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https://www.readbyqxmd.com/read/28548107/current-controversies-in-brain-death-determination
#1
REVIEW
Ariane Lewis, David Greer
Although the concept of brain death is accepted by the majority of physicians, lawyers, ethicists and society at large, controversies about determination of death by neurological criteria persist, and often reach the public eye. In this article, we examine four prominent controversial brain death cases from 2013-2016. We review current controversies, including protocol variability, recognition of the American Academy of Neurology (AAN) criteria for brain death as an accepted medical standard, and management of objections to discontinuation of organ support after determination of brain death...
May 26, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28543755/comparison-of-two-formulations-of-topical-timolol-for-the-treatment-of-infantile-hemangiomas
#2
Michelle Si Ying Ng, Yong-Kwang Tay, Shanna Shan-Yi Ng, Alice Yee Wah Foong, Mark Jean-Aan Koh
This report compares the efficacy of timolol maleate 0.5% eyedrops (TM) with that of timolol maleate 0.5% ophthalmic gel-forming solution in the treatment of infantile hemangiomas (IHs). Sixty-six patients undergoing treatment with topical timolol were retrospectively reviewed; our results revealed similar therapeutic efficacies for both types of timolol formulations. Early treatment initiation (<3 mos) and superficial lesions correlated with better treatment response. TM eyedrops may be a more cost effective, equally efficacious modality of treatment for IHs...
May 25, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28542233/is-survival-improved-by-the-use-of-niv-and-peg-in-amyotrophic-lateral-sclerosis-als-a-post-mortem-study-of-80-als-patients
#3
Christian Burkhardt, Christoph Neuwirth, Andreas Sommacal, Peter M Andersen, Markus Weber
BACKGROUND: Non-invasive ventilation (NIV) and percutaneous gastrostomy (PEG) are guideline-recommended interventions for symptom management in amyotrophic lateral sclerosis (ALS). Their effect on survival is controversial and the impact on causes of death is unknown. OBJECTIVE: To investigate the effect of NIV and PEG on survival and causes of death in ALS patients. METHODS: Eighty deceased ALS patients underwent a complete post mortem analysis for causes of death between 2003 and 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28529766/genome-wide-profiling-of-dna-5-hydroxymethylcytosine-during-rat-sertoli-cell-maturation
#4
Miriam Landfors, Jostein Johansen, Jan Magnus Aronsen, Cathrine Broberg Vågbø, Louis C Doré, Chuan He, Ivar Sjaastad, Pål Sætrom, Péter Fedorcsák, John Arne Dahl, Håvard Aanes, Markus Fußer, Arne Klungland
Sertoli cells have dual roles during the cells' lifetime. In the juvenile mammal, Sertoli cells proliferate and create the structure of the testis, and during puberty they cease to proliferate and take on the adult role of supporting germ cells through spermatogenesis. Accordingly, many genes expressed in Sertoli cells during testis formation are repressed during spermatogenesis. 5-Hydroxymethylcytosine (5hmC) is a DNA modification enzymatically generated from 5mC and present in all investigated mammalian tissues at varying levels...
2017: Cell Discovery
https://www.readbyqxmd.com/read/28524788/state-of-global-pediatric-neurosurgery-outreach-survey-by-the-international-education-subcommittee
#5
Matthew C Davis, Brandon G Rocque, Ash Singhal, Thomas Ridder, Jogi V Pattisapu, James M Johnston
OBJECTIVE Neurosurgical services are increasingly recognized as essential components of surgical care worldwide. The degree of interest among neurosurgeons regarding international work, and the barriers to involvement in global neurosurgical outreach, are largely unexplored. The authors distributed a survey to members of the American Association of Neurological Surgeons/Congress of Neurological Surgeons (AANS/CNS) Joint Section on Pediatric Neurosurgery to assess the state of global outreach among its members and to identify barriers to involvement...
May 19, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28524172/in-the-news-clinical-trials-excite-at-aan-2017
#6
Charlotte Ridler
No abstract text is available yet for this article.
May 19, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28521026/tracking-career-paths-of-women-in-neurosurgery
#7
Jaclyn J Renfrow, Analiz Rodriguez, Taylor A Wilson, Isabelle M Germano, Aviva Abosch, Stacey Quintero Wolfe
BACKGROUND: Women represent a growing cohort of US neurosurgeons. OBJECTIVE: To describe postresidency fellowship, practice environment, and updated academic rank among female neurosurgeons. METHODS: Databases from the American Association of Neurological Surgeons (AANS) and the American Board of Neurological Surgery (ABNS) from 1964 to 2013 were reviewed for female neurosurgery residency graduates. Data on postresidency fellowships, practice environment (private vs academic), academic rank, board certification, and AANS/CNS (Congress of Neurological Surgeons) Joint Section on Women in Neurosurgery (WINS) membership were collected in 2016...
May 16, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28504581/bacillus-coagulans-gbi-30-6086-increases-plant-protein-digestion-in-a-dynamic-computer-controlled-in-vitro-model-of-the-small-intestine-tim-1
#8
D Keller, R Van Dinter, H Cash, S Farmer, K Venema
The aim of this study was to assess the potential of the probiotic Bacillus coagulans GBI-30, 6086 [GanedenBC(30)] (BC30) to aid in protein digestion of alimentary plant proteins. To test this, three plant proteins, from pea, soy and rice, were digested in a validated in vitro model of the stomach and small intestine (TIM-1) in the absence and in the presence of BC30. Samples were taken from the TIM-1 fractions that mimic uptake of amino acids by the host and analysed for α-amino nitrogen (AAN) and total nitrogen (TN)...
May 15, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28501882/-caries-in-deprived-areas-2-youngsters
#9
G H W Verrips, J H Vermaire, C M H H van Houtem, C P F van Kempen, A A Schuller
In the Netherlands, no epidemiologic data on the oral health of cultural groups of children and adolescents living in deprived areas are available. The aim of the present study was to obtain an impression of the amount of caries experience among poorly educated groups of youngsters in deprived areas, in comparison with a reference group of poorly educated youngsters from the cities of Alphen aan den Rijn, Gouda, 's-Hertogenbosch and Breda. 725 Poorly educated respondents participated in a clinical and sociological study...
May 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28477152/revisiting-grade-3-diffuse-axonal-injury-not-all-brainstem-microbleeds-are-prognostically-equal
#10
Saef Izzy, Nicole L Mazwi, Sergi Martinez, Camille A Spencer, Joshua P Klein, Gunjan Parikh, Mel B Glenn, Steven M Greenberg, David M Greer, Ona Wu, Brian L Edlow
BACKGROUND: Recovery of functional independence is possible in patients with brainstem traumatic axonal injury (TAI), also referred to as "grade 3 diffuse axonal injury," but acute prognostic biomarkers are lacking. We hypothesized that the extent of dorsal brainstem TAI measured by burden of traumatic microbleeds (TMBs) correlates with 1-year functional outcome more strongly than does ventral brainstem, corpus callosal, or global brain TMB burden. Further, we hypothesized that TMBs within brainstem nuclei of the ascending arousal network (AAN) correlate with 1-year outcome...
May 5, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28443430/around-the-world
#11
(no author information available yet)
1 10th Dutch North Sea Emergency Medicine Conference 7-9 June, Egmond aan Zee, Netherlands tinyurl.com/10th-dutch-EM.
April 26, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28436084/defining-significant-weight-loss-in-atypical-anorexia-nervosa
#12
K Jean Forney, Tiffany A Brown, Lauren A Holland-Carter, Grace A Kennedy, Pamela K Keel
OBJECTIVE: Atypical anorexia nervosa (AAN) is defined by the symptoms of anorexia nervosa in the presence of "significant weight loss" in individuals who are not underweight. Description of current weight in AAN has been limited, significant weight loss has not been defined, and the distinction between having AAN versus having weight suppression has not been examined. METHOD: Secondary analyses were conducted with data from an epidemiological study of women (n = 1,640) and men (n = 794)...
April 24, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28435320/identification-prevalence-and-treatment-of-painful-diabetic-neuropathy-in-patients-from-a-rural-area-in-south-carolina
#13
Jimmy Pruitt, Carolina Moracho-Vilrriales, Tiffaney Threatt, Sarah Wagner, Jun Wu, E Alfonso Romero-Sandoval
Diabetic peripheral neuropathy (DPN) represents significant burdens to many patients and the public health-care system. Patients with diabetes in rural areas have higher risk of developing complications and having less access to proper treatment. We studied a rural population of patients with diabetes who attended a pharmacist-led free clinic for a diabetic education program. Our objectives were to 1) determine the prevalence of DPN and painful diabetic neuropathy (p-DN) in patients with type 2 diabetes; 2) assess the proportion of patients with DPN and p-DN left undocumented upon physician referral to a pharmacist-led free clinic; and 3) determine the appropriateness of pain medication regimen...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28421124/dahuang-fuzi-decoction-attenuates-renal-fibrosis-and-ameliorates-mitochondrial-dysfunction-in-chronic-aristolochic-acid-nephropathy
#14
Guang-Xing Shui, Dong Sang, Xun Yin, Yun Cai, Wei Sun
Objectives. The effects of the traditional formula Dahuang Fuzi Decoction (DFD) on chronic aristolochic acid nephropathy (AAN) in mice and its underlying mechanisms were studied. Methods. Mice were randomly divided into the following six groups: the control group, the model group (AAN), the saline-treated group (AAN + vehicle), the normal dose DFD-treated group (AAN + NDFD), the high dose DFD-treated group (AAN + HDFD), and the rosiglitazone treated group (AAN + Rosi). After treating for 8 weeks, 24 h urine and blood samples were collected and the mice sacrificed to study the biochemical parameters associated with renal function...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28403711/around-the-world
#15
(no author information available yet)
1. Tenth Dutch North Sea Emergency Medicine Conference 7-9 June, Egmond aan Zee, the Netherlands tinyurl.com/10th-dutch-EM.
April 13, 2017: Emergency Nurse: the Journal of the RCN Accident and Emergency Nursing Association
https://www.readbyqxmd.com/read/28375913/bell-s-palsy
#16
Stephen G Reich
PURPOSE OF REVIEW: Bell's palsy is a common outpatient problem, and while the diagnosis is usually straightforward, a number of diagnostic pitfalls can occur, and a lengthy differential diagnosis exists. Recognition and management of Bell's palsy relies on knowledge of the anatomy and function of the various motor and nonmotor components of the facial nerve. Avoiding diagnostic pitfalls relies on recognizing red flags or features atypical for Bell's palsy, suggesting an alternative cause of peripheral facial palsy...
April 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28368236/2017-aans-annual-scientific-meeting-los-angeles-ca-%C3%A2-april-22-26-2017
#17
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28352638/variability-in-diagnosing-brain-death-at-an-academic-medical-center
#18
Ashutosh Pandey, Pradeep Sahota, Premkumar Nattanmai, Christopher R Newey
Objective. Research continues to highlight variability in hospital policy and documentation of brain death. The aim of our study was to characterize how strictly new guidelines of American Academy of Neurology (AAN) for death by neurological criteria were practiced in our hospital prior to appointment of neurointensivists. Method. This is a retrospective study of adults diagnosed as brain dead from 2011 to 2015. Descriptive statistics compared five categories: preclinical testing, neurological examination, apnea tests, ancillary test, and documentation of time of death...
2017: Neuroscience Journal
https://www.readbyqxmd.com/read/28341442/risk-factors-for-postoperative-delirium-after-colorectal-operation
#19
Frederik J van der Sluis, Pieter L Buisman, Mark Meerdink, Wouter B Aan de Stegge, Boudewijn van Etten, Geertruida H de Bock, Barbara L van Leeuwen, Robert A Pol
BACKGROUND: A clear understanding of risk factors for postoperative delirium helps in the selection of individuals who might benefit from targeted perioperative intervention. The aim of this study was to identify risk factors for postoperative delirium after colorectal operation for malignancy. METHODS: All consecutive patients who underwent elective or emergency operation because of malignancy of the colon, sigmoid, or rectum between 2009 and 2012 were included in this study...
March 2017: Surgery
https://www.readbyqxmd.com/read/28326547/behavioural-responses-to-facial-and-postural-expressions-of-emotion-an-interpersonal-circumplex-approach
#20
Marije Aan Het Rot, Violeta Enea, Ion Dafinoiu, Sorina Iancu, Steluţa A Taftă, Mariana Bărbuşelu
While the recognition of emotional expressions has been extensively studied, the behavioural response to these expressions has not. In the interpersonal circumplex, behaviour is defined in terms of communion and agency. In this study, we examined behavioural responses to both facial and postural expressions of emotion. We presented 101 Romanian students with facial and postural stimuli involving individuals ('targets') expressing happiness, sadness, anger, or fear. Using an interpersonal grid, participants simultaneously indicated how communal (i...
March 21, 2017: British Journal of Psychology
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