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Jing Ye, Guifeng Fu, Xiaohui Yan, Jingyi Liu, Xiaoyong Wang, Liang Cheng, Fan Zhang, Phillip Zhe Sun, Gang Liu
In vivo assessment of vascular permeability and therapeutic response provides novel insights into photothermal therapy (PTT) that is currently under clinical investigation. We have developed noninvasive imaging strategies to improve the monitoring of nanoparticle-mediated PTT responses for personalized nanomedicine. Briefly, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and photoacoustic imaging (PAI) were applied to study the enhanced permeability and retention (EPR) effect in tumor models of different microvascular permeabilities (i...
March 21, 2018: Nanoscale
Bian Jang, Madhappan Santha Moorthy, Panchanathan Manivasagan, Li Xu, Kyeongeun Song, Kang Dae Lee, Minseok Kwak, Junghwan Oh, Jun-O Jin
In advanced cancer therapy, the combinational therapeutic effect of photothermal therapy (PTT) using near-infrared (NIR) light-responsive nanoparticles (NPs) and anti-cancer drug delivery-mediated chemotherapy has been widely applied. In the present study, using a facile, low-cost, and solution-based method, we developed and synthesized fucoidan, a natural polymer isolated from seaweed that has demonstrated anti-cancer effect, and coated NPs with it as an ideal candidate in chemo-photothermal therapy against cancer cells...
February 27, 2018: Oncotarget
Hayrullah Yazar, Fatma Özdemir, Elif Köse
BACKGROUND: This study investigated the effects of cooled and standard centrifuges on the results of coagulation tests to examine the effects of centrifugation temperature. METHODS: Equal-volume blood samples from each patient were collected at the same time intervals and subjected to standard (25°C) and cooled centrifugation (2-4°C). Subsequently, the prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer values were determined in runs with the same lot numbers in the same coagulation device using the Dia-PT R (PT and INR), Dia-PTT-liquid (aPTT), Dia-FIB (fibrinogen), and Dia-D-dimer kits, respectively...
March 16, 2018: Acta Haematologica
Menglong Liu, Danfeng He, Tao Yang, Wei Liu, Li Mao, Yang Zhu, Jun Wu, Gaoxing Luo, Jun Deng
BACKGROUND: Silver and photothermal therapy (PTT) have been widely used for eradicating the drug-resistant bacteria. However, the risks of excess of silver for humans and the low efficiency of PTT still limit their in vivo therapeutic application. Integration of two distinctive bactericides into one entity is a promising platform to improve the efficiency of antimicrobial agents. RESULTS: In this study, a chemo-photothermal therapeutic platform based on polydopamine (PDA)-coated gold nanorods (GNRs) was developed...
March 16, 2018: Journal of Nanobiotechnology
Radosław Mrówczyński, Artur Jędrzak, Kosma Szutkowski, Bartosz F Grześkowiak, Emerson Coy, Roksana Markiewicz, Teofil Jesionowski, Stefan Jurga
Polydopamine (PDA)-coated magnetic nanoparticles functionalized with mono-6-thio-β-cyclodextrin (SH-βCD) were obtained and characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), Nuclear and Magnetic Resonance Imaging (NMR and MRI), and doxorubicin (DOXO)-loading experiments. The liver cancer cellular internalization of DOXO-loaded nanoparticles was investigated by confocal imaging microscopy. Synthesized nanomaterials bearing a chemotherapeutic drug and a layer of polydopamine capable of absorbing near-infrared light show high performance in the combined chemo- and photothermal therapy (CT-PTT) of liver cancer due to the synergistic effect of both modalities as demonstrated in vitro...
March 16, 2018: Nanomaterials
Barbara Bassi, Giacomo Dacarro, Pietro Galinetto, Enrico Giulotto, Nicoletta Marchesi, Piersandro Pallavicini, Alessia Pascale, Stefano Perversi, Angelo Taglietti
The last decade came across an increasing demand of theranostic biocompatible nanodevices, possessing the double ability of diagnosis and therapy. In this work, we report the design, synthesis and step-by-step characterization of rationally coated gold nanostars (GNS) for SERS imaging and photothermal therapy (PTT) of HeLa cancer cells. The nanodevice was realized synthesizing GNS with a seed-growth approach, coating them with a controlled mixture of thiols composed of a Raman reporter and a polyethylenglicol with a terminal amino group, and then reacting these amino groups with Folic Acid (FA), in order to impart selectivity towards cancer cells which overexpress folate receptors on their membranes...
March 16, 2018: Nanotechnology
Zhipeng Zhou, Yunkun Dang, Mian Zhou, Haiyan Yuan, Yi Liu
Codon usage biases are found in all genomes and influence protein expression levels. The codon usage effect on protein expression was thought to be mainly due to its impact on translation. Here we show that transcription termination is an important driving force for codon usage bias in eukaryotes. Using Neurospora crassa as a model organism, we demonstrated that introduction of rare codons results in premature transcription termination (PTT) within open reading frames and the abolishment of full-length mRNA...
March 16, 2018: ELife
Arezoo Mohammadi Gazestani, Samideh Khoei, Sepideh Khoee, Soraya Emamgholizadeh Minaei, Manijeh Motevalian
Magnetite nanographene oxide has exhibited great potential in drug delivery and photothermal therapy (PTT) for cancer treatment. Here we developed 5-fluorouracil-loaded poly (lactic-co-glycolic acid)-coated magnetite nanographene oxide (NGO-SPION-PLGA-5-Fu) to simplify combined PTT and chemotherapy in one complex. The nanocarrier was synthesized using a modified O1 /W1 /O2 /W2 multiple emulsion solvent evaporation method and was characterized for size, zeta potential, drug loading, in vitro and in vivo release...
March 15, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Yan Zhan, Yingliang Liu, Hongru Zu, Yanxian Guo, Shuangshuang Wu, Haiyao Yang, Zhiming Liu, Bingfu Lei, Jianle Zhuang, Xuejie Zhang, Di Huang, Chaofan Hu
Different from their bulk counterparts, plasmonic molybdenum oxide nanomaterials display superior optical and electronic properties, but unfortunately, phase-controlled synthesis of molybdenum oxide nanomaterials with multifunctional performances still remains a challenge. To actualize this, a surfactant-free solvothermal strategy was proposed to fabricate molybdenum oxide nanomaterials with a tunable phase. Encouragingly, the as-prepared molybdenum dioxide nanoparticles (MoO2 NPs) exhibit intense near-infrared (NIR) absorption attributed to the localized surface plasmon resonance (LSPR) effect, which results in their application as a surface enhanced Raman scattering (SERS) substrate to detect trace amounts of molecular species including Rhodamine 6G (R6G), crystal violet (CV), IR-780 iodide (IR780) and methylene blue (MB)...
March 15, 2018: Nanoscale
Jutaek Nam, Sejin Son, Lukasz J Ochyl, Rui Kuai, Anna Schwendeman, James J Moon
Photothermal therapy (PTT) is a promising cancer treatment modality, but PTT generally requires direct access to the source of light irradiation, thus precluding its utility against disseminated, metastatic tumors. Here, we demonstrate that PTT combined with chemotherapy can trigger potent anti-tumor immunity against disseminated tumors. Specifically, we have developed polydopamine-coated spiky gold nanoparticles as a new photothermal agent with extensive photothermal stability and efficiency. Strikingly, a single round of PTT combined with a sub-therapeutic dose of doxorubicin can elicit robust anti-tumor immune responses and eliminate local as well as untreated, distant tumors in >85% of animals bearing CT26 colon carcinoma...
March 14, 2018: Nature Communications
Tulio Diniz-Fernandes, Alexandre Leme Godoy-Santos, Maria Cristina Santo, Pedro Pontin, Caio Augusto Alves Pereira, Yuri Justi Jardim, Ana Paula Pereira Velosa, Nicola Maffulli, Walcy Rosolia Teodoro, Vera Luiza Capelozzi
Posterior tibial tendinopathy (PTT) can lead to acquired flatfoot in adults. Many patients develop PTT without any identifiable risk factors. Molecular changes in extracellular matrix (ECM) and matrix metalloproteinase (MMP) polymorphism may influence the risk of developing PTT. We aim to investigate the association between matrix metalloproteinase-1 (MMP-1) and (MMP-8) gene polymorphisms with changes in collagen I, III and V in PTT. A case-control study with 22 patients and 5 controls was performed. The MMP-1 (2G/2G) and MMP-8 (T/T) genotypes were determined by PCR-restriction fragment length polymorphism...
March 13, 2018: Histology and Histopathology
Xu Wang, Yinchu Ma, Xing Sheng, Yucai Wang, Hangxun Xu
Extensive efforts have been devoted to synthesizing photothermal agents (PTAs) that are active in the first near-infrared (NIR) region (650~950 nm). However, PTAs for photothermal therapy (PTT) in the second NIR window (1000~1350 nm) are still rare. Here, we show that two-dimensional ultrathin polypyrrole (PPy) nanosheets prepared via a novel space-confined synthesis method could exhibit unique broadband absorption with a large extinction coefficient of 27.8 L g-1 cm-1 at 1064 nm and can be used as an efficient PTA in the second NIR window...
March 12, 2018: Nano Letters
Hyo Sung Jung, Peter Verwilst, Amit Sharma, Jinwoo Shin, Jonathan L Sessler, Jong Seung Kim
Over the last decade, organic photothermal therapy (PTT) agents have attracted increasing attention as a potential complement for, or alternative to, classical drugs and sensitizers involving inorganic nanomaterials. In this tutorial review, we provide a structured description of the main classes of organic photothermal agents and their characteristics. Representative agents that have been studied in the context of photothermal therapy since 2000 are summarized and recent advances in using PTT agents to address various cancers indications are highlighted...
March 12, 2018: Chemical Society Reviews
Xu Zhen, Chen Xie, Kanyi Pu
Nanoparticles for photothermal therapy: Real-time temperature monitoring is critical to reduce the nonspecific damage during photothermal therapy (PTT); however, PTT agents that can emit temperature-related signals are rare and limited to few inorganic nanoparticles. We herein synthesize a semiconducting polymer nanococktail (SPNCT ) that can not only convert photo-energy to heat but also emit temperature-correlated luminescence after cessation of light excitation. Such an afterglow luminescence of the SPNCT detects tumors more sensitively than fluorescence as a result of the elimination of tissue autofluorescence, while its temperature-dependent nature allows tumor temperature to be optically monitored under near-infrared (NIR) laser irradiation...
March 12, 2018: Angewandte Chemie
Yu Cheng, Xiaoxiao Tan, Jinping Wang, Yidan Wang, Yilin Song, Qing You, Qi Sun, Li Liu, Siyu Wang, Fengping Tan, Jiao Li, Nan Li
Recently, ultrasmall gadolinium oxide (Gd2 O3 ) nanoparticles with high longitudinal relaxation rate have received enormous attention. However, it can't be concentrated in tumor site through intravenous administration due to its ultrasmall size. In this project, we coated ultrasmall Gd2 O3 nanoparticles with a near-infrared (NIR) light-absorbing polymer polypyrrole (PPy), modifying with hyaluronic acid (HA) and loaded aluminum phthalocyanine (AlPc), the Gd2 O3 @PPy/AlPc-HA nanoparticles could be used for fluorescence (FL)/magnetic resonance (MR)/photoacoustic (PA) imaging guided as well as remotely controlled PTT/PDT combined anti-tumor therapy...
March 8, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Jing Xu, Ning Ding, Xilong Zhang, Nana Wang, Bing Sun, Rong Zhang, Xiaochen Xie, Zongren Wan, Yanli Gu, Shan Zhang, Yongqing Hong, Mao Huang, Zili Meng
PURPOSE: Obstructive sleep apnea syndrome (OSAS) can induce dramatic blood pressure (BP) fluctuations during sleep and it can be associated with hypertension. We investigated the properties and associated influential factors of BP fluctuation in severe OSAS with and without hypertension. METHODS: Two hundred one severe OSAS subjects were divided into hypertensive and normotensive groups. BP was continuously monitored via measurement of pulse transmit time (PTT)...
March 9, 2018: Sleep & Breathing, Schlaf & Atmung
Mark Golberg, Joaquin Ruiz-Rivas, Sagi Polani, Yevgeny Beiderman, Zeev Zalevsky
Blood pressure (BP) is usually measured either invasively, by an intra-arterial catheter, or noninvasively, by a cuff-based sphygmomanometer. While the invasive method is continuous and more accurate, it has the risk of infection and generally is not comfortable for the patient. On the other hand, the cuff-based measurement is safer but less reliable and infrequent. Therefore, a reliable continuous noninvasive BP measurement is highly desirable. In this work, we propose a remote optical system, based on temporal analysis of secondary reflected speckle patterns, for computing a subject's pulse transit time (PTT)...
March 1, 2018: Applied Optics
Chenyang Xing, Shiyou Chen, Meng Qiu, Xin Liang, Quan Liu, Qingshuang Zou, Zhongjun Li, Zhongjian Xie, Dou Wang, Biqin Dong, Liping Liu, Dianyuan Fan, Han Zhang
Black phosphorus (BP) has recently emerged as an intriguing photothermal agent in photothermal therapy (PTT) against cancer by virtue of its high photothermal efficiency, biocompatibility, and biodegradability. However, naked BP is intrinsically characterized by easy oxidation (or natural degradation) and sedimentation inside the tumor microenvironment, leading to a short-term therapeutic and inhomogeneous photothermal effect. Development of BP-based nanocomposites for PTT against cancer therefore remains challenging...
March 6, 2018: Advanced Healthcare Materials
Yuan-Chung Tsai, Priya Vijayaraghavan, Wen-Hsuan Chiang, Hsin-Hung Chen, Te-I Liu, Ming-Yin Shen, Ayumu Omoto, Masao Kamimura, Kohei Soga, Hsin-Cheng Chiu
Therapeutic efficacy of glioblastoma multiforme (GBM) is often severely limited by poor penetration of therapeutics through blood-brain barrier (BBB) into brain tissues and lack of tumor targeting. In this regard, a functionalized upconversion nanoparticle (UCNP)-based delivery system which can target brain tumor and convert deep tissue-penetrating near-infrared (NIR) light into visible light for precise phototherapies on brain tumor was developed in this work. Methods : The UCNP-based phototherapy delivery system was acquired by assembly of oleic acid-coated UCNPs with angiopep-2/cholesterol-conjugated poly(ethylene glycol) and the hydrophobic photosensitizers...
2018: Theranostics
Chun-Yen Lin, Ming-Jium Shieh
Recently, nanoparticles (NPs) have been widely investigated for delivery of anticancer drugs. Here, a dual control drug-release modality was developed that uses naturally occurring protein apoferritin loaded with doxorubicin (DOX) and ADS-780 near infrared (NIR) fluorescent dye-decorated NPs (ADNIR NPs). ADNIR NPs act as a grenade to detonate the targeted tumor site following laser irradiation (photothermal therapy, PTT) and explode into cluster warheads (apoferritin-loaded DOX nanocages, AF-DOX NCs) that further destroy the tumor cells (chemotherapy)...
March 5, 2018: Bioconjugate Chemistry
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