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https://www.readbyqxmd.com/read/29775377/rate-and-state-friction-relation-for-nanoscale-contacts-thermally-activated-prandtl-tomlinson-model-with-chemical-aging
#1
Kaiwen Tian, David L Goldsby, Robert W Carpick
Rate and state friction (RSF) laws are widely used empirical relationships that describe macroscale to microscale frictional behavior. They entail a linear combination of the direct effect (the increase of friction with sliding velocity due to the reduced influence of thermal excitations) and the evolution effect (the change in friction with changes in contact "state," such as the real contact area or the degree of interfacial chemical bonds). Recent atomic force microscope (AFM) experiments and simulations found that nanoscale single-asperity amorphous silica-silica contacts exhibit logarithmic aging (increasing friction with time) over several decades of contact time, due to the formation of interfacial chemical bonds...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29774947/passive-engineering-mechanism-enhancement-of-a-flexor-digitorum-longus-tendon-transfer-procedure
#2
Connor M Pihl, Christina J Stender, Ravi Balasubramanian, Kylie M Edinger, Bruce J Sangeorzan, William R Ledoux
Standard treatments of adult acquired flatfoot deformity (AAFD) fail to correct associated dysfunction of the posterior tibial tendon (PTT). This study aimed to determine if a novel passive engineering mechanism (PEM) enhanced flexor digitorum longus (FDL) tendon transfer procedure would better restore physiologic PTT function to improve AAFD gait parameters compared to standard treatment. We evaluated the kinetic, pedobarographic, and kinematic effects of a pulley-based PEM-enhancement system utilizing a cadaveric flatfoot model and robotic gait simulator...
May 18, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29774760/safety-of-nonsteroidal-anti-inflammatory-drugs-in-copperhead-snakebite-patients
#3
Hoang X Pham, Michael E Mullins
INTRODUCTION: Current management guidelines for pit viper envenomations recommend against the use of nonsteroidal anti-inflammatory drugs (NSAIDs) for pain control due to concern for platelet dysfunction and resulting coagulopathy. However, prior research suggests that copperhead snakes generally do not cause coagulopathy and they are responsible for most of the venomous snakebites in the USA. Thus, we compared the occurrences of clinically apparent bleeding and most abnormal laboratory values of coagulation between copperhead envenomation patients who received NSAIDs and those who did not...
May 18, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29774663/dual-responsive-carbon-dot-for-ph-redox-triggered-fluorescence-imaging-with-controllable-photothermal-ablation-therapy-of-cancer
#4
Cheong A Choi, Jung Eun Lee, Zihnil Adha Islamy Mazrad, Young Kwang Kim, Insik In, Ji Hoon Jeong, Sung Young Park
We described fluorescence resonance energy transfer for pH/redox-activatable fluorescent carbon dot (FNP) to realize "off-on" switched imaging-guided controllable photothermal therapy (PTT). The FNP is a carbonized self-crosslinked polymer that allows IR825 loading (FNP[IR825]) via hydrophobic interactions in cancer therapy. The capability for fluorescence bioimaging was achieved via the internalization of FNP(IR825) into tumor cells, wherein glutathione (GSH) disulfide bonds were reduced and benzoic imine were cleaved under acidic conditions...
May 18, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29756230/the-relationship-between-pulmonary-artery-wedge-pressure-and-pulmonary-blood-volume-derived-from-contrast-echocardiography-a-proof-of-concept-study
#5
Ken Monahan, Daniel Lenihan, Evan L Brittain, Linda Saliba, Robert N Piana, Leslie L Robison, Melissa M Hudson, Gregory T Armstrong
BACKGROUND: Pulmonary transit time (PTT) obtained from contrast echocardiography is a marker of global cardiopulmonary function. Pulmonary blood volume (PBV), derived from PTT, may be a noninvasive surrogate for left-sided filling pressures, such as pulmonary artery wedge pressure (PAWP). We sought to assess the relationship between PBV obtained from contrast echocardiography and PAWP. METHODS: Participants were adult survivors of childhood cancer that had contrast echocardiography performed nearly simultaneously with right-heart catheterization...
May 14, 2018: Echocardiography
https://www.readbyqxmd.com/read/29753302/contribution-of-hepatic-retinaldehyde-dehydrogenase-induction-to-impairment-of-glucose-metabolism-by-high-fat-diet-feeding-in-c57bl-6j-mice
#6
Jiong Xu, Mian Zhang, Xiangping Zhang, Hanyu Yang, Binbin Sun, Zhongjian Wang, Yaqian Zhou, Shuting Wang, Xiaodong Liu, Li Liu
Obesity and insulin resistance are associated with overexpression of retinaldehyde dehydrogenase 1 (RALDH1). We aimed to investigate the roles of hepatic RALDH1 induction in glucose metabolism impairment using mice fed with high-fat diet (HFD). Mice were fed with HFD for 8 weeks and treated with RALDH inhibitor citral for another 4 weeks. Oral glucose tolerance test (OGTT), pyruvate tolerance test (PTT) and insulin tolerance test (ITT) were operated. Expressions of Phosphoenolpyruvate carboxykinase 1 (PCK1), glucokinase (GCK) and RALDH1 were measured...
May 12, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29747042/synthesis-of-carbon-dots-from-hypocrella-bambusae-for-bimodel-fluorescence-photoacoustic-imaging-guided-synergistic-photodynamic-photothermal-therapy-of-cancer
#7
Qingyan Jia, Xiuli Zheng, Jiechao Ge, Weimin Liu, Haohui Ren, Shiqing Chen, Yongmei Wen, Hongyan Zhang, Jiasheng Wu, Pengfei Wang
As phototheranostic agents, carbon dots (CDs), have recently drawn considerable attention due to their excellent physicochemical properties. However, the complex synthetic route and high-cost of CDs greatly limit their practical application. To address this issue, given their nearly infinite supply from nature, Hypocrella bambusae is used as the precursor for the preparation of CDs in this study. The obtained Hypocrella bambusae CDs (HBCDs) possess good water solubility, broad absorption (350-800 nm), red-light emission (maximum peak at 610 nm), and low biotoxicity...
May 4, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29745496/-pulse-transit-time-detection-based-on-waveform-time-domain-feature-and-dynamic-difference-threshold
#8
Zengding Liu, Ji Chen, Minfang Tang
Aiming at the defects that the traditional pulse transit time (PTT) detection methods are sensitive to changes in photoplethysmography (PPG) signal and require heavy computation, we proposed a new algorithm to detect PTT based on waveform time domain feature and dynamic difference threshold. We calculated the PTT by using dynamic difference threshold method to detect the R-waves of electrocardiogram (ECG), shortening the main peak detection range in PPG signal according to the characteristics of the waveform time domain, and using R wave to detect the main peak of PPG signal...
June 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29743489/magnetic-mesoporous-calcium-sillicate-chitosan-porous-scaffolds-for-enhanced-bone-regeneration-and-photothermal-chemotherapy-of-osteosarcoma
#9
Fan Yang, Jiawei Lu, Qinfei Ke, Xiaoyuan Peng, Yaping Guo, Xuetao Xie
The development of multifunctional biomaterials to repair bone defects after neoplasm removal and inhibit tumor recurrence remained huge clinical challenges. Here, we demonstrate a kind of innovative and multifunctional magnetic mesoporous calcium sillicate/chitosan (MCSC) porous scaffolds, made of M-type ferrite particles (SrFe12 O19 ), mesoporous calcium silicate (CaSiO3 ) and chitosan (CS), which exert robust anti-tumor and bone regeneration properties. The mesopores in the CaSiO3 microspheres contributed to the drug delivery property, and the SrFe12 O19 particles improved photothermal therapy (PTT) conversion efficacy...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29737836/intelligent-mno2-cu2-xs-for-multimode-imaging-diagnostic-and-advanced-single-laser-irradiated-photothermal-photodynamic-therapy
#10
Yu Cao, Xiangdan Meng, Dongdong Wang, Kai Zhang, Wenhao Dai, HaiFeng Dong, Xueji Zhang
Lately, photothermal therapy (PTT) and photodynamic therapy (PDT) dual-modal therapy has attracted much attention in cancer therapy as a synergistic therapeutic model. However, the integration of PDT and PTT in single nanoagent for cancer therapy is still a challenging task. Herein, an intelligent MnO2/Cu2-xS-siRNA nanoagent simultaneously overcoming inherent limitations of PDT and PTT with remarkable PTT/PDT therapeutic efficiency enabling multimode accurate tumor imaging diagnostic is designed. We first develop a general method to decorate Cu2-xS on the surface of MnO2 nanosheet (MnO2/Cu2-xS), then, it was loaded with heat shock protein (HSP) 70 siRNA to obtain MnO2/Cu2-xS-siRNA...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29733952/ph-sensitive-prodrug-conjugated-polydopamine-for-nir-triggered-synergistic-chemo-photothermal-therapy
#11
Huaihong Zhanga, Yu Sun, Rong Hung, Hui Cang, Zhaosheng Cai, Baiwang Sun
Combination of chemotherapy with photothermal therapy (PTT) demonstrate highly desirable for efficient medical treatment of tumor. At present works, camptothecin (CPT)-containing polymeric prodrug (PCPT) were fabricated by polymerization of a pH-sensitive camptothecin (CPT) prodrug monomer and MPC using reversible addition-fragmentation transfer (RAFT) strategy. The pH-sensitive polymeric prodrug was tethered onto surface of polydopamine (PDA) nanoparticles by amidation chemistry for combination of chemotherapy with photothermal therapy...
May 4, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29727164/all-in-one-theranostic-nanoagent-with-enhanced-reactive-oxygen-species-generation-and-modulating-tumor-microenvironment-ability-for-effective-tumor-eradication
#12
Yang Liu, Wenyao Zhen, Longhai Jin, Songtao Zhang, Guoying Sun, Tianqi Zhang, Xia Xu, Shuyan Song, Yinghui Wang, Jianhua Liu, Hongjie Zhang
Despite regulation of the reactive oxygen species (ROS) level is an intelligent strategy for cancer therapy, the therapeutic effects of ROS-mediated therapy (including photodynamic therapy (PDT) and chemodynamic therapy (CDT)) are limited by oxygen reliance, inherent flaws of traditional photosensitizers and strict reaction conditions of effective Fenton reaction. Herein, we reported biocompatible copper ferrite nanospheres (CFNs) with enhanced ROS production under irradiation with 650 nm laser through direct electron transfer and photo-enhanced Fenton reaction and high photothermal conversion efficiency upon exposure to 808 nm laser, exhibiting a considerable improved synergistic treatment effect...
May 4, 2018: ACS Nano
https://www.readbyqxmd.com/read/29725764/a-preliminary-videofluoroscopic-investigation-of-swallowing-physiology-and-function-in-individuals-with-oculopharyngeal-muscular-dystrophy-opmd
#13
Ashley A Waito, Catriona M Steele, Melanie Peladeau-Pigeon, Angela Genge, Zohar Argov
Dysphagia is one of the primary symptoms experienced by individuals with Oculopharyngeal Muscular Dystrophy (OPMD). However, we lack understanding of the discrete changes in swallowing physiology that are seen in OPMD, and the resulting relationship to impairments of swallowing safety and efficiency. This study sought to describe the pathophysiology of dysphagia in a small sample of patients with OPMD using a videofluoroscopy examination (VFSS) involving 3 × 5 mL boluses of thin liquid barium (22% w/v)...
May 3, 2018: Dysphagia
https://www.readbyqxmd.com/read/29722264/anti-egfr-peptide-conjugated-triangular-gold-nanoplates-for-computed-tomography-photoacoustic-imaging-guided-photothermal-therapy-of-non-small-cell-lung-cancer
#14
Ying Zhao, Wenfei Liu, Ying Tian, ZhenLu Yang, Xiaofen Wang, Yunlei Zhang, Yuxia Tang, Shuang Zhao, Chunyan Wang, Ying Liu, Jing Sun, Zhaogang Teng, Shouju Wang, Guangming Lu
Non-small cell lung cancer (NSCLC) is difficult to cure since the high recurrence rate and the side effects of current treatments. It is urgent to develop a new treatment that is safer and more effective than current treatments against NSCLC. Herein, we constructed anti-EGFR peptide conjugated PEGylated triangular gold nanoplates (TGN-PEG-P75) as a targeting photothermal therapy (PTT) agent to treat NSCLC under the guidance of computed tomography (CT) and photoacoustic imaging (PAI). The surface of TGNs is successfully conjugated with a novel peptide P75 that has the specific affinity with epidermal growth factor receptor (EGFR)...
May 3, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29721075/combining-photothermal-therapy-and-immunotherapy-against-melanoma-by-polydopamine-coated-al-2-o-3-nanoparticles
#15
Wenfei Chen, Ming Qin, Xiaoyan Chen, Qin Wang, Zhirong Zhang, Xun Sun
Photothermal therapy (PTT) can be an effective antitumor therapy, but it may not completely eliminate tumor cells, leading to the risk of recurrence or metastasis. Here we describe nanocarriers that allow combination therapy involving PTT and immunotherapy. Nanocarriers are prepared by coating Al2 O3 nanoparticles with non-toxic, biodegradable polydopamine, which shows high photothermal efficiency. A near-infrared laser irradiation can kill the majority of tumor tissues, resulting in the release of tumor-associated antigens...
2018: Theranostics
https://www.readbyqxmd.com/read/29720997/transposable-element-genomic-fissuring-in-pyrenophora-teres-is-associated-with-genome-expansion-and-dynamics-of-host-pathogen-genetic-interactions
#16
Robert A Syme, Anke Martin, Nathan A Wyatt, Julie A Lawrence, Mariano J Muria-Gonzalez, Timothy L Friesen, Simon R Ellwood
Pyrenophora teres , P. teres f. teres (PTT) and P. teres f. maculata (PTM) cause significant diseases in barley, but little is known about the large-scale genomic differences that may distinguish the two forms. Comprehensive genome assemblies were constructed from long DNA reads, optical and genetic maps. As repeat masking in fungal genomes influences the final gene annotations, an accurate and reproducible pipeline was developed to ensure comparability between isolates. The genomes of the two forms are highly collinear, each composed of 12 chromosomes...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29717822/soft-and-moldable-mg-doped-liquid-metal-for-conformable-skin-tumor-photothermal-therapy
#17
Xuelin Wang, Wenhao Yao, Rui Guo, Xiaohu Yang, Jianbo Tang, Jie Zhang, Weiping Gao, Victoria Timchenko, Jing Liu
As a class of emerging multifunctional soft materials, gallium-based liquid metal (LM) amalgams, metal/nonmetal particles dispersed in an LM environment, suggest a combination of intriguing properties. In this article, Mg particles in gallium-indium alloy for making new conceptual biomedical materials, which can adapt to any irregular skin surface, are introduced, and superior photothermal effect with a 61.5% photothermal conversion (PTC) increase with respect to that of the LM is realized. The formation of a new intermetallic phase Mg2 Ga5 and adjustable surface roughness, which guarantees a rapid temperature increase when illuminated by laser, are found to be responsible for the photothermal effect enhancement...
May 2, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29713600/spectrophotometric-analysis-of-thrombolytic-activity-sata-assay
#18
Masumeh Zamanlu, Morteza Eskandani, Reza Mohammadian, Nazila Entekhabi, Mohammad Rafi, Mehdi Farhoudi
Introduction: Measurement of thrombolytic activity is crucial for research and development of novel thrombolytics. It is a key factor in the assessment of the effectiveness of conventionally used thrombolytic therapies in the clinic. Previous methods used for the assessment of thrombolytic activity are often associated with some drawbacks such as being costly, time-consuming, complex with low accuracy. Here, we introduce a simple, economic, relatively accurate and fast method of spectrophotometric analysis of thrombolytic activity (SATA) assay, standardized by tissue plasminogen activator (tPA), which can quantitatively measure in vitro thrombolytic activity...
2018: BioImpacts: BI
https://www.readbyqxmd.com/read/29710744/changes-in-the-bilateral-pulse-transit-time-difference-with-a-moving-arm
#19
Xinge Jiang, Shoushui Wei, Dingchang Zheng, Peng Huang, Chengyu Liu
BACKGROUND: Changes of pulse transit time (PTT) induced by arm position were studied for unilateral arm. However, consistency of the PTT changes was not validated for both arm sides. OBJECTIVE: We aimed to quantify the PTT changes between horizontal and non-horizontal positions from right arm and left arm in order to explore the consistency of both arms. METHODS: Twenty-four normal subjects aged between 21 and 50 (14 male and 10 female) years were enrolled...
April 20, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29700991/a-new-treatment-modality-for-rheumatoid-arthritis-combined-photothermal-and-photodynamic-therapy-using-cu-7-2-s-4-nanoparticles
#20
Yao Lu, Lihua Li, Zefeng Lin, Liping Wang, Lijun Lin, Mei Li, Yu Zhang, Qingshui Yin, Qi Li, Hong Xia
Rheumatoid arthritis (RA) is a worldwide inflammatory disease that seriously threatens human health and needs more effective treatment approaches. Near infrared (NIR) light can efficiently penetrate inflamed joints affected by RA, so phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), may provide new opportunities. In this work, the unique Cu7.2 S4 nanoparticles (NPs) are prepared for RA treatment enlightened by the fact that copper (Cu)-based nanomaterials can simultaneously serve as PTT agents and photosensitizers (for PDT)...
April 26, 2018: Advanced Healthcare Materials
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