Jian Liang, Weigang Dai, Chuanghui Liu, Yifan Wen, Chen Chen, Yifei Xu, Song Huang, Shaozhen Hou, Chun Li, Yongming Chen, Wei Wang, Hailin Tang
Ulcerative colitis (UC) is a complicated and recurrent intestinal disease. Currently available drugs for UC treatment are scarce, therefore, novel therapeutic drugs for the UC are urgently to be developed. Gingerenone A (GA) is a phenolic compound known for its anti-inflammatory effect, but its effect on UC remains unknown. Here, it is shown that GA protects mice against UC, which is closely associated with inhibiting intestinal mucosal inflammation and enhancing intestinal barrier integrity in vivo and in vitro...
April 19, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)