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Helicobacter pylori and gastric cancer

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https://www.readbyqxmd.com/read/29927340/the-type-iv-secretion-system-in-helicobacter-pylori
#1
Xiao-Yan Yuan, Ying Wang, Ming-Yi Wang
Helicobacter pylori (H. pylori) has an essential role in the pathogenesis of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. The severity of the host inflammatory responses against the bacteria have been straightly associated with a special bacterial virulence factor, the cag pathogenicity island, which is a type IV secretion system (T4SS) to deliver CagA into the host cells. Besides cag-T4SS, the chromosomes of H. pylori can encode another three T4SSs, including comB, tfs3 and tfs4...
June 21, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29925646/droplet-digital-pcr-detection-of-helicobacter-pylori-clarithromycin-resistance-reveals-frequent-heteroresistance
#2
Lu Sun, Sarah Talarico, Lena Yao, Lihua He, Steve Self, Yuanhai You, Huifang Zhang, Yiyao Zhang, Yongjun Guo, Guodong Liu, Nina R Salama, Jianzhong Zhang
Chronic infection with Helicobacter pylori causes peptic ulcers and stomach cancer in a subset of those infected. While standard eradication therapy includes multiple antibiotics, treatment failure due to resistance is an increasing clinical problem. Accurate assessment of H. pylori antimicrobial resistance has been limited by slow growth and sampling of few isolates per subject. We established a method to simultaneously quantify H. pylori clarithromycin resistance (mutant) and susceptible (wild-type) 23S rRNA gene alleles in both stomach and stool samples using droplet digital PCR (ddPCR)...
June 20, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29924436/early-detection-of-gastric-cancer-after-helicobacter-pylori-eradication-due-to-endoscopic-surveillance
#3
Kosuke Sakitani, Toshihiro Nishizawa, Masahide Arita, Shuntaro Yoshida, Yosuke Kataoka, Daisuke Ohki, Hiroharu Yamashita, Yoshihiro Isomura, Akira Toyoshima, Hidenobu Watanabe, Toshiro Iizuka, Yutaka Saito, Junko Fujisaki, Naohisa Yahagi, Kazuhiko Koike, Osamu Toyoshima
BACKGROUND: Helicobacter pylori eradication therapy is commonly performed to reduce the incidence of gastric cancer. However, gastric cancer is occasionally discovered even after successful eradication therapy. Therefore, we examined the prognosis of gastric cancer patients, diagnosed after successful H. pylori eradication therapy. MATERIALS AND METHODS: All-cause death rates and gastric cancer-specific death rates in gastric cancer patients who received successful H...
June 20, 2018: Helicobacter
https://www.readbyqxmd.com/read/29908307/caga-and-vaca-allelic-combination-of-helicobacter-pylori-in-gastroduodenal-disorders
#4
Farajzadah Sheikh Ahmad, Mohammad Jaafar Yadyad, Hamed Goodarzi, Seyed Jalal Hashemi, Sajad Aslani, Mohammad-Ali Assarzadegan, Reza Ranjbar
BACKGROUND: Allelic variation of the virulence genes, vacA and cagA, as the most important virulence associated genes play an important role in the pathogenesis of severe gastrointestinal disease. OBJECTIVE: The aim of the present study was to identify the diversity of the virulence genes in patients with Gastric Cancer (GC), who were referred to the gastro-endoscopy unit of Imam Khomeini Hospital, Ahvaz Jundishapur University of medical science, Ahvaz, Iran. METHODS: Gastric biopsy specimens from 301 patients suspected to gastrointestinal disorders, were analyzed for H...
June 13, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29907681/case-studies-of-gastric-lung-and-oral-cancer-connect-etiologic-agent-prevalence-to-cancer-incidence
#5
Andrew F Brouwer, Marisa C Eisenberg, Rafael Meza
Obtaining detailed individual-level data on both exposure and cancer outcomes is challenging, and it is difficult to understand and characterize how temporal aspects of exposures translate into cancer risk. We show that, in lieu of individual-level information, population-level data on cancer incidence and etiologic agent prevalence can be leveraged to investigate cancer mechanisms and to better characterize and predict cancer trends. We use mechanistic carcinogenesis models [multistage clonal expansion (MSCE) models] and data on smoking, Helicobacter pylori ( H...
June 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29907086/potential-risk-factors-and-prevalence-of-helicobacter-pylori-infection-among-adult-patients-with-dyspepsia-symptoms-in-cameroon
#6
Laure Brigitte Kouitcheu Mabeku, Michelle Larissa Noundjeu Ngamga, Hubert Leundji
BACKGROUND: Helicobacter pylori is a Gram negative bacterium that colonizes the stomach of approximately two-thirds of the human population and it is involved in the pathogenesis of gastroduodenal diseases. This study sought to determine potential risk factors associated with seroprevalence of H. pylori among dyspepsia patients in Cameroon for a better management of the disease. METHODS: The study was carried out from August to December 2014 at Laquintinie Hospital and District Hospital of Bonassama in Douala metropolis...
June 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29904244/treatment-of-helicobacter-pylori-infection-in-atrophic-gastritis
#7
REVIEW
Edith Lahner, Marilia Carabotti, Bruno Annibale
Helicobacter pylori (Hp) is a major human pathogen causing chronic, progressive gastric mucosal damage and is linked to gastric atrophy and cancer. Hp-positive individuals constitute the major reservoir for transmission of infection. There is no ideal treatment for Hp. Hp infection is not cured by a single antibiotic, and sometimes, a combined treatment with three or more antibiotics is ineffective. Atrophic gastritis (AG) is a chronic disease whose main features are atrophy and/or intestinal metaplasia of the gastric glands, which arise from long-standing Hp infection...
June 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29889263/update-version-of-the-japanese-guidelines-for-gastric-cancer-screening
#8
Chisato Hamashima
Background: Although the incidence and mortality of gastric cancer have gradually decreased, its burden remains in East Asian countries. Gastric cancer screening has been performed in Japan since 1983, and the introduction of new screening techniques has been eagerly anticipated. Objective: To promote evidence-based screening, the Japanese guidelines for gastric cancer screening have been revised based on the new studies. Methods: The guidelines for gastric cancer screening have been developed according to a previously established method...
June 8, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29889002/accuracy-of-two-plasma-antibody-tests-and-faecal-antigen-test-for-non-invasive-detection-of-h-pylori-in-middle-aged-caucasian-general-population-sample
#9
Sabine Skrebinska, Ilva Daugule, Daiga Santare, Sergejs Isajevs, Inta Liepniece-Karele, Dace Rudzite, Ilze Kikuste, Aigars Vanags, Ivars Tolmanis, Juris Atstupens, Jin Young Park, Rolando Herrero, Marcis Leja
OBJECTIVE: The aim of the study was to assess the accuracy of two plasma Helicobacter pylori (H. pylori) antibody test-systems and a stool antigen test (SAT) system in a general population sample in Latvia. MATERIALS AND METHODS: Blood and faecal samples were analysed in healthy individuals (40-64 years), referred for upper gastrointestinal endoscopy according to pilot study protocol within a population-based study investigating gastric cancer prevention strategies (GISTAR pilot study)...
June 11, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29886081/gastric-cancer-french-intergroup-clinical-practice-guidelines-for-diagnosis-treatments-and-follow-up-snfge-ffcd-gercor-unicancer-sfcd-sfed-sfro
#10
REVIEW
Aziz Zaanan, Olivier Bouché, Leonor Benhaim, Bruno Buecher, Nicolas Chapelle, Olivier Dubreuil, Nadim Fares, Victoire Granger, Christine Lefort, Johan Gagniere, Julie Meilleroux, Anne-Sophie Baumann, Veronique Vendrely, Michel Ducreux, Pierre Michel
INTRODUCTION: This document is a summary of the French Intergroup guidelines regarding the management of gastric cancer published in October 2016, available on the website of the French Society of Gastroenterology (SNFGE) (www.tncd.org), updated in October 2017. METHODS: This collaborative work was realized under the auspices of several French medical societies involved in management of gastric cancer. Recommendations are graded in three categories (A-C), according to the amount of evidence found in the literature until July 2017...
June 6, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29882764/molecular-and-pathological-features-of-gastric-cancer-in-lynch-syndrome-and-familial-adenomatous-polyposis
#11
Mara Fornasarig, Raffaella Magris, Valli De Re, Ettore Bidoli, Vincenzo Canzonieri, Stefania Maiero, Alessandra Viel, Renato Cannizzaro
Lynch syndrome (LS) and familial adenomatous polyposis (FAP) are autosomal dominant hereditary diseases caused by germline mutations leading to the development of colorectal cancer. Moreover, these mutations result in the development of a spectrum of different tumors, including gastric cancers (GCs). Since the clinical characteristics of GCs associated with LS and FAP are not well known, we investigated clinical and molecular features of GCs occurring in patients with LS and FAP attending our Institution. The Hereditary Tumor Registry was established in 1994 at the Department of Oncologic Gastroenterology, CRO Aviano National Cancer Institute, Italy...
June 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29882322/new-observations-regarding-helicobacter-pylori-and-gastric-cancer-in-mongolia
#12
Boldbaatar Gantuya, Dashdorj Bolor, Khasag Oyuntsetseg, Yansan Erdene-Ochir, Ruvjir Sanduijav, Duger Davaadorj, Tegshee Tserentogtokh, Dashdorj Azzaya, Tomohisa Uchida, Takeshi Matsuhisa, Yoshio Yamaoka
BACKGROUND: The incidence and mortality of gastric cancer in Mongolia is among the highest in the world. METHODS: This was a case-control study in which upper gastrointestinal endoscopy, gastric histology, Helicobacter pylori testing, and risk factor questionnaires were obtained. Histologic subtypes were determined by Lauren's classification. RESULTS: We enrolled 45 gastric cancer and 108 non-gastric cancer patients. Gastric cancers were located in upper part of stomach in 53...
June 8, 2018: Helicobacter
https://www.readbyqxmd.com/read/29880208/prevalence-of-multiple-infections-and-the-risk-of-gastric-adenocarcinoma-development-at-earlier-age
#13
Sadegh Fattahi, Novin Nikbakhsh, Hassan Taheri, Elham Ghadami, Mohadeseh Kosari-Monfared, Galia Amirbozorgi, Mohsen Asouri, Maryam Pilehchian-Langroudi, Mohammad Ranaee, Ali Akbar Samadani, Mahdi Paryan, Haleh Akhavan-Niaki
Helicobacter pylori and Epstein-Barr virus are well established infections for gastric cancer development. However, the role of cytomegalovirus alone or in combination with other infections is unclear. In this case-control study, the prevalence of different infections was evaluated, and their frequency was compared with clinicopathologic features among gastric cancer patients and normal volunteers from 2012 to 2017. Approximately two-thirds (61.9%) of the gastric cancer patients had at least 1 viral infection, while viral infection prevalence in normal volunteers was only 4...
May 11, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29876742/helicobacter-pylori-is-associated-with-increased-risk-of-serrated-colonic-polyps-analysis-of-serrated-polyp-risk-factors
#14
Anand Kumar, Mimi Kim, Dana J Lukin
BACKGROUND: Sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA) are recognized precursors of colorectal cancer, but their risk factors are not well established. We investigated the association between Helicobacter pylori infection (HPI) and the development of SSA and TSA. METHODS: Retrospective data were collected on patients aged ≥ 18 years that underwent colonoscopy with biopsy between 2006 and 2016. Based on histology, patients were classified into three groups: those with SSA and/or TSA, (serrated neoplasia group, SN); conventional adenomas only (CA); and with no polyps (NP)...
June 7, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29872586/gastric-carcinoma-in-a-patient-with-chronic-lymphocytic-leukemia-coincidence-or-consequence
#15
Mayank Mangal, Sundaramurthi Sudharsanan, T P Elamurugan, Sadasivan Jagdish
Chronic lymphocytic leukemia (CLL) is a neoplasm of mature B-cells of unknown etiology. There is a site-specific increased incidence of second malignancy in patients with CLL. Leukemia and cancer can thus occur in the same patient either simultaneously or sequentially. We present a case of gastric adenocarcinoma in a patient with chronic lymphocytic leukemia. A 47-year old female presented with a history of abdominal pain for one year, along with nausea and vomiting for two months. On examination, she was pale and had generalized lymphadenopathy...
April 2, 2018: Curēus
https://www.readbyqxmd.com/read/29872276/estimation-of-population-based-utility-weights-for-gastric-cancer-related-health-states
#16
Hyeon-Jeong Lee, Minsu Ock, Kyu-Pyo Kim, Min-Woo Jo
Background: This study aimed to generate utility weights of gastric cancer-related health states from the perspective of the Korean general population. Methods: The Korean adults (age ≥19 years) included in the study were sampled using multistage quota sampling methods stratified by sex, age, and education level. Nine scenarios for hypothetical gastric cancer-related health states were developed and reviewed. After consenting to participate, the subjects were surveyed by trained interviewers using a computer-assisted personal interview method...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29870997/usefulness-of-demarcation-of-differentiated-type-early-gastric-cancers-after-helicobacter-pylori-eradication-by-magnifying-endoscopy-with-narrow-band-imaging
#17
Yoichi Akazawa, Hiroya Ueyama, Takashi Yao, Hiroyuki Komori, Tsutomu Takeda, Kohei Matsumoto, Kenshi Matsumoto, Daisuke Asaoka, Mariko Hojo, Sumio Watanabe, Akihito Nagahara
BACKGROUND/AIMS: Early gastric cancer after Helicobacter pylori (Hp) eradication is difficult to demarcate. We used the vessel plus surface classification system (VSCS) to determine whether magnifying endoscopy with narrow-band imaging (ME-NBI) could demarcate differentiated-type early gastric cancers after Hp eradication, and to identify causes of an unclear demarcation line (DL). METHODS: Among 100 lesions of differentiated-type early gastric cancer resected endoscopically, 34 lesions in the Hp-eradicated group and 66 in the Hp-infected group were retrospectively compared...
June 5, 2018: Digestion
https://www.readbyqxmd.com/read/29866802/a-non-catalytic-antioxidant-role-for-helicobacter-pylori-urease
#18
Alan A Schmalstig, Stéphane L Benoit, Sandeep K Misra, Joshua S Sharp, Robert J Maier
The well-studied catalytic role of urease, the Ni-dependent conversion of urea into carbon dioxide and ammonia, has been shown to protect Helicobacter pylori against the low pH environment of the stomach lumen. We hypothesized that the abundantly expressed urease protein can play another, non-catalytic role in combating oxidative stress via Met-residue mediated quenching of harmful oxidants. Three catalytically inactive urease mutant strains were constructed by single substitutions of Ni binding residues. The mutant versions synthesize normal levels of urease and the altered versions retain all methionine residues...
June 4, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29864542/intramolecular-energies-of-the-cytotoxic-protein-caga-of-helicobacter-pylori-as-a-possible-descriptor-of-strains-pathogenicity-level
#19
Diana F Rojas-Rengifo, Maria Camila Alvarez-Silva, Cindy P Ulloa-Guerrero, Vanessa Lucía Nuñez-Velez, Maria Del Pilar Delgado, Sonia Milena Aguilera, Harold Castro, Carlos Alberto Jaramillo, Andrés Fernando González Barrios
The Helicobacter pylori cytotoxin-associated gene A (CagA) is known for causing gastroduodenal diseases, such as atrophic gastritis and peptic ulcerations. Furthermore Helicobacter pylori CagA positive strains has been reported as one of the main risk factors for gastric cancer (Parsonnet et al., 1997). Structural variations in the CagA structure can alter its affinity with the host proteins, inducing differences in the pathogenicity of H. pylori. CagA N-terminal region is characterized for be conserved among all H...
May 25, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29858229/-helicobacter-pylori-adhesin-hopq-disrupts-trans-dimerization-in-human-ceacams
#20
Kristof Moonens, Youssef Hamway, Matthias Neddermann, Marc Reschke, Nicole Tegtmeyer, Tobias Kruse, Robert Kammerer, Raquel Mejías-Luque, Bernhard B Singer, Steffen Backert, Markus Gerhard, Han Remaut
The human gastric pathogen Helicobacter pylori is a major causative agent of gastritis, peptic ulcer disease, and gastric cancer. As part of its adhesive lifestyle, the bacterium targets members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family by the conserved outer membrane adhesin HopQ. The HopQ-CEACAM1 interaction is associated with inflammatory responses and enables the intracellular delivery and phosphorylation of the CagA oncoprotein via a yet unknown mechanism. Here, we generated crystal structures of HopQ isotypes I and II bound to the N-terminal domain of human CEACAM1 (C1ND) and elucidated the structural basis of H...
June 1, 2018: EMBO Journal
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