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https://www.readbyqxmd.com/read/29161469/validation-of-a-definition-for-flare-in-patients-with-established-gout
#1
Angelo L Gaffo, Nicola Dalbeth, Kenneth G Saag, Jasvinder A Singh, Elizabeth J Rahn, Amy S Mudano, Yi-Hsing Chen, Ching-Tsai Lin, Sandra Bourke, Worawit Louthrenoo, Janitzia Vazquez-Mellado, Hansel Hernández-Llinas, Tuhina Neogi, Ana Beatriz Vargas-Santos, Geraldo da Rocha Castelar-Pinheiro, Rodrigo B C Amorim, Till Uhlig, Hilde B Hammer, Maxim Eliseev, Fernando Perez-Ruiz, Lorenzo Cavagna, Geraldine M McCarthy, Lisa K Stamp, Martijn Gerritsen, Viktoria Fana, Francisca Sivera, William Taylor
OBJECTIVE: To perform external validation of provisional gout flare (attack) definitions in patients with gout. METHODS: We enrolled 509 participants with gout from 17 international sites in a cross-sectional study performed during routine clinical care and collected data to classify participants as experiencing a gout flare or not according to a provisional definition. A local expert rheumatologist performed the final independent adjudication of the gout flare status...
November 21, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29161393/quality-safety-and-outcomes-in-anaesthesia-what-s-to-be-done-an-international-perspective
#2
C J Peden, M Campbell, G Aggarwal
This article reviews of some of the key topics and challenges in quality, safety, and the measurement and improvement of outcomes in anaesthesia. The topics were selected based on the perspective of an individual with quality and safety expertise and recent experience of the specialty in both the UK and USA. The review does not seek to be exhaustive or systematic, but to highlight current areas of concern and potential solutions. The topic is subdivided into sections where the system of health care is viewed from different levels...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29161062/exposure-to-marijuana-marketing-after-legalization-of-retail-sales-oregonians-experiences-2015-2016
#3
Steven C Fiala, Julia A Dilley, Caislin L Firth, Julie E Maher
OBJECTIVES: To assess exposure to marijuana advertising in Oregon after the start of retail marijuana sales in October 2015. METHODS: We conducted a repeated cross-sectional online survey of 4001 Oregon adults aged 18 years and older in November 2015 and April-May 2016. We assessed subgroup differences by using the Pearson χ(2) test. RESULTS: More than half of adults (54.8%) statewide reported seeing marijuana advertising in the past month...
November 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29161040/does-the-cl-ch4-%C3%A2-h-ch3cl-reaction-proceed-via-walden-inversion
#4
Laszlo Krotos, Gabor Czako
We report a chemically accurate global ab initio full-dimensional potential energy surface (PES) for the Cl(2P3/2) + CH4 reaction improving the high-energy region of our previous PES [Czakó, G.; Bowman, J. M. Science 2011, 334, 343-346]. Besides the abstraction (HCl + CH3) and the Walden-inversion substitution (H + CH3Cl) channels, the new PES accurately describes novel substitution pathways via retention of configuration. Quasiclassical trajectory simulation on this PES reveals that the substitution channel opens around 40 kcal/mol collision energy via Walden inversion and the retention cross sections raise from ∼50 kcal/mol...
November 21, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29160785/scleral-pits-in-choroideremia-implications-for-retinal-gene-therapy
#5
Abdullah A Al-Qahtani, Shakoor Ba-Ali, Talal Alabduljalil, Aaron S Coyner, Rachel C Patel, Richard G Weleber, Aniz Girach, Søren K Christensen, Michael Larsen, Mark E Pennesi, Paul Yang
PURPOSE: We report a novel finding on spectral domain optical coherence tomography in patients with choroideremia, which we describe as scleral pits (SCPs). METHODS: Cross-sectional observational case series of 36 patients with choroideremia, who underwent ophthalmic examination and multimodal imaging, including optical coherence tomography of the macula. Optical coherence tomography images were reviewed for SCP, which were defined as discrete tracts of hyporeflectivity that traverse the sclera with or without the involvement of Bruch membrane, retinal pigment epithelium, and retina...
November 16, 2017: Retina
https://www.readbyqxmd.com/read/29160619/tendinopathy-diagnosis-and-treatment-monitoring-using-attenuated-total-reflectance-fourier-transform-infrared-spectroscopy
#6
Tanmoy T Bhattacharjee, Mariana C Nicodemo, Luciana B Sant'Anna, Emilia A Lo Schiavo Arisawa, Leandro Raniero
Tendinopathy, an important sports injury afflicting athletes and general public, is associated with huge economic losses. The currently used diagnostic tests are subjective, show moderate sensitivity and specificity; while treatment failures persist despite advances in therapy. This highlights the need for tendinopathy diagnostic and treatment monitoring tools. The current study investigates tendon injury, natural healing and effect of treatment using ATR-FTIR complemented with histopathology. Control (C), injured (I) and treated (T) rat tendons were extracted 3, 7, 14 and 28 days post injury/treatment, representing phases of healing; and subjected to H&E staining as well as spectroscopy...
November 21, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29160571/sacral-neuromodulation-and-pregnancy-results-of-a-national-survey-carried-out-for-the-neuro-urology-committee-of-the-french-association-of-urology-afu
#7
Pauline Roulette, Evelyne Castel-Lacanal, Sylvain Sanson, Romain Caremel, Véronique Phé, Stéphane Bart, Franck Duchêne, Marianne De Sèze, Alexia Even, Andréa Manunta, Maria C Scheiber-Nogueira, Pascal Mouracade, Catherine-Marie Loche, Emmanuel Chartier-Kastler, Alain Ruffion, Gilles Karsenty, Xavier Gamé
AIMS: To assess the impact of sacral neuromodulation (SNM) on pregnancy and vice-versa, by identifying women who had received SNM for lower-urinary tract symptoms (LUTS) and had become pregnant. METHODS: A cross-sectional descriptive study was carried out based on responses to an on-line questionnaire sent to practitioners listed on the InterStim enCaptureTM National Registry. Questions were related to pre-pregnancy health and SNM efficacy, deactivation of the device, its impact on LUTS, childbirth, the infant, its reactivation and postpartum effectiveness...
November 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29160451/main-characteristics-of-patients-of-primary-health-care-services-in-brazil
#8
Ione Aquemi Guibu, José Cássio de Moraes, Augusto Afonso Guerra, Ediná Alves Costa, Francisco de Assis Acurcio, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mario Soeiro, Silvana Nair Leite, Juliana Álvares
OBJECTIVE: To characterize patients of primary health care services according to demographic and socioeconomic aspects, habits and lifestyle, health condition, and demand for health services and medicines. METHODS: This study is part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services), a cross-sectional study carried out between 2014 and 2015...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29160436/use-of-injected-heroin-and-risk-of-hepatitis-c-in-three-cities-in-colombia
#9
Dedsy Yajaira Berbesi-Fernández, Angela Maria Segura-Cardona, Liliana Patricia Montoya-Velez, Alexandra Ángel Santamaría
INTRODUCTION: Hepatitis C is one of the most neglected diseases by governments internationally. OBJECTIVE: Identify the prevalence of hepatitis C and associated injection drug users in three cities of factors Colombia. METHODS: Cross-sectional study of 668 injecting drug users recruited through respondent-driven sampling, inquired about demographic characteristics and risk behaviors. Laboratory testing was used on filter paper and cases of hepatitis C viral load tests with RNA were confirmed...
July 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/29160380/frequency-of-copd-in-health-care-workers-who-smoke
#10
Ivan Kopitovic, Aleksandar Bokan, Ilija Andrijevic, Miroslav Ilic, Sanja Marinkovic, Dragana Milicic, Marija Vukoja
OBJECTIVE: COPD is one of the major causes of morbidity and mortality worldwide. Health care providers should counsel their smoking patients with COPD to quit smoking as the first treatment step. However, in countries with high prevalences of smoking, health care workers may also be smokers. The aim of this study was to determine the frequency and severity of COPD in health care workers who smoke. METHODS: This was a cross-sectional study. All health care workers who smoke, from nine health care centers in Serbia, were invited to participate in the study and perform spirometry...
September 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29160238/thermal-transport-in-epitaxial-si1-x-ge-x-alloy-nanowires-with-varying-composition-and-morphology
#11
A El Sachat, J S Reparaz, J Spiece, M I Alonso, A R Goñi, M Garriga, P O Vaccaro, M R Wagner, O V Kolosov, C M Sotomayor Torres, F Alzina
We report on structural, compositional, and thermal characterization of self-assembled in-plane epitaxial Si1-x Ge x alloy nanowires grown by molecular beam epitaxy on Si (001) substrates. The thermal properties were studied by means of scanning thermal microscopy (SThM), while the microstructural characteristics, the spatial distribution of the elemental composition of the alloy nanowires and the sample surface were investigated by transmission electron microscopy and energy dispersive x-ray microanalysis...
November 21, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29159929/s100%C3%AE-in-newborns-after-c-section-with-general-vs-epidural-anesthesia-a-prospective-observational-study
#12
Z Xu, Z Liu, Y Zhang, C Jin, F Shen, Y Yu, T Cheek, O Onuoha, G Liang, R Month, J Atkins, K M Tran, H Wei
BACKGROUND: Preclinical evidence suggests that general anesthetics can dose dependently induce neurodegeneration in the developing brains of animals which can be reliably determined by measurement of blood S100β, but this correlation remains unclear in humans. We hypothesized that S100β would not be increased in cord arterial blood of fetuses exposed briefly to general anesthetics during a C-section, compared with epidural anesthesia. METHODS: A prospective observational clinical study comparatively measured changes of brain damage biomarker S100β ratio of umbilical artery over vein (changes after fetus circulation) immediately after delivery under C-section with either epidural or general anesthesia...
November 20, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29159892/reliability-of-body-weight-scalars-on-the-assessment-of-propofol-induction-dose-in-obese-patients
#13
A M Araújo, H S Machado, A C Falcão, P Soares-da-Silva
BACKGROUND: Obese patients require specific perioperative care when compared with non-obese patients. The present study aimed to analyse the ability of size descriptors to estimate propofol induction dose in class II and III obese patients. METHODS: A cross-sectional study on adult patients with body mass index (BMI) equal to or greater than 35 kg/m(2) and on adult patients with BMI lower than 35 kg/m(2) was carried out. General anaesthesia was induced with remifentanil, propofol and rocuronium...
November 21, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29159835/precarious-schedules-linked-with-workplace-aggression-in-a-high-risk-occupation
#14
David A Hurtado, Lisset M Dumet, Samuel A Greenspan, Miguel Marino, Kimberly Bernard
INTRODUCTION: Night work and prolonged work hours increase the risk for workplace aggression, however, the risk related to precarious schedules remains unknown. METHODS: Cross-sectional study among Parole Probation Officers (PPOs) (n = 35). A precarious schedules index was created including the following indicators (a) experiencing one or more unexpected shifts during the last 4 weeks; (b) having minimal control over work hours; and (c) shifts notifications of less than a week...
November 21, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/29159760/body-mass-index-age-at-breast-cancer-diagnosis-and-breast-cancer-subtype-a-cross-sectional-study
#15
O Brouckaert, K Van Asten, A Laenen, A Soubry, A Smeets, I Nevelstreen, I Vergote, H Wildiers, R Paridaens, E Van Limbergen, C Weltens, P Moerman, G Floris, P Neven
PURPOSE: Evidence suggests that premenopausal obesity decreases and postmenopausal obesity increases breast cancer risk. Because it is not well known whether this is subtype dependent, we studied the association between body mass index (BMI) and age at breast cancer diagnosis, or the probability of being diagnosed with a specific breast cancer phenotype, by menopausal status. METHODS: All patients with non-metastatic operable breast cancer from the University Hospital Leuven diagnosed between January 1, 2000 and December 31, 2013 were included (n = 7020) in this cross-sectional study...
November 20, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29159595/resilience-and-physical-and-mental-well-being-in-adults-with-and-without-hiv
#16
Jennifer A McGowan, James Brown, Fiona C Lampe, Marc Lipman, Colette Smith, Alison Rodger
Resilience has been related to improved physical and mental health, and is thought to improve with age. No studies have explored the relationship between resilience, ageing with HIV, and well-being. A cross sectional observational study performed on UK HIV positive (N = 195) and HIV negative adults (N = 130). Associations of both age and 'time diagnosed with HIV' with resilience (RS-14) were assessed, and the association of resilience with depression, anxiety symptoms (PHQ-9 and GAD-7), and problems with activities of daily living (ADLs) (Euroqol 5D-3L)...
November 20, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29159418/reliability-and-convergent-validity-of-the-five-step-test-in-people-with-chronic-stroke
#17
Shamay S M Ng, Mimi M Y Tse, Eric W C Tam, Cynthia Y Y Lai
OBJECTIVES: (i) To estimate the intra-rater, inter-rater and test-retest reliabilities of the Five-Step Test (FST), as well as the minimum detectable change in FST completion times in people with stroke. (ii) To estimate the convergent validity of the FST with other measures of stroke-specific impairments. (iii) To identify the best cut-off times for distinguishing FST performance in people with stroke from that of healthy older adults. DESIGN: A cross-sectional study...
November 17, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29159396/association-of-nonalcoholic-fatty-liver-disease-with-lower-brain-volume-in-healthy-middle-aged-adults-in-the-framingham-study
#18
Galit Weinstein, Shira Zelber-Sagi, Sarah R Preis, Alexa S Beiser, Charles DeCarli, Elizabeth K Speliotes, Claudia L Satizabal, Ramachandran S Vasan, Sudha Seshadri
Importance: Nonalcoholic fatty liver disease (NAFLD) is a common condition that is most often asymptomatic. It is associated with metabolic syndrome, incident diabetes, carotid atherosclerosis, and endothelial dysfunction, conditions that in turn are strongly linked with brain damage and cognitive impairment. However, it is not known whether NAFLD is associated with structural brain measures in humans. Objective: To assess the association between prevalent NAFLD and brain magnetic resonance imaging (MRI) measures...
November 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29159190/divergent-neural-responses-to-narrative-speech-in-disorders-of-consciousness
#19
Ivan Iotzov, Brian C Fidali, Agustin Petroni, Mary M Conte, Nicholas D Schiff, Lucas C Parra
Objective: Clinical assessment of auditory attention in patients with disorders of consciousness is often limited by motor impairment. Here, we employ intersubject correlations among electroencephalography responses to naturalistic speech in order to assay auditory attention among patients and healthy controls. Methods: Electroencephalographic data were recorded from 20 subjects with disorders of consciousness and 14 healthy controls during of two narrative audio stimuli, presented both forwards and time-reversed...
November 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29158908/dairy-production-practices-and-associated-risks-for-bovine-vaccinia-exposure-in-cattle-brazil
#20
I A Borges, A M McCollum, J M Mehal, D Haberling, L A L Dutra, F N Vieira, L A O Andrade, E G Kroon, R C Holman, M G Reynolds, G S Trindade
A cross-sectional serosurvey was performed to identify environmental features or practices of dairy farms associated with risk for exposure to vaccinia-like viruses in dairy cattle in Brazil. Sera from 103 cows from 18 farms in Minas Gerais state were examined for Orthopoxvirus-neutralizing antibodies. A database of 243 binary or multiple-selection categorical variables regarding the physical features and surrounding ecology of each property was obtained. Thirteen of 46 presumptive predictor variables were found to be significantly associated with Orthopoxvirus serostatus by univariate logistic regression methods...
November 2017: New Microbes and New Infections
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