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rebounding lymphatic

Sagar Pandey, Miao Fan, Dandan Chang, Junfeng Zhu, Ying Zhu, Ziping Li
Hemolymphangioma is a rare vascular developmental error. It comprises malformed venous and lymphatic component in various proportion. To the best of our knowledge, only a few cases have been reported in the literature so far. Here, we report a case of huge intraperitoneal cystic mass in a 3-year-old boy that was presented to hospital with intractable abdominal pain. On examination, he had fever along with associated symptoms like cough and sputum. Abdomen was distended with no tenderness or rebound tenderness...
April 2016: Medicine (Baltimore)
Da-Young Yu, You-Jin Jang, Young-Jae Mok
Paraduodenal hernia is by far the most common form of congenital internal hernia. Chylous ascites is an accumulation of lymphatic fluid in the peritoneal cavity. It develops when the lymphatic system is disrupted due to traumatic injury or obstruction. A 40-year-old, woman showed up to the Emergency Department with severe, colicky abdominal pain. Tenderness and rebound tenderness were observed at the left abdomen. Abdominal CT confirmed a cluster of dilated proximal small bowel loops with ischemic change, without ascites...
November 2015: Annals of Surgical Treatment and Research
Nadir Askenasy
The prevalent current approach to type 1 diabetes (T1D) is the abrogation of pathogenic potential by immunosuppressive therapy, an intuitive approach aiming to slow down disease progression by the reduction of pathogenic burden. In spite of promising initial results in rodent models, there has been little efficacy of most lymphoreductive strategies in human subjects. Our analysis suggests that lymphopenia is the common denominator of ineffective immunosuppressive therapies: Immune rebound from lymphopenia is associated per se with increased susceptibility to immune reactivity, including relapse of autoimmunity...
2015: International Reviews of Immunology
Meghan K Rothenberger, Brandon F Keele, Stephen W Wietgrefe, Courtney V Fletcher, Gregory J Beilman, Jeffrey G Chipman, Alexander Khoruts, Jacob D Estes, Jodi Anderson, Samuel P Callisto, Thomas E Schmidt, Ann Thorkelson, Cavan Reilly, Katherine Perkey, Thomas G Reimann, Netanya S Utay, Krystelle Nganou Makamdop, Mario Stevenson, Daniel C Douek, Ashley T Haase, Timothy W Schacker
Antiretroviral therapy (ART) suppresses HIV replication in most individuals but cannot eradicate latently infected cells established before ART was initiated. Thus, infection rebounds when treatment is interrupted by reactivation of virus production from this reservoir. Currently, one or a few latently infected resting memory CD4 T cells are thought be the principal source of recrudescent infection, but this estimate is based on peripheral blood rather than lymphoid tissues (LTs), the principal sites of virus production and persistence before initiating ART...
March 10, 2015: Proceedings of the National Academy of Sciences of the United States of America
Taniawati Supali, Yenny Djuardi, Mark Bradley, Rahmah Noordin, Paul Rückert, Peter U Fischer
BACKGROUND: The lymphatic filarial parasite Brugia timori occurs only in eastern Indonesia where it causes high morbidity. The absence of an animal reservoir, the inefficient transmission by Anopheles mosquitoes and the high sensitivity to DEC/albendazole treatment make this species a prime candidate for elimination by mass drug administration (MDA). METHODOLOGY/PRINCIPAL FINDINGS: We evaluated the effect of MDA using DEC and albendazole on B. timori and soil transmitted helminths (STH) in a cross-sectional study of a sentinel village on Alor Island annually over a period of 10 years...
2013: PLoS Neglected Tropical Diseases
Klaudia Skrzypek, Magdalena Tertil, Slawomir Golda, Maciej Ciesla, Kazimierz Weglarczyk, Guillaume Collet, Alan Guichard, Magdalena Kozakowska, Jorge Boczkowski, Halina Was, Tomasz Gil, Jaroslaw Kuzdzal, Lucie Muchova, Libor Vitek, Agnieszka Loboda, Alicja Jozkowicz, Claudine Kieda, Jozef Dulak
AIMS: Heme oxygenase-1 (HO-1, HMOX1) can prevent tumor initiation; while in various tumors, it has been demonstrated to promote growth, angiogenesis, and metastasis. Here, we investigated whether HMOX1 can modulate microRNAs (miRNAs) and regulate human non-small cell lung carcinoma (NSCLC) development. RESULTS: Stable HMOX1 overexpression in NSCLC NCI-H292 cells up-regulated tumor-suppressive miRNAs, whereas it significantly diminished the expression of oncomirs and angiomirs...
September 1, 2013: Antioxidants & Redox Signaling
Mariko Horiike, Shingo Iwami, Makoto Kodama, Akihiko Sato, Yuji Watanabe, Mika Yasui, Yuki Ishida, Takeshi Kobayashi, Tomoyuki Miura, Tatsuhiko Igarashi
Attempts to find a cure for HIV infection are hindered by the presence of viral reservoirs that resist highly active antiretroviral therapy. To identify the properties of these reservoirs, four SIV239-infected Rhesus macaques were treated with combined antiretroviral therapy (cART) for 1 year. While plasma viral RNA (vRNA) was effectively suppressed, a systemic analysis revealed that vRNA was distributed in the following order: lymphatic tissues>lungs and intestine>other tissues. Histochemistry yielded no cells with viral signals...
February 20, 2012: Virology
Sammy M Njenga, Charles S Mwandawiro, C Njeri Wamae, Dunstan A Mukoko, Anisa A Omar, Masaaki Shimada, Moses J Bockarie, David H Molyneux
BACKGROUND: The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was established by the World Health Organisation (WHO) in 2000 with the goal of eliminating lymphatic filariasis (LF) as a public health problem globally by 2020. Mass drug administration (MDA) of antifilarial drugs is the principal strategy recommended for global elimination. Kenya launched a National Programme for Elimination of Lymphatic Filariasis (NPELF) in Coast Region in 2002. During the same year a longitudinal research project to monitor trends of LF infection during MDA started in a highly endemic area in Malindi District...
May 25, 2011: Parasites & Vectors
Farbod Nasseri, Farzin Eftekhari
At imaging, the thymus appears in a variety of shapes and sizes, even in the same individual. It gradually involutes with age and may acutely shrink during periods of bodily stress. During the recovery period, it grows back to its original size or even larger, a phenomenon known as thymic rebound hyperplasia. These anatomic variations and dynamic changes appear to be the main source of confusion with pathologic conditions. In turn, these misinterpretations may lead to prolongation or alteration of the chemotherapy regimen or to unnecessary radiation therapy, biopsy, or thymectomy...
March 2010: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Martin J Sadowski, Joanna Pankiewicz, Frances Prelli, Henrieta Scholtzova, Daryl S Spinner, Regina B Kascsak, Richard J Kascsak, Thomas Wisniewski
The pathogenesis of prion diseases is related to conformational transformation of cellular prion protein (PrP(C)) into a toxic, infectious, and self-replicating conformer termed PrP(Sc). Following extracerebral inoculation, the replication of PrP(Sc) is confined for months to years to the lymporeticular system (LRS) before the secondary CNS involvement results in occurrence of neurological symptoms. Therefore, replication of PrP(Sc), in the early stage of infection can be targeted by therapeutic approaches, which like passive immunization have limited blood-brain-barrier penetration...
May 2009: Neurobiology of Disease
P P Sfikakis, G M Gourgoulis, L A Moulopoulos, G Kouvatseas, A N Theofilopoulos, M A Dimopoulos
BACKGROUND: The potential role of the adult thymus in T-cell homeostasis subsequent to lymphopenia remains the subject of debate. We examined whether thymic activity contributes to reconstitution of the peripheral T-cell pool, a critical process for patients recovering from antineoplastic therapy. METHODS: In selected patients with various neoplastic diseases we assessed peripheral blood lymphocyte subsets by flow-cytometry, including thymus-derived, CD4+ T cells expressing the CD45RA molecule, and thymic size rebound by CT scan before, and 3, 6 and 12 months after completion of cytotoxic therapy...
June 2005: European Journal of Clinical Investigation
S Gerhardt, G Gehling, P Schuster
HISTORY AND ADMISSION FINDINGS: A 41-year-old man was admitted, in reduced general condition, having for several hours experienced acute left chest pain and dyspnoea. On examination there was dullness on percussion over the base of the left lung with decreased breath sounds. At the age of 28 years he had been placed on peritoneal dialysis for renal failure due to congenital kidney aplasia. A year later he had been given a renal transplant, which had to be removed a year before admission because of transplant glomerulopathy...
September 10, 2004: Deutsche Medizinische Wochenschrift
Felipe García, Montserrat Plana, Mireia Arnedo, Merçe Brunet, Pedro Castro, Cristina Gil, Elena Vidal, Olga Millán, Anna López, Jaume Martorell, Emilio Fumero, José M Miró, José Alcamí, Tomás Pumarola, Teresa Gallart, José M Gatell
The main goal of this study was to assess the role of mycophenolate mofetil (MMF) during interruption of highly active antiretroviral therapy (HAART). Seventeen patients with early-stage chronic HIV type 1 infection were treated with HAART for 12 months. They were then randomized (day 0) to receive MMF (HAART-MMF group, n = 9) or to continue the regimen (HAART group, n = 6) for 120 additional days. At day 120 in the HAART-MMF group, HAART was discontinued, and MMF administration was continued. The primary end point of the study was the number of individuals maintaining a plasma viral load (VL) set point of <200 copies/mL after at least 6 months off HAART...
July 1, 2004: Journal of Acquired Immune Deficiency Syndromes: JAIDS
B Kriederman, T Myloyde, M Bernas, L Lee-Donaldson, S Preciado, M Lynch, B Stea, P Summers, C Witte, M Witte
Lack of a standardized experimental counterpart of peripheral lymphedema (LE) in a small animal has hampered research into treatment of this debilitating condition. We recently refined a rodent model consisting of radical unilateral lymphatic/nodal groin excision in conjunction with a circumferential integumental gap, followed by regional irradiation of the groin to reproduce stable unilateral hindlimb LE (1). In the current study, Wistar-Fuzzy rats with established right hindlimb LE, were subdivided into five groups and subjected to one of the following daily physical regimens over a 5-day period: pneumatic compression pumping at 30 torr (PCP); low-stretch multi-layered compressive bandaging using Coban (CB); manual lymphedema drainage (MLD) or a light massage consisting of stationary circular motions using the fingertips; combined physiotherapy (CPT consisting of MLD + CB); and a no treatment or control group (CTRL)...
March 2002: Lymphology
F García, M Plana, C Vidal, A Cruceta, W A O'Brien, G Pantaleo, T Pumarola, T Gallart, J M Miró, J M Gatell
BACKGROUND: This study addresses the dynamic of viral load rebound and immune system changes in a cohort of eight consecutive HIV-1-infected patients in very early stages [all the patients were taking highly active antiretroviral therapy (HAART} and were recruited in the coordinating center from a larger study] who decided to discontinue HAART after 1 year of treatment and effective virologic response. The safety of this procedure and the outcome with reintroduction of the same treatment was also investigated...
July 30, 1999: AIDS
K Uematsu
Repeated intravenous injections of 7,12-dimethylbenz(a)anthracene (abbr. DMBA), four times weekly, induced several kinds of tumors in 26 mice (83.9%) out of 31 ddO mice, including 13 leukemias and 6 ovarian tumors. All leukemias were of lymphatic type, and 8 cases out of 13 leukemias were of thymus type. The thymus was involved by leukemic cells in 12 cases. All ovarian tumors were diagnosed as granulosa cell tumors histologically. During the treatment of DMBA, two types of changes in organs and blood were observed: one was a striking decrease of weight or organs or number of cells followed by prompt recovery as found in the spleen, red blood cells, and granulocytes in the peripheral blood; the other was moderate but long-standing decrease with little recovery as found in the thymus, ovaries, uterus, and lymphocytes in the peripheral blood...
September 1981: Acta Pathologica Japonica
H F Sproat, F S Messiha
The effect of short-term injection of chlorpromazine alone or combined with either LiCl or CsCl (1 mEq/kg/day) in organ toxicity was studied in the albino male mouse. Chlorpromazine was administered by gradual dose build-up regimens from 5 mg/kg to 50 mg/kg which was attained over a 40-day period followed by abrupt drug withdrawal for a subsequent 25-day observation period. Histological evaluation of 10 tissues selected indicates that the liver was the target organ. The Li-treatment resulted in variable liver lobular size with loss of cell definition and the kidney showed focal lymphatic aggregates related to vascular channel...
August 1983: Brain Research Bulletin
R Mikami, Y Nomura, M Takao, O Hongo, A Mizoguchi
No abstract text is available yet for this article.
June 1971: Naika. Internal Medicine
K P Dieckmann, W Düe, K J Bauknecht, B Hamm
A space-occupying mediastinal mass was discovered in a 16-year-old boy with metastasizing non-seminomatous testicular tumour six months after successful conclusion of cytostatic chemotherapy. Metastases at other sites were excluded. An enlarged thymus was the only finding at operation. Histological and histochemical examination demonstrated diffuse hyperplasia. The findings demonstrate that reactive benign thymic hyperplasia after cytostatic chemotherapy has to be considered in the differential diagnosis of space-occupying mediastinal lesions...
April 15, 1988: Deutsche Medizinische Wochenschrift
D Foulner
Thymic calcification is usually associated with a thymic neoplasm. A case is reported in which transient calcification preceded rebound thymic enlargement related to chemotherapy, in an otherwise normal thymus.
December 1991: Clinical Radiology
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