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https://www.readbyqxmd.com/read/29336463/protein-corona-in-drug-delivery-for-multimodal-cancer-therapy-in-vivo
#1
Eugenia Li Ling Yeo, Patricia Soo Ping Thong, Khee Chee Soo, James Chen Yong Kah
The protein corona is inevitably formed on nanoparticles (NPs) when they are introduced in vivo and has been associated with a reduction in targeting yield, immune recognition and rapid blood clearance, leading to poor tumor accumulation. We have recently shown that it is possible to exploit the protein corona for drug delivery by exploiting it for loading and triggering the release of a photosensitizer Chlorin e6 (Ce6) for simultaneous photodynamic (PDT) and photothermal therapy (PTT) in vitro. Here, we extended our previous in vitro studies to evaluate its effectiveness in vivo...
January 16, 2018: Nanoscale
https://www.readbyqxmd.com/read/29334363/macrophage-membrane-coated-iron-oxide-nanoparticles-for-enhanced-photothermal-tumor-therapy
#2
Qian-Fang Meng, Lang Rao, Minghui Zan, Ming Chen, Guang-Tao Yu, Xiaoyun Wei, Zhuhao Wu, Yue Sun, Shi Shang Guo, Xing-Zhong Zhao, Fu-Bing Wang, Wei Liu
Nanotechnology possesses the potential to revolutionize the diagnosis and treatment of tumors. The ideal nanoparticles used for in vivo cancer therapy should own long blood circulation and active cancer targeting. Additionally, they should be innoxious and invisible to the immune system. Here, we developed a biomimetic nanoplatform with the above properties for cancer therapy. Macrophage membranes were reconstructed into vesicles and then coated onto magnetic iron oxide nanoparticles (Fe3O4 NPs). Inherited from the Fe3O4 core and the macrophage membrane shell, the resulting Fe3O4@MM NPs exhibited good biocompatibility, immune evasion, cancer targeting, and light-to-heat conversion capabilities...
January 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29330486/new-generation-of-drug-delivery-systems-based-on-ginsenoside-rh2-lysine-and-arginine-treated-highly-porous-graphene-for-improving-anticancer-activity
#3
Hadi Zare-Zardini, Asghar Taheri-Kafrani, Ahmad Amiri, Abdol-Khalegh Bordbar
In this study, Rh2-treated graphene oxide (GO-Rh2), lysine-treated highly porous graphene (Gr-Lys), arginine-treated Gr (Gr-Arg), Rh2-treated Gr-Lys (Gr-Lys-Rh2) and Rh2-treated Gr-Arg (Gr-Arg-Rh2) were synthesized. MTT assay was used for evaluation of cytotoxicity of samples on ovarian cancer (OVCAR3), breast cancer (MDA-MB), Human melanoma (A375) and human mesenchymal stem cells (MSCs) cell lines. The percentage of apoptotic cells was determined by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29328888/posterior-cruciate-ligament-reconstruction-with-transtibial-or-tibial-inlay-techniques-a-meta-analysis-of-biomechanical-and-clinical-outcomes
#4
Dong-Yeong Lee, Dong-Hee Kim, Hyun-Jung Kim, Hyeong-Sik Ahn, Tae-Ho Lee, Sun-Chul Hwang
BACKGROUND: Transtibial (TT) or tibial inlay (TI) techniques are commonly used for posterior cruciate ligament reconstruction (PCLR). However, the optimum method for PCLR after PCL injury remains debatable. Hypothesis/Purpose: The hypothesis was that TT and TI techniques would not show significant differences for all outcome measures. The purpose was to determine the biomechanical and clinical outcomes of TT and TI surgical techniques for PCLR. STUDY DESIGN: Meta-analysis; Level of evidence, 3...
January 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29328618/highly-crystalline-multicolor-carbon-nanodots-for-dual-modal-imaging-guided-photothermal-therapy-of-glioma
#5
Min Qian, Yilin Du, Shanshan Wang, Chengyi Li, Huiling Jiang, Wei Shi, Jian Chen, Yi Wang, Ernst Wagner, Rongqin Huang
Imaging-guided site-specific photothermal therapy (PTT) of glioma and other tumors in central nervous system (CNS) presents a great challenge for the current nanomaterial design. Herein, an in-situ solid-state transformation method was developed for the preparation of multicolor highly crystalline carbon nanodots (HCCDs). The synthesis yields 6-8 nm sized HCCDs containing a highly crystalline carbon nanocore and a hydrophilic surface, which therefore simultaneously provide strong photoacoustic and photothermal performance as well as tunable fluorescence emission...
January 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29326993/turning-double-hydrophilic-into-amphiphilic-ir825-conjugated-polymeric-nanomicelles-for-near-infrared-fluorescence-imaging-guided-photothermal-cancer-therapy
#6
Guang-Yu Pan, Hao-Ran Jia, Ya-Xuan Zhu, Fu-Gen Wu
Developing biocompatible and photodegradable photothermal agents (PTAs) holds great promise for potential clinical applications in photothermal cancer therapy. Herein, a new PTA was innovatively constructed by conjugating the hydrophobic near-infrared (NIR) heptamethine cyanine molecule IR825-NH2 with a double hydrophilic block copolymer methoxypoly(ethylene glycol)5k-block-poly(l-aspartic acid sodium salt)10 (abbreviated as PEG-PLD) via amine-carboxyl reaction. The as-designed PEG-PLD(IR825) was amphiphilic and could self-assemble into polymeric nanomicelles in aqueous solutions...
January 12, 2018: Nanoscale
https://www.readbyqxmd.com/read/29326806/negative-impact-of-prolonged-antibiotics-or-persistent-diarrhea-on-vitamin-k1-levels-in-2-24-weeks-aged-egyptian-infants
#7
Mohsen S Elalfy, Fatma S E Ebeid, Iman A Elagouza, Fatma A Ibrahim, Noura B M Hassan, Beshoy A Botros
Background: To evaluate the hazard of prolonged antibiotic therapy and/or persistent diarrhea on vitamin K1 (VK1) level and bleeding profile in infants (2-24 weeks). Methods: A one-year case-control study, conducted at Ain Shams University, Egypt. 338 infants (2-24 weeks) were recruited and divided into 3 groups (1:1:3 ratios); group A (n=67) patients who received antibiotics for ≥10 days, group B (n=67) who had persistent diarrhea ≥ 14 days and group C (n=204) age- and gender- matched infants who had not either received antibiotics nor had diarrhea...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29324310/25-hydroxyl-protopanaxatriol-protects-against-h2o2-induced-h9c2-cardiomyocytes-injury-via-pi3k-akt-pathway-and-apoptotic-protein-down-regulation
#8
Zhihao Wang, Guangyue Su, Zhiguo Zhang, Han Dong, Yuehui Wang, Huiying Zhao, Yuqing Zhao, Qi Sun
Oxidative stress injury and apoptosis are the main mechanisms of myocardial ischemia-reperfusion injury (MI/RI). Compounds with anti-oxidant properties can treat MI/RI. Therefore, identification of natural antioxidants such as herbs or botanical drugs is an ideal strategy to develop safe and effective anti-MI/RI drugs. Cardioprotective effects of Ginseng are well documented and are attributable to its anti-oxidant, anti-inflammatory, anti-tumorigenic, anti-arrhythmic, anti-ischemic properties. Ginseng monomer 20®-dammarane -3 beta,6 alpha,12 beta,20,25-pentol(25-hydroxyl-Protopanaxatriol,25-OH-PPT), a novel compound, which belongs to panaxatriol category, is extracted from the leaves and stem of ginseng...
January 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29320972/rituximab-use-in-pediatric-lupus-anticoagulant-hypoprothrombinemia-syndrome-report-of-three-cases-and-review-of-the-literature
#9
K Cetin Gedik, S Siddique, C L Aguiar
Lupus anticoagulant hypoprothrombinemia syndrome (LA-HPS) is a rare condition that may predispose both to thrombosis and bleeding due to positive lupus anticoagulant (LA) and factor II (FII) deficiency. It can be seen in association with infections or systemic lupus erythematosus (SLE) and may require glucocorticoids (GCs) and/or immunosuppressive medications. Pediatric LA-HPS cases in the literature and three cases that received only rituximab (RTX) for LA-HPS (in addition to GCs) at two institutions between January 2010 and June 2017 were analyzed descriptively...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29319536/new-photoplethysmogram-indicators-for-improving-cuffless-and-continuous-blood-pressure-estimation-accuracy
#10
Wan-Hua Lin, Hui Wang, Oluwarotimi Williams Samuel, Gengxing Liu, Zhen Huang, Guanglin Li
Objective: The accuracy of cuffless and continuous blood pressure (BP) estimation has been improved, but it is still unsatisfactory for clinical uses. This study was designed to further increase BP estimation accuracy. Approach: In this study, a number of new indicators were extracted from photoplethysmogram (PPG) recordings and linear regression method was used to construct BP estimation models based on the PPG indicators and pulse transit time (PTT). The performance of the BP estimation models was evaluated by the PPG recordings from 22 subjects when they performed mental arithmetic stress and Valsalva's manoeuvre tasks that could induce BP fluctuations...
December 28, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/29317418/home-polygraphic-recording-with-telemedicine-monitoring-for-diagnosis-and-treatment-of-sleep-apnoea-in-stroke-hopes-study-study-protocol-for-a-single-blind-randomised-controlled-trial
#11
Stefan Thomas Kotzian, Angela Schwarzinger, Sandra Haider, Bernd Saletu, Josef Spatt, Michael Timothy Saletu
INTRODUCTION: Meta-analyses report that more than 50% of patients who had a stroke suffer from moderate to severe sleep apnoea (SA), with adherence rates to positive airway pressure (PAP) therapy of only 30%. The primary objective of this study is to determine whether PAP adherence in patients who had a stroke with obstructive sleep apnoea (OSA) can be improved by a PAP training strategy during inhospital rehabilitation combined with a telemedicine monitoring system after discharge. Further objectives are (1) to compare the validity of a non-attended level-III polygraphy with that of a level-II polysomnography (PSG) in the diagnosis of SA, (2) to compare the validity of an apnoea-hypopnoea index (AHI) yielded by the PAP device with that obtained during PSG, (3) to determine changes in nocturnal systolic blood pressure (BP) due to PAP therapy with the pulse transit time (PTT) method and (4) to assess the impact of telemonitored PAP therapy on neurorehabilitation outcome parameters...
January 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29316453/degradable-rhenium-trioxide-nanocubes-with-high-localized-surface-plasmon-resonance-absorbance-like-gold-for-photothermal-theranostics
#12
Wenlong Zhang, Guoying Deng, Bo Li, Xinxin Zhao, Tao Ji, Guosheng Song, Zhiyin Xiao, Qing Cao, Jingbo Xiao, Xiaojuan Huang, Guoqiang Guan, Rujia Zou, Xinwu Lu, Junqing Hu
The applications of inorganic theranostic agents in clinical trials are generally limited to their innate non-biodegradability and potential long-term biotoxicity. To address this problem, herein via a straightforward and tailored space-confined on-substrate route, we obtained rhenium trioxide (ReO3) nanocubes (NCs) that display a good biocompatibility and biosafety. Importantly, their aqueous dispersion has high localized surface plasmon resonance (LSPR) absorbance in near-infrared (NIR) region different from previous report, which possibly associates with the charge transfer and structural distortion in hydrogen rhenium bronze (HxReO3), as well as ReO3's cubic shape...
December 27, 2017: Biomaterials
https://www.readbyqxmd.com/read/29316452/renal-clearable-quaternary-chalcogenide-nanocrystal-for-photoacoustic-magnetic-resonance-imaging-guided-tumor-photothermal-therapy
#13
Longfei Tan, Jing Wan, Weisheng Guo, Caizhang Ou, Tianlong Liu, Changhui Fu, Qiang Zhang, Xiangling Ren, Xing-Jie Liang, Jun Ren, Laifeng Li, Xianwei Meng
Ultrasmall Cu2ZnSnS4 (CZTS) nanocrystals with high near infrared (NIR) photothermal conversion abilities and peroxidase-mimic properties are synthesized and functionalized with bovine serum albumin (BSA) for rapid clearance multifunctional theranostic platform. Due to the presence of Cu (I) of CZTS@BSA, H2O2 could be decomposed to produce highly reactive oxygen species (ROS), catalyzed by intrinsic peroxidase like activity of CZTS. The CZTS@BSA possesses high NIR absorption and excellent photoacoustic (PA) imaging abilities...
January 2, 2018: Biomaterials
https://www.readbyqxmd.com/read/29313334/design-of-phase-changeable-and-injectable-alginate-hydrogel-for-imaging-guided-tumor-hyperthermia-and-chemotherapy
#14
Jiulong Zhao, Jialing Li, Chunping Zhu, Fei Hu, Hongyu Wu, Xiaohua Man, Zhaoshen Li, Changqing Ye, Duowu Zou, Shige Wang
The objective of the present study was to construct an alginate (AG) phase-changeable and injectable hydrogel for imaging-guided tumor hyperthermia and chemotherapy. Based on the binding between the α-L-guluronic blocks of AG and calcium ions, the AG/MoS2/Bi2S3-PEG (MBP)/doxorubicin (DOX) solution formed a cross-linked hydrogel to simultaneously encapsulate MBP nanosheets and DOX within the hydrogel matrix. The in situ-formed hydrogel can act as a reservoir to control the release of entrapped drug molecules, and the doped MBP nanosheets and DOX can realize computed tomography/photoacoustic dual-modal imaging-guided in vivo tumor PTT and chemotherapy, respectively...
January 9, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29303196/biodegradable-moox-nanoparticles-with-efficient-near-infrared-photothermal-and-photodynamic-synergetic-cancer-therapy-at-the-second-biological-window
#15
Wenyan Yin, Tao Bao, Xiao Zhang, Qin Gao, Jie Yu, Xinghua Dong, Liang Yan, Zhanjun Gu, Yuliang Zhao
Near-infrared (NIR) laser induced phototherapy has been considered as a noninvasive option for cancer therapy. Herein, we report plasmonic PEGylated molybdenum oxide nanoparticles (PEG-MoOx NPs) that were synthesized by using a facile hydrothermal method. The PEG-MoOx NPs exhibit broad absorption at the NIR biological window and remarkable photothermal conversion ability in the first (808 nm) and the second (1064 nm) windows. Moreover, the biocompatible PEG-MoOx NPs exhibit effective cellular uptake and could be eliminated gradually from the liver and spleen in mice...
January 5, 2018: Nanoscale
https://www.readbyqxmd.com/read/29297814/coagulation-assessment-underutilized-diagnostic-tools-in-zoo-and-aquatic-animal-medicine
#16
Trevor J Gerlach, Ashley Barratclough, Bobbi Conner
Veterinarians specializing in nondomestic species are faced with unique challenges regarding research and diagnostic capabilities given the wild and frequently dangerous nature of their patients. Standard diagnostic techniques used in small or large animal practice are not always possible due to anatomical constraints, size, tractability, or the inherent risk of anesthesia in highly valued, rare species. Diagnostic modalities that utilize simple, relatively noninvasive techniques show promise in evaluating nondomestic species and elucidating the pathophysiology behind poorly characterized disease processes in both wild and captive populations...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29290817/f%C3%A3-rster-resonance-energy-transfer-based-dual-modal-theranostic-nanoprobe-for-in-situ-visualization-of-cancer-photothermal-therapy
#17
Dehong Hu, Zonghai Sheng, Mingting Zhu, Xiaobing Wang, Fei Yan, Chengbo Liu, Liang Song, Ming Qian, Xin Liu, Hairong Zheng
The visualization of the treatment process in situ could facilitate to accurately monitor cancer photothermal therapy (PTT), and dramatically decrease the risk of thermal damage to normal cells and tissues, which represents a major challenge for cancer precision therapy. Herein, we prepare theranostic nanoprobes (NPs) for Förster resonance energy transfer (FRET)-based dual-modal imaging-guided cancer PTT, and clear visualization of the therapeutic process. The FRET-based theranostic NPs exhibit high FRET efficiency (88...
2018: Theranostics
https://www.readbyqxmd.com/read/29288576/gold-nanorod-photosensitizer-conjugates-with-glutathione-sensitive-linkages-for-synergistic-cancer-photodynamic-photothermal-therapy
#18
Jongseon Choi, Sangeun Lee, Jeong-Sook Park, So Yeon Kim
Recently, photodynamic therapy (PDT) has been intensively investigated as a useful modality for the treatment of various cancers. In addition, near infrared (NIR) photothermal therapy (PTT) using gold nanocarriers has attracted particular interest as a hyperthermia strategy. In this study, gold nanorod (AuNR)-photosensitizer conjugates with glutathione-sensitive linkages were designed for PDT and PTT. Several kinds of AuNRs with different aspect ratios were synthesized and modified with FA-conjugated block copolymers (FA-PEG-P(Asp)-DHLA) and Chlorine6 (Ce6) as a photosensitizer...
December 30, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29285274/lipopolysaccharide-coated-cus-nanoparticles-promoted-anti-cancer-and-anti-metastatic-effect-by-immuno-photothermal-therapy
#19
Bian Jang, Li Xu, Madhappan S Moorthy, Wei Zhang, Ling Zeng, Mingyeong Kang, Minseok Kwak, Junghwan Oh, Jun-O Jin
To meet the ultimate goal of cancer therapy, which is treating not only the primary tumor but also preventing metastatic cancer, the concept of combining immunotherapy with photothermal therapy (PTT) is gaining great interest. Here, we studied the new material, lipopolysaccharide (LPS) coated copper sulfide nanoparticles (LPS-CuS), for the immuno-photothermal therapy. We evaluated the effect of LPS-CuS for induction of apoptosis of CT26 cells and activation of dendritic cells. Moreover, the LPS-CuS and laser irradiation was examined anti-metastasis effect by liver metastasis model mouse in vivo...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29283336/photothermal-therapy-employing-gold-nanoparticle-loaded-macrophages-as-delivery-vehicles-comparing-the-efficiency-of-nanoshells-versus-nanorods
#20
Catherine Christie, Steen J Madsen, Qian Peng, Henry Hirschberg
Macrophages (Ma) loaded with gold based nanoparticles, which convert near infrared light to heat, have been studied as targeted transport vectors for photothermal therapy (PTT) of tumors. The purpose of the experiments reported here was to compare the efficacy of gold-silica nanoshells (AuNS) and gold nanorods (AuNR) in macrophage mediated PTT. PTT efficacy was evaluated in hybrid glioma spheroids consisting of human glioma cells and either AuNS or AuNR loaded Ma, designated MaNS and MaNR respectivly. Spheroids were irradiated for 10 min...
2017: Journal of Environmental Pathology, Toxicology and Oncology
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