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https://www.readbyqxmd.com/read/28719106/altered-pulmonary-gas-transfer-capacity-and-capillary-blood-volume-in-pediatric-crohn-s-disease
#1
Marie Verstraete, Marie-Luce Choukroun, Valerie Siao-Him Fa, Michael Fayon, Laurent Rebouissoux, Raphael Enaud, Thierry Lamireau
OBJECTIVES: To describe diffusing capacity for carbon monoxide (DLCO) and its components, that is, membrane diffusing capacity (DmCO) and pulmonary capillary blood volume (Vc) in children with Crohn's disease (CD), and to investigate the correlation between these parameters and disease activity. WORKING HYPOTHESIS: The most common lung function abnormalities are a reduced pulmonary DLCO and small airways disorders which are in many instances, clinically silent. No valid explanations have been proposed regarding the modifications in gas transfer capacity in active CD...
August 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28715308/sniffing-for-cancer-nano-noses-hold-promise-for-detecting-lung-cancer-and-other-diseases
#2
Shannon Fischer
Nearly two decades ago, Hossam Haick was working on a Ph.D. degree in chemical engineering at the Technion Israel Institute of Technology when terrible news hit: his friend and officemate had leukemia. It was Haick's first close encounter with cancer and the physical toll its treatment could wreak on a person. "He's fine now, but it was very difficult to see him suffer," Haick remembers.
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28715305/the-quantified-patient-checks-in-larry-smarr-s-experiments-in-self-tracking-for-health
#3
Sarah Campbell
Like eight-year-olds who can't let go of a good joke, Larry Smarr's nurses and doctors kept coming to him with the same question: "Have you passed gas yet?" Answering this question in the aff irmative is, Smarr explains, deadpan, "the state of the art in 2017 in the medical community for deciding when your colon restarts."
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28714703/localizationism-antilocalizationism-and-the-emergence-of-the-unitary-construct-of-consciousness-in-luigi-luciani-1840-1919
#4
Giorgia Morgese, Giovanni Pietro Lombardo, Vilfredo De Pascalis
This article aims to present the construct of unitary consciousness as it emerged in the work of the Italian physiologist Luigi Luciani (1840-1919). We highlight how Luciani's work, conducted during the late 19th and early 20th centuries, integrated experimental research with the clinical observation of patients, enabling him to develop elaborate theoretical conceptions. From our historical analysis of Luciani's main works, an innovative model of unitary consciousness emerges with respect to his contemporary context...
July 17, 2017: History of Psychology
https://www.readbyqxmd.com/read/28713149/reframing-medical-appropriateness-a-case-study-concerning-the-use-of-life-sustaining-technologies-for-a-patient-with-profoundly-diminished-quality-of-life
#5
Colleen M Gallagher, Elijah Weber, Nisha Rathi
This case study considers the clinical ethics issues of medical appropriateness and quality of life for patients who are critically ill. The case involves a terminally ill cancer patient with a profoundly diminished quality of life and an extremely poor prognosis; his spouse desires to bring him home, where she will arrange to keep him alive for as long as possible via life-sustaining interventions. The analysis engages with the complicated notion of medical appropriateness, both in general and as it pertains to life-sustaining interventions in a critical care setting, and considers the ethical implications of the various ways in which one might understand this concept...
2017: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/28710885/lothar-jaenicke-and-c1-metabolism-his-first-25-years-of-research
#6
Rudolf K Thauer
The biochemist Lothar Jaenicke died on 29 December 2015, aged 92 years old. The last time I saw him was at his 90th birthday on 14 September 2013, at the occasion of which his colleagues at the Universität zu Köln (Cologne) in Germany had organized a symposium to honor him.
July 26, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/28710655/about-the-right-to-be-ill
#7
Jacek Halasz
The article raises the issue of 'the right to be ill', formulated by Tadeusz Kielanowski, a Polish physician and humanist. According to him, the right to health should be supplemented by the principle which would serve the protection of people with diseases or disabilities. One-sided interpretation of 'the right to health' may result in various forms of intolerance and discrimination. This paper presents what dangers Kielanowski recognized and explains why his approach was considered to be a novelty; what the idea of 'the right to be ill' is, how the need for it is substantiated...
July 14, 2017: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/28708986/listener-estimates-of-talker-age-in-a-single-talker-50-year-longitudinal-sample
#8
Eric J Hunter, Sarah Hargus Ferguson
PURPOSE: While many studies have shown that listeners make relatively accurate age judgments from hearing talkers' voices, most have used just one age per talker. The present study evaluated listeners' age estimation abilities for a longitudinal sample: a single talker recorded over nearly five decades. METHOD: We extracted 60 samples from addresses given by a male talker over 48 years. For each sample, listeners gave a direct estimate of his age. We also asked listeners if they could identify the talker, who was known locally, from the recordings...
June 9, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/28708973/concordance-of-beta-papillomavirus-across-anogenital-and-oral-anatomic-sites-of-men-the-him-study
#9
Emily M Nunes, Rossana V M López, Staci L Sudenga, Tarik Gheit, Massimo Tommasino, Maria L Baggio, Silvaneide Ferreira, Lenice Galan, Roberto C Silva, Eduardo Lazcano-Ponce, Anna R Giuliano, Luisa L Villa, Laura Sichero
We evaluated the concordance between β-HPVs detected in external genital skin, anal canal, and oral cavity specimens collected simultaneously from 717 men that were participating in the multinational HIM Study. Viral genotyping was performed using the Luminex technology. Species- and type-specific concordance was measured using kappa statistics for agreement. Overall, concordance of β-HPVs across sites was low and mainly observed among paired genital/anal canal samples. When grouped by species, solely β-4 HPVs showed moderate concordance in genital/anal pairs (κ = 0...
July 11, 2017: Virology
https://www.readbyqxmd.com/read/28705567/%C3%A2-%C3%A2-le-service-de-p%C3%A3-diatrie-%C3%A3-tait-notre-deuxi%C3%A3-me-maison%C3%A2-%C3%A2
#10
Emmanuelle Barsky
"THE PAEDIATRICS DEPARTMENT WAS OUR SECOND HOME".: At the age of a few months, Yakub was diagnosed with congenital liver fibrosis then polycystic kidney disease. He has been monitored regularly since then, and has had to be readmitted on several occasions due to complications. Now, aged 15, he is waiting for a liver transplant and is under the care of the adult hepatology department. The transition from paediatrics to the adult services was prepared, in advance, with him and his family. Yakub and his mother's account...
July 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28704623/process-of-change-in-pain-related-fear-clinical-insights-from-a-single-case-of-persistent-back-pain-managed-with-cognitive-functional-therapy
#11
J P Caneiro, Anne Smith, Martin Rabey, G Lorimer Moseley, Peter O'Sullivan
Study Design Single-case report with repeated measures over 18 months. Background Management of persistent low back pain (PLBP) associated with high pain-related fear is complex. This single-case report aims to provide clinicians with an insight to the process of change in a person with PLBP and high bending-related fear, managed with an individualized behavioral approach - Cognitive Functional Therapy (CFT). Case Description A retired manual worker with PLBP believed that his spine was degenerating, that bending would hurt him and avoidance was the only form of pain control...
July 13, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28702159/hodgkin-s-lymphoma-in-a-man-with-dilated-cardiomyopathy-and-paraneoplastic-ataxia-a-therapeutical-challenge
#12
Elisabetta Abruzzese, Malgorzata Monika Trawinska, Achille Gaspardone, Antonino Morocutti, Paolo de Fabritiis
Hodgkin's lymphoma is a cancer of the lymphatic system. We report the case of a man with Hodgkin's lymphoma and cardiomyopathy, for which the dilemma was whether to use the standard protocol - putting the patient at risk of worsening of heart failure, but giving him a good chance of full recovery - or not. The standard protocol was given and the patient made a full recovery without cardiac complications.
June 1, 2017: Hematology Reports
https://www.readbyqxmd.com/read/28701647/the-case-of-a-14-year-old-boy-who-experienced-anaphylaxis-due-to-jellyfish-mastigias-papua-ingestion
#13
Shohei Kubota, Asako Nozawa, Takanori Yanai, Koji Ozasa, Satomi Mori, Kazuyuki Kurihara
We report a case of jellyfish allergy diagnosed via an oral food challenge. A 14-year-old boy had no history of jellyfish stings and had been eating commercially available jellyfish products twice yearly for the past 5-6 years. Five minutes after eating a commercially available boiled jellyfish product (100g), he experienced nausea, wheezing, and erythema and had visited our hospital. We suspected an anaphylactic reaction and treated him with intramuscular adrenaline injection, corticosteroid and antihistamine infusions, volume resuscitation, and salbutamol sulfate inhalation, which resulted in an improvement of the symptoms...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/28697681/a-particularly-complex-case-of-matricide-by-means-of-plastic-bag-suffocation-case-report
#14
Arnaldo Stanislao Migliorini, Michele Boracchi, Guendalina Gentile, Francesca Maciocco, Andrea Piccinini, Riccardo Zoja
A rare case of homicide with plastic bag suffocation is presented in which forensic genetic investigations were carried out on the inner surface of a plastic bag placed over the head of an elderly woman, bedridden after a stroke. The results obtained suggested that she had been murdered and hinted at the perpetrator of the crime. In fact, it emerged that biological traces left by the victim matched those of her principal caregiver, her psychotic daughter, who later confessed to the crime. The old woman also had a son affected by a serious illness, whose genetic profile was found on the same bag...
January 1, 2017: Medicine, Science, and the Law
https://www.readbyqxmd.com/read/28695380/macular-capillary-recovery-in-systemic-lupus-erythematosus-complicated-by-kikuchi-fujimoto-disease
#15
Reiko Kinouchi, Motoshi Kinouchi, Akihiro Ishibazawa, Akitoshi Yoshida
PURPOSE: Few case reports have described vaso-occlusive retinopathy in systemic lupus erythematosus (SLE) using optical coherence tomography (OCT) angiography. Here we report the clinical features of a patient with SLE, complicated by Kikuchi-Fujimoto disease, who developed vaso-occlusive retinopathy. We then describe the subsequent recovery of the macular capillaries as assessed by OCT angiography. CASE: A 16-year-old male was referred to us with fever, a 1-month history of violaceous red papules and erythematous plaques on his face and a painful nodule in his right neck...
July 10, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28693445/older-persons-existential-loneliness-as-interpreted-by-their-significant-others-an-interview-study
#16
Helena Larsson, Margareta Rämgård, Ingrid Bolmsjö
BACKGROUND: In order to better understand people in demanding medical situations, an awareness of existential concerns is important. Studies performed over the last twenty years conclude that when dying and death come closer, as in the case with older people who are stricken by infirmity and diseases, existential concerns will come to the fore. However, studies concerning experiences of existential loneliness (EL) are sparse and, in addition, there is no clear definition of EL. EL is described as a complex phenomenon and referred to as a condition of life, an experience, and a process of inner growth...
July 10, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28690745/closed-reduction-of-a-traumatic-hip-dislocation-in-children-case-report
#17
Achraf El Bakkaly, Fouad Ettayebi, Houda Oubeja, Mounir Erraji, Hicham Zerhouni
Traumatic dislocation of the hip in children is a rare disease. It only represents 5% of hip dislocations in all age groups. Before 10 years, the mechanism is often a minimal domestic accident; after 10 years, the dislocation occurs with the waning of an accident of the public highway. It is different from that of the adult by its rarity, its ease of reduction and better prognosis. This is an emergency trauma: risk necrosis of the femoral head (If delayed reduction). We report a rare case of a 3 year old boy, who suffered from bipolar trauma after a fall near his height of his house causing him a detachment of the right humerus and post-traumatic dislocation of the left hip...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28690727/-clinical-and-immunological-profile-of-15-moroccan-patients-with-hyper-igm-syndrome
#18
Hind Ouair, Ibtihal Benhsaien, Leila Jeddane, Jalila El Bakkouri, Naima Elhafidi, Noureddine Rada, Jilali Najib, Fatima Ailal, Hanane Salih Alj, Ahmed Aziz Bousfiha
Hyper IgM syndrome is a well known genetic (primary) immunodeficiency disorder which was first described in 1961. It is caused by B lymphocyte deficiency characterized by normal or elevated serum IgM levels and low or zero levels of IgG, IgA, IgE resulting from isotype-switching deficiency. Clinical manifestations are dominated by recurrent infections, especially involving the digestive tube of the ENT sphere and the lungs. This syndrome is caused by B-cell immunoglobulin class switch deficiency and decreased capacity to induce proliferation of T lymphocytes...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28689454/identification-and-characterization-of-human-udp-glucuronosyltransferases-responsible-for-xanthotoxol-glucuronidation
#19
Guiyuan He, Johanna Troberg, Xia Lv, Yang-Liu Xia, Liang-Liang Zhu, Jing Ning, Guang-Bo Ge, Moshe Finel, Ling Yang
1. Xanthotoxol is a furanocoumarin that possesses many pharmacological activities and in this study its in vitro glucuronidation was studied. 2. Xanthotoxol can be rapidly metabolized to a mono-glucuronide in both human intestine microsomes (HIM) and human liver microsomes (HLM); the structure of the metabolite was confirmed by NMR spectroscopy. 3. Reaction phenotyping with 12 commercial recombinant human UGTs, as well as with the Helsinki laboratory UGT1A10 that carry a C-terminal His-tag (UGT1A10-H), revealed that UGT1A10-H catalyzes xanthotoxol glucuronidation at the highest rate, followed by UGT1A8...
July 10, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28688672/an-examination-of-pre-and-posttreatment-acoustic-versus-auditory-perceptual-analyses-of-voice-across-four-common-voice-disorders
#20
Amanda I Gillespie, Jackie Gartner-Schmidt, Ali Lewandowski, Shaheen N Awan
OBJECTIVE: The objective, instrumental acoustic measure of Cepstral Spectral Index of Dysphonia (CSID) correlates with audio-perceptual measures, is sensitive in detecting voice abnormalities, and tracks change following treatment. The goals of the current study were to (1) test the agreement between CSID versus auditory perceptual measures of pre- versus posttreatment voice change, and (2) investigate whether change in scores is based on voice disorder or phonemic structure of sentence stimuli...
July 5, 2017: Journal of Voice: Official Journal of the Voice Foundation
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