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https://www.readbyqxmd.com/read/28535152/corrigendum-identification-and-evolution-of-a-plant-cell-wall-specific-glycoprotein-glycosyl-transferase-exad
#1
Svenning Rune Møller, Xueying Yi, Silvia Melina Velásquez, Sascha Gille, Pernille Louise Munke Hansen, Christian P Poulsen, Carl Erik Olsen, Martin Rejzek, Harriet Parsons, Zhang Yang, Hans H Wandall, Henrik Clausen, Robert A Field, Markus Pauly, Jose M Estevez, Jesper Harholt, Peter Ulvskov, Bent Larsen Petersen
This corrects the article DOI: 10.1038/srep45341.
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28534193/antagonist-perturbation-mechanism-for-activation-function-2-fixed-motifs-active-conformation-and-docking-mode-of-retinoid-x-receptor-antagonists
#2
Motonori Tsuji
HX531, which contains a dibenzodiazepine skeleton, is one of the first retinoid X receptor (RXR) antagonists. Functioning via RXR-PPARγ heterodimer, this compound is receiving a lot of attention as a therapeutic drug candidate for diabetic disease controlling differentiation of adipose tissue. However, the active conformation of HX531 for RXRs is not well established. In the present study, quantum mechanics calculations and molecular mechanical docking simulations were carried out to precisely study the docking mode of HX531 with the human RXRα ligand-binding domain, as well as to provide a new approach to drug design using a structure-based perspective...
May 22, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28532452/psychometric-properties-of-the-paindetect-questionnaire-in-rheumatoid-arthritis-psoriatic-arthritis-and-spondyloarthritis-rasch-analysis-and-test-retest-reliability
#3
Signe Rifbjerg-Madsen, Eva Ejlersen Wæhrens, Bente Danneskiold-Samsøe, Kirstine Amris
BACKGROUND: Pain is inherent in rheumatoid arthritis (RA), psoriatic arthritis (PsA) and spondyloarthritis (SpA) and traditionally considered to be of nociceptive origin. Emerging data suggest a potential role of augmented central pain mechanisms in subsets of patients, thus, valid instruments that can identify underlying pain mechanisms are needed. The painDETECT questionnaire (PDQ) was originally designed to differentiate between pain phenotypes. The objectives were to evaluate the psychometric properties of the PDQ in patients with inflammatory arthritis by applying Rasch analysis and to explore the reliability of pain classification by test-retest...
May 22, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28531177/geographical-trends-of-pfas-in-cod-livers-along-the-norwegian-coast
#4
Stig Valdersnes, Bente M Nilsen, Joar F Breivik, Asbjørn Borge, Amund Maage
The level of perfluorinated alkyl substances (PFAS) was determined in North East Arctic cod (Gadus morhua) liver samples from 15 Norwegian fjords and harbors. Five harbors in the eastern part of Norway, six harbors in the western part and four harbours in the northern part. A total of 200 samples were analyzed for 16 PFAS. Determination of PFAS were carried out by LC-MS/MS following sample clean up by solid phase extraction and ultracentrifugation. The predominating PFAS was PFOS, which was found to be higher than the level of quantification (1...
2017: PloS One
https://www.readbyqxmd.com/read/28530449/a-new-elastic-slot-system-and-v-wire-mechanics
#5
Andrea Wichelhaus
OBJECTIVE: To biomechanically test a new elastic slot system and V-wire mechanics. MATERIALS AND METHODS: Conventional twin and self-ligating brackets and the new elastodynamic bracket were biomechanically tested. The conventional brackets had a rectangular 0.022'' slot and the new elastodynamic bracket had a V-slot, a new slot geometry. Torque measurements were performed with 0.018'' × 0.025'' and 0.019'' × 0.025'' stainless steel (ss) archwires. A nickel-titanium V wire was used for the biomechanical measurements on the elastodynamic bracket...
May 22, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/28527865/mechanism-of-atrial-functional-mitral-regurgitation-in-patients-with-atrial-fibrillation-a-study-using-three-dimensional-transesophageal-echocardiography
#6
Kazato Ito, Yukio Abe, Yosuke Takahashi, Yoshihisa Shimada, Hitoshi Fukumoto, Yoshiki Matsumura, Takahiko Naruko, Toshihiko Shibata, Minoru Yoshiyama, Junichi Yoshikawa
BACKGROUND: Functional mitral regurgitation (MR) can occur in patients with atrial fibrillation (AF) despite having preserved left ventricular (LV) systolic function. This MR is known as atrial functional MR. The aim of this study was to clarify the mechanism of atrial functional MR using real-time three-dimensional transesophageal echocardiography (3DTEE). METHODS: Sixty patients underwent transthoracic echocardiography and 3DTEE: 16 patients with AF and significant non-organic MR and preserved LV ejection fraction (>50%) constituted the AF-MR group, 20 patients with AF and no significant MR formed the AF-NSMR group, and 24 normal subjects comprised the control group...
May 17, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28527437/ab-initio-study-of-the-neutral-and-anionic-alkali-and-alkaline-earth-hydroxides-electronic-structure-and-prospects-for-sympathetic-cooling-of-oh
#7
Milaim Kas, Jérôme Loreau, Jacques Liévin, Nathalie Vaeck
We have performed a systematic ab initio study on alkali and alkaline earth hydroxide neutral (MOH) and anionic (MOH(-)) species where M = Li, Na, K, Rb, Cs or Be, Mg, Ca, Sr, Ba. The CCSD(T) method with extended basis sets and Dirac-Fock relativistic effective core potentials for the heavier atoms has been used to study their equilibrium geometries, interaction energies, electron affinities, electric dipole moment, and potential energy surfaces. All neutral and anionic species exhibit a linear shape with the exception of BeOH, BeOH(-), and MgOH(-), for which the equilibrium structure is found to be bent...
May 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28526008/cleavage-of-the-urokinase-receptor-upar-on-oral-cancer-cells-regulation-by-transforming-growth-factor-%C3%AE-1-tgf-%C3%AE-1-and-potential-effects-on-migration-and-invasion
#8
Synnove Norvoll Magnussen, Elin Hadler-Olsen, Daniela Elena Costea, Eli Berg, Cristiane Cavalcanti Jacobsen, Bente Mortensen, Tuula Salo, Inigo Martinez-Zubiaurre, Jan-Olof Winberg, Lars Uhlin-Hansen, Gunbjorg Svineng
BACKGROUND: Urokinase plasminogen activator (uPA) receptor (uPAR) is up-regulated at the invasive tumour front of human oral squamous cell carcinoma (OSCC), indicating a role for uPAR in tumour progression. We previously observed elevated expression of uPAR at the tumour-stroma interface in a mouse model for OSCC, which was associated with increased proteolytic activity. The tumour microenvironment regulated uPAR expression, as well as its glycosylation and cleavage. Both full-length- and cleaved uPAR (uPAR (II-III)) are involved in highly regulated processes such as cell signalling, proliferation, migration, stem cell mobilization and invasion...
May 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28525579/modulation-of-cyclobutane-thymine-photodimer-formation-in-t11-tracts-in-rotationally-phased-nucleosome-core-particles-and-dna-minicircles
#9
Kesai Wang, John-Stephen A Taylor
Cyclobutane pyrimidine dimers (CPDs) are DNA photoproducts linked to skin cancer, whose mutagenicity depends in part on their frequency of formation and deamination. Nucleosomes modulate CPD formation, favoring outside facing sites and disfavoring inward facing sites. A similar pattern of CPD formation in protein-free DNA loops suggests that DNA bending causes the modulation in nucleosomes. To systematically study the cause and effect of nucleosome structure on CPD formation and deamination, we have developed a circular permutation synthesis strategy for positioning a target sequence at different superhelix locations (SHLs) across a nucleosome in which the DNA has been rotationally phased with respect to the histone octamer by TG motifs...
May 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28521710/physicochemical-and-structural-studies-on-shaping-of-%C3%AE-hairpin-in-proteins-as-a-first-stage-of-amyloid-formation
#10
Joanna Makowska
The aggregation of proteins or their digested fragments through β-sheet structures has a great significance because it leads to neurodegenerative diseases, which are a problem of the aging societies of the developed countries. Short peptides are typically used as models to study the formation of specific structures. However, while the formation of α-helical structure was investigated thoroughly, until recently, there have been much fewer studies on the formation of β-structure. In this review, recent experimental and theoretical studies of β-hairpin-forming peptides, both model alanine-based systems, and those based on the fragments of real proteins, are summarized with regard to the role of hydrophobic, local, and Coulombic interactions...
May 15, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28521272/impact-of-prematurity-on-exercise-capacity-and-agility-of-children-and-youth-aged-8-to-18
#11
Tatjana Robič Pikel, Gregor Starc, Janko Strel, Marjeta Kovač, Janez Babnik, Petra Golja
BACKGROUND: Preterm (PT) birth and low birth mass (LBW) can impair growth and development of children and may therefore affect their physical performance up to adulthood. AIMS: Our aim was to evaluate long-term consequences of prematurity, especially (an)aerobic exercise capacity and agility up to adulthood, by comparing premature and full-term (FT) individuals. STUDY DESIGN, SUBJECTS: From 474 subjects born in 1987, who were enrolled into a longitudinal study, 396 (178 PT and 218 FT (with 127 of them LBW)) were followed-up into their early adulthood...
May 15, 2017: Early Human Development
https://www.readbyqxmd.com/read/28515839/hypotensive-responses-of-reciprocal-supersets-versus-traditional-resistance-training-in-apparently-healthy-men
#12
Claudio M Bentes, Pablo B Costa, Victor G Corrêa Neto, Roberto Simão, Gabriel A Paz, Marianna F Maia, Tiago Figueiredo, Gabriel R Neto, Jefferson S Novaes, Humberto Miranda
The purpose of this study was to compare the hypotensive responses of reciprocal supersets (SS) versus traditional training (TRAD) methods. Thirteen men with at least five years of recreational experience in resistance training (RT) volunteered for the study. When completing the TRAD protocol, participants performed the following exercises separately in sequence: chest press (CP), low row (LR), leg extension (LE), leg curl (LC), pull down (PD), and shoulder press (SP). The SS method required participants to complete the same exercises as in the TRAD protocol, but exercises were coupled such that muscles sequentially served both as an agonist for lift one and then antagonist for lift two and vice versa...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28513674/molecular-organization-in-the-twist-bend-nematic-phase-by-resonant-x-ray-scattering-at-the-se-k-edge-and-by-saxs-waxs-and-gixrd
#13
W D Stevenson, Z Ahmed, X B Zeng, C Welch, G Ungar, G H Mehl
Using a magnetically aligned liquid crystal mixture containing a novel Se-labelled dimer and the difluoroterphenyl dimer DTC5C7, the twist-bend nematic phase (Ntb) was studied by the resonant scattering of hard X-rays and by conventional small and wide-angle X-ray scattering (SAXS, WAXS). Resonant diffraction spots indicated a helix with a 9-12 nm pitch in the Ntb phase and an unprecedentedly high helix orientation. This enabled deconvolution of global and local order parameters. These findings, combined with the simultaneously recorded resonant and non-resonant SAXS and WAXS data, allowed us to construct a locally layered molecular model of the Ntb phase, where the average twisted conformation of each molecule was idealised as a helical segment, matching the local heliconical director field...
May 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28513180/infrared-spectra-of-neutral-bent-carbon-dioxide
#14
Sergy Yu Grebenshchikov
A combined ab initio and quantum dynamical study characterizes a family of bent neutral carbon dioxide molecules in terms of their vibrational levels, electric dipole moment surfaces, and infrared spectra in the gas phase. The considered isomers include the dioxiranylidene form of CO2 with the equilibrium valence angle of 72(o), belonging to the ground electronic state, and four open structures with the valence angles of 118(o)/119(o) (they belong to the singlet and triplet electronic states 2(1)A' and 1(3)A', respectively) and 127(o)/128(o) (states 1(1)A" and 1(3)A", respectively)...
May 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28512374/description-of-enchodorus-yeatsi-n-sp-dorylaimida-nordiidae-from-southern-iran-and-its-molecular-phylogenetic-study
#15
Majid Pedram
Enchodorus yeatsi n. sp., a new species of the rare genus Enchodorus is described and illustrated based on its morphological and molecular characters. It was recovered from southern Iran. Females of the new species are characterized by having 1,511.3- to 1,792.5-µm long slender body, angular lip region having prominent papillae, 12- to 13-µm long odontostyle, double guiding ring, simple rod-like odontophore, didelphic-amphidelphic reproductive system, and 102- to 160-µm long elongate-conoid tail with rounded tip...
March 2017: Journal of Nematology
https://www.readbyqxmd.com/read/28508504/aiba-aibb-induces-an-intramolecular-decarboxylation-in-isovalerate-biosynthesis-by-myxococcus-xanthus
#16
Tobias Bock, Eva Luxenburger, Judith Hoffmann, Vlad Schütza, Christian Feiler, Rolf Müller, Wulf Blankenfeldt
Isovaleryl coenzyme A (IV-CoA) is an important precursor for iso-fatty acids and lipids. It acts in the development of myxobacteria, which can produce this compound from acetyl-CoA through alternative IV-CoA biosynthesis (aib). A central reaction of aib is catalyzed by AibA/AibB, which acts as a cofactor-free decarboxylase despite belonging to the family of CoA-transferases. We developed an efficient expression system for AibA/AibB that allowed the determination of high-resolution crystal structures in complex with different ligands...
May 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28508250/a-real-world-analysis-of-treatment-patterns-for-cholinesterase-inhibitors-and-memantine-among-newly-diagnosed-alzheimer-s-disease-patients
#17
Nawal Bent-Ennakhil, Florence Coste, Lin Xie, Myrlene Sanon Aigbogun, Yuexi Wang, Furaha Kariburyo, Ann Hartry, Onur Baser, Peter Neumann, Howard Fillit
INTRODUCTION: Alzheimer's disease (AD) is the most common neurodegenerative form of dementia. Pharmacological therapies for symptomatic treatment, such as acetylcholinesterase inhibitors (AChEIs) and memantine, have been available in the USA since 2000. Over the past decade, few studies have analyzed real-world anti-dementia treatment patterns in the USA. This study evaluated monotherapy AChEIs and memantine treatment patterns among newly diagnosed AD patients. METHODS: A retrospective cohort study was conducted using Medicare data and the Minimum Data Set from 2008 to 2012...
May 15, 2017: Neurology and Therapy
https://www.readbyqxmd.com/read/28507684/synthesis-and-reactivity-of-a-ruthenocene-type-complex-bearing-an-aromatic-%C3%AF-ligand-with-the-heaviest-group-14-element
#18
Marisa Nakada, Takuya Kuwabara, Shunsuke Furukawa, Masahiko Hada, Mao Minoura, Masaichi Saito
An anionic ruthenocene derived from a dilithioplumbole complex was prepared. In the complex, the plumbole ligand coordinates a ruthenium atom in an η(5)-fashion, similar to the cyclopentadienyl ligand in ferrocene. The ruthenocene that has the aromatic π-ligand with the heaviest group 14 element reacted with electrophiles to afford the plumbole complexes wherein the plumbole ligands show deviation from planarity, in contrast to the planar plumbole ring in the anionic ruthenocene. The bent angles of the plumbole ligands are dependent on the substituents on the lead atoms...
April 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28504637/-evidence-of-the-effect-of-psychodynamic-psychotherapy
#19
Francisco Alberdi Olano, Bent Rosenbaum
Evidence of the effect of psychodynamic psychotherapy (PDT) has been called into question. Thus, an updated review of the effect of short-term and long-term PDT (STPP and LTPP) for anxiety, depression and personality disorders seems necessary. A systematic search of randomized controlled studies of PDT published from January 2000 to May 2016 was conducted, and we found 57 single studies and 13 meta-analyses fulfilling the criteria for inclusion. The studies show that PDT has therapeutic efficacy and effectiveness matching other forms of psychotherapy...
May 15, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28500858/the-coumarin-dimer-spring-the-struggle-between-charge-transfer-and-steric-interactions
#20
Daniel T Gryko, Andrzej Sobolewski, Olaf Morawski, Łukasz Kielesiński, Łukasz Dobrzycki
The synthesis of weakly coupled, strongly polarized coumarin-dimer has been achieved for the first time. The three-steps strategy comprises of formylation, followed by formation of tertiary amide. The molecule consists of two different coumarin moieties: one is classical donor-acceptor system and the second one possesses weaker amide donor at position 7. We show that polarized coumarin-dimer can form electronically conjugated structure possessing electric dipole larger than that of 7-(dimethylamino)-coumarin-3-carboxylic acid...
May 13, 2017: Chemistry: a European Journal
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