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https://www.readbyqxmd.com/read/29036902/dna-adducts-formed-by-aristolochic-acid-are-unique-biomarkers-of-exposure-and-explain-the-initiation-phase-of-upper-urothelial-cancer
#1
REVIEW
Marie Stiborová, Volker M Arlt, Heinz H Schmeiser
Aristolochic acid (AA) is a plant alkaloid that causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN), unique renal diseases frequently associated with upper urothelial cancer (UUC). This review summarizes the significance of AA-derived DNA adducts in the aetiology of UUC leading to specific A:T to T:A transversion mutations (mutational signature) in AAN/BEN-associated tumours, which are otherwise rare in individuals with UCC not exposed to AA. Therefore, such DNA damage produced by AA-DNA adducts is one rare example of the direct association of exposure and cancer development (UUC) in humans, confirming that the covalent binding of carcinogens to DNA is causally related to tumourigenesis...
October 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29026167/the-proteasome-inhibitor-bortezomib-attenuates-renal-fibrosis-in-mice-via-the-suppression-of-tgf-%C3%AE-1
#2
Moko Zeniya, Takayasu Mori, Naofumi Yui, Naohiro Nomura, Shintaro Mandai, Kiyoshi Isobe, Motoko Chiga, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
Kidney fibrosis and fibrogenesis significantly exacerbate chronic kidney disease (CKD) progression and are essential therapeutic targets. Bortezomib (BZM) is a proteasome inhibitor used for the treatment of multiple myeloma (MM). Several studies have demonstrated that BZM attenuates renal impairment in patients with MM, although this effect is generally considered to be the result of MM remission. Recently, several studies on BZM reported anti-fibrotic effects on liver and skin in experimental animal models...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28979016/alopecic-and-aseptic-nodules-of-the-scalp-with-trichoscopic-and-ultrasonographic-findings
#3
Anna Isabel Lázaro-Simó, Maribel Iglesias Sancho, Mònica Quintana-Codina, Elena Del Alcázar Viladomiu, Pau Umbert Millet, Montse Salleras Redonnet
Alopecic and aseptic nodules of the scalp (AANS) is a rare entity, etiology of which is already unknown. It consists of a few dome-shaped, skin-colored nodules associated with nonscarring alopecia. They are usually located in the upper part of the occiput and surrounded by normal scalp. Most of the times, a biopsy is performed to make an accurate diagnosis. AANS have a good prognosis and even can resolve spontaneously. We present a new case of this entity with the description of trichoscopic and ultrasonographic findings that have recently been reported...
September 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28965527/psychometrics-of-the-aan-caregiver-driving-safety-questionnaire-and-contributors-to-caregiver-concern-about-driving-safety-in-older-adults
#4
Janessa O Carvalho, Beth Springate, Rachel A Bernier, Jennifer Davis
BACKGROUND: The American Academy of Neurology (AAN) updated their practice parameters in the evaluation of driving risk in dementia and developed a Caregiver Driving Safety Questionnaire, detailed in their original manuscript (Iverson Gronseth, Reger, Classen, Dubinsky, & Rizzo, 2010). They described four factors associated with decreased driving ability in dementia patients: history of crashes or citations, informant-reported concerns, reduced mileage, and aggressive driving. METHOD: An informant-reported AAN Caregiver Driving Safety Questionnaire was designed with these elements, and the current study was the first to explore the factor structure of this questionnaire...
October 2, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28965423/treatment-of-tardive-dyskinesia-with-tetrabenazine-or-valbenazine-a-systematic-review
#5
Stanley N Caroff, Saurabh Aggarwal, Charles Yonan
Up to 30% of patients taking antipsychotics may develop tardive dyskinesia (TD). Recent evidence-based recommendations demonstrate an unmet need for effective TD management. This systematic review was designed to update the evidence for TD treatment, comparing two vesicular monoamine transporter 2 (VMAT2) inhibitors, tetrabenazine and valbenazine. Of 487 PubMed/Embase search results, 11 studies met the review criteria. Valbenazine efficacy was demonstrated in rigorously designed clinical trials that meet the guidelines for AAN Class I evidence...
October 2, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28863617/time-of-flight-dependency-on-transducer-separation-distance-in-a-reflective-path-guided-wave-ultrasonic-flow-meter-at-zero-flow-conditions
#6
Magne Aanes, Remi Andre Kippersund, Kjetil Daae Lohne, Kjell-Eivind Frøysa, Per Lunde
Transit-time flow meters based on guided ultrasonic wave propagation in the pipe spool have several advantages compared to traditional inline ultrasonic flow metering. The extended interrogation field, obtained by continuous leakage from guided waves traveling in the pipe wall, increases robustness toward entrained particles or gas in the flow. In reflective-path guided-wave ultrasonic flow meters (GW-UFMs), the flow equations are derived from signals propagating solely in the pipe wall and from signals passing twice through the fluid...
August 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28859703/sinus-bacteriology-in-patients-with-cystic-fibrosis-or-primary-ciliary-dyskinesia-a-systematic-review
#7
Maria E Møller, Mikkel C Alanin, Christian Grønhøj, Kasper Aanæs, Niels Høiby, Christian von Buchwald
BACKGROUND: A correlation exists between the microbial flora of the upper and lower airways in patients with cystic fibrosis (CF) or with primary ciliary dyskinesia (PCD). The sinuses can function as a bacterial reservoir where gram-negative bacteria adapt to the airways and repeatedly are aspirated to and colonize the lungs according to the theory of the united (unified) airways. Whereas the pattern of bacterial flora in the lower airways has been extensively studied, the upper airways have drawn limited attention...
September 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28852853/predicting-symptomatic-cerebral-vasospasm-after-aneurysmal-subarachnoid-hemorrhage-with-an-artificial-neural-network-in-a-pediatric-population
#8
Jesse Skoch, Rizwan Tahir, Todd Abruzzo, John M Taylor, Mario Zuccarello, Sudhakar Vadivelu
PURPOSE: Artificial neural networks (ANN) are increasingly applied to complex medical problem solving algorithms because their outcome prediction performance is superior to existing multiple regression models. ANN can successfully identify symptomatic cerebral vasospasm (SCV) in adults presenting after aneurysmal subarachnoid hemorrhage (aSAH). Although SCV is unusual in children with aSAH, the clinical consequences are severe. Consequently, reliable tools to predict patients at greatest risk for SCV may have significant value...
August 29, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28841844/acute-autonomic-neuropathy-with-severe-gastrointestinal-symptoms-in-children-a-case-series
#9
Ling-Yu Pang, Chang-Hong Ding, Yang-Yang Wang, Li-Ying Liu, Qiao-Jun Li, Li-Ping Zou
BACKGROUND: Acute autonomic neuropathy (AAN) is rare disorder with anecdotal report, especially for childhood onset patients. Misdiagnosis or delays in treatment can always be found in clinical practice. We conducted this study to give a description of the manifestations and treatment of AAN in children and therefore help clinicians to make the accurate diagnosis early so that the prognosis of the patients can be improved. METHODS: A systematic record from 3 clinical centers was used to identify 11 subject, 3 males and 8 females, with clinical diagnosed AAN...
August 25, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28832640/restored-nitric-oxide-bioavailability-reduces-the-severity-of-acute-to-chronic-transition-in-a-mouse-model-of-aristolochic-acid-nephropathy
#10
Inès Jadot, Vanessa Colombaro, Blanche Martin, Isabelle Habsch, Olivia Botton, Joëlle Nortier, Anne-Emilie Declèves, Nathalie Caron
Aristolochic Acid (AA) nephropathy (AAN) is a progressive tubulointerstitial nephritis characterized by an early phase of acute kidney injury (AKI) leading to chronic kidney disease (CKD). The reduced nitric oxide (NO) bioavailability reported in AAN might contribute to renal function impairment and progression of the disease. We previously demonstrated that L-arginine (L-Arg) supplementation is protective in AA-induced AKI. Since the severity of AKI may be considered a strong predictor of progression to CKD, the present study aims to assess the potential benefit of L-Arg supplementation during the transition from the acute phase to the chronic phase of AAN...
2017: PloS One
https://www.readbyqxmd.com/read/28813871/clinical-effectiveness-of-combined-virtual-reality-and-robot-assisted-fine-hand-motion-rehabilitation-in-subacute-stroke-patients
#11
Xianwei Huang, Fazel Naghdy, Golshah Naghdy, Haiping Du
Robot-assisted therapy is regarded as an effective and reliable method for the delivery of highly repetitive rehabilitation training in restoring motor skills after a stroke. This study focuses on the rehabilitation of fine hand motion skills due to their vital role in performing delicate activities of daily living (ADL) tasks. The proposed rehabilitation system combines an adaptive assist-as-needed (AAN) control algorithm and a Virtual Reality (VR) based rehabilitation gaming system (RGS). The developed system is described and its effectiveness is validated through clinical trials on a group of eight subacute stroke patients for a period of six weeks...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28794186/hfq-links-translation-repression-to-stress-induced-mutagenesis-in-e-coli
#12
Jiandong Chen, Susan Gottesman
Mismatch repair (MMR) is a conserved mechanism exploited by cells to correct DNA replication errors both in growing cells and under nongrowing conditions. Hfq (host factor for RNA bacteriophage Qβ replication), a bacterial Lsm family RNA-binding protein, chaperones RNA-RNA interactions between regulatory small RNAs (sRNAs) and target messenger RNAs (mRNAs), leading to alterations of mRNA translation and/or stability. Hfq has been reported to post-transcriptionally repress the DNA MMR gene mutS in stationary phase, possibly limiting MMR to allow increased mutagenesis...
August 9, 2017: Genes & Development
https://www.readbyqxmd.com/read/28793808/the-efficacy-and-feasibility-of-aquatic-physiotherapy-for-people-with-parkinson-s-disease-a-systematic-review
#13
Aan Fleur Terrens, Sze-Ee Soh, Prue Elizabeth Morgan
PURPOSE: To critically evaluate the literature regarding the efficacy and feasibility of aquatic physiotherapy in people with Parkinson's disease. METHOD: Relevant studies were identified through searches in nine health-related databases. Two independent reviewers assessed study quality using either the PEDro scale or a customised tool for safety and feasibility. RESULTS: Database searches yielded 88 articles, of which 10 met the inclusion criteria...
August 9, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28771804/palmar-eccrine-hidradenitis-secondary-to-trauma-from-computer-gaming-in-an-adolescent-after-bone-marrow-transplantation
#14
Lynette Ying Lee, Mark Jean-Aan Koh
A 14-year-old boy who had undergone a matched sibling bone marrow transplant for acute lymphoblastic leukemia presented with painful nodules on his palms after prolonged gaming on his computer and mobile phone. Histology showed a neutrophilic inflammatory infiltrate surrounding the acrosyringium and eccrine sweat coils in the deep dermis. The lesions resolved spontaneously with conservative management.
August 2, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28768842/developing-an-outline-for-teleneurology-curriculum-aan-telemedicine-work-group-recommendations
#15
Raghav Govindarajan, Eric R Anderson, Roger R Hesselbrock, Ramesh Madhavan, Lauren R Moo, Nima Mowzoon, James Otis, Mark N Rubin, Madhu Soni, Jack W Tsao, Scott Vota, Hannah Planalp
The emerging field of teleneurology is delivering quality care to neurologic patients in increasingly numerous technologies and configurations. Teleneurology is well-positioned to address many of the logistical issues neurologists and their patients encounter today. However, formalized medical training has not caught up with this developing field, and there is a lack of formal education concentrating on the specific opportunities and challenges of teleneurology. Considering this, the American Academy of Neurology Telemedicine Work Group identified equivalencies with which any practitioner of teleneurology should be familiar...
August 29, 2017: Neurology
https://www.readbyqxmd.com/read/28688271/agarose-based-large-molecular-systems-synthesis-of-fluorescent-aromatic-agarose-amino-acid-nano-conjugates-their-ph-stimulated-structural-variations-and-interactions-with-bsa
#16
Atul K Sharma, Nishith A Chudasama, Kamalesh Prasad, A K Siddhanta
Two new nano-sized fluorescent 6-amino agarose naphthalic acid half ester derivatives were synthesized (ca.60% yields) employing 1,8- and 2,3-naphthalic acid anhydrides (1,8-AANE, and 2,3-AANE respectively). These large nano molecular frameworks (DLS 3 & 100 nm, and 3 & 152 nm respectively) contains amino, naphthalate half-ester carboxyl groups at the C-6 positions of the 1,3-β-D-galactopyranose moieties of the agarose backbone (overall DS 0.94). Structures were characterized (FT-IR, and (13)C &(1)H NMR spectrometries)...
September 8, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28659784/effects-of-assist-as-needed-upper-extremity-robotic-therapy-after-incomplete-spinal-cord-injury-a-parallel-group-controlled-trial
#17
John Michael Frullo, Jared Elinger, Ali Utku Pehlivan, Kyle Fitle, Kathryn Nedley, Gerard E Francisco, Fabrizio Sergi, Marcia K O'Malley
BACKGROUND: Robotic rehabilitation of the upper limb following neurological injury has been supported through several large clinical studies for individuals with chronic stroke. The application of robotic rehabilitation to the treatment of other neurological injuries is less developed, despite indications that strategies successful for restoration of motor capability following stroke may benefit individuals with incomplete spinal cord injury (SCI) as well. Although recent studies suggest that robot-aided rehabilitation might be beneficial after incomplete SCI, it is still unclear what type of robot-aided intervention contributes to motor recovery...
2017: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/28651013/loss-of-prion-protein-induces-a-primed-state-of-type-i-interferon-responsive-genes
#18
Giulia Malachin, Malin R Reiten, Øyvind Salvesen, Håvard Aanes, Jorke H Kamstra, Kerstin Skovgaard, Peter M H Heegaard, Cecilie Ersdal, Arild Espenes, Michael A Tranulis, Maren K Bakkebø
The cellular prion protein (PrPC) has been extensively studied because of its pivotal role in prion diseases; however, its functions remain incompletely understood. A unique line of goats has been identified that carries a nonsense mutation that abolishes synthesis of PrPC. In these animals, the PrP-encoding mRNA is rapidly degraded. Goats without PrPC are valuable in re-addressing loss-of-function phenotypes observed in Prnp knockout mice. As PrPC has been ascribed various roles in immune cells, we analyzed transcriptomic responses to loss of PrPC in peripheral blood mononuclear cells (PBMCs) from normal goat kids (n = 8, PRNP+/+) and goat kids without PrPC (n = 8, PRNPTer/Ter) by mRNA sequencing...
2017: PloS One
https://www.readbyqxmd.com/read/28650809/beam-diffraction-effects-in-the-backward-wave-regions-of-viscoelastic-leaky-lamb-modes-for-plate-transmission-at-normal-incidence
#19
Magne Aanes, Kjetil Daae Lohne, Per Lunde, Magne Vestrheim
Plane-wave theory for fluid-embedded isotropic plates is often used in ultrasonic guided-wave applications, and to estimate wall thickness, corrosion, or sound velocities in plates and pipes. In such structures, measured ultrasonic transmission through the solid material is affected by acoustic beam diffraction effects, and the results may deviate from plane-wave descriptions, which are insufficient to describe the complex effects that occur. When exciting a fluid-embedded steel plate with a pulsed ultrasonic beam at normal incidence, resonance frequency downshift, axial sound pressure level increase, and beam narrowing have been observed, for measured resonance peaks in the frequency regions of certain leaky Lamb mode branches of the plate...
October 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28650003/american-academy-of-neurology-69th-annual-meeting-april-22-28-2017-boston-massachusetts-usa
#20
C Dulsat
The Annual Meeting of the American Academy of Neurology (AAN) is the largest conference convening neurology professionals from all over the world to share and discuss the latest breakthroughs in neurology treatment. The conference covers basic scientific research to clinical application through a wide range and interesting programs. This report covers some of the therapeutic highlights presented during the conference.
May 2017: Drugs of Today
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