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https://www.readbyqxmd.com/read/29454493/updating-the-recommendations-for-treatment-of-tardive-syndromes-a-systematic-review-of-new-evidence-and-practical-treatment-algorithm
#1
REVIEW
Roongroj Bhidayasiri, Onanong Jitkritsadakul, Joseph H Friedman, Stanley Fahn
BACKGROUND: Management of tardive syndromes (TS) is challenging, with only a few evidence-based therapeutic algorithms reported in the American Academy of Neurology (AAN) guideline in 2013. OBJECTIVE: To update the evidence-based recommendations and provide a practical treatment algorithm for management of TS by addressing 5 questions: 1) Is withdrawal of dopamine receptor blocking agents (DRBAs) an effective TS treatment? 2) Does switching from typical to atypical DRBAs reduce TS symptoms? 3) What is the efficacy of pharmacologic agents in treating TS? 4) Do patients with TS benefit from chemodenervation with botulinum toxin? 5) Do patients with TS benefit from surgical therapy? METHODS: Systematic reviews were conducted by searching PsycINFO, Ovid MEDLINE, PubMed, EMBASE, Web of Science and Cochrane for articles published between 2012 and 2017 to identify new evidence published after the 2013 AAN guidelines...
February 5, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29413819/caregiver-burden-and-illness-perceptions-in-caregivers-of-medically-hospitalized-youth-with-anorexia-nervosa
#2
Abigail Matthews, Katrina R Lenz, James Peugh, Emily C Copps, Claire M Peterson
Caregiver burden is common in caregivers of youth with anorexia nervosa (AN) and could impede the successful implementation of family-based therapy (FBT). Thus, it is important to better understand mechanisms by which caregiver burden is developed and maintained. This study aimed to examine the relation between caregiver illness perceptions about AN, symptom severity indicators, and caregiver burden in a sample of medically hospitalized youth with AN. Fifty-one youth with AN (N = 34) or Atypical AN (AAN; N = 17; mean age = 14...
February 1, 2018: Eating Behaviors
https://www.readbyqxmd.com/read/29408776/readability-and-quality-of-wikipedia-pages-on-neurosurgical-topics
#3
Omeed Modiri, Daipayan Guha, Naif M Alotaibi, George M Ibrahim, Nir Lipsman, Aria Fallah
OBJECTIVES: Wikipedia is the largest online encyclopedia with over 40 million articles, and generating 500 million visits per month. The aim of this study is to assess the readability and quality of Wikipedia pages on neurosurgical related topics. PATIENTS AND METHODS: We selected the neurosurgical related Wikipedia pages based on the series of online patient information articles that are published by the American Association of Neurological Surgeons (AANS). We assessed readability of Wikipedia pages using five different readability scales (Flesch Reading Ease, Flesch Kincaid Grade Level, Gunning Fog Index, SMOG) Grade level, and Coleman-Liau Index)...
January 29, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29408357/evidence-on-botulinum-toxin-in-selected-disorders
#4
Simpson, Elina Zakin
Botulinum toxin (BoNT) is a neurotoxin produced by the bacteria Clostridium botulinum that has become widely used for various neurologic indications. The four toxin formulations currently available for use in the United States (approved by the Food and Drug Administration) are onabotulinumtoxinA (Botox®), abobotulinumtoxinA (Dysport®), incobotulinumtoxinA (Xeomin®), and rimabotulinumtoxinB (Myobloc®). While the FDA-approved labels indicate that potency conversions should not be done, literature supports relative dose equivalents of approximately 1:1:2-4:50-100, respectively...
February 3, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29343469/entrustable-professional-activities-a-useful-concept-for-neurology-education
#5
Holli Horak, Robert Englander, Diana Barratt, Jeff Kraakevik, Madhu Soni, Ezgi Tiryaki
Medical education is currently undergoing a paradigm shift from process-based to competency-based education, focused on measuring the desired competence of a physician. In an attempt to improve the assessment framework used for medical education, the concept of entrustable professional activities (EPAs) has gained traction. EPAs are defined as professional activities that can be entrusted to an individual in a clinical context. The Association of American Medical Colleges (AAMC) defined a set of 13 such EPAs to define the core of what all students should be able to do on day 1 of residency, regardless of specialty choice...
January 17, 2018: Neurology
https://www.readbyqxmd.com/read/29298786/compound-heterozygous-mutations-with-novel-missense-abca12-mutation-in-harlequin-ichthyosis
#6
Benny Kai Guo Loo, Melissa Jeanne Batilando, Ene Choo Tan, Mark Jean Aan Koh
Harlequin ichthyosis (HI) is the most severe form of autosomal recessive congenital ichthyosis, presenting at birth with distinctive facial features and thick, plate-like scales over the entire body. The abnormal skin barrier predisposes the patient to multiple complications, including dehydration and sepsis. Mortality rates of babies with HI have been greatly reduced since the introduction of systemic retinoid therapy. Mutations in ABCA12 have been found to lead to HI. Most of these mutations are truncation or deletion mutations in the conserved region of the protein, leading to severe loss of ABCA12 function...
January 3, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29288843/collin-s-maccarty-1915-2003-inventor-of-the-maccarty-keyhole-as-the-starting-burr-hole-for-orbitozygomatic-craniotomy
#7
REVIEW
Fareed Jumah, Nimer Adeeb, Rimal Hanif Dossani
INTRODUCTION: Dr. Collin S. MacCarty (1915-2003) invented the MacCarty keyhole, which is now widely used as the starting burr hole for orbitozygomatic craniotomy. We present a historical vignette on MacCarty's life and chronicle his contributions to neurosurgery. METHODS: A detailed search for articles relating to the biography and professional career of Dr. MacCarty was conducted on PubMed and Google Scholar using the keywords "Collin MacCarty" and "MacCarty keyhole"...
December 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29282327/practice-guideline-update-summary-mild-cognitive-impairment-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology
#8
Ronald C Petersen, Oscar Lopez, Melissa J Armstrong, Thomas S D Getchius, Mary Ganguli, David Gloss, Gary S Gronseth, Daniel Marson, Tamara Pringsheim, Gregory S Day, Mark Sager, James Stevens, Alexander Rae-Grant
OBJECTIVE: To update the 2001 American Academy of Neurology (AAN) guideline on mild cognitive impairment (MCI). METHODS: The guideline panel systematically reviewed MCI prevalence, prognosis, and treatment articles according to AAN evidence classification criteria, and based recommendations on evidence and modified Delphi consensus. RESULTS: MCI prevalence was 6.7% for ages 60-64, 8.4% for 65-69, 10.1% for 70-74, 14.8% for 75-79, and 25.2% for 80-84...
January 16, 2018: Neurology
https://www.readbyqxmd.com/read/29226064/an-exploratory-study-of-illegal-gamblers-in-hong-kong
#9
Andrew Tessler, Kareen El Beyrouty, Natasha Crapnell
This study investigates the nature and behaviour of illegal gamblers in Hong Kong. A face-to-face street survey of 512 gamblers was conducted in Hong Kong between September and December 2015 with supplementary convenience sampling allowing for analysis of a total sample of 103 illegal gamblers. 56% of illegal gamblers recorded results consistent with this study's definition of 'excessive gambling' [i.e. moderate risk and problem gamblers under the Problem Gambling Severity Index (PGSI)]. 81% of surveyed illegal gamblers were male, 77% were aged between 30 and 49 and 67% were in blue collar occupations...
2017: Asian Journal of Gambling Issues and Public Health
https://www.readbyqxmd.com/read/29215709/the-potential-role-of-aquaporin-1-on-aristolochic-acid-i-induced-epithelial-mesenchymal-transition-on-hk-2-cells
#10
Ji Li, Mincheng Zhang, Yong Mao, Yimao Li, Xiaoxia Zhang, Xuehan Peng, Feng Yu
Aristolochic acid I (AA-I), one of the main active components in Aristolochaia herbs, may induce aristolochic acid nephropathy (AAN). Renal interstitial fibrosis is one of the most typical features of AAN. To investigate the mechanism of Aristolochic acid I (AA-I) -induced renal epithelial-mesenchymal transition (EMT) and determine the role of aquaporin-1 (AQP1) in this process, we established an AA-I-induced EMT model in human proximal tubular epithelial cells (HK-2 cells). Morphological examination, MTT assay, and Western blot analysis were performed...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29191125/the-2017-aans-presidential-address-a-world-of-innovation
#11
Frederick A Boop
The 2016 scientific meeting of the American Association of Neurological Surgeons (AANS) focused on the theme "A World of Innovation." In his presidential address, 2016 AANS President Frederick Boop compared the historical development of the specialty of neurological surgery with that of the development of global communications. In the early years, general surgeons training in the United States would spend post-residency time abroad learning from surgical masters in Europe and other places. Since Harvey Cushing's day, neurosurgeons from around the world continue to travel abroad, with many now coming to America for training at centers of excellence...
December 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29176640/identification-of-differentially-expressed-mirnas-in-the-fatty-liver-of-landes-goose-anser-anser
#12
Fang Chen, Hao Zhang, Jinjun Li, Yong Tian, Jing Xu, Li Chen, Jintao Wei, Na Zhao, Xuehai Yang, Wei Zhang, Lizhi Lu
Unlike mammals, in palmipedes de novo lipogenesis from diet takes place mostly in the liver. The French Landes Goose is famous for its high capacity and susceptibility to fatty liver production. While miRNAs play a critical role in the posttranscriptional regulation of gene expression, miRNAs that are involved in the regulation of goose hepatic steatosis have yet to be elucidated. Using high-throughput sequencing, we analyzed miRNAs expression profile of Landes goose liver after overfeeding for 21 days. Aan-miR-122-5p was the most frequently sequenced known miRNA, but it was unchanged after overfeeding...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29156918/challenges-and-ethical-issues-in-the-course-of-palliative-care-management-for-people-living-with-advanced-neurologic-diseases
#13
Varun Sreenivasan, Christa O'Hana S Nobleza
In the recent years, there has been an increase in awareness with regards to the role of palliative care (PC) in management of neurologic diseases. In 1996, the need to incorporate PC in the care for patients with neurologic conditions was recognized by the American Academy of Neurology (AAN) Ethics and Humanities Subcommittee. The gaps in research, education and the ability to deliver adequate PC were then acknowledged by the National Academy of Sciences with their publication of "Approaching death: improving care at the end of life" and most recently, continued goals in improving PC was highlighted by another recent publication "Dying in America: improving quality and honoring individual preferences near the end of life"...
October 19, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29101248/increased-circulating-interleukin-8-in-patients-with-resistance-to-thyroid-hormone-receptor-%C3%AE
#14
Anne H van der Spek, Olga V Surovtseva, Saskia Aan, Anton T J Tool, Annemarie van de Geer, Korcan Demir, Anja L M van Gucht, A S Paul van Trotsenburg, Timo K van den Berg, Eric Fliers, Anita Boelen
Innate immune cells have recently been identified as novel thyroid hormone (TH) target cells in which intracellular TH levels appear to play an important functional role. The possible involvement of TH receptor alpha (TRα), which is the predominant TR in these cells, has not been studied to date. Studies in TRα(0/0) mice suggest a role for this receptor in innate immune function. The aim of this study was to determine whether TRα affects the human innate immune response. We assessed circulating interleukin-8 concentrations in a cohort of 8 patients with resistance to TH due to a mutation of TRα (RTHα) and compared these results to healthy controls...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29076412/efficacy-duration-and-timing-of-withdrawal-of-prophylactic-treatment-with-antiepileptic-drugs-in-neurosurgical-conditions
#15
Daniel R Calnan, Erin D'Agostino, Matthew R Reynolds, Kimon Bekelis
Seizure control is a critical component of care in many neurosurgical conditions. The development of seizures in patients without a previously identified seizure disorder occurs in a significant proportion of traumatic brain injury, subarachnoid hemorrhage, and brain tumor patients. In this literature review and synthesis, we will discuss the incidence of seizures in selected conditions, indications and evidence for the initiation of antiepileptic drugs (AEDs), suggested duration of usage for AEDs, and current AED guidelines by the American Academy of Neurology (AAN), Congress of Neurological Surgeons (CNS), American Academy of Neurological Surgeons (AANS) and international committees...
October 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29074422/suboccipital-craniotomy-versus-craniectomy-a-survey-of-practice-patterns
#16
Elizabeth N Kuhn, Gustavo Chagoya, Bonita S Agee, Mark R Harrigan
OBJECT: Open surgical access to the posterior fossa has traditionally been achieved by permanent bone removal and remains the mainstay of posterior fossa surgery, although craniotomy is an alternative. Considerable variation exists at both the national and international levels within a variety of neurological and neurosurgical disciplines. In this study we surveyed current practice patterns regarding preference of suboccipital craniotomy or craniectomy. METHODS: The membership directory of the American Academy of Neurological Surgeons (AANS) was reviewed...
October 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29068241/strategic-voices-of-care-and-compassion-describing-the-mad-their-afflictions-and-situations-in-amsterdam-and-utrecht-in-the-seventeenth-and-eighteenth-centuries
#17
Ma Martje Aan de Kerk
Painting a picture of the lives of the early modern mad outside institutions has not yet been done in the Netherlands. However, by looking at notarial documents and admission requests, we can learn more about how the mad were cared for outside the institutions, and the impact their behaviour had on the people close to them. Investigating these sources for both Amsterdam and Utrecht in the seventeenth and eighteenth centuries has unravelled a story of community care in which families played a key role and used their options strategically...
October 1, 2017: History of Psychiatry
https://www.readbyqxmd.com/read/29061451/training-neurosurgery-and-radiation-oncology-residents-in-stereotactic-radiosurgery-an-assessment-gathered-from-participants-in-the-aans-and-astro-training-course
#18
Jason Sheehan, John H Suh, Brian Kavanagh, Zhiyuan Xu, Lydia Ren, Kimball Sheehan, L Dade Lunsford
OBJECTIVE: Stereotactic radiosurgery (SRS) represents an expanding approach for neurosurgeons and radiation oncologists. We evaluate educational gaps of senior residents drawn from each specialty as part of a focused SRS course. We also evaluate the strengths and limitations of SRS training in current residency programs of the course residents and faculty. METHODS: The AANS and ASTRO jointly held a senior resident course in SRS. Residents were nominated by program directors from across the U...
October 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29057728/-a-multidisciplinary-approach-in-diabetic-foot-disease-is-mandatory
#19
J G van Baal, W B Aan de Stegge, N C Schaper
The history of two patients (66- and 53-year-old males) with diabetes and peripheral neuropathy illustrates the variety of clinical presentations and pitfalls in treatment of diabetic foot ulcers. Peripheral arterial disease and mechanical stress as a consequence of peripheral neuropathy are important risk factors for developing an ulcer and eventually loss of a limb. Revascularisation of the limb should be considered in the presence of critical limb ischaemia or in the presence of mild to severe ischaemia in combination with a deep infection...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29047754/scene-reassembly-after-multimodal-digitization-and-pipeline-evaluation-using-photorealistic-rendering
#20
Jonathan Dyssel Stets, Alessandro Dal Corso, Jannik Boll Nielsen, Rasmus Ahrenkiel Lyngby, Sebastian Hoppe Nesgaard Jensen, Jakob Wilm, Mads Brix Doest, Carsten Gundlach, Eythor Runar Eiriksson, Knut Conradsen, Anders Bjorholm Dahl, Jakob Andreas Bærentzen, Jeppe Revall Frisvad, Henrik Aanæs
Transparent objects require acquisition modalities that are very different from the ones used for objects with more diffuse reflectance properties. Digitizing a scene where objects must be acquired with different modalities requires scene reassembly after reconstruction of the object surfaces. This reassembly of a scene that was picked apart for scanning seems unexplored. We contribute with a multimodal digitization pipeline for scenes that require this step of reassembly. Our pipeline includes measurement of bidirectional reflectance distribution functions and high dynamic range imaging of the lighting environment...
September 20, 2017: Applied Optics
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