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https://www.readbyqxmd.com/read/28651314/stabilization-of-heavy-metals-in-soil-using-two-organo-bentonites
#1
Kai Yu, Jian Xu, Xiaohong Jiang, Cun Liu, Wesley McCall, Jinlong Lu
Stabilization of Cu, Zn, Cd, Hg, Cr and As in soil using tetramethylammonium (TMA) and dodecyltrimethylammonium (DTMA) modified bentonites (T-Bents and D-Bents) as amendments was investigated. Toxicity characteristic leaching procedure (TCLP) was used to quantify the metal mobility after soil treatment. The structural parameters of modified bentonites, including the BET surface area, basal spacing and zeta potential were obtained as a function of the TMA and DTMA loading at 40, 80, 120, 160 and 200% of the bentonite's cation exchange capacity, respectively...
June 20, 2017: Chemosphere
https://www.readbyqxmd.com/read/28650207/epicardial-pericardial-and-total-cardiac-fat-and-cardiovascular-disease-in-type-2-diabetic-patients-with-elevated-urinary-albumin-excretion-rate
#2
Regitse H Christensen, Bernt J von Scholten, Christian S Hansen, Sarah E Heywood, Jaya B Rosenmeier, Ulrik B Andersen, Peter Hovind, Henrik Reinhard, Hans-Henrik Parving, Bente K Pedersen, Marit E Jørgensen, Peter K Jacobsen, Peter Rossing
Background We evaluated the association of cardiac adipose tissue including epicardial adipose tissue and pericardial adipose tissue with incident cardiovascular disease and mortality, coronary artery calcium, carotid intima media thickness and inflammatory markers. Design A prospective study of 200 patients with type 2 diabetes and elevated urinary albumin excretion rate (UAER). Methods Cardiac adipose tissue was measured from baseline echocardiography. The composite endpoint comprised incident cardiovascular disease and all-cause mortality...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28648619/nuclear-import-of-glucokinase-in-pancreatic-beta-cells-is-mediated-by-a-nuclear-localization-signal-and-modulated-by-sumoylation
#3
Bente Berg Johansson, Karianne Fjeld, Marie Holm Solheim, Jun Shirakawa, Enming Zhang, Magdalena Keindl, Jiang Hu, Andreas Lindqvist, Anne Døskeland, Gunnar Mellgren, Torgeir Flatmark, Pål Rasmus Njølstad, Rohit N Kulkarni, Nils Wierup, Ingvild Aukrust, Lise Bjørkhaug
The localization of glucokinase in pancreatic beta-cell nuclei is a controversial issue. Although previous reports suggest such a localization, the mechanism for its import has so far not been identified. Using immunofluorescence, subcellular fractionation and mass spectrometry, we here present evidence in support of glucokinase localization in beta-cell nuclei of human and mouse pancreatic sections, as well as in human and mouse isolated islets, and murine MIN6 cells. We have identified a conserved, seven-residue nuclear localization signal ((30)LKKVMRR(36)) in the human enzyme...
June 22, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28645967/the-bipolar-illness-onset-study-research-protocol-for-the-bio-cohort-study
#4
Lars Vedel Kessing, Klaus Munkholm, Maria Faurholt-Jepsen, Kamilla Woznica Miskowiak, Lars Bo Nielsen, Ruth Frikke-Schmidt, Claus Ekstrøm, Ole Winther, Bente Klarlund Pedersen, Henrik Enghusen Poulsen, Roger S McIntyre, Flavio Kapczinski, Wagner F Gattaz, Jakob Bardram, Mads Frost, Oscar Mayora, Gitte Moos Knudsen, Mary Phillips, Maj Vinberg
INTRODUCTION: Bipolar disorder is an often disabling mental illness with a lifetime prevalence of 1%-2%, a high risk of recurrence of manic and depressive episodes, a lifelong elevated risk of suicide and a substantial heritability. The course of illness is frequently characterised by progressive shortening of interepisode intervals with each recurrence and increasing cognitive dysfunction in a subset of individuals with this condition. Clinically, diagnostic boundaries between bipolar disorder and other psychiatric disorders such as unipolar depression are unclear although pharmacological and psychological treatment strategies differ substantially...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645602/clinical-application-of-insertion-force-sensor-system-for-coil-embolization-of-intracranial-aneurysms
#5
Noriaki Matsubara, Shigeru Miyachi, Takashi Izumi, Hiroyuki Yamada, Naoki Marui, Keisuke Ota, Hayato Tajima, Kazunori Shintai, Masashi Ito, Tasuku Imai, Masahiro Nishihori, Toshihiko Wakabayashi
INTRODUCTION: In endovascular embolization for intracranial aneurysms, it is important to properly control the coil insertion force. However, the force can only be subjectively detected by the subtle feedback experienced by the neurointerventionists at their fingertips. The authors envisioned a system that would objectively sense and quantify that force. In this article, coil insertion force was measured in cases of intracranial aneurysm using this sensor, and its actual clinical application was investigated...
June 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28645474/severe-mental-illness-and-clinical-outcome-after-primary-percutaneous-coronary-intervention
#6
Lars Jakobsen, Christian J Terkelsen, Evald H Christiansen, Michael Maeng, Lisette O Jensen, Karsten Veien, Bent Raungaard, Svend E Jensen, Frank Mehnert, Søren P Johnsen
The mechanisms behind the increased mortality in patients with acute myocardial infarction and co-existing severe mental illness (SMI) compared with non-SMI patients remain unclear. We studied 12,102 patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention, of whom 457 had SMI. The primary outcome was major adverse cardiac events (death, myocardial infarction, target vessel revascularization) at 30 days, 1 year, 2 years, and maximum follow-up. Patients with SMI were younger, more often women, had higher prevalence of active smoking and diabetes, and had a longer duration of symptoms than patients without SMI...
May 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28643390/oral-disorders-saliva-secretion-and-oral-health-related-quality-of-life-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#7
Shermin Rusthen, Alix Young, Bente B Herlofson, Lara A Aqrawi, Morten Rykke, Lene H Hove, Øyvind Palm, Janicke L Jensen, Preet B Singh
Chemosensory function, burning sensations in the tongue (BST), halitosis, saliva secretion, and oral health-related quality of life (OHRQoL) were investigated in patients with primary Sjögren's syndrome (pSS). In 31 patients with pSS and 33 controls, olfactory and gustatory functions were evaluated. Self-reported complaints of dysgeusia, BST, and halitosis were recorded. Saliva secretion rates were measured and OHRQoL was assessed using the short-form Oral Health Impact Profile (OHIP-14). Patients had significantly lower olfactory (8...
June 23, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/28643118/comparison-of-photon-organ-and-effective-dose-coefficients-for-pimal-stylized-phantom-in-bent-positions-in-standard-irradiation-geometries
#8
Shaheen Dewji, K Lisa Reed, Mauritius Hiller
Computational phantoms with articulated arms and legs have been constructed to enable the estimation of radiation dose in different postures. Through a graphical user interface, the Phantom wIth Moving Arms and Legs (PIMAL) version 4.1.0 software can be employed to articulate the posture of a phantom and generate a corresponding input deck for the Monte Carlo N-Particle (MCNP) radiation transport code. In this work, photon fluence-to-dose coefficients were computed using PIMAL to compare organ and effective doses for a stylized phantom in the standard upright position with those for phantoms in realistic work postures...
June 22, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28642222/risk-factors-for-head-injury-events-in-professional-rugby-union-a-video-analysis-of-464-head-injury-events-to-inform-proposed-injury-prevention-strategies
#9
Ross Tucker, Martin Raftery, Simon Kemp, James Brown, Gordon Fuller, Ben Hester, Matthew Cross, Ken Quarrie
OBJECTIVES: The tackle is responsible for the majority of head injuries during rugby union. In order to address head injury risk, risk factors during the tackle must first be identified. This study analysed tackle characteristics in the professional game in order to inform potential interventions. METHODS: 464 tackles resulting in a head injury assessment (HIA) were analysed in detail, with tackle type, direction, speed, acceleration, nature of head contact and player body position the characteristics of interest...
June 22, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28641432/local-structure-of-dilute-aqueous-dmso-solutions-as-seen-from-molecular-dynamics-simulations
#10
Abdenacer Idrissi, Bogdan A Marekha, Mohammed Barj, François Alexandre Miannay, Toshiyuki Takamuku, Vasilios Raptis, Jannis Samios, Pál Jedlovszky
The information about the structure of dimethyl sulfoxide (DMSO)-water mixtures at relatively low DMSO mole fractions is an important step in order to understand their cryoprotective properties as well as the solvation process of proteins and amino acids. Classical MD simulations, using the potential model combination that best reproduces the free energy of mixing of these compounds, are used to analyze the local structure of DMSO-water mixtures at DMSO mole fractions below 0.2. Significant changes in the local structure of DMSO are observed around the DMSO mole fraction of 0...
June 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28641301/fluoride-in-dental-biofilm-varies-across-intra-oral-regions
#11
Line Staun Larsen, Vibeke Baelum, Livia Maria Andaló Tenuta, Alan Richards, Bente Nyvad
Information on differences in biofilm fluoride concentration across intra-oral regions may help explain the distribution of caries within the dentition. The aim of this cross-sectional study was to describe the fluoride concentration in saliva and in biofilm fluid and biofilm solids across 6 intra-oral regions. Unstimulated whole saliva was collected from 42 participants and biofilm harvested from the buccal sites in the 4 molar and 2 anterior regions. Samples were collected at least 1 h after use of fluoride dentifrice...
June 23, 2017: Caries Research
https://www.readbyqxmd.com/read/28640942/polyfunctional-response-by-immtac-imcgp100-redirected-cd8-and-cd4-t-cells
#12
Caroline Boudousquie, Giovanna Bossi, Jacob M Hurst, Karolina A Rygiel, Bent K Jakobsen, Namir J Hassan
The success of immune system based cancer therapies depends on a broad immune response engaging a range of effector cells and mechanisms. Immune mobilising monoclonal TCRs against cancer (ImmTAC(™) molecules, fusion proteins consisting of a soluble, affinity enhanced TCR and an anti-CD3 scFv Ab) were previously shown to redirect CD8(+) and CD4(+) T cells against tumours. Here we present evidence that IMCgp100 (ImmTAC recognising a peptide derived from the melanoma-specific protein, gp100, presented by HLA-A*0201) efficiently redirects and activates effector and memory cells from both CD8(+) and CD4(+) repertoires...
June 22, 2017: Immunology
https://www.readbyqxmd.com/read/28640707/response-assessment-in-neuro-oncology-clinical-trials
#13
Patrick Y Wen, Susan M Chang, Martin J Van den Bent, Michael A Vogelbaum, David R Macdonald, Eudocia Q Lee
Development of novel therapies for CNS tumors requires reliable assessment of response and progression. This requirement has been particularly challenging in neuro-oncology for which contrast enhancement serves as an imperfect surrogate for tumor volume and is influenced by agents that affect vascular permeability, such as antiangiogenic therapies. In addition, most tumors have a nonenhancing component that can be difficult to accurately quantify. To improve the response assessment in neuro-oncology and to standardize the criteria that are used for different CNS tumors, the Response Assessment in Neuro-Oncology (RANO) working group was established...
June 22, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28640702/diffuse-infiltrating-oligodendroglioma-and-astrocytoma
#14
Martin J van den Bent, Marion Smits, Johan M Kros, Susan M Chang
The new 2016 WHO brain tumor classification defines different diffuse gliomas primarily according to the presence or absence of IDH mutations ( IDH-mt) and combined 1p/19q loss. Today, the diagnosis of anaplastic oligodendroglioma requires the presence of both IDH-mt and 1p/19q co-deletion, whereas anaplastic astrocytoma is divided into IDH wild-type ( IDH-wt) and IDH-mt tumors. IDH-mt tumors have a more favorable prognosis, and tumors with low-grade histology especially tend evolve slowly. IDH-wt tumors are not a homogeneous entity and warrant further molecular testing because some have glioblastoma-like molecular features with poor clinical outcome...
June 22, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28640616/the-twist-of-a-silicon-silicon-double-bond-selective-anti-addition-of-hydrogen-to-an-iminodisilene
#15
Daniel Wendel, Tibor Szilvási, Christian Jandl, Shigeyoshi Inoue, Bernhard Rieger
Hydrogenation of alkenes with C=C bonds is a ubiquitous reaction in organic chemistry. However, this transformation remains unknown for heavier counterparts, disilenes with Si=Si bonds. Here we report the isolation of (Z)-diiminodisilyldisilene 2 featuring a highly trans-bent and twisted structure and the longest silicon-silicon double bond reported to date. In silico studies suggested that the Si=Si bond in 2 is described as very weak double donor-acceptor bond. We utilized the remarkable electronic and structural features of this product to achieve the first demonstration of hydrogen activation by a multiply bonded silicon compound under ambient conditions...
June 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28640061/intermittent-standing-but-not-a-moderate-exercise-bout-reduces-postprandial-glycaemia
#16
Fabiana B Benatti, Sidsel A Larsen, Katja Kofoed, Signe T Nielsen, Nina M Harder-Lauridsen, Mark P Lyngbæk, Dorte Eriksen, Kristian Karstoft, Rikke Krogh-Madsen, Bente K Pedersen, Mathias Ried-Larsen
PURPOSE: To determine if minimum recommended moderate-to-vigorous physical activity (MVPA; 30-min bout of continuous moderate-intensity walking) is sufficient to counteract the detrimental effects of prolonged sitting on postprandial metabolism and if there are any effects of breaking up sitting with intermittent standing when achieving minimum recommended MVPA. METHODS: Fourteen (n=14) physically inactive healthy adult males underwent four intra-hospital 27-h interventions: 9-h continuous sitting (SIT); 15-min standing bouts every 30 min during the 9-h sitting (STAND); 30-min moderate-intensity walking bout followed by 8...
June 21, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28636607/three-dimensional-cell-shapes-and-arrangements-in-human-sweat-glands-as-revealed-by-whole-mount-immunostaining
#17
Ryuichiro Kurata, Sugiko Futaki, Itsuko Nakano, Fumitaka Fujita, Atsushi Tanemura, Hiroyuki Murota, Ichiro Katayama, Fumihiro Okada, Kiyotoshi Sekiguchi
Because sweat secretion is facilitated by mechanical contraction of sweat gland structures, understanding their structure-function relationship could lead to more effective treatments for patients with sweat gland disorders such as heat stroke. Conventional histological studies have shown that sweat glands are three-dimensionally coiled tubular structures consisting of ducts and secretory portions, although their detailed structural anatomy remains unclear. To better understand the details of the three-dimensional (3D) coiled structures of sweat glands, a whole-mount staining method was employed to visualize 3D coiled gland structures with sweat gland markers for ductal luminal, ductal basal, secretory luminal, and myoepithelial cells...
2017: PloS One
https://www.readbyqxmd.com/read/28636352/prevention-of-marine-biofouling-using-the-natural-allelopathic-compound-batatasin-iii-and-synthetic-analogues
#18
Lindon W K Moodie, Rozenn Trepos, Gunnar Cervin, Kari Anne Bråthen, Bente Lindgård, Rigmor Reiersen, Patrick Cahill, Henrik Pavia, Claire Hellio, Johan Svenson
The current study reports the first comprehensive evaluation of a class of allelopathic terrestrial natural products as antifoulants in a marine setting. To investigate the antifouling potential of the natural dihydrostilbene scaffold, a library of 22 synthetic dihydrostilbenes with varying substitution patterns, many of which occur naturally in terrestrial plants, were prepared and assessed for their antifouling capacity. The compounds were evaluated in an extensive screen against 16 fouling marine organisms...
June 21, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28633635/maternal-use-of-selective-serotonin-reuptake-inhibitors-during-pregnancy-is-associated-with-hirschsprung-s-disease-in-newborns-a-nationwide-cohort-study
#19
Sebastian Werngreen Nielsen, Perniller Møller Ljungdalh, Jan Nielsen, Bente Mertz Nørgård, Niels Qvist
BACKGROUND: Hirschsprung's disease is a rare condition caused by congenital malformation of the gastrointestinal tract affecting 1:5000 children. Not much is known about risk factors for development of Hirschsprung's disease. Two clinical cases of hirschsprung's disease led to an investigation of the association between maternal use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy and development of Hirschsprung's Disease in the newborn child. The study examined a nationwide, unselected cohort of children born in Denmark from 1 January 1996 until 12 March 2016 (n = 1,256,317)...
June 20, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28632657/role-of-computed-tomography-in-the-classification-of-pediatric-pelvic-fractures-revisited
#20
Melissa A Bent, William L Hennrikus, Johan E Latorre, Douglas G Armstrong, Brian Shaw, Kerwyn C Jones, Lee S Segal
OBJECTIVES: To determine the need for computerized tomography (CT) scans in the assessment of pediatric pelvic fractures. DESIGN: Retrospective Chart Review. SETTING: Level-1 Pediatric Trauma Center. PATIENTS/PARTICIPANTS: Thirty pediatric trauma patients with pelvic fractures who have obtained both a radiograph and CT scan. MAIN OUTCOME MEASUREMENTS: Fleiss Kappa coefficient to compare interreliability...
July 2017: Journal of Orthopaedic Trauma
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