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https://www.readbyqxmd.com/read/28532415/hemodynamic-changes-caused-by-acupuncture-in-healthy-volunteers-a-prospective-single-arm-exploratory-clinical-study
#1
Tae-Hun Kim, Boncho Ku, Jang-Han Bae, Jae-Young Shin, Min-Ho Jun, Jung Won Kang, Junghwan Kim, Jun-Hwan Lee, Jaeuk U Kim
BACKGROUND: Radial pressure pulse wave (RPPW) examination has been a key diagnostic component of traditional Chinese medicine. The objective of this study was to investigate the changes in RPPW along with various hemodynamic variables after acupuncture stimulation and to examine the validity of pulse diagnosis as a modern diagnostic tool. METHODS: We conducted acupuncture stimulation at both ST36 acupuncture points in 25 healthy volunteers. We simultaneously assessed the RPPW by pulse tonometry; heart rate variability (HRV) by electrocardiogram; photoplethysmogram (PPG) signals, respiration rate, peripheral blood flow velocity and arterial depth by ultrasonography; and cardiac output by impedance cardiography, before, during and after a session of acupuncture stimulation...
May 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28531140/a-cuffless-blood-pressure-measurement-based-on-the-impedance-plethysmography-technique
#2
Shing-Hong Liu, Da-Chuan Cheng, Chun-Hung Su
In the last decade, cuffless blood pressure measurement technology has been widely studied because it could be applied to a wearable apparatus. Electrocardiography (ECG), photo-plethysmography (PPG), and phonocardiography are always used to detect the pulse transit time (PTT) because the changed tendencies of the PTT and blood pressure have a negative relationship. In this study, the PPG signal was replaced by the impedance plethysmography (IPG) signal and was used to detect the PTT. The placement and direction of the electrode array for the IPG measurement were discussed...
May 21, 2017: Sensors
https://www.readbyqxmd.com/read/28529642/tumor-triggered-drug-release-from-calcium-carbonate-encapsulated-gold-nanostars-for-near-infrared-photodynamic-photothermal-combination-antitumor-therapy
#3
Yanlei Liu, Xiao Zhi, Meng Yang, Jingpu Zhang, Lingnan Lin, Xin Zhao, Wenxiu Hou, Chunlei Zhang, Qian Zhang, Fei Pan, Gabriel Alfranca, Yuming Yang, Jesús M de la Fuente, Jian Ni, Daxiang Cui
Different stimulus including pH, light and temperature have been used for controlled drug release to prevent drug inactivation and minimize side-effects. Herein a novel nano-platform (GNS@CaCO3/ICG) consisting of calcium carbonate-encapsulated gold nanostars loaded with ICG was established to couple the photothermal properties of gold nanostars (GNSs) and the photodynamic properties of indocyanine green (ICG) in the photodynamic/photothermal combination therapy (PDT/PTT). In this study, the calcium carbonate worked not only a drug keeper to entrap ICG on the surface of GNSs in the form of a stable aggregate which was protected from blood clearance, but also as the a pH-responder to achieve highly effective tumor-triggered drug release locally...
2017: Theranostics
https://www.readbyqxmd.com/read/28529636/a-new-green-titania-with-enhanced-nir-absorption-for-mitochondria-targeted-cancer-therapy
#4
Juan Mou, Tianquan Lin, Fuqiang Huang, Jianlin Shi, Hangrong Chen
A new kind of green titania (G-TiO2-x ) with obvious green color was facilely synthesized from black titania (B-TiO2-x ) through subsequently strong ultrasonication. Comparatively, this stable G-TiO2-x shows much enhanced near infrared (NIR) absorption, especially around 920 nm, which can be ascribed to the obvious change of TiO2-x lattice order owing to the effect of ultrasonication. This feature enables G-TiO2-x to be stimulated with 980 nm laser in the combined photodynamic therapy (PDT) and photothermal therapy (PTT), which is greatly beneficial for improving tissue penetration depth...
2017: Theranostics
https://www.readbyqxmd.com/read/28527427/photothermal-therapy-using-folate-conjugated-gold-nanoparticles-enhances-the-effects-of-6mv-x-ray-on-mouth-epidermal-carcinoma-cells
#5
Ali Neshastehriz, Mousa Tabei, Shayan Maleki, Samira Eynali, Ali Shakeri-Zadeh
The aim of this study was to develop an optimized method for preparation of folate conjugated gold nanoparticles (F-AuNPs) and to investigate its cytotoxic effects and cell apoptosis in combination with photothermal therapy (PTT) and radiotherapy (RT) for the treatment of mouth epidermal carcinoma cells KB. For this purpose, cells were treated with synthesized F-AuNPs at different concentrations for 6h and then irradiated them with laser beam (532nm, 0.5W/cm(2), 15min). After photothermal therapy, the cells were exposed to 6MV X-ray with a single dose of 2Gy...
May 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28525715/ultra-small-magnetic-cufese2-ternary-nanocrystals-for-multimodal-imaging-guided-photothermal-therapy-of-cancer
#6
Xinxin Jiang, Shaohua Zhang, Feng Ren, Lei Chen, Jianfeng Zeng, Mo Zhu, Zhenxiang Cheng, Mingyuan Gao, Zhen Li
Nanoscale ternary chalcogenides have attracted intense research interest due to their wealth of tunable properties and diverse applications in energy, environmental and biomedical fields. In this article, ultra-small magnetic CuFeSe2 ternary nanocrystals (< 5.0 nm) were fabricated in the presence of thiol functionalized poly(methacrylic acid) (PTMP-PMAA) by an environmentally friendly aqueous method under ambient conditions. The small band gap and the existence of intermediate bands lead to a broad NIR absorbance in the range of 500 - 1100 nm, and high photothermal conversion efficiency (82%) of CuFeSe2 nanocrystals...
May 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28522841/near-infrared-heptamethine-cyanine-based-iron-oxide-nanoparticles-for-tumor-targeted-multimodal-imaging-and-photothermal-therapy
#7
Sejy Lee, Reju George Thomas, Myeong Ju Moon, Hyeong Ju Park, In-Kyu Park, Byeong-Il Lee, Yong Yeon Jeong
Near-infrared fluorescent (NIRF) imaging modality holds great promise for tumor detection and offers several advantages of bioimaging, such as high tissue penetration with less background scattering. The disadvantage of NIRF bioimaging is that it has very low spatial resolution. Thus, the combination of NIRF with magnetic resonance imaging (MRI) is a good option because MRI can provide anatomical information with a higher resolution. Heptamethine cyanine dye (MHI-148) has been reported to have tumor-targeting capability which was used here as the NIRF agent...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28522192/overcoming-photodynamic-resistance-and-tumor-targeting-dual-therapy-mediated-by-indocyanine-green-conjugated-gold-nanospheres
#8
Wei Li, Xiaomeng Guo, Fenfen Kong, Hanbo Zhang, Lihua Luo, Qingpo Li, Chunqi Zhu, Jie Yang, Yongzhong Du, Jian You
Photodynamic therapy (PDT) and photothermal therapy (PTT) have captured much attention due to the great potential to cure malignant tumor. Nevertheless, photodynamic resistance of cancer cells has limited the further efficacy of PDT. Unfortunately, the resistance mechanism and efforts to overcome the resistance still have been rarely reported so far. Here, we report a nanosystem with specific tumor targeting for combined PDT and PTT mediated by near-infrared (NIR) light, which was established by covalently conjugating indocyanine green (ICG) and TNYL peptide onto the surface of hollow gold nanospheres (HAuNS)...
May 15, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28508635/polydopamine-coated-manganese-carbonate-nanoparticles-for-amplified-magnetic-resonance-imaging-guided-photothermal-therapy
#9
Youxing Cheng, Shupeng Zhang, Ning Kang, Jianpan Huang, Xiaolin Lv, Kai Wen, Shefang Ye, Zhiwei Chen, Xi Zhou, Lei Ren
This study reports a multifunctional nanoparticle (NP) that can be used for amplified magnetic resonance image (MRI)-guided photothermal therapy (PTT) due to its surface coating with a polydopamine (PDA) shell. Importantly, by means of introducing the surface coating of PDA, large quantities of water can be trapped around the NPs allowing more efficient water exchange, leading to greatly improved MR contrast signals compared with those from NPs without the PDA coating. Further, a distinct photothermal effect can be obtained arising from the strong absorption of PDA in the near-infrared (NIR) region...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28507594/pain-threshold-reflects-psychological-traits-in-patients-with-chronic-pain-a-cross-sectional-study
#10
Fumie Kato, Tetsuya Abe, Kenji Kanbara, Ikumi Ban, Tadashi Kiba, Sadanobu Kawashima, Yukie Saka, Yasuyuki Mizuno, Mikihiko Fukunaga
BACKGROUND: Chronic pain enhances sensory sensitivity and induces the biased development of psychological traits such as depression and pain catastrophizing, leading to the formation of heterogeneous conditions. Fluctuations in the sensory-related thresholds of non-injured sites (with normal peripheral tissue) in patients with chronic pain are thought to be related to central sensitization. The objectives of this study were to analyze the association between pain tolerance thresholds (PTTs) in non-injured sites and the psychological traits of patients with chronic pain and to evaluate the usefulness of PTT measures in assessments of pathological conditions related to chronic pain...
2017: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/28501673/chemotherapeutic-drug-photothermal-agent-co-self-assembling-nanoparticles-for-near-infrared-fluorescence-and-photoacoustic-dual-modal-imaging-guided-chemo-photothermal-synergistic-therapy
#11
Yang Li, Guihua Liu, Jinyuan Ma, Jinyan Lin, Huirong Lin, Guanghao Su, Dengyue Chen, Shefang Ye, Xiaoyuan Chen, Xuan Zhu, Zhenqing Hou
Multimodal imaging-guided synergistic combination therapy has shown great potential for cancer treatment. However, the nanocarrier-based theranostic systems suffer from batch-to-batch variation, complexity of multicomponent, poor drug loading, and carrier-related toxicity issues. To address these issues, herein we developed a novel carrier-free theranostic system with nanoscale characteristics for near-infrared fluorescence (NIRF) and photoacoustic (PA) dual-modal imaging-guided synergistic chemo-photothermal therapy (PTT)...
May 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28499573/positive-thinking-training-intervention-for-caregivers-of-persons-with-autism-establishing-fidelity
#12
Abir K Bekhet
More than 3.5 million in the US are diagnosed with autism spectrum disorder (ASD) and caregivers experience stress that adversely affects their well-being. Positive thinking training (PTT) intervention can minimize that stress. However, before testing the effectiveness of PTT, its fidelity must be established. This pilot intervention trial examined fidelity of an online PTT intervention for ASD caregivers with a random assignment of 73 caregivers to either the online PTT intervention or to the control group...
June 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28493504/imaging-sonographic-findings-of-in-a-case-of-proliferating-trichilemmal-tumor-of-a-finger-a-case-report
#13
Ki Eon Kwon, Seon-Jeong Kim, Joo Hak Kim, Yoon Yang Jung, Noh Hyuck Park, Ji Yeon Park, Kyung A Kang, Soo Heui Baek
Proliferating trichilemmal tumor (PTT) is a rare tumor that originates from the outer root sheath of a hair follicle. About 90% of PTTs occur on the scalp. The sonographic findings of PTT in the subungual region have not been reported previously. In our case, sonography showed a heterogeneous mass containing echogenic foci with no detectable intratumoral vascularity. These echogenic foci probably represent keratin and cholesterol. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound, 2017.
May 11, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28492507/core-shell-magnetic-gold-nanoparticles-for-magnetic-field-enhanced-radio-photothermal-therapy-in-cervical-cancer
#14
Rui Hu, Minxue Zheng, Jinchang Wu, Cheng Li, Danqing Shen, Dian Yang, Li Li, Mingfeng Ge, Zhimin Chang, Wenfei Dong
The combination of radiotherapy (RT) and photothermal therapy (PTT) has been considered an attractive strategy in cervical cancer treatment. However, it remains a challenge to simultaneously enhance the radio-sensitivity of tumor tissue, develop tumor tissue-focused radiation therapies and combine dual therapeutic modalities. In this study, core-shell type magnetic gold (Fe₃O₄@Au) nanoparticles are exploited to achieve the synergistic efficacy of radio-photothermal therapy in cervical cancer. Fe₃O₄@Au nanoparticles (NPs) with uniform morphology exhibited superior surface plasmon resonance properties, excellent superparamagnetic properties, good biocompatibility and high photothermal conversion efficiency...
May 11, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28487048/relationship-between-grading-with-magnetic-resonance-imaging-and-radiographic-parameters-in-posterior-tibial-tendon-dysfunction
#15
Kazuya Ikoma, Yusuke Hara, Masamitsu Kido, Kan Imai, Masahiro Maki, Suzuyo Ohashi, Toshikazu Kubo
The objective of the present study was to elucidate the relationship between the state of the posterior tibial tendon (PTT) on magnetic resonance images and foot deformity. The cases included 34 feet in 27 patients with PTT deformity and the controls included 18 feet in 12 patients who had undergone magnetic resonance imaging for other foot diseases. The PTT was closely examined on the magnetic resonance images and classified using the Conti classification. The control feet with no injury to the PTT were classified as grade 0...
May 6, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28485579/marriage-of-albumin-gadolinium-complexes-and-mos2-nanoflakes-as-cancer-theranostics-for-dual-modality-magnetic-resonance-photoacoustic-imaging-and-photothermal-therapy
#16
Liang Chen, Xiaojun Zhou, Wei Nie, Wei Feng, Qianqian Zhang, Weizhong Wang, Yanzhong Zhang, Zhigang Chen, Peng Huang, Chuanglong He
The construction of safe and stable theranostics is beneficial to realize simultaneous cancer diagnosis and treatment. In this study, bovine serum albumin-gadolinium (BSA-Gd) complexes and MoS2 nanoflakes (MoS2-Gd-BSA) were successfully married as cancer theranostics for dual-modality magnetic resonance (MR)/photoacoustic (PA) imaging and photothermal therapy (PTT). BSA-Gd complexes were prepared by the biomineralization method and then conjugated with MoS2 nanoflakes via an amide bond. The as-prepared MoS2-Gd-BSA possessed a good photostability and photothermal effect...
May 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28484754/dual-modal-imaging-guided-highly-efficient-photothermal-therapy-using-heptamethine-cyanine-conjugated-hyaluronic-acid-micelles
#17
Sanpeng Li, Zhihong Sun, Guanjun Deng, Xiaoqing Meng, Wenjun Li, Dapeng Ni, Jiali Zhang, Ping Gong, Lintao Cai
Targeted phototherapy and multi-modal imaging can effectively improve the therapeutic efficacy and reduce the side effects of theranostics. Herein, we constructed novel biocompatible cyanine dye IR808-conjugated hyaluronic acid nanoparticles (HAIR NPs) for photothermal therapy (PTT) with near-infrared fluorescence (FL) and photoacoustic (PA) dual-modal imaging. The nanoparticles formed stable nanostructures under aqueous conditions with uniform size distribution. The HAIR NPs were rapidly taken up by the human lung cancer cells A549 via CD44 (the hyaluronic acid receptor on the surface of tumor cells) receptor-mediated endocytosis...
May 9, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28476550/disseminated-intravascular-coagulation-is-associated-with-the-neurologic-outcome-of-cardiac-arrest-survivors
#18
Dong Hun Lee, Byung Kook Lee, Kyung Woon Jeung, Yong Hun Jung, Sung Min Lee, Yong Soo Cho, Seong-Woo Yun, Yong Il Min
PURPOSE: We aimed to examine the serial changes in coagulofibrinolytic markers that occurred after the restoration of spontaneous circulation (ROSC) in cardiac arrest patients, who were treated with targeted temperature management (TTM). We also evaluated the association between the disseminated intravascular coagulation (DIC) score and clinical outcomes. METHODS: This was a single-centre, retrospective observational study that included cardiac arrest patients who were treated with TTM from May 2012 to December 2015...
May 1, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28464525/hollow-au-cu-nanocomposite-for-real-time-tracing-photothermal-antiangiogenic-therapy
#19
Xiaojuan Pang, Xiaoxiao Tan, Jinping Wang, Li Liu, Qing You, Qi Sun, Yidan Wang, Fengping Tan, Nan Li
High absorption in the near-infrared (NIR) region is essential for a photoabsorbing agents to realize efficient photothermal therapy (PTT) for cancer. Here, a novel hollow Au-Cu nanocomposite (HGCNs) is developed, which displays a significantly enhanced NIR surface plasmon resonance absorption and photothermal transduction efficiency. Besides, fluorescent polymer dots poly(9,9-dioctylfluorene-2,7-diyl-co-benzothiadiazole) (PFBT) and chemotherapeutic mammalian target of rapamycin (mTOR) inhibitor agent rapamycin (RAPA) are attached onto the HGCNs (RAPA/PFBT-HGCNs) for real-time NIR fluorescence tracing and combined PTT/antiangiogenesis therapy...
May 2, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28463207/a-novel-continuous-blood-pressure-estimation-approach-based-on-data-mining-techniques
#20
Fen Miao, Nan Fu, Yuan-Ting Zhang, Xiao-Rong Ding, Xi Hong, Qingyun He, Ye Li
Continuous blood pressure (BP) estimation using pulse transit time (PTT) is a promising method for unobtrusive BP measurement. However, the accuracy of this approach must be improved for it to be viable for a wide range of applications. This study proposes a novel continuous BP estimation approach that combines data mining techniques with a traditional mechanism-driven model. First, 14 features derived from simultaneous electrocardiogram and photoplethysmogram signals were extracted for beat-to-beat BP estimation...
April 28, 2017: IEEE Journal of Biomedical and Health Informatics
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