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https://www.readbyqxmd.com/read/28937552/naspghan-clinical-report-on-postoperative-recurrence-in-pediatric-crohn-disease
#1
Judy B Splawski, Marian D Pffefferkorn, Marc E Schaefer, Andrew S Day, Oliver S Soldes, Todd A Ponsky, Philip Stein, Jess L Kaplan, Shehzad A Saeed
Pediatric Crohn disease is characterized by clinical and endoscopic relapses. The inflammatory process is considered to be progressive and may lead to strictures, fistulas, and penetrating disease that may require surgery. In addition, medically refractory disease may be treated by surgical resection of inflamed bowel in an effort to reverse growth failure. The need for surgery in childhood suggests severe disease and these patients have an increased risk for recurrent disease and potentially more surgery. Data show that up to 55% of patients had clinical recurrence in the first 2 years after initial surgery...
October 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28932369/diagnostic-accuracy-of-fecal-calprotectin-in-assessing-the-severity-of-inflammatory-bowel-disease-from-laboratory-to-clinic
#2
Soheila Moein, Durdi Qujeq, Mostafa Vaghari Tabari, Mehrdad Kashifard, Karimollah Hajian-Tilaki
BACKGROUND: Inflammatory bowel disease (IBD) involves chronic inflammation of the digestive tract. In the past decades, fecal calprotectin has been proposed as a useful biomarker for the differential diagnosis between IBD patients and healthy controls. We designed this study to evaluate the diagnostic ability of fecal calprotectin (FC) and conventional inflammatory markers in IBD patients. METHODS: Thirty patients who underwent colonoscopy were cases and thirty healthy subjects undergoing colonoscopy as part of a medical check-up were the controls...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28922370/ileocolic-resection-is-associated-with-increased-susceptibility-to-injury-in-a-murine-model-of-colitis
#3
Troy Perry, Michael Laffin, Richard N Fedorak, Aducio Thiesen, Bryan Dicken, Karen L Madsen
Ileocolic resection (ICR) is the most common intestinal resection performed for Crohn's disease, with recurrences commonly occurring at the site of the anastomosis. This study used an animal model of ICR in wild-type mice to examine immunologic changes that developed around the surgical anastomosis and how these changes impacted gut responses to minor acute injury. ICR was performed in adult 129S1/SvlmJ mice and results compared with mice receiving sham or no surgery. Dextran sodium sulfate was given either on post-operative day 9 or day 24 to evaluate immune responses in the intestine both immediately following surgery and after a period of healing...
2017: PloS One
https://www.readbyqxmd.com/read/28917233/high-prevalence-of-vitamin-b-12-insufficiency-in-patients-with-crohn-s-disease
#4
Misora Ao, Hidemi Tsuji, Kenichiro Shide, Yuki Kosaka, Akari Noda, Nobuya Inagaki, Hiroshi Nakase, Kiyoshi Tanaka
BACKGROUND AND OBJECTIVES: In Crohn's disease (CD), belonging to inflammatory bowel disease, the small intestine is involved in most cases. Most frequently affected is the distal ileum, where vitamin B-12 is specifically absorbed. Therefore, malabsorption of vitamin B-12 is quite likely to occur in patients with CD. In this study, we have studied the vitamin B-12 status in CD patients. METHODS AND STUDY DESIGN: Forty eight patients with CD were evaluated for their food intake, and circulating concentrations of vitamin B-12, folic acid, and homocysteine (Hcy) as a sensitive marker for the insufficiency of these vitamins and a risk factor of atherosclerosis...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28913968/risk-factors-for-unfavourable-postoperative-outcome-in-patients-with-crohn-s-disease-undergoing-right-hemicolectomy-or-ileocaecal-resection-an-international-audit-by-escp-and-s-ecco
#5
(no author information available yet)
BACKGROUND: Patient and disease-related factors, as well as operation technique all have the potential to impact on postoperative outcome in Crohn's disease. The available evidence is based on small series and often displays conflicting results. AIM: To investigate the effect of pre- and intra-operative risk factors on 30-day postoperative outcome in patients undergoing surgery for Crohn's disease. METHOD: International prospective snapshot audit including consecutive patients undergoing right hemicolectomy or ileocaecal resection...
September 15, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28905225/the-feasibility-and-short-term-clinical-outcomes-of-single-incision-laparoscopic-surgery-for-patients-with-complex-crohn-s-disease
#6
Kiyoshi Maeda, Hisashi Nagahara, Masatsune Shibutani, Tatsunari Fukuoka, Shigetomi Nakao, Hirokazu Yamagami, Noriko Kamata, Kazuya Muguruma, Hiroaki Tanaka, Takahiro Toyokawa, Kosei Hirakawa, Masaichi Ohira
PURPOSE: Single-incision laparoscopic surgery (SILS) offers excellent cosmetic results compared with conventional multi-port laparoscopic surgery. Recently, this technique has been applied to Crohn's disease (CD) with primary ileocolic strictures; however, the application of a laparoscopic approach for complex CD, which involves abscess formation, fistula formation, and recurrent CD, is controversial. The aim of this study was to investigate the safety and feasibility of SILS for patients with complex disease and to compare its clinical results in patients with complex disease vs...
September 13, 2017: Surgery Today
https://www.readbyqxmd.com/read/28903094/effectiveness-of-mesalazine-thiopurines-and-tumour-necrosis-factor-antagonists-in-preventing-post-operative-crohn-s-disease-recurrence-in-a-real-life-setting
#7
Mariangela Allocca, Rosario Landi, Stefanos Bonovas, Gionata Fiorino, Alfredo Papa, Antonino Spinelli, Federica Furfaro, Laurent Peyrin-Biroulet, Alessandro Armuzzi, Silvio Danese
BACKGROUND: Most Crohn's disease (CD) patients develop endoscopic recurrence within one year of intestinal resection. The best treatment method to prevent post-operative CD recurrence remains uncertain. METHODS: A total of 155 CD patients from 2 referral centres, who were undergoing intestinal resection with ileo-colonic anastomosis (January 2004-January 2015), were included. All subjects received preventive therapy with tumour necrosis factor antagonists (anti-TNFs), thiopurinesor mesalazine...
September 14, 2017: Digestion
https://www.readbyqxmd.com/read/28888700/surgical-repair-of-rectovaginal-fistula-using-the-modified-martius-procedure-a-step-by-step-guide
#8
Dan Wang, Juan Chen, Lan Zhu, Mingchen Sang, Fan Yu, Qing Zhou
STUDY OBJECTIVE: to demonstrate the surgical repair of rectovaginal fistula by the modified Martius procedure. DESIGN: step by step presentation of the procedure using video. SETTING: Rectovaginal fistula (RVF) is abnormal epithelialized connections between the vagina and rectum. Causes of rectovaginal fistula include obstetrical trauma, Crohn disease, pelvic irradiation and postsurgical complications. Many surgical interventions have been developed, from laparoscopic technique to muscle transposition and even rectal resection...
September 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28884856/significance-of-measurement-of-serum-trough-level-and-anti-drug-antibody-of-adalimumab-as-personalised-pharmacokinetics-in-patients-with-crohn-s-disease-a%C3%A2-subanalysis-of-the-diamond-trial
#9
H Nakase, S Motoya, T Matsumoto, K Watanabe, T Hisamatsu, N Yoshimura, T Ishida, S Kato, T Nakagawa, M Esaki, M Nagahori, T Matsui, Y Naito, T Kanai, Y Suzuki, M Nojima, M Watanabe, T Hibi
BACKGROUND: Significance of monitoring adalimumab trough levels and anti-adalimumab antibodies (AAA) for disease outcome in Crohn's disease (CD) patients remained unclear. AIM: To evaluate the association of adalimumab trough levels and AAA at week 26 with clinical remission at week 52, the effect of azathiopurine on AAA and factors influencing trough levels in CD patients in the DIAMOND trial. METHODS: We performed this study using adalimumab trough levels, AAA at week 26 and 6-thioguanine nucleotide (TGN) in red blood cells at week 12...
September 8, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28882770/video-assisted-anal-fistula-treatment-vaaft-in-cryptoglandular-fistula-in-ano-a-systematic-review-and-proportional-meta-analysis
#10
REVIEW
Pankaj Garg, Pratiksha Singh
BACKGROUND: Video-Assisted Anal Fistula Treatment (VAAFT) is a relatively new minimally invasive videoendoscopic procedure for treating fistula-in-ano. We reviewed and performed metaanalysis to evaluate the efficacy of this procedure. METHODS: Studies from the period 2010 to 2016 were searched in PubMed, Medline, Scopus, Embase, Ovid, SCI database, Cochrane Central Register of Controlled Trials (CENTRAL) & Google Scholar database. All studies which utilized VAAFT to treat fistula-in-ano were extracted...
September 4, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28852175/risk-factors-for-postoperative-surgical-site-infections-in-patients-with-crohn-s-disease-receiving-definitive-bowel-resection
#11
Song Liu, Ji Miao, Gefei Wang, Meng Wang, Xiuwen Wu, Kun Guo, Min Feng, Wenxian Guan, Jianan Ren
Surgical site infection presents as a significant problem that limits the potential benefits of surgical interventions. This study is to investigate risk factors for postoperative SSI in patients with Crohn's disease receiving definitive bowel resection. A case-control study including 49 patients with SSI and 105 patients without SSI was performed. Demographics, clinical characteristics, laboratory information, medical and surgical data were compared between groups. Significant elements were subsequently brought into logistic regression analysis for further identification...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28835772/faecal-biomarkers-for-screening-small-bowel-inflammation-in-patients-with-crohn-s-disease-a-prospective-study
#12
Takahiro Shimoyama, Takayuki Yamamoto, Satoru Umegae, Koichi Matsumoto
BACKGROUND: The value of faecal biomarkers for screening small bowel inflammation in patients with Crohn's disease (CD) remains to be elucidated. This prospective study was to evaluate the utility of faecal biomarkers for detecting small intestinal inflammation. METHODS: A total of 122 consecutive patients with a diagnosis of CD in the small intestine were screened for eligibility. Computed tomography enterography (CTE) was undertaken to evaluate small bowel inflammation followed by colonoscopy to confirm no large bowel involvement...
August 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28823012/ratio-of-circulating-estrogen-receptors-beta-and-alpha-er%C3%AE-er%C3%AE-indicates-endoscopic-activity-in-patients-with-crohn-s-disease
#13
Pablo M Linares, Alicia Algaba, Ana Urzainqui, Mercedes Guijarro-Rojas, Rafael González-Tajuelo, Jesús Garrido, María Chaparro, Javier P Gisbert, Fernando Bermejo, Iván Guerra, Víctor Castellano, María-Encarnación Fernández-Contreras
BACKGROUND: Data supporting a role of female hormones and/or their receptors in inflammatory bowel disease (IBD) are increasing, but most of them are derived from animal models. Estrogen receptors alpha (ERα) and beta (ERβ) participate in immune and inflammatory response, among a variety of biological processes. Their effects are antagonistic, and the net action of estrogens may depend on their relative proportions. AIM: To determine the possible association between the balance of circulating ERβ and ERα (ERβ/ERα) and IBD risk and activity...
August 19, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28818730/enterohepatic-fistula-in-a-crohn-s-disease-patient-a-case-report
#14
Justin T Van Backer, Edward C Lee
INTRODUCTION: Fistulous tracts are a hallmark of Crohn's Disease. However, solid organ to intestinal fistulas are rare with previously few case reports of colosplenic fistulas and one case report of an enterohepatic fistula. PRESENTATION OF CASE: We review the available literature and present the first case report of an enterohepatic fistula in a female with Crohn's Disease to be treated operatively. The patient did well postoperatively with complete resolution of her fistula...
August 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28817462/fecal-calprotectin-more-accurately-predicts-endoscopic-remission-of-crohn-s-disease-than-serological-biomarkers-evaluated-using-balloon-assisted-enteroscopy
#15
Kousaku Kawashima, Shunji Ishihara, Takafumi Yuki, Nobuhiko Fukuba, Hiroki Sonoyama, Hideaki Kazumori, Noritsugu Yamashita, Yasumasa Tada, Ryusaku Kusunoki, Akihiko Oka, Naoki Oshima, Yoshiyuki Mishima, Ichiro Moriyama, Yoshikazu Kinoshita
BACKGROUND: Fecal calprotectin (FC) has emerged as a reliable surrogate marker of endoscopic remission in Crohn's disease (CD), which has been mainly evaluated using ileocolonoscopy. We conducted this study to clarify the predictability of FC level for predicting endoscopic remission using balloon-assisted enteroscopy (BAE) findings in patients with CD and compare with that of conventional serological biomarkers. METHODS: Patients with CD scheduled to undergo BAE were prospectively enrolled, and fecal and blood samples collected before the procedures...
August 16, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28796069/assessment-of-therapeutic-response-in-crohn-s-disease-using-quantitative-dynamic-contrast-enhanced-mri-dce-mri-parameters-a-preliminary-study
#16
Jianguo Zhu, Faming Zhang, Jinfa Zhou, Haige Li
The aim of the study was to investigate dynamic contrast enhanced MRI (DCE-MRI) as a potential marker to assess the therapeutic responses of fecal microbiota transplantation (FMT) in patients with Crohn's disease (CD) and to determine the parameter or combination of parameters most strongly associated with changes in clinical indicators after treatment.In 22 CD patients, DCE-MRI was performed with a 3.0T scanner. Parameters of DCE-MRI (vascular transfer constant [K] and blood volume [BV]) in the terminal ileum were compared between before and day 90 after FMT treatment...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28738237/a-case-report-of-unexpected-pathology-within-an-incarcerated-ventral-hernia
#17
Erica D Kane, Katharine R Bittner, Michelle Bennett, John R Romanelli, Neal E Seymour, Jacqueline J Wu
INTRODUCTION: Incidence of hernial appendicitis is 0.008%, most frequently within inguinal and femoral hernias. Up to 2.5% of appendectomy patients are found to have Crohn's disease. Elucidating the etiology of inflammation is essential for directing management. PRESENTATION OF CASE: A 51-year-old female with achondroplastic dwarfism, multiple cesarean sections, and subsequent massive incisional hernia, presented with ruptured appendicitis within her incarcerated hernia...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28731502/histologic-scoring-indices-for-evaluation-of-disease-activity-in-crohn-s-disease
#18
REVIEW
Gregor Novak, Claire E Parker, Rish K Pai, John K MacDonald, Brian G Feagan, William J Sandborn, Geert D'Haens, Vipul Jairath, Reena Khanna
BACKGROUND: Histologic assessment of mucosal disease activity has been increasingly used in clinical trials of treatment for Crohn's disease. However, the operating properties of the currently existing histologic scoring indices remain unclear. OBJECTIVES: A systematic review was undertaken to evaluate the development and operating characteristics of available histologic disease activity indices in Crohn's disease. SEARCH METHODS: Electronic searches of MEDLINE, EMBASE, PubMed, and the Cochrane Library (CENTRAL) databases from inception to 20 July 2016 were supplemented by manual reviews of bibliographies and abstracts submitted to major gastroenterology meetings (Digestive Disease Week, United European Gastroenterology Week, European Crohn's and Colitis Organisation)...
July 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28723856/fecal-matrix-metalloprotease-9-and-lipocalin-2-as-biomarkers-in-detecting-endoscopic-activity-in-patients-with-inflammatory-bowel-diseases
#19
Anthony Buisson, Emilie Vazeille, Régine Minet-Quinard, Marion Goutte, Damien Bouvier, Félix Goutorbe, Bruno Pereira, Nicolas Barnich, Gilles Bommelaer
BACKGROUND: Fecal biomarkers are emerging tools in the assessment of mucosal healing in inflammatory bowel diseases (IBD). GOALS: We aimed to evaluate the accuracy of fecal matrix metalloprotease-9 (MMP-9) and fecal lipocalin-2 (LCN-2) compared with calprotectin in detecting endoscopic activity in IBD STUDY:: Overall, 86 IBD adults underwent colonoscopy consecutively and prospectively, with Crohn's disease Endoscopic Index of Severity (CDEIS) in Crohn's disease (CD) patients or Mayo endoscopic subscore calculation for ulcerative colitis (UC) patients, and stool collection...
July 18, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28717358/clinical-response-to-vedolizumab-in-ulcerative-colitis-patients-is-associated-with-changes-in-integrin-expression-profiles
#20
Friederike Fuchs, Daniela Schillinger, Raja Atreya, Simon Hirschmann, Sarah Fischer, Clemens Neufert, Imke Atreya, Markus F Neurath, Sebastian Zundler
BACKGROUND: Despite large clinical success, deeper insights into the immunological effects of vedolizumab therapy for inflammatory bowel diseases are scarce. In particular, the reasons for differential clinical response in individual patients, the precise impact on the equilibrium of integrin-expressing T cell subsets, and possible associations between these issues are not clear. METHODS: Blood samples from patients receiving clinical vedolizumab therapy were sequentially collected and analyzed for expression of integrins and chemokine receptors on T cells...
2017: Frontiers in Immunology
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