Yong Zhu, Xiaoxiao Meng, Xian Zhu, Jiaxiang Zhang, Hui Lv, Feiyao Wang, Jinfeng Wang, Cheng Chen, Mengting Chen, Dapeng Wang, Wei Jin, Rui Tian, Ruilan Wang
Pulmonary fibrosis involves destruction of the lung parenchyma and extracellular matrix deposition. Effective treatments for pulmonary fibrosis are lacking and its pathogenesis is still unclear. Studies have found that epithelial-mesenchymal transition (EMT) of alveolar epithelial cells (AECs) plays an important role in progression of pulmonary fibrosis. Thus, an in-depth exploration of its mechanism might identify new therapeutic targets. In this study, we revealed that a novel circular RNA, MKLN1 (circMKLN1), was significantly elevated in two pulmonary fibrosis models (intraperitoneally with PQ, 50 mg/kg for 7 days, and intratracheally with BLM, 5 mg/kg for 28 days)...
March 9, 2024: Archives of Toxicology