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Malignant effusion

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https://www.readbyqxmd.com/read/29917319/intrapleural-combination-therapy-with-lobaplatin-and-erythromycin-for-non-small-cell-lung-cancer-mediated-malignant-pleural-effusion
#1
Lisheng Xu, Benjie Wang, Meimei Gao, Yan Zhang, Qian Qi, Tao Li, Caiyu Li, Aihua Wang, Yu Li
BACKGROUND: Malignant pleural effusion is a common complication of non-small cell lung cancer (NSCLC); however, treatment options remain limited. This study evaluated the safety and efficacy of sequential intrapleural therapy with lobaplatin and erythromycin for NSCLC-mediated malignant pleural effusion. METHODS: Fifty-six patients with NSCLC complicated with malignant pleural effusion were recruited for a prospective single-arm study from December 2014 to 2016; one patient dropped out...
June 19, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29916720/early-and-delayed-phases-of-contrast-enhanced-ct-for-evaluating-patients-with-malignant-pleural-effusion-results-of-pairwise-comparison-by-multiple-observers
#2
Juan José Arenas-Jiménez, Elena García-Garrigós, Carmen Escudero-Fresneda, Marina Sirera-Matilla, Irene García-Pastor, Alberto Quirce-Vázquez, Mariana Planells-Alduvin
OBJECTIVE: To compare images from early and delayed phases of contrast-enhanced thoracic CT for assessing pleural thickening or nodules in a series of patients with malignant pleural effusions. METHODS: Blinded images from 36 patients with malignant pleural effusions showing pleural lesions in both early (35 s delayed) and delayed (70 s delayed) phases of thoracic and abdominal contrast-enhanced CT scan were retrospectively assessed by six observers. First, images were individually scored in a six-point scale grading the quality of visualization of pleural findings such as pleural thickening or nodules...
June 19, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29915964/endoscopic-ultrasound-guided-transesophageal-thoracentesis-for-minimal-pleural-effusion
#3
Surinder Singh Rana, Ravi Sharma, Rajesh Gupta
BACKGROUND: Pleural effusion is a common finding both in patients with benign and malignant diseases of pleura and lung with diagnostic thoracentesis establishing the diagnosis in the majority of cases. The diagnostic thoracentesis can be done either blindly or under the guidance of ultrasound or computed tomography. However, minimal pleural effusion is difficult to sample even under image guidance. Endoscopic ultrasound (EUS) is known to detect smaller volume of pleural effusion and, thus, can help in guiding thoracentesis...
June 19, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29908990/development-and-validation-of-response-markers-to-predict-survival-and-pleurodesis-success-in-patients-with-malignant-pleural-effusion-promise-a-multicohort-analysis
#4
Ioannis Psallidas, Nikolaos I Kanellakis, Stephen Gerry, Marie Laëtitia Thézénas, Philip D Charles, Anastasia Samsonova, Herbert B Schiller, Roman Fischer, Rachelle Asciak, Robert J Hallifax, Rachel Mercer, Melissa Dobson, Tao Dong, Ian D Pavord, Gary S Collins, Benedikt M Kessler, Harvey I Pass, Nick Maskell, Georgios T Stathopoulos, Najib M Rahman
BACKGROUND: The prevalence of malignant pleural effusion is increasing worldwide, but prognostic biomarkers to plan treatment and to understand the underlying mechanisms of disease progression remain unidentified. The PROMISE study was designed with the objectives to discover, validate, and prospectively assess biomarkers of survival and pleurodesis response in malignant pleural effusion and build a score that predicts survival. METHODS: In this multicohort study, we used five separate and independent datasets from randomised controlled trials to investigate potential biomarkers of survival and pleurodesis...
June 13, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29908988/malignant-pleural-effusions-will-promise-make-its-name-true
#5
Paul Baas, Sjaak Burgers
No abstract text is available yet for this article.
June 13, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29908089/morphology-quiz-identification-of-metastatic-cells-in-pleural-effusion
#6
Diane Frankel, Andrée Robaglia-Schlupp, Donatienne Bourlard, Elise Kaspi, Patrice Roll
Quiz related to cytological examination of pleural effusion in a patient with history of latero-thoracic malignant melanoma. This article is protected by copyright. All rights reserved.
June 16, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29904468/rapidly-progressing-lepidic-pulmonary-metastases-from-a-treated-poorly-differentiated-hepatocellular-carcinoma-demonstrating-new-pathologic-features-of-cholangiocarcinoma-a-potential-diagnostic-pitfall-that-may-mimic-pneumonia
#7
Partha Hota, Chandra Dass, Maruti Kumaran, Xiaofeng Zhao, Nirag Jhala, Scott Simpson
Although the lung is a common site for metastatic disease from extrathoracic malignancies, a pattern of lepidic growth of these metastases is considered rare. A 67-year-old man with a history of partial hepatectomy for hepatocellular carcinoma (HCC) presented to our hospital with dyspnea and a nonproductive cough. Chest radiographs and computed tomography imaging demonstrated consolidation in the right upper lobe and an ipsilateral pleural effusion. Findings were initially suspected to be secondary to infection, given the radiographic appearance and the rapid development from a normal computed tomography 3 months previously...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29903664/activation-and-propagation-of-tumor-infiltrating-lymphocytes-from-malignant-pleural-effusion-and-ascites-with-engineered-cells-for-costimulatory-enhancement
#8
Qiuping Xu, Jie Shao, Shu Su, Jia Wei, Fangjun Chen, Fanyan Meng, Yang Zhao, Juan Du, Zhengyun Zou, Xiaoping Qian, Baorui Liu
Adoptive cell therapy (ACT) of autologous tumor-infiltrating lymphocytes (TILs) has shown an effect on mediating tumor regression in some patients with highly advanced, refractory metastatic malignancy. Here, the in vitro generation of TILs isolated from malignant pleural effusion and ascites was compared with which using engineered cells for costimulatory enhancement (ECCE) and 3 common γ-chain cytokines, interleukin (IL)-2, IL-7, and IL-15, alone or in combination. We showed the robust clinical-scale production of TILs with a less differentiated 'young' phenotype by expansion in the presence of ECCE combined with IL-2/7/15...
April 17, 2018: Cellular Immunology
https://www.readbyqxmd.com/read/29900179/chest-ultrasonography-to-assess-the-kinetics-and-efficacy-of-talc-pleurodesis-in-a-model-of-pneumothorax-an-experimental-animal-study
#9
Rachid Tazi-Mezalek, Diane Frankel, Marc Fortin, Elise Kaspi, Julien Guinde, Alexandra Assolen, Sophie Laroumagne, Andree Robaglia, Herve Dutau, Patrice Roll, Philippe Astoul
Talc pleurodesis is used to avoid recurrences in malignant pleural effusions or pneumothorax. The lack of lung sliding detected by chest ultrasonography (CUS) after talc application is indicative of the effectiveness of pleurodesis. The objective of our study was to explore, in an animal model, the capacity of CUS to predict the quality of a symphysis induced by talc poudrage (TP) and talc slurry (TS). We induced an artificial pneumothorax in six healthy pigs prior to talc application. TP was performed on one hemithorax, followed by TS on the other side 1 week later...
April 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29899086/modulation-of-cellular-cpg-dna-methylation-by-kaposi-s-sarcoma-associated-herpesvirus
#10
Guy Journo, Carmel Tushinsky, Asia Shterngas, Nir Avital, Yonatan Eran, Marcela Viviana Karpuj, Milana Frenkel-Morgenstern, Meir Shamay
Kaposi's sarcoma associated herpesvirus (KSHV, HHV-8) is a gamma herpesvirus associated with several human malignancies. DNA methylation at CpG dinucleotides is an epigenetic mark dysregulated in many cancer types, and in KSHV infected cells. Several previous studies have analyzed in detail the CpG methylation of the KSHV episomal genomes, but little is known about the impact of KSHV on the human genome. Our knowledge of cellular CpG methylation in the context of KSHV infection is currently limited to four hyper-methylated human gene promoters...
June 13, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29898894/clinical-predictors-of-successful-and-earlier-pleurodesis-with-a-tunnelled-pleural-catheter-in-malignant-pleural-effusion-a-cohort-study
#11
Pen Li, Alison Graver, Sarah Hosseini, Sunita Mulpuru, Lorraine Cake, Lynn Kachuik, Tinghua Zhang, Kayvan Amjadi
BACKGROUND: Tunnelled pleural catheters used to treat malignant pleural effusions may achieve pleurodesis. We aimed to identify factors associated with higher pleurodesis rates and earlier catheter removal. METHODS: We retrospectively reviewed a prospective database of tunnelled pleural catheters inserted consecutively between May 2006 and June 2013 for confirmed malignant pleural effusion. The cohort included patients who underwent medical thoracoscopy. Clinical, radiologic and pleural fluid data were recorded...
April 2018: CMAJ Open
https://www.readbyqxmd.com/read/29898873/effectiveness-and-safety-of-local-anesthetic-semi-flexible-pleuroscopy-experience-from-a-peripheral-hospital
#12
L V Rodrigues, G Samouco, R Gomes, C Santos, L Ferreira
If the seemingly less invasive semi-flexible pleuroscopes are combined with strategies of conscious sedation and local anesthesia the pleuroscopy has the potential to reach an increasing number of hospital settings. Local experiences can provide valuable information pertaining to the reproducibility of this technique in different scenarios. We performed a retrospective analysis of the clinical records of all patients that had undergone local anesthetic semi-flexible pleuroscopy in our unit between February 2015 and July 2017...
June 10, 2018: Pulmonology
https://www.readbyqxmd.com/read/29896675/pathological-features-of-kaposi-s-sarcoma-associated-herpesvirus-infection
#13
Harutaka Katano
Kaposi's sarcoma-associated herpesvirus (KSHV, human herpesvirus 8, or HHV-8) was firstly discovered in Kaposi's sarcoma tissue derived from patients with acquired immune deficiency syndrome. KSHV infection is associated with malignancies and certain inflammatory conditions. In addition to Kaposi's sarcoma, KSHV has been detected in primary effusion lymphoma, KSHV-associated lymphoma, and some cases of multicentric Castleman disease (MCD). Recently, KSHV inflammatory cytokine syndrome (KICS) was also defined as a KSHV-associated disease...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29896674/signal-transduction-pathways-associated-with-kshv-related-tumors
#14
Tadashi Watanabe, Atsuko Sugimoto, Kohei Hosokawa, Masahiro Fujimuro
Signal transduction pathways play a key role in the regulation of cell growth, cell differentiation, cell survival, apoptosis, and immune responses. Bacterial and viral pathogens utilize the cell signal pathways by encoding their own proteins or noncoding RNAs to serve their survival and replication in infected cells. Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is classified as a rhadinovirus in the γ-herpesvirus subfamily and was the eighth human herpesvirus to be discovered from Kaposi's sarcoma specimens...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29893303/primary-pulmonary-synovial-sarcoma-a-reappraisal
#15
REVIEW
Manoj Kumar Panigrahi, Gourahari Pradhan, Nibedita Sahoo, Pritinanda Mishra, Susama Patra, Prasanta Raghab Mohapatra
Synovial sarcoma (SS) is a malignant mesenchymal tumor with variable epithelial differentiation that affects mostly young adults and can arise at any anatomic site. Primary intrathoracic SS is very rare accounting for <0.5% of all lung tumors. Most commonly, it arises from the lung followed by pleura and mediastinum. Primary pulmonary SS (PPSS) affects both sexes equally with no preference for any hemithorax. The morphology, immunostaining properties, cytogenetic features, and management strategy of PPSS are similar to that of soft tissue SS...
April 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29883216/minimally-invasive-palliative-interventions-in-advanced-lung-cancer
#16
Christopher Mallow, Margaret Hayes, Roy Semaan, Thomas Smith, Russell Hales, Roy Brower, Lonny Yarmus
Lung cancer is the leading cause of cancer related deaths in the United States. Nearly 85% of all lung cancers are diagnosed at a late stage, with an associated five-year survival rate of 4%. Malignant central airway obstruction and malignant pleural effusions occur in upwards of 30% of these patients. Many of these patients are in need of palliative interventions for symptom control and to help improve their quality of life. Areas covered: This review covers the treatment modalities of malignant central airway obstruction and malignant pleural effusion...
June 8, 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29875590/bedside-pleuroscopy-in-the-intensive-care-unit
#17
Hean Ooi
Objectives: It is not always possible to move critically ill patients to the operating or endoscopy room for a pleuroscopy. Bedside pleuroscopy is indicated for these patients. The aim of this study was to investigate the safety and complications of bedside pleuroscopy in an Intensive Care Unit (ICU). Materials and Methods: The patients who had undergone routine examinations for pleural effusion, with no established diagnosis at the previous admission were included in this analysis...
April 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29874900/malignant-pleural-effusion-from-metastatic-prostate-cancer-a-case-report-with-unusual-cytologic-findings
#18
Jinyoung Jeon, Tae-Jung Kim, Hong Sik Park, Kyo-Young Lee
We present a case of 55-year-old man who complained of dyspnea and sputum for a month. He was an ex-smoker having a history of prostate cancer and pulmonary tuberculosis. Chest radiographs revealed small to moderate amount of bilateral pleural effusions. Pigtail catheters were inserted and drainage was performed. The pleural fluid contained malignant cells, arranged in large clusters and tightly cohesive groups. These cytologic findings could not with certainty be ascribed to prostate cancer. We performed immunocytochemical (ICH) panel studies to determine the origin of cancer metastasis...
June 7, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29873855/aquaporin-1-aqp-1-expression-in-fluoro-edenite-induced-mesothelioma-effusions-an-approach-by-cell-block-procedure
#19
Giuseppe Angelico, Antonio Ieni, Rosario Caltabiano, Pio Zeppa, Giovanni Tuccari
OBJECTIVE: Aquaporin 1 (AQP-1) is a water channel protein found in cell membranes, whose expression has been considered an independent favourable prognostic factor in pleural Malignant Mesothelioma (MM). The aim of this study is to evaluate the expression of AQP-1 and its prognostic value in a series of pleural MM effusions, from a geographic area with high concentrations of Fluoro-Edenite (FE). METHODS: We selected twenty-five MM cases from Biancavilla (Italy), an area with high environmental concentrations of FE...
June 6, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29872581/tumor-cell-released-autophagosomes-trap-enhance-apoptosis-and-immunosuppressive-functions-of-neutrophils
#20
Rong Gao, Jie Ma, Zhifa Wen, Peiying Yang, Jinjin Zhao, Meng Xue, Yongqiang Chen, Mohanad Aldarouish, Hong-Ming Hu, Xue-Jun Zhu, Ning Pan, Li-Xin Wang
Our previous studies have confirmed that tumor cell-released autophagosomes (TRAP) could induce the differentiation of B cells into IL-10+ regulatory B cells (Bregs) with suppressive activities on T lymphocytes. However, the mechanism of TRAP-mediated immune suppression is still largely unclear. Herein, we sought to assess the immunomodulatory effect of TRAPs on human neutrophils, a major immune cell type that infiltrates human tumor tissues. We found that TRAPs enriched from malignant effusions or ascites of cancer patients and tumor cell lines were rapidly and effectively phagocytized by neutrophils through macropinocytosis and promoted neutrophil apoptosis via reactive oxygen species (ROS) generation and caspase-3 activation...
2018: Oncoimmunology
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