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https://www.readbyqxmd.com/read/28732421/neuroendoscope-evolving-spectrum-of-utility-in-the-management-of-hydrocephalus-biopsy-and-resection-of-ventricular-tumors-and-cyst-fenestration
#1
Guru Dutta Satyarthee
No abstract text is available yet for this article.
August 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28732417/expanding-spectrum-and-diversifying-role-of-laser-beam-from-intraoperative-cranial-surgery-adjunct-to-magnetic-resonance-guided-minimally-invasive-thermal-laser-ablation-therapy-for-intracranial-tumor
#2
https://www.readbyqxmd.com/read/28732272/screening-of-the-open-scaffolds-collection-from-compounds-australia-identifies-a-new-chemical-entity-with-anthelmintic-activities-against-different-developmental-stages-of-the-barber-s-pole-worm-and-other-parasitic-nematodes
#3
Sarah Preston, Yaqing Jiao, Jonathan B Baell, Jennifer Keiser, Simon Crawford, Anson V Koehler, Tao Wang, Moana M Simpson, Ray M Kaplan, Karla J Cowley, Kaylene J Simpson, Andreas Hofmann, Abdul Jabbar, Robin B Gasser
The discovery and development of novel anthelmintic classes is essential to sustain the control of socioeconomically important parasitic worms of humans and animals. With the aim of offering novel, lead-like scaffolds for drug discovery, Compounds Australia released the 'Open Scaffolds' collection containing 33,999 compounds, with extensive information available on the physicochemical properties of these chemicals. In the present study, we screened 14,464 prioritised compounds from the 'Open Scaffolds' collection against the exsheathed third-stage larvae (xL3s) of Haemonchus contortus using recently developed whole-organism screening assays...
May 28, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28732180/the-role-of-noncoding-genetic-variation-in-isolated-orofacial-clefts
#4
F Thieme, K U Ludwig
In the past decade, medical genetic research has generated multiple discoveries, many of which were obtained via genome-wide association studies (GWASs). A major GWAS finding is that the majority of risk variants for complex traits map to noncoding regions. This has resulted in a paradigm shift in terms of the interpretation of human genomic sequence variation, with more attention now being paid to what was previously termed "junk DNA." Translation of genetic findings into biologically meaningful results requires 1) large-scale and cell-specific efforts to annotate non-protein-coding regions and 2) the integration of comprehensive genomic data sets...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28732111/characterization-of-metabolic-pathways-and-absorption-of-sea-cucumber-saponins-holothurin-a-and-echinoside-a-in-vitro-and-in-vivo
#5
Shanshan Song, Lingyu Zhang, Jian Cao, Gao Xiang, Peixu Cong, Ping Dong, Zhaojie Li, Changhu Xue, Yong Xue, Yuming Wang
Sea cucumber saponins (SCSs) exhibit a wide spectrum of bioactivities, but their metabolic characteristics are not well elucidated. In this study, the metabolism of holothurin A (HA) and echinoside A (EA), 2 major saponins in sea cucumber, by gut microflora were investigated. First, we conducted an in vitro study, where in the SCSs were incubated with intestinal microflora and the metabolites were detected by high pressure liquid chromatography-high resolution mass spectrometry. We also conducted an in vivo study on rats, where in the intestinal contents, serum, urine, and feces were collected and evaluated after oral administration of SCSs...
July 21, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28731944/cancer-immunotherapy-in-older-patients
#6
Kristen A Marrone, Patrick M Forde
Advancing age remains one of the most significant risk factors for cancer development. Changes in the immune system occur with aging, and likely play a role in the increased incidence of malignancy in older patients. With the advent of immune checkpoint inhibitors, and their use in a variety of malignancies, there has been an explosion of clinical trials evaluating their use. Unfortunately, these trials have not shown consistent results in elderly patients, nor have age-specific outcomes been consistently reported...
July 2017: Cancer Journal
https://www.readbyqxmd.com/read/28731865/-joining-the-spots-in-adults-and-young-tots-a-clinicopathological-study-of-henoch-sch%C3%A3-nlein-purpura-iga-vasculitis
#7
Priyanka P Kedia, Rajalakshmi Tirumalae, Divya Puttegowda, Meryl Antony
INTRODUCTION: Henoch-Schönlein Purpura (HSP; IgA vasculitis), the most common vasculitis of childhood, has a wide spectrum of clinical manifestations ranging from palpable purpura with abdominal pain and arthritis to the more morbid renal involvement. AIMS AND OBJECTIVES: To study and correlate the clinical presentation, laboratory values, skin and renal histopathology and immunofluoroscence findings in HSP. MATERIAL AND METHODS: A total of 44 cases of HSP from March 2011 to February 2014 were studied for the above features along with their clinical outcomes...
August 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28731820/uncommon-neoplasms-of-the-biliary-tract-radiological-findings
#8
Vincenza Granata, Roberta Fusco, Orlando Catalano, Salvatore Filice, Antonio Avallone, Mauro Piccirillo, Maddalena Leongito, Raffaele Palaia, Roberto Grassi, Francesco Izzo, Antonella Petrillo
OBJECTIVES: To report our cancer center experience in the biliary tumors incidence other than cholangiocellular-carcinoma (CCC), emphasizing the radiological features. METHODS: 197 patients with biliary disease undergoing Gd-EOB-DTPA-enhanced MRI were reviewed. Four radiologists evaluated retrospectively size, structure, anatomical site, and signal intensity of lesions on MRI. Enhancement-pattern during the arterial-, portal-, and late-phase on US, CT and MR study was assessed as well as the enhancement pattern during the hepatobiliary-phase on MRI...
July 21, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28731773/visualizing-the-efimov-correlation-in-bose-polarons
#9
Mingyuan Sun, Hui Zhai, Xiaoling Cui
The Bose polaron is a quasiparticle of an impurity dressed by surrounding bosons. In few-body physics, it is known that two identical bosons and a third distinguishable particle can form a sequence of Efimov bound states in the vicinity of interspecies scattering resonance. On the other hand, in the Bose polaron system with an impurity atom embedded in many bosons, no signature of Efimov physics has been reported in the existing spectroscopy measurements to date. In this Letter, we propose that a large mass imbalance between a light impurity and heavy bosons can help produce visible signatures of Efimov physics in such a spectroscopy measurement...
July 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28731759/single-molecule-investigation-of-energy-dynamics-in-a-coupled-plasmon-exciton-system
#10
Hiroshi Imada, Kuniyuki Miwa, Miyabi Imai-Imada, Shota Kawahara, Kensuke Kimura, Yousoo Kim
We investigate the near-field interaction between an isolated free-base phthalocyanine molecule and a plasmon localized in the gap between an NaCl-covered Ag(111) surface and the tip apex of a scanning tunneling microscope. When the tip is located in the close proximity of the molecule, asymmetric dips emerge in the broad luminescence spectrum of the plasmon generated by the tunneling current. The origin of the dips is explained by energy transfer between the plasmon and molecular excitons and a quantum mechanical interference effect, where molecular vibrations provide additional degrees of freedom in the dynamic process...
July 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28731594/duplex-doppler-sonographic-assessment-of-the-superior-mesenteric-artery-in-patients-with-mesenteric-panniculitis
#11
Berat Acu, Mehmet Emrah Güven, Mehmet Ali Kaptan, Çiğdem Öztunalı, Erkan Gökçe, Murat Beyhan, Taylan Kara
OBJECTIVES: We aimed to determine how the hemodynamic parameters of the superior mesenteric artery are affected in mesenteric panniculitis. METHODS: Twenty-one patients with a diagnosis of mesenteric panniculitis on computed tomography were evaluated with duplex Doppler sonography. The control group consisted 20 asymptomatic volunteers. The peak systolic velocity, end-diastolic velocity (EDV), resistive index (RI), pulsatility index (PI), blood flow volume, and body mass index were measured in the group of patients with mesenteric panniculitis, and the findings were compared with those of the control group...
July 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28731410/infectious-and-noninfectious-pulmonary-complications-in-patients-with-primary-immunodeficiency-disorders
#12
REVIEW
R Yazdani, H Abolhassani, M Asgardoon, M Shaghaghi, M Modaresi, G Azizi, A Aghamohammadi
Primary immunodeficiency disorders (PIDs) are caused by 1 or more defects of the immune system. Patients are more likely to experience recurrent and/or severe infections and tend to develop a wide range of complications. Respiratory diseases are the main and initial manifestation in most cases and the most common complication. Pulmonary complications cause significant morbidity and mortality in patients with PIDs. Early diagnosis and appropriate treatment can prevent or at least slow the development of respiratory complications...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28731338/tunable-magnetism-and-extraordinary-sunlight-absorbance-in-indium-triphosphide-monolayer
#13
Naihua Miao, Bin Xu, Nicholas C Bristowe, Jian Zhou, Zhimei Sun
Atomically thin two-dimensional (2D) materials have received considerable research interest due to their extraordinary properties and promising applications. Here we predict the mono-layered indium triphosphide (InP3) as a new semiconducting 2D material with a range of favourable functional properties by means of ab initio calculations. The 2D InP3 crystal shows high stability and promise of experimental synthesis. It possesses an indirect band-gap of 1.14 eV and a high electron mobility of 1919 cm(2)V(-1)s(-1), which can be strongly manipulated with applied strain...
July 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28731324/using-infrared-spectroscopy-and-multivariate-analysis-to-detect-antibiotics-resistant-escherichia-coli-bacteria
#14
Uraib Sharaha, Eladio Rodriguez-Diaz, Klaris Riesenberg, Irving J Bigio, Mahmoud Huleihel, Ahmad Salman
Bacterial pathogens are one of the primary causes of human morbidity worldwide. Historically, antibiotics have been highly effective against most bacterial pathogens; however, the increasing resistance of bacteria to a broad spectrum of commonly used antibiotics has become a global health-care problem. Early and rapid determination of bacterial susceptibility to antibiotics has become essential in many clinical settings, and, sometimes, can save lives. Currently classical procedures require at least 48 hours for determining bacterial susceptibility, which can constitute a life-threatening delay for effective treatment...
July 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28731270/polarized-light-emitting-diodes-based-on-patterned-mos2-nanosheet-hole-transport-layer
#15
Gyu Jin Choi, Quyet Van Le, Kyoung Soon Choi, Ki Chang Kwon, Ho Won Jang, Jin Seog Gwag, Soo Young Kim
Here, this study successfully fabricates few-layer MoS2 nanosheets from (NH4 )2 MoS4 and applies them as the hole transport layer as well as the template for highly polarized organic light-emitting diodes (OLEDs). The obtained material consists of polycrystalline MoS2 nanosheets with thicknesses of 2 nm. The MoS2 nanosheets are patterned by rubbing/ion-beam treatment. The Raman spectra shows that {poly(9,9-dioctylfluorene-alt-benzothiadiazole), poly[(9,9-di-n-octylfluorenyl-2,7-diyl)-alt-(benzo[2,1,3]thiadiazol-4,8-diyl)]} (F8BT) on patterned MoS2 exhibits distinctive polarization behavior...
July 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28731230/effects-of-spray-drift-of-glyphosate-on-non-target-terrestrial-plants-a-critical-review
#16
REVIEW
Harald Cederlund
Glyphosate is a widely used broad-spectrum post-emergent herbicide used for weed control in both agricultural and non-agricultural settings. Spray drift of glyphosate can pose a risk to non-target terrestrial plants and plant communities outside the intended area of application, but the lack of a well-established predicted no-effect drift rate makes properly assessing such risk difficult. For this reason, a literature review and meta-analysis was carried out with the aim to determine which level of drift that is likely to cause harm to plants and to explore what spray-reducing targets that would be sufficiently protective...
July 21, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28731162/a-homozygous-myo7a-mutation-associated-to-usher-syndrome-and-unilateral-auditory-neuropathy-spectrum-disorder
#17
Hong Xia, Pengzhi Hu, Lamei Yuan, Wei Xiong, Hongbo Xu, Junhui Yi, Zhijian Yang, Xiong Deng, Yi Guo, Hao Deng
Usher syndrome (USH) is an autosomal recessive disorder characterized by sensorineural hearing loss, progressive visual loss and night blindness due to retinitis pigmentosa (RP), with or without vestibular dysfunction. The purpose of this study was to detect the causative gene in a consanguineous Chinese family with USH. A c.3696_3706del (p.R1232Sfs*72) variant in the myosin VIIa gene (MYO7A) was identified in the homozygous state by exome sequencing. The co‑segregation of the MYO7A c.3696_3706del variant with the phenotype of deafness and progressive visual loss in the USH family was confirmed by Sanger sequencing...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28731081/metal-mediated-reactions-between-dialkylcyanamides-and-acetamidoxime-generate-unusual-nitrosoguanidinate-nickel-ii-complexes
#18
Zarina M Bikbaeva, Alexander S Novikov, Vitalii V Suslonov, Nadezhda A Bokach, Vadim Yu Kukushkin
The nitrosoguanidinate complexes [Ni{NH[double bond, length as m-dash]C(NR2)NN(O)}2] (R2 = Me21, (CH2)4O 2, (CH2)43, (CH2)54, (Me)Ph 5, Ph26, (p-MeC6H4)27) were obtained in low-to-moderate (12-26%) yields but reproducible yields in an unexpected metal-mediated reaction in MeOH between the nickel salt NiCl2·2H2O, N,N-disubstituted cyanamides NCNR2, and the amidoxime MeC([double bond, length as m-dash]NOH)NH2. These complexes were formed along with a spectrum of cyanamide-oxime coupling products. The IR and X-ray data indicate the delocalization within the NNO and NCN systems of the nitrosoguanidinate ligand...
July 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28731071/-potential-impact-of-colors-of-filters-used-in-sunglasses-on-the-melatonin-suppression-process
#19
Grzegorz Owczarek, Grzegorz Gralewicz, Agnieszka Wolska, Natalia Skuza, Piotr Jurowski
BACKGROUND: In this article the methods for determining spectral transmittance of optical radiation in the visible waveband range through selected materials used as optical filters against solar glare were described. MATERIAL AND METHODS: Transmittance coefficients specified for the fraction of light passing through tested filters, taking into account the mechanism of eye adaptation to daylight and night vision and the melatonin suppression process were compared for 4 dyed sunglass filters...
July 10, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28730918/clinical-and-economic-implications-of-urinary-tract-infections
#20
Samantha N Steiger, Rachel R Comito, David P Nicolau
Urinary tract infections represent one of the most frequent reasons for hospitalization. As a result of their prevalence from community-based origins as well as those which develop in hospital setting, this constellation of infections represents a tremendous burden to the global healthcare system. Areas Covered: Over the last several decades the management of these infections has become more complicated due to the underlying comorbid conditions of the patients as well as escalating antimicrobial resistance to many of the most frequently used oral and parenteral agents...
July 21, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
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