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https://www.readbyqxmd.com/read/28641826/the-chemical-history-of-morphine-an-8000-year-journey-from-resin-to-de-novo-synthesis
#1
Karolina Brook, Jessica Bennett, Sukumar P Desai
Evidence of human use of opium dates back as far as the sixth millennium BCE. Ancient societies through the Renaissance period created a variety of opium products, proliferating its common use and subsequent addiction. Because the active moiety was not known at this time, the potency of these opium concoctions could neither be predicted nor controlled. The first step in identifying opium's active ingredient, morphine, was its chemical isolation in the early 1800s by Wilhelm Sertürner. The subsequent elucidation of morphine's chemical formula and Sir Robert Robinson's derivation of morphine's structural formula, which won him the 1947 Nobel Prize in Chemistry, round out 150 years of the incremental advances in our chemical understanding of morphine...
April 2017: Journal of Anesthesia History
https://www.readbyqxmd.com/read/28641824/a-newly-discovered-manuscript-of-charles-t-jackson-md-history-of-the-patenting-of-the-application-of-sulphuric-ether-for-the-production-of-insensibility
#2
Rajesh P Haridas, George S Bause
In 2016, the Wood Library-Museum of Anesthesiology, Schaumburg, IL, acquired an unpublished 11-page manuscript written by Charles Thomas Jackson, MD, (1805-1880). The undated manuscript, now fully transcribed, provides Jackson's perspective of the first 6 weeks of the ether discovery, from early October 1846 to mid-November 1846. It chronicles Jackson's observations and discussions pertaining to United States Patent No. 4848, granted to him and William Thomas Green Morton, MD, (1819-1868). Jackson's manuscript did not yield new information on the discovery of surgical etherization or the subsequent dispute between him and Morton...
April 2017: Journal of Anesthesia History
https://www.readbyqxmd.com/read/28639076/conservative-treatment-for-lumbar-compartment-syndrome-shows-efficacy-over-2-year-follow-up-a-case-report-and-literature-review
#3
Haruhisa Kanaya, Makoto Enokida, Shinji Tanishima, Ikuta Hayashi, Atsushi Tanida, Hideki Nagashima
BACKGROUND: Since in all studies of conservative treatment of lumbar compartment syndrome the follow-up duration was less than 6 months, it is difficult to draw firm conclusions. PURPOSE: To report a patient with lumbar paraspinal compartment syndrome who was treated conservatively over a follow-up period of 2 years. STUDY DESIGN: This is a case report of a 23-year-old male college student with lumbar paraspinal compartment syndrome who was treated conservatively...
June 20, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28637375/anticoagulant-therapy-for-recurrent-in-stent-thrombosis-following-carotid-artery-stenting-a-case-report
#4
Akinori Miyakoshi, Hiroki Toda, Makoto Hayase, Takeshi Kawauchi, Yuki Oichi, Etsuko Hattori
We report a case in which strict anticoagulant therapy management was useful for a recurrent in-stent thrombosis after carotid artery stenting (CAS). An 84-year-old man presented with cognitive decline that progressed rapidly over two months. Head magnetic resonance imaging showed an acute-stage infarct occurring frequently in the right cerebral hemisphere, and he underwent hospitalization and treatment. On neck magnetic resonance angiography (MRA), severe stenosis was found at the origin of the right internal carotid artery...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28637076/-clinical-course-of-an-early-childhood-onset-granulomatosis-with-polyangiitis
#5
Marco Krasselt, Matthias Pierer, Kerstin Amann, Anette Bachmann, Tom H Lindner
History A 26-year-old male patient presented with an eight-week history of unspecific symptoms such as weight loss and fever. Besides, he also suffered from haemoptysis, cough, and arthralgia. Since the age of twelve years, the patient has been treated for Wegner's granulomatosis. At the age of 20 years he received a kidney transplant which failed only four years later. Investigations The relapse we clinically suspected was confirmed by CT scan showing bilateral pulmonary manifestations. Moreover, we found highly positive antibodies against proteinase 3...
June 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28635104/response-to-letter-to-the-editor-persistent-neuropsychiatric-impairment-in-hcv-patients-or-educational-mismatch
#6
Meike Dirks, Henning Pflugrad, Karin Weissenborn
First, we would like to thank Dr. Gade for his interest in our study. Obviously Dr. Gade wonders if our findings in HCV patients are an artifact due to systematic bias based on a neglect of the study subjects' education. In his opinion "patients with HCV have almost invariably been more poorly educated than comparison groups". We can assure him that his statement does not fit in respect to our study group as most of the patients were infected via blood transfusion or application of blood products. HCV infection is not inevitably associated with poor education (see table 1)...
June 21, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28632524/callosal-motor-impersistence-a-novel-disconnection-syndrome
#7
Hee Jin Kim, Dongyeop Kim, Da-Heen Won, Juhee Chin, Kwang Ho Lee, Sang Won Seo, Kenneth M Heilman, Duk L Na
Motor impersistence, an inability to sustain a certain position or movement, is a motor-intentional disorder, caused more often by right than left hemisphere lesions. Since the right hemisphere is dominant for mediating motor persistence, callosal lesions that disconnect the left hemisphere from the right may induce impersistence of the right upper and lower limbs. After an undiagnosed left callosal infarction, a 65-year-old right-handed man suddenly developed a transient loss of volitional movement of his left leg...
June 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28632523/frontotemporal-dementia-presenting-as-gambling-disorder-when-a-psychiatric-condition-is-the-clue-to-a-neurodegenerative-disease
#8
Giacomo Tondo, Fabiola De Marchi, Emanuela Terazzi, Marta Sacchetti, Roberto Cantello
Behavioral variant frontotemporal dementia, the most common form of frontotemporal dementia, is characterized by executive dysfunction and changes in personality and behavior, sometimes with associated psychiatric disorders. We report a man who suddenly developed a gambling disorder when he was 55 years old. A year later he developed personality changes of agitation, euphoria, and disinhibition, along with binge eating and dysthymia. He did not improve on paroxetine 40 mg/day. Two years after the onset of his symptoms, he came to our clinic for evaluation...
June 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28625939/promoting-the-maintenance-of-satisfactory-communication-strategies-used-by-caregivers-and-medical-staff-with-people-suffering-from-alzheimer-s-disease
#9
Marie Vachon, Marie-Christine Veilleux, Joël Macoir
The goal of this literature review was to determine communication strategies that foster interactions between individuals with Alzheimer's disease (AD) and caregivers or medical staff. A search of PubMed and PsycINFO databases was conducted using combinations of the following terms: Alzheimer, family, caregiver, communication, language, treatment, intervention, therapy, communication strategies, functional communication and daily living activities. Studies were chosen based on the original language of the text, year of publication, peer-review status and specificity of the results regarding communication strategies in AD...
June 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28625145/clomiphene-for-the-treatment-of-male-infertility-a-case-report-of-mood-change
#10
Marine Aussedat, Jennifer Jean-Louis, Orchidée Djahangirian, Marie-Sophie Brochet
BACKGROUND: Clomiphene is normally used in women with ovulatory dysfunction. In men, it is used off label in some cases of infertility. Psychological adverse effects are reported in women but very few in men. CASE: A 34 year-old man treated with clomiphene for oligoteratospermia presented anxiety, decreased appetite, and depressed mood making him unable to function properly at work, five days after initiation of therapy. Symptoms required reduction followed by discontinuation of treatment four days later because of absence of improvement...
June 15, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28619090/truffle-renaissance-in-poland-history-present-and-prospects
#11
REVIEW
Aleksandra Rosa-Gruszecka, Dorota Hilszczańska, Wojciech Gil, Bogusław Kosel
The use of truffles in Poland has a long tradition, yet due to some historical aspects, this knowledge was lost. Currently, truffles and truffle orchards are again receiving attention, and thanks to, e.g., historical data, they have solid foundations to be established. Publications relating to truffles between 1661 and 2017 were searched for in international and national databases, such as the database of PhD theses, Google Scholar, and catalogues of the National Library of Poland, the Jagiellonian Digital Library, the University Library of J...
June 15, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28612891/the-tragic-tale-of-a-father-and-son-an-unusual-patricide
#12
G Di Vella, I Grattagliano, M C Romanelli, J B Duval, R Catanesi
Parricide is a category of homicide in which the victims are the parents, and the killers, their children. The authors report a case of a 45-year-old man who killed his 73-year-old widowed father in an extremely violent manner: he struck the father in the head with a wooden wash board, stabbed him with a pair of scissors and several times with a screwdriver. Afterwards, he kicked the victim in the face and jumped up and down on his body, thereby crushing the father's chest with his weight. The case reported here may be classified as an "unusual patricide" when one considers the age of the aggressor, the diagnosis of psychiatric disorders, that the victim was the father, and that the murder was committed in an extremely violent manner...
May 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28611061/clinical-events-and-echocardiographic-lesion-progression-rate-in-subjects-with-mild-or-moderate-aortic-regurgitation
#13
Sveeta Badiani, Jet van Zalen, Saad Saheecha, Lesley Hart, Ann Topham, Nikhil Patel, Lydia Sturridge, Andrew Marshall, Neil Sulke, Stephen Furniss, Guy Lloyd
A 69 year old male, an ex-smoker, was admitted with ongoing chest pain of 11 hours duration. Past medical history included treated hypertension and gastro-oesophageal reflux disease. He delayed seeking medical attention as he assumed the pain to be due to indigestion and kept taking antacids without much symptomatic relief. Clinical examination on arrival was unremarkable. Admission 12 lead electrocardiogram (ECG) was diagnostic of a recent anterolateral myocardial infarction (MI) (Figure 1a). Bedside trans-thoracic echocardiogram (TTE) confirmed an established anterolateral MI (Video 1, Figure 1b)...
June 13, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28609863/the-synonymy-of-the-genus-permixtimella-gu%C3%A5-u-2016-crustacea-tanaidacea-with-ektraleptochelia-bamber-marshall-2015-and-remarks-on-other-leptocheliid-taxa
#14
Modest Guțu, Graham J Bird
Guţu (2016) described a new subfamily, seven new genera and 21 new species in the family Leptocheliidae. However, another five genera and twelve new species, not mentioned by him, were described in 2015 and 2016. Study of the overlooked genera reveals that the morphology of the female of Permixtimella (genus described from both sexes) is similar to those of the type-female of the genus Ektraleptochelia (whose male is unknown). Permixtimella is considered a junior synonym of Ektraleptochelia, which includes two species: E...
May 10, 2017: Zootaxa
https://www.readbyqxmd.com/read/28608944/family-centred-care-right-from-birth-the-irreplaceable-birthday-cuddle
#15
Paul Clarke
Jack, twin 2, was born vaginally at 23+1 weeks' gestation, 576 g. In good condition, despite no antenatal steroids, he was intubated and given surfactant at 3 minutes. After initial stabilisation, the resuscitaire was switched to the portable oxygen cylinder and moved alongside his mother's bed. Jack was then transferred into his mother's arms, still connected to the resuscitaire ventilator system. She was then able to cuddle him for 10-15 minutes while still being ventilated by the attendant neonatologist (Figure 1)...
June 13, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28604282/peripheral-artery-stent-dehiscence-percutaneous-management
#16
Satish Karur, Ravindranath K Shankarappa, Manjunath C Nanjappa
An elderly male presented with left abdominal swelling of 1-week duration and inability to move the left lower limb. He had undergone bilateral common iliac and left external iliac artery stenting with self-expandable stents for aortoiliac occlusive disease 1 month back. Clinical examination revealed tender abdominal nonpulsatile mass with systolic bruit. Ultrasonography suggested retroperitoneal hematoma. His hemoglobin was 7 g%. Echocardiogram showed ejection fraction of 40%. Computed tomography angiogram revealed large 10 × 10 retroperitoneal hematoma with possibility of continued bleeding from the left external iliac artery...
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28603616/to-know-mark-was-to-love-him
#17
Philippa Hill
No abstract text is available yet for this article.
April 2017: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/28602565/diverse-patient-perspectives-on-respect-in-healthcare-a-qualitative-study
#18
Mary Catherine Beach, Emily Branyon, Somnath Saha
BACKGROUND: The dominant view of respect in western bioethics focuses almost exclusively on respect for autonomy (or 'self-rule') as conceptualized primarily from the perspective of philosophers. We designed this study to understand, from the perspective of patients from different racial/ethnic groups, what it means for patients to be treated with respect in healthcare settings. METHODS: We conducted focus groups with African American, Latino, and white patients in the Northwestern U...
May 5, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28598053/healer-on-death-bed-how-and-why-revive-him-please
#19
Satish V Khadilkar
No abstract text is available yet for this article.
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28595826/-what-happens-behind-the-curtains-an-exploration-of-icu-nurses-experiences-of-post-mortem-care-on-patients-who-have-died-in-intensive-care
#20
Carien de Swardt, Nicola Fouché
THE AIM OF THE STUDY: The aim of this study was to explore the experiences of intensive care nurses performing post mortem care on patients who had died in an intensive care unit at a private hospital in Cape Town. The study further sets out to identify educational needs and to offer recommendations that may address these needs for this sample of nurses. METHODOLOGY AND SETTING: A qualitative research design using a descriptive method was used to explore the experiences of a purposive heterogeneous sample of six nurses who were working in an intensive care unit in a private hospital in Cape Town...
June 5, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
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