Patrick Lundgren, Prateek V Sharma, Lenka Dohnalová, Kyle Coleman, Giulia T Uhr, Susanna Kircher, Lev Litichevskiy, Klaas Bahnsen, Hélène C Descamps, Christina Demetriadou, Jacqueline Chan, Karthikeyani Chellappa, Timothy O Cox, Yael Heyman, Sarshan R Pather, Clarissa Shoffler, Christopher Petucci, Ophir Shalem, Arjun Raj, Joseph A Baur, Nathaniel W Snyder, Kathryn E Wellen, Maayan Levy, Patrick Seale, Mingyao Li, Christoph A Thaiss
Sustained responses to transient environmental stimuli are important for survival. The mechanisms underlying long-term adaptations to temporary shifts in abiotic factors remain incompletely understood. Here, we find that transient cold exposure leads to sustained transcriptional and metabolic adaptations in brown adipose tissue, which improve thermogenic responses to secondary cold encounter. Primary thermogenic challenge triggers the delayed induction of a lipid biosynthesis programme even after cessation of the original stimulus, which protects from subsequent exposures...
October 2, 2023: Nature metabolism