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https://www.readbyqxmd.com/read/27922181/evaluation-of-gas-and-carbon-transport-in-a-methanogenic-bioelectrochemical-system-bes
#1
Christy M Dykstra, Spyros G Pavlostathis
Bioelectrochemical systems (BESs) may be used to upgrade anaerobic digester biogas by directly converting CO2 to CH4 .The objective of this study was to evaluate gas (N2 , CO2 , CH4 , and H2 ) and carbon transport within a methanogenic BES. Four BES configurations were evaluated: abiotic anode with abiotic cathode (AAn-ACa), bioanode with abiotic cathode (BAn-ACa), abiotic anode with biocathode (AAn-BCa), and bioanode with biocathode (BAn-BCa). Transport of N2 , a gas commonly used for flushing anoxic systems, out of the anode headspace ranged from 3...
December 6, 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27903199/the-2016-aans-presidential-address-leading-the-way
#2
H Hunt Batjer, Vin Shen Ban
This AANS presidential address focuses on enduring values of the neurosurgical profession that transcend the current political climate. The address was delivered by Dr. Batjer during a US presidential election year, but the authors have intentionally avoided discussing the current chaos of the American health care system in the knowledge that many pressing issues will change depending on the outcome of the 2016 elections. Instead, they have chosen to focus on clarifying what neurosurgeons, and the American Association of Neurological Surgeons, in particular, stand for; identifying important challenges to these fundamental principles and values; and proposing specific actions to address these challenges...
December 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27763560/renal-protective-effects-of-17%C3%AE-estradiol-on-mice-with-acute-aristolochic-acid-nephropathy
#3
Min Shi, Liang Ma, Li Zhou, Ping Fu
Aristolochic acid nephropathy (AAN) is a progressive kidney disease caused by a Chinese herb containing aristolochic acid. Excessive death of renal tubular epithelial cells (RTECs) characterized the acute phase of AAN. Therapies for acute AAN were limited, such as steroids and angiotensin-receptor blockers (ARBs)/angiotensin-converting enzyme inhibitors (ACEIs). It was interesting that, in acute AAN, female patients showed relative slower progression to renal failure than males. In a previous study, female hormone 17β-estradiol (E2) was found to attenuate renal ischemia-reperfusion injury...
October 18, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27759489/bio-inspired-artemether-loaded-human-serum-albumin-nanoparticles-for-effective-control-of-malaria-infected-erythrocytes
#4
Aditi A Sidhaye, Kanchan C Bhuran, Sneha Zambare, Munna Abubaker, Niroshini Nirmalan, Kamalinder K Singh
AIM: The intra-erythrocytic development of the malarial parasite is dependent on active uptake of nutrients, including human serum albumin (HSA), into parasitized red blood cells (pRBCs). We have designed HSA-based nanoparticles as a potential drug-delivery option for antimalarials. METHODS: Artemether-loaded nanoparticles (AANs) were designed and antimalarial activity evaluated in vitro/in vivo using Plasmodium falciparum/Plasmodium berghei species, respectively...
October 19, 2016: Nanomedicine
https://www.readbyqxmd.com/read/27750081/metabolomics-insights-into-activated-redox-signaling-and-lipid-metabolism-dysfunction-in-chronic-kidney-disease-progression
#5
Hua Chen, Gang Cao, Dan-Qian Chen, Ming Wang, Nosratola D Vaziri, Zhi-Hao Zhang, Jia-Rong Mao, Xu Bai, Ying-Yong Zhao
Early detection is critical in prevention and treatment of kidney disease. However currently clinical laboratory and histopathological tests do not provide region-specific and accurate biomarkers for early detection of kidney disease. The present study was conducted to identify sensitive biomarkers for early detection and progression of tubulo-interstitial nephropathy in aristolochic acid I-induced rats at weeks 4, 8 and 12. Biomarkers were validated using aristolochic acid nephropathy (AAN) rats at week 24, adenine-induced chronic kidney disease (CKD) rats and CKD patients...
September 28, 2016: Redox Biology
https://www.readbyqxmd.com/read/27731423/parental-vitamin-deficiency-affects-the-embryonic-gene-expression-of-immune-lipid-transport-and-apolipoprotein-genes
#6
Kaja H Skjærven, Lars Martin Jakt, John Arne Dahl, Marit Espe, Håvard Aanes, Kristin Hamre, Jorge M O Fernandes
World Health Organization is concerned for parental vitamin deficiency and its effect on offspring health. This study examines the effect of a marginally dietary-induced parental one carbon (1-C) micronutrient deficiency on embryonic gene expression using zebrafish. Metabolic profiling revealed a reduced 1-C cycle efficiency in F0 generation. Parental deficiency reduced the fecundity and a total of 364 genes were differentially expressed in the F1 embryos. The upregulated genes (53%) in the deficient group were enriched in biological processes such as immune response and blood coagulation...
October 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27694261/the-aan-s-axon-registry-mastering-how-we-are-measured
#7
Neil A Busis, Gary M Franklin
No abstract text is available yet for this article.
September 30, 2016: Neurology
https://www.readbyqxmd.com/read/27626377/broad-histone-h3k4me3-domains-in-mouse-oocytes-modulate-maternal-to-zygotic-transition
#8
John Arne Dahl, Inkyung Jung, Håvard Aanes, Gareth D Greggains, Adeel Manaf, Mads Lerdrup, Guoqiang Li, Samantha Kuan, Bin Li, Ah Young Lee, Sebastian Preissl, Ingunn Jermstad, Mads Haugland Haugen, Rajikala Suganthan, Magnar Bjørås, Klaus Hansen, Knut Tomas Dalen, Peter Fedorcsak, Bing Ren, Arne Klungland
Maternal-to-zygotic transition (MZT) is essential for the formation of a new individual, but is still poorly understood despite recent progress in analysis of gene expression and DNA methylation in early embryogenesis. Dynamic histone modifications may have important roles in MZT, but direct measurements of chromatin states have been hindered by technical difficulties in profiling histone modifications from small quantities of cells. Recent improvements allow for 500 cell-equivalents of chromatin per reaction, but require 10,000 cells for initial steps or require a highly specialized microfluidics device that is not readily available...
September 14, 2016: Nature
https://www.readbyqxmd.com/read/27623708/residue-geometry-networks-a-rigidity-based-approach-to-the-amino-acid-network-and-evolutionary-rate-analysis
#9
Alexander S Fokas, Daniel J Cole, Sebastian E Ahnert, Alex W Chin
Amino acid networks (AANs) abstract the protein structure by recording the amino acid contacts and can provide insight into protein function. Herein, we describe a novel AAN construction technique that employs the rigidity analysis tool, FIRST, to build the AAN, which we refer to as the residue geometry network (RGN). We show that this new construction can be combined with network theory methods to include the effects of allowed conformal motions and local chemical environments. Importantly, this is done without costly molecular dynamics simulations required by other AAN-related methods, which allows us to analyse large proteins and/or data sets...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27619228/neurocritical-care-education-during-residency-opinions-neuron-study
#10
David P Lerner, Jennifer Kim, Saef Izzy
BACKGROUND: The American Academy of Neurology (AAN) has established a core curriculum of topics for residency training in neurocritical care. At present there is limited data evaluating neurology residency education within the neurological intensive care unit. This study evaluates learner concerns with the neurological intensive care unit. METHODS: The Communication Committee and Resident & Fellow Taskforce within the Neurocritical Care Society (NCS) developed an online survey that consisted of 20 selection and free-text based questions...
September 12, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/27616758/the-effect-of-gender-on-aminoglycoside-associated-nephrotoxicity%C3%A2
#11
Joel Neugarten, Ladan Golestaneh
AIMS: The kidney disease improving global outcomes (KDIGO) clinical practice guidelines for acute kidney injury (AKI) has endorsed the widely held belief that female gender is a risk factor for aminoglycoside-associated nephrotoxicity (AAN). In contrast, female gender is protective in animal models. In light of this dichotomy, we sought to explore this relationship in greater detail. METHODS: We performed a meta-analysis of studies published between 1978 and 2015 which examined aminoglycoside nephrotoxicity and provided gender-specific data...
October 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27569016/-intermittent-explosive-disorder-a-controversial-diagnosis
#12
Juan Pablo Zapata, Juan David Palacio
INTRODUCTION: Intermittent explosive disorder (IED) is aan externalizing externalising disorder characterized characterised by recurrent aggression episodes. Even though this disorder was described several decades ago, and it carries personal and social consequences, there is little in the medical scientific literature on this. bibliographic production about it is scanty. OBJECTIVE: To perform a conceptualization conceptualisation of this disorder, through the review and bibliometric analysis of the available scientific articles...
July 2016: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/27557898/impact-of-genetic-modulation-of-sult1a-enzymes-on-dna-adduct-formation-by-aristolochic-acids-and-3-nitrobenzanthrone
#13
Volker M Arlt, Walter Meinl, Simone Florian, Eszter Nagy, Frantisek Barta, Marlies Thomann, Iveta Mrizova, Annette M Krais, Maggie Liu, Meirion Richards, Amin Mirza, Klaus Kopka, David H Phillips, Hansruedi Glatt, Marie Stiborova, Heinz H Schmeiser
Exposure to aristolochic acid (AA) causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN). Conflicting results have been found for the role of human sulfotransferase 1A1 (SULT1A1) contributing to the metabolic activation of aristolochic acid I (AAI) in vitro. We evaluated the role of human SULT1A1 in AA bioactivation in vivo after treatment of transgenic mice carrying a functional human SULT1A1-SULT1A2 gene cluster (i.e. hSULT1A1/2 mice) and Sult1a1(-/-) mice with AAI and aristolochic acid II (AAII)...
August 24, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27484504/phenotypic-and-functional-comparison-of-class-switch-recombination-deficiencies-with-a-subgroup-of-common-variable-immunodeficiencies
#14
Daan J Aan de Kerk, Machiel H Jansen, Stephen Jolles, Klaus Warnatz, Suranjith L Seneviratne, Ineke J M Ten Berge, Ester M M van Leeuwen, Taco W Kuijpers
Primary antibody deficiencies (PADs) are the most common immunodeficiency in humans, characterized by low levels of immunoglobulins and inadequate antibody responses upon immunization. These PADs may result from an early block in B cell development with a complete absence of peripheral B cells and lack of immunoglobulins. In the presence of circulating B cells, some PADs are genetically caused by a class switch recombination (CSR) defect, but in the most common PAD, common variable immunodeficiency (CVID), very few gene defects have as yet been characterized despite various phenotypic classifications...
October 2016: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/27475214/beam-diffraction-effects-in-sound-transmission-of-a-fluid-embedded-viscoelastic-plate-at-normal-incidence
#15
Magne Aanes, Kjetil Daae Lohne, Per Lunde, Magne Vestrheim
The characteristics of a sound beam transmitted through a fluid-embedded viscoelastic plate at normal incidence can deviate significantly from those of a plane-wave. Phenomena such as frequency shift, signal amplification or reduction, and changed beam properties, are observed for resonance peaks associated with specific leaky Lamb modes. When interpreting measurements using plane-wave theory, such deviations will influence the measurement of material parameters and plate thickness. The finite-element-based models used in this study describe the signal chain from the electrical voltage excitation at the piezoelectric transducer terminals to the sound pressure propagated through the plate and fluid to the position at which it is measured by a hydrophone...
July 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27449064/organ-support-after-death-by-neurologic-criteria-results-of-a-survey-of-us-neurologists
#16
Ariane Lewis, Nellie Adams, Panayiotis Varelas, David Greer, Arthur Caplan
OBJECTIVE: We sought to evaluate how neurologists approach situations in which families request prolonged organ support after declaration of death by neurologic criteria (DNC). METHODS: We surveyed 938 members of the American Academy of Neurology (AAN) who treat critically ill patients, including 50% who practice in states with accommodation exceptions (states that require religious or moral beliefs to be taken into consideration when declaring death or discontinuing organ support: California, Illinois, New Jersey, New York), and 50% who practice in nonaccommodation states...
August 23, 2016: Neurology
https://www.readbyqxmd.com/read/27432623/treatment-of-cluster-headache-the-american-headache-society-evidence-based-guidelines
#17
REVIEW
Matthew S Robbins, Amaal J Starling, Tamara M Pringsheim, Werner J Becker, Todd J Schwedt
BACKGROUND: Cluster headache (CH), the most common trigeminal autonomic cephalalgia, is an extremely debilitating primary headache disorder that is often not optimally treated. New evidence-based treatment guidelines for CH will assist clinicians with identifying and choosing among current treatment options. OBJECTIVES: In this systematic review we appraise the available evidence for the acute and prophylactic treatment of CH, and provide an update of the 2010 American Academy of Neurology (AAN) endorsed systematic review...
July 2016: Headache
https://www.readbyqxmd.com/read/27418141/bioinformatics-facilitating-the-use-of-microarrays-to-delineate-potential-mirna-biomarkers-in-aristolochic-acid-nephropathy
#18
Yana Lv, Yumei Que, Qiao Su, Qiang Li, Xi Chen, Haitao Lu
Aristolochic acid nephropathy (AAN) is a rapidly progressive acute or chronic tubulointerstitial nephritis (TIN). The present study attempted to explore the molecular mechanisms underlying the miRNA-directed development of AAN. Our differentially expressed analysis identified 11 DE-miRNAs and retrieved the target genes of these DE-miRNAs; then, network analysis and functional analysis further identified 6 DE-miRNAs (has-miR-192, has-miR-194, has-miR-542-3p, has-miR-450a, has-miR-584, has-miR-33a) as phenotypic biomarkers of AAN...
July 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27379382/blocking-tgf-%C3%AE-signaling-pathway-preserves-mitochondrial-proteostasis-and-reduces-early-activation-of-pdgfr%C3%AE-pericytes-in-aristolochic-acid-induced-acute-kidney-injury-in-wistar-male-rats
#19
Agnieszka A Pozdzik, Laetitia Giordano, Gang Li, Marie-Hélène Antoine, Nathalie Quellard, Julie Godet, Eric De Prez, Cécile Husson, Anne-Emilie Declèves, Volker M Arlt, Jean-Michel Goujon, Isabelle Brochériou-Spelle, Steven R Ledbetter, Nathalie Caron, Joëlle L Nortier
BACKGROUND: The platelet-derived growth factor receptor β (PDGFRβ)+ perivascular cell activation becomes increasingly recognized as a main source of scar-associated kidney myofibroblasts and recently emerged as a new cellular therapeutic target. AIMS: In this regard, we first confirmed the presence of PDGFRβ+ perivascular cells in a human case of end-stage aristolochic acid nephropathy (AAN) and thereafter we focused on the early fibrosis events of transforming growth factor β (TGFβ) inhibition in a rat model of AAN...
2016: PloS One
https://www.readbyqxmd.com/read/27376968/the-yeast-transcription-elongation-factor-spt4-5-is-a-sequence-specific-rna-binding-protein
#20
Amanda J Blythe, Berra Yazar-Klosinski, Michael W Webster, Eefei Chen, Marylène Vandevenne, Katerina Bendak, Joel P Mackay, Grant A Hartzog, Alice Vrielink
The heterodimeric transcription elongation factor Spt4/Spt5 (Spt4/5) tightly associates with RNAPII to regulate both transcriptional elongation and co-transcriptional pre-mRNA processing; however, the mechanisms by which Spt4/5 acts are poorly understood. Recent studies of the human and Drosophila Spt4/5 complexes indicate that they can bind nucleic acids in vitro. We demonstrate here that yeast Spt4/5 can bind in a sequence-specific manner to single stranded RNA containing AAN repeats. Furthermore, we show that the major protein determinants for RNA-binding are Spt4 together with the NGN domain of Spt5 and that the KOW domains are not required for RNA recognition...
September 2016: Protein Science: a Publication of the Protein Society
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