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https://www.readbyqxmd.com/read/29046093/video-assisted-anal-fistula-treatment-a-high-volume-unit-initial-experience
#1
F Y Cheung, N D Appleton, S Rout, R Kalaiselvan, J A Nicholson, A Samad, M Chadwick, R Rajaganeshan
Introduction Perianal fistulas are a common problem. Video-assisted anal fistula treatment is a new technique for the management of this difficult condition. We describe our initial experience with the technique to facilitate the treatment of established perianal fistulas. Methods We reviewed a prospectively maintained database relating to consecutive patients undergoing video-assisted anal fistula treatment in a single unit. Results Seventy-eight consecutive patients had their perianal fistulas treated with video-assistance from November 2014 to June 2016...
October 19, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29037795/the-burden-of-hospital-readmissions-among-pediatric-patients-with-inflammatory-bowel-disease
#2
Edward L Barnes, Bharati Kochar, Millie D Long, Christopher F Martin, Seth D Crockett, Joshua R Korzenik, Michael D Kappelman
OBJECTIVE: To evaluate the burden and predictors of hospital readmissions among pediatric patients with inflammatory bowel disease using the Nationwide Readmissions Database. STUDY DESIGN: We performed a retrospective cohort study using 2013 Nationwide Readmissions Database. International Classification of Diseases, Ninth Revision, Clinical Modification codes were used to identify patients <18 years with diagnoses of ulcerative colitis (UC) or Crohn's disease (CD)...
October 13, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29029152/surgical-treatment-in-childhood-onset-inflammatory-bowel-disease-a-nationwide-register-based-study-of-4-695-incident-patients-in-sweden-2002-2014
#3
Caroline Nordenvall, Oda Rosvall, Matteo Bottai, Åsa H Everhov, Petter Malmborg, Karin E Smedby, Anders Ekbom, Johan Askling, Jonas F Ludvigsson, Pär Myrelid, Ola Olén
Background and Aims: The incidence of childhood-onset (<18 years) inflammatory bowel disease is increasing worldwide, and some studies suggest that it represents a more severe disease phenotype. Few nationwide, population-based studies have evaluated the surgical burden in patients with childhood-onset IBD, and whether the improved medical treatment has influenced the need for gastrointestinal surgery. The aim was to examine whether the surgical treatment at any age of patients with childhood-onset IBD has changed over time...
September 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29028958/development-of-clinical-prediction-models-for-surgery-and-complications-in-crohn-s-disease
#4
Leonardo Guizzetti, Guangyong Zou, Reena Khanna, Parambir S Dulai, William J Sandborn, Vipul Jairath, Brian G Feagan
Background and Aims: Crohn's disease-related complications account for a substantial proportion of inflammatory bowel disease-associated healthcare expenditure. Identifying patients at risk for complications may allow for targeted use of early therapeutic interventions to off-set this natural course. We aimed to develop risk prediction models for Crohn's disease-related surgery and complications. Methods: Using data from the Randomized Evaluation of an Algorithm for Crohn's Disease cluster-randomized clinical Trial (REACT), which involved 1898 patients from 40 community practices...
September 19, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29023532/risk-factors-for-gallstones-and-kidney-stones-in-a-cohort-of-patients-with-inflammatory-bowel-diseases
#5
Stefania Fagagnini, Henriette Heinrich, Jean-Benoît Rossel, Luc Biedermann, Pascal Frei, Jonas Zeitz, Marianne Spalinger, Edouard Battegay, Lukas Zimmerli, Stephan R Vavricka, Gerhard Rogler, Michael Scharl, Benjamin Misselwitz
BACKGROUND: Gallstones and kidney stones are known complications of inflammatory bowel diseases (IBD). Risk factors have been insufficiently studied and explanatory studies date back up to 30 years. It remains unclear, whether improved treatment options also influenced risk factors for these complications. OBJECTIVES: Identifying risk factors for gallstones and kidney stones in IBD patients. METHODS: Using data from the Swiss Inflammatory Bowel Disease Cohort Study we assessed associations of diseases characteristics with gallstones and kidney stones in univariate and multivariate logistic regression analyses...
2017: PloS One
https://www.readbyqxmd.com/read/29019856/cost-utility-analysis-thiopurines-plus-endoscopy-guided-biological-step-up-therapy-is-the-optimal-management-of-postoperative-crohn-s-disease
#6
Roberto Candia, David Naimark, Beate Sander, Geoffrey C Nguyen
BACKGROUND: Postoperative recurrence of Crohn's disease is common. This study sought to assess whether the postoperative management should be based on biological therapy alone or combined with thiopurines and whether the therapy should be started immediately after surgery or guided by either endoscopic or clinical recurrence. METHODS: A Markov model was developed to estimate expected health outcomes in quality-adjusted life years (QALYs) and costs in Canadian dollars (CAD$) accrued by hypothetical patients with high recurrence risk after ileocolic resection...
November 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29019151/bariatric-surgery-is-acceptably-safe-in-obese-inflammatory-bowel-disease-patients-analysis-of-the-nationwide-inpatient-sample
#7
Fateh Bazerbachi, Tarek Sawas, Eric J Vargas, Samir Haffar, Parakkal Deepak, John B Kisiel, Edward V Loftus, Barham K Abu Dayyeh
BACKGROUND: The prevalence of obesity in patients with inflammatory bowel disease (IBD) has increased over the past decades. Data to support the safety of bariatric surgery (BAR) in IBD remain scarce. Our aim was to evaluate the safety and early postoperative complications of BAR in IBD patients. METHODS: We used the Nationwide Inpatient Sample (NIS) 2011, 2012, and 2013 to perform a cohort study. The study group was all hospitalized patients between ages 18-90 years who underwent BAR with a discharge diagnosis of IBD as per the Ninth International Classification of Diseases codes (ICD-9)...
October 10, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29018276/ibd-step-up-vs-top-down-therapy-for-crohn-s-disease-medicine-vs-surgery
#8
Bo Shen
No abstract text is available yet for this article.
October 11, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29017707/surgery-in-ileocaecal-crohn-s-disease-one-more-option-sometimes-the-best
#9
Fernando Gomollón
No abstract text is available yet for this article.
November 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29017297/endoscopic-balloon-dilation-for-crohn-s-disease-associated-strictures
#10
REVIEW
Thomas Klag, Jan Wehkamp, Martin Goetz
Management of intestinal strictures associated with Crohn's disease (CD) is clinically challenging despite advanced medical therapy directed toward mucosal healing to positively influence the natural course of CD-associated complications. Although medical therapy is available for inflammatory strictures, therapy of fibrostenotic strictures is the domain of surgery and endoscopy. Endoscopic balloon dilation (EBD) has been recognized as a well-established first-line procedure in terms of safety and efficacy. Although surgery is a valuable treatment modality for the management of CD-related strictures, EBD can help prevent multiple surgical interventions, which might in the long-term lead to a risk of short bowel syndrome...
September 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28994131/systematic-review-and-meta-analysis-assessment-of-factors-affecting-disability-in-inflammatory-bowel-disease-and-the-reliability-of-the-inflammatory-bowel-disease-disability-index
#11
REVIEW
B Lo, M V Prosberg, L L Gluud, W Chan, R W Leong, E van der List, M van der Have, H Sarter, C Gower-Rousseau, L Peyrin-Biroulet, I Vind, J Burisch
BACKGROUND: The Inflammatory Bowel Disease Disability Index (IBD-DI) has recently been developed for patients with Crohn's disease (CD) and ulcerative colitis (UC). AIM: To assess the severity of disability and associated factors using the IBD-DI, and review the validity of the IBD-DI as a tool. METHOD: Systematic review of cross-sectional studies. Patients included had UC or CD and were classified as active, in remission, or needing surgery, biological and/or steroid treatment...
October 9, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28993262/outcomes-7-years-after-infliximab-withdrawal-for-patients-with-crohn-s-disease-in-sustained-remission
#12
Catherine Reenaers, Jean-Yves Mary, Maria Nachury, Yoram Bouhnik, David Laharie, Matthieu Allez, Mathurin Fumery, Aurélien Amiot, Guillaume Savoye, Romain Altwegg, Martine Devos, Georgia Malamut, Arnaud Bourreille, Bernard Flourie, Philippe Marteau, Lucine Vuitton, Benoît Coffin, Stéphanie Viennot, Jérôme Lambert, Jean-Frédéric Colombel, Edouard Louis
BACKGROUND & AIMS: Little is known about long-term outcomes of patients with Crohn's disease (CD) after infliximab withdrawal. We aimed to describe the long-term outcomes of patients with CD in clinical remission after infliximab treatment was withdrawn. METHODS: We performed a retrospective analysis of data from the 115 patients included in the infliximab discontinuation in patients with CD in stable remission on combined therapy with anti-metabolites (STORI) study, performed at 20 centers in France and Belgium from March 2006 through December 2009...
October 6, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28991890/delayed-diagnosis-is-associated-with-early-and-emergency-need-for-first-crohn-s-disease-related-intestinal-surgery
#13
Zhiwu Hong, Jianan Ren, Yuan Li, Gefei Wang, Guosheng Gu, Xiuwen Wu, Huajian Ren, Jieshou Li
BACKGROUND Increasing evidence suggests that delayed diagnosis in Crohn's disease is associated with a complicated disease course. The aim of this study was to explore the association between delayed diagnosis and the timing of the first Crohn's disease-related intestinal surgery. MATERIAL AND METHODS A retrospective study included 215 Crohn's disease patients with previous surgical history in the Department of General Surgery of Jinling Hospital, China, between January 2013 and March 2016. Data were collected on demographics, clinical characteristics, medication history, and operation history...
October 9, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28991085/crohn-s-disease-of-the-pouch-a-true-diagnosis-or-an-oversubscribed-diagnosis-of-exclusion
#14
Amy L Lightner, Joel G Fletcher, John H Pemberton, Kellie L Mathis, Laura E Raffals, Thomas Smyrk
BACKGROUND: After IPAA, 8% of patients with ulcerative colitis are later diagnosed with Crohn's disease of the pouch, associated with an increased rate of pouch failure. No study has reported on how often the clinical diagnosis is correlated with histologic findings of Crohn's disease in the excised pouch. OBJECTIVE: The purpose of this study was to determine whether the clinical diagnosis is consistent with pathologic confirmation at pouch excision. SETTINGS: The study was conducted at a tertiary IBD referral center...
November 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28988059/ionizing-diagnostic-radiation-exposure-in-patients-with-crohn-s-disease-a-retrospective-study-in-a-medium-hospital-and-its-predictive-factors
#15
Esther Merino Rodríguez, Elisa Carrera Alonso, Miguel Torralba González de Suso, Marta Sánchez da Silva, María Martínez López, María Dolores Sánchez-Tembleque Zarandona
INTRODUCTION: It is estimated that diagnostic medical radiation exposure may be responsable for 0.5-2% of cancers worldwide. Because of the relapsing course of Crohn's disease (CD), these patients usually requiere multiple ionizing radiation test. OBJECTIVE: Stimating the total cumulative effective dose received by our CD patients and identifying the risk factors associated with the exposure to a cumulative effective dose due to the disease (CEED) > 50mSv. MATERIALS AND METHODS: Retrospective cohort study (2001-2014)...
October 4, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28983688/inflammatory-bowel-disease-in-patients-with-hirschsprung-s-disease-a-systematic-review-and-meta-analysis
#16
H Nakamura, T Lim, P Puri
AIM AND OBJECTIVES: Hirschsprung-associated enterocolitis (HAEC) continues to be an important cause of morbidity in patients with Hirschsprung's disease (HSCR). HAEC can occur at any time during the course of the disease. The reported incidence of HAEC before surgery ranges from 6 to 50%, and after surgery, it ranges from 2 to 35%. HAEC and inflammatory bowel disease (IBD) have similar clinical presentation including diarrhea, hematochezia, and abdominal pain. In recent years, isolated cases of IBD have been reported in patients who had surgical treatment for HSCR...
October 5, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28981768/risk-stratification-for-surgery-in-stricturing-ileal-crohn-s-disease-the-bacardi-risk-model
#17
Peter Bossuyt, Celine Debeuckelaere, Marc Ferrante, Anthony de Buck van Overstraeten, Dirk Vanbeckevoort, Thomas Billiet, Albert Wolthuis, Isabelle Cleynen, Gert Van Assche, Andre D'Hoore, Séverine Vermeire
Background and Aim: Transmural inflammation in Crohn's disease [CD] leads to stricturing or penetrating complications. Factors impacting on the need and timing of surgery in ileal stricturing CD [IS-CD] are understudied. Our aim was to identify risk factors in IS-CD associated with the need for surgery over time. Methods: All cross-sectional imaging [XSI] performed for CD between 2006 and 2015 in a tertiary referral centre was analysed. The electronic charts of patients with IS-CD were reviewed for demographic, clinical, biochemical, imaging, genetic, and endoscopic factors...
August 3, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28981652/prevalence-of-malnutrition-and-nutritional-characteristics-of-patients-with-inflammatory-bowel-disease
#18
María José Casanova, Maria Chaparro, Begoña Molina, Olga Merino, Ricardo Batanero, Carmen Dueñas-Sadornil, Pilar Robledo, Ana María Garcia-Albert, Maria Bienvenida Gómez-Sánchez, Xavier Calvet, Maria Del Roser Trallero, Miguel Montoro, Iria Vázquez, Mara Charro, Amaya Barragán, Francisco Martínez-Cerezo, Isabel Megias-Rangil, José María Huguet, Ezequiel Marti-Bonmati, Marta Calvo, Mariana Campderá, Margarita Muñoz-Vicente, Angel Merchante, Ansel David Ávila, Pilar Serrano-Aguayo, Ruth De Francisco, Daniel Hervías, Luis Bujanda, Gloria Esther Rodriguez, Luisa Castro-Laria, Manuel Barreiro-de Acosta, Manuel Van Domselaar, Patricia Ramirez de la Piscina, Javier Santos-Fernández, Alicia Algaba, Sandra Torra, Liliana Pozzati, Pilar López-Serrano, Maria Del Rosario Arribas, Maria Luisa Rincón, Andrés Camilo Peláez, Elena Castro, Antonio García-Herola, Cecilio Santander, Moisés Hernández-Alonso, Elisa Martín-Noguerol, María Gómez-Lozano, Tamara Monedero, Albert Villoria, Ariadna Figuerola, Andrés Castaño-García, Jesús M Banales, Laura Díaz-Hernández, Federico Argüelles-Arias, Javier López-Díaz, Isabel Pérez-Martínez, Noelia García-Talavera, Olivia Karina Nuevo-Siguairo, Sabino Riestra, Javier P Gisbert
Aims: This study sought to determine the prevalence of malnutrition in patients with inflammatory bowel disease, to analyse the dietary beliefs and behaviours of these patients, to study their body composition, to evaluate their muscular strength and to identify the factors associated with malnutrition in these patients. Methods: This was a prospective, multicentre study. Crohn's disease and ulcerative colitis patients from 30 Spanish centres, from the outpatient clinics, were included...
July 24, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28981627/validity-of-contrast-enhanced-ultrasonography-and-dynamic-contrast-enhanced-mr-enterography-in-the-assessment-of-transmural-activity-and-fibrosis-in-crohn%C3%A2-s-disease
#19
Rune Wilkens, Rikke H Hagemann-Madsen, David A Peters, Agnete H Nielsen, Charlotte B Nørager, Henning Glerup, Klaus Krogh
Background and Aims: Increased small intestinal wall thickness correlates with both inflammatory activity and fibrosis in Crohn's disease (CD). Assessment of perfusion holds promise as an objective marker distinguishing between the two conditions. Our primary aim was to determine if relative bowel wall perfusion measurements correlate with histopathological scores for inflammation or fibrosis in CD. Methods: Twenty-five patients were investigated prior to elective surgery for small intestinal CD...
August 3, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28980821/enteral-nutrition-is-associated-with-a-decreased-risk-of-surgical-intervention-in-crohn-s-disease-patients-with-spontaneous-intra-abdominal-abscess
#20
Xiao-Bin Zheng, Xiang Peng, Xiao-Yu Xie, Lei Lian, Xian-Rui Wu, Jian-Cong Hu, Xiao-Wen He, Jia Ke, Yu-Feng Chen, Min Zhi, Xiao-Jian Wu, Xiao-Sheng He, Ping Lan
BACKGROUND: The impact of enteral nutrition (EN) on surgical risk in Crohn's disease (CD) patients suffering from spontaneous intra-abdominal abscess (IAA) was evaluated. METHODS: CD patients diagnosed with spontaneous IAA from 2008 to 2015 were included in the study. The impact of EN on surgical risk was evaluated using both univariate and multivariate analyses. RESULTS: A total of 87 patients were enrolled, 66 (75.9%) were male. The mean age at the development of an abscess was 30...
October 5, 2017: Revista Española de Enfermedades Digestivas
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