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https://www.readbyqxmd.com/read/28098923/-ssris-and-depressive-symptoms-in-schizophrenia-a-systematic-review
#1
H G van Dijk, E A Dapper, C H Vinkers
Patients with schizophrenia frequently have depressive symptoms. Current guidelines do not provide specific recommendations regarding the treatment of these symptoms, nor do they mention the role that selective serotonin reuptake inhibitors (ssris) can play in the treatment.<br/> AIM: To investigate whether ssris are more effective than placebo in treating depressive symptoms in patients with schizophrenia.<br/> METHOD: We searched the literature systematically using PubMed, embase, Cochrane Library and Psycinfo...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28098052/effect-of-maternal-dietary-counselling-during-the-1st-year-of-life-on-glucose-profile-and-insulin-resistance-at-the-age-of-8-years-a-randomised-field-trial
#2
Cintia S Costa, Paula D B Campagnolo, L H Lumey, Marcia R Vitolo
Education interventions that stimulate complementary feeding practices can improve the nutritional status of children and may protect against future chronic diseases. We assessed the long-term effectiveness of dietary intervention during the 1st year of life on insulin resistance levels, and investigated the relationship between insulin resistance and weight changes over time. A randomised field trial was conducted among 500 mothers who gave birth to full-term infants between October 2001 and June 2002 in a low-income area in São Leopoldo, Brazil...
January 18, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28097758/alpha-blockers-in-the-management-of-ureteric-lithiasis-a-meta-analysis
#3
Nicholas Raison, Kamran Ahmed, Oliver Brunckhorst, Prokar Dasgupta
INTRODUCTION: Effective medical expulsion for ureteric stones with α-blockers offers numerous advantages over surgical alternatives. However, its effectiveness remains uncertain and with the publication of new trial data, the available evidence requires reappraisal. OBJECTIVE: The aim of this study was to assess the efficacy of α-blockers the management of ureteric lithiasis. METHODS: A systematic review of the literature, with predefined search criteria, was conducted using PubMed and Embase...
January 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28097487/inter-individual-responses-of-maximal-oxygen-uptake-to-exercise-training-a-critical-review
#4
Philip J Williamson, Greg Atkinson, Alan M Batterham
It has recently been reported how to quantify inter-individual differences in the response to an exercise intervention using the standard deviation of the change scores, as well as how to appraise these differences for clinical relevance. In a parallel-group randomised controlled trial, the key trigger for further investigation into inter-individual responses is when the standard deviation of change in the intervention sample is substantially larger than the same standard deviation derived from a suitable comparator sample...
January 17, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28096254/factors-predicting-antibiotic-prescription-and-referral-to-hospital-for-children-with-respiratory-symptoms-secondary-analysis-of-a-randomised-controlled-study-at-out-of-hours-services-in-primary-care
#5
Ingrid Keilegavlen Rebnord, Hogne Sandvik, Anders Batman Mjelle, Steinar Hunskaar
OBJECTIVES: Acute respiratory infections and fever among children are highly prevalent in primary care. It is challenging to distinguish between viral and bacterial infections. Norway has a relatively low prescription rate of antibiotics, but it is still regarded as too high as the antimicrobial resistance is increasing. The aim of the study was to identify predictors for prescribing antibiotics or referral to hospital among children. DESIGN: Secondary analysis of a randomised controlled study...
January 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28096251/healthcare-resource-consumption-for-intermittent-urinary-catheterisation-cost-effectiveness-of-hydrophilic-catheters-and-budget-impact-analyses
#6
Carla Rognoni, Rosanna Tarricone
OBJECTIVES: This study presents a cost-effectiveness analysis comparing hydrophilic coated to uncoated catheters for patients performing urinary intermittent catheterisation. A national budget impact analysis is also included to evaluate the impact of intermittent catheterisation for management of bladder dysfunctions over a period of 5 years. DESIGN: A Markov model (lifetime horizon, 1 year cycle length) was developed to project health outcomes (life years and quality-adjusted life years) and economic consequences related to patients using hydrophilic coated or uncoated catheters...
January 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28096102/nihr-clinical-research-networks-what-they-do-and-how-they-help-paediatric-research
#7
REVIEW
Hanna Lythgoe, Victoria Price, Vanessa Poustie, Sabah Attar, Daniel Hawcutt, Jennifer Preston, Michael W Beresford
This review provides paediatricians with an update on the new structure of the National Institute for Health Research's (NIHR) Clinical Research Network (CRN): Children and its role within the wider NIHR infrastructure. The network supports delivery of high-quality research within the NHS in England and supports researchers, through provision of staff and resources, with feasibility, site set-up, patient recruitment and study management. Since 2013, over 80% of commercial contract studies running within the UK sat within the UKCRN Portfolio...
January 17, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28096080/fto-genotype-and-weight-loss-systematic-review-and-meta-analysis-of-9563-individual-participant-data-from-eight-randomised-controlled-trials
#8
(no author information available yet)
No abstract text is available yet for this article.
January 17, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28096079/exercise-therapy-versus-arthroscopic-partial-meniscectomy-for-degenerative-meniscal-tear-in-middle-aged-patients-randomised-controlled-trial-with-two-year-follow-up
#9
(no author information available yet)
No abstract text is available yet for this article.
January 17, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28095998/the-feasibility-and-clinical-benefits-of-improving-facial-affect-recognition-impairments-in-schizophrenia-systematic-review-and-meta-analysis
#10
REVIEW
Natalie Bordon, Suzanne O'Rourke, Paul Hutton
BACKGROUND: People diagnosed with schizophrenia have significant difficulty accurately recognising emotions expressed by others. This may generate anomalous experiences which, if misinterpreted, could contribute to experiences of social defeat, psychotic symptoms and reduced social functioning. It remains unclear whether this impairment is responsive to non-pharmacological intervention, or what the effect of modifying it is. METHODS: We did a systematic review and meta-analysis to examine whether and to what extent facial affect recognition impairments can be improved by psychological intervention and, if so, whether this leads to improvements in psychotic symptoms and social functioning...
January 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28095883/moderated-online-social-therapy-for-carers-of-young-people-recovering-from-first-episode-psychosis-study-protocol-for-a-randomised-controlled-trial
#11
John Gleeson, Reeva Lederman, Helen Herrman, Peter Koval, Dina Eleftheriadis, Sarah Bendall, Sue M Cotton, Mario Alvarez-Jimenez
BACKGROUND: First-episode psychosis most often has its onset during late adolescence. In caring for the young person, families endure high levels of stress and depression. Meanwhile, the social networks of families often erode. Our group has previously shown that family cognitive behaviour therapy (CBT) leads to significantly improved perceived stress compared with specialist first-episode treatment as usual; however, there are well-known barriers to the dissemination of effective family interventions...
January 17, 2017: Trials
https://www.readbyqxmd.com/read/28095832/cost-effectiveness-of-using-a-motion-sensor-biofeedback-treatment-approach-for-the-management-of-sub-acute-or-chronic-low-back-pain-economic-evaluation-alongside-a-randomised-trial
#12
Terry Haines, Kelly-Ann Bowles
BACKGROUND: Low back pain is a common and costly condition internationally. There is high need to identify effective and economically efficient means for managing this problem. This study aimed to explore the cost-effectiveness of a novel motion-sensor biofeedback treatment approach in addition to guidelines-based care compared to guidelines-based care alone, from a societal perspective over a 12 month time horizon. METHOD: This was an incremental cost-effectiveness analysis conducted concurrently with a pilot, cluster randomized controlled trial...
January 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28095827/lessons-learned-from-the-london-exercise-and-pregnant-leap-smokers-randomised-controlled-trial-process-evaluation-implications-for-the-design-of-physical-activity-for-smoking-cessation-interventions-during-pregnancy
#13
Nikoletta Giatras, Elisabeth Wanninkhof, Miranda Leontowitsch, Beth Lewis, Adrian Taylor, Sue Cooper, Michael Ussher
BACKGROUND: The challenges of delivering interventions for pregnant smokers have been poorly documented. Also, the process of promoting a physical activity intervention for pregnant smokers has not been previously recorded. This study describes the experiences of researchers conducting a randomised controlled trial of physical activity as an aid to smoking cessation during pregnancy and explores how the effectiveness of future interventions could be improved. METHODS: Two focus groups, with independent facilitators, were conducted with six researchers who had enrolled pregnant smokers in the LEAP trial, provided the interventions, and administered the research measures...
January 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28095821/weighing-as-a-stand-alone-intervention-does-not-reduce-excessive-gestational-weight-gain-compared-to-routine-antenatal-care-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#14
Shanna M Fealy, Rachael M Taylor, Maralyn Foureur, John Attia, Lyn Ebert, Alessandra Bisquera, Alexis J Hure
BACKGROUND: Excessive gestational weight gain is associated with short and long-term adverse maternal and infant health outcomes, independent of pre-pregnancy body mass index. Weighing pregnant women as a stand-alone intervention during antenatal visits is suggested to reduce pregnancy weight gain. In the absence of effective interventions to reduce excessive gestational gain within the real world setting, this study aims to test if routine weighing as a stand-alone intervention can reduce total pregnancy weight gain and, in particular, excessive gestational weight gain...
January 17, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28095801/providing-lipid-based-nutrient-supplement-during-pregnancy-does-not-reduce-the-risk-of-maternal-p-falciparum-parasitaemia-and-reproductive-tract-infections-a-randomised-controlled-trial
#15
Minyanga Nkhoma, Per Ashorn, Ulla Ashorn, Kathryn G Dewey, Austrida Gondwe, John Mbotwa, Stephen Rogerson, Steve M Taylor, Kenneth Maleta
BACKGROUND: Maternal infections are associated with maternal and foetal adverse outcomes. Nutrient supplementation during pregnancy may reduce the occurrence of infections by improving maternal immunity. We aimed to investigate the impact of small-quantity lipid-based nutrient supplement (SQ-LNS) on the occurrence of Plasmodium falciparum parasitaemia during pregnancy and trichomoniasis, vaginal candidiasis and urinary tract infection (UTI) after delivery. METHODS: Pregnant Malawian women enrolled in the iLiNS-DYAD trial receiving daily supplementation with SQ-LNS, multiple micronutrients (MMN) or iron & folic acid (IFA) from <20 gestation weeks (gw) were assessed for P...
January 17, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28095704/a-pilot-study-examining-the-effects-of-priming-headache-illness-schema-on-attentional-engagement-towards-pain-relief-medication-in-those-with-high-and-low-medication-treatment-beliefs
#16
Monisha Ahluwalia, Alicia M Hughes, Lance M McCracken, Joseph Chilcot
Few studies have assessed the underlying theoretical components of the Common Sense Model. Past studies have found, through implicit priming, that coping strategies are embedded within illness schema. Our aim was to evaluate the effect priming 'headache' illness schema upon attentional engagement to pain relief medication and to examine the interaction with illness treatment beliefs. Attentional engagement to the pain relief medication ('Paracetamol') was assessed using a 2 (primed vs. control) × 2 (strong belief in medication efficacy vs...
January 18, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28095412/intensive-versus-guideline-blood-pressure-and-lipid-lowering-in-patients-with-previous-stroke-main-results-from-the-pilot-prevention-of-decline-in-cognition-after-stroke-trial-podcast-randomised-controlled-trial
#17
Philip M Bath, Polly Scutt, Daniel J Blackburn, Sandeep Ankolekar, Kailash Krishnan, Clive Ballard, Alistair Burns, Jonathan Mant, Peter Passmore, Stuart Pocock, John Reckless, Nikola Sprigg, Rob Stewart, Joanna M Wardlaw, Gary A Ford
BACKGROUND: Stroke is associated with the development of cognitive impairment and dementia. We assessed the effect of intensive blood pressure (BP) and/or lipid lowering on cognitive outcomes in patients with recent stroke in a pilot trial. METHODS: In a multicentre, partial-factorial trial, patients with recent stroke, absence of dementia, and systolic BP (SBP) 125-170 mmHg were assigned randomly to at least 6 months of intensive (target SBP <125 mmHg) or guideline (target SBP <140 mmHg) BP lowering...
2017: PloS One
https://www.readbyqxmd.com/read/28094851/blood-transfusion-for-preventing-primary-and-secondary-stroke-in-people-with-sickle-cell-disease
#18
REVIEW
Lise J Estcourt, Patricia M Fortin, Sally Hopewell, Marialena Trivella, Winfred C Wang
BACKGROUND: Sickle cell disease is one of the commonest severe monogenic disorders in the world, due to the inheritance of two abnormal haemoglobin (beta globin) genes. Sickle cell disease can cause severe pain, significant end-organ damage, pulmonary complications, and premature death. Stroke affects around 10% of children with sickle cell anaemia (HbSS). Chronic blood transfusions may reduce the risk of vaso-occlusion and stroke by diluting the proportion of sickled cells in the circulation...
January 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28094472/outpatient-60-hour%C3%A2-day-and-night%C3%A2-glucose-control-with-dual-hormone%C3%A2-artificial-pancreas-single-hormone-artificial-pancreas-%C3%A2-or-sensor-augmented-pump-therapy-in-adults-with%C3%A2-type-1-diabetes-an-open-label-%C3%A2-randomised-crossover-controlled-trial
#19
Ahmad Haidar, Virginie Messier, Laurent Legault, Martin Ladouceur, Rémi Rabasa-Lhoret
AIMS: To assess whether the dual-hormone (insulin and glucagon) artificial pancreas reduces hypoglycemia compared to the single-hormone (insulin alone) artificial pancreas in outpatient settings during the day and night. MATERIAL AND METHODS: In a randomized, three-way, crossover trial, we compared the dual-hormone artificial pancreas, the single-hormone artificial pancreas, and sensor-augmented pump therapy (control) in 23 adults with type 1 diabetes. Each intervention was applied from 08 h00 Day 1 to 20 h00 Day 3 (60 hours) in outpatient free-living conditions...
January 17, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28094468/long-term-outcomes-of-transobturator-tapes-in-women-with-stress-urinary-incontinence-e-tot-randomised-controlled-trial
#20
Debjyoti Karmakar, Alyaa Mostafa, Mohamed Abdel-Fattah
OBJECTIVES: To assess the long-term (LT) patient-reported outcomes and adverse events(AE) following transobturator tension-free vaginal tape(TO-TVT). DESIGN: Postal follow-up of the E-TOT randomised controlled trial(RCT). SETTING: A tertiary urogynaecology center in the UK; all procedures took place in 2005 to2007. POPULATION: 341 Women were randomised to undergo either "inside-out" TVT-O (Ethicon Inc.,Somerville,NJ,USA) or "outside-in" TOT-ARIS (Coloplast Corp...
January 17, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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