Asmae Squalli Houssaini, Salma Lamrabet, Nadia Senhaji, Mohammed Sekal, Jean Paul Nshizirungu, Hajar Mahfoudi, Samira Elfakir, Mehdi Karkouri, Sanae Bennis
INTRODUCTION: Glioblastoma and astrocytoma, grade 4, are the most common and aggressive brain tumors. Several biomarkers, such as the isocitrate dehydrogenase mutation (IDH-1), alpha-thalassemia/mental retardation, and the X-linked mutation (ATRX), enable more accurate glioma classification and facilitate patient management. This study aimed to determine the prognostic value of clinical and molecular factors (IDH, TP53, and ATRX mutations). We also studied the relationship between these molecular markers and the overall survival (OS) of 126 patients with grade 4 glioblastoma/astrocytoma...
March 2024: Curēus