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https://www.readbyqxmd.com/read/28719595/risk-of-postoperative-complications-among-inflammatory-bowel-disease-patients-treated-preoperatively-with-vedolizumab
#1
Akihiro Yamada, Yuga Komaki, Nayan Patel, Fukiko Komaki, Arthur S Aelvoet, Anthony L Tran, Joel Pekow, Sushila Dalal, Russell D Cohen, Lisa Cannon, Konstantin Umanskiy, Radhika Smith, Roger Hurst, Neil Hyman, David T Rubin, Atsushi Sakuraba
OBJECTIVES: Vedolizumab is increasingly used to treat patients with ulcerative colitis (UC) and Crohn's disease (CD), however, its safety during the perioperative period remains unclear. We compared the 30-day postoperative complications among patients treated preoperatively with vedolizumab, anti-tumor necrosis factor (TNF)-α agents or non-biological therapy. METHODS: The retrospective study cohort was comprised of patients receiving vedolizumab, anti-TNF-α agents or non-biological therapy within 4 weeks of surgery...
July 18, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28711286/novel-therapeutic-targets-for-inflammatory-bowel-disease
#2
REVIEW
Marjorie Argollo, Gionata Fiorino, Pieter Hindryck, Laurent Peyrin-Biroulet, Silvio Danese
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and Ulcerative Colitis (UC), are immune mediated conditions associated with progressive damage of the inflamed gut tissue, and have a considerable impact on the patient's quality of life. The pathogenesis remains uncertain, but it is clear that complex mechanisms associated with host and luminal factors are involved, generating an unbalance between pro- and anti-inflammatory signaling. It is well established that the purpose of an adequate and complete control of the intestinal inflammation measured not only by clinical symptoms, but also with more objective data such as fecal biomarkers (calprotectin) and endoscopy...
July 12, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28706415/role-of-new-endoscopic-techniques-in-inflammatory-bowel-disease-management-has-the-change-come
#3
EDITORIAL
Loredana Goran, Lucian Negreanu, Ana Maria Negreanu
Despite significant therapeutic progress in recent years, inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, remains a challenge regarding its pathogenesis and long-term complications. New concepts have emerged in the management of this disease, such as the "treat-to-target" concept, in which mucosal healing plays a key role in the evolution of IBD, the risk of recurrence and the need for surgery. Endoscopy is essential for the assessment of mucosal inflammation and plays a pivotal role in the analysis of mucosal healing in patients with IBD...
June 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28694669/magnetic-resonance-imaging-may-predict-deep-remission-in-patients-with-perianal-fistulizing-crohn-s-disease
#4
Lucie Thomassin, Laura Armengol-Debeir, Cloé Charpentier, Valerie Bridoux, Edith Koning, Guillaume Savoye, Céline Savoye-Collet
AIM: To evaluate the imaging course of Crohn's disease (CD) patients with perianal fistulas on long-term maintenance anti-tumor necrosis factor (TNF)-α therapy and identify predictors of deep remission. METHODS: All patients with perianal CD treated with anti-TNF-α therapy at our tertiary care center were evaluated by magnetic resonance imaging (MRI) and clinical assessment. Two MR examinations were performed: at initiation of anti-TNF-α treatment and then at least 2 years after...
June 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28694133/ectopic-pregnancy-in-women-with-inflammatory-bowel-disease-a-22-year-nationwide-cohort-study
#5
Punyanganie S de Silva, Helene H Hansen, Sonja Wehberg, Sonia Friedman, Bente M Nørgård
BACKGROUND & AIMS: Data on early adverse pregnancy outcomes in inflammatory bowel disease (IBD) such as ectopic pregnancy (EP) remain limited. We assessed the risk of EP in pregnancies of Danish women with IBD compared to all other Danish women over a 22-year period. In addition, we examined the disease-specific risk of EP in pregnancies of women with ulcerative colitis (UC) or Crohn's disease (CD) who underwent IBD-related surgical procedures. METHODS: We obtained nationwide data in all women of child-bearing age who had at least one pregnancy resulting in either an EP, hydatiform mole, induced abortion, miscarriage, or live birth from January 1994 through 2015...
July 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28694132/inflammatory-bowel-disease-and-small-bowel-cancer-risk-clinical-characteristics-and-histopathology-a-population-based-study
#6
Rasmus Dahlin Bojesen, Lene Buhl Riis, Estrid Høgdall, Ole Haagen Nielsen, Tine Jess
BACKGROUND & AIMS: Inflammatory bowel disease (IBD) may increase risk of small bowel cancer (SBC). However, little is known of the characteristics and features of IBD-SBC, due to a low number of cases worldwide. We performed a population-based study of IBD and SBC to calculate risk and increase our understanding of clinical characteristics and histopathological and molecular features. METHODS: The study population consisted of all individuals 16 years or older living in Denmark during 1978-2010...
July 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28691940/endoscopic-balloon-dilation-size-and-avoidance-of-surgery-in-stricturing-crohn-s-disease
#7
Bethany A Reutemann, Joshua A Turkeltaub, Mahmoud Al-Hawary, Akbar K Waljee, Peter D R Higgins, Ryan W Stidham
BACKGROUND: Endoscopic balloon dilation (EBD) is an effective method for treating stricture-related obstruction in Crohn's disease. We aimed to identify factors predictive of successful avoidance of surgery, including endoscopic features, in patients undergoing balloon dilation. METHODS: We performed a retrospective review of patients with symptomatic Crohn's disease-related intestinal strictures undergoing EBD. Clinical, medication use, laboratory, and dilation data, including the minimum and maximum balloon sizes used, and number of balloons used per endoscopic session were collected...
July 6, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28691939/autoantibodies-against-glycoprotein-2-isoforms-in-pediatric-patients-with-inflammatory-bowel-disease
#8
Nadja Röber, Lydia Noß, Alexander Goihl, Dirk Reinhold, Josefine Jahn, Jan de Laffolie, Wolf Johannes, Gunter M Flemming, Dirk Roggenbuck, Karsten Conrad, Martin W Laass
BACKGROUND: Anti-Glycoprotein 2 (GP2) antibodies are associated with a more complicated course of Crohn's disease (CD) in adults. Four different GP2 isoforms with different length and antibody-binding sites have been identified so far but not been explored in serological studies. We aimed to investigate the diagnostic utility of autoantibodies against all 4 isoforms of GP2 in an exclusively pediatric population for the first time. METHODS: We included 278 children and adolescents with inflammatory bowel disease: 164 with CD, 114 with ulcerative colitis, 83 disease controls (acute gastrointestinal infection, nonspecific gastrointestinal functional disorders), and 219 healthy controls...
July 6, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28682975/surgery-for-colorectal-cancer-in-crohn-s-disease-should-we-perform-a-total-proctocolectomy-for-all-patients-with-high-grade-dysplasia-and-cancer-in-crohn-s-disease
#9
https://www.readbyqxmd.com/read/28682970/validation-of-risk-factors-for-fecal-incontinence-in-patients-with-crohn-s-disease
#10
Paul F Vollebregt, Arjan P Visscher, Adriaan A van Bodegraven, Richelle J F Felt-Bersma
BACKGROUND: Fecal incontinence has a great impact on daily life, and many patients are reluctant to report it. OBJECTIVE: The purpose of this study was to estimate the prevalence of fecal incontinence in patients with Crohn's disease, validate risk factors, and relate outcome with quality of life. DESIGN: The design was cross-sectional. SETTINGS: The study was conducted at an academic tertiary center. PATIENTS: Consecutive patients with Crohn's disease treated between 2003 and 2013 were included in this study...
August 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28667431/increase-in-hospital-discharges-for-inflammatory-bowel-diseases-in-chile-between-2001-and-2012
#11
Felipe Bellolio Roth, Javier Gómez, Jaime Cerda
AIM: To determine the number of annual hospital discharges for inflammatory bowel diseases in Chile. The hypothesis is that there is a significant increase in the hospital discharges due to this disease from 2001 to 2012. MATERIALS AND METHODS: This is a descriptive study. Data were obtained from the Web site of the Department of Health Statistics. All hospital discharges from 2001 to 2012 were included. The following variables were analyzed: length of stay, hospital mortality, and eventual surgical procedure...
June 30, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28666947/treatment-with-biologic-agents-has-not-reduced-surgeries-among-patients-with-crohn-s-disease-with-short-bowel-syndrome
#12
Berkeley N Limketkai, Alyssa M Parian, Po-Hung Chen, Jean-Fréderic Colombel
BACKGROUND & AIMS: Little is known about the effects of biologic agents used to treat Crohn's disease (CD) on its long-term complications, such as short bowel syndrome and intestinal failure (SBS-IF). We evaluated trends in small bowel resections and health care utilization among patients with CD with and without SBS-IF. METHODS: We collected data on the National Inpatient Sample on 2,989,185 patients hospitalized with CD in the United States before the time period in which CD was treated with biologic agents (1993 through 1997) and after biologic therapy became widespread (1998 through 2014)...
June 27, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28664992/the-outcome-of-ulcerative-colitis-patients-undergoing-pouch-surgery-is-determined-by-pre-surgical-factors
#13
H Yanai, S Ben-Shachar, L Mlynarsky, L Godny, M Leshno, H Tulchinsky, I Dotan
BACKGROUND: Pouch surgery, a common intervention for ulcerative colitis (UC) complications, is often associated with the development of pouchitis. AIM: To identify predictors of pouch outcome in a cohort of patients with UC. METHODS: We conducted a retrospective unmatched case-cohort study in a tertiary IBD referral centre. Adult patients with UC were classified into the worst phenotype throughout follow-up: normal pouch, a form of chronic pouchitis (either chronic pouchitis or Crohn's like disease of pouch [CLDP]), or episodic recurrent acute pouchitis (RAP)...
June 30, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28658115/decreased-cd8-cd28-cd8-cd28-t-cell-ratio-can-sensitively-predict-poor-outcome-for-patients-with-complicated-crohn-disease
#14
Shi-Xue Dai, Hong-Xiang Gu, Qian-Yi Lin, Yan-Kun Wu, Xiao-Yan Wang, Shao-Zhuo Huang, Tiao-Si Xing, Min-Hua Chen, Qing-Fang Zhang, Zhong-Wen Zheng, Wei-Hong Sha
Crohn disease (CD) with complications such as penetrating, stricturing, and perianal disease is called complicated CD. The aim of this study is to test the efficiency with which the CD8CD28/CD8CD28 cell balance can predict a subsequent active stage in patients with newly diagnosed complicated CD.Seventeen patients with complicated CD and 48 CD patients with no complications were enrolled. Blood CD8 T cells were tested from all of the 65 newly diagnosed CD patients upon enrollment. The potential risk factors were compared between the 2 groups...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28656973/body-composition-assessment-of-crohn-s-outpatients-and-comparison-with-gender-and-age-specific-multiple-matched-control-pairs
#15
A Molnár, Á A Csontos, I Kovács, Á D Anton, E Pálfi, P Miheller
BACKGROUND/OBJECTIVES: Routine clinical care for Crohn's disease (CD) outpatients does not cover the assessment of body composition (BC); although this disease (because of inflammation, surgeries, lack of physical activity and appetite) may have a severe impact on lean body mass. The main aims of this prospective research were to assess the nutritional status of the patients and to compare their data with apparently healthy gender- and age-specific matched control pairs. SUBJECTS/METHODS: Overall, 136 CD patients and 1752 apparently healthy people were involved in the study...
June 28, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28654553/clinical-and-histopathologic-features-of-colorectal-adenocarcinoma-in-crohn-s-disease
#16
Christian Galata, Daniela Hirsch, Wolfgang Reindl, Stefan Post, Peter Kienle, Michael Boutros, Timo Gaiser, Karoline Horisberger
GOALS: The aim of this study was to assess the histopathologic characteristics of colorectal carcinomas (CRC) in patients with Crohn's disease (CD). BACKGROUND: A higher frequency of microsatellite instability (MSI) is seen in mucinous compared with nonmucinous CRC which suggests that its pathogenesis involves distinct molecular pathways. Several publications reported a higher percentage of mucinous adenocarcinoma in CD patients with CRC. So far, there has been no investigation of MSI in CD patients with mucinous CRC...
June 26, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28647686/increased-risk-of-acute-arterial-events-in-young-patients-and-severely-active-ibd-a-nationwide-french-cohort-study
#17
Julien Kirchgesner, Laurent Beaugerie, Fabrice Carrat, Nynne Nyboe Andersen, Tine Jess, Michaël Schwarzinger
OBJECTIVE: Magnitude and independent drivers of the risk of acute arterial events in IBD are still unclear. We addressed this question in patients with IBD compared with the general population at a nationwide level. DESIGN: Using the French National Hospital Discharge Database from 2008 to 2013, all patients aged 15 years or older and diagnosed with IBD were identified and followed up until 31 December 2013. The rates of incident acute arterial events were calculated and the impact of time with active disease (period around hospitalisation for IBD flare or IBD-related surgery) on the risk was assessed by Cox regression adjusted for traditional cardiovascular risk factors...
June 24, 2017: Gut
https://www.readbyqxmd.com/read/28644182/incidence-and-management-of-recurrence-in-patients-with-crohn-s-disease-who-have-undergone-intestinal-resection-the-practicrohn-study
#18
Eugeni Domènech, Valle Garcia, Marisa Iborra, Ana Gutiérrez, Santiago García-López, María D Martín Arranz, Esther Garcia-Planella, Marta Calvo, Luisa Castro, Miguel Mínguez, Carlos Taxonera, Berta Juliá, Luis Cea-Calvo, Cristina Romero, Manuel Barreiro-de Acosta
BACKGROUND: More than 50% of patients with Crohn's disease require intestinal resection at least once. Postoperative recurrence (POR) is almost uniform if prophylactic treatment is not started early. Endoscopic monitoring is generally advised. We studied the incidence and management of recurrence in patients who had undergone intestinal resection. METHODS: Practicrohn was an observational retrospective study performed in 26 Spanish hospitals including patients aged ≥18 years who underwent Crohn's disease-related ileocolonic resection between January 2007 and December 2010...
June 20, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28634703/isoperistaltic-versus-antiperistaltic-side-to-side-anastomosis-after-right-laparoscopic-hemicolectomy-for-cancer-isovanti-trial-study-protocol-for-a-randomised-clinical-trial
#19
N Ibañez, J Abrisqueta, J Luján, Q Hernández, P Parrilla
BACKGROUND: It is believed that loosing ileocecal valve is well tolerated in patients who do not have short bowel syndrome or Crohn disease. From the hypothesis of colonic peristalsis and transit is regulated by that ileocecal valvular mechanism, we try to find out if the creation of a new pseudo-valvular mechanism as antiperistaltic anastomosis could be considered after right hemicolectomy can cause any short- or long-term changes in gastrointestinal habits. PURPOSE: The purpose of the study at primary endpoint is to compare early (occurring within 30 days of surgery) and late (occurring during the follow-up) postoperative complications between both groups The purpose of the study at secondary endpoint is to compare intraoperative and postoperative events between experimental and control groups in terms of operating time, first oral tolerance day, first flatus and faeces, length of hospital stay and orocecal transit; comparing rates of gastrointestinal life quality and comparing mortality rates between both groups...
June 21, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28630777/magnetic-resonance-enterography-findings-of-intestinal-beh%C3%A3-et-disease-in-a-child
#20
Tommaso D'Angelo, Romina Gallizzi, Claudio Romano, Giuseppe Cicero, Silvio Mazziotti
Behçet's disease (BD) is a multisystem disorder of unknown aetiology, characterized by recurrent oral ulcers, genital ulcers, uveitis, skin lesions, and pathergy. Gastrointestinal disease outside the oral cavity is well recognized and usually takes the form of small intestinal ulcers, with the most significant lesions frequently occurring in the ileocaecal region. Symptoms usually include nausea, vomiting, colicky abdominal pain, and change in bowel habit and it is not unusual that patients may present late, with life-threatening complications requiring surgery...
2017: Case Reports in Radiology
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