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https://www.readbyqxmd.com/read/29754271/reduced-dose-epoch-r-chemotherapy-for-elderly-patients-with-advanced-stage-diffuse-large-b-cell-lymphoma
#1
Wen-Hao Zhang, Gao-Yang Li, Yu-Jie Ma, Zhi-Chao Li, Yang Zhu, Jun Chang, Si-Guo Hao, Rong Tao
The standard treatment in elderly patients with diffuse large B cell lymphoma (DLBCL) has not yet been finely established. We investigated the efficacy and safety of rituximab with a reduced-dose of EPOCH chemotherapy in elderly patients who had advanced DLBCL with high IPI scores. The dose of 70% EPOCH was given to patients aged 75 to 79 years, and dose of 50% to patients aged over 80 years. Thirty-one patients with a median age of 79 years (range 75-86 years) were enrolled. Patients received a median of 6 cycle's chemotherapy...
May 12, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29388195/vaccines-for-preventing-influenza-in-healthy-children
#2
REVIEW
Tom Jefferson, Alessandro Rivetti, Carlo Di Pietrantonj, Vittorio Demicheli
BACKGROUND: The consequences of influenza in children and adults are mainly absenteeism from school and work. However, the risk of complications is greatest in children and people over 65 years of age. This is an update of a review published in 2011. Future updates of this review will be made only when new trials or vaccines become available. Observational data included in previous versions of the review have been retained for historical reasons but have not been updated because of their lack of influence on the review conclusions...
February 1, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29384856/use-of-noncontact-infrared-thermography-to-measure-temperature-in-children-in-a-triage-room
#3
Emel Ataş Berksoy, Özlem Bağ, Selçuk Yazici, Tanju Çelik
We compared the accuracy and utility of 3 infrared (IFR) thermographs fitted with axillary digital thermometers used to measure temperature in febrile and afebrile children admitted to an emergency triage room.A total of 184 febrile and 135 afebrile children presenting to a triage room were consecutively evaluated. Axillary temperature was recorded using a digital electronic thermometer. Simultaneously, IFR skin scans were performed on the forehead, the neck (over the carotid artery), and the nape by the same nurse...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29227817/comparing-granulocyte-colony-stimulating-factor-filgrastim-and-pegfilgrastim-to-its-biosimilars-in-terms-of-efficacy-and-safety-a-meta-analysis-of-randomised-clinical-trials-in-breast-cancer-patients
#4
Edoardo Botteri, Andriy Krendyukov, Giuseppe Curigliano
BACKGROUND: Granulocyte colony-stimulating factors (G-CSFs) are widely used to prevent neutropenia in cancer patients undergoing myelosuppressive chemotherapy. Several biosimilar medicines of G-CSF are now available, with their development involving a step-wise series of comparisons to demonstrate similarity to reference biologics. Randomised clinical trials (RCTs) are considered confirmatory, and for G-CSF biosimilars, patients with breast cancer (BC) undergoing myelosuppressive chemotherapy are the most sensitive population in which to confirm similarity...
January 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29185016/the-radiological-myometrial-appearance-after-cesarean-section-is-it-associated-with-postpartum-complications-and-subsequent-delivery-outcome
#5
Naama R Bogot, Misagv Rottenstreich, Rinad M Nabulsi, Yonatan Turner, Rivka Farkash, Arnon Samueloff, Sorina Grisaru-Granovsky
PURPOSE: To evaluate whether the characteristics of the radiological uterine myometrial discontinuity (RMD) is associated with maternal-neonatal outcomes and post-cesarean section (CS) complications. A secondary aim was to describe the evolution of the CT uterine surgical incision and the related outcome of a subsequent trial of labor after cesarean (TOLAC). METHODS: Single center retrospective cohort study of CT scans was performed within 6 weeks from cesarean delivery...
November 28, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29181611/human-wildlife-interactions-predict-febrile-illness-in-park-landscapes-of-western-uganda
#6
Jonathan Salerno, Noam Ross, Ria Ghai, Michael Mahero, Dominic A Travis, Thomas R Gillespie, Joel Hartter
Fevers of unknown origin complicate treatment and prevention of infectious diseases and are a global health burden. We examined risk factors of self-reported fever-categorized as "malarial" and "nonmalarial"-in households adjacent to national parks across the Ugandan Albertine Rift, a biodiversity and emerging infectious disease hotspot. Statistical models fitted to these data suggest that perceived nonmalarial fevers of unknown origin were associated with more frequent direct contact with wildlife and with increased distance from parks where wildlife habitat is limited to small forest fragments...
December 2017: EcoHealth
https://www.readbyqxmd.com/read/29062193/application-of-radio-frequency-based-digital-thermometer-for-real-time-monitoring-of-dairy-cattle-rectal-temperature
#7
Tridib Debnath, Santanu Bera, Suman Deb, Prasenjit Pal, Nibash Debbarma, Avijit Haldar
AIM: Dairy cattle health monitoring program becomes vital for detecting the febrile conditions to prevent the outbreak of the animal diseases as well as ensuring the fitness of the animals that are directly affecting the health of the consumers. The aim of this study was to validate real-time rectal temperature (RT) data of radio frequency based digital (RFD) thermometer with RT data of mercury bulb (MB) thermometer in dairy cattle. MATERIALS AND METHODS: Two experiments were conducted...
September 2017: Veterinary World
https://www.readbyqxmd.com/read/29057729/-optimal-duration-of-antibiotic-therapy-there-is-no-one-size-fits-all
#8
J Malotaux, W J Wiersinga, S E Geerlings
The increasing use of antibiotics is the main driving force behind the rise of antibiotic resistance. Furthermore, there is a large variation in antibiotic use amongst prescribers. We describe the current duration of antibiotic therapy for common infections in the Netherlands and the new studies we can expect in this field in the years to come. We think that more research is needed to determine the duration of antibiotic therapy on the basis of different patient characteristics. It has, for example, recently been shown that the sex of the patient plays an important role in optimal duration of therapy for febrile urinary tract infections...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29033099/custirsen-ogx-011-combined-with-cabazitaxel-and-prednisone-versus-cabazitaxel-and-prednisone-alone-in-patients-with-metastatic-castration-resistant-prostate-cancer-previously-treated-with-docetaxel-affinity-a-randomised-open-label-international-phase-3-trial
#9
RANDOMIZED CONTROLLED TRIAL
Tomasz M Beer, Sebastien J Hotte, Fred Saad, Boris Alekseev, Vsevolod Matveev, Aude Fléchon, Gwenaelle Gravis, Florence Joly, Kim N Chi, Zafar Malik, Brent Blumenstein, Patricia S Stewart, Cindy A Jacobs, Karim Fizazi
BACKGROUND: Docetaxel and cabazitaxel improve overall survival compared with mitoxantrone in patients with metastatic castration-resistant prostate cancer. Custirsen (OGX011) is a second generation highly specific antisense oligonucleotide that inhibits the production of clusterin, an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance. We aimed to assess whether custirsen in combination with cabazitaxel and prednisone increases overall survival in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel...
November 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28994614/meta-analysis-for-the-efficacy-of-s-1-based-regimens-as-the-first-line-treatment-in-asian-chemotherapy-naive-patients-with-advanced-non-small-cell-lung-cancer
#10
Jianxin Chen, Junhui Wang, Xilin Wu, Xiaoling Che, Yan Zou, Meiling Weng, Qian Miao, Qinhong Zheng
AIM: We performed a meta-analysis to evaluate the efficacy and safety for S-1-based regimens as the first-line treatment in Asian chemotherapy-naive patients with advanced non-small-cell lung cancer. PATIENTS & METHODS: Eligible randomized clinical trials (RCTs) were included, of which data were extracted by inclusion criteria and exclusion one. Odds ratio and hazard ratio (HR) of outcomes including objective response rate (ORR), progression-free survival (PFS), overall survival (OS) and adverse effects (AEs) were explored for the final analysis...
October 10, 2017: Future Oncology
https://www.readbyqxmd.com/read/28835777/current-status-on-the-place-of-folfirinox-in-metastatic-pancreatic-cancer-and-future-directions
#11
REVIEW
Aurélien Lambert, Céline Gavoille, Thierry Conroy
Pancreatic cancer (PC) incidence rates are rapidly increasing in developed countries, with half the patients being metastatic at diagnosis. For decades, fluorouracil, then gemcitabine regimens were the preferred palliative first-line options for fit patients with metastatic PC. FOLFIRINOX (a combination of bolus and infusional fluorouracil, leucovorin, irinotecan and oxaliplatin) was introduced to clinical practice in 2010 due to the results of the phase II/III trial (PRODIGE 4/ACCORD 11) comparing FOLFIRINOX with single-agent gemcitabine as first-line treatment for patients with MPC...
August 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28774769/predictors-for-under-prescribing-antibiotics-in-children-with-respiratory-infections-requiring-antibiotics
#12
Aaron E Kornblith, Jahan Fahimi, Hemal K Kanzaria, Ralph C Wang
BACKGROUND/OBJECTIVE: Previous studies showed variability in the use of diagnostic and therapeutic resources for children with febrile acute respiratory tract infections (ARTI), including antibiotics. Unnecessary antibiotic use has important public and individual health outcomes, but missed antibiotic prescribing also has important consequences. We sought to determine factors associated with antibiotic prescribing in pediatric ARTI, specifically those with pneumonia. METHODS: We assessed national trends in the evaluation and treatment of ARTI for pediatric emergency department (ED) patients by analyzing the National Hospital Ambulatory Medical Care Survey from 2002 to 2013...
February 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28718256/iron-deficiency-anaemia-as-risk-factor-for-simple-febrile-seizures-a-case-control-study
#13
Khawaja Tahir Aziz, Naheem Ahmed, Abdul Ghaffar Nagi
BACKGROUND: Febrile fits is common problem in children. Among other risk factors, iron deficiency anaemia is considered as aggravating factor for febrile fits. Iron deficiency anaemia is preventable and treatable disease. The objective of the study was to find out iron deficiency anaemia as risk factor for febrile fits. METHODS: It was a case control study. Thirty cases of febrile fits were recorded. Control group of 30 cases was taken at the same time with same variables but without febrile fits...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28668694/population-pharmacokinetics-of-cefepime-in-febrile-neutropenia-implications-for-dose-dependent-susceptibility-and-contemporary-dosing-regimens
#14
Nathaniel J Rhodes, Meagan E Grove, Patrick J Kiel, J Nicholas O'Donnell, Laura K Whited, Dusten T Rose, David R Jones, Marc H Scheetz
Alterations in cefepime pharmacokinetic (PK) exposure and decreased bacterial susceptibility increase the risk of treatment failure. The impact of susceptible-dose-dependent (SDD) minimum inhibitory concentrations (MICs), i.e. 4-8 µg/mL, on target attainment rates for cefepime in febrile neutropenia (FN) is unclear. We sought to identify optimal cefepime regimens against SDD cefepime MICs in FN using a modelling and simulation approach. Creatinine clearance (CLCr ) and body surface area (BSA) covariate-adjusted models of clearance were evaluated...
September 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28469332/taxane-combination-chemotherapy-in-breast-cancer-experience-from-a-tertiary-cancer-centre-in-india
#15
Jyoti Bajpai, Deepa Susan, Vijay Patil, Reena Nair, Jaya Ghosh, R A Badwe, Sudeep Gupta
AIMS: Docetaxel, Doxorubicin, Cyclophosphamide (TAC) is an intensive chemotherapy regimen; however, being highly myelosuppressive, its usage is limited in developing countries and hence merits exploration for feasibility and efficacy. MATERIALS AND METHODS: This was a retrospective audit of medical records of breast cancer patients receiving TAC chemotherapy) from 2004 to 2008. Demographic details, toxicity, and outcome analysis were carried out. RESULTS: A total of 133 patients (126 in [neo] adjuvant and 7 in metastatic setting) received TAC chemotherapy...
January 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28448490/the-value-of-daily-platelet-counts-for-predicting-dengue-shock-syndrome-results-from-a-prospective-observational-study-of-2301-vietnamese-children-with-dengue
#16
Phung Khanh Lam, Tran Van Ngoc, Truong Thi Thu Thuy, Nguyen Thi Hong Van, Tran Thi Nhu Thuy, Dong Thi Hoai Tam, Nguyen Minh Dung, Nguyen Thi Hanh Tien, Nguyen Tan Thanh Kieu, Cameron Simmons, Bridget Wills, Marcel Wolbers
BACKGROUND: Dengue is the most important mosquito-borne viral infection to affect humans. Although it usually manifests as a self-limited febrile illness, complications may occur as the fever subsides. A systemic vascular leak syndrome that sometimes progresses to life-threatening hypovolaemic shock is the most serious complication seen in children, typically accompanied by haemoconcentration and thrombocytopenia. Robust evidence on risk factors, especially features present early in the illness course, for progression to dengue shock syndrome (DSS) is lacking...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28298047/development-of-a-prediction-rule-for-diagnosing-postoperative-meningitis-a-cross-sectional-study
#17
Olga Helena Hernández Ortiz, Héctor Iván García García, Fabián Muñoz Ramírez, Juan Sebastián Cardona Flórez, Bladimir Alejandro Gil Valencia, Salvador Ernesto Medina Mantilla, María Juliana Moreno Ochoa, Jorge Eliécer Sará Ochoa, Fabián Jaimes
OBJECTIVE Diagnosing nosocomial meningitis (NM) in neurosurgical patients is difficult. The standard CSF test is not optimal and when it is obtained, CSF cultures are negative in as many as 70% of cases. The goal of this study was to develop a diagnostic prediction rule for postoperative meningitis using a combination of clinical, laboratory, and CSF variables, as well as risk factors (RFs) for CNS infection. METHODS A cross-sectional study was performed in 4 intensive care units in Medellín, Colombia. Patients with a history of neurosurgical procedures were selected at the onset of febrile symptoms and/or after an increase in acute-phase reactants...
January 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28288385/alphaviruses-suppress-host-immunity-by-preventing-myeloid-cell-replication-and-antagonizing-innate-immune-responses
#18
REVIEW
Derek W Trobaugh, William B Klimstra
Alphaviruses are medically important mosquito-borne viruses that cause a range of diseases in humans from febrile illness to arthritis or encephalitis. The innate immune response functions to suppress virus replication through upregulation of antiviral molecules and contributes to development of the adaptive immune response. Myeloid cells act as master regulators of virus infection by initiating both the innate and adaptive immune responses. Alphaviruses are capable of antagonizing individual components of these responses to increase replicative fitness in vivo...
April 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28274962/improving-prescribing-practices-with-rapid-diagnostic-tests-rdts-synthesis-of-10-studies-to-explore-reasons-for-variation-in-malaria-rdt-uptake-and-adherence
#19
COMPARATIVE STUDY
Helen E D Burchett, Baptiste Leurent, Frank Baiden, Kimberly Baltzell, Anders Björkman, Katia Bruxvoort, Siân Clarke, Deborah DiLiberto, Kristina Elfving, Catherine Goodman, Heidi Hopkins, Sham Lal, Marco Liverani, Pascal Magnussen, Andreas Mårtensson, Wilfred Mbacham, Anthony Mbonye, Obinna Onwujekwe, Denise Roth Allen, Delér Shakely, Sarah Staedke, Lasse S Vestergaard, Christopher J M Whitty, Virginia Wiseman, Clare I R Chandler
OBJECTIVES: The overuse of antimalarial drugs is widespread. Effective methods to improve prescribing practice remain unclear. We evaluated the impact of 10 interventions that introduced rapid diagnostic tests for malaria (mRDTs) on the use of tests and adherence to results in different contexts. DESIGN: A comparative case study approach, analysing variation in outcomes across different settings. SETTING: Studies from the ACT Consortium evaluating mRDTs with a range of supporting interventions in 6 malaria endemic countries...
March 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28250620/clinical-score-to-differentiate-scrub-typhus-and-dengue-a-tool-to-differentiate-scrub-typhus-and-dengue
#20
Shubhanker Mitra, Ira Gautam, Mohan Jambugulam, Kundavaram Paul Prabhakar Abhilash, Vishalakshi Jayaseeelan
BACKGROUND: Dengue and scrub typhus share similar clinical and epidemiological features, and are difficult to differentiate at initial presentation. Many places are endemic to both these infections where they comprise the majority of acute undifferentiated febrile illnesses. MATERIALS AND METHODS: We aimed to develop a score that can differentiate scrub typhus from dengue. In this cross-sectional study, 188 cases of scrub typhus and 201 cases of dengue infection who presented to the emergency department or medicine outpatient clinic from September 2012 to April 2013 were included...
January 2017: Journal of Global Infectious Diseases
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