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https://www.readbyqxmd.com/read/29161627/nanoscaled-red-blood-cells-facilitate-breast-cancer-treatment-by-combining-photothermal-photodynamic-therapy-and-chemotherapy
#1
Guoyun Wan, Bowei Chen, Ling Li, Dan Wang, Shurui Shi, Tao Zhang, Yue Wang, Lianyun Zhang, Yinsong Wang
Red blood cells (RBCs)-based vesicles have been widely used for drug delivery due to their unique advantages. Intact RBCs contain a large amount of oxyhemoglobin (oxyHb), which can assist with photodynamic therapy (PDT). Indocyanine green (ICG), a photosensitizer both for photothermal therapy (PTT) and PDT, shows potent anticancer efficacy when combined with chemotherapeutic drug doxorubicin (DOX). In this study, we prepared nanoscaled RBCs (RAs) containing oxyHb and gas-generating agent ammonium bicarbonate (ABC) for co-loading and controlled release of ICG and DOX, thus hoping to achieve synergistic effects of PTT/PDT and chemotherapy against breast cancer...
November 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/29158839/characterization-of-cardiac-dynamics-in-an-acute-myocardial-infarction-model-by-four-dimensional-optoacoustic-and-magnetic-resonance-imaging
#2
Hsiao-Chun Amy Lin, Xosé Luís Déan-Ben, Ivana Ivankovic, Melanie A Kimm, Katja Kosanke, Helena Haas, Reinhard Meier, Fabian Lohöfer, Moritz Wildgruber, Daniel Razansky
Extraction of murine cardiac functional parameters on a beat-by-beat basis is limited with the existing imaging modalities due to insufficient three-dimensional temporal resolution. Faster volumetric imaging methods enabling in vivo characterization of functional parameters are poised to advance cardiovascular research and provide a better understanding of the mechanisms underlying cardiac diseases. We present a new approach based on analyzing contrast-enhanced optoacoustic (OA) images acquired at high volumetric frame rate without using cardiac gating or other approaches for motion correction...
2017: Theranostics
https://www.readbyqxmd.com/read/29158836/a-laser-activated-biocompatible-theranostic-nanoagent-for-targeted-multimodal-imaging-and-photothermal-therapy
#3
Liming Deng, Xiaojun Cai, Danli Sheng, Yang Yang, Eric M Strohm, Zhigang Wang, Haitao Ran, Dong Wang, Yuanyi Zheng, Pan Li, Tingting Shang, Yi Ling, Fengjuan Wang, Yang Sun
Multifunctional nanoparticles have been reported for cancer detection and treatment currently. However, the accurate diagnosis and efficient treatment for tumors are still not satisfied. Here we report on the development of targeted phase change multimodal polymeric nanoparticles for the imaging and treatment of HER2-positive breast cancer. METHODS: We evaluated the multimodal imaging capabilities of the prepared nanoparticles in vitro using agar-based phantoms. The targeting performance and cytotoxicity of the nanoparticles were examined in cell culture using SKBR3 (over-expressing HER2) and MDA-MB-231 (HER2 negative) cells...
2017: Theranostics
https://www.readbyqxmd.com/read/29156817/near-infrared-photothermal-therapy-using-anti-egfr-gold-nanorod-conjugates-for-triple-negative-breast-cancer
#4
Meihua Zhang, Hoe Suk Kim, Tiefeng Jin, Jisu Woo, Yin Ji Piao, Woo Kyung Moon
Current EGFR-targeted therapy for triple negative breast cancer (TNBC) has produced disappointing results. A rational therapeutic strategy to improve EGFR-targeted treatment for TNBC is therefore needed. In this study we evaluated the feasibility of treating TNBC using photoacoustic imaging (PAI)-guided near-infrared photothermal therapy (NIR-PTT) with anti-EGFR-conjugated gold nanorods (anti-EGFR-GN). NIR-PTT combined with anti-EGFR-GN exerted synergistic anti-proliferative and apoptotic actions through upregulation of HSP70 and cleaved caspase-3, downregulation of Ki-67 and EGFR, and inhibition of several intracellular signaling molecules (mTOR, AKT, ERK1/2 and FAK)...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155389/effect-of-the-polyelectrolyte-coating-on-the-photothermal-efficiency-of-gold-nanorods-and-the-photothermal-induced-cancer-cell-damage
#5
Rashmi Shrivastava, Alok Dube
Coating gold nanorods (GNRs) with polyelectrolytes is an effective approach to make them biocompatible for potential use in photothermal treatment (PTT) of cancer. The authors report the effect of coating of the GNRs with polystyrene sulphonate (PSS-GNRs) and PSS plus poly di-allyl di-methyl ammonium chloride (PDDAC-GNRs) on its photothermal conversion efficiency (PTE), cellular uptake and subsequently the photothermal induced cytotoxicity in human oral cancer cells (NT8e). Coating of GNRs with PSS led to decrease in PTE by ∼30% and further coating it with PDDAC led to its increase to similar level, with respect to as- prepared GNRs...
December 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29154833/photo-based-pdt-ptt-dual-model-killing-and-imaging-of-cancer-cells-using-phycocyanin-polypyrrole-nanoparticles
#6
Subramaniyan Bharathiraja, Panchanathan Manivasagan, Madhappan Santha Moorthy, Nhat Quang Bui, Bian Jang, Thi Tuong Vy Phan, Won-Kyo Jung, Young-Mok Kim, Kang Dae Lee, Junghwan Oh
Photodynamic therapy (PDT) and photothermal therapy (PTT) using nanoparticles have gained significant attention for its therapeutic effect for cancer treatment. In the present study, we fabricated polypyrrole nanoparticles by employing bovine serum albumin-phycocyanin complex and the formulated particles were stable in various physiological solutions like water, phosphate buffered saline and culture media. The formulated nanoparticles did not cause any noticeable toxicity to MDA-MB-231 and HEK-293 cells. The obtained nanoparticles effectively killed MDA-MB-231 cells in a dual way upon laser illumination, one is through phycocyanin propagated reactive oxygen species (PDT) upon laser illumination and in another way it eradicated the treated cells by converting optical energy into heat energy (PTT)...
November 14, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29154532/cus-based-theranostic-micelles-for-nir-controlled-combination-chemotherapy-and-photothermal-therapy-and-photoacoustic-imaging
#7
Guojun Chen, Ben Ma, Yuyuan Wang, Ruosen Xie, Chun Li, Kefeng Dou, Shaoqin Gong
Cancer remains a major threat to human health due to low therapeutic efficacies of currently available cancer treatment options. Nanotheranostics, capable of simultaneous therapy and diagnosis/monitoring of diseases, has attracted increasing amounts of attention, particularly for cancer treatment. In this study, CuS-based theranostic micelles capable of simultaneous combination chemotherapy and photothermal therapy (PTT), as well as photoacoustic imaging, were developed for targeted cancer therapy. The micelle was formed by a CuS nanoparticle (NP) functionalized by thermosensitive amphiphilic poly(acrylamide-acrylonitrile)-poly(ethylene glycol) block copolymers...
November 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29148623/dual-roles-of-protein-as-a-template-and-a-sulfur-provider-a-general-approach-to-metal-sulfides-for-efficient-photothermal-therapy-of-cancer
#8
Jianping Sheng, Liqiang Wang, Yajing Han, Wansong Chen, Hong Liu, Min Zhang, Liu Deng, You-Nian Liu
Fabrication of clinically translatable nanoparticles (NPs) as photothermal therapy (PTT) agents against cancer is becoming increasingly desirable, but still challenging, especially in facile and controllable synthesis of biocompatible NPs with high photothermal efficiency. A new strategy which uses protein as both a template and a sulfur provider is proposed for facile, cost-effective, and large-scale construction of biocompatible metal sulfide NPs with controlled structure and high photothermal efficiency...
November 17, 2017: Small
https://www.readbyqxmd.com/read/29138401/imaging-the-transient-heat-generation-of-individual-nanostructures-with-a-mechanoresponsive-polymer
#9
Xueqin Chen, Qing Xia, Yue Cao, Qianhao Min, Jianrong Zhang, Zixuan Chen, Hong-Yuan Chen, Jun-Jie Zhu
Measuring the localized transient heat generation is critical for developing applications of nanomaterials in areas of photothermal therapy (PTT), drug delivery, optomechanics and biological processes engineering. However, accurate thermometry with high spatiotemporal resolution is still a challenge. Here we develop a thermosensitive polymer-capped gold nanorod (AuNRs@pNIPAAm), which has temperature-dependent local surface plasmon resonance spectra due to the submolecular conformational change of pNIPAAm molecules...
November 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/29125688/a-metal-polyphenol-network-coated-nanotheranostic-system-for-metastatic-tumor-treatments
#10
Jin-Xuan Fan, Di-Wei Zheng, Wen-Wen Mei, Si Chen, Si-Yi Chen, Si-Xue Cheng, Xian-Zheng Zhang
As a characteristic trait of most tumor types, metastasis is the major cause of the death of patients. In this study, a photothermal agent based on gold nanorod is coated with metal (Gd(3+) )-organic (polyphenol) network to realize combination therapy for metastatic tumors. This nanotheranostic system significantly enhances antitumor therapeutic effects in vitro and in vivo with the combination of photothermal therapy (PTT) and chemotherapy, also can remarkably prevent the invasion and metastasis due to the presence of polyphenol...
November 10, 2017: Small
https://www.readbyqxmd.com/read/29125675/simultaneous-application-of-photothermal-therapy-and-anti-inflammatory-prodrug-using-pyrene-aspirin-loaded-gold-nanorod-graphitic-nanocapsules
#11
Qian Dong, Xuewei Wang, Xiaoxiao Hu, Langqiu Xiao, Liang Zhang, Lijuan Song, Minglu Xu, Yuxiu Zou, Long Chen, Zhuo Chen, Weihong Tan
Photothermal therapy (PTT) has been extensively developed as an effective approach against cancer. In some cases, however, PTT can trigger inflammatory responses, in turn simulating tumor regeneration and hindering subsequent therapy. We herein developed a therapeutic strategy able to deliver enhanced PTT and simultaneously inhibite PTT-induced inflammatory response. 1-Pyrene methanol was utilize to synthesize anti-inflammatory prodrug pyrene-aspirin (P-aspirin) with cleavable ester bond, and also facilitate loading the prodrug on gold nanorod (AuNR)-encapsulated graphitic nanocapsule (AuNR@G), a photothermal agent, through π-π interaction...
November 10, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29124966/marine-natural-pigments-as-potential-sources-for-therapeutic-applications
#12
Panchanathan Manivasagan, Subramaniyan Bharathiraja, Madhappan Santha Moorthy, Sudip Mondal, Hansu Seo, Kang Dae Lee, Junghwan Oh
In recent years, marine natural pigments have emerged as a powerful alternative in the various fields of food, cosmetic, and pharmaceutical industries because of their excellent biocompatibility, bioavailability, safety, and stability. Marine organisms are recognized as a rich source of natural pigments such as chlorophylls, carotenoids, and phycobiliproteins. Numerous studies have shown that marine natural pigments have considerable medicinal potential and promising applications in human health. In this review, we summarize the marine natural pigments as potential sources for therapeutic applications, including: antioxidant, anticancer, antiangiogenic, anti-obesity, anti-inflammatory activities, drug delivery, photothermal therapy (PTT), photodynamic therapy (PDT), photoacoustic imaging (PAI), and wound healing...
November 10, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/29123392/self-assembled-albumin-nanoparticles-for-combination-therapy-in-prostate-cancer
#13
Huibo Lian, Jinhui Wu, Yiqiao Hu, Hongqian Guo
Resistance to regular treatment strategies is a big challenge in the treatment of castration-resistant prostate cancer. Combination of photothermal and photodynamic therapy (PTT/PDT) with chemotherapy offers unique advantages over monotherapy alone. However, free drugs, such as photosensitizers and chemotherapeutic agents, lack tumor-targeted accumulation and can be easily eliminated from the body. Moreover, most of the PTT drugs are hydrophobic and their organic solvents have in vivo toxicity, thereby limiting their potential in clinical translation...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29120347/cuff-less-blood-pressure-measurement-from-dual-channel-photoplethysmographic-signals-via-peripheral-pulse-transit-time-with-singular-spectrum-analysis
#14
Yang Wang, Zhiwen Liu, Shaodong Ma
This paper proposes an unobtrusive blood pressure (BP) measurement system design with motion artifact (MA) compensation strategy as a potential surrogate to the traditional cuff-based sphygmomanometer for self-monitoring in less restricted environment. Approach: A dual-channel photoplethysmographic signal acquisition system is designed and implemented for the cuff-less BP measurement based on peripheral pulse transit time (PPTT) acquired from the forearm and wrist. Comprised of motion decision, singular spectrum analysis, PPTT calculation and BP measurement, a novel approach is proposed to realize BP measurement with suppressing MA interference...
November 9, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/29119157/fluorine-free-preparation-of-titanium-carbide-mxene-quantum-dots-with-high-near-infrared-photothermal-performances-for-cancer-therapy
#15
Xinghua Yu, Xingke Cai, Haodong Cui, Seung-Wuk Lee, Xue-Feng Yu, Bilu Liu
Titanium carbide MXene quantum dots (QDs) were synthesized using an effective fluorine-free method as a biocompatible and highly efficient nanoagent for photothermal therapy (PTT) applications. In contrast to the traditional, hazardous and time-consuming process of HF pretreatment, our fluorine-free method is safe and simple. More importantly, abundant Al oxoanions were found to be modified on the MXene QD surface by the fluorine-free method, which endowed the QDs with strong and broad absorption in the NIR region...
November 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/29109796/investigating-the-effect-of-chemical-structure-of-semiconducting-polymer-nanoparticle-on-photothermal-therapy-and-photoacoustic-imaging
#16
Dongdong Li, Guobing Zhang, Weiguo Xu, Junxia Wang, Yucai Wang, Longzhen Qiu, Jianxun Ding, Xianzhu Yang
The donor-acceptor semiconducting polymers (SPs) have robust absorbance in near-infrared (NIR) region, great photostability, high photothermal conversion efficiency, and good biocompatibility. Thus, the SPs exhibit great potentials for photothermal therapy (PTT) and photoacoustic imaging (PAI). However, poor understanding of the underlying mechanisms and the correlation between the SP polymer chemical structures and their performances of PTT and PAI have significantly hindered their biomedical application. Herein, a series of acceptor-π-acceptor type (A1-π-A2) type SPs were synthesized...
2017: Theranostics
https://www.readbyqxmd.com/read/29109786/-one-pot-fabrication-of-highly-versatile-and-biocompatible-poly-vinyl-alcohol-porphyrin-based-nanotheranostics
#17
Yan Luo, Hao Wu, Caihong Feng, Kai Xiao, Xixiao Yang, Qiangqiang Liu, Tzu-Yin Lin, Hongyong Zhang, Jeffrey H Walton, Yousif Ajena, Yide Hu, Kit S Lam, Yuanpei Li
Nanoparticle-based theranostic agents have emerged as a new paradigm in nanomedicine field for integration of multimodal imaging and therapeutic functions within a single platform. However, the clinical translation of these agents is severely limited by the complexity of fabrication, long-term toxicity of the materials, and unfavorable biodistributions. Here we report an extremely simple and robust approach to develop highly versatile and biocompatible theranostic poly(vinyl alcohol)-porphyrin nanoparticles (PPNs)...
2017: Theranostics
https://www.readbyqxmd.com/read/29104699/the-application-of-titanium-dioxide-zinc-oxide-fullerene-and-graphene-nanoparticles-in-photodynamic-therapy
#18
REVIEW
Zahraa Youssef, Régis Vanderesse, Ludovic Colombeau, Francis Baros, Thibault Roques-Carmes, Céline Frochot, Habibah Wahab, Joumana Toufaily, Tayssir Hamieh, Samir Acherar, Amirah Mohd Gazzali
Nanoparticles (NPs) have been shown to have good ability to improve the targeting and delivery of therapeutics. In the field of photodynamic therapy (PDT), this targeting advantage of NPs could help ensure drug delivery at specific sites. Among the commonly reported NPs for PDT applications, NPs from zinc oxide, titanium dioxide, and fullerene are commonly reported. In addition, graphene has also been reported to be used as NPs albeit being relatively new to this field. In this context, the present review is organized by these different NPs and contains numerous research works related to PDT applications...
2017: Cancer Nanotechnology
https://www.readbyqxmd.com/read/29097820/electrical-stimulation-of-hyoid-muscles-in-post-stroke-dysphagia
#19
Petr Konecny, Milan Elfmark
AIMS: The purpose of this study was to evaluate swallowing changes in post-stroke patients with dysphagia after four weeks of suprahyoid muscles electrical stimulation. METHODS: This was a prospective randomized study of early stage stroke patients with dysphagia. Electrical stimulation of suprahyoid muscles was given to a group of 54 patients (26 men, average age 70 years) for 20 minutes a day, 5 days a week. Standard orofacial rehabilitation without electrical stimulation was carried out on a control group of 54 patients (31 men, average age 69 years)...
November 2, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29094389/antiferromagnetic-pyrite-as-the-tumor-microenvironment-mediated-nanoplatform-for-self-enhanced-tumor-imaging-and-therapy
#20
Zhongmin Tang, Huilin Zhang, Yanyan Liu, Dalong Ni, Hua Zhang, Jiawen Zhang, Zhenwei Yao, Mingyuan He, Jianlin Shi, Wenbo Bu
Several decades of research have identified the specific tumor microenvironment (TME) to develop promising nanotheranostics, such as pH-sensitive imaging, acidity-sensitive starving therapy, and hydrogen peroxide-activated chemotherapy, etc. Herein, a novel TME-mediated nanoplatform employing antiferromagnetic pyrite nanocubes is presented, exploiting the intratumoral, overproduced peroxide for self-enhanced magnetic resonance imaging (MRI) and photothermal therapy (PTT)/chemodynamic therapy (CDT). Through the activation of excessive peroxide in the tumor microenvironment, pyrite can lead to in situ surface oxidation and generate hydroxyl radicals to kill tumor cells (i...
November 2, 2017: Advanced Materials
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