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https://www.readbyqxmd.com/read/29676695/huge-heterogeneity-in-survival-in-a-subset-of-adult-patients-with-resected-wild-type-isocitrate-dehydrogenase-status-who-grade-ii-astrocytomas
#1
Gaëtan Poulen, Catherine Gozé, Valérie Rigau, Hugues Duffau
OBJECTIVE World Health Organization grade II gliomas are infiltrating tumors that inexorably progress to a higher grade of malignancy. However, the time to malignant transformation is quite unpredictable at the individual patient level. A wild-type isocitrate dehydrogenase (IDH-wt) molecular profile has been reported as a poor prognostic factor, with more rapid progression and a shorter survival compared with IDH-mutant tumors. Here, the oncological outcomes of a series of adult patients with IDH-wt, diffuse, WHO grade II astrocytomas (AII) who underwent resection without early adjuvant therapy were investigated...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676166/the-need-for-and-implementation-of-image-guidance-in-radiation-therapy
#2
G S Ibbott
The introduction of image guidance in radiation therapy and its subsequent innovations have revolutionised the delivery of cancer treatment. Modern imaging systems can supplement and often replace the historical practice of relying on external landmarks and laser alignment systems. Rather than depending on markings on the patient's skin, image-guided radiation therapy (IGRT), using techniques such as computed tomography (CT), cone beam CT, MV on-board imaging (OBI), and kV OBI, allows the patient to be positioned based on the internal anatomy...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29674005/breast-cancer-cutaneous-metastases-mimicking-papilloma-cutis-lymphostatica-biopsy-to-avoid-pitfalls
#3
Giuseppe Giudice, Michelangelo Vestita, Fabio Robusto, Paolo Annoscia, Francesco Ciancio, Eleonora Nacchiero
INTRODUCTION: Secondary lymphedema is the most frequent long-term complication of axillary lymphadenectomy. It can result in complication as erysipelas, warts, Papilloma Cutis Lymphostatica (PCL), or angiosarcomas. Moreover, in women affected by breast cancer an accurate differential diagnosis among these conditions or complication related to radiation dermatitis or cutaneous metastasis is essential. PRESENTATION OF CASE: We report the case of a 60-year-old postmenopausal Caucasian woman affected by secondary lymphedema following complete mastectomy for breast cancer...
April 10, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29673878/down-regulation-of-mir-373-increases-the-radiosensitivity-of-lung-cancer-cells-by-targeting-timp2
#4
Yinghua Guo, Yingxiao Jiang, Maozhong Sang, Chunli Xu
BACKGROUND: Radiotherapy is a widely used effective treatment for lung cancer in clinic. MicroRNAs (miRNAs) have been proved to play an important role in radiation response. This study aimed to explore the regulatory role and mechanism of miR-373 in lung cancer cell radiosensitivity. METHODS: qRT-PCR was used to analyze the expression of miR-373 in lung cancer tissues and cell lines. MiR-373 expression was overexpressed or knocked down by transfection with miR-373 mimic or inhibitor...
April 16, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29673614/lacunar-stroke-cavernous-angioma-and-fusiform-aneurysm-due-to-irradiation-for-pilocytic-astrocytoma-a-case-report
#5
Maruyama Kunitaka, Takuya Akai, Naoki Akioka, Takahiro Tomita, Shoichi Nagai, Satoshi Kuroda
Radiotherapy is a useful modality for the treatment of brain tumors, but may induce brain degeneration, tumor formation, and vasculopathy in the irradiated field. We describe a rare case of a pediatric patient who presented multiple different types of vascular events consecutively in the irradiated field including lacunar stroke because of occlusion of perforating artery, intraventricular hemorrhage from cavernoma, and subarachnoid hemorrhage because of the rupture of fusiform aneurysm, 6 years after radiotherapy against pilocytic astrocytoma...
April 16, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29671690/application-of-a-novel-murine-ear-vein-model-to-evaluate-the-effects-of-a-vascular-radioprotectant-on-radiation-induced-vascular-permeability-and-leukocyte-adhesion
#6
Kathleen A Ashcraft, Kingshuk Roy Choudhury, Sam R Birer, Hansford C Hendargo, Pranalee Patel, Gary Eichenbaum, Mark W Dewhirst
Vascular injury after radiation exposure contributes to multiple types of tissue injury through a cascade of events. Some of the earliest consequences of radiation damage include increased vascular permeability and promotion of inflammation, which is partially manifested by increased leukocyte-endothelial (L/E) interactions. We describe herein a novel intravital imaging method to evaluate L/E interactions, as a function of shear stress, and vascular permeability at multiple time points after local irradiation to the ear...
April 19, 2018: Radiation Research
https://www.readbyqxmd.com/read/29670854/deep-inspiration-breath-hold-techniques-and-advantages-for-cardiac-sparing-during-breast-cancer-irradiation
#7
REVIEW
Carmen Bergom, Adam Currey, Nina Desai, An Tai, Jonathan B Strauss
Historically, heart dose from left-sided breast radiotherapy has been associated with a risk of cardiac injury. Data suggests that there is not a threshold for the deleterious effects from radiation on the heart. Over the past several years, advances in radiation delivery techniques have reduced cardiac morbidity due to treatment. Deep inspiration breath hold (DIBH) is a technique that takes advantage of a more favorable position of the heart during inspiration to minimize heart doses over a course of radiation therapy...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29667369/fully-automated-production-and-characterization-of-64cu-and-proof-of-principle-small-animal-pet-imaging-using-64cu-labelled-ca-xii-targeting-6a10-fab
#8
Luise Fiedler, Markus Kellner, Rosel Oos, Guido Böning, Sibylle Ziegler, Peter Bartenstein, Reinhard Zeidler, Franz Josef Gildehaus, Simon Lindner
64Cu is a cyclotron-produced radionuclide which offers, due to its characteristic decay scheme the possibility to combine PET investigations with radiotherapy. We evaluated the Alceo sys-tem from Comecer SpA to automatically produce 64Cu for radiolabelling purposes. We established a 64Cu production routine with high yields and radionuclide purity in combination with excellent operator radiation protection. The carbonic anhydrase XII targeting 6A10 antibody fab fragment was successfully radiolabelled with the produced 64Cu and proof of principle small animal PET experiments on mice bearing glioma xenografts were performed...
April 18, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29667046/radiotherapy-in-patients-with-cardiac-implantable-electronic-devices-clinical-and-dosimetric-aspects
#9
Giulia Riva, Ombretta Alessandro, Ruggero Spoto, Annamaria Ferrari, Cristina Garibaldi, Federica Cattani, Rosa Luraschi, Elena Rondi, Nicola Colombo, Fulvio Lorenzo Francesco Giovenzana, Carlo Maria Cipolla, Mikolaj Winnicki, Martina Persiani, Fabiana Castelluccia, Massimo Sarra Fiore, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
As a result of aging, the number of patients with cardiac implantable electronic device (CIED) requiring radiotherapy (RT) continues to rise. The aim of this work was to evaluate RT-related malfunctions of CIED in a cohort of patients who underwent RT in our clinic from June 2010 to December 2016. We retrospectively analyzed 93 RT treatments in 63 patients with CIEDs. Patients were treated with 3D conformal RT, intensity-modulated RT and stereotactic RT. We collected clinical characteristics of cancer, models of CIEDs, total RT dose to tumor and radiation energy...
April 17, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29666957/conditioned-medium-from-umbilical-cord-mesenchymal-stem-cells-improves-nasal-mucosa-damage-by-radiation
#10
Hong-Gang Duan, Fang Ji, Chun-Quan Zheng, Jing Li, Jing Wang
OBJECTIVES: To explore therapeutic effects of conditioned medium from human umbilical cord mesenchymal stem cells (hUC-MSCs) on nasal mucosa radiation damage both in vivo and in vitro. RESULTS: The mucus cilia clearance time (7 and 30 days), degree of mucosal edema (7, 30, 90 and 180 days), cilia coverage (180 days) of concentrated conditioned medium group improved compared with radiotherapy control group. The proliferation and migration abilities of irradiated and non-irradiated nasal epithelial cells significantly increased after culture in bronchial epithelial cell growth medium (BEGM) containing 10% conditioned medium of hUC-MSCs compared to cells cultured in BEGM alone...
April 17, 2018: Biotechnology Letters
https://www.readbyqxmd.com/read/29666802/advances-in-radiotherapy-for-esophageal-cancer
#11
REVIEW
Wei Deng, Steven H Lin
Esophageal cancer is a common type of malignancy worldwide and usually requires multidisciplinary care. Radiotherapy plays an important part in management of the disease. During the past few years, researchers have made much progress about radiotherapy for esophageal cancer, which was revealed in every aspect of clinical practice. Neoadjuvant chemoradiotherapy remains the standard treatment for locally advanced esophageal cancer, whereas neoadjuvant chemotherapy appears to show less toxicities and non-inferior prognosis...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666782/new-perspectives-on-diagnosis-and-therapy-of-malignant-pleural-mesothelioma
#12
REVIEW
Marika Rossini, Paola Rizzo, Ilaria Bononi, Anthony Clementz, Roberto Ferrari, Fernanda Martini, Mauro G Tognon
Malignant pleural mesothelioma (MPM) is a rare, but severe form of cancer, with an incidence that varies significantly within and among different countries around the world. It develops in about one to two persons per million of the general population, leading to thousands of deaths every year worldwide. To date, the MPM is mostly associated with occupational asbestos exposure. Asbestos represents the predominant etiological factor, with approximately 70% of cases of MPM with well-documented occupational exposure to asbestos, with the exposure time, on average greater than 40 years...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29665832/volumetric-and-dosimetric-comparison-of-organs-at-risk-between-the-prone-and-supine-positions-in-postoperative-radiotherapy-for-prostate-cancer
#13
Subaru Sawayanagi, Hideomi Yamashita, Mami Ogita, Tomoki Kiritoshi, Takahiro Nakamoto, Osamu Abe, Keiichi Nakagawa
BACKGROUND: The aim of this study was to evaluate the effects of patient positioning on the volume of organs at risk (OARs) in or near the planning target volume (PTV) and the dose distribution in adjuvant or salvage radiotherapy for prostate cancer after prostatectomy. METHODS: Seventeen patients who received intensity-modulated radiation therapy (66 Gy in 33 fractions) as adjuvant or salvage therapy after prostatectomy were evaluated. All patients underwent CT scans in both the prone (on a belly board) and supine positions...
April 17, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29665327/adjuvant-radiotherapy-and-chemotherapy-improve-survival-in-patients-with-pancreatic-adenocarcinoma-receiving-surgery-adjuvant-chemotherapy-alone-is-insufficient-in-the-era-of-intensity-modulation-radiation-therapy
#14
Mao-Chih Hsieh, Wei-Wen Chang, Hsin-Hsien Yu, Chang-Yun Lu, Chia-Lun Chang, Jyh-Ming Chow, Shee-Uan Chen, Yunfeng Cheng, Szu-Yuan Wu
In the era of intensity modulation radiation therapy (IMRT), no prospective randomized trial has evaluated the efficacy of adjuvant therapies such as adjuvant concurrent chemoradiotherapy (CCRT), adjuvant sequential chemotherapy and radiotherapy (CT-RT), and adjuvant CT alone in resectable pancreatic adenocarcinoma (PA). Through propensity score matching, we designed a nationwide, population-based, head-to-head cohort study to determine the effects of dissimilar adjuvant treatments on resectable PA. We minimized the confounding of various adjuvant treatment outcomes among the following resectable PA groups of patients from the Taiwan Cancer Registry database: group 1, adjuvant CCRT; group 2, adjuvant sequential CT-RT; and group 3, adjuvant CT alone...
April 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29664796/long-term-outcomes-with-ifosfamide-based-hypofractionated-preoperative-chemoradiotherapy-for-extremity-soft-tissue-sarcomas
#15
Joseph Daniel Pennington, Fritz C Eilber, Frederick R Eilber, Arun S Singh, Jarred P Reed, Bartosz Chmielowski, Jeffrey J Eckardt, Susan V Bukata, Nicholas M Bernthal, Noah Federman, Scott D Nelson, Sarah M Dry, Pin-Chieh Wang, Michael Luu, Michael T Selch, Michael L Steinberg, Anusha Kalbasi, Mitchell Kamrava
OBJECTIVES: The objective of this study was to analyze outcomes for patients with soft tissue sarcoma of the extremities using neoadjuvant ifosfamide-based chemotherapy and hypofractionated reduced dose radiotherapy, followed by limb-sparing surgery. MATERIALS AND METHODS: An Institutional Review Board (IRB)-approved retrospective review of patients treated at a single institution between 1990 and 2013 was performed. In total, 116 patients were identified who received neoadjuvant ifosfamide-based chemotherapy and 28 Gy in 8 fractions of preoperative radiation (equivalent dose in 2 Gray fractions, 31...
April 16, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29664324/the-work-programme-of-eurados-on-internal-and-external-dosimetry
#16
W Rühm, J F Bottollier-Depois, P Gilvin, R Harrison, Ž Knežević, M A Lopez, R Tanner, A Vargas, C Woda
Since the early 1980s, the European Radiation Dosimetry Group (EURADOS) has been maintaining a network of institutions interested in the dosimetry of ionising radiation. As of 2017, this network includes more than 70 institutions (research centres, dosimetry services, university institutes, etc.), and the EURADOS database lists more than 500 scientists who contribute to the EURADOS mission, which is to promote research and technical development in dosimetry and its implementation into practice, and to contribute to harmonisation of dosimetry in Europe and its conformance with international practices...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29664218/parotid-gland-radiation-dose-xerostomia-relationships-based-on-actual-delivered-dose-for-nasopharyngeal-carcinoma
#17
Jingjiao Lou, Pu Huang, Changsheng Ma, Yue Zheng, Jinhu Chen, Yueqiang Liang, Hongsheng Li, Yong Yin, Danhua Liu, Gang Yu, Dengwang Li
Xerostomia induced by radiotherapy is a common toxicity for head and neck carcinoma patients. In this study, the deformable image registration of planning computed tomography (CT) and weekly cone-beam CT (CBCT) was used to override the Hounsfield unit value of CBCT, and the modified CBCT was introduced to estimate the radiation dose delivered during the course of treatment. Herein, the beams from each patient's treatment plan were applied to the modified CBCT to construct the weekly delivered dose. Then, weekly doses were summed together to obtain the accumulated dose...
April 17, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29664052/value-of-adjuvant-radiotherapy-for-thymoma-with-myasthenia-gravis-after-extended-thymectomy
#18
Chang-Feng Lu, Lei Yu, Yun Jing, Yun-Feng Zhang, Ji Ke
Background: The co-existence of myasthenia gravis (MG) and thymoma makes the surgical treatment more complicated and adjuvant radiation more controversial. The aim of this study was to investigate adjuvant radiotherapy for thymoma with MG after extended thymectomy. Methods: A total of 181 patients with both MG and thymoma were recruited between 2003 and 2014 at Tongren Hospital, China. Among all the patients, 157 patients received radiation therapy after surgery (Group A); whereas the other 24 patients did not receive radiation therapy (Group B)...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29663624/a-cross-sectional-study-of-agreement-between-the-hospital-anxiety-and-depression-scale-patient-and-radiation-oncologist-reported-single-item-assessment-of-depression-and-anxiety
#19
Lisa Mackenzie, Mariko Carey, Eiji Suzuki, Michio Yoshimura, Masakazu Toi, Catherine D'Este, Rob Sanson-Fisher
OBJECTIVE: To describe, among radiation oncology patients: The proportion likely to be experiencing symptoms of depression and anxiety as identified by: a) the Hospital Anxiety and Depression Scale (HADS; standardised tool); b) Patient-reported single-items (ultra-short tool); and c) Radiation oncologist-reported single items (clinician judgement); Preferences for being offered psychological support; and Agreement between single-item measures and the HADS. METHODS: Adult cancer patients (n = 152; consent rate 58%) receiving radiotherapy completed a touchscreen tablet survey assessing symptoms of anxiety and depression (HADS and a single-item tool) and support preferences...
April 16, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29663431/a-novel-verification-method-using-a-plastic-scintillator-imagining-system-for-assessment-of-gantry-sag-in-radiotherapy
#20
Masato Tsuneda, Teiji Nishio, Akito Saito, Sodai Tanaka, Tatsuhiko Suzuki, Daisuke Kawahara, Keiichiro Matsushita, Aya Nishio, Shuichi Ozawa, Kumiko Karasawa, Yasushi Nagata
PURPOSE: High accuracy of the beam-irradiated position is required for high-precision radiation therapy such as stereotactic body radiation therapy (SBRT), volumetric modulated arc therapy (VMAT) and intensity modulated radiation therapy (IMRT). Users generally perform the verification of the mechanical and radiation isocenters using the star shot test and the Winston Lutz test that allow evaluation of the displacement at the isocenter. However, these methods are unable to evaluate directly and quantitatively the sagging angle that is caused by the weight of the gantry itself along the gantry rotation axis...
April 16, 2018: Medical Physics
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