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https://www.readbyqxmd.com/read/29141393/-the-role-of-myelin-oligodendrocyte-glycoprotein-antibodies-for-detection-of-demyelinating-optic-neuritis
#1
S H Wei, Y Zhao
The incidence of neuromyelitis optica spectrum disorders (NMOSD) in the Asian population is much higher than in Europe and North America. Optic neuritis is the first sign of NMOSD for some people. Identification of aquaporin 4 antibody is a milestone in the research of NMOSD and has been included in the diagnosis standard of NMOSD, but about 20% to 30% of NMOSD patients is aquaporin 4 antibody-negative. With the cell-based assays, oligodendrocyte glycoprotein antibodies in demyelinating diseases of the central nervous system have aroused the attention of researchers...
November 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29141317/-study-of-gene-mutation-in-62-hemophilia-a-children
#2
Q Hu, A G Liu, L Q Zhang, A Zhang, Y Q Wang, S M Wang, Y J Lu, X Wang
Objective: To analyze the mutation type of FⅧ gene in children with hemophilia A and to explore the relationship among hemophilia gene mutation spectrum, gene mutation and clinical phenotype. Method: Sixty-two children with hemophilia A from Department of Pediatric Hematology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology between January 2015 and March 2017 were enrolled. All patients were male, aged from 4 months to 7 years and F Ⅷ activity ranged 0.2%-11.0%. Fifty cases had severe, 10 cases had moderate and 2 cases had mild hemophilia A...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29141250/a-small-supernumerary-marker-derived-from-the-pericentromeric-region-of-chromosome-5-case-report-and-delineation-of-partial-trisomy-5p-phenotype
#3
Letizia Camerota, Mariabernarda Pitzianti, Diana Postorivo, Anna M Nardone, Claudio Ligas, Costanzo Moretti, Augusto Pasini, Francesco Brancati
A 17-year-old girl presented with a distinct phenotype mainly featuring craniofacial dysmorphism, including a disproportioned large, round, elongated face; hypertelorism; deep-set eyes with short palpebral fissures; obesity (BMI 37), and a neuropsychiatric disorder with high-functioning autism. Postnatal conventional cytogenetic analyses from peripheral blood revealed a mosaic small supernumerary marker chromosome (sSMC) with a mos 47,XX,+mar[7]/46,XX[43] karyotype. By cenM-FISH technique, the sSMC was identified as a ring derivative of chromosome 5...
November 16, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/29141225/a-comprehensive-patient-derived-xenograft-collection-representing-the-heterogeneity-of-melanoma
#4
Clemens Krepler, Katrin Sproesser, Patricia Brafford, Marilda Beqiri, Bradley Garman, Min Xiao, Batool Shannan, Andrea Watters, Michela Perego, Gao Zhang, Adina Vultur, Xiangfan Yin, Qin Liu, Ioannis N Anastopoulos, Bradley Wubbenhorst, Melissa A Wilson, Wei Xu, Giorgos Karakousis, Michael Feldman, Xiaowei Xu, Ravi Amaravadi, Tara C Gangadhar, David E Elder, Lauren E Haydu, Jennifer A Wargo, Michael A Davies, Yiling Lu, Gordon B Mills, Dennie T Frederick, Michal Barzily-Rokni, Keith T Flaherty, Dave S Hoon, Michael Guarino, Joseph J Bennett, Randall W Ryan, Nicholas J Petrelli, Carol L Shields, Mizue Terai, Takami Sato, Andrew E Aplin, Alexander Roesch, David Darr, Steve Angus, Rakesh Kumar, Ensar Halilovic, Giordano Caponigro, Sebastien Jeay, Jens Wuerthner, Annette Walter, Matthias Ocker, Matthew B Boxer, Lynn Schuchter, Katherine L Nathanson, Meenhard Herlyn
Therapy of advanced melanoma is changing dramatically. Following mutational and biological subclassification of this heterogeneous cancer, several targeted and immune therapies were approved and increased survival significantly. To facilitate further advancements through pre-clinical in vivo modeling, we have established 459 patient-derived xenografts (PDX) and live tissue samples from 384 patients representing the full spectrum of clinical, therapeutic, mutational, and biological heterogeneity of melanoma...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29141188/autistic-traits-modulate-the-activity-of-the-ventromedial-prefrontal-cortex-in-response-to-female-faces
#5
Yui Murakami, Shinya Sakai, Kenta Takeda, Daisuke Sawamura, Kazuki Yoshida, Takamichi Hirose, Chisa Ikeda, Hiroki Mani, Toru Yamamoto, Ayahito Ito
Previous findings have revealed abnormal visual attention or processing of faces among individuals with autism spectrum condition (ASC). However, little attention has been paid to the relationship between autistic traits and neural mechanisms associated with representing facial values. Using fMRI, we investigated the patterns of brain activity in the vmPFC and VS in response to faces of elderly males, elderly females, young males, and young females. During fMRI, subjects with a relatively high autism quotient (high group) and those with a relatively low autism quotient (low group) were presented with a face and asked to rate its pleasantness...
November 12, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29141068/new-insight-into-the-pathophysiology-of-hair-loss-trigger-a-paradigm-shift-in-the-treatment-approach
#6
Neil S Sadick, Valerie D Callender, Leon H Kircik, Sophia Kogan
<p>Hair loss affects millions of men and women of all ages and ethnicities, impacting appearance, social interactions, and psycho-emotional well-being. Although a number of options are available, they are limited, carry a potential risk of side effects, and none have proven to be comprehensive for treatment of hair loss. Across the spectrum of hair loss disorders, there has long been a segmentation into distinct mechanisms, driving the main trend in current therapeutics to focus on targeting single molecules or pathways...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29140806/florid-granuloma-annulare-like-reaction-in-regional-lymph-nodes-after-regression-of-red-pigment-in-tattoos
#7
Michael D Carter, Jonathan Trites, Shelly A McNeil, Noreen N M Walsh, Martin J Bullock
A healthy 50-year-old woman had a tattoo performed on the posterior aspect of her neck and another on the dorsum of her left foot. Several weeks later, she noted redness, tenderness, and intense pruritis at both tattoo sites. Treatment with cephalexin and hydrocortisone cream was instituted, without success. Within a few months, the red, but not black, pigment had disappeared from both tattoos and was replaced by pale areas of scarring. Persistently enlarged left supraclavicular and suboccipital lymph nodes were excised 7 and 10 months after receipt of the tattoos, respectively...
October 30, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29140700/high-pressure-behavior-of-silver-fluorides-up-to-40-gpa
#8
Adam Grzelak, Jakub Gawraczyński, Tomasz Jaroń, Dominik Kurzydłowski, Armand Budzianowski, Zoran Mazej, Piotr J Leszczyński, Vitali B Prakapenka, Mariana Derzsi, Viktor V Struzhkin, Wojciech Grochala
A combined experimental-theoretical study of silver(I) and silver(II) fluorides under high pressure is reported. For Ag(I), the CsCl-type structure is stable to at least 39 GPa; the overtone of the IR-active mode is seen in the Raman spectrum. Its Ag(II)F2 sibling is a unique compound in many ways: it is more covalent than other known difluorides, crystallizes in a layered structure, and is enormously reactive. Using X-ray diffraction and guided by theoretical calculations (density functional theory), we have been able to elucidate crystal structures of high-pressure polymorphs of AgF2...
November 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29140559/comparative-efficacy-and-tolerability-of-solifenacin-5%C3%A2-mg-day-versus-other-oral-antimuscarinic-agents-in-overactive-bladder-a-systematic-literature-review-and-network-meta-analysis
#9
Jameel Nazir, Con Kelleher, Samuel Aballéa, Khaled Maman, Zalmai Hakimi, Colette Mankowski, Isaac Odeyemi
AIMS: To compare efficacy and tolerability of solifenacin 5 mg/day versus other oral antimuscarinic agents for the treatment of overactive bladder (OAB). METHODS: Literature searches of MEDLINE, Embase, and the Cochrane Library were undertaken to identify randomized controlled trials in OAB (2000-2015) for antimuscarinic agents. A network meta-analysis (NMA) was performed to estimate efficacy and tolerability outcomes for solifenacin 5 mg/day relative to other antimuscarinics...
November 15, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29140515/surveillance-for-q-fever-endocarditis-in-the-united-states-1999-2015
#10
Anne Straily, F Scott Dahlgren, Amy Peterson, Christopher D Paddock
Background: Q fever is a worldwide zoonosis caused by Coxiella burnetii. In some persons, particularly those with cardiac valve disease, infection with C. burnetii can cause a life-threatening infective endocarditis. There are few descriptive analyses of Q fever endocarditis in the United States. Methods: Q fever case report forms submitted during 1999-2015 were reviewed to identify reports describing endocarditis. Cases were categorized as confirmed or probable using criteria defined by the Council for State and Territorial Epidemiologists (CSTE)...
November 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29140418/perioperative-management-of-the-obese-surgical-patient
#11
L H Lang, K Parekh, B Y K Tsui, M Maze
Introduction: The escalation in the prevalence of obesity throughout the world has led to an upsurge in the number of obese surgical patients to whom perioperative care needs to be delivered. Sources of data: After determining the scope of the review, the authors used PubMed with select phrases encompassing the words in the scope. Both preclinical and clinical reports were considered. Areas of agreement: There were no controversies regarding preoperative management and the intraoperative care of the obese surgical patient...
November 13, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/29140361/self-referenced-octave-wide-subharmonic-gap-optical-parametric-oscillator-centered-at-3%C3%A2-%C3%A2-%C3%AE-m-and-pumped-by-an-er-fiber-laser
#12
Qitian Ru, Zachary E Loparo, XiaoSheng Zhang, Sean Crystal, Subith Vasu, Peter G Schunemann, Konstantin L Vodopyanov
We report an octave-wide mid-IR spectrum (2.3-4.8 μm) obtained from a subharmonic optical parametric oscillator (OPO) based on a newly developed nonlinear crystal, orientation-patterned gallium phosphide (OP-GaP), which was synchronously pumped by a femtosecond 1560 nm fiber laser. We proved that the octave-wide output is in the form of a single frequency comb. The observed f-to-2f frequency beats, originating directly from the OPO, can be used for self-referencing and phase locking of the pump laser comb with no need for supercontinuum generation...
November 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29140322/fourier-processing-with-partially-coherent-fields
#13
Taco D Visser, Govind P Agrawal, Peter W Milonni
We describe how Fourier signal processing techniques can be generalized to partially coherent fields. Using standard coherence theory, we first show that focusing of a partially coherent beam by a lens modifies its coherence properties. We then consider a 4f imaging system composed of two lenses and discuss how spatial filtering in the Fourier plane allows one to tune the coherence properties of the beam. This, in turn, provides control over the beam's directionality, spectrum, and degree of polarization.
November 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29140302/danger-high-voltage-the-role-of-voltage-gated-calcium-channels-in-central-nervous-system-pathology
#14
REVIEW
Andrea Schampel, Stefanie Kuerten
Voltage-gated calcium channels (VGCCs) are widely distributed within the central nervous system (CNS) and presumed to play an important role in the pathophysiology of a broad spectrum of CNS disorders including Alzheimer's and Parkinson's disease as well as multiple sclerosis. Several calcium channel blockers have been in clinical practice for many years so that their toxicity and side effects are well studied. However, these drugs are primarily used for the treatment of cardiovascular diseases and most if not all effects on brain functions are secondary to peripheral effects on blood pressure and circulation...
November 15, 2017: Cells
https://www.readbyqxmd.com/read/29140267/detection-of-partial-discharge-sources-using-uhf-sensors-and-blind-signal-separation
#15
Carlos Boya, Guillermo Robles, Emilio Parrado-Hernández, Marta Ruiz-Llata
The measurement of the emitted electromagnetic energy in the UHF region of the spectrum allows the detection of partial discharges and, thus, the on-line monitoring of the condition of the insulation of electrical equipment. Unfortunately, determining the affected asset is difficult when there are several simultaneous insulation defects. This paper proposes the use of an independent component analysis (ICA) algorithm to separate the signals coming from different partial discharge (PD) sources. The performance of the algorithm has been tested using UHF signals generated by test objects...
November 15, 2017: Sensors
https://www.readbyqxmd.com/read/29140240/case-report-strongyloides-stercoralis-hyperinfection-in-a-patient-with-chronic-lymphocytic-leukemia
#16
Richelle Guerrero-Wooley, Ernesto Aranda-Aguirre, Wencheng Li, Aimee Wilkin, Elizabeth Palavecino
Strongyloides stercoralis is an intestinal nematode that can cause disseminated infection in an immunocompromised host. It is most commonly acquired in developing countries. It was previously a common infection in many parts of the United States, particularly in the Appalachian region, but is rarely identified currently. Here, we describe a patient born and raised in Appalachia, with no history of travel outside the United States, who presented with chronic lymphocytic leukemia and S. stercoralis hyperinfection characterized by acute respiratory failure, altered mental status, and extended-spectrum-beta-lactamase Klebsiella pneumoniae bacteremia...
November 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29139642/matrilineal-heritage-in-southern-iberia-reveals-deep-genetic-links-between-continents
#17
Candela L Hernández, Rosario Calderón
Within the Mediterranean Basin, the Iberian Peninsula has been a focus of attraction for several cultures and civilizations from its prehistory and history, making it a target territory for studying human migration patterns and peopling processes using a wide and heterogeneous spectrum of genomic markers. While its Cantabrian fringe represents the most regularly analysed area in terms of its mitochondrial diversity, the absence of monographic surveys on the maternal genetic composition of southern Iberians (i...
March 2017: Collegium Antropologicum
https://www.readbyqxmd.com/read/29139490/synthesis-and-shift-reagent-assisted-full-nmr-assignment-of-bacterial-z8-e2-%C3%AF-undecaprenol
#18
Mijoon Lee, Dusan Hesek, Jaroslav Zajíček, Jed F Fisher, Shahriar Mobashery
The repeating isoprene unit is a fundamental biosynthetic motif. The repetitive structure presents challenges both for synthesis and for structural characterization. In this synthesis of the (Z8,E2,ω)-undecaprenol of prokaryotic glycobiology, we exemplify solutions to these challenges. Allylation of sulfone-derived carbanions controlled the stereochemistry, and its proof-of-structure was secured by Eu(hfc)3 complexation to disperse the overlaid resonances of its (1)H NMR spectrum.
November 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29139381/-titin-related-muscle-disorders-an-expanding-spectrum
#19
Ana Ferreiro, J Andoni Urtizberea
Titin-related diseases of the skeletal and cardiac muscles open a new, fruitful chapter of myology. Confined for a long time to a limited number of clinical entities, the phenotypic spectrum of titinopthies is nowadays expanding rapidly together with the discovery of many pathogenic mutations of the TTN gene. Like for many genes of large size, the fine tuning and use of high-throughput sequencing (NGS) constitutes a little revolution in the field. This powerful tool allows, although with real technical hurdles, the establishment of the definite diagnosis of titinopathy...
November 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29139322/how-pupils-on-the-autism-spectrum-make-sense-of-themselves-in-the-context-of-their-experiences-in-a-mainstream-school-setting-a-qualitative-metasynthesis
#20
Emma I Williams, Kate Gleeson, Bridget E Jones
Evidence that interpersonal interactions and self-appraisal in social context are crucial in developing self-understanding raises concerns about how pupils with autism spectrum disorder make sense of themselves in school settings where many experience social marginalisation. Metasynthesis was used to systematically extract and integrate findings from qualitative studies examining the mainstream school experiences of these students. Synthesised findings identified three, intermeshing, aspects of experience which contribute to many pupils with autism spectrum disorder making sense of themselves as 'different' to typical peers in a negative way: difficulties linked to autism spectrum disorder; interpersonal relationships, particularly with peers; and accessibility of the school environment...
November 1, 2017: Autism: the International Journal of Research and Practice
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