keyword
https://read.qxmd.com/read/38533659/relation-between-the-relative-abundance-and-collapse-of-aphanizomenon-flos-aquae-and-microbial-antagonism-in-upper-klamath-lake-oregon
#21
JOURNAL ARTICLE
J C Underwood, N C Hall, A C Mumford, R W Harvey, P A Bliznik, K M Jeanis
Aphanizomenon flos-aquae (AFA) is the dominant filamentous cyanobacterium that develops into blooms in Upper Klamath Lake, Oregon each year. During AFA bloom and collapse, ecosystem conditions for endangered Lost River and shortnose suckers deteriorate, thus motivating the need to identify processes that limit AFA abundance and decline. Here we investigate the relations between AFA and other members of the microbial community (photosynthetic and non-photosynthetic bacteria and archaea), how those relations impact abundance and collapse of AFA, and the types of microbial conditions that suppress AFA...
March 26, 2024: FEMS Microbiology Ecology
https://read.qxmd.com/read/38533399/phyllosphere-bacterial-community-dynamics-in-response-to-bacterial-wildfire-disease-succession-and-interaction-patterns
#22
JOURNAL ARTICLE
Deyuan Peng, Zhenhua Wang, Jinyan Tian, Wei Wang, Shijie Guo, Xi Dai, Huaqun Yin, Liangzhi Li
Plants interact with complex microbial communities in which microorganisms play different roles in plant development and health. While certain microorganisms may cause disease, others promote nutrient uptake and resistance to stresses through a variety of mechanisms. Developing plant protection measures requires a deeper comprehension of the factors that influence multitrophic interactions and the organization of phyllospheric communities. High-throughput sequencing was used in this work to investigate the effects of climate variables and bacterial wildfire disease on the bacterial community's composition and assembly in the phyllosphere of tobacco ( Nicotiana tabacum L...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38533397/initiation-and-up-titration-of-guideline-directed-medical-therapy-for-patients-with-heart-failure-better-faster-stronger
#23
REVIEW
Edgar Francisco Carrizales-Sepúlveda, Alejandro Ordaz-Farías, José Arturo Vargas-Mendoza, Raymundo Vera-Pineda, Ramiro Flores-Ramírez
Treatment for heart failure has experienced a major revolution in recent years, and current evidence shows that a combination of four medications (angiotensin receptor-neprilysin inhibitors + β-blockers + mineralocorticoid receptor antagonists + sodium.glucose cotransporter 2 inhibitors) offer the greatest benefit to our patients with significant reductions in cardiovascular mortality, heart failure hospitalisations and all-cause mortality. Unfortunately, despite their proven benefits, the implementation of these therapies is still low...
2024: Cardiac Failure Review
https://read.qxmd.com/read/38533375/comparative-efficacy-of-combined-antihistamine-and-montelukast-therapy-in-adult-patients-with-atopic-dermatitis
#24
JOURNAL ARTICLE
Kristina R Jamalyan, Helen G Azaryan
INTRODUCTION: Atopic dermatitis (AD) is one of the most common chronic skin conditions affecting about 20% of children and 5% of adults. However, the studies assessing novel therapies for AD have been focused mainly on paediatric patients and only few studies have involved adult participants. AIM: To compare the treatment outcomes between the antihistamine monotherapy and combined intervention with an antihistamine agent and a cysteinyl leukotriene receptor antagonist in adult patients with atopic dermatitis...
February 2024: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/38533328/evaluation-of-the-control-efficacy-of-antagonistic-bacteria-from-v-ti-magnetite-mine-tailings-on-kiwifruit-brown-spots-in-pot-and-field-experiments
#25
JOURNAL ARTICLE
Yongliang Cui, Yuhang Zhu, Guanyong Dong, Yanmei Li, Jing Xu, Zuqiang Cheng, Lijun Li, Guoshu Gong, Xiumei Yu
Seemingly barren heavy-metal-polluted vanadium (V) and titanium (Ti) magnetite mine tailings contain various functional microbes, yet it is unclear whether this includes microbial resources relevant to the biological control of plant diseases. Kiwifruit brown leaf spot disease, caused by Corynespora cassiicola , can seriously reduce kiwifruit yield. To discover effective control measures for kiwifruit leaf spot, 18 bacteria strains among 136 tailing-isolated bacteria from V-Ti magnetite mine tailings were identified as inhibiting C...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38533299/vkorc1-polymorphisms-and-complete-resistance-to-vitamin-k-antagonists-about-two-cases
#26
Ilham Benyamna, Houda El Fissi, Fadoua Bouzid, Abdelhamid El Mousadik, Najat Alif
Complete resistance to vitamin K antagonists is a rare but serious condition. It can complicate therapeutic management, especially when direct oral anticoagulants cannot be used. Some single mutations in the VKORC1 gene have been identified in patients partially or completely resistant to vitamin K antagonists. We report the cases of two women in their fifties who presented an unexplained peripheral venous thrombosis. The aetiological assessment did not show any abnormalities. Genetic testing showed that both patients had the VKORC1 5417 GG genotype...
2024: BioMedicine
https://read.qxmd.com/read/38533274/risankizumab-efficacy-in-synovitis-acne-pustulosis-hyperostosis-and-osteitis-sapho-remission-a-case-report-on-rheumatologic-and-dermatologic-disease-manifestations-with-literature-review
#27
Mario Ferraioli, Luigi Fiannacca, Elisabetta Greco, Eneida Cela, Mauro Fatica, Alberto Bergamini, Maria Sole Chimenti
SAPHO syndrome is a complex disease that encompasses both inflammatory arthritis and/or osteitis and dermatologic manifestations. It is considered a rare disease, in fact, no clinical trials have been conducted on its therapy and management. Therefore, therapeutic approach is based on small case studies. Here, we described the case of a 63-year-old woman affected by SAPHO syndrome, treated with the selective IL-23p19 antagonist, Risankizumab, after unsuccessful therapies with Methotrexate, Infliximab, Adalimumab, and an allergic reaction to Secukinumab...
2024: Case Reports in Immunology
https://read.qxmd.com/read/38533144/successful-fluid-management-in-respiratory-failure-due-to-clazosentan-following-a-cerebral-aneurysm-clipping-a-case-report
#28
Hirotaka Kinoshita, Kodai Kato, Yuma Yamazaki, Eiji Hashiba, Kazuyoshi Hirota
Clazosentan, a potent selective endothelin receptor subtype A antagonist, has been demonstrated to be effective in preventing cerebral vasospasms after subarachnoid hemorrhage. We report the successful management of respiratory failure due to pulmonary edema associated with clazosentan, with a hemodynamic monitoring system. A 49-year-old Japanese man underwent emergency clipping for a right internal carotid-posterior communicating artery aneurysm. The surgery and general anesthesia for the rupture proceeded with no complications...
February 2024: Curēus
https://read.qxmd.com/read/38533097/-in-silico-identification-of-multi-target-inhibitors-from-medicinal-fungal-metabolites-against-the-base-excision-repair-pathway-proteins-of-african-swine-fever-virus
#29
JOURNAL ARTICLE
Mark Andrian B Macalalad, Fredmoore L Orosco
African swine fever virus (ASFV) has emerged as a serious threat to the pork industry resulting in significant economic losses and heightened concerns about food security. With no known cure presently available, existing control measures center on animal quarantine and culling. Considering the severity and challenges posed by ASFV, it is imperative to discover new treatment strategies and implement additional measures to prevent its further spread. This study recognized the potential of 1830 fungal metabolites from medicinal fungi as antiviral compounds against base excision repair (BER) proteins of ASFV, specifically ASFV AP, ASFV PolX, and ASFV Lig...
March 20, 2024: RSC Advances
https://read.qxmd.com/read/38532938/real-world-data-on-treatment-patterns-and-bleeding-in-cancer-associated-thrombosis-data-from-the-troll-registry
#30
JOURNAL ARTICLE
Zygimantas Zaboras, Camilla Tøvik Jørgensen, Andreas Stensvold, Heidi Hassel Pettersen, Aleksandra Galovic Grdinic, Sigrid Kufaas Brækkan, Waleed Ghanima, Mazdak Tavoly
Background  International guidelines are increasingly recommending direct oral anticoagulants (DOACs) as the first-line treatment for cancer-associated thrombosis (CAT). However, data regarding treatment patterns and adherence to guidelines in patients with CAT are scarce. Objectives  This study aimed to explore anticoagulant treatment patterns in patients with CAT and to calculate the incidence rates of bleeding events. Methods  Patients ≥18 years with active cancer and a first-time venous thromboembolism between 2005 and 2020 were identified through the Venous T hrombosis R egistry in Østf OL d Hospita L ...
January 2024: TH Open: Companion Journal to Thrombosis and Haemostasis
https://read.qxmd.com/read/38532644/cotton-blh1-and-knox6-antagonistically-modulate-fiber-elongation-via-the-regulation-of-linolenic-acid-biosynthesis
#31
JOURNAL ARTICLE
Tingting Jia, Huiqin Wang, Shiyan Cui, Zihan Li, Yongcui Shen, Hongbin Li, Guanghui Xiao
BEL1-LIKE HOMEODOMAIN (BLH) proteins are known to function in various plant developmental processes. However, the role of BLHs in regulating plant cell elongation is still unknown. Here, we identified a BLH gene, GhBLH1, that positively regulates fiber cell elongation. Combined transcriptomic and biochemical analyses revealed that GhBLH1 enhances linolenic acid accumulation to promote cotton fiber cell elongation by activating the transcription of GhFAD7A-1 via the binding of the POX domain of GhBLH1 to the TGGA cis-element in the GhFAD7A-1 promoter...
March 25, 2024: Plant communications
https://read.qxmd.com/read/38532262/binding-affinity-selectivity-and-pharmacokinetics-of-the-oxytocin-receptor-antagonist-l-368-899-in-the-coyote-canis-latrans
#32
JOURNAL ARTICLE
Sara M Freeman, J Leon Catrow, James Eric Cox, Alexandra Turano, McKenna A Rich, Hillary P Ihrig, Naveena Poudyal, Cheng-Wei Tom Chang, Eric M Gese, Julie K Young, Aaron L Olsen
L-368,899 is a selective small-molecule oxytocin receptor (OXTR) antagonist originally developed in the 1990s to prevent preterm labor. Although its utility for that purpose was limited, L-368,899 is now one of the most commonly used drugs in animal research for the selective blockade of neural OXTR after peripheral delivery. A growing number of rodent and primate studies have used L-368,899 to evaluate whether certain behaviors are oxytocin dependent. These studies have improved our understanding of oxytocin's function in the brains of rodents and monkeys, but very little work has been done in other mammals, and only a single paper in macaques has provided any evidence that L-368,899 can be detected in the CNS after peripheral delivery...
February 1, 2024: Comparative Medicine
https://read.qxmd.com/read/38532020/contemporary-pharmacological-treatment-and-management-of-heart-failure
#33
REVIEW
Biykem Bozkurt
The prevention and treatment strategies for heart failure (HF) have evolved in the past two decades. The stages of HF have been redefined, with recognition of the pre-HF state, which encompasses asymptomatic patients who have developed either structural or functional cardiac abnormalities or have elevated plasma levels of natriuretic peptides or cardiac troponin. The first-line treatment of patients with HF with reduced ejection fraction includes foundational therapies with angiotensin receptor-neprilysin inhibitors, angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, β-blockers, mineralocorticoid receptor antagonists, sodium-glucose cotransporter 2 (SGLT2) inhibitors and diuretics...
March 26, 2024: Nature Reviews. Cardiology
https://read.qxmd.com/read/38531640/-initial-characterization-of-a-transgenic-mouse-with-overexpression-of-the-human-h-1-histamine-receptor-on-the-heart
#34
JOURNAL ARTICLE
Lina Maria Rayo Abella, Hannes Jacob, Max Keller, Lisa Schindler, Steffen Pockes, Sebastian Pitzl, Jan Klimas, Katarina Hadova, Sarah Schneider, Igor B Buchwalow, CongYu Jin, Pertti Panula, Uwe Kirchhefer, Joachim Neumann, Ulrich Gergs
There is controversy whether H1 -histamine receptors increase or decrease contractility in the mammalian heart. Therefore, we have generated mice that overexpress the human H1 -histamine receptor in the heart (H1 -TG). We hypothesized that histamine would either increase or decrease force of contraction and beating rate compared to littermate wild type mice (WT). In H1 -TG mice, we ascertained the presence of H1 -histamine receptors by autoradiography of atrium and ventricle using [3 H]mepyramine. The messenger RNA for human H1 -histamine-receptors was present in cardiac samples from H1 -TG and absent from WT...
March 26, 2024: Journal of Pharmacology and Experimental Therapeutics
https://read.qxmd.com/read/38531587/challenges-and-lessons-learned-from-a-long-term-postauthorisation-safety-study-programme-of-rivaroxaban-in-europe
#35
REVIEW
Gunnar Brobert, Ana Ruigomez, Tania Schink, Annemarie Voss, Ron Herings, Elisabeth Smits, Karin M A Swart, Leif Friberg, Yanina Balabanova, Christine Tarenz, Kiliana Suzart-Woischnik, Montse Soriano-Gabarró, Pareen Vora, Martin Homering, Tomasz Dyszynski, Gerd Nagel, Pablo Amaya, Luis Alberto García Rodríguez
OBJECTIVES: To describe opportunities and challenges experienced from the four pharmacoepidemiological database studies included in the rivaroxaban post authorisation safety study (PASS) programme and propose ways to maximise the value of population-based observational research when addressing regulatory requirements. DESIGN: PASS programme of rivaroxaban carried out as part of the regulatory postapproval commitment to the European Medicines Agency. SETTING: Clinical practice in Germany, the Netherlands, Sweden and the UK (electronic health records)-undertaken by pharmacoepidemiology research teams using country-specific databases with different coding structures...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531422/h2-antihistamines-may-be-useful-for-combination-therapies-in-cancer
#36
REVIEW
Nora A Mohamad, Tamara E Galarza, Gabriela A Martín
Cancer morbimortality is still a great concern despite advances in research and therapies. Histamine and its receptors' ligands can modulate different biological responses according to the cell type and the receptor subtype involved. Besides the wide variety of histamine functions in normal tissues, diverse roles in the acquisition of hallmarks of cancer such as sustained proliferative signaling, resistance to cell death, angiogenesis, metastasis, altered immunity and modified microenvironment have been described...
March 24, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38531285/corrigendum-to-govanosides-c-f-unprecedented-steroidal-saponins-with-rare-sugars-from-rhizomes-of-trillium-govanianum-and-their-antagonistic-effects-on-acetylcholinesterase-steroids-199-2023-109293
#37
Prithvi Pal Singh, Patil Shivprasad Suresh, Anmol, Upendra Sharma
No abstract text is available yet for this article.
March 25, 2024: Steroids
https://read.qxmd.com/read/38531261/developmental-programming-of-the-ovarian-reserve-in-livestock
#38
JOURNAL ARTICLE
Robert A Cushman, Vahid Akbarinejad, George A Perry, Clay A Lents
Mammalian females are born with a finite number of follicles in their ovaries that is referred to as the ovarian reserve. There is a large amount of variation between females in the number of antral follicles that they are born with, but this number is positively correlated to size of the ovarian reserve, has a strong repeatability within a female, and a moderate heritability. Although the heritability is moderate, numerous external factors including health, nutrition, ambient temperature, and litter size influence the size and function of the ovarian reserve throughout life...
March 19, 2024: Animal Reproduction Science
https://read.qxmd.com/read/38531201/cirp-increases-foxp3-regulatory-t-cells-and-inhibits-development-of-th17-cells-by-enhancing-tlr4-il-2-signaling-in-the-late-phase-of-sepsis
#39
JOURNAL ARTICLE
Zongsheng Wu, Xu Liu, Wei Huang, Jing Chen, Songli Li, Jie Chao, Jianfeng Xie, Ling Liu, Yi Yang, Xiaojing Wu, Haibo Qiu
BACKGROUND: T helper (Th) cell imbalances have been associated with the pathophysiology of sepsis, including the Th1/Th2 and Th17/T regulatory cells (Treg) paradigms. Cold-inducible RNA-binding protein (CIRP), a novel damage-associated molecular pattern (DAMP) was reported that could induce T cell activation, and skew CD4+ T cells towards a Th1 profile. However, the effect and underlying mechanisms of CIRP on Th17/Treg differentiation in sepsis still remains unknown. METHODS: A prospective exploratory study including patients with sepsis was conducted...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38530938/discovery-of-cbpd-409-as-a-highly-potent-selective-and-orally-efficacious-cbp-p300-protac-degrader-for-the-treatment-of-advanced-prostate-cancer
#40
JOURNAL ARTICLE
Zhixiang Chen, Mi Wang, Dimin Wu, Lijie Zhao, Hoda Metwally, Wei Jiang, Yu Wang, Longchuan Bai, Donna McEachern, Jie Luo, Meilin Wang, Qiuxia Li, Aleksas Matvekas, Bo Wen, Duxin Sun, Arul M Chinnaiyan, Shaomeng Wang
CBP/p300 are critical transcriptional coactivators of the androgen receptor (AR) and are promising cancer therapeutic targets. Herein, we report the discovery of highly potent, selective, and orally bioavailable CBP/p300 degraders using the PROTAC technology with CBPD-409 being the most promising compound. CBPD-409 induces robust CBP/p300 degradation with DC50 0.2-0.4 nM and displays strong antiproliferative effects with IC50 1.2-2.0 nM in the VCaP, LNCaP, and 22Rv1 AR+ prostate cancer cell lines. It has a favorable pharmacokinetic profile and achieves 50% of oral bioavailability in mice...
March 26, 2024: Journal of Medicinal Chemistry
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