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https://www.readbyqxmd.com/read/29351130/comparative-effectiveness-of-low-volume-time-efficient-resistance-training-versus-endurance-training-in-patients-with-heart-failure
#1
Gregers Winding Munch, Jaya Birgitte Rosenmeier, Morten Petersen, Anders Rasmussen Rinnov, Ulrik Winning Iepsen, Bente Klarlund Pedersen, Stefan Peter Mortensen
PURPOSE: Cardiorespiratory fitness is positively related to heart failure (HF) prognosis, but lack of time and low energy are barriers for adherence to exercise. We, therefore, compared the effect of low-volume time-based resistance exercise training (TRE) with aerobic moderate-intensity cycling (AMC) on maximal and submaximal exercise capacity, health-related quality of life, and vascular function. METHODS: Twenty-eight HF patients (New York Heart Association class I-II) performed AMC (n = 14) or TRE (n = 14)...
January 18, 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29349633/effects-of-tetradecylthioacetic-acid-tta-treatment-on-lipid-metabolism-in-salmon-hearts-in-vitro-and-in-vivo-studies
#2
Regin Arge, Jens-Erik Dessen, Tone-Kari Østbye, Bente Ruyter, Magny S Thomassen, Kjell-Arne Rørvik
In intensive farming of Atlantic salmon, a large proportion of observed mortality is related to cardiovascular diseases and circulatory failure, indicating insufficient robustness and inadequate cardiac performance. This paper reports on the use of tetradecylthioacetic acid (TTA) where the main objective was to enhance utilisation of fatty acids (FA), considered the main energy source of the heart. In this study, three experiments were conducted: (I) an in vivo study where salmon post-smolt were administrated dietary TTA in sea, (II) an in vitro study where isolated salmon heart cells were pre-stimulated with increasing doses of TTA and (III) an in vivo experiment where salmon post-smolt were subjected to injections with increasing doses of TTA...
January 19, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29347574/emergence-of-biaxial-nematic-phases-in-solutions-of-semiflexible-dimers
#3
Arvin Vaghela, Paulo I C Teixeira, Eugene M Terentjev
We investigate the isotropic, uniaxial nematic and biaxial nematic phases, and the transitions between them, for a model lyotropic mixture of flexible molecules consisting of two rigid rods connected by a spacer with variable bending stiffness. We apply density-functional theory within the Onsager approximation to describe strictly excluded-volume interactions in this athermal model and to self-consistently find the orientational order parameters dictated by its complex symmetry, as functions of the density...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347367/elastic-and-viscous-properties-of-the-nematic-dimer-cb7cb
#4
Greta Babakhanova, Zeinab Parsouzi, Sathyanarayana Paladugu, Hao Wang, Yu A Nastishin, Sergij V Shiyanovskii, Samuel Sprunt, Oleg D Lavrentovich
We present a comprehensive set of measurements of optical, dielectric, diamagnetic, elastic, and viscous properties in the nematic (N) phase formed by a liquid crystalline dimer. The studied dimer, 1,7-bis-4-(4'-cyanobiphenyl) heptane (CB7CB), is composed of two rigid rodlike cyanobiphenyl segments connected by a flexible aliphatic link with seven methyl groups. CB7CB and other nematic dimers are of interest due to their tendency to adopt bent configurations and to form two states possessing a modulated nematic director structure, namely, the twist-bend nematic, N_{TB}, and the oblique helicoidal cholesteric, Ch_{OH}, which occurs when the achiral dimer is doped with a chiral additive and exposed to an external electric or magnetic field...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347294/-13-c-nmr-study-of-the-director-distribution-adopted-by-the-modulated-nematic-phases-formed-by-liquid-crystal-dimers-with-odd-numbers-of-atoms-in-their-spacers
#5
J W Emsley, M Lelli, G R Luckhurst, H Zimmermann
The orientational order of the molecules in the bent mesogen CB6OCB has been studied throughout the range of temperature stability of both the N_{U} and N_{TB} liquid-crystal phases by ^{13}C NMR spectroscopy. These spectra provide local order parameters for the para axes of both of the nonequivalent cyanobiphenyl groups and show how they change on entering the twist-bend nematic phase. A key feature of the order parameters is a weak, but clear maximum in the temperature variation of the order parameter prior to the N_{TB} phase...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29343856/deep-ultraviolet-algan-aln-core-shell-multiple-quantum-wells-on-aln-nanorods-via-lithography-free-method
#6
Jinwan Kim, Uiho Choi, Jaedo Pyeon, Byeongchan So, Okhyun Nam
We report deep ultraviolet (UVC) emitting core-shell-type AlGaN/AlN multiple quantum wells (MQWs) on the AlN nanorods which are prepared by catalyst/lithography free process. The MQWs are grown on AlN nanorods on a sapphire substrate by polarity-selective epitaxy and etching (PSEE) using high-temperature metal organic chemical vapor deposition. The AlN nanorods prepared through PSEE have a low dislocation density because edge dislocations are bent toward neighboring N-polar AlN domains. The core-shell-type MQWs grown on AlN nanorods have three crystallographic orientations, and the final shape of the grown structure is explained by a ball-and-stick model...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343266/identification-of-pain-categories-associated-with-change-in-pain-in-patients-receiving-placebo-data-from-two-phase-3-randomized-clinical-trials-in-symptomatic-knee-osteoarthritis
#7
Asger Reinstrup Bihlet, Inger Byrjalsen, Anne-Christine Bay-Jensen, Jeppe Ragnar Andersen, Claus Christiansen, Bente Juel Riis, Ivo Valter, Morten A Karsdal, Marc C Hochberg
BACKGROUND: Pain is the principal clinical symptom of osteoarthritis (OA), and development of safe and effective analgesics for OA pain is needed. Drug development of new analgesics for OA pain is impaired by substantial change in pain in patients receiving placebo, and more data describing clinical characteristics and pain categories particularly associated with this phenomenon is needed. The purpose of this post-hoc analysis was to investigate clinical characteristics and pain categories and their association with radiographic progression and placebo pain reduction (PPR) in OA patients as measured the Western Ontario and McMasters Arthritis (WOMAC)...
January 17, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29342196/low-fitness-is-associated-with-abdominal-adiposity-and-low-grade-inflammation-independent-of-bmi
#8
Anne-Sophie Wedell-Neergaard, Louise Eriksen, Morten Grønbæk, Bente Klarlund Pedersen, Rikke Krogh-Madsen, Janne Tolstrup
OBJECTIVE: Up to 30% of obese individuals are metabolically healthy. Metabolically healthy obese (MHO) individuals are characterized by having low abdominal adiposity, low inflammation level and low risk of developing metabolic comorbidity. In this study, we hypothesize that cardiorespiratory fitness (fitness) is a determinant factor for the MHO individuals and aim to investigate the associations between fitness, abdominal adiposity and low-grade inflammation within different BMI categories...
2018: PloS One
https://www.readbyqxmd.com/read/29342149/low-expression-of-il-18-and-il-18-receptor-in-human-skeletal-muscle-is-associated-with-systemic-and-intramuscular-lipid-metabolism-role-of-hiv-lipodystrophy
#9
Birgitte Lindegaard, Thine Hvid, Helene Wolsk Mygind, Ole Hartvig-Mortensen, Thomas Grøndal, Julie Abildgaard, Jan Gerstoft, Bente Klarlund Pedersen, Marcin Baranowski
INTRODUCTION: Interleukin (IL)-18 is involved in regulation of lipid and glucose metabolism. Mice lacking whole-body IL-18 signalling are prone to develop weight gain and insulin resistance, a phenotype which is associated with impaired fat oxidation and ectopic skeletal muscle lipid deposition. IL-18 mRNA is expressed in human skeletal muscle but a role for IL-18 in muscle has not been identified. Patients with HIV-infection and lipodystrophy (LD) are characterized by lipid and glucose disturbances and increased levels of circulating IL-18...
2018: PloS One
https://www.readbyqxmd.com/read/29341672/helicase-stepping-investigated-with-one-nucleotide-resolution-fluorescence-resonance-energy-transfer
#10
Wenxia Lin, Jianbing Ma, Daguan Nong, Chunhua Xu, Bo Zhang, Jinghua Li, Qi Jia, Shuoxing Dou, Fangfu Ye, Xuguang Xi, Ying Lu, Ming Li
Single-molecule Förster resonance energy transfer is widely applied to study helicases by detecting distance changes between a pair of dyes anchored to overhangs of a forked DNA. However, it has been lacking single-base pair (1-bp) resolution required for revealing stepping kinetics of helicases. We designed a nanotensioner in which a short DNA is bent to exert force on the overhangs, just as in optical or magnetic tweezers. The strategy improved the resolution of Förster resonance energy transfer to 0.5 bp, high enough to uncover differences in DNA unwinding by yeast Pif1 and E...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341175/investigation-of-the-axial-gap-clearance-in-a-hydrodynamic-passive-magnetically-levitated-rotary-blood-pump-using-x-ray-radiography
#11
Bente Thamsen, Mathieu Plamondon, Marcus Granegger, Marianne Schmid Daners, Rolf Kaufmann, Antonia Neels, Mirko Meboldt
The HeartWare HVAD is a radial rotary blood pump with a combination of passive magnetic and hydrodynamic bearings to levitate the impeller. The axial gap size between impeller and housing in this bearing and its sensitivity to speed, flow, and pressure difference is difficult to assess. Shear stresses are exceptionally high in this tiny gap making it important for blood damage and related adverse events. Therefore, the aim of this study was to measure the axial gap clearance in the HVAD at different operating conditions employing radiography...
January 17, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29336349/nanodoping-a-route-for-enhancing-electro-optic-performance-of-bent-core-nematic-system
#12
Pradeep Kumar, Somen Debnath, Nandiraju V S Rao, Aloka Sinha
We report the effect of dispersion of barium titanate (BaTiO<sub>3</sub>) nanoparticles (BNPs) in a four ring bent core nematic (BCN) liquid crystal.Polarizing optical microscopy (POM) reveals the presence of a single nematic phase in pure and doped states. Polar switching has been observed in the bent core system and the value of spontaneous polarization (Ps) increases with increase in doping concentration of BNPs in BCN. Dielectric study shows a lower frequency mode, which can be ascribed to the formation of cybotactic clusters...
January 16, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29336155/highly-bendable-flexible-perovskite-solar-cells-on-a-nanoscale-surface-oxide-layer-of-titanium-metal-plates
#13
Gill Sang Han, Seongha Lee, Matthew Duff, Fen Qin, Jung-Kun Lee
We report highly bendable and efficient perovskite solar cells (PSCs) that use thermally oxidized layer of Ti metal plate as an electron transport layer (ETL). The power conversion efficiency (PCE) of flexible PSCs reaches 14.9 % with short-circuit current density (Jsc) of 17.9 mA/cm2, open circuit voltage (Voc) of 1.09, and fill factor (ff) of 0.74. Moreover, the Ti metal based PSCs exhibit a superior fatigue resistance over ITO/PEC substrate. Flexible PSCs maintain 100 % of their initial PCE even after PSCs are bent 1000 times at the bending radius of 4 mm...
January 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29336090/microsphere-assemblies-via-phosphonate-monoester-coordination-chemistry
#14
Kamila J Bladek, Margaret E Reid, Hirotomo Nishihara, Farid Akhtar, Benjamin S Gelfand, George K H Shimizu
By complexing a bent phosphonate monoester ligand with cobalt(II), coupled with in situ ester hydrolysis, coordination microspheres (CALS=CALgary Sphere) are formed whereas the use of the phosphonic acid directly resulted in a sheet-like structure. Manipulation of the synthetic conditions gave spheres with different sizes, mechanical stabilities, and porosities. Time-dependent studies determined that the sphere formation likely occurred through the formation of a Co2+ and ligand chain that propagates in three dimensions through different sets of interactions...
January 16, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29335789/first-record-of-trypanosoma-dionisii-of-the-t-cruzi-clade-from-the-eastern-bent-winged-bat-miniopterus-fuliginosus-in-the-far-east
#15
Eliakunda Mafie, Fatema Hashem Rupa, Ai Takano, Kazuo Suzuki, Ken Maeda, Hiroshi Sato
Chiropteran mammals worldwide harbour trypanosomes (Euglenozoa: Kinetoplastea: Trypanosomatida) of the subgenus 'Schizotrypanum' in the classical sense. Latterly, these trypanosomes have been referred to as members of the 'Trypanosoma cruzi clade' as their phylogenetic relationships, structure and life cycle conform to T. cruzi, parasitising various terrestrial mammals as well as humans in Latin America. Little is known, however, about the trypanosome species in Asian bats. During a survey on Borrelia spp. in the Eastern bent-winged bat (Miniopterus fuliginosus) living in a cave in Wakayama Prefecture, Japan, incidental proliferation of trypanosomes was detected in two of 94 haemocultures...
January 15, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29335326/attendance-of-routine-childcare-visits-in-primary-care-for-children-of-mothers-with-depression-a-nationwide-population-based-cohort-study
#16
Bente Kjær Lyngsøe, Claus Høstrup Vestergaard, Dorte Rytter, Mogens Vestergaard, Trine Munk-Olsen, Bodil Hammer Bech
BACKGROUND: Depression is a common and potentially debilitating illness worldwide. Attendance to routine childcare appointments is a key point of interest in the effort to improve the health and care for families facing depression. AIM: To evaluate the association between maternal depression and offspring non-attendance to the Danish childcare and vaccination programme (CCP) for children from 0-5 years of age. The CCP consists of seven separate visits and several vaccinations...
January 15, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29332402/monitoring-antimicrobial-mechanisms-of-surface-immobilized-peptides-in-situ
#17
Minyu Xiao, Joshua Jasensky, Leanna L Foster, Kenichi Kuroda, Zhan Chen
Antimicrobial peptides (AMPs) free in solution can kill bacteria by disrupting bacterial cell membranes. Their modes of action have been extensively studied and various models ranging from Pore formation to Carpet-like mechanism were proposed. Surface immobilized AMPs have been used as coatings to kill bacteria and as sensors to capture bacteria, but the interaction mechanisms of surface immobilized AMPs and bacteria are not fully understood. In this research, an analytical platform, SFG-microscope, which is composed of a sum frequency generation (SFG) vibrational spectrometer and a fluorescence microscope, was used to probe molecular interactions between surface immobilized AMPs and bacteria in situ in real time at the solid/liquid interface...
January 15, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29331614/the-burden-of-stroke-mimics-present-and-future-projections
#18
Kashif Waqar Faiz, Angela Susan Labberton, Bente Thommessen, Ole Morten Rønning, Fredrik A Dahl, Mathias Barra
BACKGROUND AND PURPOSE: An increasing proportion of patients presenting with suspected stroke prove to have other conditions, often referred to as stroke mimics. The aim of this study was to present a projection of the number of hospitalized strokes, transient ischemic attacks (TIAs), and stroke mimics in Norway up to the year 2050 based on expected demographic changes, to estimate the burden of stroke mimics in the coming decades. MATERIALS AND METHODS: This prospective study included all admissions to the stroke unit of Akershus University Hospital from March 1, 2012, to February 28, 2013...
January 10, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29331602/a-cross-continental-analysis-of-weight-gain-psychiatric-diagnoses-and-medication-use-during-inpatient-psychiatric-treatment-the-international-study-on-physical-illness-in-mentally-ill
#19
Christina Engelke, Christian Lange-Asschenfeldt, Stephanie Peter, Kai G Kahl, Karel Frasch, Jens I Larsen, Graziella G Bickel, Bernhard Bork, Bent A Jacobsen, Signe O Wallenstein-Jensen, Christoph Lauber, Birthe Mogensen, Jørgen A Nielsen, Wulf Rössler, Kenji J Tsuchiya, Kristian L Toftegaard, Ulla A Andersen, Richard Uwakwe, Povl Munk-Jørgensen, Joachim Cordes
Weight gain among psychiatric inpatients is a widespread phenomenon. This change in body mass index (BMI) can be caused by several factors. Based on recent research, we assume the following factors are related to weight gain during psychiatric inpatient treatment: psychiatric medication, psychiatric diagnosis, sex, age, weight on admission and geographic region of treatment. 876 of originally recruited 2328 patients met the criteria for our analysis. Patients were recruited and examined in mental health care centres in Nigeria (N = 265), Japan (N = 145) and Western-Europe (Denmark, Germany and Switzerland; N = 466)...
December 22, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29330524/nf-%C3%AE%C2%BAb-inducing-kinase-is-a-therapeutic-target-for-systemic-lupus-erythematosus
#20
Hans D Brightbill, Eric Suto, Nicole Blaquiere, Nandhini Ramamoorthi, Swathi Sujatha-Bhaskar, Emily B Gogol, Georgette M Castanedo, Benjamin T Jackson, Youngsu C Kwon, Susan Haller, Justin Lesch, Karin Bents, Christine Everett, Pawan Bir Kohli, Sandra Linge, Laura Christian, Kathy Barrett, Allan Jaochico, Leonid M Berezhkovskiy, Peter W Fan, Zora Modrusan, Kelli Veliz, Michael J Townsend, Jason DeVoss, Adam R Johnson, Robert Godemann, Wyne P Lee, Cary D Austin, Brent S McKenzie, Jason A Hackney, James J Crawford, Steven T Staben, Moulay H Alaoui Ismaili, Lawren C Wu, Nico Ghilardi
NF-κB-inducing kinase (NIK) mediates non-canonical NF-κB signaling downstream of multiple TNF family members, including BAFF, TWEAK, CD40, and OX40, which are implicated in the pathogenesis of systemic lupus erythematosus (SLE). Here, we show that experimental lupus in NZB/W F1 mice can be treated with a highly selective and potent NIK small molecule inhibitor. Both in vitro as well as in vivo, NIK inhibition recapitulates the pharmacological effects of BAFF blockade, which is clinically efficacious in SLE...
January 12, 2018: Nature Communications
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