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Malignant effusion

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https://www.readbyqxmd.com/read/28213004/pharmacokinetic-evaluation-of-intrapleural-perfusion-with-hyperthermic-chemotherapy-using-cisplatin-in-patients-with-malignant-pleural-effusion
#1
Hirozo Sakaguchi, H Ishida, H Nitanda, N Yamazaki, K Kaneko, Kunihiko Kobayashi
OBJECTIVES: Malignant pleural effusion (MPE) has a poor prognosis. Most patients are treated with tube thoracostomy and sclerotherapy, although its success rate is around 64%. We have investigated intrapleural perfusion with hyperthermic chemotherapy (IPHC) using cisplatin in a study with a pharmacokinetic evaluation. METHODS: Patients with MPE, performance status of 0-1, possibility of good lung expansion and Cr<1.2mg/dL were treated with IPHC. The circuit was filled with 2000mL of normal saline containing cisplatin at a dose of 80mg/m(2)...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28207201/diagnostic-yield-of-cytopathology-in-evaluating-pericardial-effusions-clinicopathologic-analysis-of-419-specimens
#2
Jad Saab, Rana S Hoda, Navneet Narula, Syed A Hoda, Brian E Geraghty, Abu Nasar, Susan A Alperstein, Jeffrey L Port, Tamar Giorgadze
BACKGROUND: Pericardial effusions can cause considerable morbidity and potentially may lead to mortality. Malignant pericardial effusions are uncommon, and data on malignancies encountered in pericardial effusion cytology specimens are limited. METHODS: Relevant records of all pericardial effusions from January 2008 to September 2014 were examined and compared with pericardial biopsy results when performed. Discrepant cases were reviewed to determine the cause of the disagreement...
February 2017: Cancer
https://www.readbyqxmd.com/read/28203412/predictive-models-of-malignant-transudative-pleural-effusions
#3
Lucía Ferreiro, Francisco Gude, María E Toubes, Adriana Lama, Juan Suárez-Antelo, Esther San-José, Francisco Javier González-Barcala, Antonio Golpe, José M Álvarez-Dobaño, Carlos Rábade, Nuria Rodríguez-Núñez, Carla Díaz-Louzao, Luis Valdés
BACKGROUND: There are no firm recommendations when cytology should be performed in pleural transudates, since some malignant pleural effusions (MPEs) behave biochemically as transudates. The objective was to assess when would be justified to perform cytology on pleural transudates. METHODS: Consecutive patients with transudative pleural effusion (PE) were enrolled and divided in two groups: malignant and non-MPE. Logistic regression analysis was used to estimate the probability of malignancy...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28203169/recurrent-malignant-melanoma-presenting-as-isolated-pleural-metastases-in-a-patient-with-chronic-lymphocytic-leukemia
#4
Kartik Anand, Shashank Cingam, Prakash Peddi
Isolated pleural metastasis with pleural effusion is a rare occurrence in malignant melanoma. We report an unusual case of a patient with chronic lymphocytic leukemia (CLL) and recurrent pleural effusions. The pleural fluid cytology and immunohistochemistry profile were consistent with the diagnosis of CLL. However, chemotherapy with pentostatin, cyclophosphamide, and rituximab did not result in any meaningful clinical response. A video-assisted thoracoscopic surgery and biopsy of the affected nodular parietal layer of the pleura were consistent with malignant melanoma...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28197215/pleural-procedures-in-the-management-of-malignant-effusions
#5
REVIEW
Lucía Ferreiro, Juan Suárez-Antelo, Luis Valdés
Malignant pleural effusion (MPE) is common in clinical practice, and despite the existence of studies to guide clinical decisions, it often poses diagnostic and therapeutic dilemmas. Once it is diagnosed, median survival does not usually exceed 6 months. The management of these patients focuses on symptom relief since no treatments have been shown to increase survival to date. Conversely, poor management can shorten survival. The approach must be multidisciplinary and allow for individualized care. Initial diagnostic procedures should be minimally invasive and, according to the results and other factors, procedures of increasing complexity will be selecting...
January 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28195268/unusual-pleural-effusion-from-vulvar-squamous-cell-carcinoma-report-of-a-case-and-review-of-the-literature
#6
S Erra, G Patrucco, G Speranza, S Barbero, F Brucculeri, G Taverna
Vulvar tumors are not very common and account for about 4% of all cancers affecting the female genital organs. Frequently, malignant neoplasia of this site have squamous phenotype and the rare cases of metastasization are reported in the locoregional lymph nodes and in the surrounding organs. We report a case of metastasization of a vulvar squamous cell carcinoma in an unusual place such as the parietal pleura, in a relapsing patient that was submitted to a surgical vulvectomy the previous year.
September 2016: Pathologica
https://www.readbyqxmd.com/read/28190404/determinants-of-mortality-in-elderly-patients-with-tuberculosis-a-population-based-follow-up-study
#7
Y-F Yen, J-Y Feng, S-W Pan, P-H Chuang, V Y-F Su, W-J Su
Elderly individuals with tuberculosis (TB) are more likely to have a non-specific clinical presentation of TB and high mortality. However, factors associated with mortality in elderly TB patients have not been extensively studied. This retrospective cohort study aimed to identify factors associated with death among elderly Taiwanese with TB. All elderly patients with TB from 2006 to 2014 in Taipei, Taiwan, were included in a study. Multiple logistic regression was used to identify the factors associated with death in elderly TB patients...
February 13, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28186653/progression-of-cutaneous-plasmacytoma-to-plasma-cell-leukemia-in-a-dog
#8
Emily D Rout, Alba Maria M Shank, Angharad H K Waite, Andrea Siegel, Anne C Avery, Paul R Avery
A 5-year-old male neutered Bernese Mountain Dog was presented for cutaneous plasmacytoma, which was treated by surgical excision. Four months later, the dog developed multiple skin masses, hyphema, pericardial and mild bicavitary effusions, myocardial masses, and marked plasmacytosis in the peripheral blood. Circulating plasma cells expressed CD34 and MHC class II by flow cytometry. Immunocytochemistry demonstrated that these cells were strongly positive for multiple myeloma oncogene 1/interferon regulatory factor 4 (MUM-1) and weakly to moderately positive for Pax5...
February 10, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28180935/clinicopathological-features-and-microsurgical-outcomes-for-giant-pediatric-intracranial-tumor-in-60-consecutive-cases
#9
Ailing Guo, Vigneyshwar Suresh, Xianzhi Liu, Fuyou Guo
PURPOSE: Giant pediatric intracranial tumor (GPIT) remains to be a challenging disease with high morbidity and mortality. METHODS: The clinical data of 60 patients under 18 years of age operated on with GPIT (≥5 cm in diameter) were retrospectively analyzed. RESULTS: Gross total resection was achieved in 46 cases (77%) and subtotal resection was obtained in 14 cases (23%). Ninety percent (47/52) of the cases with obstructive hydrocephalus were resolved remarkably and only 10% (5/52) of the patients needed a ventriculoperitoneal shunt after tumor resection...
February 8, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28174489/alk-gene-expression-status-in-pleural-effusion-predicts-tumor-responsiveness-to-crizotinib-in-chinese-patients-with-lung-adenocarcinoma
#10
Zheng Wang, Xiaonan Wu, Xiaohong Han, Gang Cheng, Xinlin Mu, Yuhui Zhang, Di Cui, Chang Liu, Dongge Liu, Yuankai Shi
OBJECTIVE: The relationship between anaplastic lymphoma kinase (ALK) expression in malignant pleural effusion (MPE) samples detected only by Ventana immunohistochemistry (IHC) ALK (D5F3) and the efficacy of ALK-tyrosine kinase inhibitor therapy is uncertain. METHODS: Ventana anti-ALK (D5F3) rabbit monoclonal primary antibody testing was performed on 313 cell blocks of MPE samples from Chinese patients with advanced lung adenocarcinoma, and fluorescence in situ hybridization (FISH) was used to verify the ALK gene status in Ventana IHC ALK (D5F3)-positive samples...
December 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28156621/comparison-of-two-indwelling-pleural-catheter-types-for-malignant-pleural-effusions
#11
Sushilkumar Satish Gupta, Abhinav Binod Chandra
: 205 Background: Indwelling pleural catheter (IPC) placement is an alternative to chemical pleurodesis for malignant pleural effusion (MPE), a complication of advanced cancer. In 1997 an IPC was approved which uses vacuum bottles (VB) for drainage (PleurX, Becton, Dickinson and Company, Franklin Lakes, NJ), and later another IPC system, which employs a manually operated vacuum pump (VP) for drainage (Aspira, Bard Access Systems, Salt Lake City, UT). Most studies comparing IPC versus chemical pleurodesis used the VB IPC...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28146424/up-regulation-of-tumor-suppressor-genes-by-exogenous-dhc16-cer-contributes-to-its-anti-cancer-activity-in-primary-effusion-lymphoma
#12
Yueyu Cao, Jing Qiao, Zhen Lin, Jovanny Zabaleta, Lu Dai, Zhiqiang Qin
Primary effusion lymphoma (PEL) is a rare and highly aggressive B-cell malignancy with Kaposi's sarcoma-associated herpesvirus (KSHV) infection, while lack of effective therapies. Our recent data indicated that targeting the sphingolipid metabolism by either sphingosine kinase inhibitor or exogenous ceramide species induces PEL cell apoptosis and suppresses tumor progression in vivo. However, the underlying mechanisms for these exogenous ceramides "killing" PEL cells remain largely unknown. Based on the microarray analysis, we found that exogenous dhC16-Cer treatment affected the expression of many cellular genes with important functions within PEL cells such as regulation of cell cycle, cell survival/proliferation, and apoptosis/anti-apoptosis...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28144058/the-minimum-volume-of-pleural-fluid-required-to-diagnose-malignant-pleural-effusion-a-retrospective-study
#13
Huimin Wu, Rahul Khosla, Prashant K Rohatgi, Suman S Chauhan, Edina Paal, Wen Chen
BACKGROUND: Pleural fluid cytology is a quick and accurate method to diagnose malignant pleural effusions. The optimal volume of fluid for cytological analysis has not yet been identified, and clinical recommendation based on some published clinical experiences has been to send large volumes of fluid for cytological analysis. A quality improvement initiative at our institution was conducted to determine the volume of fluid sufficient for a diagnosis of malignant pleural effusion. MATERIALS AND METHODS: The study was approved by the Institutional Review Board...
January 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28140518/metabonomics-by-proton-nuclear-magnetic-resonance-in-human-pleural-effusions-a-route-to-discriminate-between-benign-and-malignant-pleural-effusions-and-to-target-small-molecules-as-potential-cancer-biomarkers
#14
Lucio Zennaro, Paola Vanzani, Lorenzo Nicolè, Rocco Cappellesso, Ambrogio Fassina
BACKGROUND: Cytopathology is a noninvasive and cost-effective method for detecting cancer cells in pleural effusions (PEs), although in many cases, the diagnostic performance is hindered by the paucity of significant cells or the lack of clear morphological criteria. This study presents the results of an omics approach to improving the diagnostic performance of PE cytology. METHODS: Metabolic profiling with proton nuclear magnetic resonance ((1) H-NMR) was performed for 92 PEs (44 malignant cases of 8 different cancers and 48 benign cases of 7 nonneoplastic conditions)...
January 31, 2017: Cancer
https://www.readbyqxmd.com/read/28139896/cytopathologic-analysis-of-pericardial-effusions-in-116-cases-implications-for-poor-prognosis-in-lung-cancer-patients-with-positive-interpretations
#15
Bing He, Zhen Yang, Peng Zhao, Yu-Jun Li, Ji-Gang Wang
BACKGROUND: Few studies have evaluated the cytology of pericardial effusions. The aim of this study is to investigate the etiologies of pericardial effusions and to establish the relationship between cytopathologic interpretations and outcome patterns among patients with pericardial effusions. METHODS: We identified 116 patients with pericardial effusions at a single institution over a 4-year period and carefully analyzed all available clinical documents, including clinical diagnoses, cytopathologic findings, and outcome patterns...
January 31, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28133284/-an-autopsy-case-of-an-elderly-patient-with-signet-ring-cell-carcinoma-of-the-breast-derived-from-lobular-carcinoma
#16
Gen Tsujio, Naoki Aomatsu, Seika Tei, Yoshihito Yamakoshi, En Wang, Daisuke Nagashima, Toshiki Hirakawa, Takehiko Iwauchi, Takafumi Nishii, Junya Morimoto, Kazunori Nakazawa, Yasutake Uchima, Hiroshi Harada, Kiyoshi Kawano, Kazuhiro Takeuchi
A 90-year-old woman was referred to our hospital because of abdominal distension and pretibial edema. No tumors were palpable in either breast. Her abdomen was distended and palpitation was noticed. Laboratory examination revealed hypercalcemia and elevated levels of tumor markers(PIVKA- II , CEA, CA19-9, SCC). Contrast-enhanced computed tomography(CT) showed pleural effusion and ascites, an approximately 17-mm high-contrast mass in the D area of the left breast, and osteolysis of the dorsal lumber spine. We initiated treatment for pleural effusion, ascites, and hypercalcemia...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28127951/diagnostic-value-of-soluble-b7-h4-and-carcinoembryonic-antigen-in-distinguishing-malignant-from-benign-pleural-effusion
#17
Xiaogang Jing, Fei Wei, Jing Li, Lingling Dai, Xi Wang, Liuqun Jia, Huan Wang, Lin An, Yuanjian Yang, Guojun Zhang, Zhe Cheng
OBJECTIVE: To explore the diagnostic value of joint detection of soluble B7-H4 (sB7-H4) and carcinoembryonic antigen (CEA) in identifying malignant pleural effusion (MPE) from benign pleural effusion (BPE). METHODS: 97 patients with pleural effusion specimens were enrolled from the First Affiliated Hospital of Zhengzhou University between June 2014 and December 2015. All cases were categorized into malignant pleural effusion group (n=55) and benign pleural effusion group (n=42) according to etiologies...
January 27, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28125148/use-of-indwelling-pleural-catheters-for-the-definitive-treatment-of-malignant-pleural-effusion
#18
Fernando Conrado Abrão, Igor Renato Louro Bruno de Abreu, Maria Gabriela Cavalcanti, José Franklin Soares Pompa-Filho
Objective: To evaluate the safety and feasibility of the use of indwelling pleural catheters (IPCs) in patients with malignant pleural effusion (MPE). Methods: We prospectively collected data from patients with MPE undergoing IPC placement between January of 2014 and July of 2015. All patients submitted to IPC placement had a life expectancy > 30 days, in accordance with the MPE treatment guidelines established by the British Thoracic Society. The data collected included gender, age, body mass index, primary cancer site, duration of IPC drainage, IPC-related complications, length of hospital stay, pleural effusion recurrence, and occurrence of spontaneous pleurodesis...
January 23, 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28124967/-a-rare-and-mortal-infection-agent-in-patients-with-hematological-malignancies-saprochaete-capitata
#19
Lale Aydın Kaynar, Zübeyde Nur Özkurt, Burcu Ülküden, Özlem Güzel Tunçcan, Gülbin Aygencel, Nalan Akyürek, Ayşe Kalkancı
Saprochaete capitata (formerly known as Geotrichum capitatum and Blastoschizomyces capitatus) is a rare invasive fungal agent that may lead to mortal clinical course in patients with hematological malignancies. This agent can be colonized in skin, lungs and intestines, and it can cause major opportunistic infections. Invasive systemic infections due to S.capitata have been reported in immunosuppressed patients. In this report, two patients with invasive S.capitata infections detected during the course of persistent neutropenic fever in acute leukemia, were presented...
October 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28124437/presence-of-pleural-effusion-is-associated-with-a-poor-prognosis-in-patients-with-epidermal-growth-factor-receptor-mutated-lung-cancer-receiving-tyrosine-kinase-inhibitors-as-first-line-treatment
#20
Tso-Fu Wang, Sung-Chao Chu, Jen-Jyh Lee, Gee-Gwo Yang, Wei-Han Huang, En-Ting Chang, Tissot Low, Yi-Feng Wu, Ruey-Ho Kao, Chih-Bin Lin
AIM: This study was conducted to evaluate the effect of clinical factors on the treatment outcomes of lung cancer patients with active epidermal growth factor receptor (EGFR) mutations treated by first-line tyrosine kinase inhibitors (TKIs). METHODS: Patients of stage IIIb or IV lung adenocarcinoma harboring mutated EGFR were enrolled between March 2010 and June 2014 and followed up until December 2015. The effects of various clinical features, such as age, sex, smoking history, EGFR mutation types, TKIs used, presence of pleural effusion, metastatic sites on progression-free survival (PFS) and overall survival (OS), were analyzed retrospectively...
January 26, 2017: Asia-Pacific Journal of Clinical Oncology
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