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https://www.readbyqxmd.com/read/29204218/interpreting-the-mechanism-of-apoe-p-leu167del-mutation-in-the-incidence-of-familial-hypercholesterolemia-an-in-silico-approach
#1
REVIEW
Omran Mohammed Rashidi, Fatima Amanullah H Nazar, Mohamed Nabil Alama, Zuhier Ahmed Awan
Background: Apolipoprotein E (APOE) gene is a ligand protein in humans which mediates the metabolism of cholesterol by binding to the low-density lipoprotein receptor (LDLR). P.Leu167del mutation in APOE gene was recently connected with Familial Hypercholesterolemia, a condition associated with premature cardiovascular disease. The consequences of this mutation on the protein structure and its receptor binding capacity remain largely unknown. Objective: The current study aims to further decipher the underlying mechanism of this mutation using advanced software-based algorithms...
2017: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/29197031/preclinical-evaluation-of-the-aurora-kinase-inhibitors-amg-900-azd1152-hqpa-and-mk-5108-on-sw-872-and-93t449-human-liposarcoma-cells
#2
Sandhya Noronha, Lauren A C Alt, Taylor E Scimeca, Omran Zarou, Justyna Obrzut, Brian Zanotti, Elizabeth A Hayward, Akhil Pillai, Shubha Mathur, Joseph Rojas, Ribhi Salamah, Nalini Chandar, Michael J Fay
Liposarcoma is a malignant soft tissue tumor that originates from adipose tissue and is one of the most frequently diagnosed soft tissue sarcomas in humans. There is great interest in identifying novel chemotherapeutic options for treating liposarcoma based upon molecular alterations in the cancer cells. The Aurora kinases have been identified as promising chemotherapeutic targets based on their altered expression in many human cancers and cellular roles in mitosis and cytokinesis. In this study, we investigated the effects of an Aurora kinase A inhibitor (MK-5108), an Aurora kinase B inhibitor (AZD1152-HQPA), and a pan-Aurora kinase inhibitor (AMG 900) on undifferentiated SW-872 and well-differentiated 93T449 human liposarcoma cells...
December 1, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/29189778/probing-many-body-dynamics-on-a-51-atom-quantum-simulator
#3
Hannes Bernien, Sylvain Schwartz, Alexander Keesling, Harry Levine, Ahmed Omran, Hannes Pichler, Soonwon Choi, Alexander S Zibrov, Manuel Endres, Markus Greiner, Vladan Vuletić, Mikhail D Lukin
Controllable, coherent many-body systems can provide insights into the fundamental properties of quantum matter, enable the realization of new quantum phases and could ultimately lead to computational systems that outperform existing computers based on classical approaches. Here we demonstrate a method for creating controlled many-body quantum matter that combines deterministically prepared, reconfigurable arrays of individually trapped cold atoms with strong, coherent interactions enabled by excitation to Rydberg states...
November 29, 2017: Nature
https://www.readbyqxmd.com/read/29187950/assessment-of-methicillin-resistant-staphylococcus-aureus-detection-methods-analytical-comparative-study
#4
Omer Mohammed Ali Ibrahim, Naser Eldin Bilal, Omran Fadl Osman, Magzoub Abbas Magzoub
Introduction: The heterogeneous expression of methicillin resistance in Staphylococcus aureus (MRSA) affects the efficiency of tests available to detect it. The objective of this study was to assess four phenotypic tests used to detect MRSA. Methods: This is an analytical comparative study conducted among sudanese patients during period from May 2012 to July 2014, Staphylococcus aureus strains were isolated and identified by conventional methods, and then confirmed by PCR detection of coagulase gene...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29184614/idiopathic-fascicular-left-ventricular-tachycardia
#5
Yaser Alahmad, Nidal Ahmad Asaad, Salaheddin Omran Arafa, Shahul Hameed Ahmad Khan, Alsayed Mahmoud
Idiopathic left fascicular ventricular tachycardia (ILFVT) is characterized by right bundle branch block morphology and left axis deviation. We report a case of idiopathic left ventricular fascicular tachycardia in a young 31-year-old male patient presenting with a narrow complex tachycardia.
July 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/29184547/zinc-limitation-induces-a-hyper-adherent-goliath-phenotype-in-candida-albicans
#6
Dhara Malavia, Laura E Lehtovirta-Morley, Omran Alamir, Elisabeth Weiß, Neil A R Gow, Bernhard Hube, Duncan Wilson
Pathogenic microorganisms often face acute micronutrient limitation during infection due to the action of host-mediated nutritional immunity. The human fungal pathogen Candida albicans is polymorphic and its morphological plasticity is one of its most widely recognized pathogenicity attributes. Here we investigated the effect of zinc, iron, manganese, and copper limitation on C. albicans morphology. Restriction of zinc specifically resulted in the formation of enlarged, spherical yeasts, a phenotype which we term Goliath cells...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29177223/how-to-study-effectively
#7
Alexander Fowler, Katharine Whitehurst, Yasser Al Omran, Shivanchan Rajmohan, Yagazie Udeaja, Kiron Koshy, Buket Gundogan
The ability to study effectively is an essential part of completing a medical degree. To cope with the vast amount of information and skills needed to be acquired, it is necessary develop effective study techniques. In this article we outline the various methods students can use to excel in upcoming examinations.
July 2017: International Journal of Surgery. Oncology
https://www.readbyqxmd.com/read/29175038/renin-angiotensin-system-blockade-does-not-attenuate-abdominal-aortic-aneurysm-growth-rupture-rate-or-perioperative-mortality-after-elective-repair
#8
REVIEW
Konrad Salata, Muzammil Syed, Mohamad A Hussain, Rachel Eikelboom, Charles de Mestral, Subodh Verma, Mohammed Al-Omran
OBJECTIVE: The objective of this study was to summarize the literature regarding the effects of renin-angiotensin system blockade (RASB) using angiotensin-converting enzyme inhibitors (ACEis) or angiotensin receptor blockers (ARBs) on human abdominal aortic aneurysm (AAA) growth, rupture, and perioperative mortality. METHODS: We conducted a systematic review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Our review protocol was registered at the International Prospective Register of Systematic Reviews (CRD42016054082)...
November 23, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29172679/in-silico-approach-to-investigate-the-structural-and-functional-attributes-of-familial-hypercholesterolemia-variants-reported-in-the-saudi-population
#9
Fatima A Morad, Omran M Rashidi, Saida S Sadath, Faisal A Al-Allaf, Mohammad Athar, Mohamed N Alama, Sherif E Edris, Nabeel S Bondagji, Noor A Shaik, Babajan Banaganapalli, Zuhier Awan
Familial hypercholesterolemia (FH) is a metabolic disorder that leads primarily to premature cardiovascular diseases, the main cause of mortality in Saudi Arabia (SA). FH is underreported and underdiagnosed in SA with statistical evidence of high expected prevalence in such a consanguineous community. Lacking knowledge of which and how these alterations are actually impacting lipid metabolism is one of the main reasons why FH is insufficiently diagnosed in the region. The aim of this study was to develop a fast prediction approach using an integrated bioinformatics method for future screening of the potential causative variants from national registries...
November 27, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/29172265/snps-in-the-insulin-like-growth-factor-gene-and-obesity-impact-on-colorectal-cancer-in-egyptians
#10
Ayman Yosry, Dalia Omran, Mohamad Yousef, Mohamad Salah, Heba Omar, Sherif Hamdy, Olfat Shaker, Yahya Elsherif, Mohamad S Marie
Background and aims: The insulin pathway may play a role in development of colorectal cancer (CRC). In this study, we investigated associations between CRC and obesity in Egyptians with reference to single nucleotide polymorphisms (SNPs) in the insulin-like growth factor-1 (IGF-I) gene. We also studied serum levels of IGF-1in Egyptian CRC patients with different BMI values. Methods: This prospective study included 66 CRC patients and 30 healthy individuals, for whom body mass index (BMI) was estimated, patients and controls being categorized into overweight or obese in one group and average weight in the other...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29152822/thoracic-endovascular-repair-versus-medical-management-for-acute-uncomplicated-type-b-aortic-dissection
#11
Tariq H Enezate, Jad Omran, Ashraf S Al-Dadah, Christopher White, Mitul Patel, Ehtisham Mahmud, Rossella Fattori, Jeffrey A Goldstein, Nilesh Goswami, William A Gray, Deepak L Bhatt
BACKGROUND: Current treatment options and outcomes for acute uncomplicated thoracic Type-B aortic dissection (TBAD) remain unclear between medical management (MED) and thoracic endovascular aortic repair (TEVAR). In this study we aim to compare both strategies in terms of all-cause mortality, aortic dilation, and aortic rupture. METHODS: MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were queried from January 1990 through March 2017. Only studies comparing TEVAR to MED for acute uncomplicated TBAD were included...
November 20, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29146700/phenotypic-spectrum-of-children-with-nephronophthisis-and-related-ciliopathies
#12
Jens König, Birgitta Kranz, Sabine König, Karl Peter Schlingmann, Andrea Titieni, Burkhard Tönshoff, Sandra Habbig, Lars Pape, Karsten Häffner, Matthias Hansen, Anja Büscher, Martin Bald, Heiko Billing, Raphael Schild, Ulrike Walden, Tobias Hampel, Hagen Staude, Magdalena Riedl, Norbert Gretz, Martin Lablans, Carsten Bergmann, Friedhelm Hildebrandt, Heymut Omran, Martin Konrad
BACKGROUND AND OBJECTIVES: Genetic heterogeneity and phenotypic variability are major challenges in familial nephronophthisis and related ciliopathies. To date, mutations in 20 different genes (NPHP1 to -20) have been identified causing either isolated kidney disease or complex multiorgan disorders. In this study, we provide a comprehensive and detailed characterization of 152 children with a special focus on extrarenal organ involvement and the long-term development of ESRD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We established an online-based registry (www...
November 16, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29133602/cardiovascular-outcomes-and-safety-of-empagliflozin-in-patients-with-type-2-diabetes-mellitus-and-peripheral-artery-disease-a-subanalysis-of-empa-reg-outcome
#13
Subodh Verma, C David Mazer, Mohammed Al-Omran, Silvio E Inzucchi, David Fitchett, Uwe Hehnke, Jyothis T George, Bernard Zinman
Peripheral artery disease (PAD) is one of the most common cardiovascular complications in patients with type 2 diabetes mellitus (T2DM)(1) and is a predictor of cardiovascular death.(2) Interventions that reduce cardiovascular complications in this patient population are urgently required. In the EMPA-REG OUTCOME trial, the sodium glucose cotransporter 2 inhibitor empagliflozin reduced the risk of cardiovascular death by 38% (hazard ratio [HR], 0.62; 95% confidence interval [CI] 0.49-0.77]) and hospitalization for heart failure (HHF) by 35% (HR, 0...
November 13, 2017: Circulation
https://www.readbyqxmd.com/read/29114700/invasive-candidiasis-in-pediatric-patients-at-king-fahad-medical-city-in-central-saudi-arabia-a-5-year-retrospective-study
#14
Zainab Almooosa, Gasmelseed Y Ahmed, Abeer Omran, Ayah AlSarheed, Afnan Alturki, Abdulaziz Alaqeel, Mohammed Alshehri, Tariq Alfawaz, Dayel AlShahrani
To identify predisposing factors, species distribution, antifungal susceptibility, and outcome. Methods: This study is a retrospective chart review that was conducted at a children's hospital at King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia. One hundred twenty-nine children with invasive candidiasis who were admitted between January 2010 and January 2015. Results: The statistical analysis results have revealed a group of risk factors; prematurity in 37 (28.7%) of patients, low birth weight in 42 (32...
November 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/29089788/adalimumab-impact-on-fatigue-measured-by-facit-f-a-study-of-rheumatoid-arthritis-patients-in-saudi-arabia
#15
Nahed Janoudi, Narges Omran, Waleed Hussain, Hanan Al-Osaimi, Matouqa Baamer, Muhammad Irfanullah Siddiqui, Omar Fathaldin, Hani Almoallim
OBJECTIVE: The objective of the study was to assess the effectiveness of adalimumab as a treatment for fatigue in patients with rheumatoid arthritis (RA). METHODS: Fatigue was monitored in patients with RA who were already on an adalimumab treatment regimen. Fatigue, general well-being, comorbidities, and disease activity were measured at baseline and ~8, 16, and 24 weeks, thereafter. RESULTS: Significant reductions in fatigue scores and disease activity were observed from baseline to 6 months after...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29080085/dual-mtorc1-mtorc2-blocker-as-a-possible-therapy-for-tauopathy-in-cellular-model
#16
Mohamed Salama, Mahmoud Elhussiny, Alshimaa Magdy, Ahmed G Omran, Aziza Alsayed, Ramy Ashry, Wael Mohamed
Tauopathy comprises a group of disorders caused by abnormal aggregates of tau protein. In these disorders phosphorylated tau protein tends to accumulate inside neuronal cells (soma) instead of the normal axonal distribution of tau. A suggested therapeutic strategy for tauopathy is to induce autophagy to increase the ability to get rid of the unwanted tau aggregates. One of the key controllers of autophagy is mTOR. Blocking mTOR leads to stimulation of autophagy. Recently, unravelling molecular structure of mTOR showed that it is formed of two subunits: mTORC1/C2...
October 27, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29075979/second-generation-cryoballoon-ablation-for-persistent-atrial-fibrillation-an-updated-meta-analysis
#17
Hazem Omran, Klaus-Jürgen Gutleben, Stephan Molatta, Thomas Fischbach, Birgit Wellmann, Dieter Horstkotte, Britta Körber, Georg Nölker
BACKGROUND: Catheter ablation is an established treatment option for patients with symptomatic atrial fibrillation (AF). The cornerstone of AF ablation is pulmonary vein isolation (PVI). The second-generation cryoballoon (2G-CB) has shown non-inferiority to radiofrequency (RF) ablation in paroxysmal AF in several trials. Growing evidence suggests that 2G-CB is also effective in patients with persistent AF (perAF). The aim of this study was to summarize and analyze available data on safety and mid-term (≥ 12 months) efficacy of PVI using 2G-CB in patients with perAF...
October 26, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29071158/lingual-mucosal-graft-two-stage-bracka-technique-for-redo-hypospadias-repair
#18
Ahmed Sakr, Ehab Elkady, Mohamed Abdalla, Amr Fawzi, Mostafa Kamel, Esam Desoky, Mohamed Seleem, Mohamed Omran, Ehab Elsayed, Salem Khalil
OBJECTIVES: To report our initial experience in redo hypospadias repair with a lingual mucosal graft (LMG) using a two-stage Bracka technique. PATIENTS AND METHODS: This study was prospectively conducted and included 26 patients with hypospadias with failed previous repairs. All the patients had a LMG using a two-stage Bracka technique. In the first stage, the harvested LMG, from the ventro-lateral surface of the tongue, was implanted in a well-prepared vascularised bed in the ventral aspect of the penis...
September 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29071151/silodosin-in-the-treatment-of-distal-ureteric-stones-in-children-a-prospective-randomised-placebo-controlled-study
#19
Hazem Elgalaly, Ahmed Eliwa, Mohamed Seleem, Emad Salem, Mohammed Omran, Haitham Shello, Khalid Abdelwahab, Salem Khalil, Mostafa Kamel
OBJECTIVES: To evaluate the possible role of silodosin (a highly selective α1A-adrenoceptor antagonist) in facilitating the passage of distal ureteric stones (DUS) in children, as the role of α-blockers as medical expulsive therapy is well known in adults. PATIENTS AND METHODS: In all, 40 paediatric patients (27 boys and 13 girls) diagnosed with unilateral, single, radiopaque DUS of <10 mm were included in the study. Their mean (SD, range) age was 8.1 (2.7, 5-17) years...
September 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29064851/de-novo-versus-recurrent-hepatocellular-carcinoma-following-direct-acting-antiviral-therapy-for-hepatitis-c-virus
#20
Ashraf O Abdelaziz, Mohamed M Nabil, Ahmed H Abdelmaksoud, Hend I Shousha, Ahmed A Cordie, Eman M Hassan, Dalia A Omran, Rania Leithy, Tamer M Elbaz
INTRODUCTION: A recent appearance of direct-acting antivirals (DAAs) led to a surge in hepatitis C virus (HCV) management. Nowadays, a large proportion of treated patients have cirrhosis with a retained possibility to develop hepatocellular carcinoma (HCC) even after complete cure. We aimed to study tumoral differences between patients who developed HCC after DAAs as either a recurrence or de-novo HCC. METHODS: We retrospectively analyzed 89 patients who presented to our HCC multidisciplinary clinic with HCC lesions following DAA therapy...
October 23, 2017: European Journal of Gastroenterology & Hepatology
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