Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Songming Li, Qijie Luo, Shirui Chen, Zehua Jia, Tielong Wang, Xinyu Yu, Wenjing Wang, YuyiZhang, Jiaxing Zhu, Feiwen Deng, Qiang Sun, Zhiyong Guo, Xiaoshun He
BACKGROUND AND AIMS: Increasing utilization of extended criteria donor leads to an increasing rate of early allograft failure after liver transplantation. However, consensus of definition of early allograft failure is lacking. METHODS: A retrospective, multicenter study was performed to validate the Liver Graft Assessment Following Transplantation (L-GrAFT) risk model in a Chinese cohort of 942 adult patients undergoing primary liver transplantation at three Chinese centers...
January 28, 2024: Journal of Clinical and Translational Hepatology
#22
JOURNAL ARTICLE
Natalie Tapaskar, Brian Wayda, Darren Malinoski, Helen Luikart, Tahnee Groat, John Nguyen, John Belcher, Javier Nieto, Nikole Neidlinger, Ahmad Salehi, P J Geraghty, Bruce Nicely, Martin Jendrisak, Thomas Pearson, R Patrick Wood, Shiqi Zhang, Yingjie Weng, Jonathan Zaroff, Kiran K Khush
BACKGROUND: Potential organ donors often exhibit abnormalities on electrocardiograms (ECGs) after brain death, but the physiological and prognostic significance of such abnormalities is unknown. OBJECTIVES: This study sought to characterize the prevalence of ECG abnormalities in a nationwide cohort of potential cardiac donors and their associations with cardiac dysfunction, use for heart transplantation (HT), and recipient outcomes. METHODS: The Donor Heart Study enrolled 4,333 potential cardiac organ donors at 8 organ procurement organizations across the United States from 2015 to 2020...
January 6, 2024: JACC. Heart Failure
#23
JOURNAL ARTICLE
Chase J Wehrle, Roma Raj, Marianna Maspero, Sangeeta Satish, Bijan Eghtesad, Alejandro Pita, Jaekeun Kim, Mazhar Khalil, Esteban Calderon, Danny Orabi, Bobby Zervos, Jamak Modaresi Esfeh, Maureen Whitsett Linganna, Teresa Diago-Uso, Masato Fujiki, Cristiano Quintini, Choon David Kwon, Charles Miller, Antonio Pinna, Federico Aucejo, Koji Hashimoto, Andrea Schlegel
BACKGROUND: Liver transplantation (LT) is a well-established treatment for hepatocellular carcinoma (HCC), but there are ongoing debates regarding outcomes and selection. This study examines the experience of LT for HCC at a high-volume center. METHODS: A prospectively maintained database was used to identify HCC patients undergoing LT from 2000-2020 with>3 years follow-up. Data was obtained from the center database and electronic medical records. The Metroticket 2...
January 22, 2024: International Journal of Surgery
#24
JOURNAL ARTICLE
Perin Kothari, Larissa Miyachi Kiwakyou, Brandon A Guenthart, Matthew Vanneman
As the demand for heart allografts for transplantation continues to rise, ex vivo organ perfusion strategies are playing an increasingly important role in the preservation of organs from donation after circulatory death and extended-criteria donors. One such method uses the Organ Care System (TransMedics, Andover, MA). Traditionally, this technique of preservation requires 2 periods of warm ischemia and subsequent cardioplegic arrest. In a novel surgical technique pioneered at the authors' institution, heart allograft implantation no longer requires a second cardioplegic arrest...
December 23, 2023: Journal of Cardiothoracic and Vascular Anesthesia
#25
JOURNAL ARTICLE
Jacob Marthinsen Seefeldt, Yaara Libai, Katrine Berg, Nichlas Riise Jespersen, Thomas Ravn Lassen, Frederik Flyvholm Dalsgaard, Pia Ryhammer, Michael Pedersen, Lars Bo Ilkjaer, Michiel A Hu, Michiel E Erasmus, Roni R Nielsen, Hans Erik Bøtker, Oren Caspi, Hans Eiskjær, Niels Moeslund
Normothermic regional perfusion (NRP) allows assessment of therapeutic interventions prior to donation after circulatory death transplantation. Sodium-3-hydroxybutyrate (3-OHB) increases cardiac output in heart failure patients and diminishes ischemia-reperfusion injury, presumably by improving mitochondrial metabolism. We investigated effects of 3-OHB on cardiac and mitochondrial function in transplanted hearts and in cardiac organoids. Donor pigs (n = 14) underwent circulatory death followed by NRP...
January 8, 2024: Scientific Reports
#26
JOURNAL ARTICLE
Nandan K Mondal, Shiyi Li, Abdussalam E Elsenousi, Aladdein Mattar, Katherine V Nordick, Harveen K Lamba, Camila Hochman-Mendez, Todd K Rosengart, Kenneth K Liao
This study investigated cardiac stress and mitochondrial oxidative phosphorylation (OxPhos) in human donation after circulatory death (DCD) hearts regarding warm ischemic time (WIT) and subsequent cold storage and compared them with that of human brain death donor (DBD) hearts. A total of 24 human hearts were procured for the research study-6 in the DBD group and 18 in the DCD group. DCD group was divided into three groups ( n = 6) based on different WITs (20, 40, and 60 min). All hearts received del Nido cardioplegia before being placed in normal saline cold storage for 6 h...
March 1, 2024: American Journal of Physiology. Heart and Circulatory Physiology
#27
JOURNAL ARTICLE
Assessing Liver Viability: Insights From Mitochondrial Bioenergetics in Ischemia-Reperfusion Injury.
Chinedu Nwaduru, Emma Baker, Michelle Buff, Motaz Selim, Leo Aviles Ovalle, Talia B Baker, Michael A Zimmerman
Orthotopic liver transplantation remains the definitive treatment for patients with end-stage liver disease. Unfortunately, the increasing demand for donor livers and the limited supply of viable organs have both led to a critical need for innovative strategies to expand the pool of transplantable organs. The mitochondrion, central to hepatic cellular function, plays a pivotal role in hepatic ischemic injury, with impaired mitochondrial function and oxidative stress leading to cell death. Mitochondrial protection strategies have shown promise in mitigating IRI and resuscitating marginal organs for transplant...
January 2, 2024: Transplantation Proceedings
#28
JOURNAL ARTICLE
Michael T Cain, Sarah Y Park, Michal Schäfer, Emily Hay-Arthur, George A Justison, Qui Peng Zhan, David Campbell, John D Mitchell, Simran K Randhawa, Robert A Meguid, Elizabeth A David, T Brett Reece, Joseph C Cleveland, Jordan R H Hoffman
OBJECTIVE: Donation after circulatory death (DCD) procurement and transplantation after thoracoabdominal normothermic regional perfusion (TA-NRP) remains a novel technique to improve cardiac and hepatic allograft preservation but may be complicated by lung allograft pulmonary edema. We present a single-center series on early implementation of a lung-protective protocol with strategies to mitigate posttransplant pulmonary edema in DCD lung allografts after TA-NRP procurement. METHODS: Data from all lung transplantations performed using a TA-NRP procurement strategy from October 2022 to April 2023 are presented...
December 2023: JTCVS techniques
#29
REVIEW
Savitri Fedson
PURPOSE OF REVIEW: The use of cardiac transplantation following circulatory death (DCD) has been limited worldwide. Concerns about cardiac function after warm ischemia and the potential for decreased graft function have been important considerations in this hesitancy. In addition, ethical and legal questions about the two widely used organ procurement methods have led to discussions and public education in many countries. RECENT FINDINGS: Publication of a US randomized trial of cardiac transplantation following DCD has shown that it is both feasible and has similar short-term outcomes compared with cardiac transplantation following brain death (DBD)...
March 1, 2024: Current Opinion in Cardiology
#30
RANDOMIZED CONTROLLED TRIAL
Glauco A Westphal, Caroline Cabral Robinson, Natalia Elis Giordani, Cassiano Teixeira, Adriane Isabel Rohden, Bruna Dos Passos Gimenes, Cátia Moreira Guterres, Itiana Cardoso Madalena, Luiza Vitelo Andrighetto, Sabrina Souza da Silva, Daiana Barbosa da Silva, Daniel Sganzerla, Alexandre Biasi Cavalcanti, Cristiano Augusto Franke, Fernando Augusto Bozza, Flávia Ribeiro Machado, Joel de Andrade, Luciano Cesar Pontes Azevedo, Silvana Schneider, Bianca Rodrigues Orlando, Cintia Magalhães Carvalho Grion, Fernando Albuerne Bezerra, Fernando Roberto Roman, Francisco Olon Leite, Íris Lima Ferraz Siqueira, João Fernando Piccolo Oliveira, Lúcio Couto de Oliveira, Maria de Fátima Rodrigues Buarque de Melo, Patrícia Berg Gonçalves Pereira Leal, Pedro Carvalho Diniz, Rafael Barbarena Moraes, Daniela Ferreira Salomão Pontes, Josélio Emar Araújo Queiroz, Luciano Serpa Hammes, Maureen O Meade, Regis Goulart Rosa, Maicon Falavigna
IMPORTANCE: The effectiveness of goal-directed care to reduce loss of brain-dead potential donors to cardiac arrest is unclear. OBJECTIVE: To evaluate the effectiveness of an evidence-based, goal-directed checklist in the clinical management of brain-dead potential donors in the intensive care unit (ICU). DESIGN, SETTING, AND PARTICIPANTS: The Donation Network to Optimize Organ Recovery Study (DONORS) was an open-label, parallel-group cluster randomized clinical trial in Brazil...
December 1, 2023: JAMA Network Open
#31
JOURNAL ARTICLE
Jin-Long Gong, Jia Yu, Tie-Long Wang, Xiao-Shun He, Yun-Hua Tang, Xiao-Feng Zhu
BACKGROUND: There is no consensus on the usage of extended criteria donor (ECD) grafts in liver transplantation (LT) for acute-on-chronic liver failure (ACLF) patients. AIM: To summarize the experience of using ECD livers in ACLF-LT. METHODS: A retrospective cohort study was conducted, enrolling patients who underwent LT at the First Affiliated Hospital of Sun Yat-Sen University from January 2015 to November 2021. The patients were divided into ECD and non-ECD groups for analysis...
November 7, 2023: World Journal of Gastroenterology: WJG
#32
JOURNAL ARTICLE
Lauren K Truby, Lydia Coulter Kwee, Dawn E Bowles, Sarah Casalinova, Olga Ilkayeva, Michael J Muehlbauer, Janet L Huebner, Christopher L Holley, Adam D DeVore, Chetan B Patel, Lillian Kang, Michelle Mendiola Pla, Ryan Gross, Robert W McGarrah, Jacob N Schroder, Carmelo A Milano, Svati H Shah
PURPOSE: Cardiac metabolism is altered in heart failure and ischemia-reperfusion injury states. We hypothesized that metabolomic profiling during ex-situ normothermic perfusion before heart transplantation (HT) would lend insight into myocardial substrate utilization and report on subclinical and clinical allograft dysfunction risk. METHODS: Metabolomic profiling was performed on serial samples of ex-situ normothermic perfusate assaying biomarkers of myocardial injury in lactate and cardiac troponin I (TnI) as well as metabolites (66 acylcarnitines, 15 amino acids, non-esterified fatty acids (NEFA), ketones, and 3-hydroxybutyrate)...
December 6, 2023: Journal of Heart and Lung Transplantation
#33
REVIEW
Anne I Dipchand, Steven A Webber
Heart transplantation has become the standard of care for pediatric patients with end-stage heart disease throughout the world. Since the first transplant was performed in 1967, the number of transplants has grown dramatically with 13 449 pediatric heart transplants being reported to The International Society of Heart and Lung Transplant (ISHLT) between January 1992 and June 30, 2018. Outcomes have consistently improved over the last few decades, specifically short-term outcomes. Most recent survival data demonstrate that recipients who survive to 1-year post-transplant have excellent long-term survival with more than 60% of those who were transplanted as infants being alive 25 years later...
February 2024: Pediatric Transplantation
#34
JOURNAL ARTICLE
Masaki Murata, Masayuki Tasaki, Kazuhide Saito, Yuki Nakagawa, Masahiro Ikeda, Masato Akiyama, Naofumi Imai, Ichiei Narita, Kota Takahashi, Yoshihiko Tomita
OBJECTIVES: Regarding the relationship between donor kidney quality and renal graft function after deceased kidney transplantation (KTx) following donation after cardiac death (DCD), the evaluation timing varies depending on the study. Evaluation of histology and changes in long-term renal graft function is limited. METHODS: A retrospective single-center study included 71 recipients who underwent 0-hour biopsy for KTx from DCD. The recipients were divided into two groups to evaluate factors related to renal graft function (study1)...
December 8, 2023: International Journal of Urology: Official Journal of the Japanese Urological Association
#35
JOURNAL ARTICLE
Iga Stryjak, Natalia Warmuzińska, Kamil Łuczykowski, Karol Jaroch, Peter Urbanellis, Markus Selzner, Barbara Bojko
Transplant centers are currently facing a lack of tools to ensure adequate evaluation of the quality of the available organs, as well as a significant shortage of kidney donors. Therefore, efforts are being made to facilitate the effective use of available organs and expand the donor pool, particularly with expanded criteria donors. Fulfilling a need, we aim to present an innovative analytical method based on solid-phase microextraction (SPME) - chemical biopsy. In order to track changes affecting the organ throughout the entire transplant procedure, porcine kidneys were subjected to multiple samplings at various time points...
December 3, 2023: Translational Research: the Journal of Laboratory and Clinical Medicine
#36
REVIEW
Joseph B Lerman, Richa Agarwal, Chetan B Patel, Jeffrey E Keenan, Sarah Casalinova, Carmelo A Milano, Jacob N Schroder, Adam D DeVore
Historically, heart transplantation (HT) has relied on the use of traditional cold storage for donor heart preservation. This organ preservation modality has several limitations, including the risk for ischemic and cold-induced graft injuries that may contribute to primary graft dysfunction and poor post-HT outcomes. In recent years, several novel donor heart preservation modalities have entered clinical practice, including the SherpaPak Cardiac Transport System of controlled hypothermic preservation, and the Transmedics Organ Care System of ex vivo perfusion...
March 2024: JACC. Heart Failure
#37
JOURNAL ARTICLE
Samrat Ray, Chaya Shwaartz, Blayne Amir Sayed, Gonzalo Sapisochin, Anand Ghanekar, Ian McGilvray, Mark Cattral, Leslie Lilly, Nazia Selzner, Cynthia Tsien, Mamatha Bhat, Elmar Jaeckel, Markus Selzner, Trevor W Reichman
BACKGROUND: Advanced donor age paired with donation after cardiac death (DCD) increases the risk of transplantation, precluding widespread use of grafts from such donors worldwide. Our aim was to analyze outcomes of liver transplantation using grafts from older DCD donors and donation after brain death (DBD) donors. METHODS: Patients who underwent liver transplantation using grafts from deceased donors between January 2016 and December 2021 were included in the study...
2023: Canadian Journal of Surgery. Journal Canadien de Chirurgie
#38
JOURNAL ARTICLE
Aarathi Vijayashanker, Varuna Aluvihare, Abid Suddle, Alberto Sanchez-Fueyo, Miriam Cortes Cerisuelo, Hector V Melendez, Wayel Jassem, Krishna V Menon, Nigel Heaton, Andreas Prachalias, Parthi Srinivasan
BACKGROUND: As the world recovers from the aftermath of devastating waves of an outbreak, the ongoing Coronavirus disease 2019 pandemic has presented a unique perspective to the transplantation community of ''organ utilisation'' in liver transplantation, a poorly defined term and ongoing hurdle in this field. To this end, we report the key metrics of transplantation activity from a high-volume liver transplantation centre in the United Kingdom over the past two years. METHODS: Between March 2019 and February 2021, details of donor liver offers received by our centre from National Health Service Blood & Transplant, and of transplantation were reviewed...
February 2023: J Liver Transpl
#39
JOURNAL ARTICLE
Emily Limerick, Jennifer Shmukler, Arlene Sirajuddin, My-Le Nguyen, Neal Jeffries, Vandana Sachdev, Courtney D Fitzhugh
Cardiopulmonary complications account for approximately 40% of deaths in patients with sickle cell disease (SCD). Diffuse myocardial fibrosis, elevated tricuspid regurgitant jet velocity (TRV) and iron overload are all associated with early mortality. While HLA-matched sibling hematopoietic cell transplant (HCT) offers a potential cure, fewer than 20% of patients have a suitable donor. Haploidentical HCT allows for an increased donor pool and has recently demonstrated improved safety and efficacy. Our group has reported improved cardiac morphology via echocardiography at one year after HCT...
November 10, 2023: Transplantation and cellular therapy
#40
JOURNAL ARTICLE
William A Preston, Devon J Pace, Peter J Altshuler, Misung Yi, Haley Kittle, Sage Vincent, Kenneth Andreoni, Adam M Frank, Jaime M Glorioso, Carlo Ramirez, Warren R Maley, Ashesh P Shah, Adam S Bodzin
The recent shortage of University of Wisconsin (UW) solution prompted increased utilization of histidine-tryptophan-ketoglutarate (HTK) solution for liver graft preservation. This contemporary study analyzed deceased donor liver transplant outcomes following preservation with HTK vs. UW. Patients receiving deceased donor liver transplantations between 1/1/2019 and 6/30/2022 were retrospectively identified utilizing the Organ Procurement and Transplant Network database, stratified by preservation with HTK vs...
November 6, 2023: American Journal of Transplantation
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
