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https://www.readbyqxmd.com/read/28742263/progesterone-receptor-modulators-for-endometriosis
#1
REVIEW
Jing Fu, Hao Song, Min Zhou, Huili Zhu, Yuhe Wang, Hengxi Chen, Wei Huang
BACKGROUND: Endometriosis is defined as the presence of endometrial tissue (glands and stroma) outside the uterine cavity. This condition is oestrogen-dependent and thus is seen primarily during the reproductive years. Owing to their antiproliferative effects in the endometrium, progesterone receptor modulators (PRMs) have been advocated for treatment of endometriosis. OBJECTIVES: To assess the effectiveness and safety of PRMs primarily in terms of pain relief as compared with other treatments or placebo or no treatment in women of reproductive age with endometriosis...
July 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28742262/bladder-neck-needle-suspension-for-urinary-incontinence-in-women
#2
REVIEW
Cathryn Ma Glazener, Kevin Cooper, Atefeh Mashayekhi
BACKGROUND: Bladder neck needle suspension is an operation traditionally used for moderate or severe stress urinary incontinence in women. About a third of adult women experience some urinary incontinence, and about a third of these have moderate or severe symptoms. Stress urinary incontinence (SUI) imposes significant health and economic burdens on society and the women affected. OBJECTIVES: To determine the effects of needle suspension on stress or mixed urinary incontinence in comparison with other management options...
July 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28742235/silver-delivery-approaches-in-the-management-of-partial-thickness-burns-a-systematic-review-and-indirect-treatment-comparison
#3
Leo Nherera, Paul Trueman, Christopher Roberts, Leena Berg
Silver-containing products play an important role in the management of burn wound infections. We sought to compare the efficacy of commonly used silver delivery approaches including nanocrystalline silver, silver-impregnated hydrofiber dressing, and silver-impregnated foam dressing as the main products in the management of partial thickness burns. A systematic review was performed by searching PubMed, EMBASE, Cochrane and other databases to identify relevant randomised controlled trials and observational studies...
July 25, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28741683/a-clinical-trial-of-a-novel-emulsion-for-potential-use-as-a-saliva-substitute-in-patients-with-radiation-induced-xerostomia
#4
Olivia Apperley, Natalie Medlicott, Alison Rich, Sara Hanning, Maggie-Lee Huckabee
AIM: Researchers have recently developed a novel oily formulation for potential use as a saliva substitute for the treatment of dry mouth. The aim of this randomised, cross-over study was to compare this new formulation to a currently available saliva substitute and a control of water on measures of mastication, subjective feeling of oral dryness and product acceptability. METHODS: Forty participants treated with radiotherapy to the head and neck and experiencing xerostomia were invited to participate in the trial...
July 25, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28741653/a-randomised-controlled-trial-of-oral-chloral-hydrate-vs-intranasal-dexmedetomidine-before-computerised-tomography-in-children
#5
V M Yuen, B L Li, D K Cheuk, M K M Leung, T W C Hui, I C Wong, W W Lam, S W Choi, M G Irwin
Chloral hydrate is commonly used to sedate children for painless procedures. Children may recover more quickly after sedation with dexmedetomidine, which has a shorter half-life. We randomly allocated 196 children to chloral hydrate syrup 50 mg.kg(-1) and intranasal saline spray, or placebo syrup and intranasal dexmedetomidine spray 3 μg.kg(-1) , 30 min before computerised tomography studies. More children resisted or cried after drinking chloral hydrate syrup than placebo syrup, 72 of 107 (67%) vs. 42 of 87 (48%), p = 0...
July 25, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28741652/a-randomised-controlled-trial-of-rectus-sheath-bupivacaine-and-intrathecal-bupivacaine-without-or-with-intrathecal-morphine-vs-intrathecal-bupivacaine-and-morphine-after-caesarean-section
#6
M W Lui, T K T Li, F Lui, C Y T Ong
We recruited 144 women of whom 131 underwent scheduled caesarean section and were allocated to intrathecal bupivacaine without (46) or with (47) morphine and postoperative rectus sheath bupivacaine; or intrathecal bupivacaine with morphine and postoperative rectus sheath saline (38). We measured postoperative pain with a 10-point numeric rating scale. The mean (SD) areas under the curve for pain on movement during 48 postoperative hours were 273.5 (63.6), 223.8 (80.7) and 223.8 (80.7), respectively, p = 0.008...
July 25, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28741625/omega-3-polyunsaturated-fatty-acids-in-youths-with-attention-deficit-hyperactivity-disorder-adhd-a-systematic-review-and-meta-analysis-of-clinical-trials-and-biological-studies
#7
JanePei-Chen Chang, Kuan-Pin Su, Valeria Mondelli, Carmine M Pariante
The role of omega-3 polyunsaturated fatty acids (omega-3 or n-3 PUFAs) in the pathogenesis and treatment of children and adolescents with attention deficit hyperactivity disorder (ADHD) is unclear. A systematic review followed by meta-analysis was conducted on: (1) randomized controlled trials (RCTs) assessing the effects of n-3 PUFAs on clinical symptoms and cognition in children and adolescent with ADHD; and (2) case-control studies assessing the levels of n-3 PUFAs in blood and buccal tissues of children and adolescents with ADHD...
July 25, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28741390/maternal-haemoglobin-concentration-and-risk-of-preterm-birth-in-a-chinese-population
#8
Yiting Zhang, Zhiwen Li, Hongtian Li, Lei Jin, Yali Zhang, Le Zhang, Jufen Liu, Rongwei Ye, Jianmeng Liu, Aiguo Ren
The aim was to examine the relationship between maternal haemoglobin (Hb) concentrations and risk of preterm birth by secondary analysis of data from a randomised controlled trial. This analysis included 10,430 women who were at least 20 years old and no more than 20 weeks of gestation. Results revealed neither first- nor second-trimester Hb concentrations were associated with the risk of preterm births. However, the risk of preterm birth increased when the Hb level was low (<130 g/L) in the first but high (≥130 g/L) in the second trimester, regardless of supplement type (iron-containing: AOR: 2...
July 25, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28741303/open-retropubic-colposuspension-for-urinary-incontinence-in-women
#9
REVIEW
Marie Carmela M Lapitan, June D Cody, Atefeh Mashayekhi
BACKGROUND: Urinary incontinence is a common and potentially debilitating problem. Stress urinary, incontinence as the most common type of incontinence, imposes significant health and economic burdens on society and the women affected. Open retropubic colposuspension is a surgical treatment which involves lifting the tissues near the bladder neck and proximal urethra in the area behind the anterior pubic bones to correct deficient urethral closure to correct stress urinary incontinence...
July 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28741176/safety-and-feasibility-of-exercise-interventions-in-patients-with-advanced-cancer-a-systematic-review
#10
REVIEW
Reginald Heywood, Alexandra L McCarthy, Tina L Skinner
GOALS OF WORK: The beneficial effects of exercise in cancer patients are reasonably well-established, although research in this field has predominantly investigated cancer patients in the earlier stages of disease. However, the most recent evidence surrounding exercise interventions in advanced cancer populations has yet to be systematically evaluated. This review critically analyses the safety and feasibility of exercise interventions in patients with advanced cancer. METHODS: All randomised, non-randomised and prospective observational trials of exercise training interventions in patients with advanced cancer were included...
July 25, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28741134/a-cluster-randomised-trial-to-determine-the-efficacy-of-the-feeding-buddies-programme-in-improving-exclusive-breastfeeding-rates-among-hiv-infected-women-in-rural-kwazulu-natal-south-africa
#11
Penelope Reimers, Kiersten Israel-Ballard, Marlies Craig, Lenore Spies, Ibou Thior, Frank Tanser, Anna Coutsoudis
This cluster randomised trial in KwaZulu-Natal South Africa, evaluated the implementation of a Feeding Buddies (FB) programme to improve exclusive breastfeeding (EBF) amongst human immunodeficiency virus infected mothers. Eight clinics were randomly allocated to intervention and control arms respectively. Pregnant women attending the prevention of mother-to-child transmission program and intending to EBF were enrolled: control (n = 326), intervention (n = 299). Intervention mothers selected FBs to support them and they were trained together (four sessions)...
July 24, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28739536/time2bhealthy-an-online-childhood-obesity-prevention-program-for-preschool-aged-children-a-randomised-controlled-trial-protocol
#12
Megan L Hammersley, Rachel A Jones, Anthony D Okely
BACKGROUND: The use of parent-focused internet-based programs for the prevention and treatment of childhood obesity has shown promise but there is an acknowledged gap in parent-focused interventions which target the early childhood stage. METHODS: The aim of this study is to determine the efficacy of Time2bHealthy - an online healthy lifestyle program for parents of preschool-aged children. The program will be evaluated using a two-arm, parallel, randomised controlled design...
July 21, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28739443/sauna-exposure-immediately-prior-to-short-term-heat-acclimation-accelerates-phenotypic-adaptation-in-females
#13
Jessica A Mee, Sophie Peters, Jonathan H Doust, Neil S Maxwell
OBJECTIVES: Investigate whether a sauna exposure prior to short-term heat acclimation (HA) accelerates phenotypic adaptation in females. DESIGN: Randomised, repeated measures, cross-over trial. METHODS: Nine females performed two 5-d HA interventions (controlled hyperthermia Tre≥38.5°C), separated by 7-wk, during the follicular phase of the menstrual cycle confirmed by plasma concentrations of 17-β estradiol and progesterone. Prior to each 90-min HA session participants sat for 20-min in either a temperate environment (20°C, 40% RH; HAtemp) wearing shorts and sports bra or a hot environment (50°C, 30% RH) wearing a sauna suit to replicate sauna conditions (HAsauna)...
July 4, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28739015/randomised-controlled-trials-remain-the-key-to-progress-in-localised-prostate-cancer
#14
EDITORIAL
Alison Tree, David Dearnaley
No abstract text is available yet for this article.
July 21, 2017: European Urology
https://www.readbyqxmd.com/read/28738912/changes-in-dietary-intake-following-a-culturally-adapted-lifestyle-intervention-among-iraqi-immigrants-to-sweden-at-high-risk-of-type-2-diabetes-a-randomised-trial
#15
Faiza Siddiqui, Vicky Winther, Azra Kurbasic, Emily Sonestedt, Katarina Balcker Lundgren, Staffan Lindeberg, Peter M Nilsson, Louise Bennet
OBJECTIVE: To investigate the effectiveness of a culturally adapted lifestyle intervention for changing dietary intake, particularly energy, fat and fibre intakes, in the intervention group (IG) compared with the control group (CG). DESIGN: Randomised controlled trial. SETTING: IG (n 50) and CG (n 46). The IG was offered seven group sessions, including one cooking class, over a period of 4 months. The participants filled out 4 d food diaries at the start, mid and end of the study...
July 25, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28738794/escaschool-study-trial-protocol-of-an-adaptive-treatment-approach-for-school-age-children-with-adhd-including-two-randomised-trials
#16
Manfred Döpfner, Christopher Hautmann, Christina Dose, Tobias Banaschewski, Katja Becker, Daniel Brandeis, Martin Holtmann, Thomas Jans, Carolin Jenkner, Sabina Millenet, Tobias Renner, Marcel Romanos, Elena von Wirth
BACKGROUND: The ESCAschool study addresses the treatment of school-age children with attention-deficit/hyperactivity disorder (ADHD) in a large multicentre trial. It aims to investigate three interrelated topics: (i) Clinical guidelines often recommend a stepped care approach, including different treatment strategies for children with mild to moderate and severe ADHD symptoms, respectively. However, this approach has not yet been empirically validated. (ii) Behavioural interventions and neurofeedback have been shown to be effective, but the superiority of combined treatment approaches such as medication plus behaviour therapy or medication plus neurofeedback compared to medication alone remains questionable...
July 24, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28738781/the-value-of-a-new-cardiac-magnetic-resonance-imaging-protocol-in-myocardial-infarction-with-non-obstructive-coronary-arteries-minoca-a-case-control-study-using-historical-controls-from-a-previous-study-with-similar-inclusion-criteria
#17
Per Tornvall, E B Brolin, K Caidahl, K Cederlund, O Collste, M Daniel, C Ekenbäck, J Jensen, S Y-Hassan, L Henareh, C Hofman-Bang, P Lyngå, E Maret, N Sarkar, J Spaak, M Sundqvist, P Sörensson, M Ugander, S Agewall
BACKGROUND: Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) is common with a prevalence of 6% of all patients fulfilling the diagnosis of myocardial infarction. MINOCA should be considered a working diagnosis. Cardiac Magnetic Resonance (CMR) imaging has recently been suggested to be of great value to determine the cause behind MINOCA. The objectives of this paper are to describe the rationale behind the second Stockholm Myocardial Infarction with Normal Coronaries (SMINC-2) study and to discuss the protocol for investigation of MINOCA patients in the light of the recently published position paper from the European Society of Cardiology...
July 24, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28738443/urethral-injection-therapy-for-urinary-incontinence-in-women
#18
REVIEW
Vivienne Kirchin, Tobias Page, Phil E Keegan, Kofi Om Atiemo, June D Cody, Samuel McClinton, Patricia Aluko
BACKGROUND: Urinary incontinence imposes a significant health and economic burden to society. Periurethral or transurethral injection of bulking agents is a minimally invasive surgical procedure used as one the surgical treatments of stress urinary incontinence (SUI) in adult women. OBJECTIVES: To assess the effects of periurethral or transurethral injection therapy on the cure or improvement of urinary incontinence in women. SEARCH METHODS: We searched the Cochrane Incontinence Group Specialised Trials Register (searched 8 November 2010) and the reference lists of relevant articles...
July 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28738295/does-the-effect-of-one-day-simulation-team-training-in-obstetric-emergencies-decline-within-one-year-a-post-hoc-analysis-of-a-multicentre-cluster-randomised-controlled-trial
#19
J van de Ven, A F Fransen, E Schuit, P J van Runnard Heimel, B W Mol, S G Oei
Does the effect of one-day simulation team training in obstetric emergencies decline within one year? A post-hoc analysis of a multicentre cluster randomised controlled trial. J van de Ven, AF Fransen, E Schuit, PJ van Runnard Heimel, BW Mol, SG Oei OBJECTIVE: To investigate whether the effect of a one-day simulation-based obstetric team training on patient outcome changes over time. STUDY DESIGN: Post-hoc analysis of a multicentre, open, randomised controlled trial that evaluated team training in obstetrics (TOSTI study)...
July 14, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28738257/a-systematic-review-of-the-quality-of-statistical-methods-employed-for-analysing-quality-of-life-data-in-cancer-randomised-controlled-trials
#20
REVIEW
Jean-Francois Hamel, Patrick Saulnier, Madeline Pe, Efstathios Zikos, Jammbe Musoro, Corneel Coens, Andrew Bottomley
AIMS: Over the last decades, Health-related Quality of Life (HRQoL) end-points have become an important outcome of the randomised controlled trials (RCTs). HRQoL methodology in RCTs has improved following international consensus recommendations. However, no international recommendations exist concerning the statistical analysis of such data. The aim of our study was to identify and characterise the quality of the statistical methods commonly used for analysing HRQoL data in cancer RCTs...
July 21, 2017: European Journal of Cancer
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