Zehua Zhang, Xiaohan Yan, Le Kang, Zhuyun Leng, Yingjie Ji, Shuangzhu Yang, Xiaojing Du, Kang Fang, Zeyu Wang, Zhaoxing Li, Mingchuang Sun, Ziying Zhao, Anqi Feng, Zhukai Chen, Shihan Zhang, Dong Wan, Tao Chen, Meidong Xu
Transient receptor potential melastatin 8 (TRPM8) is a cold sensory receptor in primary sensory neurons that regulates various neuronal functions. Substance P (SP) is a pro-inflammatory neuropeptide secreted by the neurons, and it aggravates colitis. However, the regulatory role of TRPM8 in SP release is still unclear. Our study aimed to investigate TRPM8's role in SP release from primary sensory neurons during colitis and clarify the effect of SP on colonic epithelium. We analyzed inflammatory bowel disease patients' data from the Gene Expression Omnibus dataset...
January 27, 2024: Cell Death & Disease