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Plasmacytoid dendritic cells cancer

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https://www.readbyqxmd.com/read/29763678/acute-aerobic-exercise-induces-a-preferential-mobilisation-of-plasmacytoid-dendritic-cells-into-the-peripheral-blood-in-man
#1
Frankie F Brown, John P Campbell, Alex J Wadley, James P Fisher, Sarah Aldred, James E Turner
Dendritic cells (DCs) are important sentinel cells of the immune system responsible for presenting antigen to T cells. Exercise is known to cause an acute and transient increase in the frequency of DCs in the bloodstream in humans, yet there are contradictory findings in the literature regarding the phenotypic composition of DCs mobilised during exercise, which may have implications for immune regulation and health. Accordingly, we sought to investigate the composition of DC sub-populations mobilised in response to acute aerobic exercise...
May 12, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29753693/oral-administration-of-5-aminolevulinic-acid-induces-heme-oxygenase-1-expression-in-peripheral-blood-mononuclear-cells-of-healthy-human-subjects-in-combination-with-ferrous-iron
#2
Hidenori Ito, Yoshiaki Nishio, Takeshi Hara, Hidemitsu Sugihara, Tohru Tanaka, Xiao-Kang Li
Heme oxygenase-1 (HO-1) is a major anti-inflammatory enzyme and a key regulator that induces immune tolerance through affecting the differentiation of dendritic cells. The aim of this study is to determine whether the combination of 5-aminolevulinic acid (ALA) and iron induces HO-1 expression in healthy human peripheral blood mononuclear cells (PBMC). The study was an open labeled, non-randomized, non-placebo-controlled trial using healthy male adults and consisted of three parts. Study A aimed to find the peak HO-1 expression at 0, 1, 2, 3, 4, 6, 8, 12, 16, and 24h after administration...
May 10, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29705980/blastic-plasmacytoid-dendritic-cell-neoplasm-arising-from-clonal-hematopoiesis
#3
Sakurako Suma, Mamiko Sakata-Yanagimoto, Tran B Nguyen, Keiichiro Hattori, Taiki Sato, Masayuki Noguchi, Yasuhito Nannya, Seishi Ogawa, Rei Watanabe, Manabu Fujimoto, Naoya Nakamura, Manabu Kusakabe, Hidekazu Nishikii, Takayasu Kato, Shigeru Chiba
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare subtype of myeloid neoplasm. Clonal evolution in the development of BPDCN remains to be elucidated. In the present study, we examined clonal evolution in a case of BPDCN by analyzing the distribution of gene mutations in tumor cells and non-tumor blood cells. The p.D1129fs and p.K1005fs TET2 mutations, p.P95H SRSF2 mutation, and p.L287fs NPM1 mutation were identified in a skin tumor at diagnosis and peripheral blood mononuclear cells at relapse...
April 28, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29588348/intratumoral-cpg-b-promotes-anti-tumoral-neutrophil-cdc-and-t-cell-cooperation-without-reprograming-tolerogenic-pdc
#4
Marion Humbert, Leslie Guery, Dale Brighouse, Sylvain Lemeille, Stephanie Hugues
Cancer immunotherapies utilize distinct mechanisms to harness the power of the immune system to eradicate cancer cells. Therapeutic vaccines, aimed at inducing active immune responses against an existing cancer, are highly dependent on the immunological microenvironment, where many immune cell types display high levels of plasticity and, depending on the context, promote very different immunological outcomes. Among them, plasmacytoid dendritic cells (pDC), known to be highly immunogenic upon inflammation, are maintained in a tolerogenic state by the tumor microenvironment...
March 27, 2018: Cancer Research
https://www.readbyqxmd.com/read/29568358/systemic-administration-of-a-tlr7-agonist-attenuates-regulatory-t-cells-by-dendritic-cell-modification-and-overcomes-resistance-to-pd-l1-blockade-therapy
#5
Naoto Nishii, Hidetake Tachinami, Yuta Kondo, Yulong Xia, Yoshihisa Kashima, Tatsukuni Ohno, Shigenori Nagai, Lixin Li, Walter Lau, Hiroyuki Harada, Miyuki Azuma
Research on immune checkpoint blockade therapy has made great progress in cancer immunotherapy, but the number of patients who benefit from this therapy remains limited. In this study, we examined the effects of monotherapy with systemic low-dose resiquimod, a synthesized TLR7 agonist, and examined its combined effects with PD-L1 blockade in two PD-L1 blockade-resistant tumor models (SCCVII and Colon 26). Resiquimod monotherapy in SCCVII tumors, representing impaired CD8+ T cell function and accelerated regulatory T cells (Tregs) within the tumors, efficiently reduced tumor growth with more recruitment of CD8+ T cells and a reduction of Treg...
March 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29553870/improved-in-vitro-and-in-vivo-activity-against-cd303-expressing-targets-of-the-chimeric-122a2-antibody-selected-for-specific-glycosylation-pattern
#6
Nathalie Fournier, Emilie Jacque, Alexandre Fontayne, Delphine Derache, Gilles Dupont, Lucie Verhaeghe, Linda Baptista, Aurélie Dehenne, Anne-Sophie Dezetter, Aurélie Terrier, Alain Longue, Virginie Pochet-Beghin, Cecile Beghin, Sami Chtourou, Christophe de Romeuf
Plasmacytoid dendritic cells (pDCs) play a central role for both innate and adaptive antiviral responses, as they direct immune responses through their unique ability to produce substantial concentrations of type I interferon (IFNs) upon viral encounter while also activating multiple immune cells, including macrophages, DCs, B, natural killer and T cells. Recent evidence clearly indicates that pDCs also play a crucial role in some cancers and several auto-immune diseases. Although treatments are currently available to patients with such pathologies, many are not fully efficient...
March 19, 2018: MAbs
https://www.readbyqxmd.com/read/29552142/gastric-cancer-patients-have-elevated-plasmacytoid-and-cd1c-dendritic-cells-in-the-peripheral-blood
#7
Weihuang Liu, Jie Zhao, Qiaoqi Li, Qiaona Wang, Ying Zhou, Zan Tong
Dendritic cells (DCs) are important in tumor immunology. Identifying DC subset markers in the peripheral blood, which are informative for gastric cancer stages, is not only useful for prognosis but may also provide mechanistic insights into processes facilitating therapy. The present study investigated plasmacytoid dendritic cells (pDCs) and myeloid CD1c+ dendritic cells (mDC1s) in the peripheral blood of patients with gastric cancer and healthy controls using flow cytometry. Using peripheral DC staining and subset analysis, patients with gastric cancer were identified to have substantially higher numbers of peripheral pDCs and mDC1s...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29456743/il-10-in-the-microenvironment-of-hnscc-inhibits-the-cpg-odn-induced-ifn-%C3%AE-secretion-of-pdcs
#8
Karl-Ludwig Bruchhage, Sabrina Heinrichs, Barbara Wollenberg, Ralph Pries
It has been shown that head and neck squamous cell carcinoma (HNSCC) are infiltrated by plasmacytoid dendritic cells (pDCs). The HNSCC TH2 biased microenvironment leads to strong alterations of the cellular functions of pDC and thus impairs the initiation and function of adequate immune responses. In this work we comprehensively analyzed the capacity of CpG-oligonucleotides to activate interferon (IFN)-α secretion of human pDC in the presence of HNSCC. IFN-α secretion was measured using the ELISA Technique...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29453437/enhancement-of-immunomodulative-effect-of-lactic-acid-bacteria-on-plasmacytoid-dendritic-cells-with-sucrose-palmitate
#9
Masaya Kanayama, Yukiko Kato, Toshikazu Tsuji, Yuki Konoeda, Akiko Hashimoto, Osamu Kanauchi, Toshio Fujii, Daisuke Fujiwara
Plasmacytoid dendritic cells (pDCs) play a key role in the immune response against viruses. In addition, recent research has suggested that pDCs possess direct and indirect tumoricidal activities. We previously found that a lactic acid bacteria strain, Lactococcus lactis JCM 5805 (LC-Plasma), stimulated pDCs and prevented viral infection in mouse and human studies. Meanwhile, emulsifiers have recently been highlighted as candidate adjuvants for some viral vaccines and cancer immunotherapies. In this study, we discovered some specific emulsifiers, mainly consisting of sucrose fatty acid esters, that drastically enhance the potency of LC-Plasma to activate pDCs in vitro...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444460/plasmacytoid-pre-dendritic-cells-pdc-from-molecular-pathways-to-function-and-disease-association
#10
REVIEW
Solana Alculumbre, Salvatore Raieli, Caroline Hoffmann, Rabie Chelbi, François-Xavier Danlos, Vassili Soumelis
Plasmacytoid pre-dendritic cells (pDC) are a specialized DC population with a great potential to produce large amounts of type I interferon (IFN). pDC are involved in the initiation of antiviral immune responses through their interaction with innate and adaptive immune cell populations. In a context-dependent manner, pDC activation can induce their differentiation into mature DC able to induce both T cell activation or tolerance. In this review, we described pDC functions during immune responses and their implication in the clearance or pathogenicity of human diseases during infection, autoimmunity, allergy and cancer...
February 19, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29431693/an-antigen-free-plasmacytoid-dendritic-cell-targeting-immunotherapy-to-bolster-memory-cd8-t-cells-in-nonhuman-primates
#11
Yuji Masuta, Takuya Yamamoto, Yayoi Natsume-Kitatani, Tomohiro Kanuma, Eiko Moriishi, Kouji Kobiyama, Kenji Mizuguchi, Yasuhiro Yasutomi, Ken J Ishii
The priming, boosting, and restoration of memory cytotoxic CD8+ T lymphocytes by vaccination or immunotherapy in vivo is an area of active research. Particularly, nucleic acid-based compounds have attracted attention due to their ability to elicit strong Ag-specific CTL responses as a vaccine adjuvant. Nucleic acid-based compounds have been shown to act as anticancer monotherapeutic agents even without coadministration of cancer Ag(s); however, so far they have lacked efficacy in clinical trials. We recently developed a second-generation TLR9 agonist, a humanized CpG DNA (K3) complexed with schizophyllan (SPG), K3-SPG, a nonagonistic Dectin-1 ligand...
March 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29417284/biologic-meshes-and-synthetic-meshes-in-cancer-patients-a-double-edged-sword-differences-in-production-of-il-6-and-il-12-caused-by-acellular-dermal-matrices-in-human-immune-cells
#12
Maria Margarete Karsten, Sabine Enders, Julia Knabl, Verena Kirn, Peter Düwell, Brigitte Rack, Jens-Uwe Blohmer, Doris Mayr, Darius Dian
PURPOSE: In 2005, Breuing et al. first described the use of acellular dermal matrices (ADMs) in breast cancer patients. ADMs are assumed to be safe to use in an oncologic setting, but data from controlled studies are still needed. Here, we investigate the effects of ADMs on the production of interleukin (IL)-6 and IL-12, key regulators of immune suppression and activation. METHODS: Strattice (ST), CollaMend (CM), and Biodesign (BD) biologic meshes and TiLoop, a synthetic mesh (TL), were used in this study...
May 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29344995/activation-of-human-cd141-and-cd1c-dendritic-cells-in-vivo-with-combined-tlr-3-and-tlr-7-8-ligation
#13
Frances E Pearson, Karshing Chang, Yoshihito Minoda, Ingrid M Leal Rojas, Oscar L Haigh, Ghazal Daraj, Kirsteen M Tullett, Kristen J Radford
Mice reconstituted with human hematopoietic stem cells are valuable models to study aspects of the human immune system in vivo. We describe a humanized mouse model (hu mice) in which fully functional human CD141+ and CD1c+ myeloid and CD123+ plasmacytoid dendritic cells (DC) develop from human cord blood CD34+ cells in immunodeficient mice. CD141+ DC are the human equivalents of murine CD8+ /CD103+ DC which are essential for the induction of tumor-inhibitory cytotoxic T lymphocyte (CTL) responses, making them attractive targets to exploit for the development of new cancer immunotherapies...
January 18, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29334492/anti-il-10-mediated-enhancement-of-antitumor-efficacy-of-a-dendritic-cell-targeting-mip3%C3%AE-gp100-vaccine-in-the-b16f10-mouse-melanoma-model-is-dependent-on-type-i-interferons
#14
James T Gordy, Kun Luo, Brian Francica, Charles Drake, Richard B Markham
The chemokine MIP3α (CCL20) binds to CCR6 on immature dendritic cells. Vaccines fusing MIP3α to gp100 have been shown to be effective in therapeutically reducing melanoma tumor burden and prolonging survival in a mouse model. Other studies have provided evidence that interleukin-10 (IL-10) neutralizing antibodies (αIL-10) enhance immunologic melanoma therapies by modulating the tolerogenic tumor microenvironment. In the current study, we have utilized the B16F10 syngeneic mouse melanoma model to demonstrate for the first time that a therapy neutralizing IL-10 enhances the antitumor efficacy of a MIP3α-gp100 DNA vaccine, leading to significantly smaller tumors, slower growing tumors, and overall increases in mouse survival...
May 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29230377/clinical-significance-of-circulating-immune-cells-in-left-and-right-sided-colon-cancer
#15
Jiabo Di, Meng Zhuang, Hong Yang, Beihai Jiang, Zaozao Wang, Xiangqian Su
Background: Left-sided and right-sided colon cancers (LCCs and RCCs, respectively) differ in their epidemiology, pathogenesis, genetic and epigenetic alterations, molecular pathways and prognosis. Notably, immune response gene expression profiles have been shown to differ between patients with LCC and patients with RCC. The immune system plays an important role in tumor immunosurveillance, and there is increasing evidence that peripheral blood immune cells have a profound influence on tumor prognosis...
2017: PeerJ
https://www.readbyqxmd.com/read/29209568/phenotype-and-tissue-distribution-of-cd28h-immune-cell-subsets
#16
Joel Crespo, Linda Vatan, Tomasz Maj, Rebecca Liu, Ilona Kryczek, Weiping Zou
CD28H is a newly discovered co-receptor of the human B7 family. CD28H interacts with its ligand B7-H5 and regulates T cell response. Here we showed that CD28H was not expressed on granulocytes, monocytes, myeloid dendritic cells (MDCs), and B cells, but constitutively expressed with moderate levels on memory T cells and with high levels on naïve T cells, innate lymphoid cells (ILCs), natural killer (NK) cells, and plasmacytoid dendritic cells (PDCs) in human peripheral blood. Similar CD28H+ cell profile existed in secondary lymphoid organs and pathological tissues including multiple types of cancers...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29128662/activation-of-innate-immunity-in-primary-human-cells-using-a-plant-virus-derived-nanoparticle-tlr7-8-agonist
#17
Damien Carignan, Sabine Herblot, Marie-Ève Laliberté-Gagné, Marilène Bolduc, Michel Duval, Pierre Savard, Denis Leclerc
Rod-shaped virus-like nanoparticles (VLNP) made of papaya mosaic virus (PapMV) coat proteins (CP) self-assembled around a single stranded RNA (ssRNA) were showed to be a TLR7 agonist. Their utilization as an immune modulator in cancer immunotherapy was shown to be promising. To establish a clinical relevance in human for PapMV VLNP, we showed that stimulation of human peripheral blood mononuclear cells (PBMC) with VLNP induces the secretion of interferon alpha (IFNα) and other pro-inflammatory cytokines and chemokines...
November 8, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29064025/analysis-of-first-year-twitter-metrics-of-a-rare-disease-community-for-blastic-plasmacytoid-dendritic-cell-neoplasm-bpdcn-on-social-media-bpdcn
#18
REVIEW
Naveen Pemmaraju, Audun Utengen, Vikas Gupta, Michael A Thompson, Andrew A Lane
PURPOSE OF REVIEW: The use of Twitter, one of the most commonly engaged social media platforms in the world, is increasing among the general public. Notably, this trend has also been observed among those involved in the healthcare field. With its ability to readily connect diverse groups of stakeholders in a given area of interest, Twitter has become a focal point for those involved in increasing awareness and information exchange in orphan disease fields. Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematologic malignancy with generally poor long-term outcomes for adult patients and no standard therapeutic guidelines...
December 2017: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/28988508/immunological-effects-of-everolimus-in-patients-with-metastatic-renal-cell-cancer
#19
Charlotte M Huijts, Saskia J Santegoets, Tamarah D de Jong, Henk M Verheul, Tanja D de Gruijl, Hans J van der Vliet
The mammalian target of rapamycin (mTOR) is a crucial kinase present in all cells. Besides its role in the regulation of cell-growth, proliferation, angiogenesis, and survival of malignant tumors, mTOR additionally plays an important role in immune regulation by controlling the balance between effector T cells and regulatory T cells (Tregs). This critically affects the suppressive state of the immune system. Here, the systemic immunological effects of everolimus treatment were comprehensively investigated in five patients with metastatic renal cell cancer...
December 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28963110/development-diversity-and-function-of-dendritic-cells-in-mouse-and-human
#20
David A Anderson, Kenneth M Murphy, Carlos G Briseño
The study of murine dendritic cell (DC) development has been integral to the identification of specialized DC subsets that have unique requirements for their form and function. Advances in the field have also provided a framework for the identification of human DC counterparts, which appear to have conserved mechanisms of development and function. Multiple transcription factors are expressed in unique combinations that direct the development of classical DCs (cDCs), which include two major subsets known as cDC1s and cDC2s, and plasmacytoid DCs (pDCs)...
September 29, 2017: Cold Spring Harbor Perspectives in Biology
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