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Helicobacter pylori and gastric cancer

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https://www.readbyqxmd.com/read/29675003/role-of-micrornas-and-exosomes-in-helicobacter-pylori-and-epstein-barr-virus-associated-gastric-cancers
#1
REVIEW
Iva Polakovicova, Sofia Jerez, Ignacio A Wichmann, Alejandra Sandoval-Bórquez, Nicolás Carrasco-Véliz, Alejandro H Corvalán
Emerging evidence suggests that chronic inflammation caused by pathogen infection is connected to the development of various types of cancer. It is estimated that up to 20% of all cancer deaths is linked to infections and inflammation. In gastric cancer, such triggers can be infection of the gastric epithelium by either Helicobacter pylori ( H. pylori ), a bacterium present in half of the world population; or by Epstein-Barr virus (EBV), a double-stranded DNA virus which has recently been associated with gastric cancer...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29672549/tumor-development-in-japanese-patients-with-lynch-syndrome
#2
Chiaki Saita, Tatsuro Yamaguchi, Shin-Ichiro Horiguchi, Rin Yamada, Misato Takao, Takeru Iijima, Rika Wakaume, Tomoyuki Aruga, Taku Tabata, Koichi Koizumi
BACKGROUND: Lynch syndrome (LS) patients have a high risk of developing various tumors. This study aimed to clarify the characteristics of tumors developing in LS patients. METHODS: This is a retrospective review of 55 LS patients treated at Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital. RESULTS: The median age at the diagnosis of the first malignant tumor and first LS-related tumor was 44 (range, 19-65) and 44 (range, 24-66) years, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29672300/clinical-significance-of-reddish-depressed-lesions-observed-in-the-gastric-mucosa-after-helicobacter-pylori-eradication
#3
Takahiro Kotachi, Masanori Ito, Tomoyuki Boda, Mariko Kiso, Kazuhiko Masuda, Kosaku Hata, Toru Kawamura, Yoji Sanomura, Masaharu Yoshihara, Shinji Tanaka, Kazuaki Chayama
BACKGROUND AND AIM: Reddish depressed lesions (RDLs) frequently observed in patients following Helicobacter pylori eradication are indistinguishable from gastric cancer. We examined the clinical and histological feature of RDLs and its relevant endoscopic diagnosis including magnifying narrow-band imaging (M-NBI). METHODS: We enrolled 301 consecutive patients with H. pylori eradication who underwent endoscopy using white light imaging (WLI). We examined the prevalence and host factors contributing to the presence of RDLs...
April 19, 2018: Digestion
https://www.readbyqxmd.com/read/29671784/epidemiology-of-helicobacter-pylori-and-caga-positive-infections-and-global-variations-in-gastric-cancer
#4
REVIEW
Jin Young Park, David Forman, Langgeng Agung Waskito, Yoshio Yamaoka, Jean E Crabtree
Gastric cancer is a major health burden and is the fifth most common malignancy and the third most common cause of death from cancer worldwide. Development of gastric cancer involves several aspects, including host genetics, environmental factors, and Helicobacter pylori infection. There is increasing evidence from epidemiological studies of the association of H. pylori infection and specific virulence factors with gastric cancer. Studies in animal models indicate H. pylori is a primary factor in the development of gastric cancer...
April 19, 2018: Toxins
https://www.readbyqxmd.com/read/29670922/clinicopathological-features-and-increased-expression-of-toll-like-receptor-4-of-gastric-cardia-cancer-in-a-high-risk-chinese-population
#5
Guangcan Chen, Muming Xu, Jingyao Chen, Liangli Hong, Wenting Lin, Shukun Zhao, Guohong Zhang, Guo Dan, Shuhui Liu
The incidence of gastric cardia cancer (GCC) is high in China. However, the clinicopathological characteristics and the carcinogenesis of GCC are unclear. Toll-like receptor 4 (TLR4) is an important innate immunity receptor and has a role in non-GCC (NGCC). We compared the clinicopathological characteristics of GCC patients from a high-risk area in China to esophageal cancer (EC) patients. Immunohistochemistry for TLR4 was performed in 201 histological samples of normal gastric cardia mucosa ( n = 11), gastric cardia inflammation ( n = 87), and GCC ( n = 103)...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29668771/ivth-brazilian-consensus-conference-on-helicobacter-pylori-infection
#6
Luiz Gonzaga Vaz Coelho, James Ramalho Marinho, Robert Genta, Laercio Tenório Ribeiro, Maria do Carmo Friche Passos, Schlioma Zaterka, Paulo Pimentel Assumpção, Alfredo José A Barbosa, Ricardo Barbuti, Lucia Libanês Braga, Helenice Breyer, Aloisio Carvalhaes, Décio Chinzon, Marcelo Cury, Gerson Domingues, Jorge Luiz Jorge, Ismael Maguilnik, Frederico Passos Marinho, Joaquim Prado de Moraes-Filho
Significant progress has been obtained since the III Brazilian Consensus Conference on H. pylori infection held in 2012, in Bento Gonçalves, Brazil, and justify a fourth meeting to establish updated guidelines on the current management of H. pylori infection. Therefore, the Núcleo Brasileiro para Estudo do Helicobacter pylori e Microbiota (NBEHPM), association linked to Brazilian Federation of Gastroenterology (FBG) held its fourth meeting again in Bento Gonçalves, RS, Brazil, on August 25-27, 2017. Twenty-six delegates, including gastroenterologists, endoscopists, and pathologists from the five regions of Brazil as well as one international guest from the United States, participated in the meeting...
April 16, 2018: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/29668600/chilean-gastric-cancer-task-force-a-study-protocol-to-obtain-a-clinical-and-molecular-classification-of-a-cohort-of-gastric-cancer-patients
#7
Gareth I Owen, Mauricio P Pinto, Ignacio N Retamal, María F Fernádez, Betzabe Cisternas, Sebastian Mondaca, Cesar Sanchez, Hector Galindo, Bruno Nervi, Carolina Ibañez, Francisco Acevedo, Jorge Madrid, José Peña, Maria Loreto Bravo, Maria Jose Maturana, Miguel Cordova-Delgado, Diego Romero, Nathaly de la Jara, Javiera Torres, Maria Rodriguez-Fernandez, Manuel Espinoza, Carlos Balmaceda, Matías Freire, Valentina Gárate-Calderón, Fernando Crovari, Paula Jimenez-Fonseca, Alberto Carmona-Bayonas, Ariel Zwenger, Ricardo Armisen, Alejandro H Corvalan, Marcelo Garrido
Gastric cancer (GC) is the world's second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >3000 deaths/y. Clinical outcomes and response to "one size fits all" therapies are highly heterogeneous and thus a better stratification of patients may aid cancer treatment and response...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29666402/expression-of-kk-lc-1-a-cancer-testis-antigen-at-non-tumour-sites-of-the-stomach-carrying-a-tumour
#8
Takashi Fukuyama, Nobue Futawatari, Rui Yamamura, Taiga Yamazaki, Yoshinobu Ichiki, Akira Ema, Hideki Ushiku, Yatsushi Nishi, Yoshihito Takahashi, Toshikazu Otsuka, Hitoshi Yamazaki, Wasaburo Koizumi, Kosei Yasumoto, Noritada Kobayashi
Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen (CTA) and predominant target for cancer immunotherapy. Our previous study indicated that KK-LC-1 was expressed in 82% of gastric cancers, and also in 79% of early stage of gastric cancers, with a correlation to Helicobacter pylori (H. pylori) infection. In addition, we found that KK-LC-1 was occasionally expressed at non-tumour sites of stomachs carrying tumours. Here, we investigated the characteristics of KK-LC-1 expression at non-tumour sites and the clinical utility of these phenomena...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665437/multiplex-serology-of-helicobacter-pylori-antigens-in-detection-of-current-infection-and-atrophic-gastritis-a-simple-and-cost-efficient-method
#9
Ebrahim Shafaie, Samaneh Saberi, Maryam Esmaeili, Zeynab Karimi, Saeed Najafi, Mohammad Tashakoripoor, Afshin Abdirad, Mahmoud Eshagh Hosseini, Mohammad Ali Mohagheghi, Vahid Khalaj, Marjan Mohammadi
INTRODUCTION: Helicobacter pylori express a large array of antigens, each of which is duly responsible for successful colonization and pathogenesis. Here, we have studied host serum antibody responses to four of its immunodominant antigens in association with the infection status and the resulting clinical outcomes. METHODS: For this purpose, four individual H. pylori proteins (UreB, CagA, Tip-α and HP0175) were produced in recombinant forms. Serum antibody responses of 246 (75 GC and 171 NUD) patients, against the above antigens, were evaluated by multiplex immunoblotting...
April 14, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29662291/punctual-mutations-in-23s-rrna-gene-of-clarithromycin-resistant-helicobacter-pylori-in-colombian-populations
#10
Andrés Jenuer Matta, Diana Carolina Zambrano, Alvaro Jairo Pazos
AIM: To characterize punctual mutations in 23S rRNA gene of clarithromycin-resistant Helicobacter pylori ( H. pylori ) and determine their association with therapeutic failure. METHODS: PCR products of 23S rRNA gene V domain of 74 H. pylori isolates; 34 resistant to clarithromycin (29 from a low-risk gastric cancer (GC) population: Tumaco-Colombia, and 5 from a high-risk population: Tuquerres-Colombia) and 40 from a susceptible population (28 from Tumaco and 12 from Túquerres) were sequenced using capillary electrophoresis...
April 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29659170/association-of-peripheral-blood-leukocyte-kibra-methylation-with-gastric-cancer-risk-a-case-control-study
#11
Yan Zhang, Haibo Zhou, Hongxu Sun, Jie Chen, Di Huang, Xu Han, Xiyun Ren, Shangqun Lin, Qing Fan, Wenjing Tian, Yashuang Zhao
KIBRA was reported to be involved in various types of cancer and can be detected in blood. The purpose of this study was to investigate the relationship between the status of KIBRA methylation in peripheral blood leukocytes and gastric cancer (GC) risk. A case-control study was carried out to evaluate the association of blood cell-derived KIBRA methylation with the risk of GC using methylation-sensitive high-resolution melting analysis. A total of 393 cases and 393 controls were detected, respectively. Compared with the subjects in the KIBRA negative methylation (NM) group, positive methylation (PM) subjects exhibited a 1...
April 16, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29658052/reduced-%C3%AE-glcnac-glycosylation-on-gastric-gland-mucin-is-a-biomarker-of-malignant-potential-for-gastric-cancer-barrett-s-adenocarcinoma-and-pancreatic-cancer
#12
REVIEW
Kazuhiro Yamanoi, Jun Nakayama
Gastric gland mucin secreted from pyloric gland cells, mucous neck cells, and cardiac gland cells of the gastric mucosa harbors unique O-glycans carrying terminal α1,4-linked N-acetylglucosamine residues (αGlcNAc), which are primarily attached to the scaffold mucin core protein MUC6. αGlcNAc acts as an antibiotic against Helicobacter pylori (H. pylori), a microbe causing gastric cancer. In addition, mice deficient in A4gnt, which encodes the enzyme α1,4-N-acetylglucosaminyltransferase (α4GnT) that catalyzes αGlcNAc biosynthesis, spontaneously develop gastric differentiated-type adenocarcinoma, even if not infected by H...
April 16, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29656498/helicobacter-pylori-infection-induced-h3ser10-phosphorylation-in-stepwise-gastric-carcinogenesis-and-its-clinical-implications
#13
Tao-Tao Yang, Na Cao, Hai-Hui Zhang, Jian-Bo Wei, Xiao-Xia Song, Dong-Min Yi, Shuai-Heng Chao, Li-Da Zhang, Ling-Fei Kong, Shuang-Yin Han, Yu-Xiu Yang, Song-Ze Ding
BACKGROUND: Our previous works have demonstrated that Helicobacter pylori (Hp) infection can alter histone H3 serine 10 phosphorylation status in gastric epithelial cells. However, whether Helicobacter pylori-induced histone H3 serine 10 phosphorylation participates in gastric carcinogenesis is unknown. We investigate the expression of histone H3 serine 10 phosphorylation in various stages of gastric disease and explore its clinical implication. MATERIALS AND METHODS: Stomach biopsy samples from 129 patients were collected and stained with histone H3 serine 10 phosphorylation, Ki67, and Helicobacter pylori by immunohistochemistry staining, expressed as labeling index...
April 15, 2018: Helicobacter
https://www.readbyqxmd.com/read/29627231/status-of-vaccine-research-and-development-for-helicobacter-pylori
#14
Philip Sutton, Joanne M Boag
Gastric adenocarcinoma is globally the third leading cause of death due to malignancy, with the bulk of this disease burden being suffered by low and middle income countries (LMIC), especially in Asia. The majority of these cancers develop as a result of a chronic gastritis that arises in response to infection with the stomach-dwelling bacterium, Helicobacter pylori. A vaccine against this pathogen would therefore be a powerful tool for preventing gastric adenocarcinoma. However, notwithstanding a proof-of-concept that vaccination can protect children from acquisition of H...
April 4, 2018: Vaccine
https://www.readbyqxmd.com/read/29625086/tr1-responses-are-elevated-in-asymptomatic-h-pylori-infected-individuals-and-are-functionally-impaired-in-h-pylori-gastric-cancer-patients
#15
Zongchang Song, Tongxia Zhang, Guang Li, Ying Tang, Yan Luo, Genhua Yu
Gastric cancer is one of the most lethal malignancies worldwide. Chronic Helicobacter pylori (H. pylori) infection can induce an inflammatory response that promotes atrophic gastritis, a preceding event to cancer development. The type 1 regulatory T (Tr1) cells have recently emerged as a critical participant in maintaining self-tolerance. In this study, we examined Tr1 cells in H. pylori infection and gastric cancer development. While H. pylori-uninfected (uninfected) subjects presented low Tr1 frequency in the peripheral blood, H...
April 3, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29621300/characteristics-of-non-cardia-gastric-cancer-with-a-high-serum-anti-helicobacter-pylori-igg-titer-and-its-association-with-diffuse-type-histology
#16
Eun Jeong Gong, Ji Young Lee, Suh Eun Bae, Young Soo Park, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Woo Jin Jeong, Gab Jin Cheon, Jeong Hwan Yook, Byung Sik Kim
BACKGROUND: Data on implications of a high positive titer of serum anti-Helicobacter pylori antibody on gastric cancer (GC) is limited. This study aimed to investigate the characteristics of GC with a high serum anti-H. pylori IgG (Hp-IgG) titer, and its association with diffuse-type GC. METHODS: We analyzed clinical and histological characteristics of 917 non-cardia GC patients who underwent gastrectomy. H. pylori infection was determined serologically by measuring Hp-IgG titer with immunoassay...
2018: PloS One
https://www.readbyqxmd.com/read/29611052/gastric-cancer-in-india-epidemiology-and-standard-of-treatment
#17
Chandramohan Servarayan Murugesan, Kanagavel Manickavasagam, Apsara Chandramohan, Abishai Jebaraj, Abdul Rehman Abdul Jameel, Mayank Shikar Jain, Jayanthi Venkataraman
India has a low incidence of gastric cancer. It ranks among the top five most common cancers. Regional diversity of incidence is of importance. It is the second most common cause of cancer related deaths among Indian men and women in the age between 15 and 44. Helicobacter pylori carcinogenesis is low in India. Advanced stage at presentation is a cause of concern. Basic and clinical research in India reveals a globally comparable standard of care and outcome. The large population, sociodemographic profile and challenges in health expenditure, however, remain a major challenge for health care policy managers...
April 2, 2018: Updates in Surgery
https://www.readbyqxmd.com/read/29606921/overview-of-current-concepts-in-gastric-intestinal-metaplasia-and-gastric-cancer
#18
David S Jencks, Jason D Adam, Marie L Borum, Joyce M Koh, Sindu Stephen, David B Doman
Gastric intestinal metaplasia is a precancerous change of the mucosa of the stomach with intestinal epithelium, and is associated with an increased risk of dysplasia and cancer. The pathogenesis to gastric cancer is proposed by the Correa hypothesis as the transition from normal gastric epithelium to invasive cancer via inflammation followed by intramucosal cancer and invasion. Multiple risk factors have been associated with the development of gastric intestinal metaplasia interplay, including Helicobacter pylori infection and associated genomics, host genetic factors, environmental milieu, rheumatologic disorders, diet, and intestinal microbiota...
February 2018: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29605555/randomized-controlled-trial-ppi-based-triple-therapy-containing-metronidazole-versus-clarithromycin-as-first-line-treatment-for-helicobacter-pylori-in-adolescents-and-young-adults-in-japan
#19
Katushiro Mabe, Masumi Okuda, Shogo Kikuchi, Kenji Amagai, Rie Yoshimura, Mototsugu Kato, Naoya Sakamoto, Masahiro Asaka
BACKGROUND/AIMS: Treating Helicobacter pylori infection in young people is effective for preventing gastric cancer. This study compares the efficacy of triple therapies in adolescents and young adults in Japan. METHODS: This multicenter, randomized trial was conducted between February 2012 and March 2015. Infected participants were stratified into adolescents (13-19 years) and young adults (20-39 years). They were randomly assigned to a clarithromycin based (PAC) or metronidazole based (PAM) triple therapy for 1 week...
March 28, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29604247/involvement-of-micrornas-mmps-e-cadherin-in-the-migration-and-invasion-of-gastric-cancer-cells-infected-with-helicobacter-pylori
#20
Yongmei Yang, Xiaohui Li, Jie Du, Youcong Yin, Yuanjian Li
It has been found that Helicobacter pylori (H. pylori)is not only the main cause of gastric cancer, but also closely related to its metastasis. E-cadherin cleavage induced by matrix metalloproteinases (MMPs) plays an important role in the tumor metastasis. In the present study, we investigated the role of microRNAs-MMPs-E-cadherin in migration and invasion of gastric cancer cells treated with H. pylori. The results showed that H. pylori induced migration and invasion of SGC-7901 cells with a down-regulation of E-cadherin expression, which were abolished by MMPs knock down, E-cadherin overexpression, mimics of miR128 and miR148a...
March 28, 2018: Experimental Cell Research
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