben-Dor, Adina Bar Haim, Daniel Cohen, Ella Mendelson, Yaniv Lustig
West Nile Virus (WNV) is endemic in Israel, affecting yearly 40-160 individuals. Israel is located on a central migratory path between Africa and Eurasia and most West Nile Fever (WNF) cases reported in recent years were among residents of the coastal plain. The aim of the study was to evaluate the seroprevalence of WNV among the Israeli population and to assess correlates for WNV infection. A cross-sectional nationwide serologic survey was conducted using 3,145 serum samples collected by the national Israeli serum bank during 2011-2014, representing all age and population groups in Israel...
2017: PloS One
https://www.readbyqxmd.com/read/28579536/effects-of-dietary-fructose-restriction-on-liver-fat-de-novo-lipogenesis-and-insulin-kinetics-in-children-with-obesity
#16
Jean-Marc Schwarz, Susan M Noworolski, Ayca Erkin-Cakmak, Natalie J Korn, Michael J Wen, Viva W Tai, Grace M Jones, Sergiu P Palii, Moises Velasco-Alin, Karen Pan, Bruce W Patterson, Alejandro Gugliucci, Robert H Lustig, Kathleen Mulligan
BACKGROUND & AIMS: Consumption of sugar is associated with obesity, type 2 diabetes mellitus, nonalcoholic fatty liver disease, and cardiovascular disease. The conversion of fructose to fat in liver (de novo lipogenesis [DNL]) may be a modifiable pathogenetic pathway. We determined the effect of 9 days of isocaloric fructose restriction on DNL, liver fat, visceral fat (VAT), subcutaneous fat, and insulin kinetics in obese Latino and African American children with habitual high sugar consumption (fructose intake >50 g/d)...
June 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28575907/correction-of-tibial-valgus-deformity
#17
Simone Cerciello, Sebastien Lustig, Elvire Servien, Cecile Batailler, Philippe Neyret
No abstract text is available yet for this article.
June 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28557445/discovery-of-the-soluble-guanylate-cyclase-stimulator-vericiguat-bay-1021189-for-the-treatment-of-chronic-heart-failure
#18
Markus Follmann, Jens Ackerstaff, Gorden Redlich, Frank Wunder, Dieter Lang, Armin Kern, Peter Fey, Nils Griebenow, Walter Kroh, Eva-Maria Becker-Pelster, Axel Kretschmer, Volker Geiss, Volkhart Li, Alexander Straub, Joachim Mittendorf, Rolf Jautelat, Hartmut Schirok, Karl-Heinz Schlemmer, Klemens Lustig, Michael Gerisch, Andreas Knorr, Hanna Tinel, Thomas Mondritzki, Hubert Trübel, Peter Sandner, Johannes-Peter Stasch
The first-in-class soluble guanylate cyclase (sGC) stimulator riociguat was recently introduced as a novel treatment option for pulmonary hypertension. Despite its outstanding pharmacological profile, application of riociguat in other cardiovascular indications is limited by its short half-life, necessitating a three times daily dosing regimen. In our efforts to further optimize the compound class, we have uncovered interesting structure-activity relationships and were able to decrease oxidative metabolism significantly...
June 22, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28556180/multiple-coil-k-space-interpolation-enhances-resolution-in-single-shot-spatiotemporal-mri
#19
Gilad Liberman, Eddy Solomon, Michael Lustig, Lucio Frydman
PURPOSE: Spatio-temporal encoding (SPEN) experiments can deliver single-scan MR images without folding complications and with robustness to chemical shift and susceptibility artifacts. Further resolution improvements are shown to arise by relying on multiple receivers, to interpolate the sampled data along the low-bandwidth dimension. The ensuing multiple-sensor interpolation is akin to recently introduced SPEN interleaving procedures, albeit without requiring multiple shots. METHODS: By casting SPEN's spatial rasterization in k-space, it becomes evident that local k-data interpolations enabled by multiple receivers are akin to real-space interleaving of SPEN images...
May 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28555707/components-and-indicators-of-frailty-measures-a-literature-review
#20
B Xie, J L Larson, R Gonzalez, S J Pressler, C Lustig, C Arslanian-Engoren
BACKGROUND: Frailty is a debilitating condition in older adults that is associated with increased risks for adverse outcomes. However, the issue of quantifying frailty remains elusive. There is a lack of consistency in the frailty components and the corresponding indicators used to quantify these components. OBJECTIVE: 1) to describe the components of frailty and examine the existing measures of frailty; and 2) to identify current gaps in knowledge of frailty measures...
2017: Journal of Frailty & Aging
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